1. NIR-Triggered Blasting Nanovesicles for Targeted Multimodal Image-Guided Synergistic Cancer Photothermal and Chemotherapy.
- Author
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Xiao Z, You Y, Liu Y, He L, Zhang D, Cheng Q, Wang D, Chen T, Shi C, and Luo L
- Subjects
- A549 Cells, Aniline Compounds chemistry, Aniline Compounds radiation effects, Aniline Compounds toxicity, Animals, Antineoplastic Agents chemistry, Antineoplastic Agents toxicity, Cisplatin chemistry, Cisplatin toxicity, Contrast Media toxicity, Drug Carriers radiation effects, Drug Carriers toxicity, Drug Liberation, Drug Therapy, Fluorocarbons toxicity, Humans, Infrared Rays, Magnetic Iron Oxide Nanoparticles chemistry, Magnetic Iron Oxide Nanoparticles radiation effects, Magnetic Iron Oxide Nanoparticles toxicity, Mice, Nude, Photothermal Therapy, Silicates chemistry, Silicates toxicity, Xenograft Model Antitumor Assays, Mice, Antineoplastic Agents therapeutic use, Cisplatin therapeutic use, Contrast Media chemistry, Drug Carriers chemistry, Fluorocarbons chemistry, Neoplasms drug therapy
- Abstract
Escorting therapeutics for malignancies by nano-encapsulation to ameliorate treatment effects and mitigate side effects has been pursued in precision medicine. However, the majority of drug delivery systems suffer from uncontrollable drug release kinetics and thus lead to unsatisfactory triggered-release efficiency along with severe side effects. Herein, we developed a unique nanovesicle delivery system that shows near-infrared (NIR) light-triggered drug release behavior and minimal premature drug release. By co-encapsulation of superparamagnetic iron oxide (SPIO) nanoparticles, the ultrasound contrast agent perfluorohexane (PFH), and cisplatin in a silicate-polyaniline vesicle, we achieved the controllable release of cisplatin in a thermal-responsive manner. Specifically, vaporization of PFH triggered by the heat generated from NIR irradiation imparts high inner vesicle pressure on the nanovesicles, leading to pressure-induced nanovesicle collapse and subsequent cisplatin release. Moreover, the multimodal imaging capability can track tumor engagement of the nanovesicles and assess their therapeutic effects. Due to its precise inherent NIR-triggered drug release, our system shows excellent tumor eradication efficacy and biocompatibility in vivo , empowering it with great prospects for future clinical translation.
- Published
- 2021
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