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Complex-I-deficiency represents the most frequent pathogenetic cause of human mitochondriopathies. Therapeutic options for these neurodevelopmental life-threating disorders do not exist, partly due to the scarcity of appropriate model systems to study them. Caenorhabditis elegans is a genetically tractable model organism widely used to investigate neuronal pathologies. Here, we generate C. elegans models for mitochondriopathies and show that depletion of complex I subunits recapitulates biochemical, cellular and neurodevelopmental aspects of the human diseases. We exploit two models, nuo-5/NDUFS1- and lpd-5/NDUFS4-depleted animals, for a suppressor screening that identifies lutein for its ability to rescue animals' neurodevelopmental deficits. We uncover overexpression of synaptic neuroligin as an evolutionarily conserved consequence of mitochondrial dysfunction, which we find to mediate an early cholinergic defect in C. elegans. We show lutein exerts its beneficial effects by restoring neuroligin expression independently from its antioxidant activity, thus pointing to a possible novel pathogenetic target for the human disease.

The Dark Matter Cinema Tarot was developed by Silvia Maglioni & Graeme Thomson during their residency common infra/ctions at Les Laboratoires d’Aubervilliers and constitutes what the artists refer to as a “vernacular technology”. After being invited to CA2M, Madrid, where several readings were made as part of JORNADAS DE ESTUDIO DE LA IMAGEN 2016, it has now become a fully nomadic practice, assuming a different form each time a Nocturnal Committee takes place. Whenever a Nocturnal Committee is called, members of the assembled group may pose questions to the cards, and through the collective reading that ensues, explore ways in which the images can open up new channels of inter- and infra-subjective perception, connecting different realms of personal, aesthetic and political experience and enquiry by reaching towards the dark matter that haunts the cinematographic image. At the same time, they can tease out alternative narratives and divinatory or therapeutic possibilities that may lie in the constellation of figures and forms resulting from each fall of the cards. In conceiving the DMC Tarot, the artists have replaced the Major and Minor Arcana with a selection of still images drawn from the history of cinema. No longer tied to the symbolism of the classical tarot, suspended between contingency and fatality, the DMC cards refract the questions posed to them through a process of speculative description and collective fabulation and story-telling, with each reading forming a singular montage of gestures, situations and relations. Readings are frequently interwoven with screenings of film sequences and the playing or performance of durational sound pieces that expand upon territories of infra-perception unveiled by the cards., Dark Matter Cinema Tarot fue desarrollado por Silvia Maglioni y Graeme Thomson durante su residencia common infra/ctions en Los laboratorios de Aubervilliers y constituye lo que los artistas denominan “una tecnología vernácula”. Tras ser invitados al CA2M de Madrid, donde se llevaron a cabo una serie de lecturas dentro de las Jornadas de Estudio de la Imagen 2016, esta obra es ahora una práctica nómada que adopta formas diversas cada vez que el Comité Nocturno se reúne. Cuando se convoca un Comité nocturno, los integrantes del grupo pueden hacer preguntas a las cartas y, a través de su lectura colectiva, explorar maneras en las que las imágenes pueden abrir nuevos canales para la percepción inter e infra subjetiva, conectando la pesquisa con espacios diversos de experiencia personal, estética y política, acercándose a la materia oscura que acecha la imagen cinematográfica. Al mismo tiempo, los miembros del grupo pueden tantear las narrativas alternativas y posibilidades adivinatorias o terapéuticas contenidas en la constelación de formas y figuras resultantes de cada tirada de cartas. Al concebir el Cine tarot de la materia oscura los artistas sustituyeron los Arcanos Mayor y Menor con una selección de imágenes de la historia del cine. Desprendidas del simbolismo del tarot clásico, suspendidas entre la contingencia y la fatalidad, las cartas del Cine tarot de la materia oscura rebotan las preguntas que reciben a través de un proceso de descripción especulativa, fabulación colectiva y narración de historias, en el que cada lectura forma un singular montaje de gestos, situaciones y relaciones. Las lecturas suelen estar entretejidas con proyecciones de secuencias de cine, además de la reproducción o actuación de piezas de sonido duracionales que se expanden hacia los territorios de infrapercepción descubiertos por las cartas.

The present text establishes a narrative of the filmmaking process by the authors ofFacts of life. A film developed with 18 hours of video from Gilles Deleuze´s courses at the university of Vincennes (1975-76). A working material taped by Marielle Burkhalter as part of her Master Project ‘film thought in its becoming’., El presente texto constituye una narrativa sobre la película de los autores, Facts of life, que partió de 18 horas de vídeo de los cursos de Gilles Deleuze en la universidad de Vincennes, en 1975-76, un material en bruto grabado por Marielle Burkhalter como parte de su proyecto de Máster de “filmar el pensamiento en su devenir”.

Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4′- dimethoxychalcone (DMC) as a natural compound with anti-ageing properties. External DMC administration extends the lifespan of yeast, worms and flies, decelerates senescence of human cell cultures, and protects mice from prolonged myocardial ischaemia. Concomitantly, DMC induces autophagy, which is essential for its cytoprotective effects from yeast to mice. This pro-autophagic response induces a conserved systemic change in metabolism, operates independently of TORC1 signalling and depends on specific GATA transcription factors. Notably, we identify DMC in the plant Angelica keiskei koidzumi, to which longevity- and health-promoting effects are ascribed in Asian traditional medicine. In summary, we have identified and mechanistically characterised the conserved longevity-promoting effects of a natural anti-ageing drug.