Search

Your search keyword '"Magni R"' showing total 143 results
Start Over Author "Magni R"
143 results on '"Magni R"'

5. Brief Report: Self-Based and Mechanical-Based Future Thinking in Children with Autism Spectrum Disorder

Author

Marini, A., Ferretti, F., Chiera, A., Magni, R., Adornetti, I., Nicchiarelli, S., Vicari, S., and Valeri, G.

Subjects
Self-presentation -- Observations, Child communication -- Observations, Pervasive developmental disorders -- Social aspects, Health
Abstract

This brief report is a partial replication of the study by Jackson and Atance (J Dev Disabil 14:40-45, 2008 (See CR12)) assessing nonverbal Self-based and Mechanical-based future thinking (FT) in children with Autism Spectrum Disorder (ASD). In a first step, these tasks were administered to 30 children with ASD. The two Self-based tasks were then modified as a verbal component could not be completely ruled out. Consequently, 77 children with ASD and 77 children with typical development received the modified Self-based FT tasks and the Mechanical-based FT tasks. We partially replicated the previous findings. Participants with ASD had impaired FT in both kinds of tasks and both groups performed better on tasks assessing Mechanical-based FT than Self-based FT. These results suggest that impairments of FT in ASD are not limited to Self-Projection., Author(s): A. Marini[sup.1] [sup.2] , F. Ferretti[sup.3] , A. Chiera[sup.3] , R. Magni[sup.4] , I. Adornetti[sup.3] , S. Nicchiarelli[sup.3] , S. Vicari[sup.4] , G. Valeri[sup.4] Author Affiliations: (1) Department of [...]

Published
2016
Full Text
View/download PDF

6. Heteroplasmy of wild type mitochondrial DNA variants in mice causes metabolic heart disease with pulmonary hypertension and frailty

Author

Lechuga-Vieco, A.V., Latorre-Pellicer, A., Calvo, E., Torroja, C., Pellico, J., Acín-Pérez, R., García-Gil, M.L., Santos, A., Bagwan, N., Bonzon-Kulichenko, E., Magni, R., Benito, M., Justo-Méndez, R., Simon, A.K., Sánchez-Cabo, F., Vázquez, J., Ruíz-Cabello, J., and Enríquez, J.A.

Abstract

BACKGROUND: In most eukaryotic cells, the mitochondrial DNA (mtDNA) is uniparentally transmitted and present in multiple copies derived from the clonal expansion of maternally inherited mtDNA. All copies are therefore near-identical, or homoplasmic. The presence of more than one mtDNA variant in the same cytoplasm can arise naturally or result from new medical technologies aimed at preventing mitochondrial genetic diseases and improving fertility. The latter is called divergent non-pathological mtDNAs heteroplasmy (DNPH). We hypothesized that DNPH is maladaptive and usually prevented by the cell. METHODS: We engineered and characterized DNPH mice throughout their lifespan using transcriptomic, metabolomic, biochemical, physiological and phenotyping techniques. We focused on in vivo imaging techniques for non-invasive assessment of cardiac and pulmonary energy metabolism. RESULTS: We show that DNPH impairs mitochondrial function, with profound consequences in critical tissues that cannot resolve heteroplasmy, particularly cardiac and skeletal muscle. Progressive metabolic stress in these tissues leads to severe pathology in adulthood, including pulmonary hypertension and heart failure, skeletal muscle wasting, frailty, and premature death. Symptom severity is strongly modulated by the nuclear context. CONCLUSIONS: Medical interventions that may generate DNPH should address potential incompatibilities between donor and recipient mtDNA.

Published
2022

7. Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease with Pulmonary Hypertension and Frailty; 35236094

Author

Lechuga-Vieco, A., Latorre-Pellicer, A., Calvo, E., Torroja, C., Pellico, J., Acín-Pérez, R., García-Gil, M. L., Santos, A., Bagwan, N., Bonzon-Kulichenko, E., Magni, R., Benito, M., Justo-Méndez, R., Simon, A. K., Sánchez-Cabo, F., Vázquez, J., Ruíz-Cabello, J., and Enríquez, J. A.

Abstract

Background: In most eukaryotic cells, the mitochondrial DNA (mtDNA) is transmitted uniparentally and present in multiple copies derived from the clonal expansion of maternally inherited mtDNA. All copies are therefore near-identical, or homoplasmic. The presence of >1 mtDNA variant in the same cytoplasm can arise naturally or result from new medical technologies aimed at preventing mitochondrial genetic diseases and improving fertility. The latter is called divergent nonpathologic mtDNA heteroplasmy (DNPH). We hypothesized that DNPH is maladaptive and usually prevented by the cell. Methods: We engineered and characterized DNPH mice throughout their lifespan using transcriptomic, metabolomic, biochemical, physiologic, and phenotyping techniques. We focused on in vivo imaging techniques for noninvasive assessment of cardiac and pulmonary energy metabolism. Results: We show that DNPH impairs mitochondrial function, with profound consequences in critical tissues that cannot resolve heteroplasmy, particularly cardiac and skeletal muscle. Progressive metabolic stress in these tissues leads to severe pathology in adulthood, including pulmonary hypertension and heart failure, skeletal muscle wasting, frailty, and premature death. Symptom severity is strongly modulated by the nuclear context. Conclusions: Medical interventions that may generate DNPH should address potential incompatibilities between donor and recipient mtDNA. © 2022 Lippincott Williams and Wilkins. All rights reserved.

Published
2022

13. Brief Report: Self-Based and Mechanical-Based Future Thinking in Children with Autism Spectrum Disorder

Author

Marini, Andrea, Ferretti, Ferretto, Chiera, A., Magni, R., Adornetti, I., Nicchiarelli, S., Vicari, Stefano, Valeri, G., Marini A., Ferretti F., Vicari S. (ORCID:0000-0002-5395-2262), Marini, Andrea, Ferretti, Ferretto, Chiera, A., Magni, R., Adornetti, I., Nicchiarelli, S., Vicari, Stefano, Valeri, G., Marini A., Ferretti F., and Vicari S. (ORCID:0000-0002-5395-2262)

Abstract

This brief report is a partial replication of the study by Jackson and Atance (J Dev Disabil 14:40–45, 2008) assessing nonverbal Self-based and Mechanical-based future thinking (FT) in children with Autism Spectrum Disorder (ASD). In a first step, these tasks were administered to 30 children with ASD. The two Self-based tasks were then modified as a verbal component could not be completely ruled out. Consequently, 77 children with ASD and 77 children with typical development received the modified Self-based FT tasks and the Mechanical-based FT tasks. We partially replicated the previous findings. Participants with ASD had impaired FT in both kinds of tasks and both groups performed better on tasks assessing Mechanical-based FT than Self-based FT. These results suggest that impairments of FT in ASD are not limited to Self-Projection.

Published
2016

16. The development of episodic future thinking in middle childhood.

Author

Ferretti, F., Chiera, A., Nicchiarelli, S., Adornetti, I., Magni, R., Vicari, S., Valeri, G., and Marini, A.

Abstract

The ability to imagine future events (episodic future thinking—EFT) emerges in preschoolers and further improves during middle childhood and adolescence. In the present study, we focused on the possible cognitive factors that affect EFT and its development. We assessed the ability to mentally project forward in time of a large cohort of 135 6- to 11-year-old children through a task with minimal narrative demands (the Picture Book Trip task adapted from Atance and Meltzoff in Cogn Dev 20(3):341–361. doi:10.1016/j.cogdev.2005.05.001, 2005) in order to avoid potential linguistic effects on children’s performance. The results showed that this task can be used to assess the development of EFT at least until the age of 8. Furthermore, EFT scores correlated with measures of phonological short-term and verbal working memory. These results support the possibility that cognitive factors such as working memory play a key role in EFT. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

20. TUMOUR BIOLOGY

Author

Geller, T., primary, Prakash, V., additional, Batanian, J., additional, Guzman, M., additional, Duncavage, E., additional, Gershon, T., additional, Crowther, A., additional, Wu, J., additional, Liu, H., additional, Fang, F., additional, Davis, I., additional, Tripolitsioti, D., additional, Ma, M., additional, Kumar, K., additional, Grahlert, J., additional, Egli, K., additional, Fiaschetti, G., additional, Shalaby, T., additional, Grotzer, M., additional, Baumgartner, M., additional, Braoudaki, M., additional, Lambrou, G. I., additional, Giannikou, K., additional, Millionis, V., additional, Papadodima, S. A., additional, Settas, N., additional, Sfakianos, G., additional, Stefanaki, K., additional, Kattamis, A., additional, Spiliopoulou, C. A., additional, Tzortzatou-Stathopoulou, F., additional, Kanavakis, E., additional, Gholamin, S., additional, Mitra, S., additional, Feroze, A., additional, Zhang, M., additional, Esparza, R., additional, Kahn, S., additional, Richard, C., additional, Achrol, A., additional, Volkmer, A., additional, Liu, J., additional, Volkmer, J., additional, Majeti, R., additional, Weissman, I., additional, Cheshier, S., additional, Bhatia, K., additional, Brown, N., additional, Teague, J., additional, Lo, P., additional, Challis, J., additional, Beshay, V., additional, Sullivan, M., additional, Mechinaud, F., additional, Hansford, J., additional, Arifin, M. Z., additional, Dahlan, R. H., additional, Sobana, M., additional, Saputra, P., additional, Tisell, M. T., additional, Danielsson, A., additional, Caren, H., additional, Bhardwaj, R., additional, Chakravadhanula, M., additional, Hampton, C., additional, Ozals, V., additional, Georges, J., additional, Decker, W., additional, Kodibagkar, V., additional, Nguyen, A., additional, Legrain, M., additional, Gaub, M. P., additional, Pencreach, E., additional, Chenard, M. P., additional, Guenot, D., additional, Entz-Werle, N., additional, Kanemura, Y., additional, Ichimura, K., additional, Shofuda, T., additional, Nishikawa, R., additional, Yamasaki, M., additional, Shibui, S., additional, Arai, H., additional, Xia, J., additional, Brian, A., additional, Prins, R., additional, Pennell, C., additional, Moertel, C., additional, Olin, M., additional, Bie, L., additional, Zhang, X., additional, Olsson, M., additional, Kling, T., additional, Nelander, S., additional, Biassoni, V., additional, Bongarzone, I., additional, Verderio, P., additional, Massimino, M., additional, Magni, R., additional, Pizzamiglio, S., additional, Ciniselli, C., additional, Taverna, E., additional, De Bortoli, M., additional, Luchini, A., additional, Liotta, L., additional, Barzano, E., additional, Spreafico, F., additional, Visse, E., additional, Sanden, E., additional, Darabi, A., additional, Siesjo, P., additional, Jackson, S., additional, Cohen, K., additional, Lin, D., additional, Burger, P., additional, Rodriguez, F., additional, Yao, X., additional, Liucheng, R., additional, Qin, L., additional, Na, T., additional, Meilin, W., additional, Zhengdong, Z., additional, Yongjun, F., additional, Pfeifer, S., additional, Nister, M., additional, de Stahl, T. D., additional, Basmaci, E., additional, Orphanidou-Vlachou, E., additional, Brundler, M.-A., additional, Sun, Y., additional, Davies, N., additional, Wilson, M., additional, Pan, X., additional, Arvanitis, T., additional, Grundy, R., additional, Peet, A., additional, Eden, C., additional, Ju, B., additional, Phoenix, T., additional, Nimmervoll, B., additional, Tong, Y., additional, Ellison, D., additional, Lessman, C., additional, Taylor, M., additional, Gilbertson, R., additional, Folgiero, V., additional, del Bufalo, F., additional, Carai, A., additional, Cefalo, M. G., additional, Citti, A., additional, Rutella, S., additional, Locatelli, F., additional, Mastronuzzi, A., additional, Maher, O., additional, Khatua, S., additional, Zaky, W., additional, Lourdusamy, A., additional, Meijer, L., additional, Layfield, R., additional, Jones, D. T. W., additional, Capper, D., additional, Sill, M., additional, Hovestadt, V., additional, Schweizer, L., additional, Lichter, P., additional, Zagzag, D., additional, Karajannis, M. A., additional, Aldape, K. D., additional, Korshunov, A., additional, von Deimling, A., additional, Pfister, S., additional, Chakrabarty, A., additional, Feltbower, R., additional, Sheridon, E., additional, Hassan, H., additional, Shires, M., additional, Picton, S., additional, Hatziagapiou, K., additional, Tsorteki, F., additional, Bethanis, K., additional, Gemou-Engesaeth, V., additional, Chi, S. N., additional, Bandopadhayay, P., additional, Janeway, K., additional, Pinches, N., additional, Malkin, H., additional, Kieran, M. W., additional, Manley, P. E., additional, Green, A., additional, Goumnerova, L., additional, Ramkissoon, S., additional, Harris, M. H., additional, Ligon, K. L., additional, Kahlert, U., additional, Suarez, M., additional, Maciaczyk, J., additional, Bar, E., additional, Eberhart, C., additional, Kenchappa, R., additional, Krishnan, N., additional, Forsyth, P., additional, McKenzie, B., additional, Pisklakova, A., additional, McFadden, G., additional, Pan, W., additional, Rodriguez, L., additional, Glod, J., additional, Levy, J. M., additional, Thompson, J., additional, Griesinger, A., additional, Amani, V., additional, Donson, A., additional, Birks, D., additional, Morgan, M., additional, Handler, M., additional, Foreman, N., additional, Thorburn, A., additional, Lulla, R. R., additional, Laskowski, J., additional, Fangusaro, J., additional, DiPatri, A. J., additional, Alden, T., additional, Tomita, T., additional, Vanin, E. F., additional, Goldman, S., additional, Soares, M. B., additional, Remke, M., additional, Ramaswamy, V., additional, Wang, X., additional, Jorgensen, F., additional, Morrissy, A. S., additional, Marra, M., additional, Packer, R., additional, Bouffet, E., additional, Jabado, N., additional, Cole, B., additional, Rudzinski, E., additional, Anderson, M., additional, Bloom, K., additional, Lee, A., additional, Leary, S., additional, Leprivier, G., additional, Rotblat, B., additional, Agnihotri, S., additional, Kool, M., additional, Derry, B., additional, Taylor, M. D., additional, Sorensen, P. H., additional, Dobson, T., additional, Busschers, E., additional, Taylor, H., additional, Hatcher, R., additional, Lulla, R., additional, Rajaram, V., additional, Das, C., additional, and Gopalakrishnan, V., additional

Published
2014
Full Text
View/download PDF

22. Pigmented Contact-Dermatitis From Deodorant

Author

Pincelli, Carlo, Magni, R., and Motolese, A.

Subjects
COSMETICS AND TOILETRIES, HYPERPIGMENTATION, ALLERGIC CONTACT DERMATITIS, DEODORANTS, FRAGRANCE
Published
1993

23. ICT for home-based service to maintain the upper limb function in ageing

Author

Rogante, M., primary, Bernabeau, M., additional, Giacomozzi, C., additional, Hermens, H., additional, Huijgen, B., additional, Ilsbroukx, S., additional, Magni, R., additional, Opisso, E., additional, Scattareggia, S., additional, Marchese, S.S., additional, Vollenbroek-Hutten, M., additional, Zampolini, M., additional, and Macellari, V., additional

Published
2008
Full Text
View/download PDF

25. Upper limb telerehabilitation with Home Care and Activity Desk (HCAD) system

Author

Zampolini, M., primary, Baratta, S., additional, Schifini, F., additional, Spitali, C., additional, Todeschini, E., additional, Bernabeu, M., additional, Tormos, JM., additional, Opisso, E., additional, Magni, R., additional, Magnino, F., additional, Huijgen, BCH, additional, Vollenbroek-Hutten, MMR, additional, Hermens, HJ, additional, Nieuwenhoven, van J, additional, Ilsbroukx, S, additional, Scattareggia, Marchese S., additional, Macellari, V, additional, and Giacomozzi, C, additional

Published
2007
Full Text
View/download PDF

35. Microphthalmos with colobomatous orbital cyst in trisomy 13

Author

Magni, R., Pierro, L., and Brancato, R.

Abstract

The authors describe a case of trisomy 13 with microphthalmos and colobomatous cyst of the optic nerve and of the chorioretina with orbital extension, in a six-month-old female patient. The colobomatous cyst has been studied by means of computerized axial tomography and ultrasonography in order to follow its evolution. The orbital cyst has not increased in size.

Published
1991
Full Text
View/download PDF

36. VEP pattern after photostress: an index of macular function

Author

Cordella M, Franchi A, Magni R, and Lodigiani L

Subjects
Adult, Carotid Artery Diseases, medicine.medical_specialty, genetic structures, Eye disease, Occlusive disease, Connective tissue, Visual evoked potentials, Audiology, Examination method, Cellular and Molecular Neuroscience, Retinal Diseases, Reference Values, Ophthalmology, Medicine, Humans, Macula Lutea, Aged, Retina, business.industry, Middle Aged, medicine.disease, Connective tissue disease, eye diseases, Sensory Systems, Macular function, medicine.anatomical_structure, Evoked Potentials, Visual, business, Photic Stimulation, Hydroxychloroquine
Abstract

Eighty-seven subjects were examined by means of visual evoked potentials (VEPs) to evaluate the recovery time of the amplitude of the pattern VEP after photostress. Twenty-eight subjects were normal and 59 patients were affected by carotid occlusive disease, vascular retinopathies with and without macular involvement, and connective tissue diseases treated with antimalarial drugs. This examination method emphasizes visual dysfunction in a stage where ophthalmological changes are absent or minimal and therefore may be a useful test for the investigation of macular function.

Published
1987

Catalog

Books, media, physical & digital resources
See catalog results