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Your search keyword '"Maffuid, Kaitlyn"' showing total 15 results
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15 results on '"Maffuid, Kaitlyn"'

8. Translational Approach to Predicting the Efficacy of Maraviroc-Based Regimens as HIV Preexposure Prophylaxis

Author

Srinivas, Nithya, primary, Cottrell, Mackenzie, additional, Maffuid, Kaitlyn, additional, Prince, Heather A., additional, Nelson, Julie A. E., additional, White, Nicole, additional, Sykes, Craig, additional, Dellon, Evan S., additional, Madanick, Ryan D., additional, Shaheen, Nicholas J., additional, Gonzalez, Daniel, additional, and Kashuba, Angela D. M., additional

Published
2020
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10. Decreased Tenofovir Diphosphate Concentrations in a Transgender Female Cohort: Implications for Human Immunodeficiency Virus Preexposure Prophylaxis

Author

Cottrell, Mackenzie L, primary, Prince, Heather M A, primary, Schauer, Amanda P, primary, Sykes, Craig, primary, Maffuid, Kaitlyn, primary, Poliseno, Amanda, primary, Chun, Tae-Wook, primary, Huiting, Erin, primary, Stanczyk, Frank Z, primary, Peery, Anne F, primary, Dellon, Evan S, primary, Adams, Jessica L, primary, Gay, Cindy, primary, and Kashuba, Angela D M, primary

Published
2019
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14. Translational Approach to Predicting the Efficacy of Maraviroc-Based Regimens as HIV Preexposure Prophylaxis

Author

Srinivas, Nithya, Cottrell, Mackenzie, Maffuid, Kaitlyn, Prince, Heather A., Nelson, Julie A. E., White, Nicole, Sykes, Craig, Dellon, Evan S., Madanick, Ryan D., Shaheen, Nicholas J., Gonzalez, Daniel, and Kashuba, Angela D. M.

Abstract

Maraviroc-based regimens have been explored as preexposure prophylaxis (PrEP) against human immunodeficiency virus (HIV). In this study, we utilized mucosal tissue drug exposure data, combined with target concentrations generated in vitro, in a pharmacokinetic-pharmacodynamic analysis to predict the effects of drug combinations and adherence on PrEP efficacy. Mucosal tissue concentrations of maraviroc were measured in 24 healthy women.

Published
2019
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15. Utilizing a Proximity Dependent Labeling Strategy to Study Cancer-Immune Intercellular Interactions In Vitro and In Vivo.

Author

Maffuid K and Cao Y

Subjects
Animals, Humans, Mice, Cell Line, Tumor, Cysteine Endopeptidases metabolism, Bacterial Proteins metabolism, Staining and Labeling methods, Neoplasms immunology, Neoplasms pathology, Neoplasms metabolism, Female, Mice, Inbred C57BL, Cell Communication immunology, Tumor Microenvironment immunology, Aminoacyltransferases metabolism
Abstract

Immune cells play a critical role in surveilling and defending against cancer, emphasizing the importance of understanding how they interact and communicate with cancer cells to determine cancer status, treatment response, and the formation of the tumor microenvironment (TME). To this end, we conducted a study demonstrating the effectiveness of an enzyme-mediated intercellular proximity labeling (EXCELL) method, which utilizes a modified version of the sortase A enzyme known as mgSrtA, in detecting and characterizing immune-tumor cell interactions. The mgSrtA enzyme is expressed on the membrane of tumor cells, which is able to label immune cells that interact with tumor cells in a proximity-dependent manner. Our research indicates that the EXCELL technique can detect and characterize immune-tumor cell interactions in a time- and concentration-dependent manner, both in vitro and in vivo, without requiring pre-engineering of the immune cells. We also highlight its ability to detect various types of immune cell subpopulations in vivo that have migrated out of the tumor into the spleen, providing insights into the role of peripheral T-cell recruitment in tumor progression. Overall, our findings suggest that the EXCELL method has great potential for improving our understanding of immune cell dynamics within the TME, ultimately leading to more potent pharmacological effects and cancer immunotherapy strategies. SIGNIFICANCE STATEMENT: The enzyme-mediated intercellular proximity labeling method holds promise for detecting immune cell interactions with cancer cells, both in vitro and in vivo. It has important implications for studying immune tumor cell dynamics and potentially uncovering novel subtypes of immune cells within the tumor microenvironment, both prior to and during immunotherapeutic interventions., (Copyright © 2024 by The American Society for Pharmacology and Experimental Therapeutics.)

Published
2024
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