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262 results on '"Maffia, M."'

11. Na2+-D-glucose cotransport by intestinal BBMVs of the Antartic fish Trematous bernachii

Author

Maffia, M., Acierno, R., Cillo, E., and Storelli, C.

Subjects
Intestines -- Physiological aspects, Fishes -- Physiological aspects, Brush border membrane -- Physiological aspects, Biological sciences
Abstract

The intestinal brush-border membrane vesicles (BBMVs) of Trematous bernachii were isolated to determine the mechanisms of nutrient adsorption and transport in Antarctic fish. Analysis of isolated Trematous bernachii BBMVs based on fluorescence changes and rapid filtration technique indicated a sodium-dependent intestinal nutrient transport mechanism. Furthermore, the intestinal cell membrane of Antarctic teleost also exhibited higher unsaturated/saturated fatty acid ratio compared to eel intestines.

Published
1996

12. Electrogenic, proton-coupled, intestinal dipeptide transport in herbivorous and carnivorous teleosts

Author

Thamotharan, M., Gomme, J., Zonno, V., Maffia, M., Storelli, C., and Ahearn, G.A.

Subjects
Fishes -- Physiological aspects, Peptides -- Physiological aspects, Biological transport -- Physiological aspects, Biological sciences
Abstract

Studies have shown that dipeptide transport in mammalian small intestines and kidney occurs by proton gradient-energized transport systems. In teleosts, the mechanism of dipeptide transport has not been characterized. Experiments on the carnivorous rockfish and herbivorous tilapia using [14C]glycylsarcosine as a marker of dipeptide transport show that gastrointestinal dipeptide transport in fishes requires a proton gradient dependent, electrogenic and sodium independent transport system.

Published
1996

13. Ascorbic acid transport by intestinal brush-border membrane vesicles of the teleost Anguilla anguilla

Author

Maffia, M., Ahearn, G.A., Vilella, S., Zonno, V., and Storelli, C.

Subjects
Anguilla -- Analysis, Brush border membrane -- Research, Biological sciences
Abstract

A transmembrane Na gradient produced L-ascorbate transport by intestinal brush-border membrane vesicles in teleost Anguilla anguilla, while a potassium gradient produced no such effect. L-ascorbate transport was analyzed kinetically to express a nonsaturable transfer component with diffusional permeability, and single sodium influenced the carrier process. L-ascorbate influx was inhibited by D-Isoascorbate. On vitamin administration, an inside-negative membrane potential stimulated +Na-L-ascorbate, confirming its electrogenic character. L-ascorbate transport's Hill analysis revealed the sodium-ascorbate binding ratio to be 2:1.

Published
1993

17. Comparative proteomic profiling of Hodgkin lymphoma cell lines

Author

Vergara, D., primary, Simeone, P., additional, De Matteis, S., additional, Carloni, S., additional, Lanuti, P., additional, Marchisio, M., additional, Miscia, S., additional, Rizzello, A., additional, Napolitano, R., additional, Agostinelli, C., additional, and Maffia, M., additional

Published
2016
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18. Halting pro-survival autophagy by TGFβ inhibition in bone marrow fibroblasts overcomes bortezomib resistance in multiple myeloma patients

Author

Frassanito, M A, primary, De Veirman, K, additional, Desantis, V, additional, Marzo, L Di, additional, Vergara, D, additional, Ruggieri, S, additional, Annese, T, additional, Nico, B, additional, Menu, E, additional, Catacchio, I, additional, Ria, R, additional, Racanelli, V, additional, Maffia, M, additional, Angelucci, E, additional, Derudas, D, additional, Fumarulo, R, additional, Dammacco, F, additional, Ribatti, D, additional, Vanderkerken, K, additional, and Vacca, A, additional

Published
2015
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19. Exposure to Electromagnetic Fields in UHF Band of an Insulin Preparation: Biological Effects

Author

Acierno, R., Riccardis, L., Maffia, M., Luca Mainetti, Patrono, L., Urso, E., Acierno, Raffaele, DE RICCARDIS, L., Maffia, Michele, Mainetti, Luca, Patrono, Luigi, and Urso, Emanuela

Subjects
Insulin Preparation, Biological Effect, Evaluation of Exposure Risk, Reverse Phase-High Pressure Liquid Chromatography, Radio Frequency Identification (RFID)
Abstract

The item-level tracing and tracking requirements are growing more and more in the pharmaceutical sector, where the counterfeiting problem and the significant fragmentation of the market contribute significantly to complicate the scenario. The Radio Frequency Identification (RFID) technology holds the promise to eliminate many of the previous problems. Unfortunately, there are still some barriers limiting the largescale deployment of these innovative technologies. Currently, it is not easy finding an exhaustive analysis about potential effects of exposure to electromagnetic fields of the RFID systems on drugs. This work aimed to evaluate the effects of RFID systems on the molecular structure and potency of a biological drug. In particular, some samples of a commercial human insulin preparation (ActrapidTM) were exposed for different periods to electromagnetic fields generated by RFID devices in UHF band. In order to evaluate both possible alterations of the molecular structure and possible adverse effects on drug performance, the following techniques have been used: Reverse Phase-High Pressure Liquid Chromatography and in vitro cell proliferation assays. The experimental results have shown that the electromagnetic field generated by UHF RFID devices does not cause significant biological effects on ActrapidTM insulin.

Published
2010

20. Lipid and Fatty Acid Compositions of Mytilus galloprovincialis Cultured in the Mar Grande of Taranto (Southern Italy): Feeding Strategies and Trophic Relationships

Author

Prato, E., Danieli, A., Maffia, M., FRANCESCA BIANDOLINO, E., Prato, Danieli, Antonio, Maffia, Michele, and F., Biandolino

Subjects
Seasonal variation, Lipid composition, Trophic markers, Mussel
Abstract

Lipid and fatty acid compositions of Mytilus galloprovincialis cultured in the Mar Grande of Taranto (southern Italy): feeding strategies and trophic relationships. Zoological Studies 49(2): 211-219. Lipid and fatty acid (FA) compositions were determined in the mussel Mytilus galloprovincialis collected from June 2006 to May 2007 in the Mar Grande of Taranto, southern Italy. Total lipids significantly differed throughout the study period (ANOVA, p < 0.05), with higher values in summer (24.7% dry weight (DW)) and the lowest values in winter (3.5% DW). Triacylglycerols (TAGs) were the dominant lipid class in spring and summer accounting for 55.28% and 60.3% of total lipids, respectively, while in the autumn and winter phospholipids (PLs) were considerably greater than TAGs, comprising 55.16% and 47.5% of total lipids, respectively. Cholesterol did not show large variations over the seasons. Predominant FAs were saturated FAs (SAFAs) followed by monounsaturated FAs (MUFAs). The amount of polyunsaturated FAs (PUFAs) was low. The 14:0, 16:0, 18:0, and 22:0 SAFAs, together with 14:1, 16:1 omega 7, 18:1 omega 9, 18:1 omega 7, 20:1 omega 9, and 24:1 omega 9 MUFAs, and the PUFA, non-methylene interrupted dienoic (NMID), were the most abundant FAs. FA biomarkers are frequently used to identify trophic relationships among marine invertebrates. In order to obtain indications on food sources of M. galloprovincialis, a variety of FA ratios and the sum of some FAs were determined. The sum of 18:1 omega 7 + odd-branched FAs indicated a moderate bacterial contribution to the mussel diet. A high 18:1 omega 9/18:1 omega 7 ratio together with a high level of 20:1w9 indicated an animal dietary input. Trophic markers suggested lows contribution of diatoms and dinoflagellates to the diet of M. galloprovincialis.

Published
2010

34. 38 ANTIANGIOGENIC PROPERTIES OF IMMUNOMODULATORY DRUG LENALIDOMIDE IN ENDOTHELIAL CELLS OF PATIENTS WITH ACTIVE MULTIPLE MYELOMA

Author

De Luisi, A., primary, Ferrucci, A., additional, Di Pietro, G., additional, Berardi, S., additional, Basile, A., additional, Ria, R., additional, Ribatti, D., additional, Coluccia, A.M.L., additional, Maffia, M., additional, Ranieri, G., additional, Paradiso, A., additional, Guarini, A., additional, and Vacca, A., additional

Published
2010
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39. Network P2P for Exploring and Visualization of Proteomic Data: Possibility of Handling Data and Analysing Them under Different Perspectives

Author

Mercurio, G., primary, Maglio, S., additional, Agrusti, A., additional, Nunzio, G. De, additional, Cataldo, R., additional, Mitri, I. De, additional, Favetta, M., additional, Massafra, A., additional, Marsella, G., additional, Vergara, D., additional, Maffia, M., additional, Vasilateanu, A., additional, and Serbanati, L. D., additional

Published
2008
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