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1. Development of ion-beam sputtered silicon nitride thin films for low-noise mirror coatings of gravitational-wave detectors

Author

Amato, A., Bazzan, M., Cagnoli, G., Canepa, M., Coulon, M., Degallaix, J., Demos, N., Evans, M., Fabrizi, F., Favaro, G., Forest, D., Gras, S., Hofman, D., Lemaitre, A., Maggioni, G., Magnozzi, M., Martinez, V., Mereni, L., Michel, C., Milotti, V., Montani, M., Paolone, A., Pereira, A., Piergiovanni, F., Pierro, V., Pinard, L., Pinto, I. M., Placidi, E., Samandari, S., Sassolas, B., Shcheblanov, N., Teillon, J., Vickridge, I., and Granata, M.

Subjects
Physics - Instrumentation and Detectors
Abstract

Brownian thermal noise of thin-film coatings is a fundamental limit for high-precision experiments based on optical resonators such as gravitational-wave interferometers. Here we present the results of a research activity aiming to develop lower-noise ion-beam sputtered silicon nitride thin films compliant with the very stringent requirements on optical loss of gravitational-wave interferometers. In order to test the hypothesis of a correlation between the synthesis conditions of the films and their elemental composition and optical and mechanical properties, we varied the voltage, current intensity and composition of the sputtering ion beam, and we performed a broad campaign of characterizations. While the refractive index was found to monotonically depend on the beam voltage and linearly vary with the N/Si ratio, the optical absorption appeared to be strongly sensitive to other factors, as yet unidentified. However, by systematically varying the deposition parameters, an optimal working point was found. Thus we show that the loss angle and extinction coefficient of our thin films can be as low as $(1.0 \pm 0.1) \times 10^{-4}$ rad at $\sim$2.8 kHz and $(6.4 \pm 0.2) \times 10^{-6}$ at 1064 nm, respectively, after thermal treatment at 900 $^{\circ}$C. Such loss angle value is the lowest ever measured on this class of thin films. We then used our silicon nitride thin films to design and produce a multi-material mirror coating showing a thermal noise amplitude of $(10.3 \pm 0.2) \times 10^{-18}$ m Hz$^{-1/2}$ at 100 Hz, which is 25\% lower than in current mirror coatings of the Advanced LIGO and Advanced Virgo interferometers, and an optical absorption as low as $(1.9 \pm 0.2)$ parts per million at 1064 nm.

Published
2024

2. Characterization of ion-beam-sputtered AlF$_3$ thin films for gravitational-wave interferometers

Author

Bischi, M., Amato, A., Bazzan, M., Cagnoli, G., Canepa, M., Favaro, G., Forest, D., Gobbi, P., Granata, M., Guidi, G. M., Maggioni, G., Martelli, F., Menotta, M., Montani, M., Piergiovanni, F., and Valentini, L.

Subjects
Physics - Instrumentation and Detectors
Abstract

Thermal noise in amorphous coatings is a limitation for a wide range of precision experiments such as gravitational-wave detectors (GWDs). Mirrors for GWDs are composed of multiple thin layers of dielectric materials deposited on a substrate: the stack is made of layers with a high refractive index interleaved with layers of a low refractive index. The goal is to obtain high reflectivity and low thermal noise. In this paper we report on the optical and mechanical properties of ion-beam-sputtered aluminium fluoride (AlF$_3$) thin films which have one of the lowest refractive index among the known coating materials and we discuss their application in current and future GWDs., Comment: arXiv admin note: text overlap with arXiv:2111.01646

Published
2022

3. Measurement and simulation of mechanical and optical properties of sputtered amorphous SiC coatings

Author

Favaro, G., Amato, A., Arciprete, F., Bazzan, M., Cesarini, E., De Matteis, F., Dao, T. H., Granata, M., Honrado-Benítez, C., Gutiérrez-Luna, N., Larruquert, J. I., Lorenzin, G., Lumaca, D., Maggioni, G., Magnozzi, M., Placidi, E., Prosposito, P., and Puosi, F.

Subjects
Physics - Instrumentation and Detectors
Abstract

In this work We report on the extensive characterization of amorphous silicon carbide (a-SiC) coatings prepared by physical deposition methods. We compare the results obtained on two different sputtering systems (a standard RF magnetron sputtering and a ion-beam assisted sputtering) to seize the impact of two different setups on the repeatably of the results. After a thorough characterization of structural, morphological, and compositional characteristics of the prepared samples, we focus on a detailed study of the optical and mechanical losses in those materials. Mechanical losses are further investigated from a microscopic point of view by comparing our experimental results with molecular dynamic simulations of the amorphous SiC structure: first we define a protocol to generate a numerical model of the amorphous film, capturing the main features of the real system; then we simulate its dynamical behaviour upon deformation in order to obtain its mechanical response. Our results are discussed within the perspective application of a-SiC as an optical material for high-precision optical experiments and in particular in gravitational wave interferometry., Comment: 30 pages, 11 figures

Published
2022

4. Optical and mechanical properties of ion-beam-sputtered MgF$_2$ thin films for gravitational-wave interferometers

Author

Granata, M., Amato, A., Bischi, M., Bazzan, M., Cagnoli, G., Canepa, M., Chicoine, M., Di Michele, A., Favaro, G., Forest, D., Guidi, G. M., Maggioni, G., Martelli, F., Menotta, M., Montani, M., Piergiovanni, F., and Schiettekatte, F.

Subjects
Physics - Instrumentation and Detectors
Abstract

Brownian thermal noise associated with highly reflective coatings is a fundamental limit for several precision experiments, including gravitational-wave detectors. Research is currently ongoing to find coatings with low thermal noise that also fulfill strict optical requirements such as low absorption and scatter. We report on the optical and mechanical properties of ion-beam-sputtered magnesium fluoride thin films, and we discuss the application of such coatings in current and future gravitational-wave detectors.

Published
2021
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5. Investigation on radiation generated by Sub-GeV electrons in ultrashort Si and Ge bent crystals

Author

Bandiera, L., Sytov, A., De Salvador, D., Mazzolari, A., Bagli, E., Camattari, R., Carturan, S., Durighello, C., Germogli, G., Guidi, V., Klag, P., Lauth, W., Maggioni, G., Mascagna, V., Prest, M., Romagnoni, M., Soldani, M., Tikhomirov, V. V., and Vallazza, E.

Subjects
Physics - Accelerator Physics
Abstract

We report on the measurements of the spectra of gamma radiation generated by 855 MeV electrons in bent silicon and germanium crystals at MAMI (MAinzer MIkrotron). The crystals were 15 {\mu}m thick along the beam direction to ensure high deflection efficiency. Their (111) crystalline planes were bent by means of a piezo-actuated mechanical holder, which allowed to remotely change the crystal curvature. In such a way it was possible to investigate the radiation emitted under planar channeling and volume reflection as a function of the curvature of the crystalline planes. We show that using volume reflection, one can produce intense gamma radiation with comparable intensity but higher angular acceptance than for channeling. We studied the trade-off between radiation intensity and angular acceptance at different values of the crystal curvature. The measurements of radiation spectra have been carried out for the first time in bent Germanium crystals. In particular, the intensity of radiation in the Ge crystal is higher than in the Si one due to the higher atomic number, which is important for the development of the X-ray and gamma radiation sources based on higher-Z deformed crystals, such as crystalline undulator., Comment: 9 pages, 6 figures

Published
2020
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6. Innovative remotely-controlled bending device for thin silicon and germanium crystals

Author

De Salvador, D., Carturan, S., Mazzolari, A., Bagli, E., Bandiera, L., Durighello, C., Germogli, G., Guidi, V., Klag, P., Lauth, W., Maggioni, G., Romagnoni, M., and Sytov, A.

Subjects
Physics - Instrumentation and Detectors
Abstract

Steering of negatively charged particle beams below 1 GeV has demonstrated to be possible with thin bent silicon and germanium crystals. A newly designed mechanical holder was used for bending crystals, since it allows a remotely-controlled adjustment of crystal bending and compensation of unwanted torsion. Bent crystals were installed and tested at the MAMI Mainz MIcrotron to achieve steering of 0.855-GeV electrons at different bending radii. We report the description and characterization of the innovative bending device developed at INFN Laboratori Nazionali di Legnaro (LNL).

Published
2020
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7. Broad angular anisotropy of multiple scattering in a Si crystal

Author

Mazzolari, A., Sytov, A., Bandiera, L., Germogli, G., Romagnoni, M., Bagli, E., Guidi, V., Tikhomirov, V. V., De Salvador, D., Carturan, S., Durigello, C., Maggioni, G., Campostrini, M., Berra, A., Mascagna, V., Prest, M., Vallazza, E., Lauth, W., Klag, P., and Tamisari, M.

Subjects
Physics - Accelerator Physics, Condensed Matter - Materials Science, Physics - Instrumentation and Detectors
Abstract

We observed reduction of multiple Coulomb scattering of 855 MeV electrons within a Si crystalline plate w.r.t. an amorphous plate with the same mass thickness. The reduction owed to complete or partial suppression of the coherent part of multiple scattering in a crystal vs crystal orientation with the beam. Experimental data were collected at Mainz Mikrotron and critically compared to theoretical predictions and Monte Carlo simulations. Our results highlighted maximal 7 % reduction of the r.m.s. scattering angle at certain beam alignment with the [100] crystal axes. However, partial reduction was recorded over a wide range of alignment of the electron beam with the crystal up to 15 deg. This evidence may be relevant to refine the modelling of multiple scattering in crystals for currently used software, which is interesting for detectors in nuclear, medical, high energy physics., Comment: 8 pages, 4 figures, submitted to the European Physical Journal C

Published
2019
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8. Nuclear physics midterm plan at Legnaro National Laboratories (LNL)

Author

Ballan, M., Bottoni, S., Caamaño, M., Caciolli, A., Campostrini, M., Cicerchia, M., Crespi, F. C. L., Cristallo, S., Dell’Aquila, D., Depalo, R., Fioretto, E., Galtarossa, F., Gasques, L. R., Gottardo, A., Gramegna, F., Gulminelli, F., Kurtukian-Nieto, T., La Cognata, M., Lenzi, S. M., Marchi, T., Mazurek, K., Mengoni, D., Mou, L., Nania, R., Pupillo, G., Valiente-Dobón, J. J., Zanon, I., Acosta, L., Alvarez, M. A. G., Andrighetto, A., Arazi, A., Arzenton, A., Assié, M., Bagatin, M., Barbaro, F., Barbieri, C., Barlini, S., Basiricò, L., Battistoni, G., Beaumel, D., Bentley, M. A., Benzoni, G., Bertoldo, S., Bertulani, C., Bonasera, A., Camaiani, A., Canton, L., Capirossi, V., Carante, M. P., Carraro, C., Carturan, S. M., Casini, G., Cavanna, F., Centofante, L., Chávez, E. R., Chbihi, A., Ciemała, M., Cisternino, S., Colombi, A., Colucci, M., Compagnucci, A., Corradetti, S., Corradi, L., D’Agata, G., de Angelis, G., De Dominicis, L., De Salvador, D., DeFilippo, E., Del Fabbro, M., Di Nitto, A., Ditalia Tchernij, S., Donzella, A., Duguet, T., Esposito, J., Favela, F., Fernández-García, J. P., Flavigny, F., Fontana, A., Fornal, B., Forneris, J., Fraboni, B., Frankland, J., Gamba, E., Geraci, E., Gerardin, S., Giuliani, S. A., Gnoffo, B., Groppi, F., Gruyer, D., Haddad, F., Isaak, J., Kmiecik, M., Koning, A., Lamia, L., Le Neindre, N., Leoni, S., Lépine-Szily, A., Lilli, G., Lombardo, I., Loriggiola, M., Loriggiola, L., Lunardon, M., Maggioni, G., Maj, A., Manenti, S., Manzolaro, M., Marcucci, L. E., Marín-Lámbarri, D. J., Mariotti, E., Martin Hernandez, G., Massimi, C., Mastinu, P., Mazzocco, M., Mazzolari, A., Mijatović, T., Mishenina, T., Mizuyama, K., Monetti, A., Montagnoli, G., Morselli, L., Moschini, L., Musacchio Gonzalez, E., Nannini, A., Niu, Y. F., Ota, S., Paccagnella, A., Palmerini, S., Pellegri, L., Perego, A., Piantelli, S., Piatti, D., Picollo, F., Pignatari, M., Pinna, F., Pirrone, S., Pizzone, R. G., Polettini, M., Politi, G., Popescu, L., Prete, G., Quaranta, A., Raabe, R., Ramos, J. P., Raniero, W., Rapisarda, G. G., Recchia, F., Rigato, V., Roca Maza, X., Rocchini, M., Rodriguez, T., Roncolato, C., Rudolph, D., Russotto, P., Sánchez-Benítez, Á. M., Savran, D., Scarpa, D., Scheck, M., Sekizawa, K., Sergi, M. L., Sgarbossa, F., Silvestrin, L., Singh Khwairakpam, O., Skowronski, J., Somà, V., Spartà, R., Spieker, M., Stefanini, A. M., Steiger, H., Stevanato, L., Stock, M. R., Vardaci, E., Verney, D., Vescovi, D., Vittone, E., Werner, V., Wheldon, C., Wieland, O., Wimmer, K., Wyss, J., Zago, L., and Zenoni, A.

Published
2023
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10. Siloxane-based 6LiF composites for flexible thermal neutron scintillation sensors with high efficiency: effects of 6LiF crystals size and dispersion homogeneity

Author

Carturan, S. M., Vesco, M., Bonesso, I., Quaranta, A., Maggioni, G., Stevanato, L., Zanazzi, E., Marchi, T., Fabris, D., Cinausero, M., and Gramegna, F.

Subjects
Physics - Instrumentation and Detectors, Condensed Matter - Materials Science
Abstract

The production of flexible and robust thermal neutron detectors with improved properties as compared to the commercial ZnS:Ag based phosphors is here pursued, exploiting a siloxane binder, whose intrinsic properties as related to the chemical features of the functional groups and to the optical properties are investigated and tailored in correlation with the final performances of the detectors. Two different siloxanes either with pendant phenyl groups or with aliphatic groups have been used, the former being intrinsically fluorescent and with higher polarizability than the latter. Moreover, 6LiF crystals have been synthesized by co-precipitation method and the solvent/co-solvent ratio has been changed in order to tune the crystal size. Then, the size effect on the detector efficiency to thermal neutrons has been investigated as related to the energy loss of thermal neutron reaction products inside the crystal and the dispersion homogeneity of the crystals into the composite. To complete the characterization of the produced flexible detectors, the response to {\gamma}-rays has been measured and compared to a commercial detector. The careful choice of both the base resin and the 6LiF crystals size allows to produce flexible detector for thermal neutrons with performances comparable to the commercial standard and with higher mechanical robustness and stability., Comment: submitted to European Physical Journal A, EPJA-104631, currently under review

Published
2018

11. Steering of Sub-GeV electrons by ultrashort Si and Ge bent crystals

Author

Sytov, A. I., Bandiera, L., De Salvador, D., Mazzolari, A., Bagli, E., Berra, A., Carturan, S., Durighello, C., Germogli, G., Guidi, V., Klag, P., Lauth, W., Maggioni, G., Prest, M., Romagnoni, M., Tikhomirov, V. V., and Vallazza, E.

Subjects
Physics - Accelerator Physics
Abstract

We report the observation of the steering of 855 MeV electrons by bent silicon and germanium crystals at the MAinzer MIkrotron. 15 $\mu $m long crystals, bent along (111) planes, were exploited to investigate orientational coherent effects. By using a piezo-actuated mechanical holder, which allowed to remotely change the crystal curvature, it was possible to study the steering capability of planar channeling and volume reflection vs. the curvature radius and the atomic number, Z. For silicon, the channeling efficiency exceeds 35 %, a record for negatively charged particles. This was possible due to the realization of a crystal with a thickness of the order of the dechanneling length. On the other hand, for germanium the efficiency is slightly below 10 % due to the stronger contribution of multiple scattering for a higher-Z material. Nevertheless this is the first evidence of negative beam steering by planar channeling in a Ge crystal. Having determined for the first time the dechanneling length, one may design a Ge crystal based on such knowledge providing nearly the same channeling efficiency of silicon. The presented results are relevant for crystal-based beam manipulation as well as for the generation of e.m. radiation in bent and periodically bent crystals., Comment: 12 pages, 10 figures, submitted to Eur. Phys. J. C

Published
2017
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13. When the practice does not meet the theory: results from an Italian survey on the clinical and pathway management of inpatients with decompressive craniectomy or cranioplasty admitted to rehabilitation

Author

La Porta, F, Formisano, R, Iaccarino, C, Lavezzi, S, Pompucci, A, Estraneo, A, De Tanti, A, Achilli, M, Acler, M, Antenucci, R, Avesani, R, Bagnato, S, Battistini, A, Bellaviti, G, Bertoni, M, Brianti, R, Carboncini, M, Castelli, E, Castronovo, G, Chiapparino, C, Colombo, V, Cosentino, E, De Cicco, D, Fassio, C, Felicita, P, Gambarelli, C, Gambrain, M, Gentile, S, Intiso, D, Lombardi, F, Lucca, L, Maggioni, G, Marino, S, Montis, A, Nardone, A, Perin, C, Premoselli, S, Romoli, A, Salvi, G, Scarponi, F, Tedesco, L, Vezzadini, G, La Porta F., Formisano R., Iaccarino C., Lavezzi S., Pompucci A., Estraneo A., De Tanti A., Achilli M. P., Acler M., Antenucci R., Avesani R., Bagnato S., Battistini A., Bellaviti G., Bertoni M., Brianti R., Carboncini M. C., Castelli E., Castronovo G., Chiapparino C., Colombo V., Cosentino E., De Cicco D., Fassio C., Felicita P., Gambarelli C., Gambrain M., Gentile S., Intiso D., Lombardi F., Lucca L. F., Maggioni G., Marino S., Montis A., Nardone A., Perin C., Premoselli S., Romoli A. M., Salvi G. P., Scarponi F., Tedesco L., Vezzadini G., La Porta, F, Formisano, R, Iaccarino, C, Lavezzi, S, Pompucci, A, Estraneo, A, De Tanti, A, Achilli, M, Acler, M, Antenucci, R, Avesani, R, Bagnato, S, Battistini, A, Bellaviti, G, Bertoni, M, Brianti, R, Carboncini, M, Castelli, E, Castronovo, G, Chiapparino, C, Colombo, V, Cosentino, E, De Cicco, D, Fassio, C, Felicita, P, Gambarelli, C, Gambrain, M, Gentile, S, Intiso, D, Lombardi, F, Lucca, L, Maggioni, G, Marino, S, Montis, A, Nardone, A, Perin, C, Premoselli, S, Romoli, A, Salvi, G, Scarponi, F, Tedesco, L, Vezzadini, G, La Porta F., Formisano R., Iaccarino C., Lavezzi S., Pompucci A., Estraneo A., De Tanti A., Achilli M. P., Acler M., Antenucci R., Avesani R., Bagnato S., Battistini A., Bellaviti G., Bertoni M., Brianti R., Carboncini M. C., Castelli E., Castronovo G., Chiapparino C., Colombo V., Cosentino E., De Cicco D., Fassio C., Felicita P., Gambarelli C., Gambrain M., Gentile S., Intiso D., Lombardi F., Lucca L. F., Maggioni G., Marino S., Montis A., Nardone A., Perin C., Premoselli S., Romoli A. M., Salvi G. P., Scarponi F., Tedesco L., and Vezzadini G.

Abstract

BACKGROUND: Cranioplasty (CP) is supposed to improve the functional outcome of severe acquired brain injury (sABI) patients with decompressive craniectomy (DC). However, ongoing controversies exist regarding its indications, optimum materials, timing, complications, and relationships with hydrocephalus (HC). For these reasons, an International Consensus Conference (ICC) on CP in traumatic brain injury (TBI) was held in June 2018 to issue some recommendations. AIM: The aims of this study were: to investigate cross-sectionally before the ICC the prevalence of DC/CP in sABI inpatients admitted to neu- rorehabilitation units in Italy; to assess the perception of Italian clinicians working in the sABI neurorehabilitation settings on the management of inpatients with DC/CP during their rehabilitation stay. DESIGN: Cross-sectional. SETTING AND POPULATION: Physiatrists or neurologists working in 38 Italian rehabilitation centers involved in the care of sABI, giving a pooled sample of 599 inpatients. METHODS: Survey questionnaire consisting of 21 closed-ended questions with multiple-choice answers. Sixteen questions regarded the respondents' opinions and experiences regarding the clinical and management aspects of patients. Survey data were collected via e-mail between April and May 2018. RESULTS: About 1/3 of the 599 inpatients had either a DC (18.9%) or a CP (13.5%). TBI and cerebral hemorrhage were strongly associated with DC/CP, although the association was much stronger for TBI. Significant discrepancies were uncovered between some of the recommendations of the ICC and the corresponding perceptions of the respondents, especially regarding the clinical management of patients (i.e., CP timing). Clear guidelines were perceived as the most crucial factor in improving clinical pathways. CONCLUSIONS: Early collaboration between the neurosurgical and the neurorehabilitation teams is crucial to optimize all clinical and organizational factors, which could expedite CP and minimi

Published
2023

14. Synthetic Data Generation by Artificial Intelligence to Accelerate Research and Precision Medicine in Hematology

Author

D'Amico, S, Dall'Olio, D, Sala, C, Dall'Olio, L, Sauta, E, Zampini, M, Asti, G, Lanino, L, Maggioni, G, Campagna, A, Ubezio, M, Russo, A, Bicchieri, M, Riva, E, Tentori, C, Travaglino, E, Morandini, P, Savevski, V, Santoro, A, Prada-Luengo, I, Krogh, A, Santini, V, Kordasti, S, Platzbecker, U, Diez-Campelo, M, Fenaux, P, Haferlach, T, Castellani, G, Della Porta, M, D'Amico S., Dall'Olio D., Sala C., Dall'Olio L., Sauta E., Zampini M., Asti G., Lanino L., Maggioni G., Campagna A., Ubezio M., Russo A., Bicchieri M. E., Riva E., Tentori C. A., Travaglino E., Morandini P., Savevski V., Santoro A., Prada-Luengo I., Krogh A., Santini V., Kordasti S., Platzbecker U., Diez-Campelo M., Fenaux P., Haferlach T., Castellani G., Della Porta M. G., D'Amico, S, Dall'Olio, D, Sala, C, Dall'Olio, L, Sauta, E, Zampini, M, Asti, G, Lanino, L, Maggioni, G, Campagna, A, Ubezio, M, Russo, A, Bicchieri, M, Riva, E, Tentori, C, Travaglino, E, Morandini, P, Savevski, V, Santoro, A, Prada-Luengo, I, Krogh, A, Santini, V, Kordasti, S, Platzbecker, U, Diez-Campelo, M, Fenaux, P, Haferlach, T, Castellani, G, Della Porta, M, D'Amico S., Dall'Olio D., Sala C., Dall'Olio L., Sauta E., Zampini M., Asti G., Lanino L., Maggioni G., Campagna A., Ubezio M., Russo A., Bicchieri M. E., Riva E., Tentori C. A., Travaglino E., Morandini P., Savevski V., Santoro A., Prada-Luengo I., Krogh A., Santini V., Kordasti S., Platzbecker U., Diez-Campelo M., Fenaux P., Haferlach T., Castellani G., and Della Porta M. G.

Abstract

PURPOSE: Synthetic data are artificial data generated without including any real patient information by an algorithm trained to learn the characteristics of a real source data set and became widely used to accelerate research in life sciences. We aimed to (1) apply generative artificial intelligence to build synthetic data in different hematologic neoplasms; (2) develop a synthetic validation framework to assess data fidelity and privacy preservability; and (3) test the capability of synthetic data to accelerate clinical/translational research in hematology. METHODS: A conditional generative adversarial network architecture was implemented to generate synthetic data. Use cases were myelodysplastic syndromes (MDS) and AML: 7,133 patients were included. A fully explainable validation framework was created to assess fidelity and privacy preservability of synthetic data. RESULTS: We generated MDS/AML synthetic cohorts (including information on clinical features, genomics, treatment, and outcomes) with high fidelity and privacy performances. This technology allowed resolution of lack/incomplete information and data augmentation. We then assessed the potential value of synthetic data on accelerating research in hematology. Starting from 944 patients with MDS available since 2014, we generated a 300% augmented synthetic cohort and anticipated the development of molecular classification and molecular scoring system obtained many years later from 2,043 to 2,957 real patients, respectively. Moreover, starting from 187 MDS treated with luspatercept into a clinical trial, we generated a synthetic cohort that recapitulated all the clinical end points of the study. Finally, we developed a website to enable clinicians generating high-quality synthetic data from an existing biobank of real patients. CONCLUSION: Synthetic data mimic real clinical-genomic features and outcomes, and anonymize patient information. The implementation of this technology allows to increase the scientific

Published
2023

15. Novel Scintillating Materials Based on Phenyl-Polysiloxane for Neutron Detection and Monitoring

Author

Degerlier, M., Carturan, S., Gramegna, F., Marchi, T., Palma, M. Dalla, Cinausero, M., Maggioni, G., Quaranta, A., Collazuol, G., and Bermudez, J.

Subjects
Physics - Instrumentation and Detectors
Abstract

Neutron detectors are extensively used at many nuclear research facilities across Europe. Their application range covers many topics in basic and applied nuclear research: in nuclear structure and reaction dynamics (reaction reconstruction and decay studies); in nuclear astrophysics (neutron emission probabilities); in nuclear technology (nuclear data measurements and in-core/off-core monitors); in nuclear medicine (radiation monitors, dosimeters); in materials science (neutron imaging techniques); in homeland security applications (fissile materials investigation and cargo inspection). Liquid scintillators, widely used at present, have however some drawbacks given by toxicity, flammability, volatility and sensitivity to oxygen that limit their duration and quality. Even plastic scintillators are not satisfactory because they have low radiation hardness and low thermal stability. Moreover organic solvents may affect their optical properties due to crazing. In order to overcome these problems, phenyl-polysiloxane based scintillators have been recently developed at Legnaro National Laboratory. This new solution showed very good chemical and thermal stability and high radiation hardness. The results on the different samples performance will be presented, paying special attention to a characterization comparison between synthesized phenyl containing polysiloxane resins where a Pt catalyst has been used and a scintillating material obtained by condensation reaction, where tin based compounds are used as catalysts. Different structural arrangements as a result of different substituents on the main chain have been investigated by High Resolution X-Ray Diffraction, while the effect of improved optical transmittance on the scintillation yield has been elucidated by a combination of excitation/fluorescence measurements and scintillation yield under exposure to alpha and {\gamma}-rays., Comment: InterM 2013 - International Multidisciplinary Microscopy Congress

Published
2013
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23. Real-World Validation of Molecular International Prognostic Scoring System for Myelodysplastic Syndromes

Author

Sauta, E, Robin, M, Bersanelli, M, Travaglino, E, Meggendorfer, M, Zhao, L, Caballero Berrocal, J, Sala, C, Maggioni, G, Bernardi, M, Di Grazia, C, Vago, L, Rivoli, G, Borin, L, D'Amico, S, Tentori, C, Ubezio, M, Campagna, A, Russo, A, Mannina, D, Lanino, L, Chiusolo, P, Giaccone, L, Voso, M, Riva, M, Oliva, E, Zampini, M, Riva, E, Nibourel, O, Bicchieri, M, Bolli, N, Rambaldi, A, Passamonti, F, Savevski, V, Santoro, A, Germing, U, Kordasti, S, Santini, V, Diez-Campelo, M, Sanz, G, Sole, F, Kern, W, Platzbecker, U, Ades, L, Fenaux, P, Haferlach, T, Castellani, G, Della Porta, M, Sauta, Elisabetta, Robin, Marie, Bersanelli, Matteo, Travaglino, Erica, Meggendorfer, Manja, Zhao, Lin-Pierre, Caballero Berrocal, Juan Carlos, Sala, Claudia, Maggioni, Giulia, Bernardi, Massimo, Di Grazia, Carmen, Vago, Luca, Rivoli, Giulia, Borin, Lorenza, D'Amico, Saverio, Tentori, Cristina Astrid, Ubezio, Marta, Campagna, Alessia, Russo, Antonio, Mannina, Daniele, Lanino, Luca, Chiusolo, Patrizia, Giaccone, Luisa, Voso, Maria Teresa, Riva, Marta, Oliva, Esther Natalie, Zampini, Matteo, Riva, Elena, Nibourel, Olivier, Bicchieri, Marilena, Bolli, Niccolo', Rambaldi, Alessandro, Passamonti, Francesco, Savevski, Victor, Santoro, Armando, Germing, Ulrich, Kordasti, Shahram, Santini, Valeria, Diez-Campelo, Maria, Sanz, Guillermo, Sole, Francesc, Kern, Wolfgang, Platzbecker, Uwe, Ades, Lionel, Fenaux, Pierre, Haferlach, Torsten, Castellani, Gastone, Della Porta, Matteo Giovanni, Sauta, E, Robin, M, Bersanelli, M, Travaglino, E, Meggendorfer, M, Zhao, L, Caballero Berrocal, J, Sala, C, Maggioni, G, Bernardi, M, Di Grazia, C, Vago, L, Rivoli, G, Borin, L, D'Amico, S, Tentori, C, Ubezio, M, Campagna, A, Russo, A, Mannina, D, Lanino, L, Chiusolo, P, Giaccone, L, Voso, M, Riva, M, Oliva, E, Zampini, M, Riva, E, Nibourel, O, Bicchieri, M, Bolli, N, Rambaldi, A, Passamonti, F, Savevski, V, Santoro, A, Germing, U, Kordasti, S, Santini, V, Diez-Campelo, M, Sanz, G, Sole, F, Kern, W, Platzbecker, U, Ades, L, Fenaux, P, Haferlach, T, Castellani, G, Della Porta, M, Sauta, Elisabetta, Robin, Marie, Bersanelli, Matteo, Travaglino, Erica, Meggendorfer, Manja, Zhao, Lin-Pierre, Caballero Berrocal, Juan Carlos, Sala, Claudia, Maggioni, Giulia, Bernardi, Massimo, Di Grazia, Carmen, Vago, Luca, Rivoli, Giulia, Borin, Lorenza, D'Amico, Saverio, Tentori, Cristina Astrid, Ubezio, Marta, Campagna, Alessia, Russo, Antonio, Mannina, Daniele, Lanino, Luca, Chiusolo, Patrizia, Giaccone, Luisa, Voso, Maria Teresa, Riva, Marta, Oliva, Esther Natalie, Zampini, Matteo, Riva, Elena, Nibourel, Olivier, Bicchieri, Marilena, Bolli, Niccolo', Rambaldi, Alessandro, Passamonti, Francesco, Savevski, Victor, Santoro, Armando, Germing, Ulrich, Kordasti, Shahram, Santini, Valeria, Diez-Campelo, Maria, Sanz, Guillermo, Sole, Francesc, Kern, Wolfgang, Platzbecker, Uwe, Ades, Lionel, Fenaux, Pierre, Haferlach, Torsten, Castellani, Gastone, and Della Porta, Matteo Giovanni

Abstract

Purpose: Myelodysplastic syndromes (MDS) are heterogeneous myeloid neoplasms in which a risk-adapted treatment strategy is needed. Recently, a new clinical-molecular prognostic model, the Molecular International Prognostic Scoring System (IPSS-M) was proposed to improve the prediction of clinical outcome of the currently available tool (Revised International Prognostic Scoring System [IPSS-R]). We aimed to provide an extensive validation of IPSS-M. Methods: A total of 2,876 patients with primary MDS from the GenoMed4All consortium were retrospectively analyzed. Results: IPSS-M improved prognostic discrimination across all clinical end points with respect to IPSS-R (concordance was 0.81 v 0.74 for overall survival and 0.89 v 0.76 for leukemia-free survival, respectively). This was true even in those patients without detectable gene mutations. Compared with the IPSS-R based stratification, the IPSS-M risk group changed in 46% of patients (23.6% and 22.4% of subjects were upstaged and downstaged, respectively).In patients treated with hematopoietic stem cell transplantation (HSCT), IPSS-M significantly improved the prediction of the risk of disease relapse and the probability of post-transplantation survival versus IPSS-R (concordance was 0.76 v 0.60 for overall survival and 0.89 v 0.70 for probability of relapse, respectively). In high-risk patients treated with hypomethylating agents (HMA), IPSS-M failed to stratify individual probability of response; response duration and probability of survival were inversely related to IPSS-M risk.Finally, we tested the accuracy in predicting IPSS-M when molecular information was missed and we defined a minimum set of 15 relevant genes associated with high performance of the score. Conclusion: IPSS-M improves MDS prognostication and might result in a more effective selection of candidates to HSCT. Additional factors other than gene mutations can be involved in determining HMA sensitivity. The definition of a minimum set of relevan

Published
2023

24. A sex-informed approach to improve the personalised decision making process in myelodysplastic syndromes: a multicentre, observational cohort study

Author

Maggioni, G, Bersanelli, M, Travaglino, E, Alfonso Piérola, A, Kasprzak, A, Sangerman Montserrat, A, Sauta, E, Sala, C, Matteuzzi, T, Meggendorfer, M, Gnocchi, M, Zhao, L, Astrid Tentori, C, Nachtkamp, K, Dall'Olio, D, Mosca, E, Ubezio, M, Campagna, A, Russo, A, Rivoli, G, Bernardi, M, Borin, L, Teresa Voso, M, Riva, M, Oliva, E, Zampini, M, Riva, E, Saba, E, D'Amico, S, Lanino, L, Tinterri, B, Re, F, Bicchieri, M, Giordano, L, Angelotti, G, Morandini, P, Sophie Kubasch, A, Passamonti, F, Rambaldi, A, Savevski, V, Santoro, A, A van de Loosdrecht, A, Brogi, A, Santini, V, Kordasti, S, Sanz, G, Sole, F, Gattermann, N, Kern, W, Platzbecker, U, Ades, L, Fenaux, P, Haferlach, T, Castellani, G, Germing, U, Diez-Campelo, M, G Della Porta, M, Giulia Maggioni, Matteo Bersanelli, Erica Travaglino, Ana Alfonso Piérola, Annika Kasprzak, Arnan Sangerman Montserrat, Elisabetta Sauta, Claudia Sala, Tommaso Matteuzzi, Manja Meggendorfer, Matteo Gnocchi, Lin-Pierre Zhao, Cristina Astrid Tentori, Kathrin Nachtkamp, Daniele Dall'Olio, Ettore Mosca, Marta Ubezio, Alessia Campagna, Antonio Russo, Giulia Rivoli, Massimo Bernardi, Lorenza Borin, Maria Teresa Voso, Marta Riva, Esther Oliva, Matteo Zampini, Elena Riva, Elena Saba, Saverio D'Amico, Luca Lanino, Benedetta Tinterri, Francesca Re, Marilena Bicchieri, Laura Giordano, Giovanni Angelotti, Pierandrea Morandini, Anne Sophie Kubasch, Francesco Passamonti, Alessandro Rambaldi, Victor Savevski, Armando Santoro, Arjan A van de Loosdrecht, Alice Brogi, Valeria Santini, Shahram Kordasti, Guillermo Sanz, Francesc Sole, Norbert Gattermann, Wolfgang Kern, Uwe Platzbecker, Lionel Ades, Pierre Fenaux, Torsten Haferlach, Gastone Castellani, Ulrich Germing, Maria Diez-Campelo, Matteo G Della Porta, Maggioni, G, Bersanelli, M, Travaglino, E, Alfonso Piérola, A, Kasprzak, A, Sangerman Montserrat, A, Sauta, E, Sala, C, Matteuzzi, T, Meggendorfer, M, Gnocchi, M, Zhao, L, Astrid Tentori, C, Nachtkamp, K, Dall'Olio, D, Mosca, E, Ubezio, M, Campagna, A, Russo, A, Rivoli, G, Bernardi, M, Borin, L, Teresa Voso, M, Riva, M, Oliva, E, Zampini, M, Riva, E, Saba, E, D'Amico, S, Lanino, L, Tinterri, B, Re, F, Bicchieri, M, Giordano, L, Angelotti, G, Morandini, P, Sophie Kubasch, A, Passamonti, F, Rambaldi, A, Savevski, V, Santoro, A, A van de Loosdrecht, A, Brogi, A, Santini, V, Kordasti, S, Sanz, G, Sole, F, Gattermann, N, Kern, W, Platzbecker, U, Ades, L, Fenaux, P, Haferlach, T, Castellani, G, Germing, U, Diez-Campelo, M, G Della Porta, M, Giulia Maggioni, Matteo Bersanelli, Erica Travaglino, Ana Alfonso Piérola, Annika Kasprzak, Arnan Sangerman Montserrat, Elisabetta Sauta, Claudia Sala, Tommaso Matteuzzi, Manja Meggendorfer, Matteo Gnocchi, Lin-Pierre Zhao, Cristina Astrid Tentori, Kathrin Nachtkamp, Daniele Dall'Olio, Ettore Mosca, Marta Ubezio, Alessia Campagna, Antonio Russo, Giulia Rivoli, Massimo Bernardi, Lorenza Borin, Maria Teresa Voso, Marta Riva, Esther Oliva, Matteo Zampini, Elena Riva, Elena Saba, Saverio D'Amico, Luca Lanino, Benedetta Tinterri, Francesca Re, Marilena Bicchieri, Laura Giordano, Giovanni Angelotti, Pierandrea Morandini, Anne Sophie Kubasch, Francesco Passamonti, Alessandro Rambaldi, Victor Savevski, Armando Santoro, Arjan A van de Loosdrecht, Alice Brogi, Valeria Santini, Shahram Kordasti, Guillermo Sanz, Francesc Sole, Norbert Gattermann, Wolfgang Kern, Uwe Platzbecker, Lionel Ades, Pierre Fenaux, Torsten Haferlach, Gastone Castellani, Ulrich Germing, Maria Diez-Campelo, and Matteo G Della Porta

Abstract

BACKGROUND: Sex is a major source of diversity among patients and a sex-informed approach is becoming a new paradigm in precision medicine. We aimed to describe sex diversity in myelodysplastic syndromes in terms of disease genotype, phenotype, and clinical outcome. Moreover, we sought to incorporate sex information into the clinical decision-making process as a fundamental component of patient individuality. METHODS: In this multicentre, observational cohort study, we retrospectively analysed 13 284 patients aged 18 years or older with a diagnosis of myelodysplastic syndrome according to 2016 WHO criteria included in the EuroMDS network (n=2025), International Working Group for Prognosis in MDS (IWG-PM; n=2387), the Spanish Group of Myelodysplastic Syndromes registry (GESMD; n=7687), or the Düsseldorf MDS registry (n=1185). Recruitment periods for these cohorts were between 1990 and 2016. The correlation between sex and genomic features was analysed in the EuroMDS cohort and validated in the IWG-PM cohort. The effect of sex on clinical outcome, with overall survival as the main endpoint, was analysed in the EuroMDS population and validated in the other three cohorts. Finally, novel prognostic models incorporating sex and genomic information were built and validated, and compared to the widely used revised International Prognostic Scoring System (IPSS-R). This study is registered with ClinicalTrials.gov, NCT04889729. FINDINGS: The study included 7792 (58·7%) men and 5492 (41·3%) women. 10 906 (82·1%) patients were White, and race was not reported for 2378 (17·9%) patients. Sex biases were observed at the single-gene level with mutations in seven genes enriched in men (ASXL1, SRSF2, and ZRSR2 p<0·0001 in both cohorts; DDX41 not available in the EuroMDS cohort vs p=0·0062 in the IWG-PM cohort; IDH2 p<0·0001 in EuroMDS vs p=0·042 in IWG-PM; TET2 p=0·031 vs p=0·035; U2AF1 p=0·033 vs p<0·0001) and mutations in two genes were enriched in women (DNMT3A p<0·000

Published
2023

25. Real-World Validation of Molecular International Prognostic Scoring System for Myelodysplastic Syndromes

Author

Sauta, E., Robin, M., Bersanelli, M., Travaglino, E., Meggendorfer, M., Zhao, L. -P., Caballero Berrocal, J. C., Sala, C., Maggioni, G., Bernardi, M., Di Grazia, C., Vago, L., Rivoli, G., Borin, L., D'Amico, S., Tentori, C. A., Ubezio, M., Campagna, A., Russo, A., Mannina, D., Lanino, L., Chiusolo, Patrizia, Giaccone, L., Voso, Maria Teresa, Riva, M., Oliva, E. N., Zampini, M., Riva, E., Nibourel, O., Bicchieri, M., Bolli, N., Rambaldi, A., Passamonti, F., Savevski, V., Santoro, A., Germing, U., Kordasti, S., Santini, V., Diez-Campelo, M., Sanz, G., Sole, F., Kern, W., Platzbecker, U., Ades, L., Fenaux, P., Haferlach, T., Castellani, G., Della Porta, M. G., Chiusolo P. (ORCID:0000-0002-1355-1587), Voso M. T., Sauta, E., Robin, M., Bersanelli, M., Travaglino, E., Meggendorfer, M., Zhao, L. -P., Caballero Berrocal, J. C., Sala, C., Maggioni, G., Bernardi, M., Di Grazia, C., Vago, L., Rivoli, G., Borin, L., D'Amico, S., Tentori, C. A., Ubezio, M., Campagna, A., Russo, A., Mannina, D., Lanino, L., Chiusolo, Patrizia, Giaccone, L., Voso, Maria Teresa, Riva, M., Oliva, E. N., Zampini, M., Riva, E., Nibourel, O., Bicchieri, M., Bolli, N., Rambaldi, A., Passamonti, F., Savevski, V., Santoro, A., Germing, U., Kordasti, S., Santini, V., Diez-Campelo, M., Sanz, G., Sole, F., Kern, W., Platzbecker, U., Ades, L., Fenaux, P., Haferlach, T., Castellani, G., Della Porta, M. G., Chiusolo P. (ORCID:0000-0002-1355-1587), and Voso M. T.

Abstract

PURPOSEMyelodysplastic syndromes (MDS) are heterogeneous myeloid neoplasms in which a risk-adapted treatment strategy is needed. Recently, a new clinical-molecular prognostic model, the Molecular International Prognostic Scoring System (IPSS-M) was proposed to improve the prediction of clinical outcome of the currently available tool (Revised International Prognostic Scoring System [IPSS-R]). We aimed to provide an extensive validation of IPSS-M.METHODSA total of 2,876 patients with primary MDS from the GenoMed4All consortium were retrospectively analyzed.RESULTSIPSS-M improved prognostic discrimination across all clinical end points with respect to IPSS-R (concordance was 0.81 v 0.74 for overall survival and 0.89 v 0.76 for leukemia-free survival, respectively). This was true even in those patients without detectable gene mutations. Compared with the IPSS-R based stratification, the IPSS-M risk group changed in 46% of patients (23.6% and 22.4% of subjects were upstaged and downstaged, respectively).In patients treated with hematopoietic stem cell transplantation (HSCT), IPSS-M significantly improved the prediction of the risk of disease relapse and the probability of post-transplantation survival versus IPSS-R (concordance was 0.76 v 0.60 for overall survival and 0.89 v 0.70 for probability of relapse, respectively). In high-risk patients treated with hypomethylating agents (HMA), IPSS-M failed to stratify individual probability of response; response duration and probability of survival were inversely related to IPSS-M risk.Finally, we tested the accuracy in predicting IPSS-M when molecular information was missed and we defined a minimum set of 15 relevant genes associated with high performance of the score.CONCLUSIONIPSS-M improves MDS prognostication and might result in a more effective selection of candidates to HSCT. Additional factors other than gene mutations can be involved in determining HMA sensitivity. The definition of a minimum set of relevant genes may

Published
2023

27. Novel flexible and conformable composite neutron scintillator based on fully enriched lithium tetraborate

Author

Pino, F., Delgado, J. C., Carturan, S. M., Mantovani, G., Polo, M., Fabris, D., Maggioni, G., Quaranta, A., and Moretto, S.

Subjects
Multidisciplinary
Abstract

Thermal neutron detection is a key subject for nuclear physics research and also in a wide variety of applications from homeland security to nuclear medicine. In this work, it is proposed a novel flexible and conformable composite thermal neutron scintillator based on a fully enriched Lithium Tetraborate preparation ($$^{6}$$ 6 Li$$_2^{10}$$ 2 10 B$$_4$$ 4 O$$_7$$ 7 ) combined with a phosphorescent inorganic scintillator powder (ZnS:Ag), and is then distributed into a polydimethylsiloxane matrix. The proposed scintillator shows a good neutron detection efficiency (max. $$\sim$$ ∼ 57% with respect to the commercial EJ-420), an average light output of $$\sim$$ ∼ 9000 ph/neutron-capture, a remarkable insensitivity to $$\gamma$$ γ -rays (Gamma Rejection Ratio $$^{-11}$$ - 11 ), and an extraordinary flexibility, so as to reach extremely small curvature radii, down to 1.5 mm, with no signs of cracking or tearing. Its characteristics make it suitable to be employed in scenarios where non-standard geometries are needed, for example, to optimize the detector performance and/or maximize the detection efficiency. Finally, the response of a hybrid detector made of a plastic scintillator, wrapped with the proposed scintillator, coupled to a silicon photomultiplier array is described, and the excellent discrimination between $$\gamma$$ γ -rays, fast and thermal neutrons resulting from data processing is demonstrated.

Published
2023

28. Luminescent Cavitands as Novel Optically Active Materials

Author

Tonezzer, M., Menin, E., Carturan, S., Maggioni, G., Quaranta, A., Pinalli, R., Dalcanale, E., Baldini, Francesco, editor, D’Amico, Arnaldo, editor, Di Natale, Corrado, editor, Siciliano, Pietro, editor, Seeber, Renato, editor, De Stefano, Luca, editor, Bizzarri, Ranieri, editor, and Andò, Bruno, editor

Published
2014
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33. Are all people with diabetes and cardiovascular risk factors or microvascular complications at very high risk? Findings from the Risk and Prevention Study

Author

Marzona, Irene, Avanzini, Fausto, Lucisano, Giuseppe, Tettamanti, Mauro, Baviera, Marta, Nicolucci, Antonio, Roncaglioni, Maria Carla, Tombesi, M., Tognoni, G., Massa, E., Marrocco, W., Micalella, M., Caimi, V., Longoni, P., Avanzini, F., Franzosi, M. G., Roncaglioni, M. C., Marzona, I., Baviera, M., Monesi, L., Pangrazzi, I., Barlera, S., Milani, V., Nicolis, E., Casola, C., Clerici, F., Palumbo, A., Sgaroni, G., Marchioli, R., Silletta, M. G., Pioggiarella, R., Scarano, M., Marfisi, R. M., Flamminio, A., Macino, L., Ferri, B., Pera, C., Polidoro, A., Abbatino, D., Acquati, M., Addorisio, G., Adinolfi, D., Adreani, L., Agistri, M. R., Agneta, A., Agnolio, M. L., Agostini, N., Agostino, G., Airò, A., Alaimo, N., Albano, M., Albano, N., Alecci, G., Alemanno, S., Alexanian, A., Alfarano, M., Alfè, L., Alonzo, N., Alvino, S., Ancora, A., Andiloro, S., Andreatta, E., Angeli, S., Angiari, F., Angilletti, V., Annicchiarico, C., Anzivino, M., Aprea, R., Aprile, A., Aprile, E., Aprile, I., Aprile, L., Armellani, V., Arnetoli, M., Aronica, A., Autiero, V., Bacca, G., Baccalaro, A. M., Bacci, M., Baglio, G., Bagnani, M., Baiano, A., Baldari, A., Ballarini, L., Banchi, G., Bandera, R., Bandini, F., Baratella, M., Barbieri, A., Barbieri Vita, A., Bardi, M., Barlocchi, M., Baron, P., Bartoli, M., Basile, A., Basile, F., Basile, S., Battaggia, A., Battaglia, A., Baù, A., Beconcini, G., Beggio, R., Belfiore, P. A., Belicchi, M., Bellamoli, S., Bellini, C., Bellomo, M., Benetollo, C., Benetti, R., Beretta, E., Bertalero, P., Bertaso, F. G., Bertolani, U., Bettelli, G., Biagiotti, G., Bianchi, S., Bianco, G., Biccari, F., Bigioli, F., Bindi, M., Bisanti, G., Bitetti, E. M., Blasetti, M. P., Blesi, F., Boato, V., Boga, S., Boidi, E., Boldrin, G., Bollati, A., Bolzan, L., Bolzonella, S., Bonardi, P., Bonato, G. B., Bonci, M., Bonfitto, G., Bonincontro, E., Boninsegna, F., Bonissone, D., Bono, L., Bonollo, E., Borghi, M., Borioli, N., Borsatto, M., Bosco, T., Bosisio Pioltelli, M., Botarelli, C., Botassis, S., Bottini, F., Bottos, C., Bova, G., Bova, V., Bozzani, A., Bozzetto, R. M., Braga, V. T., Braglia, M., Bramati, E., Brazzoli, C., Breglia, G., Brescia, A., Briganti, D., Brigato, G., Brocchi, A., Brosio, F. A., Bruni, E., Buscaglia, E., Bussini, M. D., Bussotti, A., Buzzaccarini, F., Buzzatti, A., Caccamo, G., Cacciavillani, C., Caggiano, G., Caimi, V., Calciano, F. P., Calderisi, M., Calienno, S., Caltagirone, P., Calzolari, I., Cammisa, M., Campanaro, M., Campanella, G. B., Campese, F., Canali, G., Candiani, D. E. L., Canepa, R., Canini, D., Canino, A., Cantoro, E. A., Capilupi, V., Capotosto, P., Cappelli, B., Capraro, G., Carafa, F. A., Carano, Q., Carcaterra, V., Carriero, D., Carrozzo, G., Cartanese, M., Casalena, M., Casarola, M., Caso, C., Casotto, M., Castaldi, F., Castegnaro, R., Castellani, G., Castri, S., Catalano, E., Catinello, N., Caturano, G., Cavallaro, R., Cavallo, A. M., Cavallo, G., Cavion, M. T., Cavirani, G., Cazzaniga, F., Cazzetta, D., Cecconi, V., Cefalo, A., Celebrano, M., Celora, A., Centonze, P., Cerati, D., Cesaretti, D., Checchia, G., Checchin, A., Cherubini, M., Chianese, L., Chiappa, A., Chiappa, M. V., Chiariello, G., Chiavini, G., Chicco, M., Chiumeo, F., Ciacciarelli, A., Ciaci, D., Ciancaglini, R., Cicale, C., Cicale, S., Cipolla, A., Ciruolo, A., Citeri, A. L., Citterio, G., Clerici, M., Coazzoli, E., Collecchia, G., Colletta, F., Colombo, I., Colorio, P., Coluccia, S., Comerio, M., Comoretto, P., Compagni, M., Conte, O., Contri, S., Contrisciani, A., Coppetti, T., Corasaniti, F., Corradi, M. T., Corsano, A., Corsini, A., Corti, N., Costantini, G., Costantino, A., Cotroneo, S., Cozzi, D., Cravello, M. G., Cristiano, E., Cucchi, R., Cusmai, L., D’Errico, G. B., D’Agostino, P., Dal Bianco, L., Dal Mutto, U., Dal Pozzo, G., Dallapiccola, P., Dallatorre, G., Dalle Molle, G., Dalloni, E., D’Aloiso, A., D’Amicis, G., Danese, R., Danieli, D., Danisi, G., D’Anna, M. A., Danti, G., D’Ascanio, S., Davidde, G., De Angeli, D., De Bastiani, R., De Battisti, A., De Bellis, A., De Berardinis, G., De Carlo, F., De Giorgi, D., De Gobbi, R., De Lorenzis, E., De Luca, P., De Martini, G., De Marzi, M., De Matteis, D., De Padova, S., De Polo, P., De Sabato, N., De Stefano, T., De Vita, M. T., De Vito, U., De Zolt, V., Debernardi, F., Del Carlo, A., Del Re, G., Del Zotti, F., D’Elia, R., Della Giovanna, P., Dell’Acqua, L., Dell’Orco, R. L., Demaria, G., Di Benedetto, M. G., Di Chiara, G., Di Corcia, V., Di Domizio, O., Di Donato, P., Di Donato, S., Di Fermo, G., Di Franco, M., Di Giovannantonio, G., Di Lascio, G., Di Lecce, G., Di Lorenzo, N., Di Maro, T., Di Mattia, Q., Di Michele, E., Di Modica, R. S., Di Murro, D., Di Noi, M. C., Di Paoli, V., Di Santi, M., Di Sanzo, A., Di Turi, C., Diazzi, A., Dileo, I., D’Ingianna, A. P., Dolci, A., Donà, G., Donato, C., Donato, P., Donini, A., Donna, M. E., Donvito, T. V., Esposito, L., Esposito, N., Evangelista, M., Faita, G., Falco, M., Falcone, D. A., Falorni, F., Fanciullacci, A., Fanton, L., Fasolo, L., Fassina, R., Fassone, A., Fatarella, P., Fedele, F., Fera, I., Fera, L., Ferioli, S., Ferlini, M. G., Ferlino, R., Ferrante, G., Ferrara, F. N., Ferrarese, M. F., Ferrari, G., Ferrari, O., Ferreri, A., Ferroni, M., Fezzi, G., Figaroli, C., Fina, M. G., Fioretta, A., Fiorucci, C., Firrincieli, R., Fischetti, M., Fischietti, G., Fiume, D. C., Flecchia, G., Forastiere, G., Fossati, B., Franceschi, P. L., Franchi, L., Franzoso, F., Frapporti, G., Frasca, G., Frisotti, A., Fumagalli, G., Fusco, D., Gabriele, P., Gabrieli, A., Gagliano, D., Galimberti, G., Galli, A., Gallicchio, N., Gallio, F., Gallipoli, T., Gallo, P., Galopin, T., Gambarelli, L., Garbin, A., Garozzo, G. M., Gasparri, R., Gastaldo, M., Gatti, E., Gazzaniga, P., Gennachi, N., Gentile, R. V., Germani, P., Gesualdi, F., Gherardi, E., Ghezzi, C., Ghidini, M. G., Ghionda, F., Giacci, L., Gialdini, D., Giampaolo, C., Giancane, R., Giannanti, A., Giannese, S., Giannini, L., Giaretta, M., Giaretta, R., Giavardi, L., Giordano, P., Giordano, E., Giordano, B., Gioria, G. M., Giugliano, R., Grassi, E. A., Greco, A., Greco, L., Grilletti, N., Grimaldi, N., Grisetti, G., Groppelli, G., Gualtieri, L., Guarducci, M., Guastella, G., Guerra, M., Guerrini, F., Guglielmini, A., Guido, A., Gulotta, P., Iacono, E., Iadarola, G., Ianiro, G., Iarussi, V., Ieluzzi, M. L., Ierardi, C., Ingaldi, F., Interlandi, S., Iocca, M., Iorno, A., Ioverno, E., Iurato, R., La Pace, L., La Piscopia, C., La Selva, R., Lafratta, M., Lamparelli, M., Lanaro, G., Lancerotto, R., Larcher, M., Lassandro, M., Lattuada, G., Laurino, P., Lefons, C., Legrottaglie, F., Lemma, A., Leone, D., Leone, F., Leso, A., Leuzzi, G., Levato, G., Libardi, L., Libralesso, N., Licini, P. I., Licursi, G., Lidonnici, F., Lillo, C., Liveri, L., Livio, A., Loiero, R. A., Loison, M., Lombardo, G., Lombardo, T., Lomunno, V., Lomuscio, S., Lonedo, A., Longo, E., Longoni, P., Lora, L., Lotterio, A., Lucatello, L., Luongo, A., Lupoli, M., Macchia, C., Macri, G., Mafessanti, M., Maggialetti, V., Maggioni, A., Magnani, M., Maiellaro, G., Mancuso, A., Maniglio, A. R., Mannari, G. L., Manni, A., Manocchio, B., Mao, M., Maranò, A., Maraone, E., Marascio, D., Marcheselli, P., Marchetto, B., Marchetto, S., Marchi, A., Marchi, G. L., Mariano, C., Marinacci, S., Marinelli, S., Marini, G., Marra, V. C., Marrali, F., Marseglia, C., Martello, G., Martino, C., Martino, G., Martino, M., Marulli, C. F., Maruzzi, G., Marzotti, A., Mascheroni, G., Mascolo, P., Masoch, G., Masone, R., Massa, E., Massa, L., Massafra, M., Massi, M., Massignani, D. M., Matarese, A. M., Matini, G., Mauro, R., Mazzi, M., Mazzillo, A., Mazzocato, E., Mazzoleni, N. S., Mazzone, A., Melacci, A., Mele, E., Meliota, P., Menaspà, S., Meneghello, F., Merola, G., Merone, L., Metrucci, A., Mezzina, V., Micchi, A., Michielon, A., Migliore, N., Minero, G., Minotta, F., Mirandola, C., Mistrorigo, S., Modafferi, L., Moitre, R., Mola, E., Monachese, C., Mongiardini, C., Montagna, F., Montani, M., Montemurno, I., Montolli, R., Montorsi, S., Montresor, M., Monzani, M. G., Morabito, F., Mori, G., Moro, A., Mosca, M. F., Motti, F., Muddolon, L., Mugnai, M., Muscas, F., Naimoli, F., Nanci, G., Nargi, E., Nasorri, R., Nastrini, G., Negossi, M., Negrini, A., Negroni, A., Neola, V., Niccolini, F., Niro, C. M., Nosengo, C., Novella, G., Nuti, C., Obici, F., Olita, C., Oliverio, S. S., Olivieri, I., Oriente, S., Orlando, G., Paci, C., Pagano, G., Pagliara, C., Paita, G., Paladini, G., Paladino, G., Palano, T., Palatella, A., Palermo, P., Palmisano, M., Pando, P., Panessa, P., Panigo, F., Panozzo, G., Panvini, F., Panzieri, F., Panzino, A., Panzitta, F., Paoli, N., Papagna, R., Papaleo, M. G., Papalia, G., Parisi, R., Parotti, N., Parravicini, D., Passarella, P., Pastore, G. A., Patafio, M., Pavone, P., Pedroli, W., Pedroni, M., Pelligra, G., Pellizzari, M., Penati, A., Perlot, M., Perrone, A., Perrone, G., Peruzzi, P., Peselli, C., Petracchini, L., Petrera, L., Petrone, S., Peverelli, C., Pianorsi, F., Piazza, G. P., Piazzolla, G., Picci, A., Pienabarca, G., Pietronigro, T. P., Pignocchino, P., Pilone, R., Pinto, D., Pirovano, E., Pirrotta, D., Pisante, V., Pitotto, P., Pittari, L., Piva, A., Pizzoglio, A., Plantera, O. R., Plebani, W., Plessi, S., Podrecca, D., Poerio, V., Poggiani, F., Pogliani, W., Poli, L., Poloni, F. G., Porcelli, R., Porto, S., Pranzo, L., Prevedello, C., Profeta, C., Profico, D., Punzi, A., Quaglia, G. M., Racano, M., Raccone, A., Radice, F., Raho, C. A., Raimondi, R., Rainò, M., Ramponi, R., Ramunni, A., Ramunni, A. L., Ravasio, F., Ravera, M., Re Sartò, G., Rebustello, G., Regazzoli, S., Restelli, C., Rezzonico, M., Ricchiuto, F., Rigo, S., Rigon, G., Rigon, R., Rinaldi, O. V., Rinaldi, M., Risplendente, P. G., Rispoli, M., Riundi, R., Riva, M. G., Rizzi, A. L., Rizzi, D., Rizzo, L. D., Rocchi, L., Rondinone, B., Rosa, B., Rosati, F., Roselli, F., Rossetti, A., Rossetti, C., Rossi, R., Rossi, P. R., Rossi, A., Rossi, C. L., Rossitto, A., Ruffini, R., Ruffo, A., Ruggio, S., Ruo, M., Russo, B., Russo, L., Russo, R., Russo, S., Russo, U., Russo, V., Ruta, G., Sacchi, F., Sacco Botto, F., Saia, A., Salladini, G., Salmoiraghi, S., Saluzzo, F., Salvatore, C., Salvatori, E., Salvio, G., Sandri, P., Sandrini, T., Sangermano, V., Santoni, N., Saracino, A. D., Saracino, A., Sarasin, P., Sardo Infirri, C., Sarrì, B., Sartori, G., Sartori, N., Sauro, C., Scaglioni, M., Scalfi, C., Scamardella, A. M., Scandale, G., Scandone, L., Scannavini, G., Scarati, R., Scardi, A., Scarpa, F. M., Scazzi, P., Schifone, A., Schiroso, G., Scigliano, G., Scilla, A., Sciortino, M., Scolaro, G., Scollo, E., Scorretti, G., Sellitti, R., Selmo, A., Selvaggio, G., Sempio, A., Seren, F., Serio, L., Serra, C., Serra, L., Siciliano, D., Sideri, A., Sighele, M., Signore, R., Siliberto, F., Silvestro, M., Simioni, G., Simmini, G., Simonato, L., Sinchetto, F., Sizzano, E., Smajato, G., Smaldone, M., Sola, G., Sordillo, L., Sovran, C. S., Spagnul, P., Spanò, F., Sproviero, S., Squintani, A., Stella, L., Stilo, V., Stocchiero, B., Stornello, M. C., Stracka, G., Strada, S., Stranieri, G., Stucci, N., Stufano, N., Suppa, A., Susca, V. G., Sutti, M., Taddei, M., Tagliabue, E., Tagliente, G., Talato, F., Talerico, P., Talia, R., Taranto, R., Tartaglia, M., Tauro, N., Tedesco, A., Tieri, P., Tirelli, M., Tocci, L., Todesco, P., Tognolo, M., Tomba, A., Tonello, P., Tonon, R., Toscano, L., Tosi, A., Tosi, G., Toso, S., Travaglio, P., Tremul, L., Tresso, C., Triacchini, P., Triggiano, L., Trigilio, A., Trimeloni, J., Tripicchio, G., Tritto, G. S., Trono, F., Trotta, E., Trotta, G., Tubertini, A., Turri, C., Turri, L., Tuttolani, M. P., Urago, M., Ursini, G., Valcanover, F., Valente, L., Valenti, M., Valentini, F., Vallone, G., Valz, P., Valzano, L., Vanin, V., Vatteroni, M., Vegetti, L., Vendrame, D., Veramonti, I., Veronelli, G., Vesco, A., Vicariotto, G., Vignale, G., Villa, P. L., Vinciguerra, R., Visco, A., Visentin, G., Visonà, E., Vitali, E., Vitali, S., Vitti, F., Volpone, D. A., Zambon, N., Zammarrelli, A., Zanaboni, A., Zane, D., Zanetti, B., Zanibellato, R., Zappetti, M., Zappone, P., Zerilli, G., Zirino, V., Zoccali, R., Zuin, F., Altomonte, M., Anelli, N., Angiò, F., Annale, P., Antonacci, S., Anzilotta, R., Bano, F., Basadonna, O., Beduschi, L., Becagli, P., Bellotti, G., Blotta, C., Bruno, G., Cappuccini, A., Caramatti, S., Cariolato, M. P., Castellana, M., Castellani, L., Catania, R., Chielli, A., Chinellato, A., Ciaccia, A., Clerici, E., Cocci, A., Costanzo, G., D’Ercole, F., De Stefano, G., Decè, F., Di Cicco, N., Di Marco, A., Donati Sarti, C., Draghi, E., Dusi, G., Esposito, V., Ferraro, L., Ferretti, A., Ferri, E., Foggetti, L., Foglia, A., Fonzi, E., Frau, G., Fuoco, M. R., Furci, G., Gallo, L., Garra, V., Giannini, A., Gris, A., Iacovino, R., Interrigi, R., Joppi, R., Laner, B., La Fortezza, G., La Padula, A., Lista, M. R., Lupi, G., Maffei, D., Maggioni, G., Magnani, L., Marrazzo, E., Marcon, L., Marinò, V., Maroni, A., Martinelli, C., Mastandrea, E., Mastropierro, F., Meo, A. T., Mero, P., Minesso, E., Moschetta, V., Mosele, E., Nanni, C., Negretti, A., Nisticò, C., Orsini, A., Osti, M., Pacilli, M. C., Pennestre, C., Picerno, G., Piol, K., Pivano, L., Pizzuti, E., Poggi, L., Poidomani, I., Pozzetto, M., Presti, M. L., Ravani, R., Recalenda, V., Romagnuolo, F., Rossignoli, S., Rossin, E., Sabatella, C., Sacco, F., Sanità, F., Sansone, E., Servadei, F., Sisto, M. T., Sorio, A., Sorrentino, A., Spinelli, E., Spolaor, A., Squillacioti, A., Stella, P., Talerico, A., Todisco, C., Vadino, M., Zuliani, C., and Risk & Prevention Collaborative Group

Published
2017
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36. Characterization of Ion-Beam-Sputtered AlF3 Thin Films for Gravitational-Wave Interferometers

Author

Bischi, M., primary, Amato, A., additional, Bazzan, M., additional, Cagnoli, G., additional, Canepa, M., additional, Favaro, G., additional, Forest, D., additional, Gobbi, P., additional, Granata, M., additional, Guidi, G.M., additional, Maggioni, G., additional, Martelli, F., additional, Menotta, M., additional, Montani, M., additional, Piergiovanni, F., additional, and Valentini, L., additional

Published
2022
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37. Measurement and Simulation of Mechanical and Optical Properties of Sputtered Amorphous SiC Coatings

Author

Favaro, G., primary, Bazzan, M., additional, Amato, A., additional, Arciprete, F., additional, Cesarini, E., additional, Corso, A.J., additional, De Matteis, F., additional, Dao, T.H., additional, Granata, M., additional, Honrado-Benítez, C., additional, Gutiérrez-Luna, N., additional, Larruquert, J.I., additional, Lorenzin, G., additional, Lumaca, D., additional, Maggioni, G., additional, Magnozzi, M., additional, Pelizzo, M.G., additional, Placidi, E., additional, Prosposito, P., additional, and Puosi, F., additional

Published
2022
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44. Searching for new trends and dynamics in Labour Market: a statistical approach for the recruiting process

Author

Maggioni, G, Mariani, P, Marletta, A, Zenga, M, Lombardo, R, Camminatiello, I, Simonacci, V, Maggioni, G, Mariani, P, Marletta, A, and Zenga, M

Subjects
SECS-S/03 - STATISTICA ECONOMICA, Italian labour market, Job matching, Skills analysis
Abstract

Il contributo analizza il ruolo delle skills richieste nel mercato del lavoro italiano usando un nuovo dataset creato combinando dati provenienti da fonti aziendali ed esterne. Da un punto di vista metodologico, una Conjoint analysis e` stata implementata ai dati per stimare le utilita parziali legate alle competenze pi ` u` richieste definendone la migliore combinazione desiderata in un’ottica di reclutamento. In particolare, i profili dei lavoratori reclutati da The Adecco Group in Italia nel periodo 2016-2021 sono stati analizzati alla ricerca di trend e dinamiche negli ultimi anni In this paper, the roles of the most requested skills for getting a job in Italian Labour market are investigated using a new data set created by combining information from business and external sources. From a methodological point of view, a Conjoint analysis is performed to estimate the partial utilities for the most requested skills and their importance in defining the best combinations of skills to match job requirements. In particular, the profiles of workers recruited by The Adecco Group in Italy in the period 2016-2021 have been analysed detecting dynamics and movements during last years.

Published
2022

46. Optical and Mechanical Properties of Ion-Beam-Sputtered Mg F 2 Thin Films for Gravitational-Wave Interferometers

Author

Granata, M., Amato, A., Bischi, M., Bazzan, M., Cagnoli, G., Canepa, M., Chicoine, M., Di Michele, A., Favaro, G., Forest, D., Guidi, G. M., Maggioni, G., Martelli, F., Menotta, M., Montani, M., Piergiovanni, F., Schiettekatte, F., Granata, M., Amato, A., Bischi, M., Bazzan, M., Cagnoli, G., Canepa, M., Chicoine, M., Di Michele, A., Favaro, G., Forest, D., Guidi, G. M., Maggioni, G., Martelli, F., Menotta, M., Montani, M., Piergiovanni, F., and Schiettekatte, F.

Abstract

Brownian thermal noise associated with highly reflective coatings is a fundamental limit for several precision experiments, including gravitational-wave detectors. Research is currently ongoing to find coatings with low thermal noise that also fulfill strict optical requirements such as low absorption and scatter. We report on the optical and mechanical properties of ion-beam-sputtered magnesium fluoride thin films and we discuss the application of such coatings in current and future gravitational-wave detectors.

Published
2022

47. The Association of Waminoa with Reef Corals in Singapore and Its Impact on Putative Immune- and Stress-Response Genes

Author

Maggioni, G, Huang, D, Maggioni, D, Jain, S, Quek, R, Poquita-Du, R, Montano, S, Montalbetti, E, Seveso, D, Huang, DW, Jain, SS, Quek, RZB, Poquita-Du, RC, Maggioni, G, Huang, D, Maggioni, D, Jain, S, Quek, R, Poquita-Du, R, Montano, S, Montalbetti, E, Seveso, D, Huang, DW, Jain, SS, Quek, RZB, and Poquita-Du, RC

Abstract

Waminoa spp. are acoel flatworms mainly found as ectosymbionts on scleractinian corals. Although Waminoa could potentially represent a threat to their hosts, not enough information is available yet regarding their ecology and effect on the coral. Here, the Waminoa sp.–coral association was analyzed in Singapore reefs to determine the prevalence, host range, and preference, as well as the flatworm abundance on the coral surface. Moreover, the impact of Waminoa sp. on the expression of putative immune-and stress-response genes (C-type lectin, C3, Hsp70 and Actin) was exam-ined in the coral Lobophyllia radians. The association prevalence was high (10.4%), especially in sites with lower sedimentation and turbidity. Waminoa sp. showed a wide host range, being found on 17 coral genera, many of which are new association records. However, only few coral genera, mostly characterized by massive or laminar morphologies appeared to be preferred hosts. Waminoa sp. individuals displayed variable patterns of coral surface coverage and an unequal distribution among different host taxa, possibly related to the different coral growth forms. A down-regulation of the expression of all the analyzed genes was recorded in L. radians portions colonized by Waminoa individuals compared to those without. This indicated that Waminoa sp. could affect components of the immune system and the cellular homeostasis of the coral, also inhibiting its growth. Therefore, Waminoa sp. could represent a potential further threat for coral communities already subjected to multiple stressors.

Published
2022

48. Searching for new trends and dynamics in Labour Market: a statistical approach for the recruiting process

Author

Lombardo, R, Camminatiello, I, Simonacci, V, Maggioni, G, Mariani, P, Marletta, A, Zenga, M, Lombardo, R, Camminatiello, I, Simonacci, V, Maggioni, G, Mariani, P, Marletta, A, and Zenga, M

Abstract

Il contributo analizza il ruolo delle skills richieste nel mercato del lavoro italiano usando un nuovo dataset creato combinando dati provenienti da fonti aziendali ed esterne. Da un punto di vista metodologico, una Conjoint analysis e` stata implementata ai dati per stimare le utilita parziali legate alle competenze pi ` u` richieste definendone la migliore combinazione desiderata in un’ottica di reclutamento. In particolare, i profili dei lavoratori reclutati da The Adecco Group in Italia nel periodo 2016-2021 sono stati analizzati alla ricerca di trend e dinamiche negli ultimi anni, In this paper, the roles of the most requested skills for getting a job in Italian Labour market are investigated using a new data set created by combining information from business and external sources. From a methodological point of view, a Conjoint analysis is performed to estimate the partial utilities for the most requested skills and their importance in defining the best combinations of skills to match job requirements. In particular, the profiles of workers recruited by The Adecco Group in Italy in the period 2016-2021 have been analysed detecting dynamics and movements during last years.

Published
2022

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