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Due to unsuitable design decisions, manufactured products are often unable to be remanufactured at the end of their lifetimes. This publication provides comprehensive guidelines for the design of products to facilitate remanufacturing across its various process steps: testing, cleaning, disassembly, reconditioning, and reassembly. By identifying and addressing specific challenges within these stages, products can be optimized to meet the needs or constraints of remanufacturing. Based on an extensive literature review, general product design guidelines for remanufacturing are organized into eight categories: identifiability, accessibility, modularity, manageability, standardization, separability, longevity, and cleanability. Additionally, the guidelines are specified for an integrated remanufacturing system and used to assess the product design of a water meter.

Remanufacturing has received increased attention for its potential to reduce resource consumption and emissions in the manufacturing sector. Remanufacturing involves restoring and potentially upgrading end-of-life products to their original functionality and warranty. However, several challenges such as uncertainty about the timing and volume of returns, varying conditions and requirements for remanufacturing, reduced batch sizes, and increased workload variability hinder the efficiency of remanufacturing. Adaptable systems provide possibilities to manage these uncertainties and complexities. This paper aims to assess whether adaptability is beneficial for remanufacturing and to provide initial guidance on selecting appropriate implementation options. A framework is developed based on findings from a literature review, followed by analysis and systematization. This framework links remanufacturing influences and challenges to adaptability characteristics and their enablers, illustrating how these challenges can be addressed. The resulting framework demonstrates that some of the challenges in remanufacturing can be alleviated by increasing adaptability.

Artykuł jest omówieniem monografii pt. Komunikacja naukowa w humanistyce pod redakcją Emanuela Kulczyckiego. Zawiera ona trzynaście artykułów koncentrujących się wokół zagadnień takich jak: cechy nauki i cechy humanistyki, otwartość w nauce, komunikacja naukowców oraz ocena dorobku naukowców.

Recultivated landfills, despite remedial actions, may pose a threat to human health and the environment, and therefore require long-term monitoring. The aim of the work was to investigate the impact of recultivation treatments on changes in the physical and chemical properties of soils in the vicinity of a landfill for waste other than hazardous and neutral. In order to carry out the work, drillings were made around the tested landfill, from which samples were taken and selected physical and chemical properties were determined, including substances causing risks that are particularly important for the protection of the earth's surface. The tested soils were characterized by a neutral and alkaline reaction and a high degree of saturation of the sorption complex with exchangeable basic cations after the use of dust and ash as a recultivation material. Leaks and leachate accumulation were found in the northern part of the facility. The permissible metal contents for industrial areas (group IV) and forest areas (group III) were not exceeded. In the northern part of the landfill area, the permissible content of cadmium was exceeded, while in the southern part, the permissible content of zinc, lead and cadmium was exceeded for agricultural areas (group II). The use of dust and ashes for the recultivation of the landfill in its southern part limited the migration of pollutants deeper into the profile and resulted in an improvement in the physical and chemical properties of the tested soils. The conclusion stated that there is a need to undertake further remediation activities and monitoring studies in order to minimize potential migration of pollutants into the soil and water environment, posing a threat to human health and the environment.

The COVID-19 pandemic and its consequences, including social isolation, movement restrictions and work instability have altered many people’s nutritional behaviors and daily lifestyle. The aim of the study was to evaluate the influence of the COVID-19 pandemic on selected eating habits, physical activity and daily lifestyle changes of Polish adults (n = 145). The self-designed and anonymous questionnaire was available online from the 1 May 2021 to the 15 May 2021. In general, 60% of respondents declared that the COVID-19 pandemic did not affect their dietary habits, whereas 26% of surveyed individuals answered in the affirmative. The effect of the COVID-19 pandemic on changing dietary habits was differentiated by age (Pearson’s χ2 = 12.604; p = 0.0134). The number of meals consumed by respondents per day differed across gender groups (Pearson’s χ2 = 9.653; df = 4; p = 0.0466). An increase in body weight during the COVID-19 pandemic was reported by 43% of women and 7.6% of surveyed men. Additionally, hybrid working women declared most often an increase in body mass independent of age, education level and living place. Moreover, the majority of respondents who reported the effect of the pandemic on changing dietary habits also declared more frequent sweets consumption. The study revealed that respondents who stated more frequent sweets consumption during the COVID-19 pandemic were more likely associated with an increase in body mass (OR = 6.75, 95% CI, 6.75–91.25). No increase in the consumption of vitamin D, C and Mg supplements and pickled products was found.

Aim: Recently, more attention has been paid to the role of nutritional intervention in preventing the side effects of chemotherapy in oncology patients. Therefore, the aim of the present study was to analyze the effects of oral nutritional supplements on the body composition and biochemical parameters in women with breast cancer receiving postoperative adjuvant chemotherapy. Patients and Methods: The study involved women diagnosed with breast cancer who underwent surgical treatment and were qualified for chemotherapy (doxorubicin and cyclophosphamide). Women were divided into two groups, depending on whether oral nutritional supplements were used during chemotherapy. Anthropometric and biochemical parameters were analyzed twice in all patients: before and after six weeks of chemotherapy. Propensity score (PS) matching was performed to select patients balanced in terms of age, BMI, and clinicopathological features of the tumor. Statistical comparisons were conducted in a propensity-matched cohort of patients. Results: The value of BMI was maintained constant in the supplemented women older than 56 years after six weeks of chemotherapy. Regardless of age in the supplemented women, a significant increase in muscle mass, fat free mass (FFM), and fat free mass index (FFMI) was demonstrated. An increase in fat mass (FM) including visceral fat was observed only in the non-supplemented control. Regardless of age or initial FM, supplemented women exhibited a constant level of albumin. Moreover, in the supplemented women with normal initial FM, the stable values of triglycerides and HDL cholesterol were maintained after six weeks of chemotherapy. Conclusion: The present study demonstrated that oral nutritional supplements could improve body composition and prevent hypoalbuminemia and lipid abnormalities in women with breast cancer undergoing chemotherapy.

The article describes how to conduct the assessment of the earth’s surface contamination in industrial areas in terms of new legislation. Identification of contaminated sites is carried out during the five-step procedure by which there are examined physical and chemical properties of substances posing the risk and environmental conditions of the studied area in the context of possible migration of pollutants in the environment. In a case of substances for which no permitted limits were specified in the Polish legal system, the identification of contaminated sites is carried out on the basis of risk exposure to human health and the environment.

This article shows a way of dealing with the industrial areas, where historical contamination of the earth’s surface occurred, together with an indication of the proper remediation method selection. Public Administration authorities, including the Regional Director of Environmental Protection (RDOŚ) and the governor are responsible, among others, for identifying areas where historical contamination or potential historical contamination of the earth's surface occurred. General Director of Environmental Protection is responsible for conducting and updating the registry, which contains information on identified by RDOŚ and district governor contaminated areas. The article discusses also issues related to the duties and responsibilities wielding the earth's surface, as well as the costs of using the environment, taking into account the "polluter pays" principle.

BackgroundThe main aim of present study is to evaluate the potential role of circulating endothelial cells (CECs) and endothelial progenitor cells (CEPCs) – representing specific markers of endothelial damage, in the prediction of left ventricular hypertrophy (LVH) in hypertensive patients categorized into two groups; mild (MH) and resistant hypertension (RH).Materials and MethodsThirty patients with MH and 28 subjects with RH were involved in the study. In both groups, patients were divided into an LVH and non-LVH group. The control group included 33 age and sex-matched normotensive volunteers. Physical examination, laboratory tests and echocardiography were conducted.ResultsIn both the MH and RH group, patients with as well as without LVH demonstrated a higher number of CECs and a lower ratio of CEPCs/CECs as compared to the healthy control. Multiple linear regression analysis showed a positive association of CEPCs with left ventricular mass (LVM) and left ventricular mass index (LVMI), independently of other confounders.ConclusionOur results suggest that endothelial injury observed as an elevated CECs number and its impaired regeneration, reflected by a lowered CEPCs/CECs ratio, precede LVH occurrence and may play a significant role in LVH development regardless of the clinical severity of hypertension. Moreover, independent correlation of CEPCs with echocardiographic (ECG) incidences of LVH suggests their potential use as a screening biomarker to stratify the risk of LVH development.

Harsh pollutants that are illegally disposed in the sewer network may spread beyond the sewer network—e.g., through leakages leading to groundwater reservoirs—and may also impair the correct operation of wastewater treatment plants. Consequently, such pollutants pose serious threats to water bodies, to the natural environment and, therefore, to all life. In this article, we focus on the problem of identifying a wastewater pollutant and localizing its source point in the wastewater network, given a time-series of wastewater measurements collected by sensors positioned across the sewer network. We provide a solution to the problem by solving two linked sub-problems. The first sub-problem concerns the detection and identification of the flowing pollutants in wastewater, i.e., assessing whether a given time-series corresponds to a contamination event and determining what the polluting substance caused it. This problem is solved using random forest classifiers. The second sub-problem relates to the estimation of the distance between the point of measurement and the pollutant source, when considering the outcome of substance identification sub-problem. The XGBoost algorithm is used to predict the distance from the source to the sensor. Both of the models are trained using simulated electrical conductivity and pH measurements of wastewater in sewers of a european city sub-catchment area. Our experiments show that: (a) resulting precision and recall values of the solution to the identification sub-problem can be both as high as 96%, and that (b) the median of the error that is obtained for the estimation of the source location sub-problem can be as low as 6.30 m.

Although the endothelial dysfunction is considered to be implicated in the pathogenesis of chronic venous insufficiency (CVI) the endothelial status in patients with venous disorders is still not fully evaluated. Therefore the aim of the study was to measure the concentration of selected markers of endothelial dysfunction: von Willebrand factor (vWf), soluble P-selectin (sP-selectin), soluble thrombomodulin (sTM) and soluble VE-cadherin (sVE-cadherin) in CVI women who constitute the most numerous group of patients suffering from venous disease.Forty four women with CVI were involved in the study and divided into subgroups based on CEAP classification. Concentration of vWf, sP-selectin, sTM and sVE-cadherin were measured and compared with those obtained in 25 healthy age and sex-matched women.It was found that the concentration of sTM increased and sVEcadherin decreased along with disease severity in CVI women. A significant rise of sTM was observed especially in CVI women, with the highest inflammation status reflected by hsCRP or elastase concentration, and in CVI women with a high oxidative stress manifested by an increased plasma MDA. A significant fall of circulating sVE-cadherin was reported in CVI women with moderate to highest intensity of inflammation and oxidative stress. There was no change in vWF and sP-selectin concentration at any stage of CVI severity.The results of the present study demonstrate the presence of endothelial dysfunction in women suffering from CVI which seems to progress with the disease severity and may be associated with inflammation and enhanced oxidative stress.

The aim of the present study was to evaluate advanced glycation end products (AGEs) and soluble form of receptor RAGE (sRAGE) concentrations as well as the AGEs/sRAGE ratio in mild (MH) and resistant (RH) hypertensive patients in comparison with normotensive individuals. We also evaluated the association between AGEs, sRAGE as well as AGEs/sRAGE ratio and circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPCs). The MH group consisted of 30 patients, whereas 30 patients were classified for the RH group. The control group (C) included 25 normotensive volunteers. AGEs and sRAGE were measured using enzyme-linked-immunosorbent assay (ELISA). The multicolor flow cytometry was used for analysis of CECs and CEPCs. Significantly higher levels of AGEs in RH cohort were observed as compared to C cohort. Furthermore, significantly lower sRAGE levels as well as a higher AGEs/sRAGE ratio were observed between MH and RH cohorts. Significant correlations were found in the MH cohort for sRAGE and CECs, and CEPCs. The elevation of AGEs levels suggests that oxidative modification of proteins occurs in hypertension pathogenesis. The decrease in sRAGE levels and elevation of the AGEs/sRAGE ratio in MH and RH groups may suggest that hypertensive patients are less protected against the side effects of AGEs as a consequence of an insufficient competitive role of sRAGE against the AGEs-RAGE axis. Finally, it may be concluded that the level of AGEs may be an independent predictor of the condition and function of the endothelium. Furthermore, sRAGE may be classified as a potential biomarker of inflammation and endothelium dysfunction.