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33 results on '"Magarik, Jordan A."'

7. Saline Versus Balanced Crystalloids for Adults With Aneurysmal Subarachnoid Hemorrhage: A Subgroup Analysis of the SMART Trial

Author

Mistry, Akshitkumar M., primary, Magarik, Jordan A., additional, Feldman, Michael J., additional, Wang, Li, additional, Lindsell, Christopher J., additional, Fusco, Matthew R., additional, Chitale, Rohan V., additional, Bernard, Gordon R., additional, Self, Wesley H., additional, Rice, Todd W., additional, Hughes, Christopher G., additional, Mistry, Eva A., additional, and Semler, Matthew W., additional

Published
2022
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10. L-citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets

Author

Ananthakrishnan, Madhumita, Barr, Frederick E., Summar, Marshall L., Smith, Heidi A., Kaplowitz, Mark, Cunningham, Gary, Magarik, Jordan, Zhang, Yongmei, and Fike, Candice D.

Subjects
Pulmonary hypertension -- Development and progression, Pulmonary hypertension -- Research, Citrulline -- Physiological aspects, Citrulline -- Research, Animal models in research -- Usage, Animal models in research -- Physiological aspects, Hypoxia -- Models, Hypoxia -- Physiological aspects, Hypoxia -- Research, Nitric oxide -- Physiological aspects, Nitric oxide -- Research, Biological sciences
Abstract

Newborn piglets develop pulmonary hypertension and have diminished pulmonary vascular nitric oxide (NO) production when exposed to chronic hypoxia. NO is produced by endothelial NO synthase (eNOS) in the pulmonary vascular endothelium using L-arginine as a substrate and producing L-citrulline as a byproduct. L-Citrulline is metabolized to L-arginine by two enzymes that are colocated with eNOS in pulmonary vascular endothelial cells. The purpose of this study was to determine whether oral supplementation with L-citrulline during exposure of newborn piglets to 10 days of chronic hypoxia would prevent the development of pulmonary hypertension and increase pulmonary NO production. A total of 17 hypoxic and 17 normoxic control piglets were studied. Six of the 17 hypoxic piglets were supplemented with oral L-citrulline starting on the first day of hypoxia. L-Citrulline supplementation was provided orally twice a day. After 10 days of hypoxia or normoxia, the animals were anesthetized, hemodynamic measurements were performed, and the lungs were perfused in situ. Pulmonary arterial pressure and pulmonary vascular resistance were significantly lower in hypoxic animals treated with L-citrulline compared with untreated hypoxic animals (P < 0.001). In vivo exhaled NO production (P = 0.03) and nitrite/nitrate accumulation in the perfusate of isolated lungs (P = 0.04) were significantly higher in L-citrulline-treated hypoxic animals compared with untreated hypoxic animals. L-Citrulline supplementation ameliorated the development of pulmonary hypertension and increased NO production in piglets exposed to chronic hypoxia. We speculate that L-citrulline may benefit neonates exposed to prolonged periods of hypoxia from cardiac or pulmonary causes. nitric oxide synthase; nitric oxide; L-arginine recycling

Published
2009

14. Bone Cement Cranioplasty Reduces Cerebrospinal Fluid Leak Rate after Microvascular Decompression: A Single-Institutional Experience.

Author

Wolfson, Daniel I., Magarik, Jordan A., Godil, Saniya S., Shah, Hamid M., Neimat, Joseph S., Konrad, Peter E., and Englot, Dario J.

Subjects
*CEREBROSPINAL fluid leak, *BONE cements, *RHINORRHEA, *CEREBROSPINAL fluid, *CRANIAL nerves, *BODY mass index, *CEREBROSPINAL fluid shunts, *LOGISTIC regression analysis
Abstract

Background  Microvascular decompression (MVD) is a common surgical treatment for cranial nerve compression, though cerebrospinal fluid (CSF) leak is a known complication of this procedure. Bone cement cranioplasty may reduce rates of CSF leak. Objective  To compare rates of CSF leak before and after implementation of bone cement cranioplasty for the reconstruction of cranial defects after MVD. Methods  Retrospective chart review was performed of patients who underwent MVD through retrosigmoid craniectomy for cranial nerve compression at a single institution from 1998 to 2017. Study variables included patient demographics, medical history, type of closure, and postoperative complications such as CSF leak, meningitis, lumbar drain placement, and ventriculoperitoneal shunt insertion. Cement and noncement closure groups were compared, and predictors of CSF leak were assessed using a multivariate logistic regression model. Results  A total of 547 patients treated by 10 neurosurgeons were followed up for more than 20 years, of whom 288 (52.7%) received cement cranioplasty and 259 (47.3%) did not. Baseline comorbidities were not significantly different between groups. CSF leak rate was significantly lower in the cement group than in the noncement group (4.5 vs. 14.3%; p  < 0.001). This was associated with significantly fewer patients developing postoperative meningitis (0.7 vs. 5.2%; p  = 0.003). Multiple logistic regression model demonstrated noncement closure as the only independent predictor of CSF leak (odds ratio: 3.55; 95% CI: 1.78–7.06; p  < 0.001). Conclusion  CSF leak is a well-known complication after MVD. Bone cement cranioplasty significantly reduces the incidence of postoperative CSF leak and other complications. Modifiable risk factors such as body mass index were not associated with the development of CSF leak. [ABSTRACT FROM AUTHOR]

Published
2021
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19. Evaluation of previously embolized intracranial aneurysms: inter-and intra-rater reliability among neurosurgeons and interventional neuroradiologists

Author

Zuckerman, Scott L, primary, Lakomkin, Nikita, additional, Magarik, Jordan A, additional, Vargas, Jan, additional, Stephens, Marcus, additional, Akinpelu, Babatunde, additional, Spiotta, Alejandro M, additional, Ahmed, Azam, additional, Arthur, Adam S, additional, Fiorella, David, additional, Hanel, Ricardo, additional, Hirsch, Joshua A, additional, Hui, Ferdinand K, additional, James, Robert F, additional, Kallmes, David F, additional, Meyers, Philip M, additional, Niemann, David B, additional, Rasmussen, Peter, additional, Turner, Raymond D, additional, Welch, Babu G, additional, and Mocco, J, additional

Published
2017
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20. Evaluation of previously embolized intracranial aneurysms: inter-and intra-rater reliability among neurosurgeons and interventional neuroradiologists.

Author

Zuckerman, Scott L., Lakomkin, Nikita, Magarik, Jordan A., Vargas, Jan, Stephens, Marcus, Akinpelu, Babatunde, Spiotta, Alejandro M., Ahmed, Azam, Arthur, Adam S., Fiorella, David, Hanel, Ricardo, Hirsch, Joshua A., Hui, Ferdinand K., James, Robert F., Kallmes, David F., Meyers, Philip M., Niemann, David B., Rasmussen, Peter, Turner, Raymond D., and Welch, Babu G.

Subjects
ANGIOGRAPHY, INTRACRANIAL aneurysms, NEURORADIOLOGY, NEUROSURGERY, RADIOLOGISTS, REOPERATION, RESEARCH evaluation, STATISTICS, SURGEONS, THERAPEUTIC embolization, DECISION making in clinical medicine, INTER-observer reliability, DESCRIPTIVE statistics, INTRACLASS correlation, THERAPEUTICS
Abstract

Background The angiographic evaluation of previously coiled aneurysms can be difficult yet remains critical for determining re-treatment. Objective The main objective of this study was to determine the inter-rater reliability for both the raymond scale and per cent embolization among a group of neurointerventionalists evaluating previously embolized aneurysms. Methods A panel of 15 neurointerventionalists examined 92 distinct cases of immediate post-coil embolization and 1 year post-embolization angiographs. Each case was presented four times throughout the study, along with alterations in demographics in order to evaluate intra-rater reliability. All respondents were asked to provide the per cent embolization (0-100%) and raymond scale grade (1-3) for each aneurysm. Inter-rater reliability was evaluated by computing weighted kappa values (for the raymond scale) and intraclass correlation coefficients (ICC) for per cent embolization. results 10 neurosurgeons and 5 interventional neuroradiologists evaluated 368 simulated cases. The agreement among all readers employing the raymond scale was fair (Κ=0.35) while concordance in per cent embolization was good (ICC=0.64). Clinicians with fewer than 10 years of experience demonstrated a significantly greater level of agreement than the group with greater than 10 years (Κ=0.39 and ICC=0.70 vs Κ=0.28 and ICC=0.58). When the same aneurysm was presented multiple times, clinicians demonstrated excellent consistency when assessing per cent embolization (ICC=0.82), but moderate agreement when employing the raymond classification (Κ=0.58). Conclusions Identifying the per cent embolization in previously coiled aneurysms resulted in good inter- and intra-rater agreement, regardless of years of experience. The strong agreement among providers employing per cent embolization may make it a valuable tool for embolization assessment in this patient population. [ABSTRACT FROM AUTHOR]

Published
2018
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21. The CT-Defined Hyperdense Arterial Sign as a Marker for Acute Intracerebral Large Vessel Occlusion.

Author

Jaims Lim, Magarik, Jordan A., Froehler, Michael T., and Lim, Jaims

Subjects
*INTRACEREBRAL hematoma, *CEREBRAL hemorrhage, *ARTERIAL occlusions, *COMPUTED tomography, *COMPUTER-assisted image analysis (Medicine), *MAGNETIC resonance imaging, *PREVENTION
Abstract

Background and Purpose: To determine the sensitivity and specificity of the hyperdense artery sign (HAS) on thin-slice non-contrast computed tomography (NCCT), combined with brief clinical history, as an indicator for large vessel occlusion (LVO) in the setting of acute ischemic stroke.Methods: Ninety-nine LVO and 102 non-LVO acute ischemic stroke patients were retrospectively identified from a prospective database at a single institution. After reviewing each patient's neurologic presentation based on his or her initial National Institute of Health Stroke Scale (NIHSS) and neurologic evaluation, all thin (1 mm) and thick (5 mm) NCCT scans were reviewed for the HAS. Analysis of sensitivity and specificity was conducted to determine the utility of the HAS sign as a reliable marker for LVO in acute ischemic stroke patients.Results: Of the 99 LVO stroke patients, 66 HASs were identified on NCCT. Of the 102 non-LVO patients, 18 false-positive HASs were identified. The sensitivity and specificity of the HAS, respectively, was 67% and 82%. By anatomic distribution, the sensitivity of identifying basilar artery occlusions was 75%, and the sensitivity of identifying middle cerebral artery (MCA) M1 branch occlusions was 76%. Among patients with an NIHSS > 10, the sensitivity was 79%; whereas sensitivity was 50% if NIHSS was ≤ 10.Conclusions: The HAS on thin-slice NCCT has a reasonably high sensitivity and specificity for identifying LVO in acute ischemic stroke patients presenting with an NIHSS > 10 and suspected MCA M1 or basilar artery occlusion. [ABSTRACT FROM AUTHOR]

Published
2018
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22. The Medical University of South Carolina’s Comprehensive Stroke Program: Changing What’s Possible in Stroke Care Across South Carolina

Author

Magarik, Jordan A, Jauch, Edward C, Patel, Sunil J, Adams, Robert J, Turner, Raymond D, Chaudry, M Imran, Chalela, Julio A, Hays, Angela, Chimowitz, Marc I, Turan, Tanya N, Holmstedt, Christine A, Debenham, Ellen, Lackland, Daniel T, and Turk, Aquilla S

Subjects
Diagnostic Imaging, Stroke, Risk Factors, Incidence, South Carolina, Humans, Mass Screening, Article
Published
2012

23. Utilization of Pipeline embolization device for treatment of ruptured intracranial aneurysms: US multicenter experience

Author

Lin, Ning, primary, Brouillard, Adam M, additional, Keigher, Kiffon M, additional, Lopes, Demetrius K, additional, Binning, Mandy J, additional, Liebman, Kenneth M, additional, Veznedaroglu, Erol, additional, Magarik, Jordan A, additional, Mocco, J, additional, Duckworth, Edward A, additional, Arthur, Adam S, additional, Ringer, Andrew J, additional, Snyder, Kenneth V, additional, Levy, Elad I, additional, and Siddiqui, Adnan H, additional

Published
2014
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24. Contributors

Author

Aarabi, Bizhan, Abbott, Rick, Abd-El-Barr, Muhammad M., Abel, Taylor J., Abruzzo, Todd A., Acar, Feridun, Achey, Rebecca L., Ackerman, Paul D., Adams, Hadie, Adappa, Nithin D., Adelson, P. David, Aguirre-Padilla, David H., Ahmed, Raheel, Ahn, Edward S., Ailon, Tamir T., Ain, Michael C., Aisiku, Imoigele P., Alaraj, Ali, AlBakry, Amr, Albuquerque, Felipe C., Alexander, Brian M., Alexander, Michael J., Alexandrov, Andrei V., Ali, Zarina S., Al-Khalili, Kenan, Al-Mefty, Ossama, Almefty, Kaith K., Almefty, Rami, Alterman, Ron L., Amenta, Peter S., Ames, Christopher P., Amin-Hanjani, Sepideh, Ammirati, Mario, Andaluz, Norberto, Anderson, Richard C.E., Andrade, Pablo, Angevine, Peter D., Ansari, Shaheryar F., Ares, William J., Arle, Jeffrey E., Armonda, Rocco A., Arnaout, Omar, Arnaud, Eric, Arnold, Paul M., Assina, Rachid, Aszmann, Oskar C., Attenello, Frank J., III, Badhiwala, Jetan H., Baehring, Joachim M., Baggott, Christopher D., Bagić, Anto, Bahgat, Diaa, Bailes, Julian E., Bain, Mark, Ball, Perry A., Baltuch, Gordon H., Baraban, Scott C., Barak, Tanyeri, Barani, Igor J., Barbagallo, Giuseppe M.V., Barbaro, Nicholas M., Barker, Frederick G., II, Barnett, Gene H., Barone, Constance M., Barrow, Daniel Louis, Bassani, Luigi, Batchelor, Tracy T., Batista, Nuno, Batjer, H. Hunt, Baum, Griffin R., Beattie, Michael S., Beaumont, Andrew, Becker, Danielle A., Beckman, Joshua M., Becske, Tibor, Bederson, Joshua B., Beisse, Rudolf W., Bekelis, Kimon, Bell, Randy S., Belzberg, Allan J., Benarroch, Eduardo E., Bendok, Bernard R., Benet, Arnau, Berenstein, Alejandro, Berger, Mitchel S., Bergsneider, Marvin, Bertalanffy, Helmut, Bhatnagar, Saurabha, Bi, Wenya Linda, Birk, Harjus Singh, Bishop, Allen T., Blakeley, Jaishri O., Blomstedt, Patric, Bolinger, Bryan D., Bonney, Phillip A., Boomsaad, Zackary E., Boop, Frederick A., Borg, Nicholas, Boszczyk, Bronek M., Botelho, Ricardo Vieira, Bou-Haidar, Pascal, Bowyer, Susan M., Bragg, Taryn McFadden, Brem, Henry, Brem, Steven, Bresnahan, Jacqueline C., Brinkmann, Benjamin H., Brînzeu, Andrei, Britz, Gavin W., Brockmeyer, Douglas L., Browd, Samuel R., Brown, Desmond A., Brown, Martin, Brown, Matthew T., Brown, Robert D., Jr., Bruce, Jeffrey N., Brunstrom-Hernandez, Janice E., Brunswick, Andrew, Buell, Thomas J., Bullock, M. Ross, Burchiel, Kim J., Burrows, Anthony M., Bydon, Mohamad, Byrne, Richard W., Cahill, Daniel P., Cahill, Kevin S., Calcagnotto, Maria Elisa, Caplan, Justin M., Cascino, Gregory D., Castinetti, Frederic, Cawley, C. Michael, Cernak, Ibolja, Certo, Francesco, Cetas, Justin S., Chan, Michael D., Chanda, Amitabha, Chang, Edward F., Chang, Steven D., Charbel, Fady T., Chari, Aswin, Chaudhary, Navjot, Chauvel, Patrick, Chen, Kevin S., Chen, Liang, Cheng, Joseph S., Cheng, Yuwei, Cheung, Kenneth M.C., Chiocca, E. Antonio, Cho, Catherine, Chou, Dean, Choudhri, Omar, Christian, Cindy W., Claassen, Jan, Claus, Elizabeth B., Cleary, Daniel R., Cohen, Alan R., Collins, John, Connolly, E. Sander, Jr., Cooke, Jonathon, Coppens, Jeroen R., Corcos, Daniel M., Coric, Domagoj, Cornips, Erwin M.J., Cosgrove, G. Rees, Couldwell, William T., Crino, Peter B., Crofton, Andrew, Cullen, D. Kacy, Curry, Brian P., da Silva, Erasmo Barros, Jr., Dailey, Andrew T., Dallapiazza, Robert F., Dalyai, Richard Tyler, Danan, Deepa, Daniels, David J., Darsaut, Tim E., Dash, Alexander, Dashnaw, Matthew L., David, Carlos A., David, David J., Day, Arthur L., De la Garza-Ramos, Rafael, De Salles, Antonio A.F., Dea, Nicolas, Decker, Matthew, Del Brutto, Oscar H., Delman, Bradley N., DeLong, Mahlon R., DeMonte, Franco, Deogaonkar, Milind, Desai, Arati, Desai, Virendra R., Di Rocco, Federico, Diebo, Bassel G., DiLuna, Michael L., DiMeco, Francesco, Dirks, Peter, Dlouhy, Brian J., Doshi, Amish H., Drake, James M., Drofa, Alexander, Ducruet, Andrew F., Duffau, Hugues, Duhaime, Ann-Christine, Dumont, Aaron S., Dunn, Gavin P., Dunn, Ian F., Dusick, Joshua R., Eberwine, James H., Eboli, Paula, Eckardt, Gerald W., Edwards, Michael S.B., Edwards, Richard J., Elder, J. Bradley, Elhammady, Mohamed Samy A., Elias, W. Jeffrey, Ellis, Jason A., Elmadhoun, Tarek M.I., Emch, Todd M., Emerson, Samuel, Ene, Chibawanye, Englot, Dario J., Eskandari, Ramin, Ewend, Matthew G., Fakurnejad, Shayan, Falavigna, Asdrubal, Fan, Yi, Farina, Dario, Farrell, Christopher J., Fehlings, Michael G., Feigin, Valery, Feldman, Eva L., Feldstein, Neil, Feng, James E., Fenno, Lief E., Ferguson, Sherise D., de Oliveira, Matheus Fernandes, Figueroa, Javier M., Figueroa, Juan J., Filler, Aaron G., Findlay, J. Max, Finn, Michael A., Finnell, Richard H., Fisher, Charles G., Flamm, Eugene S., Flemming, Kelly D., Flores-Sarnat, Laura, Follett, Kenneth A., Foreman, Paul M., Foster, Kimberly A., Freeze, Benjamin S., Fried, Itzhak, Friedlander, Robert M., Fry, Donald E., Fu, Kai-Ming Gregory, Fulkerson, Daniel H., Fuller, Gregory N., Fusco, Matthew R., Galvan, Adriana, Gandhoke, Gurpreet S., Garcia, Hector H., Gardner, Paul A., Garton, Hugh, Gavin, Cormac G., Gaynor, Brandon G., George, Timothy M., Georgoulis, George, Gerard, Carter S., Gerke, Luke, Gerosa, Massimo, Gerszten, Kristina, Gerszten, Peter C., Ghatan, Saadi, Ghobrial, George M., Ghosh, Chaitali, Giacobbe, Peter, Gianaris, Thomas J., Giglio, Pierre, Gilad, Ronit, Gjedde, Albert H., Göçmen, Selçuk, Godzik, Jakub, Goel, Atul, Gogela, Steven L., Gokaslan, Ziya L., Goldstein, Hannah E., Golfinos, John G., Gologorsky, Yakov, Golshani, Kiarash, Gonzalez, Nestor R., Gonzalez-Martinez, Jorge, Goodden, John, Goodman, J. Clay, Goodrich, James Tait, Goodwin, C. Rory, Gordon, David S., Gorgulho, Alessandra, Goumnerova, Liliana C., Goyal, Anshit, Grady, M. Sean, Grafman, Jordan H., Gragnaniello, Cristian, Grande, Andrew W., Grant, Gerald A., Grant, Ryan A., Griessenauer, Christoph J., Groff, Michael W., Gross, Robert E., Grossberg, Jonathan A., Grossman, Aaron W., Grossman, Rachel, Groves, Mari L., Gruenberg, Marcelo Fernando, Gunel, Jennifer Moliterno, Günel, Murat, Gupta, Nalin, Haddad, Georges F., Haglund, Michael M., Haines, Stephen J., Haldeman, Clayton L., Halvorson, Kyle G., Hamberger, Marla J., Haq, Ihtsham U., Haranhalli, Neil, Harbaugh, Robert E., Hariz, Marwan, Harrigan, Mark R., Harrop, James S., Härtl, Roger, Harwell, Daniel M., Hasan, David M., Hashemiyoon, Rowshanak, Hassaneen, Wael, Hawryluk, Gregory W.J., Hayward, Richard David, He, Lucy, Healy, Andrew T., Heary, Robert F., Heimberger, Amy B., Prof. Dr. med., Heini, Heinricher, Mary M., Henrikson, Karl J., Heros, Roberto C., Herrup, Karl, Hervey-Jumper, Shawn, Heuer, Gregory G., Higuchi, Yoshinori, Gilmer, Holly S., Hirsch, Lawrence J., Hoffer, S. Alan, Holland, Eric, Holland, Ryan, Hongo, Kazuhiro, Horisawa, Shiro, Horner, Philip J., Houseman, Clifford M., Howard, Matthew A., III, Hsueh, Brian, Huang, Judy, Huang, Michael C., Huang, Raymond Y., Hudgins, Eric, Hunt, Matthew A., Hurlbert, R. John, Hutchinson, Peter J., Huttner, Anita, Hwang, Steven W., Iliff, Jeffrey J., Ingram, Susan L., Isaias, Ioannis U., Iskandar, Bermans J., Iyer, Aditya K., Jacob, R. Patrick, Jada, Ajit, Jadhav, Ashutosh P., Jaffer, Hayder, Jakacki, Regina I., Jallo, George I., Jallo, Jack I., Jamil, Osama, Jane, John A., Jr., Jane, John A., Sr., Janigro, Damir, Jankowitz, Brian T., Jea, Andrew H., Jeelani, Owase, Jehi, Lara, Jellinger, Kurt A., Jho, Diana, Jimenez, David F., Jo, Jasmin T., Johanson, Conrad E., Johnson, Luke A., Jones, Adrian C., Jones, Kristen E., Joseph, Jacob R., Jovin, Tudor G., Kalani, M. Yashar S., Kalanithi, Paul S.A., Kalfas, Iain H., Kalnins, Aleksandrs Uldis, Kalra, Ricky Raj Singh, Kamath, Ashwin A., Kang, Daniel G., Kang, James D., Kanter, Adam S., Kaplitt, Michael G., Karimi, Reza J., Kasliwal, Manish K., Kawasaki, Hiroto, Kelleher, John Paul, Kellner, Christopher P., Kemeny, Andras A., Kennedy, Benjamin C., Kestle, John R.W., Khan, Imad Saeed, Khan, Nadia, Khurana, Vini G., Kim, Dong Gyu, Kim, Dong H., Kim, Irene, Kim, Jin Wook, Kim, Louis J., Kim, Paul K., Kim, Thomas Aquinas, Kirsch, Wolff, Kitchen, Neil D., Klaas, James P., Klein, Joshua P., Kliot, Michel, Knightly, John J., Knopman, Jared, Ko, Andrew L., Koerner, John D., Kokoszka, Malgosia A., Kolias, Angelos G., Korja, Miikka, Kosztowski, Thomas, Krauss, Joachim K., Krishna, Chandan, Krishna, Vibhor, Krishnaney, Ajit A., Kubben, Pieter L., Kuhn, Jens, Kulkarni, Abhaya V., Kumar, Gomatam R. Vijay, Kuntz, Charles, IV, Kuo, Jeffrey V., Kwan, Kenny, La Marca, Frank, Laack, Nadia N. Issa, Ladha, Alim M., Lafage, Virginie, Lam, Arthur M., Lamki, Tariq, Lang, Frederick F., Lanzino, Giuseppe, Larson, Paul, Lau, Catherine Y., Lau, Darryl, Lavine, Sean D., Lawler, Sean E., Laws, Edward R., Jr., Lawton, Michael T., Laxpati, Nealen G., Lazarus, Joash T., Le, Peter D., Lebed, Brett D., Lee, Cheng-Chia, Lee, Sangmi, Lee, Young M., Lehman, Ronald A., Jr., Lenke, Lawrence G., Leuthardt, Eric C., Levin, Emily Lehmann, Levitt, Michael R., Lewis, Evan M., Li, Dianyou, Liang, Lydia J., Liauw, Jason, Lichtenbaum, Roger, Limbrick, David D., Jr., Lin, Kant Y., Lingsma, Hester F., Linskey, Mark E., Lipsman, Nir, Litvak, Zachary N., Liu, James K., Liu, Kenneth C., Liu, Wei, Lizarraga, Karlo J., Lober, Robert M., Loftus, Christopher M., Lonser, Russell R., Louvi, Angeliki, Lozano, Andres M., Luciano, Mark G., Lukas, Rimas V., Lund, Teija, Ma, Lijun, Ma, Tracy S., Maas, Andrew I.R., Macdonald, R. Loch, Mack, Stephen C., MacLachlan, Lara S., Macyszyn, Luke, Magarik, Jordan A., Maggio, Dominic, Magistretti, Pierre J., Mahaney, Kelly B., Maher, Cormac O., Mahmoodi, Ramin, Mahmoudi, Babak, Malessy, Martijn J.A., Mallucci, Conor, Mangano, Francesco T., Maniker, Allen H., Manley, Geoffrey T., Manolidis, Spiros, Marchac, Daniel, Marchione, Joseph, Marcus, Joshua, Maroon, Joseph C., Martin, Alastair, Martin, Neil A., Mascitelli, Justin R., Mathur, Amit, Maulucci, Christopher M., Mazur, Marcus D., Mazwi, Nicole, McAllister, James P., II, McClain, Craig D., McCutcheon, Ian E., McDougall, Cameron G., McEvoy, Andrew W., McGoldrick, Patricia E., McGovern, Robert A., III, McKhann, Guy M., II, Meaney, David F., Medel, Ricky, Mehta, Minesh P., Melega, William P., Menezes, Arnold H., Mertens, Patrick, Meyer, Fredric B., Meyer, R. Michael, IV, Meyer, Scott A., Meyers, Emma, Meyers, Philip M., Midha, Rajiv, Milano, Jerônimo Buzetti, Miller, Catherine, Miller, Charles A., Miller, Jonathan P., Miller, Neil R., Mirza, Farhan A., Miserocchi, Anna, Misra, Basant K., Missios, Symeon, Miyashiro, Kevin Y., Mizuno, Junichi, Mocco, J., Modic, Michael T., Moeller, Jeremy J., Mokin, Maxim, Monteith, Stephen J., Moon, Karam, Morales-Valero, Saul F., Morcos, Jacques J., Morgan, Michael Kerin, Moses, Ziev B., Moss, S. David, Moussazadeh, Nelson, Muizelaar, J. Paul, Mukherjee, Pratik, Mukundan, Srinivasan, Jr., Mummaneni, Praveen V., Munich, Stephan A., Muraszko, Karin, Murray-Ortiz, Gisela, Mussi, Antônio C.M., Nagel, Sean J., Nagy, Gábor, Najm, Imad M., Nakaji, Peter, Nakajima, Takeshi, Nakashima, Hiroaki, Nater, Anick, Navarro-Ramirez, Rodrigo, Nduom, Edjah K., Nelp, Taylor B., Nerva, John D., Nery, Breno, Newell, David W., Ng, Angela Li Ching, Nicholas, M. Kelly, Niimi, Yasunari, Nimjee, Shahid M., North, Richard B., Nowell, Mark, Nurmikko, Turo J., Nuwer, Marc R., Oakes, W. Jerry, Ochiai, Taku, Ogilvy, Christopher S., Oh, Michael Y., Oh, Nathan, Okonkwo, David O., Okun, Michael S., Oldfield, Edward H., Olivi, Alessandro, O'Neill, Francis, Orgill, Dennis P., Osbun, Joshua W., Özduman, Koray, Pacia, Steven V., Pai, Nikhil S., Pain, Margaret, Palacios, Eva M., Palmer, James N., Pamir, M. Necmettin, Pan, Edward, Panczykowski, David M., Panov, Fedor E., Parajón, Avelino, Paramasivam, Srinivasan, Parent, Andrew D., Park, Michael S., Park, Min S., Park, Paul, Park, T.S., Parsa, Andrew T., Partington, Michael D., Patel, Akash J., Patel, Aman B., Patel, Vimal, Patil, Parag G., Payne, Russell, Penn, Richard Deren, Pennicooke, Brenton H., Perez, Augustus J., Perin, Alessandro, Perlmutter, Joel S., Persing, John A., Petersen, Erika A., Peterson, Eric C., Petraglia, Anthony L., Pham, Martin, Piazza, Matthew A., Piepmeier, Joseph M., Pilcher, Webster H., Pinckard-Dover, Heather N., Pineda, José A., Pinter, Joseph D., Pisapia, Jared M., Pisculli, Mary L., Pittman, Thomas, Pohl, Pedro H.I., Pollack, Ian F., Pollock, Bruce E., Post, Kalmon D., Potter, Wyatt, Potts, Matthew B., Pouratian, Nader, Pradilla, Gustavo, Prager, Briana C., Prestigiacomo, Charles J., Proctor, Mark R., Prolo, Laura M., Prost, Robert W., Puduvalli, Vinay K., Purger, David, Quiñones-Hinojosa, Alfredo, Rahal, Jason Pierce, Ram, Zvi, Ranalli, Nathan J., Rangel-Castilla, Leonardo, Raper, Daniel M.S., Rapoport, Benjamin I., Raskin, Jeffrey S., Raslan, Ahmed M., Rasmussen, Peter, Rasouli, Jonathan, Ravanpay, Ali C., Ravindra, Vijay M., Ray, Wilson Z., Raz, Eytan, Raza, Shaan M., Régis, Jean, Reilly, Peter L., Reith, Florence C.M., Renier, Dominique, Resnick, Daniel K., Reynolds, Renée, Rezai, Ali, Rhines, Laurence D., Rhoton, Albert L., Jr., Ribalta, Teresa, Ricci, Joseph A., Richardson, R. Mark, Riggins, Callen J., Riggins, Gregory J., Riina, Howard A., Rincon-Torroella, Jordina, Ringer, Andrew J., Riva-Cambrin, Jay, Roark, Christopher D., Roberts, David W., Robertson, Claudia S., Robertson, Jon H., Robinson, Shenandoah, Roche, Aidan D., Roche, Pierre-Hugues, Rodríguez-Hernández, Ana, Roguski, Marie, Roland, Jarod L., Rolston, John D., Root, Brandon K., Rosenberg, William S., Rosenow, Joshua M., Rosenthal, Guy, Rosenwasser, Robert H., Rosner, Michael K., Rovner, Eric S., Rucker, Janet C., Russell, Stephen M., Russin, Jonathan J., Rutka, James T., Safain, Mina G., Sagher, Oren, Sahgal, Arjun, Saigal, Rajiv, Saito, Nobuhito, Salminger, Stefan, Samdani, Amer F., Sammartino, Francesco, Sanai, Nader, Sanborn, Matthew R., Sandler, Adam L., Sansur, Charles A., Santarius, Thomas, Santiago, Paul, Santiago-Sim, Teresa, José Santos de Moraes, Osmar, Sarkiss, Christopher A., Sarnat, Harvey B., Sarris, Christina, Sawaya, Raymond, Scheer, Justin K., Scheld, W. Michael, Schiff, Nicholas D., Schlesinger, David J., Schmidt, Meic H., Schmitt, Paul J., Schramm, Johannes, Schwab, Frank J., Sciubba, Daniel M., Scott, R. Michael, Scranton, Robert A., Seifert, Volker, Selden, Nathan R., Sellin, Jonathan N., Selman, Warren R., Serafini, Sandra, Serizawa, Toru, Shaffrey, Christopher I., Sr., Shah, Kushal J., Shah, Lubdha M., Shah, Manish N., Shahlaie, Kiarash, Shapira, Yuval, Shapiro, Maksim, Sharma, Deepak, Sharma, Mayur, Sharma, Mohan Raj, Shaw, Andrew, Sheehan, Jason P., Sheehan, Jonas M., Shiflett, James M., Shilpakar, Sushil Krishna, Shils, Jay L., Shin, Alexander Y., Shin, Samuel S., Siddiqui, Adnan H., Siddiqui, Mustafa S., Silvestri, David M., Sindou, Marc, Singer, Robert J., Singh, Jeffrey M., Singh, Manish K., Sivakumar, Walavan, Slavin, Justin, Smith, Edward R., Smith, Justin S., Smith, Timothy R., Smith, Yoland, Solomon, Robert A., Sonabend, Adam M., Sonntag, Volker K.H., Sorenson, Jeffrey M., Soriano, Sulpicio G., Soriano-Baron, Hector, Souweidane, Mark M., Sowa, Gwendolyn A., Spatola, Giorgio, Spears, Julian, Spencer, Dennis D., Spetzler, Robert F., Spinner, Robert J., St. Clair, Eric G., Starke, Robert M., Starr, Philip, Stefko, S. Tonya, Stein, Sherman C., Steinberg, Gary K., Stephens, Bradley H., Stephens, Frederick L., Stern, Matthew A., Steyerberg, Ewout W., Stieg, Philip E., Stone, Scellig S.D., Strom, Russell G., Strowd, Roy E., III, Sughrue, Michael E., Suh, John H., Suki, Dima, Sulaiman, Wale A.R., Sun, Bomin, Tagliati, Michele, Taira, Takaomi, Takagi, Yasushi, Tamargo, Rafael J., Tanaka, Shota, Tandon, Nitin, Tanweer, Omar, Tate, Jessica A., Tate, Matthew C., Tatsui, Claudio E., Taylor, Blake E.S., Taylor, Michael D., Telian, Steven A., Tempel, Zachary J., Teo, Charles, Tessier, Jeffrey M., Than, Khoi D., Theadom, Alice, Theodore, Nicholas, Thompson, B. Gregory, Jr., Tilton, Ann H., Timmons, Shelly D., Tomycz, Nestor D., Torres-Reveron, Juan, Toth, Gabor, Toussaint, Charles P., Tran, Duc A., Trapp, Bruce D., Tubbs, R. Shane, Tunkel, Allan R., Türe, Ugur, Hassoun Turkmani, Ali, Uribe, Juan S., Ushe, Mwiza, Vaccaro, Alexander R., van den Bent, Martin J., Van Gompel, Jamie J., van Overbeeke, J.J., van Santbrink, Henk, Vasquez, Ciro, Vasudeva, Viren S., Vellimana, Ananth K., Verlicchi, Angela, Vialle, Emiliano, Viapiano, Mariano S., Vira, Shaleen, Virk, Michael S., Visser-Vandewalle, Veerle, Vitek, Jerrold L., Vo, Nam, Vogelbaum, Michael A., Volpini, Matthew, Wackym, P. Ashley, Wadhwa, Rishi, Wainwright, Mark S., Waldau, Ben, Walker, Marion L., Wallace, M. Christopher, Wallace, Scott A., Walsh, Kyle M., Wang, Huan, Wang, Michael Y., Wang, Shelly, Wang, Tony R., Wang, Vincent Y., Wang, Xin, Warnick, Ronald E., Weil, Robert J., Weiner, Howard L., Weingart, Jon D., Weiss, Martin H., Weiss, Nirit, Weller, Michael, Wellons, John C., III, Wen, Hung Tzu, Wen, Patrick Y., West, G. Alexander, White, Jonathan, Whiting, Alexander C., Whiting, Donald M., Wichmann, Thomas, Wildrick, David M., Wilkinson, D. Andrew, Winer, Jesse L., Winfree, Christopher J., Winkler, Ethan A., Winn, H. Richard, Wisoff, Jeffrey H., Witsch, Jens, Wolf, Steven M., Wolfla, Christopher E., Wolinsky, Jean-Paul, Wong, Cyrus C., Wong, Eric T., Wrensch, Margaret R., Wu, Jau-Ching, Xu, Linda Wei, Xu, Zhiyuan, Yan, Carol H., Yap, Edward, Yarbrough, Chester K., Yasuno, Katsuhito, Yavin, Daniel, Yener, Ulaş, Yonekawa, Yasuhiro, Young, Timothy P., Youngblood, Mark W., Youngerman, Brett E., Yu, Jennifer S., Yue, John K., Yuh, Esther L., Zabramski, Joseph M., Zacest, Andrew C., Zacko, J. Christopher, Zada, Gabriel, Zadicario, Eyal, Zadnik, Patricia Leigh, Zafonte, Ross D., Zager, Eric L., Zanotti, Bruno, Zellner, Elizabeth G., Zhan, Shikun, Zhang, Chencheng, Zhang, Xiaoxiao, Zhang, Y. Jonathan, Zisakis, Athanasios K., Zuckerman, Scott L., Zumofen, Daniel W., and Zwienenberg-Lee, Marike

Published
2017
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25. Implementation of an institution-wide acute stroke algorithm: Improving stroke quality metrics.

Author

Zuckerman, Scott L., Magarik, Jordan A., Espaillat, Kiersten B., Kumar, Nishant Ganesh, Bhatia, Ritwik, Dewan, Michael C., Morone, Peter J., Hermann, Lisa D., O'Duffy, Anne E., Riebau, Derek A., Kirshner, Howard S., and Mocco, J.

Subjects
STROKE diagnosis, COMPUTED tomography, EMERGENCY medicine, NEUROSURGERY
Abstract

Background: In May 2012, an updated stroke algorithm was implemented at Vanderbilt University Medical Center. The current study objectives were to: (1) describe the process of implementing a new stroke algorithm and (2) compare pre- and post-algorithm quality improvement (QI) metrics, specificaly door to computed tomography time (DTCT), door to neurology time (DTN), and door to tPA administration time (DTT). Methods: Our institutional stroke algorithm underwent extensive revision, with a focus on removing variability, streamlining care, and improving time delays. The updated stroke algorithm was implemented in May 2012. Three primary stroke QI metrics were evaluated over four separate 3-month time points, one pre- and three post-algorithm periods. Results: The following data points improved after algorithm implementation: average DTCT decreased from 39.9 to 12.8 min (P < 0.001); average DTN decreased from 34.1 to 8.2 min (P ≤ 0.001), and average DTT decreased from 62.5 to 43.5 min (P = 0.17). Conclusion: A new stroke protocol that prioritized neurointervention at our institution resulted in significant lowering in the DTCT and DTN, with a nonsignificant improvement in DTT. [ABSTRACT FROM AUTHOR]

Published
2016
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27. Utilization of CT perfusion patient selection for mechanical thrombectomy irrespective of time: a comparison of functional outcomes and complications

Author

Turk, Aquilla S, primary, Nyberg, Eric MacKenzie, additional, Chaudry, M Imran, additional, Turner, Raymond D, additional, Magarik, Jordan Asher, additional, Nicholas, Joyce S, additional, Holmstedt, Christine A, additional, Chalela, Julio Alejandro, additional, Hays, Angela, additional, Lazaridis, Christos, additional, Chimowitz, Marc I, additional, Turan, Tanya N, additional, Adams, Robert J, additional, and Jauch, Edward C, additional

Published
2012
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28. CT perfusion-guided patient selection for endovascular treatment of acute ischemic stroke is safe and effective

Author

Turk, Aquilla, primary, Magarik, Jordan Asher, additional, Chaudry, Imran, additional, Turner, Raymond D, additional, Nicholas, Joyce, additional, Holmstedt, Christine A, additional, Chalela, Julio, additional, Hays, Angela, additional, Lazaridis, Christos, additional, Jauch, Edward, additional, Chimowitz, Marc, additional, Turan, Tanya, additional, and Adams, Robert, additional

Published
2011
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30. Utilization of Pipeline embolization device for treatment of ruptured intracranial aneurysms: US multicenter experience.

Author

Ning Lin, Brouillard, Adam M., Keigher, Kiffon M., Lopes, Demetrius K., Binning, Mandy J., Liebman, Kenneth M., Veznedaroglu, Erol, Magarik, Jordan A., Mocco, J., Duckworth, Edward A., Arthur, Adam S., Ringer, Andrew J., Snyder, Kenneth V., Levy, Elad I., and Siddiqui, Adnan H.

Subjects
CHI-squared test, INTRACRANIAL aneurysms, MEDICAL cooperation, RESEARCH, RESEARCH funding, RUPTURED aneurysms, T-test (Statistics), THERAPEUTIC embolization, TREATMENT effectiveness, RETROSPECTIVE studies, DATA analysis software, DESCRIPTIVE statistics, DISEASE complications
Abstract

Objective Utilization of the Pipeline embolization device (PED) in complex ruptured aneurysms has not been well studied. We evaluated the safety and effectiveness data from five participating US centers. Methods Records of patients with ruptured cerebral aneurysms who underwent PED treatment between 2011 and 2013 were retrospectively reviewed. Results 26 patients with ruptured aneurysms underwent PED treatment (mean age 51.4 ± 13.2 years;16 women). At presentation, 8 patients (30.8%) had a Hunt-Hess grade of IV or above; 11 required extraventricular drain placement. Aneurysm morphologies were: 8 dissecting, 8 blister-like, 6 fusiform, and 4 saccular. There were 22 anterior circulation and 4 posterior circulation aneurysms. PED deployment was successful in all patients, with adjunctive coiling utilized in 12. Periprocedural complications occurred in 5 (19.2%), including 3 inhospital deaths. 23 patients (88.5%) had postoperative angiography at a mean of 5.9 months: 18 aneurysms (78.3%) were completely occluded, 3 (13.0%) had residual neck filling, and 2 (8.7%) had residual dome filling. All blister-type aneurysms were completely occluded at follow-up. Clinical follow-up was available for an average of 10.1 months (range 2-21 months), with one asymptomatic in-stent stenosis and one asymptomatic thromboembolic stroke noted. Good outcome (modified Rankin Scale (mRS) score of 0-2) was achieved in 20 patients (76.9%), fair (mRS 3-4) in 3 (11.5%), and 3 died (11.5%). Conclusions The PED can be utilized for ruptured aneurysms and is a good option for blister-type aneurysms. However, due to periprocedural complications, it should be reserved for lesions that are difficult to treat by conventional clipping or coiling. [ABSTRACT FROM AUTHOR]

Published
2015
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31. Impact of Fludrocortisone on the Outcomes of Subarachnoid Hemorrhage Patients: A Retrospective Analysis.

Author

Mistry AM, Naidugari J, Feldman MJ, Magarik JA, Ding D, Abecassis IJ, Semler MW, and Rice TW

Abstract

Background: Whether the use of fludrocortisone affects outcomes of patients with aneurysmal subarachnoid hemorrhage (aSAH) and its usage rate in the United States remain unknown., Methods: We conducted a retrospective analysis of 78 consecutive patients with a ruptured aSAH at a single academic center in the United States. The primary outcome was the score on the modified Rankin scale (mRS, range, 0 [no symptoms] to 6 [death]) at 90 days. We adjusted the primary outcome for age, hypertension, aSAH grade, and time from aSAH onset to aneurysm treatment. Secondary outcomes were brain and cardiopulmonary dysfunction events., Results: Among 78 patients at a single center, the median age was 58 years [IQR, 49 to 64.5]; 64% were female, and 41 (53%) received fludrocortisone. The adjusted common odds ratio, aOR, of a proportional odds regression model of fludrocortisone use with mRS was 0.33 (95% CI, 0.14-0.80; P=0.02), with values <1.0 favoring fludrocortisone. Organ-specific dysfunction events were not statistically different: delayed cerebral ischemia (22% vs. 39%, P=0.16); cardiac dysfunction (0% vs. 11%; P=0.10); and pulmonary edema (15% vs. 8%; P=0.59)., Conclusions: The risk of disability or death at 90 days was lower with the use of fludrocortisone in aSAH patients.

Published
2023
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32. Saline versus Balanced Crystalloids for Adults with Aneurysmal Subarachnoid Hemorrhage: A Subgroup Analysis of the SMART Trial.

Author

Mistry AM, Magarik JA, Feldman MJ, Wang L, Lindsell CJ, Fusco MR, Chitale RV, Bernard GR, Self WH, Rice TW, Hughes CG, Mistry EA, and Semler MW

Abstract

Background: Whether the composition of intravenous crystalloid solutions affects outcomes in adults with aneurysmal subarachnoid hemorrhage (aSAH) remains unknown. Therefore, we determined whether the use of saline is associated with lower risk of disability and death in aSAH patients compared to balanced crystalloids., Methods: We conducted a post hoc subgroup analysis of the Isotonic Solutions and Major Adverse Renal Events Trial (SMART), a pragmatic, unblinded, cluster-randomized, multiple-crossover clinical trial that enrolled 15,802 adults between June 2015 and April 2017. We compared intravenous administration of saline to balanced crystalloids in consecutively enrolled aSAH patients aged 18 years or older whose ruptured aneurysm was procedurally secured at a single academic center in the United States. The primary outcome was the score on the modified Rankin scale (mRS, range, 0 [no symptoms] to 6 [death]) at 90 days obtained from a prospective institutional stroke registry. Secondary outcome included death by 90 days. Logistic or proportional odds regression models were used to test for between-group differences adjusted for age, hypertension, aSAH grade, and procedure type., Results: Of the 79 aSAH patients procedurally treated during the SMART study period, 78 were enrolled (median age, 58 years; IQR, 49 to 64.5; 64% female), with 41 (53%) assigned to saline and 37 (47%) to balanced crystalloids. Plasma-Lyte was the primary balanced crystalloid used. Among 72 patients with 90-day mRS assessment, the adjusted common odds ratio, aOR, for mRS was 0.68 (95% CI, 0.28-1.63; P=0.39), with values less than 1.0 favoring saline. By 90 days, 2/39 patients (5%) in the saline group and 9/35 (26%) in the balanced-crystalloids group had died (aOR, 0.06; 95% CI, 0.00-0.50; P=0.02)., Conclusions: Among procedurally treated aSAH patients, the risk of disability or death at 90 days did not significantly differ between saline and balanced crystalloids. Death occurred less frequently with saline than balanced crystalloids.

Published
2022
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