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346 results on '"Magee H"'

1. A Systematic Spectroscopic X-Ray Study of Stellar Coronae with XMM-Newton: Early Results

Author

Guedel, M., Audard, M., Smith, K. W., Sres, A., Escoda, C., Wehrli, R., Guinan, E. F., Ribas, I., Beasley, A. J., Mewe, R., Raassen, A. J. J., Behar, E., and Magee, H.

Subjects
Astrophysics
Abstract

We have been conducting a comprehensive survey of stellar coronae with the XMM-Newton Reflection Grating Spectrometers during the commissioning, calibration, verification, and guaranteed time phases of the mission, accompanied by simultaneous observations with the EPIC cameras and, for several targets, with the radio VLA and/or the VLBA. The principal aim of this project is threefold: i) To understand stellar coronal structure and composition by studying systematics in the coronae of stars with widely different levels of magnetic activity; ii) to investigate heating and particle acceleration physics during flares, their role in the overall coronal energy budget, and their possible role in the quiescent stellar emission; iii) to probe stellar coronal evolution by studying solar analogs of different ages. We report early results from this project., Comment: to appear in The Twelfth Cool Stars, Stellar Systems and the Sun, eds. A. Brown, T.R. Ayres, G.M. Harper, (Boulder: Univ. of Colorado), in press

Published
2001

2. XMM-Newton Probes the Solar Past: Coronal Abundances of Solar Analogs at Different Ages

Author

Guedel, M., Audard, M., Sres, A., Wehrli, R., Behar, E., Mewe, R., Raassen, A. J. J., and Magee, H.

Subjects
Astrophysics
Abstract

We present an X-ray spectral analysis of four solar analogs with different ages and magnetic activity levels. We find largely different coronal compositions. The most active stars tend to show an ``Inverse First Ionization Potential'' (IFIP) effect, i.e., elements with low FIP are underabundant. Less active stars tend to the opposite effect, with relative overabundances of low-FIP elements. Equivalent Chandra results are presented that support these results., Comment: to appear in 35th ESLAB Symposium "Stellar Coronae in the Chandra and XMM-Newton Era", eds. F. Favata & J.J. Drake (San Francisco: ASP), in press

Published
2001

4. A CLN6-CRMP2-KLC4 complex regulates anterograde ER-derived vesicle trafficking in cortical neurites

Author

Koh, SY, primary, Cain, JT, additional, Magee, H, additional, White, KA, additional, Rechtzigel, M, additional, Meyerink, B, additional, Leppert, H, additional, Timm, DJ, additional, Morgan, JP, additional, Johnson, TB, additional, Grove, B, additional, Khanna, R, additional, Hensley, K, additional, Brudvig, J, additional, and Weimer, JM, additional

Published
2021
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9. Bi-allelic variants in SPATA5L1 lead to intellectual disability, spastic-dystonic cerebral palsy, epilepsy, and hearing loss

Author

Richard, E. M., Bakhtiari, S., Marsh, A. P. L., Kaiyrzhanov, R., Wagner, M., Shetty, S., Pagnozzi, A., Nordlie, S. M., Guida, B. S., Cornejo, P., Magee, H., Liu, J., Norton, B. Y., Webster, R. I., Worgan, L., Hakonarson, H., Li, J., Guo, Y., Jain, M., Blesson, A., Rodan, L. H., Abbott, M. -A., Comi, A., Cohen, J. S., Alhaddad, B., Meitinger, T., Lenz, D., Ziegler, A., Kotzaeridou, U., Brunet, T., Chassevent, A., Smith-Hicks, C., Ekstein, J., Weiden, T., Hahn, A., Zharkinbekova, N., Turnpenny, P., Tucci, A., Yelton, M., Horvath, R., Gungor, S., Hiz, S., Oktay, Y., Lochmuller, H., Zollino, M., Morleo, M., Marangi, G., Nigro, V., Torella, A., Pinelli, M., Amenta, S., Husain, R. A., Grossmann, B., Rapp, M., Steen, C., Marquardt, I., Grimmel, M., Grasshoff, U., Korenke, G. C., Owczarek-Lipska, M., Neidhardt, J., Radio, F. C., Mancini, C., Claps Sepulveda, D. J., McWalter, K., Begtrup, A., Crunk, A., Guillen Sacoto, M. J., Person, R., Schnur, R. E., Mancardi, M. M., Kreuder, F., Striano, P., Zara, F., Chung, W. K., Marks, W. A., van Eyk, C. L., Webber, D. L., Corbett, M. A., Harper, K., Berry, J. G., MacLennan, A. H., Gecz, J., Tartaglia, M., Salpietro, V., Christodoulou, J., Kaslin, J., Padilla-Lopez, S., Bilguvar, K., Munchau, A., Ahmed, Z. M., Hufnagel, R. B., Fahey, M. C., Maroofian, R., Houlden, H., Sticht, H., Mane, S. M., Rad, A., Vona, B., Jin, S. C., Haack, T. B., Makowski, C., Hirsch, Y., Riazuddin, S., Kruer, M. C., Zollino M. (ORCID:0000-0003-4871-9519), Marangi G. (ORCID:0000-0002-6898-8882), Richard, E. M., Bakhtiari, S., Marsh, A. P. L., Kaiyrzhanov, R., Wagner, M., Shetty, S., Pagnozzi, A., Nordlie, S. M., Guida, B. S., Cornejo, P., Magee, H., Liu, J., Norton, B. Y., Webster, R. I., Worgan, L., Hakonarson, H., Li, J., Guo, Y., Jain, M., Blesson, A., Rodan, L. H., Abbott, M. -A., Comi, A., Cohen, J. S., Alhaddad, B., Meitinger, T., Lenz, D., Ziegler, A., Kotzaeridou, U., Brunet, T., Chassevent, A., Smith-Hicks, C., Ekstein, J., Weiden, T., Hahn, A., Zharkinbekova, N., Turnpenny, P., Tucci, A., Yelton, M., Horvath, R., Gungor, S., Hiz, S., Oktay, Y., Lochmuller, H., Zollino, M., Morleo, M., Marangi, G., Nigro, V., Torella, A., Pinelli, M., Amenta, S., Husain, R. A., Grossmann, B., Rapp, M., Steen, C., Marquardt, I., Grimmel, M., Grasshoff, U., Korenke, G. C., Owczarek-Lipska, M., Neidhardt, J., Radio, F. C., Mancini, C., Claps Sepulveda, D. J., McWalter, K., Begtrup, A., Crunk, A., Guillen Sacoto, M. J., Person, R., Schnur, R. E., Mancardi, M. M., Kreuder, F., Striano, P., Zara, F., Chung, W. K., Marks, W. A., van Eyk, C. L., Webber, D. L., Corbett, M. A., Harper, K., Berry, J. G., MacLennan, A. H., Gecz, J., Tartaglia, M., Salpietro, V., Christodoulou, J., Kaslin, J., Padilla-Lopez, S., Bilguvar, K., Munchau, A., Ahmed, Z. M., Hufnagel, R. B., Fahey, M. C., Maroofian, R., Houlden, H., Sticht, H., Mane, S. M., Rad, A., Vona, B., Jin, S. C., Haack, T. B., Makowski, C., Hirsch, Y., Riazuddin, S., Kruer, M. C., Zollino M. (ORCID:0000-0003-4871-9519), and Marangi G. (ORCID:0000-0002-6898-8882)

Abstract

Spermatogenesis-associated 5 like 1 (SPATA5L1) represents an orphan gene encoding a protein of unknown function. We report 28 bi-allelic variants in SPATA5L1 associated with sensorineural hearing loss in 47 individuals from 28 (26 unrelated) families. In addition, 25/47 affected individuals (53%) presented with microcephaly, developmental delay/intellectual disability, cerebral palsy, and/or epilepsy. Modeling indicated damaging effect of variants on the protein, largely via destabilizing effects on protein domains. Brain imaging revealed diminished cerebral volume, thin corpus callosum, and periventricular leukomalacia, and quantitative volumetry demonstrated significantly diminished white matter volumes in several individuals. Immunofluorescent imaging in rat hippocampal neurons revealed localization of Spata5l1 in neuronal and glial cell nuclei and more prominent expression in neurons. In the rodent inner ear, Spata5l1 is expressed in the neurosensory hair cells and inner ear supporting cells. Transcriptomic analysis performed with fibroblasts from affected individuals was able to distinguish affected from controls by principal components. Analysis of differentially expressed genes and networks suggested a role for SPATA5L1 in cell surface adhesion receptor function, intracellular focal adhesions, and DNA replication and mitosis. Collectively, our results indicate that bi-allelic SPATA5L1 variants lead to a human disease characterized by sensorineural hearing loss (SNHL) with or without a nonprogressive mixed neurodevelopmental phenotype.

Published
2021

17. Irish Association for Cancer Research: Proceedings of annual scientific meeting held at Kinsale on April 15–16th, 1994

Author

Lawler, M., Locasciulli, A., Bacigalupo, A., Humphries, P., Ljungman, P., McCann, S. R., Nolan, N., McDermott, E. W., Reynolds, J. R., McCann, A., Rafferty, R., Sweeney, P., Carney, D., O’Higgins, N. J., Duffy, M. J., Gardiner, C., Reen, D. J., O’Connell, M. A., Kelleher, D., Hall, N., O’Neill, L. A. J., Long, A., McCarthy, J. V., Fernandes, R. S., Cotter, T. G., Ryan, E., Kitching, A., MacMathuna, P., Mulligan, E., Merriman, R., Dervan, P., Kelly, P., Gorey, T. F., Lennon, J. R., Crowe, J., Bennett, M. A., Kay, E. W., Curran, B., O’Donoghue, D. P., Leader, M., Croke, D. T., O’Connor, J. M., McKelvey-Martin, V. J., McKenna, P. G., O’Riordan, J. M., Tobin, A., O’Mahoney, M., Keogh, F. M., O’Riordan, J., McNamara, C., McEneaney, P., Daly, P. A., Farrell, M., Young, S., Gibbons, D., McCarthy, P., Mulcahy, H., Parfrey, N. A., Sheahan, K., Lambkin, H., Mothersill, C., Chin, D., Sheehan, K., Kelehan, P., Parfrey, N., Morrin, M., Khan, F., Delaney, P., Rowan, D. M., Orminston, W. J., Donnellan, P. P., Khalid, A., Kerin, M., O’Hanlon, D. M., Kent, P., Given, H. F., Kennedy, S. M., McGeoch, G., Spurr, N. K., Barrett, J., O’Sullivan, G., Collins, J. K., Willcocks, T., Kennedy, S., Dolan, J., Gallagher, W., McDermott, E., O’Higgins, N., Hagan, R., McManus, R., Ormiston, W., Daly, P., Sheils, O., McDermott, M., O’Briain, D. S., Maher, D., Costello, P., Flanagan, F., Stack, J., Ennis, J., Grimes, H., Yanni, A., Harrison, M., Lowry, W. S., Russell, S. E. H., Atkinson, R. J., White, P., Hickey, I., Bell, D. W., Biggart, D., Doyle, J., Staunton, M. J., Gaffney, E. F., Dervan, P. A., McCabe, M. M., Fennelly, J. J., Carney, D. N., O’Reilly, M., McMahon, J. N., Moriarty, M., Hurson, B., O’Neill, A. J., Magee, H., O’Loughlin, J., Dervan, P. A., Cremin, P., Orminston, W., McCarthy, J., Redmond, P., Duggan, S., Rea, S., Bouchier-Hayes, D., O’Donnell, J., Duggan, C., Crown, J., Bermingham, D., Nugent, A., Fleming, C., Crosby, P., Wolff, S., McCarthy, D., Walsh, C. Barry, Cassidy, M., Husain, S., Kay, E., Thornhilll, M., Whelan, D., Barry, D., Turner, M., Prenderville, W., Murphy, F., Prendiville, W., Gibson, G., O’Grady, T., Carmody, M., Donohoe, J., Walshe, J., Murphy, G. M., O’Donoghue, J., Kerin, K., Ahern, S., Molloy, K., Goulden, N., Pamphilon, D. H., O’Connell, M., Power, C., Leroux, A., Perricaudet, M., Walls, D., Britton, F., Brennan, L., Barnett, Y. A., Madden, B., Wakelin, L. P. G., Loughrey, H. C., Corley, P., Redmond, H. P., Watson, R. W. G., Keogh, I., O’Hanlon, D., Walsh, S., Callaghan, J., McNamara, M., Benedict-Smith, A., Barnes, C., Neylon, D., Fenton, M., Searcey, M., Topham, C. M., Wakelin, L. G., Howarth, N. M., Purohit, A., Reed, M. J., Potter, B. V. L., Hatton, W. J., McKerr, G., Harvey, D., Carson, J., Hannigan, B. M., McCarthy, P. J., McClean, S., Hill, B. T., Costelloe, C., Denny, W. A., Fingleton, B., McDonnell, S., Butler, M., Corbally, N., Dervan, P. A., Stephens, J. F., Martin, G., McGirl, A., Lawlor, E., Gardiner, N., Lynch, S., Arce, M. de, O’Brien, F., Duggan, A., O’Herlihy, S., Shanahan, F., O’Keeffe, G., McCann, S., Sweeney, K., Neill, A. O., Pamphilon, D., Sheridan, M., Reid, I., Seymour, C. B., Walshe, T., Hennessy, T. P., O’Mahony, A., O’Connell’, J., Lawlor, C., Nolan, S., Morrisey, D., Pedlow, P. J., Walsh, M., Lowry, S. W., McAleer, J. J. A., McKeown, S. R., Afrasiabi, M., Lappin, T. R. J., Joiner, B., Hirst, K. V., Hirst, D. G., Sweeney, E., VanderSpek, J., Murphy, J., and Foss, F.

Published
1995
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19. Irish association for cancer research: Proceedings of the 1993 IACR Annual Scientific Meeting held April 2-3, 1993 in Kilkenny

Author

Gannon, F., Forde, R. C., Nester, P. V., Webb, P., McCaffrey, J., Fennelly, J. J., McCarthy, D., Halligan, J., Crosby, P., Long, A., Kelleher, D., Keane, J., O’Riordan, T., O’Briain, D. S., Daly, P. A., Sheahan, R., Jawas, A. M., O’Reane, J. C., Murnane, M. J., Corbally, N., Devaney, D., Grogan, L., Dervan, P. A., Carney, D. N., Duggan, A., O’Brien, F., O’Sullivan, G., Collins, J. K., Long, H. A., Conway, D. J., Mercer, P. M., Murphy, D., Stokes, M., Sheahan, K., O’Higgins, N. J., Smyth, P. P. A., O’Connell, M. A., Long, A., O’Neill, L., Kelleher, D., Nugent, A., Gallagher, J., Dolan, J., Bermingham, D., McDermott, E., Fennelly, J. J., Higgins, N. O., Duffy, M. J., Mercer, P. M., McDermott, E. W., Stokes, M., Murphy, D. S., Sharp, M., Duffy, M. J., Murphy, J. J., O’Higgins, N., Daly, P. A., Ormiston, W., Donnellan, P., McManus, R., Ashraf, M. S., Brady, J., Breatnach, F., Deasy, P. F., O’Meara., A., Mercer, P. M., Doran, M., McDermott, E. W. M., Smyth, P. P. A., Cassidy, M., Cross, K. S., O’Higgins., N. J., Devaney, D., Corbally, N., Carney, D. N., Dervan., P. A., Gardiner, N., Lawler, M., Humphries, P., McCann., S. R., Mahon, T., O’Neill., L. A. J., Lawler, M., Humphries, P., McCann., S. R., McManus, R., Shiels, O., Gaffney, E., Daly., P. A., Hollywood, D. P., Hurst., W. C., Donnellan, P., Daly., P. A., Lyng, F. M., Mothersill, C., Cottell, D. C., Trosko, J. E., O’Keefe, G., McCann, S., Sweeney., K., Sheridan, M., Mothersill, C., Seymour, C. B., Harney., J., Grehan, D., O’Briain, D. S., Walshe, T., Hickey, K., Hennessy, T., Mercer, P., Reynolds, J., McDermott, E. W., Stokes, M., Murphy, D., Cross, S., O’Higgins., N., Bermingham, D., Fennelly, J. J., O’Higgins, N., Duffy, M. J., Morrissey, D., Lynch, D., Collins, J. K., O’Sullivan., G., Verhaegen, S., Cotter., T., McGahon, A., Cotter, K., Green, D., Cotter., T., McCarthy, D., Samson, D., Evans, M., Treleaven, J., Barrett, J., McMahon, J., Gaffney, E. F., Grehan, D., Sheils, O., McCabe, M., Dervan, P. A., Lambkin, H., Mothersill, C., Kelehane, P., Corbally, N., Devaney, D., Grogan, L., Dervan, P. A., Carney, D. N., Glynn, J. M., Green, D. R., Cotter, T. G., O’Mahony, A. M., Collins, J. K., O’Sullivan, G. C., Molloy, K. M., Lawler, M., Humphries, P., McCann, S. R., O’Riordan, J., Molloy, K., Corbally, N., Devaney, D., McShane, I., McCann, S. R., Kelleher, L., Magee, H., Carney, D. N., Dervan, P. A., O’Byrne, K., Lyons, D., O’Toole, E., O’Donnell, C., O’Hare, N., Freyne, P., Clancy, L., Ennis, J., Prichard, J., McGovern, E., Luke, D., Carney, D., Kenealy, M. R., Keaveney, M., Nestor, P., Gannon, F., Duggan, S., Redmond, H. P., McCarthy, J., Watson, R. G. W., Croke, D. T., Burke, P., Bouchier-Hayes, D., McCarthy, J., Redmond, H. P., Duggan, S., Watson, R. W. G., Bouchier-Hayes, D., O’Donnell, R., McCarthy, M., O’Donovan, N., O’Sullivan, G., Collins., J. K., O’Connell, J., Phelan, D., Hanvajanawong, C., O’Sullivan, G., Collins, J. K., Morrin, M., Kelly, M., Khan, F., Barrett, N., Delaney, P., O’Mahony, A. M., Collins, J. K., and O’Sullivan, G. C.

Published
1994
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20. Irish association for cancer research: Proceedings of Annual Scientific Meeting, University College, Cork, 30th–31st March, 1990.

Author

Moriarty, M., Maher, M., Morton, G., Flavin, A., Mooney, E., Neilan, J., Nestor, P., Horgan, P. G., Kerin, M., Waldron, D., Gannon, F., Given, H., McCann, A. H., Dervan, P. A., Codd, M. B., Guillick, W. J., Carney, D. N., Horgan, P. G., O’Brien, D. P., Waldron, D. J., Mooney, E., McGuire, M., Given, H. F., Dolan, Jane, O’Hora, A., Droogan, Olivia, Curran, Bernadette, Henry, K., Leader, Mary, Meehan, S., Magee, H., Carney, D., Dervan, P., Lawler, M., McCann, S. R., Humphries, P., Barrett, J., O’Sullivan, G., Collins, J. K., Williams, N., Daly, J., Herlyn, M., Corbally, N., Sweeney, E., Dervan, P., Carney, D. N., Sheppard, M. N., Hamid, Q., Corrin, B., Weedle, Roisin M., Cotter, T. G., Wilkinson, Y. A., McKenna, P. G., Hahnvajanawong, C., O’Sullivan, G., McCarthy, M., Collins, J. K., Atkinson, R. J., Pedlow, P., McQuaid, S., Johnson, P., Stuart, J., O’Meara, A., Russell, S. E. H., White, P. M., Atkinson, R. J., Hickey, G. I., Pomeroy, M., Prosser, E., Barker, F., Casey, M., Carroll, K., O’Kennedy, R., Duffy, G., Fennelly, J. J., Duffy, M. J., Reilly, D., Fennelly, J. J., O’Higgins, N., Rochfort, H., O’Neal, K. L., Hoper, M., Odling-Smee, G. W., Abram, W. P., McKenna, P. G., Mooney, E., Brougham, C., Horgan, P., Waldron, D., O’Brien, D., Kerin, M., Heyden, D. R., Given, H. F., Lanigan, D., McLean, P., Murphy, D., Donovan, M. G., Curran, B., Leader, M., Martin, Angela, Clynes, M., Graham, D., Curran, B., McQuaid, S., Dorman, T., Breathnach, F., Fitzgerald, R. J., Leader, M., O’Meara, A., Lennon, S. V., Martin, S. J., Cotter, T. G., Ryan, L., Kilfeather, S. A., O’Malley, K., Nolan, K. B., Croke, D. T., Helene, C., Browne, P. V., Lawler, M., McCann, S. R., Clarke, E., McCann, S. R., Glynn, J., Cotter, K., Shine, M., Cotter, T., Sweeney, E., Dervan, P., Carney, D. N., McKelvey, V. J., Stefani, L. A. J., McKenna, P. G., Ranjbar, S., Cromie, E., Eason, S., Hannigan, B. M., Corbett, A., O’Sullivan, G., Collins, J. K., O’Brien, F., O’Sullivan, G., Collins, J. K., Carney, D. N., Grogan, L., Leonard, N., Morton, G., Flavin, A., Moriarty, M., Foley-Nolan, D., McCann, A., Carney, D. N., Fennelly, J. J., Jones, Mary, Garrett, C., Pomeroy, Maeve, Brennan, D. P., and Powell, D.

Published
1991
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26. The Nutrition Question

Author

Anderson, G. C., Magee, H. E., Hopkins, F. Gowland, Cathcart, E. P., Cowell, S. J., Crowden, Guy P., Mellaney, E., and Mottram, V. H.

Published
1934

38. Doctors in satirical prints and cartoons

Author

Magee, H. Reginald

Subjects
Caricatures and cartoons -- Analysis, Cartooning -- Analysis, Medical care -- Australia, Medical care -- Evaluation, Physicians -- Portrayals, Physicians -- Evaluation, Health
Abstract

The article examines how doctors and the medical practice has become an object of ridicule in satirical prints and cartoons in relation to treatment and fees charged.

Published
2007

39. Proceedings of the Irish Cardiac Society 1988

Author

Elborn, J. S., Stanford, C. F., McNair, W., Nicholls, D. P., McDonald, K., Conroy, R., McWilliams, E., Maurer, B., Moore, D. P., Gueret, P., Crean, P. A., Gearty, G. F., Sullivan, P. A., Daly, B., O’Connor, R., O’Neill, S., Kinirons, M., Lynch, T., O’Callaghan, D., Ismail, S., Ohman, M., Horgan, J. H., Brannigan, M., Clarke, R. J., Graham, I., McLoughlin, M., Martin, E. A., Dean, G., O’Keeffe, D. B., Allen, D., Richardson, S. G., Morton, P., Murtagh, J. G., Scott, M. E., Crick, J., Murphy, P. P., O’Keefe, D. B., Anderson, Virginia, Kelly, Pauline, Cullen, S., Denham, B., Duff, D., Ward, O. C., McNeill, A. J., Cunningham, S. R., Flannery, D. J., Shannon, J. S., Dalzell, G. W. N., Tsoi, E., Wilson, C. M., Campbell, N. P. S., Patterson, G. C., Khan, M. M., Webb, S. W., Adgey, A. A., Moore, K., McNair, W. S., Anderson, C., Datzell, G. W. N., Pruznia, S., Magee, H., Anderson, J., MacLennan, B. A., Maguire, C., McCann, H. A., Chandrasekaran, K., Hoffman, E. A., Sinak, L. J., Kinter, T. M., Greenleaf, J. F., O’Neill, P. G., Charlat, M. L., Roberts, R., Bolli, R., Puleo, P. R., Rokey, R., Walsh, K. P., Williams, T. D. M., Lightman, S. L., Sutton, R., Gilligan, D., Walsh, M., Hackett, D., Davies, G., Maseri, A., McKenna, W., Kenny, D., McShane, M. A., Mulholland, H. C., Craig, B. G., Murray, D. P., O’Brien, T., and O’Sullivan, D. J.

Published
1988
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40. Image analysis as an adjunct to manual HER-2 immunohistochemical review: a diagnostic tool to standardize interpretation.

Author

Dobson, L, Conway, C, Hanley, A, Johnson, A, Costello, S, O'Grady, A, Connolly, Y, Magee, H, O'Shea, D, Jeffers, M, Kay, E, Dobson, L, Conway, C, Hanley, A, Johnson, A, Costello, S, O'Grady, A, Connolly, Y, Magee, H, O'Shea, D, Jeffers, M, and Kay, E

Abstract

AIMS: Accurate determination of HER-2 status is critical to identify patients for whom trastuzumab treatment will be of benefit. Although the recommended primary method of evaluation is immunohistochemistry, numerous reports of variability in interpretation have raised uncertainty about the reliability of results. Recent guidelines have suggested that image analysis could be an effective tool for achieving consistent interpretation, and this study aimed to assess whether this technology has potential as a diagnostic support tool. METHODS AND RESULTS: Across a cohort of 275 cases, image analysis could accurately classify HER-2 status, with 91% agreement between computer-aided classification and the pathology review. Assessment of the continuity of membranous immunoreactivity in addition to intensity of reactivity was critical to distinguish between negative and equivocal cases and enabled image analysis to report a lower referral rate of cases for confirmatory fluorescence in situ hybridization (FISH) testing. An excellent concordance rate of 95% was observed between FISH and the automated review across 136 informative cases. CONCLUSIONS: This study has validated that image analysis can robustly and accurately evaluate HER-2 status in immunohistochemically stained tissue. Based on these findings, image analysis has great potential as a diagnostic support tool for pathologists and biomedical scientists, and may significantly improve the standardization of HER-2 testing by providing a quantitative reference method for interpretation.

Published
2010

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