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1. Contextual factors and G6PD diagnostic testing: a scoping review and evidence and gap map

Author

Timothy Hugh Barker, Grace McKenzie McBride, Mafalda Dias, Carrie Price, and Zachary Munn

Subjects
Malaria, G6PD, Contextual factors, Scoping review, Evidence, Gaps, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Testing for glucose-6-phosphate dehydrogenase (G6PD) deficiency is an important consideration regarding treatment for malaria. G6PD deficiency may lead to haemolytic anaemia during malaria treatment and, therefore, determining G6PD deficiency in malaria treatment strategies is extremely important. Methods This report presents the results of a scoping review and evidence and gap map for consideration by the Guideline Development Group for G6PD near patient tests to support radical cure of Plasmodium vivax. This scoping review has investigated common diagnostic tests for G6PD deficiency and important contextual and additional factors for decision-making. These factors include six of the considerations recommended by the World Health Organization (WHO) handbook for guideline development as important to determining the direction and strength of a recommendation, and included ‘acceptability’, ‘feasibility,’ ‘equity,’ ‘valuation of outcomes,’ ‘gender’ and ‘human rights’. The aim of this scoping review is to inform the direction of future systematic reviews and evidence syntheses, which can then better inform the development of WHO recommendations regarding the use of G6PD deficiency testing as part of malaria treatment strategies. Results A comprehensive search was performed, including published, peer-reviewed literature for any article, of any study design and methodology that investigated G6PD diagnostic tests and the factors of ‘acceptability’, ‘feasibility,’ ‘equity,’ ‘valuation of outcomes,’ ‘gender’ and ‘human rights’. There were 1152 studies identified from the search, of which 14 were determined to be eligible for inclusion into this review. The studies contained data from over 21 unique countries that had considered G6PD diagnostic testing as part of a malaria treatment strategy. The relationship between contextual and additional factors, diagnostic tests for G6PD deficiency and study methodology is presented in an overall evidence and gap, which showed that majority of the evidence was for the contextual factors for diagnostic tests, and the ‘Standard G6PD (SD Biosensor)’ test. Conclusions This scoping review has produced a dynamic evidence and gap map that is reactive to emerging evidence within the field of G6PD diagnostic testing. The evidence and gap map has provided a comprehensive depiction of all the available literature that address the contextual and additional factors important for decision-making, regarding specific G6PD diagnostic tests. The majority of data available investigating the contextual factors of interest relates to quantitative G6PD diagnostic tests. While a formal qualitative synthesis of this data as part of a systematic review is possible, the data may be too heterogenous for this to be appropriate. These results can now be used to inform future direction of WHO Guideline Development Groups for G6PD near patient tests to support radical cure of P. vivax malaria.

Published
2024
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2. Contextual factors related to vector-control interventions for malaria: a scoping review and evidence and gap map protocol [version 1; peer review: 2 approved]

Author

Ellie A. Akl, Carrie Price, Jan Kolaczinki, Danielle Pollock, Sabira Hasanoff, Alinune Nathanael Kabaghe, Mafalda Dias, Raju Kanukula, Timothy Hugh Barker, Grace McKenzie McBride, and Zachary Munn

Subjects
Malaria, vector-control, acceptability, feasibility, valuation of outcomes, contextual factors, eng, Medicine, Science
Abstract

Objective This scoping review will identify existing literature regarding contextual factors relevant to vector-control interventions to prevent malaria. We will use the findings of the scoping review to produce an interactive evidence and gap map. The map will assist in the priority setting, development, and conduct of targeted systematic reviews. These systematic reviews seek to assist the Vector Control and Insecticide Resistance Unit of the World Health Organization’s Global Malaria Programme by informing recommendation development by their Guidelines Development Group. Introduction Malaria contributes substantially to the global burden of disease, with an estimated 247 million cases and 619,000 deaths in 2021. Vector-control is key in reducing malaria transmission. Vector-control interventions directly target the mosquito, reducing the potential for parasite infections. These interventions commonly include insecticides used in indoor residual spraying or insecticide-treated nets and larval source management. Several new vector-control interventions are under evaluation to complement these. In addition to estimating the effects of interventions on health outcomes, it is critical to understand how populations at risk of malaria consider them in terms of their feasibility, acceptability, and values. Inclusion Criteria Eligible studies will have assessed the contextual factors of feasibility or acceptability of the interventions of interest, or the valuation of the outcomes of interests. These assessments will be from the perspective of people who receive (residents) or deliver (workers or technicians) the vector-control intervention for the purpose of preventing malaria. Methods We will conduct this scoping review in accordance with the JBI methodology for scoping reviews and report in line with the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews (PRISMA-ScR). We will construct the evidence and gap map following guidance from the Campbell Collaboration.

Published
2024
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3. Recent Advances in Cell‐Based In Vitro Models to Recreate Human Intestinal Inflammation

Author

Maria Helena Macedo, Mafalda Dias Neto, Lorenzo Pastrana, Catarina Gonçalves, and Miguel Xavier

Subjects
gut‐on‐chip, in vitro models, inflammatory bowel disease, intestinal inflammation, organoids, transwells, Science
Abstract

Abstract Inflammatory bowel disease causes a major burden to patients and healthcare systems, raising the need to develop effective therapies. Technological advances in cell culture, allied with ethical issues, have propelled in vitro models as essential tools to study disease aetiology, its progression, and possible therapies. Several cell‐based in vitro models of intestinal inflammation have been used, varying in their complexity and methodology to induce inflammation. Immortalized cell lines are extensively used due to their long‐term survival, in contrast to primary cultures that are short‐lived but patient‐specific. Recently, organoids and organ‐chips have demonstrated great potential by being physiologically more relevant. This review aims to shed light on the intricate nature of intestinal inflammation and cover recent works that report cell‐based in vitro models of human intestinal inflammation, encompassing diverse approaches and outcomes.

Published
2023
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4. Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering

Author

William R. Birmingham, Asbjørn Toftgaard Pedersen, Mafalda Dias Gomes, Mathias Bøje Madsen, Michael Breuer, John M. Woodley, and Nicholas J. Turner

Subjects
Science
Abstract

5-Hydroxymethylfurfural (HMF) can be transformed to a range of industrially useful derivatives, such as 2,5-diformylfuran (DFF), but the reactions needed for efficient industrial production are hindered by several issues. Here, the authors perform reaction and enzyme engineering resulting in a galactose oxidase variant with high activity towards HMF, improved oxygen binding and high productivity.

Published
2021
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5. Inflation as an information bottleneck: a strategy for identifying universality classes and making robust predictions

Author

Mafalda Dias, Jonathan Frazer, and Alexander Westphal

Subjects
Cosmology of Theories beyond the SM, Flux compactifications, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract In this work we propose a statistical approach to handling sources of theoretical uncertainty in string theory models of inflation. By viewing a model of inflation as a probabilistic graph, we show that there is an inevitable information bottleneck between the ultraviolet input of the theory and observables, as a simple consequence of the data processing theorem. This information bottleneck can result in strong hierarchies in the sensitivity of observables to the parameters of the underlying model and hence universal predictions with respect to at least some microphysical considerations. We also find other intriguing behaviour, such as sharp transitions in the predictions when certain hyperparameters cross a critical value. We develop a robust numerical approach to studying these behaviours by adapting methods often seen in the context of machine learning. We first test our approach by applying it to well known examples of universality, sharp transitions, and concentration phenomena in random matrix theory. We then apply the method to inflation with axion monodromy. We find universality with respect to a number of model parameters and that consistency with observational constraints implies that with very high probability certain perturbative corrections are non-negligible.

Published
2019
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6. Pole N-flation

Author

Mafalda Dias, Jonathan Frazer, Ander Retolaza, Marco Scalisi, and Alexander Westphal

Subjects
Cosmology of Theories beyond the SM, Supergravity Models, Supersymmetric Effective Theories, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract A second order pole in the scalar kinetic term can lead to a class of inflation models with universal predictions referred to as pole inflation or α-attractors. While this kinetic structure is ubiquitous in supergravity effective field theories, realising a consistent UV complete model in e.g. string theory is a non-trivial task. For one, one expects quantum corrections arising in the vicinity of the pole which may spoil the typical attractor dynamics. As a conservative estimate of the range of validity of supergravity models of pole inflation we employ the weak gravity conjecture (WGC). We find that this constrains the accessible part of the inflationary plateau by limiting the decay constant of the axion partner. For the original single complex field models, the WGC does not even allow the inflaton to reach the inflationary plateau region. We analyze if evoking the assistance of N scalar fields from the open string moduli helps addressing these problems. Pole N-flation could improve radiative control by reducing the required range of each individual field. However, the WGC bound prohibiting pole inflation for a single such field persists even for a collective motion of N such scalars if we impose the sublattice WGC. Finally, we outline steps towards an embedding of pole N-flation in type IIB string theory on fibred Calabi-Yau manifolds.

Published
2019
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7. Considerations when Measuring Biocatalyst Performance

Author

Mafalda Dias Gomes and John M. Woodley

Subjects
biocatalysis, immobilized enzymes, turnover number, process performance metrics, enzyme kinetics, enzyme stability, Organic chemistry, QD241-441
Abstract

As biocatalysis matures, it becomes increasingly important to establish methods with which to measure biocatalyst performance. Such measurements are important to assess immobilization strategies, different operating modes, and reactor configurations, aside from comparing protein engineered variants and benchmarking against economic targets. While conventional measurement techniques focus on a single performance metric (such as the total turnover number), here, it is argued that three metrics (achievable product concentration, productivity, and enzyme stability) are required for an accurate assessment of scalability.

Published
2019
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8. Contextual factors related to vector-control interventions for malaria: a scoping review and evidence and gap map protocol [version 1; peer review: awaiting peer review]

Author

Timothy Hugh Barker, Grace McKenzie McBride, Mafalda Dias, Raju Kanukula, Sabira Hasanoff, Danielle Pollock, Carrie Price, Alinune Nathanael Kabaghe, Ellie A. Akl, Jan Kolaczinki, and Zachary Munn

Subjects
Study Protocol, Articles, Malaria, vector-control, acceptability, feasibility, valuation of outcomes, contextual factors
Abstract

Objective This scoping review will identify existing literature regarding contextual factors relevant to vector-control interventions to prevent malaria. We will use the findings of the scoping review to produce an interactive evidence and gap map. The map will assist in the priority setting, development, and conduct of targeted systematic reviews. These systematic reviews seek to assist the Vector Control and Insecticide Resistance Unit of the World Health Organization’s Global Malaria Programme by informing recommendation development by their Guidelines Development Group. Introduction Malaria contributes substantially to the global burden of disease, with an estimated 247 million cases and 619,000 deaths in 2021. Vector-control is key in reducing malaria transmission. Vector-control interventions directly target the mosquito, reducing the potential for parasite infections. These interventions commonly include insecticides used in indoor residual spraying or insecticide-treated nets and larval source management. Several new vector-control interventions are under evaluation to complement these. In addition to estimating the effects of interventions on health outcomes, it is critical to understand how populations at risk of malaria consider them in terms of their feasibility, acceptability, and values. Inclusion Criteria Eligible studies will have assessed the contextual factors of feasibility or acceptability of the interventions of interest, or the valuation of the outcomes of interests. These assessments will be from the perspective of people who receive (residents) or deliver (workers or technicians) the vector-control intervention for the purpose of preventing malaria. Methods We will conduct this scoping review in accordance with the JBI methodology for scoping reviews and report in line with the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews (PRISMA-ScR). We will construct the evidence and gap map following guidance from the Campbell Collaboration.

Published
2024
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12. A Relação Escola-Família: que implicações no Sucesso Educativo e na Formação para a Cidadania?

Author

Botelho, Mafalda Dias, Diogo, Ana Isabel dos Santos Matias, and Fonseca, Josélia Mafalda Ribeiro

Subjects
Cidadania, Sucesso Escolar, Relação Escola-Família, Educação Pré-Escolar, 1.º Ciclo do Ensino Básico, Ciências da Educação
Abstract

Dissertação de Mestrado, Educação Pré-Escolar e Ensino do 1.º Ciclo do Ensino Básico, 13 de março de 2023, Universidade dos Açores. O envolvimento parental na vida escolar das crianças é socialmente reconhecido como essencial e indispensável. Não obstante este ser um tema muito estudado e debatido no âmbito da Sociologia, continua a ser pertinente refletir sobre os vínculos entre escola e família, sob o ponto de vista da Educação. Neste sentido, este relatório incide essencialmente nos agentes escola e família, bem como na relevância das relações entre estas no que diz respeito ao sucesso educativo das crianças e/ou dos alunos e ainda à construção de cidadãos reflexivos, responsáveis e ativos na sociedade. Assim, o reconhecimento da importância da relação entre a escola e a família e a intenção de conceber estratégias e promover atividades que envolvessem as famílias no quotidiano escolar dos seus educandos foram os principais motivos que levaram à opção pelo tema deste Relatório de Estágio: A Relação Escola-Família: que implicações no Sucesso Educativo e na formação para a Cidadania? Ao longo deste trabalho, é apresentada a prática educativa desenvolvida nos contextos de Estágio Pedagógico I e II, nos quais foram implementadas atividades potenciadoras da promoção de uma relação mais estreita entre a escola e as famílias. Ainda com o objetivo de obter representações da educadora de infância e da professora do 1.º Ciclo do Ensino Básico, bem como dos pais/encarregados de educação acerca da importância da relação entre a escola e a família, foram realizadas entrevistas às profissionais de educação e aos pais/encarregados de educação e foram aplicados inquéritos por questionário aos pais/encarregados de educação. Os dados obtidos possibilitaram planificar a ação educativa de forma contextualizada, potenciando o envolvimento e a participação das famílias. Concluímos, assim, com base na revisão da literatura e nas práticas implementadas, que é possível promover uma relação estreita entre a família e a escola, sendo as crianças e/ou os alunos os que mais beneficiam com ela. Contudo, apesar de reconhecida a importância deste vínculo, teimam em existir alguns entraves a ser superados nas dinâmicas desta relação. Torna-se, então, imprescindível continuar a diligenciar formas de ultrapassar esses obstáculos no sentido de um bem maior: potenciar o sucesso educativo das crianças e/ou dos alunos, bem como a formação dos mesmo enquanto cidadãos. ABSTRACT: The parental involvement in the school life of the childrens is socially recognized as essential and indispensable. Despite this being a topic much studied and debated within the scope of Sociology, it is still important to think about the bond between school and family on the point of education. This investigation focus essentially in the family and school agents as well as the importance between these two institutions for the education and formation of the students not only regarding the educational success of these but also helps building a citizens reflexive responsible and active in the environment surrounding them. In recognition of this importance for the relationship between school and family and the intention to devise strategies and promote activities that effectively involve families in school daily life and their students. These were the main reasons that led to the choice of the theme of this Report of Internship: The School-Family Relationship: What implications for Educational Success and training for Citizenship? Throughout this work, the educational practice developed in the contexts of Pedagogical Internship I and II is presented, in which activities and dynamics were implemented to promote a closer relationship between school and families. For this, and with the main objective of obtaining the conceptions and representations of both the kindergarten teacher and the teacher of the 1st Cycle of Basic Education, as well as the parents/guardians themselves about the importance of the relationship between school and family, interviews were carried out with education professionals, as well as with parents/guardians and questionnaire surveys were also applied to parents/guardians. The data that was obtained allowed a plan for the educational action in a contextualized way, enhancing the involvement and participation of families. We conclude, based on the literature review and practices implemented, that it is possible to promote a close relationship between the family and the school, as well as the children/students who will benefit most from these relationships being so connected and intertwined. Despite the importance and benefits of this bond being recognized, there are still some obstacles to be overcome in the dynamics of this relationship. It is essential to continue to work on ways to overcome these obstacles towards a greater good: to enhance the educational success of children/students, as well as their formation as citizens.

Published
2023

14. From mouth to gut: microfluidic in vitro simulation of human gastro-intestinal digestion and intestinal permeability

Author

Catarina Gonçalves, Miguel Xavier, Patrícia Rodrigues, Mafalda Dias Neto, Maria Inês Guedes, Victor Calero, and Lorenzo Pastrana

Subjects
Electrochemistry, Environmental Chemistry, Biochemistry, Spectroscopy, Analytical Chemistry
Abstract

Reproducible in vitro studies of bioaccessibility, intestinal absorption and bioavailability are key to the successful development of novel food ingredients or drugs aiming for oral administration. There is currently a...

Published
2023

15. Disease variant prediction with deep generative models of evolutionary data

Author

Yarin Gal, Jonathan Frazer, Kelly P Brock, Debora S. Marks, Mafalda Dias, Pascal Notin, Aidan N. Gomez, and Joseph K. Min

Subjects
Disease gene, Variable (computer science), Computational model, Multidisciplinary, Interpretation (logic), Computer science, Genetic variation, Computational biology, Disease, Sequence variation, Generative grammar
Abstract

Quantifying the pathogenicity of protein variants in human disease-related genes would have a marked effect on clinical decisions, yet the overwhelming majority (over 98%) of these variants still have unknown consequences1–3. In principle, computational methods could support the large-scale interpretation of genetic variants. However, state-of-the-art methods4–10 have relied on training machine learning models on known disease labels. As these labels are sparse, biased and of variable quality, the resulting models have been considered insufficiently reliable11. Here we propose an approach that leverages deep generative models to predict variant pathogenicity without relying on labels. By modelling the distribution of sequence variation across organisms, we implicitly capture constraints on the protein sequences that maintain fitness. Our model EVE (evolutionary model of variant effect) not only outperforms computational approaches that rely on labelled data but also performs on par with, if not better than, predictions from high-throughput experiments, which are increasingly used as evidence for variant classification12–16. We predict the pathogenicity of more than 36 million variants across 3,219 disease genes and provide evidence for the classification of more than 256,000 variants of unknown significance. Our work suggests that models of evolutionary information can provide valuable independent evidence for variant interpretation that will be widely useful in research and clinical settings. A new computational method, EVE, classifies human genetic variants in disease genes using deep generative models trained solely on evolutionary sequences.

Published
2021

17. EDP managing a new electricity era: the birth of ocean winds - managing the regulatory and technological risks of offshore wind development

Author

Vieira, Susana Mafalda Dias Albuquerque Guedes, Oliveira, Vitorino Mello, Traça, Daniel, and Portas, Paulo

Subjects
Renewable energy, Partnerships, Risk management, Sustainability, International regulations, Energy finance, Energy sector, Offshore wind, Ciências Sociais::Economia e Gestão [Domínio/Área Científica]
Abstract

With EDP’s entrance into the renewable energy market solar and wind energy became pillars of the renewable energy strategy. Jumping directly from onshore to floating offshore, EDP displayed a strategic core of innovation and geographical expansion. This case details their start on floating offshore from Wind Float Atlantic, their first main partnership in the sector to their eventual joint venture with Engie on Ocean Winds with a focus on offshore wind. This thesis details the path EDP has taken while analyzing their actions, meanwhile the report portion analyzes risks and opportunities on the offshore market overall and for joint ventures.

Published
2022

18. MaveDB v2: a curated community database with over three million variant effects from multiplexed functional assays

Author

Alan F Rubin, Joseph K Min, Nathan J Rollins, Estelle Y Da, Daniel Esposito, Matthew Harrington, Jeremy Stone, Aisha Haley Bianchi, Mafalda Dias, Jonathan Frazer, Yunfan Fu, Molly Gallaher, Iris Li, Olivia Moscatelli, Jesslyn YL Ong, Joshua E Rollins, Matthew J Wakefield, Shenyi 'Sunny' Ye, Amy Tam, Abbye E McEwen, Lea M Starita, Vanessa L Bryant, Debora S Marks, and Douglas M Fowler

Subjects
Database, Regulatory sequence, Genomics, Biology, Dna variants, computer.software_genre, Data submission, Gene, computer
Abstract

A central problem in genomics is understanding the effect of individual DNA variants. Multiplexed Assays of Variant Effect (MAVEs) can help address this challenge by measuring all possible single nucleotide variant effects in a gene or regulatory sequence simultaneously. Here we describe MaveDB v2, which has become the database of record for MAVEs. MaveDB now contains a large fraction of published studies, comprising over two hundred datasets and three million variant effect measurements. We created tools and APIs to streamline data submission and access, transforming MaveDB into a hub for the analysis and dissemination of these impactful datasets.

Published
2021

19. Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering

Author

John M. Woodley, William R. Birmingham, Mathias Bøje Madsen, Mafalda Dias Gomes, Michael Breuer, Asbjørn Toftgaard Pedersen, and Nicholas J. Turner

Subjects
Science, General Physics and Astronomy, Protein Engineering, Galactose Oxidase, Catalysis, Article, General Biochemistry, Genetics and Molecular Biology, Catalytic Domain, 5-hydroxymethylfurfural, High activity, Furaldehyde, SDG 7 - Affordable and Clean Energy, Furans, Reaction conditions, Multidisciplinary, Chemistry, General Chemistry, Protein engineering, Combinatorial chemistry, Enzymes, Mutagenesis, Biocatalysis, Galactose oxidase, Oxidation-Reduction
Abstract

5-Hydroxymethylfurfural (HMF) has emerged as a crucial bio-based chemical building block in the drive towards developing materials from renewable resources, due to its direct preparation from sugars and its readily diversifiable scaffold. A key obstacle in transitioning to bio-based plastic production lies in meeting the necessary industrial production efficiency, particularly in the cost-effective conversion of HMF to valuable intermediates. Toward addressing the challenge of developing scalable technology for oxidizing crude HMF to more valuable chemicals, here we report coordinated reaction and enzyme engineering to provide a galactose oxidase (GOase) variant with remarkably high activity toward HMF, improved O2 binding and excellent productivity (>1,000,000 TTN). The biocatalyst and reaction conditions presented here for GOase catalysed selective oxidation of HMF to 2,5-diformylfuran offers a productive blueprint for further development, giving hope for the creation of a biocatalytic route to scalable production of furan-based chemical building blocks from sustainable feedstocks., 5-Hydroxymethylfurfural (HMF) can be transformed to a range of industrially useful derivatives, such as 2,5-diformylfuran (DFF), but the reactions needed for efficient industrial production are hindered by several issues. Here, the authors perform reaction and enzyme engineering resulting in a galactose oxidase variant with high activity towards HMF, improved oxygen binding and high productivity.

Published
2021

20. Identite, Mobilite Sociale et Economie: Quelle France Avons-Nous Aujourd’hui?

Author

Ana Margarida Silva, Ana Pereira, Diogo Teixeira, Juliana Ferreira, Karine Magalhães, Mafalda Dias, and Sónia Couto

Abstract

Cet article montre que la France est un pays de valeurs, qui respecte ses habitants fiers de leur nationalité, bien que ceux-ci revendiquent leurs droits. En commençant par la compréhension des concepts de nation, état et identité, nous considérons l’existence d’un peuple français qui respecte les valeurs défendues par l’Union Européenne. La mobilité sociale, la fragilisation du lien social, la crise d’emploi et la crise de travail se rassemblent pour favoriser la montée de l’extrême droite. Après Mai 68, nous assistons à des revendications des «gilets jaunes» et à des actes terroristes qui causent une grande instabilité dans toute la France.Avec ce travail, nous découvrons que la crise économique et sociale, les attaques terroristes et les « gilets jaunes » secouent le pays et que, malgré tout, les Français se rétablissent avec une sécurité croissante., E- Revista de Estudos Interculturais , N.º 8 (2020)

Published
2021
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21. Supernova neutrino burst detection with the deep underground neutrino experiment: DUNE Collaboration

Author

M. A. Hernandez Morquecho, Jonas Rademacker, P. De Lurgio, C. A. Ternes, E. T. Worcester, H. Schellman, G. P. Zeller, C. J. Solano Salinas, Mingshui Chen, Andrew White, S. Berkman, André Rubbia, C. Barnes, Joshua Barrow, B. Bhuyan, O. V. Mineev, M. Bishai, Sandip Pakvasa, M. Chalifour, N. Poonthottathil, H. Berns, A. S. Hesam, S. H. Kettell, John Marshall, G. Sirri, Evgueni Goudzovski, M. A. Arroyave, J. Hugon, M. Kirby, D. Brailsford, Laura Paulucci, A. Hourlier, E. Hazen, L. Pasqualini, Christian Farnese, Armin Karcher, D. Smargianaki, Christopher L. Marshall, M. Karolak, H. Mendez, Y.-J. Jwa, Y. Karyotakis, Artur M. Ankowski, B. Morgan, L. Patrizii, Stefan Antusch, Paola Sala, N. Moggi, Claire Shepherd-Themistocleous, G. Mandrioli, M. R. While, A. M. Gago, R. Diurba, J. Berger, Alessandro Menegolli, B. Carlus, D. Boyden, T. Le, G. Christodoulou, L. Hertel, J. S. Díaz, B. Ramson, R. Gandrajula, Akitaka Ariga, Marvin L Marshak, R. Zaki, Ina Sarcevic, Eric W. Hoppe, Manuel Alejandro Segura Delgado, Kam-Biu Luk, M. Tzanov, K. Qi, J. A. B. Coelho, C. Vignoli, C. E. Lane, Giuseppe Benedetto Cerati, N. Bostan, David Delepine, Dave M Newbold, F. Krennrich, C. Mauger, J. Yu, D. Edmunds, P. Novella, K. Zeug, Z. Parsa, L. O. Arnold, Janice L. Thompson, F. Kamiya, K. Kothekar, S. Calvez, A. Chiriacescu, T. Rehak, M. V. Diwan, V. Savinov, P. Melas, T. Safford, E. Tatar, Hui Wang, V. Bellini, C. Alt, B. Abi, W. Flanagan, V. Papadimitriou, G. Zhu, S. Centro, J. J. Russell, W. C. Griffith, H. R. Gallagher, M. A. Uchida, N. Martinez, L. Greenler, Bo Yu, A. V. Waldron, D. J. Payne, C. Gotti, T. Miedema, S. Magill, Deywis Moreno, Utku Kose, Julián Félix, D. MacFarland, K. Gollwitzer, F. Varanini, S. Henry, K. Grzelak, B. Guo, Frank Filthaut, J. Reichenbacher, F. Muheim, Ralf Lehnert, T. A. Bolton, J. Greer, Y. T. Tsai, L. Camilleri, S. Nagu, J. A. Maloney, Z. Vallari, F. Bay, H.E. Rogers, Andrea Dell'Acqua, Y. Cui, P. A. Rodrigues, C. Wret, J. Zuklin, Paul Keener, D. A. Harris, Andrea Zani, Mario Campanelli, M. Newcomer, H. W. Sobel, C. Distefano, Ornella Palamara, M. A. Ramirez Delgado, J. D. Eisch, Riccardo Papaleo, D. Cherdack, Paolo Carniti, Leigh H. Whitehead, Karol Hennessy, S. Söldner-Rembold, P. Fernandez Menendez, J. Han, C. Y. Chi, M. Groh, Jeremy Wolcott, R. LaZur, Yu. Onishchuk, T. Hamernik, L. Pickering, John Evans, A. Weinstein, A. Sitraka, L. Bagby, S. J. Brice, Nicolas Lurkin, E. Raguzin, L. C. J. Rice, H. Carranza, Milos Lokajicek, K. Nishimura, H. S. Budd, C. S. Lin, A. A. Machado, Kevin J. Kelly, D. Sgalaberna, J. M. LoSecco, R. Petti, Y. Xiao, Ionel Lazanu, E. Zhivun, C. McGrew, Marzio Nessi, Chia-Chan Chang, M. Nebot-Guinot, C. Grant, Jaroslaw Pasternak, Z. Djurcic, W. Gu, D. Duchesneau, N. Kazaryan, Kendall Mahn, Jorge Molina, M. Oberling, H. O. Back, S. Sacerdoti, J. Sensenig, C. Montanari, E. Conley, B. Howard, D. M. DeMuth, A. Chatterjee, S. Kohn, F. Drielsma, J. L. Bazo Alba, Jane Nachtman, Y. A. 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H., Whittington, D., Wilking, M. J., Wilkinson, C., Williams, Z., Wilson, F., Wilson, R. J., Wolcott, J., Wongjirad, T., Wood, K., Wood, L., Worcester, E., Worcester, M., Wret, C., Wu, W., Xiao, Y., Yang, G., Yang, T., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, J., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G. P., Zennamo, J., Zeug, K., Zhang, C., Zhao, M., Zhivun, E., Zhu, G., Zimmerman, E. D., Zito, M., Zucchelli, S., Zuklin, J., Zutshi, V., Zwaska, R., Abi, B, Acciarri, R, Acero, M, Adamov, G, Adams, D, Adinolfi, M, Ahmad, Z, Ahmed, J, Alion, T, Alonso Monsalve, S, Alt, C, Anderson, J, Andreopoulos, C, Andrews, M, Andrianala, F, Andringa, S, Ankowski, A, Antonova, M, Antusch, S, Aranda-Fernandez, A, Ariga, A, Arnold, L, Arroyave, M, Asaadi, J, Aurisano, A, Aushev, V, Autiero, D, Azfar, F, Back, H, Back, J, Backhouse, C, Baesso, P, Bagby, L, Bajou, R, Balasubramanian, S, Baldi, P, Bambah, B, Barao, F, Barenboim, G, Barker, G, Barkhouse, W, Barnes, C, Barr, G, Barranco Monarca, J, Barros, N, Barrow, J, Bashyal, A, Basque, V, Bay, F, Alba, J, Beacom, J, Bechetoille, E, Behera, B, Bellantoni, L, Bellettini, G, Bellini, V, Beltramello, O, Belver, D, Benekos, N, Bento Neves, F, Berger, J, Berkman, S, Bernardini, P, Berner, R, Berns, H, Bertolucci, S, Betancourt, M, Bezawada, Y, Bhattacharjee, M, Bhuyan, B, Biagi, S, Bian, J, Biassoni, M, Biery, K, Bilki, B, Bishai, M, 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Vilela, C, Viren, B, Vrba, T, Wachala, T, Waldron, A, Wallbank, M, Wang, H, Wang, J, Wang, Y, Warburton, K, Warner, D, Wascko, M, Waters, D, Watson, A, Weatherly, P, Weber, A, Weber, M, Wei, H, Weinstein, A, Wenman, D, Wetstein, M, While, M, White, A, Whitehead, L, Whittington, D, Wilking, M, Wilkinson, C, Williams, Z, Wilson, F, Wilson, R, Wolcott, J, Wongjirad, T, Wood, K, Wood, L, Worcester, E, Worcester, M, Wret, C, Wu, W, Xiao, Y, Yang, G, Yang, T, Yershov, N, Yonehara, K, Young, T, Yu, B, Yu, J, Zaki, R, Zalesak, J, Zambelli, L, Zamorano, B, Zani, A, Zazueta, L, Zeller, G, Zennamo, J, Zeug, K, Zhang, C, Zhao, M, Zhivun, E, Zhu, G, Zimmerman, E, Zito, M, Zucchelli, S, Zuklin, J, Zutshi, V, and Zwaska, R

Subjects
Physics and Astronomy (miscellaneous), Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics, Computer Science::Digital Libraries, 01 natural sciences, Physics::Geophysics, Neutrino experiment, 0103 physical sciences, Deep Underground Neutrino Experiment, 010303 astronomy & astrophysics, Engineering (miscellaneous), Supernova, Neutrino, Physics, Time projection chamber, Neutrino, LAr TPC, Accretion (meteorology), 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Galaxy, Supernova, Neutrino detector, Computer Science::Mathematical Software, Liquid argon, High Energy Physics::Experiment, Neutrino
Abstract

This document was prepared by the DUNE collaboration using the resources of the Fermi National Accelerator Laboratory (Fermilab), a U.S. Department of Energy, Office of Science, HEP User Facility. Fermilab is managed by Fermi Research Alliance, LLC (FRA), acting under Contract No. DE-AC02-07CH11359. This work was supported by CNPq, FAPERJ, FAPEG and FAPESP, Brazil; CFI, IPP and NSERC, Canada;CERN;MŠMT,Czech Republic; ERDF, H2020-EU and MSCA, European Union; CNRS/IN2P3 and CEA, France; INFN, Italy; FCT, Portugal; NRF, South Korea; CAM, Fundación “La Caixa” and MICINN, Spain; SERI and SNSF, Switzerland; TÜB˙ITAK, Turkey; The Royal Society and UKRI/STFC, United Kingdom; DOE and NSF, United States of America. This research used resources of the National Energy Research Scientific Computing Center (NERSC), a U.S. Department of Energy Office of Science User Facility operated under Contract No. DE-AC02-05CH11231., Data Availability Statement This manuscript has no associated data or the data will not be deposited. [Authors’ comment: This manuscript describes sensitivity studies for the DUNE experiment using simulation only, and as such there are no experimental data to report.], The deep underground neutrino experiment (DUNE), a 40-kton underground liquid argon time projection chamber experiment, will be sensitive to the electron-neutrino flavor component of the burst of neutrinos expected from the next Galactic core-collapse supernova. Such an observation will bring unique insight into the astrophysics of core collapse as well as into the properties of neutrinos. The general capabilities of DUNE for neutrino detection in the relevant few- to few-tens-of-MeV neutrino energy range will be described. As an example, DUNE’s ability to constrain the νe spectral parameters of the neutrino burst will be considered., Commissariat à l'Énergie Atomique et aux Énergies Alternatives CEA, Fundação de Amparo à Pesquisa do Estado de São Paulo FAPESP, U.S. Department of Energy DE-AC02-05CH11231 USDOE, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro FAPERJ, Ministerstvo Školství, Mládeže a Tělovýchovy MŠMT, Fundação para a Ciência e a Tecnologia FCT, Royal Society, Ministerio de Ciencia e Innovación MICINN, Natural Sciences and Engineering Research Council of Canada NSERC, UK Research and Innovation UKRI, Instituto Nazionale di Fisica Nucleare INFN, Centre National de la Recherche Scientifique CNRS, Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq, National Research Foundation of Korea NRF, Institut National de Physique Nucléaire et de Physique des Particules IN2P3, H2020-EU, European Commission EC, European Regional Development Fund ERDF, TÜBİTAK, CERN, U.S. Department of Energy USDOE, Fundação de Amparo à Pesquisa do Estado de Goiás FAPEG, Multiple Sclerosis Center of Atlanta MSCA, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung SNF, Singapore Eye Research Institute SERI, Fermi Research Alliance, LLC DE-AC02-07CH11359, National Science Foundation NSF, Science and Technology Facilities Council STFC

Published
2021
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22. Large-scale clinical interpretation of genetic variants using evolutionary data and deep learning

Author

Yarin Gal, Aidan N. Gomez, Debora S. Marks, Pascal Notin, Jonathan Frazer, Mafalda Dias, and Kelly P Brock

Subjects
Disease gene, Interpretation (logic), business.industry, Computer science, Scale (chemistry), media_common.quotation_subject, Deep learning, Genetic variants, Contrast (statistics), Computational biology, Variable (computer science), Quality (business), Artificial intelligence, business, Gene, media_common
Abstract

Quantifying the pathogenicity of protein variants in human disease-related genes would have a profound impact on clinical decisions, yet the overwhelming majority (over 98%) of these variants still have unknown consequences1–3. In principle, computational methods could support the large-scale interpretation of genetic variants. However, prior methods4–7 have relied on training machine learning models on available clinical labels. Since these labels are sparse, biased, and of variable quality, the resulting models have been considered insufficiently reliable8. By contrast, our approach leverages deep generative models to predict the clinical significance of protein variants without relying on labels. The natural distribution of protein sequences we observe across organisms is the result of billions of evolutionary experiments9,10. By modeling that distribution, we implicitly capture constraints on the protein sequences that maintain fitness. Our model EVE (Evolutionary model of Variant Effect) not only outperforms computational approaches that rely on labelled data, but also performs on par, if not better than, high-throughput assays which are increasingly used as strong evidence for variant classification11–23. After thorough validation on clinical labels, we predict the pathogenicity of 11 million variants across 1,081 disease genes, and assign high-confidence reclassification for 72k Variants of Unknown Significance8. Our work suggests that models of evolutionary information can provide a strong source of independent evidence for variant interpretation and that the approach will be widely useful in research and clinical settings.

Published
2020

23. Neutrino interaction classification with a convolutional neural network in the DUNE far detector

Author

R.A. Rameika, J. Perry, M. Kirby, E. Zhivun, K. Zeug, R. LaZur, Marzio Nessi, D. Lorca, R. M. Berner, Sandip Pakvasa, J. J. De Vries, S. Shafaq, Jonas Rademacker, G. P. Zeller, R. Guenette, A. Hourlier, A. McNab, G. Vasseur, C. Petta, C. Grant, A. Olivares Del Campo, Joshua R. Klein, Vasundhara Singh, D. M. DeMuth, A. Chatterjee, P. Debbins, Paola Sala, G. Mandrioli, John G. Learned, S. Kohn, F. Drielsma, Joshua Barrow, John Marshall, Janice L. Thompson, F. Kamiya, E. Motuk, E. Gamberini, B. J. P. Jones, L. Di Giulio, J. Martin-Albo, E. Bechetoille, Gustaaf Brooijmans, K. Moffat, L.S. Rochester, T. L. Usher, R. Staley, Bo Yu, A. V. Waldron, Gabriella Carini, M. Dabrowski, Francesco Gonnella, C. Vilela, B. Zamorano, Warner A. Miller, Wladyslaw Henryk Trzaska, A. M. Gago, R. Diurba, N. Bostan, J. Spitz, M. Pozzato, Y. Cui, P. A. Rodrigues, J. D. Eisch, F. Cavanna, Sofia Vallecorsa, K. E. Duffy, Danny Marfatia, E. Segreto, Xin Qian, T. A. Mohayai, C. J. Solano Salinas, David Delepine, M. Gold, A. Borkum, N. McConkey, Stephen P. Gent, Andrew Smith, M. Manrique Plata, G. Christodoulou, S. Calvez, Juraj Bracinik, Sukalyan Chattopadhyay, Laura Dominé, A. Scarff, R. Northrop, R. Van Berg, B. Paulos, E. McCluskey, T. Patzak, G. Brunetti, J. Moon, P. E. L. Clarke, C. Palomares, A. Weinstein, A. Muir, E. Ewart, N. Gallice, Wei Wu, S. Gollapinni, M. Spanu, Xiaolu Ji, J. Chaves, G. Sirri, Evgueni Goudzovski, H. Mendez, Y.-J. Jwa, Hui Wang, V. Bellini, C. Alt, B. Abi, C. Wilkinson, M. Greenwood, Julián Félix, D. MacFarland, K. Gollwitzer, A. M. Szelc, Gareth J. Barker, F. Bay, H.E. Rogers, G. Zhu, S. Centro, S. Henry, M. B. Smy, J. Migenda, A. Sitraka, L. Bagby, J. M. LoSecco, F. Varanini, J. Stock, G. Yang, I. Kreslo, V. A. Kudryavtsev, M. A. Hernandez Morquecho, J. Bian, Yasaman Farzan, A. de Gouvea, Jürgen Pozimski, Andrea Dell'Acqua, A. Higuera, Yu. Onishchuk, T. Hamernik, Z. Tsamalaidze, Diana Navas-Nicolas, S. Jiménez, R. Zwaska, C. A. Ternes, Andrea Zani, T. Miedema, J. Fried, Paul Keener, Leigh H. Whitehead, N. Simos, R. B. Patterson, J. G. Boissevain, A. Laundrie, Mafalda Dias, I. Kadenko, L. Da Silva Peres, A. Karcher, A. Verdugo, R. Raboanary, P. Schlabach, C. Lastoria, D. Naples, Kazuhiro Terao, A. Paudel, L. V. Gomez Bermeo, H. O. Back, Andrew White, W. Metcalf, M. J. Dolinski, Yu. Kudenko, D. Gratieri, J. R. T. de Mello Neto, Raj Gandhi, F. Andrianala, F. Tortorici, Konstantinos Manolopoulos, L. Corwin, A. Lister, A. Delbart, A. Christensen, Chia-Chan Chang, Y. Penichot, M. Masud, S. Berkman, S. Magill, André Rubbia, C. Barnes, A. S. Hesam, D. Waters, D. Ruterbories, S. H. Kettell, M. Bongrand, J. Smolik, A. Bitadze, Yichen Li, L. Molina Bueno, G. Prior, M. Bonesini, K. Francis, J. Fowler, S. J. M. Peeters, Antonino Sergi, S. L. Mufson, M. Eads, R. Flight, R. Gran, Thorsten Lux, W. Ketchum, Karol Hennessy, S. Söldner-Rembold, C. S. Lin, T. Wongjirad, A. Gallego-Ros, Rakesh Kumar, N. Buchanan, S. Alonso Monsalve, Michael Mulhearn, N. J. C. Spooner, G. Ge, Alexander Tapper, S. B. Boyd, F. Muheim, P. Cotte, T. Hill, Ralf Lehnert, J.V. Dawson, S. Biagi, Christopher J. Milne, G. A. Valdiviesso, S. Sacerdoti, N. Solomey, Laura Manenti, A. Joglekar, K. Cho, E. Pantic, N. Moggi, M. Roda, A. Aranda-Fernandez, Kim Siyeon, X. Luo, A. Booth, Thomas Strauss, J. Calcutt, K. Warburton, M. Nalbandyan, Claire Shepherd-Themistocleous, James Stewart, N.V. Mokhov, H. Vieira de Souza, I. Lomidze, A. Radovic, S. Ravat, W. Mu, D. Autiero, Poonam Mehta, K. S. McFarland, C. T. Macias, N. Mauri, A. Lawrence, J. Urheim, S. Narita, J. Heise, R. Sipos, F. F. Wilson, Nektarios Benekos, Jianbei Liu, Renato Potenza, C. Cattadori, T. Stokes, Timothy M. Shaw, D. Braga, L. Li, F. Piastra, L. W. Koerner, C. Girerd, D. Montanari, Giorgio Riccobene, P. N. Ratoff, S. Di Domizio, T. Kutter, M. C. Goodman, D. C. Christian, J. Ahmed, M. Soderberg, G. Meng, A. C. Weber, Dario Gnani, E. Brianne, T. A. Bolton, J. Greer, Y. T. Tsai, L. Camilleri, S. Nagu, J. A. Maloney, Z. Vallari, J. Sensenig, G. Karagiorgi, A. Rappoldi, L. O. Arnold, V. Paolone, V. Pec, J. J. Russell, J. Pillow, S. Vergani, W. C. Griffith, H. R. Gallagher, M. H. Shaevitz, N. Barros, I. Caro Terrazas, R. Itay, L. Zazueta, Alexander Deisting, B. Rebel, M. Toups, Joleen Pater, Narendra Sahu, S. Gao, A. Marchionni, David H. Adams, M. E. Convery, F. Diaz, R. Hatcher, Marco Adinolfi, M. Chalifour, Haleh Khani Hadavand, B. Tapia Oregui, T. Yang, F. Marinho, M. Zhao, F. Cavalier, Chao Zhang, N. Nayak, M. V. Diwan, D. J. Payne, C. Gotti, R. Cross, T. Wachala, S. Gwon, Barry King, R. Mazza, Keith Rielage, J. Wang, Simon Lin, K. Wood, M. O. Wascko, B. Stillwell, A. Lambert, V. Basque, K. Mason, A. Holin, Randall P. Johnson, C. Castromonte, S. Li, D. Vanegas Forero, S. Emery, J. Marteau, D. A. Harris, H. da Motta, I. L. De Icaza Astiz, Giovanni Bellettini, C. Montanari, E. Conley, B. Howard, S. Fuess, D. A. Dwyer, E. Cristaldo, H. Razafinime, M. Biassoni, Alessandro Montanari, J. J. Evans, Paolo Calafiura, S. Prince, J. Haiston, Q. David, N. Dokania, E. D. Zimmerman, P. De Lurgio, R. Milincic, M. A. Leigui de Oliveira, A. Olivier, E. T. Worcester, T. J. Langford, L. Pickering, E. Hazen, D. Smargianaki, Christopher L. Marshall, Katsuya Yonehara, A. Sousa, A. L. Renshaw, S. Manly, P. Hamilton, S. Kasai, Mingshui Chen, K. Koehler, Christopher Brew, Pavel Snopok, Z. Ahmad, J. Maricic, Jason Kumar, D. Cherdack, Y. Rigaut, H. Carranza, Milos Lokajicek, A. P. Furmanski, P.T. Smith, George Adamov, Mario Campanelli, C. Distefano, Ornella Palamara, H. S. Budd, T. E. Coan, B. Radics, Olga Mena, K. Nishimura, C. Vignoli, Marc Weber, M. Kordosky, S. Andringa, K. Kothekar, Burak Bilki, W. Flanagan, L. Stanco, D. Brailsford, R. Howell, J. A. Musser, R. G. Van de Water, L. S. Gomez Fajardo, Jane Nachtman, S. Striganov, Srubabati Goswami, Z. Williams, Yi Chen, M. Hostert, Laura Paulucci, Y. A. Ramachers, D. A. Martinez Caicedo, R. M. de Almeida, Yasar Onel, A. M. Teklu, D. Mladenov, E. Blucher, S. Childress, C. Brizzolari, C. McGrew, V. Papadimitriou, J. Hoff, T. Miao, A. Stuart, P. Vahle, G. A. Horton-Smith, L. Pasqualini, C. Jesús-Valls, I. K. Furic, John Matthews, Aldo Penzo, Andrew Blake, A. Mislivec, L. Jiang, R. S. Fitzpatrick, G.L. Raselli, A. Scarpelli, A. C. Kaboth, T. Vrba, Piera Sapienza, M. Shamma, N. P. Samios, M. A. Arroyave, C. Andreopoulos, F. Terranova, D. Newhart, E. Raguzin, A. J. Roeth, R. Acciarri, L. C. J. Rice, Karol Lang, Simon Jones, S. Bolognesi, J. A. Nowak, B. Morgan, L. Patrizii, A. F. Moor, M. Potekhin, D. Duchesneau, N. Kazaryan, V. J. Guarino, R. Bajou, B. Carlus, D. Boyden, C. Cuesta, O. G. Miranda, C. Patrick, L. Rakotondravohitra, A. Izmaylov, Matthew Mewes, J. Trevor, José W. F. Valle, L. Montaño Zetina, M. Tenti, A. Rafique, Kendall Mahn, Jorge Molina, S. Tufanli, Ara Ioannisian, H. T. Rakotondramanana, X. Pons, Kam-Biu Luk, A. Caminata, K. Qi, Deywis Moreno, A. Heavey, M. Bhattacharjee, J. A. B. Coelho, J. K. Nelson, Grzegorz Deptuch, J. L. Bazo Alba, Amelia Maio, Giuseppe Benedetto Cerati, H. Duyang, H. Meyer, A. Schukraft, E. Kemp, T. Loew, R. J. Nichol, P. Ding, D. J. Summers, M. Worcester, L. Cremonesi, M. Sorel, F. Sergiampietri, Rex Tayloe, J. C. Freeman, Kaushik De, M. J. Rodriguez Alonso, J. Zuklin, I. Rakhno, J. R. Macier, Jeremy Wolcott, M. A. Acero, F. Barao, S. P. Kasetti, C. Mossey, R. Nandakumar, W. C. Louis, A. Surdo, K. Vaziri, Dave Sankey, K. Negishi, J. Asaadi, E. Valencia, F. Azfar, T. Lord, E. James, J. Nesbit, J. Bremer, Kate Scholberg, M. R. While, Pedro A. N. Machado, T. Alion, Gregory Iles, A. Friedland, Roberto Gutiérrez, Z. Ghorbani-Moghaddam, G. Lehmann Miotto, K. M. Heeger, C. S. Mishra, Vlastimil Kus, O. Gogota, A. Tonazzo, M. Karolak, J. Pinzino, H. Muramatsu, Z. Pavlovic, M. P. Andrews, M. Vermeulen, A. Guglielmi, J. Berger, Rukmani Mohanta, S. Murphy, C. Kuruppu, F. Bento Neves, S. Pordes, P. Weatherly, Andrew Norman, James John Brooke, M. Wallbank, Alessandro Menegolli, G. Testera, Janet Conrad, M. Newcomer, M. D. Messier, B. Szczerbinska, C. Backhouse, Stephen J. Parke, D. Franco, M. Soares Nunes, A. Maddalena, M. Antonova, T. Le, L. Hertel, T. Boschi, H. Y. Wei, Stephen Hillier, R. Gandrajula, Ina Sarcevic, Eric W. Hoppe, Manuel Alejandro Segura Delgado, V. A. Kostelecký, F. Ferraro, S. Green, Andrew Brandt, J. L. Raaf, J. Singh, H. Y. Liao, V. N. Solovov, K. Spurgeon, F. García-Carballeira, J. Freestone, D. Rivera, Alan Watson, K. Mavrokoridis, M. Tzanov, S. Santana, C. Mariani, M. J. Wilking, G. Barenboim, Carlos Escobar, J. Vasel, D. Redondo, S. R. Mishra, J. A. Gonzalez-Cuevas, R. K. Plunkett, R. A. Gomes, E. Gramellini, C. E. Lane, P. Bernardini, H. A. Tanaka, D. Gibin, M. Stancari, Ihn Sik Seong, B. Kirby, A. Bross, S. Menary, P. C. de Holanda, D. Warner, O. Dvornikov, C. E. Thorn, Filippo Resnati, L. Suter, L. Kashur, A. Scaramelli, C. M. Sutera, T. Kosc, K. K. Loo, O. V. Mineev, M. Bishai, K. Lande, H. Berns, R. J. Wilson, E. Smith, William J. Marciano, C. Bromberg, C. Hohl, L. M. Cremaldi, Matthew L Strait, P. Guzowski, R. Haenni, T. Young, F. Jediny, E. Granados, B. Behera, B. V. K. S. Potukuchi, P. Lasorak, Alastair Grant, Marco Verzocchi, Orlando L. G. Peres, J. S. Díaz, P. Novella, Y. Wang, Marcelo M. Guzzo, A. K. Giri, M. Torti, M. Tortola, B. Jargowsky, T. R. Junk, R. Dharmapalan, Shiroman Prakash, Seodong Shin, M. Santos-Maldonado, Cari L. Johnson, N. Poonthottathil, S. J. Patton, T. Schaffer, K. Grzelak, E. Church, C. Wret, Christian Farnese, Akitaka Ariga, Marvin L Marshak, G. S. Varner, M. Rai, A. Chiriacescu, T. Rehak, A. Papanestis, A. Aurisano, A. Norrick, N. Martinez, L. Greenler, B. Guo, Frank Filthaut, J. Reichenbacher, S. Ventura, Riccardo Papaleo, J. J. Back, D. Shooltz, Zelimir Djurcic, Alessandro Thea, P. Fernandez Menendez, J. Han, C. Y. Chi, M. Groh, Y. Bezawada, V. P. Luzio, F. Spagliardi, F. D. M. Blaszczyk, D. Pershey, Lina Necib, Enrique Fernandez-Martinez, J. S. Real, P. Baesso, H. Steiner, S. Lockwitz, G. Sinev, Massimo Rossella, S. Tariq, Gregory J Pawloski, T. Prakash, Arsen Khvedelidze, A.S. Dyshkant, M. Reggiani-Guzzo, M. Á. García-Peris, M. Kabirnezhad, Pierre Baldi, M. Mooney, E. Tyley, A. Hahn, M. P. Decowski, V. Galymov, E. Chardonnet, J. Franc, B. R. Littlejohn, B. Russell, M. Vagins, Jordan Ott, Niki Saoulidou, M. Oberling, E. Mazzucato, C. David, A. Mann, L. Fields, J. Sinclair, J. I. Crespo-Anadón, C. J. Densham, D. W. Schmitz, H. Schellman, Stefan Antusch, Z. Parsa, M. A. Uchida, H. W. Sobel, M. A. Ramirez Delgado, S. J. Brice, Nicolas Lurkin, A. A. Machado, R. Petti, Jaroslaw Pasternak, W. Gu, S. Bertolucci, A. Mazzacane, Patrick Dunne, M. C. Sanchez, A. N. Khotjantsev, N. Tsverava, F. Bonini, Marco Pallavicini, G. Savage, L. Wood, J. Soto-Oton, C. Sarasty, G. Pessina, O. Goodwin, K. K. Guthikonda, Y. Karyotakis, Artur M. Ankowski, D. Edmunds, T. Safford, E. Tatar, Utku Kose, D. Vargas, F. Pietropaolo, T. Hasegawa, J. Mills, Irina Mocioiu, C. N. Booth, L. Zambelli, S. Rescia, A. M. Iliescu, Andrés Castillo, Alex Reynolds, K. Biery, V. Aushev, D. A. Sanders, John F. Beacom, J. Zalesak, J. Barranco Monarca, Carl Grace, M. Muether, S. Roy, L. Pagani, Steven Gardiner, P. Madigan, J. Rodriguez Rondon, Alec Habig, A. Mastbaum, D. Douglas, Daniel Gastler, David Cussans, S. Matsuno, P. Green, B. Viren, J. Mousseau, Matthaeus Leitner, K. Fahey, Bindu A. Bambah, S. Dennis, P. P. Koller, D. Whittington, D. Garcia-Gamez, Sudarshan Paramesvaran, D. Belver, S. Zucchelli, S. Davini, R. L. Talaga, M. Wetstein, M. M. Khabibullin, D. Wenman, S. C. Timm, R. Sharma, R. Saakyan, B. Ramson, R. Zaki, Kenneth Long, V. Zutshi, Sandeep Miryala, Enrique Calvo, V. Radeka, H. S. Chen, C. Touramanis, J. M. Paley, Antonio Ereditato, N. Yershov, Alexandru Jipa, Olga Beltramello, J. T. Haigh, B. Gelli, Gregory J. Michna, F. Stocker, T. Gamble, J. J. Grudzinski, I. Gil-Botella, L. Simard, Wayne A. Barkhouse, A. Filkins, Daijin Kim, G.D. Barr, Junwei Huang, V. De Romeri, A. Cervera Villanueva, Robert Svoboda, A. Falcone, D. Caratelli, L. Bellantoni, A. Hackenburg, D. Caiulo, Sergey A. Kulagin, A. Bashyal, Beatriz B. Siffert, M. T. Graham, V. Susic, S. D. Reitzner, Dave M Newbold, C. K. Jung, F. Krennrich, C. Mauger, J. Yu, Paolo Carniti, Ionel Lazanu, M. Nebot-Guinot, R. Illingworth, G. Petrillo, A. Gendotti, A. Himmel, M. Rajaoalisoa, P. Bour, L. Mualem, E. Niner, S. Bordoni, James Mueller, W. Fox, Silvia Pascoli, K. Herner, Hem Raj Sharma, M. Betancourt, E. Pennacchio, F. W. Sippach, T. Li, E. Kearns, A. C. Ezeribe, S. Martynenko, Ph. Lebrun, D. Totani, Sandhya Choubey, A. Mefodiev, S. Balasubramanian, S. Rosauro-Alcaraz, B. Bhuyan, V. Savinov, P. Melas, Kevin J. Kelly, D. Sgalaberna, Y. Xiao, C. Rubbia, A. G. Cocco, C. Morris, A. Cervelli, D. Pugnere, C. A. Moura, M. Zito, A. D. Marino, G. C. Blazey, T. Durkin, L. Escudero Sanchez, J. Rout, P. de Jong, B. T. Fleming, R. Poling, J. Hartnell, Robert Shrock, J. Zennamo, A. De Roeck, M. Calin, M. Mellinato, Shu Li, Kristian Harder, J. Hewes, Sandro Palestini, M. Parvu, James A. Anderson, G. S. Davies, I. De Bonis, L. Di Noto, W. E. Sondheim, Nikolina Ilic, C. E. Tull, K. Soustruznik, M. Leyton, J. Hugon, K. V. Tsang, J. Maneira, Abi, B., Acciarri, R., Acero, M. A., Adamov, G., Adams, D., Adinolfi, M., Ahmad, Z., Ahmed, J., Alion, T., Alonso Monsalve, S., Alt, C., Anderson, J., Andreopoulos, C., Andrews, M. P., Andrianala, F., Andringa, S., Ankowski, A., Antonova, M., Antusch, S., Aranda-Fernandez, A., Ariga, A., Arnold, L. O., Arroyave, M. A., Asaadi, J., Aurisano, A., Aushev, V., Autiero, D., Azfar, F., Back, H., Back, J. J., Backhouse, C., Baesso, P., Bagby, L., Bajou, R., Balasubramanian, S., Baldi, P., Bambah, B., Barao, F., Barenboim, G., Barker, G. J., Barkhouse, W., Barnes, C., Barr, G., Barranco Monarca, J., Barros, N., Barrow, J. L., Bashyal, A., Basque, V., Bay, F., Bazo Alba, J. L., Beacom, J. F., Bechetoille, E., Behera, B., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Belver, D., Benekos, N., Bento Neves, F., Berger, J., Berkman, S., Bernardini, P., Berner, R. M., Berns, H., Bertolucci, S., Betancourt, M., Bezawada, Y., Bhattacharjee, M., Bhuyan, B., Biagi, S., Bian, J., Biassoni, M., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blanco Siffert, B., Blaszczyk, F. D. M., Blazey, G. C., Blucher, E., Boissevain, J., Bolognesi, S., Bolton, T., Bonesini, M., Bongrand, M., Bonini, F., Booth, A., Booth, C., Bordoni, S., Borkum, A., Boschi, T., Bostan, N., Bour, P., Boyd, S. B., Boyden, D., Bracinik, J., Braga, D., Brailsford, D., Brandt, A., Bremer, J., Brew, C., Brianne, E., Brice, S. J., Brizzolari, C., Bromberg, C., Brooijmans, G., Brooke, J., Bross, A., Brunetti, G., Buchanan, N., Budd, H., Caiulo, D., Calafiura, P., Calcutt, J., Calin, M., Calvez, S., Calvo, E., Camilleri, L., Caminata, A., Campanelli, M., Caratelli, D., Carini, G., Carlus, B., Carniti, P., Caro Terrazas, I., Carranza, H., Castillo, A., Castromonte, C., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cervelli, A., Cervera Villanueva, A., Chalifour, M., Chang, C., Chardonnet, E., Chatterjee, A., Chattopadhyay, S., Chaves, J., Chen, H., Chen, M., Chen, Y., Cherdack, D., Chi, C., Childress, S., Chiriacescu, A., Cho, K., Choubey, S., Christensen, A., Christian, D., Christodoulou, G., Church, E., Clarke, P., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Conley, E., Conrad, J. M., Convery, M., Corwin, L., Cotte, P., Cremaldi, L., Cremonesi, L., Crespo-Anadon, J. I., Cristaldo, E., Cross, R., Cuesta, C., Cui, Y., Cussans, D., Dabrowski, M., Da Motta, H., Da Silva Peres, L., David, C., David, Q., Davies, G. S., Davini, S., Dawson, J., De, K., De Almeida, R. M., Debbins, P., De Bonis, I., Decowski, M. P., De Gouvea, A., De Holanda, P. C., De Icaza Astiz, I. L., Deisting, A., De Jong, P., Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., De Lurgio, P., De Mello Neto, J. R. T., Demuth, D. M., Dennis, S., Densham, C., Deptuch, G., De Roeck, A., De Romeri, V., De Vries, J. J., Dharmapalan, R., Dias, M., Diaz, F., Diaz, J. S., Di Domizio, S., Di Giulio, L., Ding, P., Di Noto, L., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Dokania, N., Dolinski, M. J., Domine, L., Douglas, D., Drielsma, F., Duchesneau, D., Duffy, K., Dunne, P., Durkin, T., Duyang, H., Dvornikov, O., Dwyer, D. A., Dyshkant, A. S., Eads, M., Edmunds, D., Eisch, J., Emery, S., Ereditato, A., Escobar, C. O., Escudero Sanchez, L., Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Falcone, A., Farnese, C., Farzan, Y., Felix, J., Fernandez-Martinez, E., Fernandez Menendez, P., Ferraro, F., Fields, L., Filkins, A., Filthaut, F., Fitzpatrick, R. S., Flanagan, W., Fleming, B., Flight, R., Fowler, J., Fox, W., Franc, J., Francis, K., Franco, D., Freeman, J., Freestone, J., Fried, J., Friedland, A., Fuess, S., Furic, I., Furmanski, A. P., Gago, A., Gallagher, H., Gallego-Ros, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Gandhi, R., Gandrajula, R., Gao, S., Garcia-Carballeira, F., Garcia-Gamez, D., Garcia-Peris, M. A., Gardiner, S., Gastler, D., Ge, G., Gelli, B., Gendotti, A., Gent, S., Ghorbani-Moghaddam, Z., Gibin, D., Gil-Botella, I., Girerd, C., Giri, A. K., Gnani, D., Gogota, O., Gold, M., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Gomez Bermeo, L. V., Gomez Fajardo, L. S., Gonnella, F., Gonzalez-Cuevas, J. A., Goodman, M. C., Goodwin, O., Goswami, S., Gotti, C., Goudzovski, E., Grace, C., Graham, M., Gramellini, E., Gran, R., Granados, E., Grant, A., Grant, C., Gratieri, D., Green, P., Green, S., Greenler, L., Greenwood, M., Greer, J., Griffith, W. C., Groh, M., Grudzinski, J., Grzelak, K., Gu, W., Guarino, V., Guenette, R., Guglielmi, A., Guo, B., Guthikonda, K. K., Gutierrez, R., Guzowski, P., Guzzo, M. M., Gwon, S., Habig, A., Hackenburg, A., Hadavand, H., Haenni, R., Hahn, A., Haigh, J., Haiston, J., Hamernik, T., Hamilton, P., Han, J., Harder, K., Harris, D. A., Hartnell, J., Hasegawa, T., Hatcher, R., Hazen, E., Heavey, A., Heeger, K. M., Heise, J., Hennessy, K., Henry, S., Hernandez Morquecho, M. A., Herner, K., Hertel, L., Hesam, A. S., Hewes, J., Higuera, A., Hill, T., Hillier, S. J., Himmel, A., Hoff, J., Hohl, C., Holin, A., Hoppe, E., Horton-Smith, G. A., Hostert, M., Hourlier, A., Howard, B., Howell, R., Huang, J., Hugon, J., Iles, G., Ilic, N., Iliescu, A. M., Illingworth, R., Ioannisian, A., Itay, R., Izmaylov, A., James, E., Jargowsky, B., Jediny, F., Jesus-Valls, C., Ji, X., Jiang, L., Jimenez, S., Jipa, A., Joglekar, A., Johnson, C., Johnson, R., Jones, B., Jones, S., Jung, C. K., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A., Kadenko, I., Kamiya, F., Karagiorgi, G., Karcher, A., Karolak, M., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Kazaryan, N., Kearns, E., Keener, P., Kelly, K. J., Kemp, E., Ketchum, W., Kettell, S. H., Khabibullin, M., Khotjantsev, A., Khvedelidze, A., Kim, D., King, B., Kirby, B., Kirby, M., Klein, J., Koehler, K., Koerner, L. W., Kohn, S., Koller, P. P., Kordosky, M., Kosc, T., Kose, U., Kostelecky, V. A., Kothekar, K., Krennrich, F., Kreslo, I., Kudenko, Y., Kudryavtsev, V. A., Kulagin, S., Kumar, J., Kumar, R., Kuruppu, C., Kus, V., Kutter, T., Lambert, A., Lande, K., Lane, C. E., Lang, K., Langford, T., Lasorak, P., Last, D., Lastoria, C., Laundrie, A., Lawrence, A., Lazanu, I., Lazur, R., Le, T., Learned, J., Lebrun, P., Lehmann Miotto, G., Lehnert, R., Leigui De Oliveira, M. A., Leitner, M., Leyton, M., Li, L., Li, S., Li, S. W., Li, T., Li, Y., Liao, H., Lin, C. S., Lin, S., Lister, A., Littlejohn, B. R., Liu, J., Lockwitz, S., Loew, T., Lokajicek, M., Lomidze, I., Long, K., Loo, K., Lorca, D., Lord, T., Losecco, J. M., Louis, W. C., Luk, K. B., Luo, X., Lurkin, N., Lux, T., Luzio, V. P., Macfarland, D., Machado, A. A., Machado, P., Macias, C. T., Macier, J. R., Maddalena, A., Madigan, P., Magill, S., Mahn, K., Maio, A., Maloney, J. A., Mandrioli, G., Maneira, J., Manenti, L., Manly, S., Mann, A., Manolopoulos, K., Manrique Plata, M., Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marinho, F., Marino, A. D., Marshak, M., Marshall, C., Marshall, J., Marteau, J., Martin-Albo, J., Martinez, N., Martinez Caicedo, D. A., Martynenko, S., Mason, K., Mastbaum, A., Masud, M., Matsuno, S., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mazza, R., Mazzacane, A., Mazzucato, E., Mccluskey, E., Mcconkey, N., Mcfarland, K. S., Mcgrew, C., Mcnab, A., Mefodiev, A., Mehta, P., Melas, P., Mellinato, M., Mena, O., Menary, S., Mendez, H., Menegolli, A., Meng, G., Messier, M. D., Metcalf, W., Mewes, M., Meyer, H., Miao, T., Michna, G., Miedema, T., Migenda, J., Milincic, R., Miller, W., Mills, J., Milne, C., Mineev, O., Miranda, O. G., Miryala, S., Mishra, C. S., Mishra, S. R., Mislivec, A., Mladenov, D., Mocioiu, I., Moffat, K., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J., Molina Bueno, L., Montanari, A., Montanari, C., Montanari, D., Montano Zetina, L. M., Moon, J., Mooney, M., Moor, A., Moreno, D., Morgan, B., Morris, C., Mossey, C., Motuk, E., Moura, C. A., Mousseau, J., Mu, W., Mualem, L., Mueller, J., Muether, M., Mufson, S., Muheim, F., Muir, A., Mulhearn, M., Muramatsu, H., Murphy, S., Musser, J., Nachtman, J., Nagu, S., Nalbandyan, M., Nandakumar, R., Naples, D., Narita, S., Navas-Nicolas, D., Nayak, N., Nebot-Guinot, M., Necib, L., Negishi, K., Nelson, J. K., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Newhart, D., Nichol, R., Niner, E., Nishimura, K., Norman, A., Norrick, A., Northrop, R., Novella, P., Nowak, J. A., Oberling, M., Olivares Del Campo, A., Olivier, A., Onel, Y., Onishchuk, Y., Ott, J., Pagani, L., Pakvasa, S., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Pantic, E., Paolone, V., Papadimitriou, V., Papaleo, R., Papanestis, A., Paramesvaran, S., Parke, S., Parsa, Z., Parvu, M., Pascoli, S., Pasqualini, L., Pasternak, J., Pater, J., Patrick, C., Patrizii, L., Patterson, R. B., Patton, S. J., Patzak, T., Paudel, A., Paulos, B., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Peeters, S. J. M., Penichot, Y., Pennacchio, E., Penzo, A., Peres, O. L. G., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Piastra, F., Pickering, L., Pietropaolo, F., Pillow, J., Pinzino, J., Plunkett, R., Poling, R., Pons, X., Poonthottathil, N., Pordes, S., Potekhin, M., Potenza, R., Potukuchi, B. V. K. S., Pozimski, J., Pozzato, M., Prakash, S., Prakash, T., Prince, S., Prior, G., Pugnere, D., Qi, K., Qian, X., Raaf, J. L., Raboanary, R., Radeka, V., Rademacker, J., Radics, B., Radovic, A., Rafique, A., Raguzin, E., Rai, M., Rajaoalisoa, M., Rakhno, I., Rakotondramanana, H. T., Rakotondravohitra, L., Ramachers, Y. A., Rameika, R., Ramirez Delgado, M. A., Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Ravat, S., Razafinime, H., Real, J. S., Rebel, B., Redondo, D., Reggiani-Guzzo, M., Rehak, T., Reichenbacher, J., Reitzner, S. D., Renshaw, A., Rescia, S., Resnati, F., Reynolds, A., Riccobene, G., Rice, L. C. J., Rielage, K., Rigaut, Y., Rivera, D., Rochester, L., Roda, M., Rodrigues, P., Rodriguez Alonso, M. J., Rodriguez Rondon, J., Roeth, A. J., Rogers, H., Rosauro-Alcaraz, S., Rossella, M., Rout, J., Roy, S., Rubbia, A., Rubbia, C., Russell, B., Russell, J., Ruterbories, D., Saakyan, R., Sacerdoti, S., Safford, T., Sahu, N., Sala, P., Samios, N., Sanchez, M. C., Sanders, D. A., Sankey, D., Santana, S., Santos-Maldonado, M., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Savage, G., Savinov, V., Scaramelli, A., Scarff, A., Scarpelli, A., Schaffer, T., Schellman, H., Schlabach, P., Schmitz, D., Scholberg, K., Schukraft, A., Segreto, E., Sensenig, J., Seong, I., Sergi, A., Sergiampietri, F., Sgalaberna, D., Shaevitz, M. H., Shafaq, S., Shamma, M., Sharma, H. R., Sharma, R., Shaw, T., Shepherd-Themistocleous, C., Shin, S., Shooltz, D., Shrock, R., Simard, L., Simos, N., Sinclair, J., Sinev, G., Singh, J., Singh, V., Sipos, R., Sippach, F. W., Sirri, G., Sitraka, A., Siyeon, K., Smargianaki, D., Smith, A., Smith, E., Smith, P., Smolik, J., Smy, M., Snopok, P., Soares Nunes, M., Sobel, H., Soderberg, M., Solano Salinas, C. J., Soldner-Rembold, S., Solomey, N., Solovov, V., Sondheim, W. E., Sorel, M., Soto-Oton, J., Sousa, A., Soustruznik, K., Spagliardi, F., Spanu, M., Spitz, J., Spooner, N. J. C., Spurgeon, K., Staley, R., Stancari, M., Stanco, L., Steiner, H. M., Stewart, J., Stillwell, B., Stock, J., Stocker, F., Stokes, T., Strait, M., Strauss, T., Striganov, S., Stuart, A., Summers, D., Surdo, A., Susic, V., Suter, L., Sutera, C. M., Svoboda, R., Szczerbinska, B., Szelc, A. M., Talaga, R., Tanaka, H. A., Tapia Oregui, B., Tapper, A., Tariq, S., Tatar, E., Tayloe, R., Teklu, A. M., Tenti, M., Terao, K., Ternes, C. A., Terranova, F., Testera, G., Thea, A., Thompson, J. L., Thorn, C., Timm, S. C., Tonazzo, A., Torti, M., Tortola, M., Tortorici, F., Totani, D., Toups, M., Touramanis, C., Trevor, J., Trzaska, W. H., Tsai, Y. T., Tsamalaidze, Z., Tsang, K. V., Tsverava, N., Tufanli, S., Tull, C., Tyley, E., Tzanov, M., Uchida, M. A., Urheim, J., Usher, T., Vagins, M. R., Vahle, P., Valdiviesso, G. A., Valencia, E., Vallari, Z., Valle, J. W. F., Vallecorsa, S., Van Berg, R., Van De Water, R. G., Vanegas Forero, D., Varanini, F., Vargas, D., Varner, G., Vasel, J., Vasseur, G., Vaziri, K., Ventura, S., Verdugo, A., Vergani, S., Vermeulen, M. A., Verzocchi, M., Vieira De Souza, H., Vignoli, C., Vilela, C., Viren, B., Vrba, T., Wachala, T., Waldron, A. V., Wallbank, M., Wang, H., Wang, J., Wang, Y., Warburton, K., Warner, D., Wascko, M., Waters, D., Watson, A., Weatherly, P., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenman, D., Wetstein, M., While, M. R., White, A., Whitehead, L. H., Whittington, D., Wilking, M. J., Wilkinson, C., Williams, Z., Wilson, F., Wilson, R. J., Wolcott, J., Wongjirad, T., Wood, K., Wood, L., Worcester, E., Worcester, M., Wret, C., Wu, W., Xiao, Y., Yang, G., Yang, T., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, J., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G. P., Zennamo, J., Zeug, K., Zhang, C., Zhao, M., Zhivun, E., Zhu, G., Zimmerman, E. D., Zito, M., Zucchelli, S., Zuklin, J., Zutshi, V., Zwaska, R., Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), DUNE, XENON (IHEF, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), Abi, B, Acciarri, R, Acero, M, Adamov, G, Adams, D, Adinolfi, M, Ahmad, Z, Ahmed, J, Alion, T, Alonso Monsalve, S, Alt, C, Anderson, J, Andreopoulos, C, Andrews, M, Andrianala, F, Andringa, S, Ankowski, A, Antonova, M, Antusch, S, Aranda-Fernandez, A, Ariga, A, Arnold, L, Arroyave, M, Asaadi, J, Aurisano, A, Aushev, V, Autiero, D, Azfar, F, Back, H, Back, J, Backhouse, C, Baesso, P, Bagby, L, Bajou, R, Balasubramanian, S, Baldi, P, Bambah, B, Barao, F, Barenboim, G, Barker, G, Barkhouse, W, Barnes, C, Barr, G, Barranco Monarca, J, Barros, N, Barrow, J, Bashyal, A, Basque, V, Bay, F, Bazo Alba, J, Beacom, J, Bechetoille, E, Behera, B, Bellantoni, L, Bellettini, G, Bellini, V, Beltramello, O, Belver, D, Benekos, N, Bento Neves, F, Berger, J, Berkman, S, Bernardini, P, Berner, R, Berns, H, Bertolucci, S, Betancourt, M, Bezawada, Y, Bhattacharjee, M, Bhuyan, B, Biagi, S, Bian, J, Biassoni, M, Biery, K, Bilki, B, Bishai, M, Bitadze, A, Blake, A, Blanco Siffert, B, Blaszczyk, F, Blazey, G, Blucher, E, Boissevain, J, Bolognesi, S, Bolton, T, Bonesini, M, Bongrand, M, Bonini, F, Booth, A, Booth, C, Bordoni, S, Borkum, A, Boschi, T, Bostan, N, Bour, P, Boyd, S, Boyden, D, Bracinik, J, Braga, D, Brailsford, D, Brandt, A, Bremer, J, Brew, C, Brianne, E, Brice, S, Brizzolari, C, Bromberg, C, Brooijmans, G, Brooke, J, Bross, A, Brunetti, G, Buchanan, N, Budd, H, Caiulo, D, Calafiura, P, Calcutt, J, Calin, M, Calvez, S, Calvo, E, Camilleri, L, Caminata, A, Campanelli, M, Caratelli, D, Carini, G, Carlus, B, Carniti, P, Caro Terrazas, I, Carranza, H, Castillo, A, Castromonte, C, Cattadori, C, Cavalier, F, Cavanna, F, Centro, S, Cerati, G, Cervelli, A, Cervera Villanueva, A, Chalifour, M, Chang, C, Chardonnet, E, Chatterjee, A, Chattopadhyay, S, Chaves, J, Chen, H, Chen, M, Chen, Y, Cherdack, D, Chi, C, Childress, S, Chiriacescu, A, Cho, K, Choubey, S, Christensen, A, Christian, D, Christodoulou, G, Church, E, Clarke, P, Coan, T, Cocco, A, Coelho, J, Conley, E, Conrad, J, Convery, M, Corwin, L, Cotte, P, Cremaldi, L, Cremonesi, L, Crespo-Anadon, J, Cristaldo, E, Cross, R, Cuesta, C, Cui, Y, Cussans, D, Dabrowski, M, Da Motta, H, Da Silva Peres, L, David, C, David, Q, Davies, G, Davini, S, Dawson, J, De, K, De Almeida, R, Debbins, P, De Bonis, I, Decowski, M, De Gouvea, A, De Holanda, P, De Icaza Astiz, I, Deisting, A, De Jong, P, Delbart, A, Delepine, D, Delgado, M, Dell'Acqua, A, De Lurgio, P, De Mello Neto, J, Demuth, D, Dennis, S, Densham, C, Deptuch, G, De Roeck, A, De Romeri, V, De Vries, J, Dharmapalan, R, Dias, M, Diaz, F, Diaz, J, Di Domizio, S, Di Giulio, L, Ding, P, Di Noto, L, Distefano, C, Diurba, R, Diwan, M, Djurcic, Z, Dokania, N, Dolinski, M, Domine, L, Douglas, D, Drielsma, F, Duchesneau, D, Duffy, K, Dunne, P, Durkin, T, Duyang, H, Dvornikov, O, Dwyer, D, Dyshkant, A, Eads, M, Edmunds, D, Eisch, J, Emery, S, Ereditato, A, Escobar, C, Escudero Sanchez, L, Evans, J, Ewart, E, Ezeribe, A, Fahey, K, Falcone, A, Farnese, C, Farzan, Y, Felix, J, Fernandez-Martinez, E, Fernandez Menendez, P, Ferraro, F, Fields, L, Filkins, A, Filthaut, F, Fitzpatrick, R, Flanagan, W, Fleming, B, Flight, R, Fowler, J, Fox, W, Franc, J, Francis, K, Franco, D, Freeman, J, Freestone, J, Fried, J, Friedland, A, Fuess, S, Furic, I, Furmanski, A, Gago, A, Gallagher, H, Gallego-Ros, A, Gallice, N, Galymov, V, Gamberini, E, Gamble, T, Gandhi, R, Gandrajula, R, Gao, S, Garcia-Carballeira, F, Garcia-Gamez, D, Garcia-Peris, M, Gardiner, S, Gastler, D, Ge, G, Gelli, B, Gendotti, A, Gent, S, Ghorbani-Moghaddam, Z, Gibin, D, Gil-Botella, I, Girerd, C, Giri, A, Gnani, D, Gogota, O, Gold, M, Gollapinni, S, Gollwitzer, K, Gomes, R, Gomez Bermeo, L, Gomez Fajardo, L, Gonnella, F, Gonzalez-Cuevas, J, Goodman, M, Goodwin, O, Goswami, S, Gotti, C, Goudzovski, E, Grace, C, Graham, M, Gramellini, E, Gran, R, Granados, E, Grant, A, Grant, C, Gratieri, D, Green, P, Green, S, Greenler, L, Greenwood, M, Greer, J, Griffith, W, Groh, M, Grudzinski, J, Grzelak, K, Gu, W, Guarino, V, Guenette, R, Guglielmi, A, Guo, B, Guthikonda, K, Gutierrez, R, Guzowski, P, Guzzo, M, Gwon, S, Habig, A, Hackenburg, A, Hadavand, H, Haenni, R, Hahn, A, Haigh, J, Haiston, J, Hamernik, T, Hamilton, P, Han, J, Harder, K, Harris, D, Hartnell, J, Hasegawa, T, Hatcher, R, Hazen, E, Heavey, A, Heeger, K, Heise, J, Hennessy, K, Henry, S, Hernandez Morquecho, M, Herner, K, Hertel, L, Hesam, A, Hewes, J, Higuera, A, Hill, T, Hillier, S, Himmel, A, Hoff, J, Hohl, C, Holin, A, Hoppe, E, Horton-Smith, G, Hostert, M, Hourlier, A, Howard, B, Howell, R, Huang, J, Hugon, J, Iles, G, Ilic, N, Iliescu, A, Illingworth, R, Ioannisian, A, Itay, R, Izmaylov, A, James, E, Jargowsky, B, Jediny, F, Jesus-Valls, C, Ji, X, Jiang, L, Jimenez, S, Jipa, A, Joglekar, A, Johnson, C, Johnson, R, Jones, B, Jones, S, Jung, C, Junk, T, Jwa, Y, Kabirnezhad, M, Kaboth, A, Kadenko, I, Kamiya, F, Karagiorgi, G, Karcher, A, Karolak, M, Karyotakis, Y, Kasai, S, Kasetti, S, Kashur, L, Kazaryan, N, Kearns, E, Keener, P, Kelly, K, Kemp, E, Ketchum, W, Kettell, S, Khabibullin, M, Khotjantsev, A, Khvedelidze, A, Kim, D, King, B, Kirby, B, Kirby, M, Klein, J, Koehler, K, Koerner, L, Kohn, S, Koller, P, Kordosky, M, Kosc, T, Kose, U, Kostelecky, V, Kothekar, K, Krennrich, F, Kreslo, I, Kudenko, Y, Kudryavtsev, V, Kulagin, S, Kumar, J, Kumar, R, Kuruppu, C, Kus, V, Kutter, T, Lambert, A, Lande, K, Lane, C, Lang, K, Langford, T, Lasorak, P, Last, D, Lastoria, C, Laundrie, A, Lawrence, A, Lazanu, I, Lazur, R, Le, T, Learned, J, Lebrun, P, Lehmann Miotto, G, Lehnert, R, Leigui De Oliveira, M, Leitner, M, Leyton, M, Li, L, Li, S, Li, T, Li, Y, Liao, H, Lin, C, Lin, S, Lister, A, Littlejohn, B, Liu, J, Lockwitz, S, Loew, T, Lokajicek, M, Lomidze, I, Long, K, Loo, K, Lorca, D, Lord, T, Losecco, J, Louis, W, Luk, K, Luo, X, Lurkin, N, Lux, T, Luzio, V, Macfarland, D, Machado, A, Machado, P, Macias, C, Macier, J, Maddalena, A, Madigan, P, Magill, S, Mahn, K, Maio, A, Maloney, J, Mandrioli, G, Maneira, J, Manenti, L, Manly, S, Mann, A, Manolopoulos, K, Manrique Plata, M, Marchionni, A, Marciano, W, Marfatia, D, Mariani, C, Maricic, J, Marinho, F, Marino, A, Marshak, M, Marshall, C, Marshall, J, Marteau, J, Martin-Albo, J, Martinez, N, Martinez Caicedo, D, Martynenko, S, Mason, K, Mastbaum, A, Masud, M, Matsuno, S, Matthews, J, Mauger, C, Mauri, N, Mavrokoridis, K, Mazza, R, Mazzacane, A, Mazzucato, E, Mccluskey, E, Mcconkey, N, Mcfarland, K, Mcgrew, C, Mcnab, A, Mefodiev, A, Mehta, P, Melas, P, Mellinato, M, Mena, O, Menary, S, Mendez, H, Menegolli, A, Meng, G, Messier, M, Metcalf, W, Mewes, M, Meyer, H, Miao, T, Michna, G, Miedema, T, Migenda, J, Milincic, R, Miller, W, Mills, J, Milne, C, Mineev, O, Miranda, O, Miryala, S, Mishra, C, Mishra, S, Mislivec, A, Mladenov, D, Mocioiu, I, Moffat, K, Moggi, N, Mohanta, R, Mohayai, T, Mokhov, N, Molina, J, Molina Bueno, L, Montanari, A, Montanari, C, Montanari, D, Montano Zetina, L, Moon, J, Mooney, M, Moor, A, Moreno, D, Morgan, B, Morris, C, Mossey, C, Motuk, E, Moura, C, Mousseau, J, Mu, W, Mualem, L, Mueller, J, Muether, M, Mufson, S, Muheim, F, Muir, A, Mulhearn, M, Muramatsu, H, Murphy, S, Musser, J, Nachtman, J, Nagu, S, Nalbandyan, 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C, Svoboda, R, Szczerbinska, B, Szelc, A, Talaga, R, Tanaka, H, Tapia Oregui, B, Tapper, A, Tariq, S, Tatar, E, Tayloe, R, Teklu, A, Tenti, M, Terao, K, Ternes, C, Terranova, F, Testera, G, Thea, A, Thompson, J, Thorn, C, Timm, S, Tonazzo, A, Torti, M, Tortola, M, Tortorici, F, Totani, D, Toups, M, Touramanis, C, Trevor, J, Trzaska, W, Tsai, Y, Tsamalaidze, Z, Tsang, K, Tsverava, N, Tufanli, S, Tull, C, Tyley, E, Tzanov, M, Uchida, M, Urheim, J, Usher, T, Vagins, M, Vahle, P, Valdiviesso, G, Valencia, E, Vallari, Z, Valle, J, Vallecorsa, S, Van Berg, R, Van De Water, R, Vanegas Forero, D, Varanini, F, Vargas, D, Varner, G, Vasel, J, Vasseur, G, Vaziri, K, Ventura, S, Verdugo, A, Vergani, S, Vermeulen, M, Verzocchi, M, Vieira De Souza, H, Vignoli, C, Vilela, C, Viren, B, Vrba, T, Wachala, T, Waldron, A, Wallbank, M, Wang, H, Wang, J, Wang, Y, Warburton, K, Warner, D, Wascko, M, Waters, D, Watson, A, Weatherly, P, Weber, A, Weber, M, Wei, H, Weinstein, A, Wenman, D, Wetstein, M, While, M, White, A, Whitehead, L, Whittington, D, Wilking, M, Wilkinson, C, Williams, Z, Wilson, F, Wilson, R, Wolcott, J, Wongjirad, T, Wood, K, Wood, L, Worcester, E, Worcester, M, Wret, C, Wu, W, Xiao, Y, Yang, G, Yang, T, Yershov, N, Yonehara, K, Young, T, Yu, B, Yu, J, Zaki, R, Zalesak, J, Zambelli, L, Zamorano, B, Zani, A, Zazueta, L, Zeller, G, Zennamo, J, Zeug, K, Zhang, C, Zhao, M, Zhivun, E, Zhu, G, Zimmerman, E, Zito, M, Zucchelli, S, Zuklin, J, Zutshi, V, Zwaska, R, Abi B., Acciarri R., Acero M.A., Adamov G., Adams D., Adinolfi M., Ahmad Z., Ahmed J., Alion T., Alonso Monsalve S., Alt C., Anderson J., Andreopoulos C., Andrews M.P., Andrianala F., Andringa S., Ankowski A., Antonova M., Antusch S., Aranda-Fernandez A., Ariga A., Arnold L.O., Arroyave M.A., Asaadi J., Aurisano A., Aushev V., Autiero D., Azfar F., Back H., Back J.J., Backhouse C., Baesso P., Bagby L., Bajou R., Balasubramanian S., Baldi P., Bambah B., Barao F., Barenboim G., Barker G.J., Barkhouse W., Barnes C., Barr G., Barranco Monarca J., Barros N., Barrow J.L., Bashyal A., Basque V., Bay F., Bazo Alba J.L., Beacom J.F., Bechetoille E., Behera B., Bellantoni L., Bellettini G., Bellini V., Beltramello O., Belver D., Benekos N., Bento Neves F., Berger J., Berkman S., Bernardini P., Berner R.M., Berns H., Bertolucci S., Betancourt M., Bezawada Y., Bhattacharjee M., Bhuyan B., Biagi S., Bian J., Biassoni M., Biery K., Bilki B., Bishai M., Bitadze A., Blake A., Blanco Siffert B., Blaszczyk F.D.M., Blazey G.C., Blucher E., Boissevain J., Bolognesi S., Bolton T., Bonesini M., Bongrand M., Bonini F., Booth A., Booth C., Bordoni S., Borkum A., Boschi T., Bostan N., Bour P., Boyd S.B., Boyden D., Bracinik J., Braga D., Brailsford D., Brandt A., Bremer J., Brew C., Brianne E., Brice S.J., Brizzolari C., Bromberg C., Brooijmans G., Brooke J., Bross A., Brunetti G., Buchanan N., Budd H., Caiulo D., Calafiura P., Calcutt J., Calin M., Calvez S., Calvo E., Camilleri L., Caminata A., Campanelli M., Caratelli D., Carini G., Carlus B., Carniti P., Caro Terrazas I., Carranza H., Castillo A., Castromonte C., Cattadori C., Cavalier F., Cavanna F., Centro S., Cerati G., Cervelli A., Cervera Villanueva A., Chalifour M., Chang C., Chardonnet E., Chatterjee A., Chattopadhyay S., Chaves J., Chen H., Chen M., Chen Y., Cherdack D., Chi C., Childress S., Chiriacescu A., Cho K., Choubey S., Christensen A., Christian D., Christodoulou G., Church E., Clarke P., Coan T.E., Cocco A.G., Coelho J.A.B., Conley E., Conrad J.M., Convery M., Corwin L., Cotte P., Cremaldi L., Cremonesi L., Crespo-Anadon J.I., Cristaldo E., Cross R., Cuesta C., Cui Y., Cussans D., Dabrowski M., Da Motta H., Da Silva Peres L., David C., David Q., Davies G.S., Davini S., Dawson J., De K., De Almeida R.M., Debbins P., De Bonis I., Decowski M.P., De Gouvea A., De Holanda P.C., De Icaza Astiz I.L., Deisting A., De Jong P., Delbart A., Delepine D., Delgado M., Dell'acqua A., De Lurgio P., De Mello Neto J.R.T., Demuth D.M., Dennis S., Densham C., Deptuch G., De Roeck A., De Romeri V., De Vries J.J., Dharmapalan R., Dias M., Diaz F., Diaz J.S., Di Domizio S., Di Giulio L., Ding P., Di Noto L., Distefano C., Diurba R., Diwan M., Djurcic Z., Dokania N., Dolinski M.J., Domine L., Douglas D., Drielsma F., Duchesneau D., Duffy K., Dunne P., Durkin T., Duyang H., Dvornikov O., Dwyer D.A., Dyshkant A.S., Eads M., Edmunds D., Eisch J., Emery S., Ereditato A., Escobar C.O., Escudero Sanchez L., Evans J.J., Ewart E., Ezeribe A.C., Fahey K., Falcone A., Farnese C., Farzan Y., Felix J., Fernandez-Martinez E., Fernandez Menendez P., Ferraro F., Fields L., Filkins A., Filthaut F., Fitzpatrick R.S., Flanagan W., Fleming B., Flight R., Fowler J., Fox W., Franc J., Francis K., Franco D., Freeman J., Freestone J., Fried J., Friedland A., Fuess S., Furic I., Furmanski A.P., Gago A., Gallagher H., Gallego-Ros A., Gallice N., Galymov V., Gamberini E., Gamble T., Gandhi R., Gandrajula R., Gao S., Garcia-Carballeira F., Garcia-Gamez D., Garcia-Peris M.A., Gardiner S., Gastler D., Ge G., Gelli B., Gendotti A., Gent S., Ghorbani-Moghaddam Z., Gibin D., Gil-Botella I., Girerd C., Giri A.K., Gnani D., Gogota O., Gold M., Gollapinni S., Gollwitzer K., Gomes R.A., Gomez Bermeo L.V., Gomez Fajardo L.S., Gonnella F., Gonzalez-Cuevas J.A., Goodman M.C., Goodwin O., Goswami S., Gotti C., Goudzovski E., Grace C., Graham M., Gramellini E., Gran R., Granados E., Grant A., Grant C., Gratieri D., Green P., Green S., Greenler L., Greenwood M., Greer J., Griffith W.C., Groh M., Grudzinski J., Grzelak K., Gu W., Guarino V., Guenette R., Guglielmi A., Guo B., Guthikonda K.K., Gutierrez R., Guzowski P., Guzzo M.M., Gwon S., Habig A., Hackenburg A., Hadavand H., Haenni R., Hahn A., Haigh J., Haiston J., Hamernik T., Hamilton P., Han J., Harder K., Harris D.A., Hartnell J., Hasegawa T., Hatcher R., Hazen E., Heavey A., Heeger K.M., Heise J., Hennessy K., Henry S., Hernandez Morquecho M.A., Herner K., Hertel L., Hesam A.S., Hewes J., Higuera A., Hill T., Hillier S.J., Himmel A., Hoff J., Hohl C., Holin A., Hoppe E., Horton-Smith G.A., Hostert M., Hourlier A., Howard B., Howell R., Huang J., Hugon J., Iles G., Ilic N., Iliescu A.M., Illingworth R., Ioannisian A., Itay R., Izmaylov A., James E., Jargowsky B., Jediny F., Jesus-Valls C., Ji X., Jiang L., Jimenez S., Jipa A., Joglekar A., Johnson C., Johnson R., Jones B., Jones S., Jung C.K., Junk T., Jwa Y., Kabirnezhad M., Kaboth A., Kadenko I., Kamiya F., Karagiorgi G., Karcher A., Karolak M., Karyotakis Y., Kasai S., Kasetti S.P., Kashur L., Kazaryan N., Kearns E., Keener P., Kelly K.J., Kemp E., Ketchum W., Kettell S.H., Khabibullin M., Khotjantsev A., Khvedelidze A., Kim D., King B., Kirby B., Kirby M., Klein J., Koehler K., Koerner L.W., Kohn S., Koller P.P., Kordosky M., Kosc T., Kose U., Kostelecky V.A., Kothekar K., Krennrich F., Kreslo I., Kudenko Y., Kudryavtsev V.A., Kulagin S., Kumar J., Kumar R., Kuruppu C., Kus V., Kutter T., Lambert A., Lande K., Lane C.E., Lang K., Langford T., Lasorak P., Last D., Lastoria C., Laundrie A., Lawrence A., Lazanu I., Lazur R., Le T., Learned J., Lebrun P., Lehmann Miotto G., Lehnert R., Leigui De Oliveira M.A., Leitner M., Leyton M., Li L., Li S., Li S.W., Li T., Li Y., Liao H., Lin C.S., Lin S., Lister A., Littlejohn B.R., Liu J., Lockwitz S., Loew T., Lokajicek M., Lomidze I., Long K., Loo K., Lorca D., Lord T., Losecco J.M., Louis W.C., Luk K.B., Luo X., Lurkin N., Lux T., Luzio V.P., MacFarland D., MacHado A.A., MacHado P., MacIas C.T., MacIer J.R., Maddalena A., Madigan P., Magill S., Mahn K., Maio A., Maloney J.A., Mandrioli G., Maneira J., Manenti L., Manly S., Mann A., Manolopoulos K., Manrique Plata M., Marchionni A., Marciano W., Marfatia D., Mariani C., Maricic J., Marinho F., Marino A.D., Marshak M., Marshall C., Marshall J., Marteau J., Martin-Albo J., Martinez N., Martinez Caicedo D.A., Martynenko S., Mason K., Mastbaum A., Masud M., Matsuno S., Matthews J., Mauger C., Mauri N., Mavrokoridis K., Mazza R., Mazzacane A., Mazzucato E., McCluskey E., McConkey N., McFarland K.S., McGrew C., McNab A., Mefodiev A., Mehta P., Melas P., Mellinato M., Mena O., Menary S., Mendez H., Menegolli A., Meng G., Messier M.D., Metcalf W., Mewes M., Meyer H., Miao T., Michna G., Miedema T., Migenda J., Milincic R., Miller W., Mills J., Milne C., Mineev O., Miranda O.G., Miryala S., Mishra C.S., Mishra S.R., Mislivec A., Mladenov D., Mocioiu I., Moffat K., Moggi N., Mohanta R., Mohayai T.A., Mokhov N., Molina J., Molina Bueno L., Montanari A., Montanari C., Montanari D., Montano Zetina L.M., Moon J., Mooney M., Moor A., Moreno D., Morgan B., Morris C., Mossey C., Motuk E., Moura C.A., Mousseau J., Mu W., Mualem L., Mueller J., Muether M., Mufson S., Muheim F., Muir A., Mulhearn M., Muramatsu H., Murphy S., Musser J., Nachtman J., Nagu S., Nalbandyan M., Nandakumar R., Naples D., Narita S., Navas-Nicolas D., Nayak N., Nebot-Guinot M., Necib L., Negishi K., Nelson J.K., Nesbit J., Nessi M., Newbold D., Newcomer M., Newhart D., Nichol R., Niner E., Nishimura K., Norman A., Norrick A., Northrop R., Novella P., Nowak J.A., Oberling M., Olivares Del Campo A., Olivier A., Onel Y., Onishchuk Y., Ott J., Pagani L., Pakvasa S., Palamara O., Palestini S., Paley J.M., Pallavicini M., Palomares C., Pantic E., Paolone V., Papadimitriou V., Papaleo R., Papanestis A., Paramesvaran S., Parke S., Parsa Z., Parvu M., Pascoli S., Pasqualini L., Pasternak J., Pater J., Patrick C., Patrizii L., Patterson R.B., Patton S.J., Patzak T., Paudel A., Paulos B., Paulucci L., Pavlovic Z., Pawloski G., Payne D., Pec V., Peeters S.J.M., Penichot Y., Pennacchio E., Penzo A., Peres O.L.G., Perry J., Pershey D., Pessina G., Petrillo G., Petta C., Petti R., Piastra F., Pickering L., Pietropaolo F., Pillow J., Pinzino J., Plunkett R., Poling R., Pons X., Poonthottathil N., Pordes S., Potekhin M., Potenza R., Potukuchi B.V.K.S., Pozimski J., Pozzato M., Prakash S., Prakash T., Prince S., Prior G., Pugnere D., Qi K., Qian X., Raaf J.L., Raboanary R., Radeka V., Rademacker J., Radics B., Radovic A., Rafique A., Raguzin E., Rai M., Rajaoalisoa M., Rakhno I., Rakotondramanana H.T., Rakotondravohitra L., Ramachers Y.A., Rameika R., Ramirez Delgado M.A., Ramson B., Rappoldi A., Raselli G., Ratoff P., Ravat S., Razafinime H., Real J.S., Rebel B., Redondo D., Reggiani-Guzzo M., Rehak T., Reichenbacher J., Reitzner S.D., Renshaw A., Rescia S., Resnati F., Reynolds A., Riccobene G., Rice L.C.J., Rielage K., Rigaut Y., Rivera D., Rochester L., Roda M., Rodrigues P., Rodriguez Alonso M.J., Rodriguez Rondon J., Roeth A.J., Rogers H., Rosauro-Alcaraz S., Rossella M., Rout J., Roy S., Rubbia A., Rubbia C., Russell B., Russell J., Ruterbories D., Saakyan R., Sacerdoti S., Safford T., Sahu N., Sala P., Samios N., Sanchez M.C., Sanders D.A., Sankey D., Santana S., Santos-Maldonado M., Saoulidou N., Sapienza P., Sarasty C., Sarcevic I., Savage G., Savinov V., Scaramelli A., Scarff A., Scarpelli A., Schaffer T., Schellman H., Schlabach P., Schmitz D., Scholberg K., Schukraft A., Segreto E., Sensenig J., Seong I., Sergi A., Sergiampietri F., Sgalaberna D., Shaevitz M.H., Shafaq S., Shamma M., Sharma H.R., Sharma R., Shaw T., Shepherd-Themistocleous C., Shin S., Shooltz D., Shrock R., Simard L., Simos N., Sinclair J., Sinev G., Singh J., Singh V., Sipos R., Sippach F.W., Sirri G., Sitraka A., Siyeon K., Smargianaki D., Smith A., Smith E., Smith P., Smolik J., Smy M., Snopok P., Soares Nunes M., Sobel H., Soderberg M., Solano Salinas C.J., Soldner-Rembold S., Solomey N., Solovov V., Sondheim W.E., Sorel M., Soto-Oton J., Sousa A., Soustruznik K., Spagliardi F., Spanu M., Spitz J., Spooner N.J.C., Spurgeon K., Staley R., Stancari M., Stanco L., Steiner H.M., Stewart J., Stillwell B., Stock J., Stocker F., Stokes T., Strait M., Strauss T., Striganov S., Stuart A., Summers D., Surdo A., Susic V., Suter L., Sutera C.M., Svoboda R., Szczerbinska B., Szelc A.M., Talaga R., Tanaka H.A., Tapia Oregui B., Tapper A., Tariq S., Tatar E., Tayloe R., Teklu A.M., Tenti M., Terao K., Ternes C.A., Terranova F., Testera G., Thea A., Thompson J.L., Thorn C., Timm S.C., Tonazzo A., Torti M., Tortola M., Tortorici F., Totani D., Toups M., Touramanis C., Trevor J., Trzaska W.H., Tsai Y.T., Tsamalaidze Z., Tsang K.V., Tsverava N., Tufanli S., Tull C., Tyley E., Tzanov M., Uchida M.A., Urheim J., Usher T., Vagins M.R., Vahle P., Valdiviesso G.A., Valencia E., Vallari Z., Valle J.W.F., Vallecorsa S., Van Berg R., Van De Water R.G., Vanegas Forero D., Varanini F., Vargas D., Varner G., Vasel J., Vasseur G., Vaziri K., Ventura S., Verdugo A., Vergani S., Vermeulen M.A., Verzocchi M., Vieira De Souza H., Vignoli C., Vilela C., Viren B., Vrba T., Wachala T., Waldron A.V., Wallbank M., Wang H., Wang J., Wang Y., Warburton K., Warner D., Wascko M., Waters D., Watson A., Weatherly P., Weber A., Weber M., Wei H., Weinstein A., Wenman D., Wetstein M., While M.R., White A., Whitehead L.H., Whittington D., Wilking M.J., Wilkinson C., Williams Z., Wilson F., Wilson R.J., Wolcott J., Wongjirad T., Wood K., Wood L., Worcester E., Worcester M., Wret C., Wu W., Xiao Y., Yang G., Yang T., Yershov N., Yonehara K., Young T., Yu B., Yu J., Zaki R., Zalesak J., Zambelli L., Zamorano B., Zani A., Zazueta L., Zeller G.P., Zennamo J., Zeug K., Zhang C., Zhao M., Zhivun E., Zhu G., Zimmerman E.D., Zito M., Zucchelli S., Zuklin J., Zutshi V., Zwaska R., UAM. Departamento de Física Teórica, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Ministerio de Ciencia, Innovación y Universidades (España)

Subjects
Neutrino Oscillations. Neutrino detectors, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, far detector, 01 natural sciences, Physics, Particles & Fields, High Energy Physics - Experiment, charged current, High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Particle Physics Experiments, Muon neutrino, neutrino/e: particle identification, Neutrino detectors, Detectors and Experimental Techniques, physics.ins-det, Charged current, neutrino: interaction, Informática, Physics, Telecomunicaciones, Neutrino oscillations, Neutrino interactions, neural network, DUNE, Deep Underground Neutrino Experiment, Instrumentation and Detectors (physics.ins-det), Experiment (hep-ex), Neutrino detector, Physical Sciences, CP violation, Neutrino, Particle Physics - Experiment, Particle physics, data analysis method, 530 Physics, neural network, Astrophysics::High Energy Astrophysical Phenomena, CONSERVATION, FOS: Physical sciences, Astronomy & Astrophysics, Deep Learning, neutrino: deep underground detector, neutrino physics, 0103 physical sciences, Object Detection, CP: violation, Deep Underground Neutrino Experiment, High Energy Physics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Neutrinos, 010306 general physics, Neutrino oscillation, neutrino/mu: particle identification, IOU, Science & Technology, DUNE, Neutrino interactions, 010308 nuclear & particles physics, hep-ex, High Energy Physics::Phenomenology, Física, Neutrino Interaction, Detector, 530 Physik, sensitivity, efficiency, High Energy Physics::Experiment, Electron neutrino
Abstract

The Deep Underground Neutrino Experiment is a next-generation neutrino oscillation experiment that aims to measure CP-violation in the neutrino sector as part of a wider physics program. A deep learning approach based on a convolutional neural network has been developed to provide highly efficient and pure selections of electron neutrino and muon neutrino charged-current interactions. The electron neutrino (antineutrino) selection efficiency peaks at 90% (94%) and exceeds 85% (90%) for reconstructed neutrino energies between 2–5 GeV. The muon neutrino (antineutrino) event selection is found to have a maximum efficiency of 96% (97%) and exceeds 90% (95%) efficiency for reconstructed neutrino energies above 2 GeV. When considering all electron neutrino and antineutrino interactions as signal, a selection purity of 90% is achieved. These event selections are critical to maximize the sensitivity of the experiment to CP-violating effects., Fermi Research Alliance, LLC (FRA) DE-AC02-07CH11359, National Council for Scientific and Technological Development (CNPq), Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ), FAPEG, Brazil, Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Canada Foundation for Innovation, Institute of Particle Physics, Canada, Natural Sciences and Engineering Research Council of Canada (NSERC), CERN, Ministry of Education, Youth & Sports - Czech Republic Czech Republic Government, ERDF, European Union, H2020-EU, European Union, MSCA, European Union, Centre National de la Recherche Scientifique (CNRS), French Atomic Energy Commission, Istituto Nazionale di Fisica Nucleare (INFN), Portuguese Foundation for Science and Technology European Commission, NRF, South Korea, Comunidad de Madrid, La Caixa Foundation, Spanish Government, State Secretariat for Education, Research and Innovation, Switzerland, Swiss National Science Foundation (SNSF), Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK), Royal Society of London, UKRI/STFC, United Kingdom, United States Department of Energy (DOE), National Science Foundation (NSF)

Published
2020

24. Biocatalytic Conversion of 5-Hydroxymethylfurfural by Galactose Oxidase: Toward Scalable Technology Using Integrated Process and Enzyme Engineering

Author

Mathias Bøje Madsen, Michael Breuer, Nicholas J. Turner, John M. Woodley, William R. Birmingham, Mafalda Dias Gomes, and Asbjørn Toftgaard Pedersen

Subjects
Chemistry, Galactose oxidase, Scientific method, 5-hydroxymethylfurfural, Scalability, High activity, Biochemical engineering, Protein engineering, Directed evolution, Renewable resource
Abstract

5-Hydroxymethylfurfural (HMF) has emerged as a crucial bio-based chemical building block in the drive towards developing materials from renewable resources, due to its direct preparation from sugars and its readily diversifiable scaffold. A key obstacle in transitioning to bio-based plastic production lies in meeting the necessary industrial production efficiency, particularly in the cost-effective conversion of HMF to valuable intermediates. To address the challenge of developing scalable technology for oxidizing crude HMF to more valuable chemicals, we have integrated process and enzyme engineering to provide a galactose oxidase (GOase) variant with remarkably high activity toward HMF, improved O2 binding and excellent productivity (>1,000,000 TTN). The process concept presented here for GOase catalysed selective oxidation of HMF to 2,5-diformylfuran offers a productive and efficient platform for further development, thereby laying the groundwork for a biocatalytic route to scalable production of furan-based chemical building blocks from sustainable feedstocks.

Published
2020

25. Volume IV The DUNE far detector single-phase technology

Author

L. Di Giulio, J. Martin-Albo, S. Ravat, W. Mu, D. Marfatia, T. Kosc, D. Autiero, Poonam Mehta, A. Borkum, N. McConkey, G. Karagiorgi, Robert Wilson, L. M. Cremaldi, Stephen P. Gent, T. Young, Julián Félix, D. MacFarland, Andrew Smith, M. Manrique Plata, J. Freestone, D. Rivera, B. Stillwell, Marco Verzocchi, A. Lambert, Orlando L. G. Peres, K. Gollwitzer, E. Kemp, G. Yang, I. Kreslo, F. Varanini, M. Chalifour, A. Holin, S. J. Patton, R. J. Nichol, Giovanni Bellettini, V. A. Kudryavtsev, M. Sorel, E. Church, S. Kasai, H. O. Back, A. Lister, S. Santana, C. Mariani, Carlos Escobar, J. C. Freeman, Kaushik De, M. J. Rodriguez Alonso, M. A. Acero, A. Christensen, G. S. Varner, S. Sacerdoti, D. Shooltz, Seodong Shin, M. Santos-Maldonado, T. Schaffer, Jeremy Wolcott, J. Vasel, J. A. Gonzalez-Cuevas, J. Franc, C. Mossey, Jonas Rademacker, G. P. Zeller, Joshua Barrow, John Marshall, Alessandro Thea, H. A. Tanaka, W. C. Louis, E. Hazen, Armin Karcher, D. Smargianaki, Christopher L. Marshall, M. Soderberg, A. C. Weber, Christopher J. Milne, E. Brianne, A. Aranda-Fernandez, J. Calcutt, K. Warburton, M. Nalbandyan, Dave Sankey, J. Asaadi, F. Diaz, E. Valencia, B. Kirby, A. Bross, K. Koehler, M. A. Uchida, Y. Bezawada, D. Warner, C. E. Thorn, Srubabati Goswami, Z. Williams, Gregory Iles, A. Friedland, K. M. Heeger, V. P. Luzio, G. C. Blazey, J. Barranco Monarca, Carl Grace, A. M. Gago, E. James, M. Newcomer, H. W. Sobel, Roberto Gutiérrez, C. Vignoli, R. Hatcher, M. Zhao, F. Cavalier, M. A. Hernandez Morquecho, N. Poonthottathil, Ara Ioannisian, W. Metcalf, T. Wongjirad, H. T. Rakotondramanana, D. Cherdack, M. A. Ramirez Delgado, R. Diurba, G. Christodoulou, S. Calvez, T. Durkin, H. Y. Wei, M. Muether, S. Roy, A. Caminata, A. Scarpelli, Christopher Brew, Pavel Snopok, Y. Rigaut, L. Escudero Sanchez, K. Kothekar, W. Flanagan, V. Papadimitriou, S. J. Brice, Nicolas Lurkin, M. V. Diwan, Andrew White, S. Berkman, H. Muramatsu, Z. Pavlovic, A. A. Machado, Christian Farnese, A. Mastbaum, Alfredo G. Cocco, G. Zhu, S. Centro, S. Henry, J. Rout, P. de Jong, H. Carranza, Milos Lokajicek, K. Nishimura, A. Delbart, N. J. C. Spooner, C. McGrew, E. Pantic, Mario Campanelli, David Cussans, B. T. Fleming, K. Negishi, F. Spagliardi, J. Nesbit, André Rubbia, Akitaka Ariga, Marvin L Marshak, F. Pietropaolo, F. D. M. Blaszczyk, T. Hasegawa, Kate Scholberg, O. Gogota, R. Poling, Simon Jones, A. Tonazzo, M. P. Andrews, R. Petti, S. Bertolucci, M. Bonesini, A. F. Moor, C. Barnes, A. S. Hesam, S. H. Kettell, M. Bongrand, M. R. While, D. J. Payne, C. Gotti, A. Chiriacescu, Paul Keener, Leigh H. Whitehead, James Stewart, A. Mazzacane, L. W. Koerner, T. Rehak, C. Andreopoulos, F. Terranova, Jaroslaw Pasternak, E. Raguzin, L. C. J. Rice, J. L. Bazo Alba, S. Li, J. Hartnell, M. Potekhin, N. Moggi, D. J. Summers, J. Berger, L. Cremonesi, Katsuya Yonehara, T. E. Coan, Claire Shepherd-Themistocleous, B. Radics, Karol Hennessy, S. Söldner-Rembold, C. S. Lin, L. Greenler, B. Guo, Frank Filthaut, R. B. Patterson, E. Pennacchio, E. Zhivun, C. Cuesta, T. Loew, G. Prior, D. Duchesneau, Lina Necib, S. Rescia, W. Gu, Andrés Castillo, N. Kazaryan, O. G. Miranda, C. Patrick, Robert Shrock, José W. F. Valle, J. Reichenbacher, D. A. Sanders, John F. Beacom, S. Tufanli, S. Ventura, Riccardo Papaleo, J. Zennamo, A. De Roeck, M. Calin, P. Ding, Alessandro Menegolli, B. V. K. S. Potukuchi, T. Le, T. Wachala, L. O. Arnold, J. R. Macier, A. M. Teklu, E. Blucher, L. Hertel, F. W. Sippach, S. Childress, T. Miao, P. Fernandez Menendez, J. Han, R. Gandrajula, C. Y. Chi, Marzio Nessi, Aldo Penzo, Ina Sarcevic, Kendall Mahn, Jorge Molina, F. Bonini, Eric W. Hoppe, M. Groh, Barry King, R. Mazza, Keith Rielage, Patrick Dunne, M. Mellinato, D. Lorca, R. Guenette, F. Bento Neves, L. Pickering, Manuel Alejandro Segura Delgado, J. J. Russell, H. R. Gallagher, J. Zuklin, Steven Gardiner, P. Madigan, D. Douglas, Daniel Gastler, S. Manly, P. Hamilton, L. Montaño Zetina, R. G. Van de Water, S. Dennis, M. Tenti, N. Dokania, Kim Siyeon, E. Fernandez-Martinez, P. P. Koller, D. Whittington, T. Li, M. C. Sanchez, S. Biagi, C. Sarasty, Juraj Bracinik, A. N. Khotjantsev, N. Tsverava, Yasaman Farzan, M. Tzanov, J. G. Boissevain, J. Smolik, Andrew Brandt, J. Hoff, D. A. Harris, C. Distefano, Ornella Palamara, H. S. Budd, Alastair Grant, A. K. Giri, Thorsten Lux, C. E. Lane, J. Marteau, Irakli Lomidze, E. Kearns, Zviad Tsamalaidze, L. S. Gomez Fajardo, H. da Motta, J. S. Real, Sukalyan Chattopadhyay, B. Viren, J. Mousseau, Ihn Sik Seong, C. M. Sutera, A. C. Ezeribe, F. Ferraro, Marco Adinolfi, Nikolaos Simos, A. Stuart, D. Brailsford, N. Solomey, Laura Manenti, L. V. Gomez Bermeo, Andrea Zani, Kristian Harder, Timothy M. Shaw, J. Hewes, Sandro Palestini, D. Braga, D. Garcia-Gamez, J. Stock, S. Bolognesi, D. Belver, Laura Paulucci, J. Ahmed, Narendra Sahu, Sandip Pakvasa, L. Pasqualini, D. Mladenov, M. Kordosky, S. Zucchelli, L. Stanco, M. Torti, B. Jargowsky, E. Smith, C. J. Solano Salinas, N.V. Mokhov, D. Vanegas Forero, C. Jesús-Valls, Andrew Blake, L. Jiang, F. Andrianala, W. Ketchum, Matthaeus Leitner, K. Fahey, Marco Pallavicini, Bindu A. Bambah, K. Francis, M. H. Shaevitz, N. Barros, I. Caro Terrazas, R. Itay, G. Sirri, H. Steiner, Laura Dominé, S. Lockwitz, G. Savage, N. Bostan, J. A. Nowak, A. Scarff, Konstantinos Manolopoulos, R. K. Plunkett, B. Morgan, A. Rafique, Cari L. Johnson, M. Parvu, L. Patrizii, James A. Anderson, L. Corwin, A. Hourlier, S. L. Mufson, S. Martynenko, V. J. Guarino, B. Carlus, D. Boyden, F. Marinho, David Delepine, J. Bremer, Paola Sala, P. Cotte, J.V. Dawson, G. Mandrioli, O. Goodwin, Jitendra Kumar, Ph. Lebrun, J. Soto-Oton, K. K. Guthikonda, Evgueni Goudzovski, Gabriella Carini, S. Gao, M. Dabrowski, Sudarshan Paramesvaran, G. Pessina, S. Davini, R. L. Talaga, Francesco Gonnella, A. Joglekar, G. Sinev, S. Gwon, A. Surdo, M. O. Wascko, R. Bajou, Pedro A. N. Machado, Massimo Rossella, G. S. Davies, I. De Bonis, K. S. McFarland, C. T. Macias, T. Alion, O. V. Mineev, M. Bishai, R. Northrop, Chao Zhang, R. Van Berg, L. Di Noto, Kam-Biu Luk, J. Chaves, J. Wang, K. Qi, W. E. Sondheim, Sergei Striganov, B. Paulos, Janice L. Thompson, M. Rai, P. N. Ratoff, T. Kutter, D. Totani, J. A. B. Coelho, F. Stocker, T. Gamble, J. J. Grudzinski, I. Gil-Botella, T. Yang, Wayne A. Barkhouse, C. E. Tull, H. Mendez, Z. Ghorbani-Moghaddam, Y.-J. Jwa, F. Cavanna, F. Kamiya, V. Basque, R. Sipos, V. Bellini, C. Alt, Sandhya Choubey, B. Abi, A. Mefodiev, V. A. Kostelecky, A. L. Renshaw, Giuseppe Benedetto Cerati, S. Balasubramanian, M. Biassoni, D. Pershey, J. Maricic, K. Lande, A. Muir, L.S. Rochester, A. Papanestis, A. Aurisano, F. Bay, R. Nandakumar, T. L. Usher, Bo Yu, A. V. Waldron, A. Filkins, Y. Cui, P. A. Rodrigues, Daijin Kim, G.D. Barr, Junwei Huang, V. De Romeri, H.E. Rogers, Andrea Dell'Acqua, A. Cervera Villanueva, Robert Svoboda, Yu. Onishchuk, T. Hamernik, A. P. Furmanski, M. Wetstein, P.T. Smith, G. Brunetti, Mariam Tórtola, Matthew L Strait, G. Barenboim, P. Guzowski, J. D. Eisch, N. Gallice, D. Newhart, A. J. Roeth, H. Berns, E. Granados, A. Weinstein, A. Falcone, D. Caratelli, L. Bellantoni, Wei Wu, J. Mills, A. Hackenburg, D. Caiulo, Chia-Chan Chang, Dave M Newbold, C. K. Jung, F. Krennrich, G. Testera, S. Rosauro-Alcaraz, A. Sitraka, L. Bagby, J. M. LoSecco, S. Tariq, C. Mauger, J. J. Back, J. Yu, R. Acciarri, B. Behera, P. Lasorak, Karol Lang, Irina Mocioiu, H. Schellman, Han Wang, Sergey A. Kulagin, A. Bashyal, Beatriz B. Siffert, C. N. Booth, L. Zambelli, M. T. Graham, A. Mann, Rakesh Kumar, Y. Xiao, Gregory J Pawloski, T. Prakash, Arsen Khvedelidze, A.S. Dyshkant, Paolo Carniti, C. Rubbia, M. Reggiani-Guzzo, M. M. Khabibullin, D. Wenman, S. C. Timm, R. Sharma, R. Saakyan, Marcelo M. Guzzo, P. Baesso, M. Pozzato, T. R. Junk, C. Morris, A. Cervelli, A. Heavey, Grzegorz Deptuch, M. Á. García-Peris, B. Bhuyan, M. Kabirnezhad, Pierre Baldi, M. Mooney, E. Tyley, A. Hahn, V. Susic, S. D. Reitzner, M. P. Decowski, V. Galymov, E. Chardonnet, B. R. Littlejohn, B. Ramson, B. Russell, M. Vagins, L. Fields, V. Zutshi, Sandeep Miryala, Enrique Calvo, V. Radeka, P. Debbins, J. Sinclair, B. Bilki, C. Touramanis, J. I. Crespo-Anadón, J. M. Paley, Antonio Ereditato, N. Yershov, C. J. Densham, D. W. Schmitz, A. Gallego-Ros, N. Buchanan, N. Mauri, A. Lawrence, K. Cho, S. Narita, X. Luo, A. Booth, D. A. Dwyer, S. Prince, J. Haiston, Jianbei Liu, T. J. Langford, E. Gamberini, Matheus Hostert, Dario Gnani, P. Vahle, G. A. Horton-Smith, A. Marchionni, I. K. Furic, John Matthews, K. Mason, M. Bhattacharjee, Randall P. Johnson, Amelia Maio, E. Motuk, C. Castromonte, Paolo Calafiura, Q. David, T. Miedema, S. Magill, Z. Ahmad, John Evans, Yi Chen, E. Ewart, S. Gollapinni, K. V. Tsang, J. Maneira, R.A. Rameika, A. de Gouvea, M. A. Vermeulen, R. M. Berner, J. J. De Vries, S. Shafaq, L. Da Silva Peres, A. McNab, G. Vasseur, A. Verdugo, C. Petta, Kenneth Long, H. S. Chen, K. Mavrokoridis, M. J. Dolinski, Yu. Kudenko, D. Gratieri, Alexandru Jipa, J. R. T. de Mello Neto, Olga Beltramello, J. T. Haigh, B. Gelli, Gregory J. Michna, A. M. Iliescu, Alex Reynolds, K. Biery, Yanchu Wang, V. Aushev, J. Zalesak, L. Simard, Ionel Lazanu, L. Pagani, J. Rodriguez Rondon, Alec Habig, M. Nebot-Guinot, R. Illingworth, G. Petrillo, J. S. Díaz, P. Novella, K. Grzelak, A. Gendotti, A. Himmel, M. Rajaoalisoa, P. Bour, L. Mualem, D. Pugnere, E. Niner, C. A. Moura, A. D. Marino, S. Bordoni, James Mueller, W. Fox, Jordan Ott, Niki Saoulidou, M. Oberling, E. Mazzucato, Silvia Pascoli, K. Herner, Hem Raj Sharma, M. Betancourt, T. Lord, L. Zazueta, Alexander Deisting, B. Rebel, Joleen Pater, David H. Adams, I. L. De Icaza Astiz, Stefan Antusch, M. Worcester, A. Higuera Pichardo, C. Kuruppu, Janet Conrad, Z. Parsa, Francesco Tortorici, L. Suter, J. Moon, P. E. L. Clarke, C. Palomares, Sofia Andringa, F. Jediny, J. Urheim, D. Montanari, Giorgio Riccobene, A. Rappoldi, J. Migenda, S. Matsuno, Y. Karyotakis, Jürgen Pozimski, Artur M. Ankowski, D. Edmunds, T. Safford, E. Tatar, Utku Kose, Z. Djurcic, D. Vargas, C. Wret, F. Sergiampietri, Rex Tayloe, F. Barao, I. Rakhno, Rukmani Mohanta, Andrew Norman, V. N. Solovov, X. Pons, V. Paolone, V. Pec, J. Pillow, S. Vergani, V. Savinov, P. Melas, Simon Lin, K. Wood, E. D. Zimmerman, M. A. Leigui de Oliveira, A. Olivier, Kevin J. Kelly, D. Sgalaberna, M. Gold, M. Spanu, Xiaolu Ji, A. M. Szelc, Gareth J. Barker, C. Cattadori, J. Fowler, S. J. M. Peeters, Raj Gandhi, M. Masud, R. LaZur, C. Grant, A. Olivares Del Campo, Joshua R. Klein, Vasundhara Singh, Ranjan Dharmapalan, Lynn Wood, E. Bechetoille, Patrick Green, Gustaaf Brooijmans, R. Howell, K. Moffat, J. G. Learned, J. Spitz, E. McCluskey, T. Patzak, M. D. Messier, J. A. Musser, R. Raboanary, P. Schlabach, C. Lastoria, D. Naples, Kazuhiro Terao, A. Paudel, Michael Mulhearn, S. B. Boyd, T. Hill, G. A. Valdiviesso, S. Emery, M. C. Goodman, D. C. Christian, S. Alonso Monsalve, B. Howard, G. Ge, Alexander Tapper, Thomas Strauss, J. Hugon, M. Kirby, K. Zeug, A. Laundrie, B. Szczerbinska, R. Flight, H. Vieira de Souza, D. M. DeMuth, A. Chatterjee, S. Kohn, F. Drielsma, A. Bitadze, B. Zamorano, Warner A. Miller, Yichen Li, Wladyslaw Henryk Trzaska, F. Piastra, C. Wilkinson, M. Greenwood, C. Girerd, R.J. Staley, R. Cross, S. Di Domizio, G. Meng, A. Mislivec, A. Sousa, K. Spurgeon, R. Gran, M. Roda, G.L. Raselli, R. S. Fitzpatrick, L. Rakotondravohitra, A. C. Kaboth, Matthew Mewes, Kai Loo, J. Trevor, T. Vrba, S. P. Kasetti, Y. Penichot, M. J. Wilking, M. Zito, S. Pordes, P. Weatherly, James John Brooke, M. Wallbank, F. F. Wilson, Nektarios Benekos, Renato Potenza, M. Toups, H. Y. Liao, Haleh Khani Hadavand, D. Redondo, S. R. Mishra, R. A. Gomes, E. Gramellini, S. Menary, P. C. de Holanda, D. Gibin, M. Stancari, B. J. P. Jones, C. Vilela, B. Tapia Oregui, N. Nayak, Sofia Vallecorsa, K. E. Duffy, E. Segreto, Xin Qian, T. A. Mohayai, Olga Mena, N. 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Molina Bueno, Science and Technology Facilities Council (STFC), Abi, B, Acciarri, R, Acero, M, Adamov, G, Adams, D, Adinolfi, M, Ahmad, Z, Ahmed, J, Alion, T, Monsalve, S, Alt, C, Anderson, J, Andreopoulos, C, Andrews, M, Andrianala, F, Andringa, S, Ankowski, A, Antonova, M, Antusch, S, Aranda-Fernandez, A, Ariga, A, Arnold, L, Arroyave, M, Asaadi, J, Aurisano, A, Aushev, V, Autiero, D, Azfar, F, Back, H, Back, J, Backhouse, C, Baesso, P, Bagby, L, Bajou, R, Balasubramanian, S, Baldi, P, Bambah, B, Barao, F, Barenboim, G, Barker, G, Barkhouse, W, Barnes, C, Barr, G, Monarca, J, Barros, N, Barrow, J, Bashyal, A, Basque, V, Bay, F, Alba, J, Beacom, J, Bechetoille, E, Behera, B, Bellantoni, L, Bellettini, G, Bellini, V, Beltramello, O, Belver, D, Benekos, N, Neves, F, Berger, J, Berkman, S, Bernardini, P, Berner, R, Berns, H, Bertolucci, S, Betancourt, M, Bezawada, Y, Bhattacharjee, M, Bhuyan, B, Biagi, S, Bian, J, Biassoni, M, Biery, K, Bilki, B, Bishai, M, Bitadze, A, Blake, A, Siffert, B, Blaszczyk, F, Blazey, G, Blucher, E, Boissevain, J, Bolognesi, S, Bolton, T, Bonesini, M, Bongrand, M, Bonini, F, Booth, A, Booth, C, Bordoni, S, Borkum, A, Boschi, T, Bostan, N, Bour, P, Boyd, S, Boyden, D, Bracinik, J, Braga, D, Brailsford, D, Brandt, A, Bremer, J, Brew, C, Brianne, E, Brice, S, Brizzolari, C, Bromberg, C, Brooijmans, G, Brooke, J, Bross, A, Brunetti, G, Buchanan, N, Budd, H, Caiulo, D, Calafiura, P, Calcutt, J, Calin, M, Calvez, S, Calvo, E, Camilleri, L, Caminata, A, Campanelli, M, Caratelli, D, Carini, G, Carlus, B, Carniti, P, Terrazas, I, Carranza, H, Castillo, A, Castromonte, C, Cattadori, C, Cavalier, F, Cavanna, F, Centro, S, Cerati, G, Cervelli, A, Villanueva, A, Chalifour, M, Chang, C, Chardonnet, E, Chatterjee, A, Chattopadhyay, S, Chaves, J, Chen, H, Chen, M, Chen, Y, Cherdack, D, Chi, C, Childress, S, Chiriacescu, A, Cho, K, Choubey, S, Christensen, A, Christian, D, Christodoulou, G, Church, E, Clarke, P, Coan, T, Cocco, A, Coelho, J, Conley, E, Conrad, J, Convery, M, Corwin, L, Cotte, P, Cremaldi, L, Cremonesi, L, Crespo-Anadon, J, Cristaldo, E, Cross, R, Cuesta, C, Cui, Y, Cussans, D, Dabrowski, M, Motta, H, Peres, L, David, Q, Davies, G, Davini, S, Dawson, J, De, K, Almeida, R, Debbins, P, Bonis, I, Decowski, M, Gouvea, A, Holanda, P, Astiz, I, Deisting, A, Jong, P, Delbart, A, Delepine, D, Delgado, M, Dell'Acqua, A, Lurgio, P, Neto, J, Demuth, D, Dennis, S, Densham, C, Deptuch, G, Roeck, A, Romeri, V, Vries, J, Dharmapalan, R, Dias, M, Diaz, F, Diaz, J, Domizio, S, Giulio, L, Ding, P, Noto, L, Distefano, C, Diurba, R, Diwan, M, Djurcic, Z, Dokania, N, Dolinski, M, Domine, L, Douglas, D, Drielsma, F, Duchesneau, D, Duffy, K, Dunne, P, Durkin, T, Duyang, H, Dvornikov, O, Dwyer, D, Dyshkant, A, Eads, M, Edmunds, D, Eisch, J, Emery, S, Ereditato, A, Escobar, C, Sanchez, L, Evans, J, Ewart, E, Ezeribe, A, Fahey, K, Falcone, A, Farnese, C, Farzan, Y, Felix, J, Fernandez-Martinez, E, Menendez, P, Ferraro, F, Fields, L, Filkins, A, Filthaut, F, Fitzpatrick, R, Flanagan, W, Fleming, B, Flight, R, Fowler, J, Fox, W, Franc, J, Francis, K, Franco, D, Freeman, J, Freestone, J, Fried, J, Friedland, A, Fuess, S, Furic, I, Furmanski, A, Gago, A, Gallagher, H, Gallego-Ros, A, Gallice, N, Galymov, V, Gamberini, E, Gamble, T, Gandhi, R, Gandrajula, R, Gao, S, Garcia-Gamez, D, Garcia-Peris, M, Gardiner, S, Gastler, D, Ge, G, Gelli, B, Gendotti, A, Gent, S, Ghorbani-Moghaddam, Z, Gibin, D, Gil-Botella, I, Girerd, C, Giri, A, Gnani, D, Gogota, O, Gold, M, Gollapinni, S, Gollwitzer, K, Gomes, R, Bermeo, L, Fajardo, L, Gonnella, F, Gonzalez-Cuevas, J, Goodman, M, Goodwin, O, Goswami, S, Gotti, C, Goudzovski, E, Grace, C, Graham, M, Gramellini, E, Gran, R, Granados, E, Grant, A, Grant, C, Gratieri, D, Green, P, Green, S, Greenler, L, Greenwood, M, Greer, J, Griffith, C, Groh, M, Grudzinski, J, Grzelak, K, Gu, W, Guarino, V, Guenette, R, Guglielmi, A, Guo, B, Guthikonda, K, Gutierrez, R, Guzowski, P, Guzzo, M, Gwon, S, Habig, A, Hackenburg, A, Hadavand, H, Haenni, R, Hahn, A, Haigh, J, Haiston, J, Hamernik, T, Hamilton, P, Han, J, Harder, K, Harris, D, Hartnell, J, Hasegawa, T, Hatcher, R, Hazen, E, Heavey, A, Heeger, K, Hennessy, K, Henry, S, Morquecho, M, Herner, K, Hertel, L, Hesam, A, Hewes, J, Pichardo, A, Hill, T, Hillier, S, Himmel, A, Hoff, J, Hohl, C, Holin, A, Hoppe, E, Horton-Smith, G, Hostert, M, Hourlier, A, Howard, B, Howell, R, Huang, J, Hugon, J, Iles, G, Iliescu, A, Illingworth, R, Ioannisian, A, Itay, R, Izmaylov, A, James, E, Jargowsky, B, Jediny, F, Jesus-Valls, C, Ji, X, Jiang, L, Jimenez, S, Jipa, A, Joglekar, A, Johnson, C, Johnson, R, Jones, B, Jones, S, Jung, C, Junk, T, Jwa, Y, Kabirnezhad, M, Kaboth, A, Kadenko, I, Kamiya, F, Karagiorgi, G, Karcher, A, Karolak, M, Karyotakis, Y, Kasai, S, Kasetti, S, Kashur, L, Kazaryan, N, Kearns, E, Keener, P, Kelly, K, Kemp, E, Ketchum, W, Kettell, S, Khabibullin, M, Khotjantsev, A, Khvedelidze, A, Kim, D, King, B, Kirby, B, Kirby, M, Klein, J, Koehler, K, Koerner, L, Kohn, S, Koller, P, Kordosky, M, Kosc, T, Kose, U, Kostelecky, V, Kothekar, K, Krennrich, F, Kreslo, I, Kudenko, Y, Kudryavtsev, V, Kulagin, S, Kumar, J, Kumar, R, Kuruppu, C, Kus, V, Kutter, T, Lambert, A, Lande, K, Lane, C, Lang, K, Langford, T, Lasorak, P, Last, D, Lastoria, C, Laundrie, A, Lawrence, A, Lazanu, I, Lazur, R, Le, T, Learned, J, Lebrun, P, Miotto, G, Lehnert, R, De Oliveira, M, Leitner, M, Leyton, M, Li, L, Li, S, Li, T, Li, Y, Liao, H, Lin, C, Lin, S, Lister, A, Littlejohn, B, Liu, J, Lockwitz, S, Loew, T, Lokajicek, M, Lomidze, I, Long, K, Loo, K, Lorca, D, Lord, T, Losecco, J, Louis, W, Luk, K, Luo, X, Lurkin, N, Lux, T, Luzio, V, Macfarland, D, Machado, A, Machado, P, Macias, C, Macier, J, Maddalena, A, Madigan, P, Magill, S, Mahn, K, Maio, A, Maloney, J, Mandrioli, G, Maneira, J, Manenti, L, Manly, S, Mann, A, Manolopoulos, K, Plata, M, Marchionni, A, Marciano, W, Marfatia, D, Mariani, C, Maricic, J, Marinho, F, Marino, A, Marshak, M, Marshall, C, Marshall, J, Marteau, J, Martin-Albo, J, Martinez, N, Caicedo, D, Martynenko, S, Mason, K, Mastbaum, A, Masud, M, Matsuno, S, Matthews, J, Mauger, C, Mauri, N, Mavrokoridis, K, Mazza, R, Mazzacane, A, Mazzucato, E, Mccluskey, E, Mcconkey, N, Mcfarland, K, Mcgrew, C, Mcnab, A, Mefodiev, A, Mehta, P, Melas, P, Mellinato, M, Mena, O, Menary, S, Mendez, H, Menegolli, A, Meng, G, Messier, M, Metcalf, W, Mewes, M, Meyer, H, Miao, T, Michna, G, Miedema, T, Migenda, J, Milincic, R, Miller, W, Mills, J, Milne, C, Mineev, O, Miranda, O, Miryala, S, Mishra, C, Mishra, S, Mislivec, A, Mladenov, D, Mocioiu, I, Moffat, K, Moggi, N, Mohanta, R, Mohayai, T, Mokhov, N, Molina, J, Bueno, L, Montanari, A, Montanari, C, Montanari, D, Zetina, L, Moon, J, Mooney, M, Moor, A, Moreno, D, Morgan, B, Morris, C, Mossey, C, Motuk, E, Moura, C, Mousseau, J, Mu, W, Mualem, L, Mueller, J, Muether, M, Mufson, S, Muheim, F, Muir, A, Mulhearn, M, Muramatsu, H, Murphy, S, Musser, J, Nachtman, J, Nagu, S, 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A., Adamov, G., Adams, D., Adinolfi, M., Ahmad, Z., Ahmed, J., Alion, T., Monsalve, S. Alonso, Alt, C., Anderson, J., Andreopoulos, C., Andrews, M., Andrianala, F., Andringa, S., Ankowski, A., Antonova, M., Antusch, S., Aranda-Fernandez, A., Ariga, A., Arnold, L. O., Arroyave, M. A., Asaadi, J., Aurisano, A., Aushev, V., Autiero, D., Azfar, F., Back, H., Back, J. J., Backhouse, C., Baesso, P., Bagby, L., Bajou, R., Balasubramanian, S., Baldi, P., Bambah, B., Barao, F., Barenboim, G., Barker, G., Barkhouse, W., Barnes, C., Barr, G., Monarca, J. Barranco, Barros, N., Barrow, J. L., Bashyal, A., Basque, V., Bay, F., Alba, J. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Belver, D., Benekos, N., Neves, F. Bento, Berger, J., Berkman, S., Bernardini, P., Berner, R. 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Cervera, Chalifour, M., Chang, C., Chardonnet, E., Chatterjee, A., Chattopadhyay, S., Chaves, J., Chen, H., Chen, M., Chen, Y., Cherdack, D., Chi, C., Childress, S., Chiriacescu, A., Cho, K., Choubey, S., Christensen, A., Christian, D., Christodoulou, G., Church, E., Clarke, P., Coan, T. E., Cocco, A. G., Coelho, J., Conley, E., Conrad, J., Convery, M., Corwin, L., Cotte, P., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Cristaldo, E., Cross, R., Cuesta, C., Cui, Y., Cussans, D., Dabrowski, M., Motta, H. Da, Peres, L. Da Silva, David, Q., Davies, G. S., Davini, S., Dawson, J., De, K., Almeida, R. M. De, Debbins, P., Bonis, I. De, Decowski, M., Gouvea, A. De, Holanda, P. C. De, Astiz, I. L. De Icaza, Deisting, A., Jong, P. De, Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., Lurgio, P. De, Neto, J. R. De Mello, Demuth, D. M., Dennis, S., Densham, C., Deptuch, G., Roeck, A. De, Romeri, V. De, Vries, J. De, Dharmapalan, R., Dias, M., Diaz, F., Diaz, J., Domizio, S. Di, Giulio, L. Di, Ding, P., Noto, L. Di, Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Dokania, N., Dolinski, M., Domine, L., Douglas, D., Drielsma, F., Duchesneau, D., Duffy, K., Dunne, P., Durkin, T., Duyang, H., Dvornikov, O., Dwyer, D., Dyshkant, A., Eads, M., Edmunds, D., Eisch, J., Emery, S., Ereditato, A., Escobar, C., Sanchez, L. Escudero, Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Falcone, A., Farnese, C., Farzan, Y., Felix, J., Fernandez-Martinez, E., Menendez, P. Fernandez, Ferraro, F., Fields, L., Filkins, A., Filthaut, F., Fitzpatrick, R. S., Flanagan, W., Fleming, B., Flight, R., Fowler, J., Fox, W., Franc, J., Francis, K., Franco, D., Freeman, J., Freestone, J., Fried, J., Friedland, A., Fuess, S., Furic, I., Furmanski, A. P., Gago, A., Gallagher, H., Gallego-Ros, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Gandhi, R., Gandrajula, R., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardiner, S., Gastler, D., Ge, G., Gelli, B., Gendotti, A., Gent, S., Ghorbani-Moghaddam, Z., Gibin, D., Gil-Botella, I., Girerd, C., Giri, A., Gnani, D., Gogota, O., Gold, M., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. Gomez, Fajardo, L. S. Gomez, Gonnella, F., Gonzalez-Cuevas, J., Goodman, M. C., Goodwin, O., Goswami, S., Gotti, C., Goudzovski, E., Grace, C., Graham, M., Gramellini, E., Gran, R., Granados, E., Grant, A., Grant, C., Gratieri, D., Green, P., Green, S., Greenler, L., Greenwood, M., Greer, J., Griffith, C., Groh, M., Grudzinski, J., Grzelak, K., Gu, W., Guarino, V., Guenette, R., Guglielmi, A., Guo, B., Guthikonda, K., Gutierrez, R., Guzowski, P., Guzzo, M. M., Gwon, S., Habig, A., Hackenburg, A., Hadavand, H., Haenni, R., Hahn, A., Haigh, J., Haiston, J., Hamernik, T., Hamilton, P., Han, J., Harder, K., Harris, D. A., Hartnell, J., Hasegawa, T., Hatcher, R., Hazen, E., Heavey, A., Heeger, K. M., Hennessy, K., Henry, S., Morquecho, M. Hernandez, Herner, K., Hertel, L., Hesam, A. S., Hewes, J., Pichardo, A. Higuera, Hill, T., Hillier, S. J., Himmel, A., Hoff, J., Hohl, C., Holin, A., Hoppe, E., Horton-Smith, G. A., Hostert, M., Hourlier, A., Howard, B., Howell, R., Huang, J., Hugon, J., Iles, G., Iliescu, A. M., Illingworth, R., Ioannisian, A., Itay, R., Izmaylov, A., James, E., Jargowsky, B., Jediny, F., Jesús-Valls, C., Ji, X., Jiang, L., Jiménez, S., Jipa, A., Joglekar, A., Johnson, C., Johnson, R., Jones, B., Jones, S., Jung, C., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A., Kadenko, I., Kamiya, F., Karagiorgi, G., Karcher, A., Karolak, M., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Kazaryan, N., Kearns, E., Keener, P., Kelly, K. J., Kemp, E., Ketchum, W., Kettell, S., Khabibullin, M., Khotjantsev, A., Khvedelidze, A., Kim, D., King, B., Kirby, B., Kirby, M., Klein, J., Koehler, K., Koerner, L. W., Kohn, S., Koller, P. P., Kordosky, M., Kosc, T., Kose, U., Kostelecky, V., Kothekar, K., Krennrich, F., Kreslo, I., Kudenko, Y., Kudryavtsev, V., Kulagin, S., Kumar, J., Kumar, R., Kuruppu, C., Kus, V., Kutter, T., Lambert, A., Lande, K., Lane, C. E., Lang, K., Langford, T., Lasorak, P., Last, D., Lastoria, C., Laundrie, A., Lawrence, A., Lazanu, I., Lazur, R., Le, T., Learned, J., Lebrun, P., Miotto, G. Lehmann, Lehnert, R., de Oliveira, M. Leigui, Leitner, M., Leyton, M., Li, L., Li, S., Li, T., Li, Y., Liao, H., Lin, C., Lin, S., Lister, A., Littlejohn, B. R., Liu, J., Lockwitz, S., Loew, T., Lokajicek, M., Lomidze, I., Long, K., Loo, K., Lorca, D., Lord, T., Losecco, J., Louis, W. C., Luk, K., Luo, X., Lurkin, N., Lux, T., Luzio, V. P., Macfarland, D., Machado, A., Machado, P., Macias, C., Macier, J., Maddalena, A., Madigan, P., Magill, S., Mahn, K., Maio, A., Maloney, J. A., Mandrioli, G., Maneira, J. C., Manenti, L., Manly, S., Mann, A., Manolopoulos, K., Plata, M. Manrique, Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marinho, F., Marino, A. D., Marshak, M., Marshall, C., Marshall, J., Marteau, J., Martin-Albo, J., Martinez, N., Caicedo, D. A. Martinez, Martynenko, S., Mason, K., Mastbaum, A., Masud, M., Matsuno, S., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mazza, R., Mazzacane, A., Mazzucato, E., Mccluskey, E., Mcconkey, N., Mcfarland, K. S., Mcgrew, C., Mcnab, A., Mefodiev, A., Mehta, P., Melas, P., Mellinato, M., Mena, O., Menary, S., Mendez, H., Menegolli, A., Meng, G., Messier, M., Metcalf, W., Mewes, M., Meyer, H., Miao, T., Michna, G., Miedema, T., Migenda, J., Milincic, R., Miller, W., Mills, J., Milne, C., Mineev, O., Miranda, O. G., Miryala, S., Mishra, C., Mishra, S., Mislivec, A., Mladenov, D., Mocioiu, I., Moffat, K., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J. A., Bueno, L. Molina, Montanari, A., Montanari, C., Montanari, D., Zetina, L. M. Montano, Moon, J., Mooney, M., Moor, A., Moreno, D., Morgan, B., Morris, C., Mossey, C., Motuk, E., Moura, C. A., Mousseau, J., Mu, W., Mualem, L., Mueller, J., Muether, M., Mufson, S., Muheim, F., Muir, A., Mulhearn, M., Muramatsu, H., Murphy, S., Musser, J., Nachtman, J., Nagu, S., Nalbandyan, M., Nandakumar, R., Naples, D., Narita, S., Navas-Nicolás, D., Nayak, N., Nebot-Guinot, M., Necib, L., Negishi, K., Nelson, J. K., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Newhart, D., Nichol, R., Niner, E., Nishimura, K., Norman, A., Northrop, R., Novella, P., Nowak, J. A., Oberling, M., Campo, A. Olivares Del, Olivier, A., Onel, Y., Onishchuk, Y., Ott, J., Pagani, L., Pakvasa, S., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Pantic, E., Paolone, V., Papadimitriou, V., Papaleo, R., Papanestis, A., Paramesvaran, S., Parke, S., Parsa, Z., Parvu, M., Pascoli, S., Pasqualini, L., Pasternak, J., Pater, J., Patrick, C., Patrizii, L., Patterson, R. B., Patton, S., Patzak, T., Paudel, A., Paulos, B., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Peeters, S. J., Penichot, Y., Pennacchio, E., Penzo, A., Peres, O. L., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Piastra, F., Pickering, L., Pietropaolo, F., Pillow, J., Plunkett, R., Poling, R., Pons, X., Poonthottathil, N., Pordes, S., Potekhin, M., Potenza, R., Potukuchi, B. V., Pozimski, J., Pozzato, M., Prakash, S., Prakash, T., Prince, S., Prior, G., Pugnere, D., Qi, K., Qian, X., Raaf, J., Raboanary, R., Radeka, V., Rademacker, J., Radics, B., Rafique, A., Raguzin, E., Rai, M., Rajaoalisoa, M., Rakhno, I., Rakotondramanana, H., Rakotondravohitra, L., Ramachers, Y., Rameika, R., Delgado, M. Ramirez, Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Ravat, S., Razafinime, H., Real, J., Rebel, B., Redondo, D., Reggiani-Guzzo, M., Rehak, T., Reichenbacher, J., Reitzner, S. D., Renshaw, A., Rescia, S., Resnati, F., Reynolds, A., Riccobene, G., Rice, L. C., Rielage, K., Rigaut, Y., Rivera, D., Rochester, L., Roda, M., Rodrigues, P., Alonso, M. Rodriguez, Rondon, J. Rodriguez, Roeth, A., Rogers, H., Rosauro-Alcaraz, S., Rossella, M., Rout, J., Roy, S., Rubbia, A., Rubbia, C., Russell, B., Russell, J., Ruterbories, D., Saakyan, R., Sacerdoti, S., Safford, T., Sahu, N., Sala, P., Samios, N., Sanchez, M., Sanders, D. A., Sankey, D., Santana, S., Santos-Maldonado, M., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Savage, G., Savinov, V., Scaramelli, A., Scarff, A., Scarpelli, A., Schaffer, T., Schellman, H., Schlabach, P., Schmitz, D., Scholberg, K., Schukraft, A., Segreto, E., Sensenig, J., Seong, I., Sergi, A., Sergiampietri, F., Sgalaberna, D., Shaevitz, M., Shafaq, S., Shamma, M., Sharma, H. R., Sharma, R., Shaw, T., Shepherd-Themistocleous, C., Shin, S., Shooltz, D., Shrock, R., Simard, L., Simos, N., Sinclair, J., Sinev, G., Singh, J., Singh, V., Sipos, R., Sippach, F., Sirri, G., Sitraka, A., Siyeon, K., Smargianaki, D., Smith, A., Smith, E., Smith, P., Smolik, J., Smy, M., Snopok, P., Nunes, M. Soare, Sobel, H., Soderberg, M., Salinas, C. J. Solano, Söldner-Rembold, S., Solomey, N., Solovov, V., Sondheim, W. E., Sorel, M., Soto-Oton, J., Sousa, A., Soustruznik, K., Spagliardi, F., Spanu, M., Spitz, J., Spooner, N. J., Spurgeon, K., Staley, R., Stancari, M., Stanco, L., Steiner, H., Stewart, J., Stillwell, B., Stock, J., Stocker, F., Stokes, T., Strait, M., Strauss, T., Striganov, S., Stuart, A., Summers, D., Surdo, A., Susic, V., Suter, L., Sutera, C., Svoboda, R., Szczerbinska, B., Szelc, A., Talaga, R., Tanaka, H., Oregui, B. Tapia, Tapper, A., Tariq, S., Tatar, E., Tayloe, R., Teklu, A., Tenti, M., Terao, K., Ternes, C. A., Terranova, F., Testera, G., Thea, A., Thompson, J. L., Thorn, C., Timm, S., Tonazzo, A., Torti, M., Tortola, M., Tortorici, F., Totani, D., Toups, M., Touramanis, C., Trevor, J., Trzaska, W. H., Tsai, Y. T., Tsamalaidze, Z., Tsang, K., Tsverava, N., Tufanli, S., Tull, C., Tyley, E., Tzanov, M., Uchida, M. A., Urheim, J., Usher, T., Vagins, M., Vahle, P., Valdiviesso, G., Valencia, E., Vallari, Z., Valle, J. W., Vallecorsa, S., Berg, R. Van, de Water, R. G. Van, Forero, D. Vanega, Varanini, F., Vargas, D., Varner, G., Vasel, J., Vasseur, G., Vaziri, K., Ventura, S., Verdugo, A., Vergani, S., Vermeulen, M. A., Verzocchi, M., de Souza, H. Vieira, Vignoli, C., Vilela, C., Viren, B., Vrba, T., Wachala, T., Waldron, A. V., Wallbank, M., Wang, H., Wang, J., Wang, Y., Warburton, K., Warner, D., Wascko, M., Waters, D., Watson, A., Weatherly, P., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenman, D., Wetstein, M., While, M. R., White, A., Whitehead, L. H., Whittington, D., Wilking, M. J., Wilkinson, C., Williams, Z., Wilson, F., Wilson, R. J., Wolcott, J., Wongjirad, T., Wood, K., Wood, L., Worcester, E., Worcester, M., Wret, C., Wu, W., Xiao, Y., Yang, G., Yang, T., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, J., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G., Zennamo, J., Zeug, K., Zhang, C., Zhao, M., Zhivun, E., Zhu, G., Zimmerman, E. D., Zito, M., Zucchelli, S., Zuklin, J., Zutshi, V., Zwaska, R., Abi B., Acciarri R., Acero M.A., Adamov G., Adams D., Adinolfi M., Ahmad Z., Ahmed J., Alion T., Monsalve S.A., Alt C., Anderson J., Andreopoulos C., Andrews M., Andrianala F., Andringa S., Ankowski A., Antonova M., Antusch S., Aranda-Fernandez A., Ariga A., Arnold L.O., Arroyave M.A., Asaadi J., Aurisano A., Aushev V., Autiero D., Azfar F., Back H., Back J.J., Backhouse C., Baesso P., Bagby L., Bajou R., Balasubramanian S., Baldi P., Bambah B., Barao F., Barenboim G., Barker G., Barkhouse W., Barnes C., Barr G., Monarca J.B., Barros N., Barrow J.L., Bashyal A., Basque V., Bay F., Alba J.B., Beacom J.F., Bechetoille E., Behera B., Bellantoni L., Bellettini G., Bellini V., Beltramello O., Belver D., Benekos N., Neves F.B., Berger J., Berkman S., Bernardini P., Berner R.M., Berns H., Bertolucci S., Betancourt M., Bezawada Y., Bhattacharjee M., Bhuyan B., Biagi S., Bian J., Biassoni M., Biery K., Bilki B., Bishai M., Bitadze A., Blake A., Siffert B.B., Blaszczyk F., Blazey G., Blucher E., Boissevain J., Bolognesi S., Bolton T., Bonesini M., Bongrand M., Bonini F., Booth A., Booth C., Bordoni S., Borkum A., Boschi T., Bostan N., Bour P., Boyd S., Boyden D., Bracinik J., Braga D., Brailsford D., Brandt A., Bremer J., Brew C., Brianne E., Brice S.J., Brizzolari C., Bromberg C., Brooijmans G., Brooke J., Bross A., Brunetti G., Buchanan N., Budd H., Caiulo D., Calafiura P., Calcutt J., Calin M., Calvez S., Calvo E., Camilleri L., Caminata A., Campanelli M., Caratelli D., Carini G., Carlus B., Carniti P., Terrazas I.C., Carranza H., Castillo A., Castromonte C., Cattadori C., Cavalier F., Cavanna F., Centro S., Cerati G., Cervelli A., Villanueva A.C., Chalifour M., Chang C., Chardonnet E., Chatterjee A., Chattopadhyay S., Chaves J., Chen H., Chen M., Chen Y., Cherdack D., Chi C., Childress S., Chiriacescu A., Cho K., Choubey S., Christensen A., Christian D., Christodoulou G., Church E., Clarke P., Coan T.E., Cocco A.G., Coelho J., Conley E., Conrad J., Convery M., Corwin L., Cotte P., Cremaldi L., Cremonesi L., Crespo-Anadon J.I., Cristaldo E., Cross R., Cuesta C., Cui Y., Cussans D., Dabrowski M., Motta H.D., Peres L.D.S., David Q., Davies G.S., Davini S., Dawson J., De K., Almeida R.M.D., Debbins P., Bonis I.D., Decowski M., Gouvea A.D., Holanda P.C.D., Astiz I.L.D.I., Deisting A., Jong P.D., Delbart A., Delepine D., Delgado M., Dell'acqua A., Lurgio P.D., Neto J.R.D.M., Demuth D.M., Dennis S., Densham C., Deptuch G., Roeck A.D., Romeri V.D., Vries J.D., Dharmapalan R., Dias M., Diaz F., Diaz J., Domizio S.D., Giulio L.D., Ding P., Noto L.D., Distefano C., Diurba R., Diwan M., Djurcic Z., Dokania N., Dolinski M., Domine L., Douglas D., Drielsma F., Duchesneau D., Duffy K., Dunne P., Durkin T., Duyang H., Dvornikov O., Dwyer D., Dyshkant A., Eads M., Edmunds D., Eisch J., Emery S., Ereditato A., Escobar C., Sanchez L.E., Evans J.J., Ewart E., Ezeribe A.C., Fahey K., Falcone A., Farnese C., Farzan Y., Felix J., Fernandez-Martinez E., Menendez P.F., Ferraro F., Fields L., Filkins A., Filthaut F., Fitzpatrick R.S., Flanagan W., Fleming B., Flight R., Fowler J., Fox W., Franc J., Francis K., Franco D., Freeman J., Freestone J., Fried J., Friedland A., Fuess S., Furic I., Furmanski A.P., Gago A., Gallagher H., Gallego-Ros A., Gallice N., Galymov V., Gamberini E., Gamble T., Gandhi R., Gandrajula R., Gao S., Garcia-Gamez D., Garcia-Peris M.A., Gardiner S., Gastler D., Ge G., Gelli B., Gendotti A., Gent S., Ghorbani-Moghaddam Z., Gibin D., Gil-Botella I., Girerd C., Giri A., Gnani D., Gogota O., Gold M., Gollapinni S., Gollwitzer K., Gomes R.A., Bermeo L.G., Fajardo L.S.G., Gonnella F., Gonzalez-Cuevas J., Goodman M.C., Goodwin O., Goswami S., Gotti C., Goudzovski E., Grace C., Graham M., Gramellini E., Gran R., Granados E., Grant A., Grant C., Gratieri D., Green P., Green S., Greenler L., Greenwood M., Greer J., Griffith C., Groh M., Grudzinski J., Grzelak K., Gu W., Guarino V., Guenette R., Guglielmi A., Guo B., Guthikonda K., Gutierrez R., Guzowski P., Guzzo M.M., Gwon S., Habig A., Hackenburg A., Hadavand H., Haenni R., Hahn A., Haigh J., Haiston J., Hamernik T., Hamilton P., Han J., Harder K., Harris D.A., Hartnell J., Hasegawa T., Hatcher R., Hazen E., Heavey A., Heeger K.M., Hennessy K., Henry S., Morquecho M.H., Herner K., Hertel L., Hesam A.S., Hewes J., Pichardo A.H., Hill T., Hillier S.J., Himmel A., Hoff J., Hohl C., Holin A., Hoppe E., Horton-Smith G.A., Hostert M., Hourlier A., Howard B., Howell R., Huang J., Hugon J., Iles G., Iliescu A.M., Illingworth R., Ioannisian A., Itay R., Izmaylov A., James E., Jargowsky B., Jediny F., Jesus-Valls C., Ji X., Jiang L., Jimenez S., Jipa A., Joglekar A., Johnson C., Johnson R., Jones B., Jones S., Jung C., Junk T., Jwa Y., Kabirnezhad M., Kaboth A., Kadenko I., Kamiya F., Karagiorgi G., Karcher A., Karolak M., Karyotakis Y., Kasai S., Kasetti S.P., Kashur L., Kazaryan N., Kearns E., Keener P., Kelly K.J., Kemp E., Ketchum W., Kettell S., Khabibullin M., Khotjantsev A., Khvedelidze A., Kim D., King B., Kirby B., Kirby M., Klein J., Koehler K., Koerner L.W., Kohn S., Koller P.P., Kordosky M., Kosc T., Kose U., Kostelecky V., Kothekar K., Krennrich F., Kreslo I., Kudenko Y., Kudryavtsev V., Kulagin S., Kumar J., Kumar R., Kuruppu C., Kus V., Kutter T., Lambert A., Lande K., Lane C.E., Lang K., Langford T., Lasorak P., Last D., Lastoria C., Laundrie A., Lawrence A., Lazanu I., Lazur R., Le T., Learned J., Lebrun P., Miotto G.L., Lehnert R., De Oliveira M.L., Leitner M., Leyton M., Li L., Li S., Li T., Li Y., Liao H., Lin C., Lin S., Lister A., Littlejohn B.R., Liu J., Lockwitz S., Loew T., Lokajicek M., Lomidze I., Long K., Loo K., Lorca D., Lord T., Losecco J., Louis W.C., Luk K., Luo X., Lurkin N., Lux T., Luzio V.P., MacFarland D., MacHado A., MacHado P., MacIas C., MacIer J., Maddalena A., Madigan P., Magill S., Mahn K., Maio A., Maloney J.A., Mandrioli G., Maneira J.C., Manenti L., Manly S., Mann A., Manolopoulos K., Plata M.M., Marchionni A., Marciano W., Marfatia D., Mariani C., Maricic J., Marinho F., Marino A.D., Marshak M., Marshall C., Marshall J., Marteau J., Martin-Albo J., Martinez N., Caicedo D.A.M., Martynenko S., Mason K., Mastbaum A., Masud M., Matsuno S., Matthews J., Mauger C., Mauri N., Mavrokoridis K., Mazza R., Mazzacane A., Mazzucato E., McCluskey E., McConkey N., McFarland K.S., McGrew C., McNab A., Mefodiev A., Mehta P., Melas P., Mellinato M., Mena O., Menary S., Mendez H., Menegolli A., Meng G., Messier M., Metcalf W., Mewes M., Meyer H., Miao T., Michna G., Miedema T., Migenda J., Milincic R., Miller W., Mills J., Milne C., Mineev O., Miranda O.G., Miryala S., Mishra C., Mishra S., Mislivec A., Mladenov D., Mocioiu I., Moffat K., Moggi N., Mohanta R., Mohayai T.A., Mokhov N., Molina J.A., Bueno L.M., Montanari A., Montanari C., Montanari D., Zetina L.M.M., Moon J., Mooney M., Moor A., Moreno D., Morgan B., Morris C., Mossey C., Motuk E., Moura C.A., Mousseau J., Mu W., Mualem L., Mueller J., Muether M., Mufson S., Muheim F., Muir A., Mulhearn M., Muramatsu H., Murphy S., Musser J., Nachtman J., Nagu S., Nalbandyan M., Nandakumar R., Naples D., Narita S., Navas-Nicolas D., Nayak N., Nebot-Guinot M., Necib L., Negishi K., Nelson J.K., Nesbit J., Nessi M., Newbold D., Newcomer M., Newhart D., Nichol R., Niner E., Nishimura K., Norman A., Northrop R., Novella P., Nowak J.A., Oberling M., Campo A.O.D., Olivier A., Onel Y., Onishchuk Y., Ott J., Pagani L., Pakvasa S., Palamara O., Palestini S., Paley J.M., Pallavicini M., Palomares C., Pantic E., Paolone V., Papadimitriou V., Papaleo R., Papanestis A., Paramesvaran S., Parke S., Parsa Z., Parvu M., Pascoli S., Pasqualini L., Pasternak J., Pater J., Patrick C., Patrizii L., Patterson R.B., Patton S., Patzak T., Paudel A., Paulos B., Paulucci L., Pavlovic Z., Pawloski G., Payne D., Pec V., Peeters S.J., Penichot Y., Pennacchio E., Penzo A., Peres O.L., Perry J., Pershey D., Pessina G., Petrillo G., Petta C., Petti R., Piastra F., Pickering L., Pietropaolo F., Pillow J., Plunkett R., Poling R., Pons X., Poonthottathil N., Pordes S., Potekhin M., Potenza R., Potukuchi B.V., Pozimski J., Pozzato M., Prakash S., Prakash T., Prince S., Prior G., Pugnere D., Qi K., Qian X., Raaf J., Raboanary R., Radeka V., Rademacker J., Radics B., Rafique A., Raguzin E., Rai M., Rajaoalisoa M., Rakhno I., Rakotondramanana H., Rakotondravohitra L., Ramachers Y., Rameika R., Delgado M.R., Ramson B., Rappoldi A., Raselli G., Ratoff P., Ravat S., Razafinime H., Real J., Rebel B., Redondo D., Reggiani-Guzzo M., Rehak T., Reichenbacher J., Reitzner S.D., Renshaw A., Rescia S., Resnati F., Reynolds A., Riccobene G., Rice L.C., Rielage K., Rigaut Y., Rivera D., Rochester L., Roda M., Rodrigues P., Alonso M.R., Rondon J.R., Roeth A., Rogers H., Rosauro-Alcaraz S., Rossella M., Rout J., Roy S., Rubbia A., Rubbia C., Russell B., Russell J., Ruterbories D., Saakyan R., Sacerdoti S., Safford T., Sahu N., Sala P., Samios N., Sanchez M., Sanders D.A., Sankey D., Santana S., Santos-Maldonado M., Saoulidou N., Sapienza P., Sarasty C., Sarcevic I., Savage G., Savinov V., Scaramelli A., Scarff A., Scarpelli A., Schaffer T., Schellman H., Schlabach P., Schmitz D., Scholberg K., Schukraft A., Segreto E., Sensenig J., Seong I., Sergi A., Sergiampietri F., Sgalaberna D., Shaevitz M., Shafaq S., Shamma M., Sharma H.R., Sharma R., Shaw T., Shepherd-Themistocleous C., Shin S., Shooltz D., Shrock R., Simard L., Simos N., Sinclair J., Sinev G., Singh J., Singh V., Sipos R., Sippach F., Sirri G., Sitraka A., Siyeon K., Smargianaki D., Smith A., Smith E., Smith P., Smolik J., Smy M., Snopok P., Nunes M.S., Sobel H., Soderberg M., Salinas C.J.S., Soldner-Rembold S., Solomey N., Solovov V., Sondheim W.E., Sorel M., Soto-Oton J., Sousa A., Soustruznik K., Spagliardi F., Spanu M., Spitz J., Spooner N.J., Spurgeon K., Staley R., Stancari M., Stanco L., Steiner H., Stewart J., Stillwell B., Stock J., Stocker F., Stokes T., Strait M., Strauss T., Striganov S., Stuart A., Summers D., Surdo A., Susic V., Suter L., Sutera C., Svoboda R., Szczerbinska B., Szelc A., Talaga R., Tanaka H., Oregui B.T., Tapper A., Tariq S., Tatar E., Tayloe R., Teklu A., Tenti M., Terao K., Ternes C.A., Terranova F., Testera G., Thea A., Thompson J.L., Thorn C., Timm S., Tonazzo A., Torti M., Tortola M., Tortorici F., Totani D., Toups M., Touramanis C., Trevor J., Trzaska W.H., Tsai Y.T., Tsamalaidze Z., Tsang K., Tsverava N., Tufanli S., Tull C., Tyley E., Tzanov M., Uchida M.A., Urheim J., Usher T., Vagins M., Vahle P., Valdiviesso G., Valencia E., Vallari Z., Valle J.W., Vallecorsa S., Berg R.V., De Water R.G.V., Forero D.V., Varanini F., Vargas D., Varner G., Vasel J., Vasseur G., Vaziri K., Ventura S., Verdugo A., Vergani S., Vermeulen M.A., Verzocchi M., De Souza H.V., Vignoli C., Vilela C., Viren B., Vrba T., Wachala T., Waldron A.V., Wallbank M., Wang H., Wang J., Wang Y., Warburton K., Warner D., Wascko M., Waters D., Watson A., Weatherly P., Weber A., Weber M., Wei H., Weinstein A., Wenman D., Wetstein M., While M.R., White A., Whitehead L.H., Whittington D., Wilking M.J., Wilkinson C., Williams Z., Wilson F., Wilson R.J., Wolcott J., Wongjirad T., Wood K., Wood L., Worcester E., Worcester M., Wret C., Wu W., Xiao Y., Yang G., Yang T., Yershov N., Yonehara K., Young T., Yu B., Yu J., Zalesak J., Zambelli L., Zamorano B., Zani A., Zazueta L., Zeller G., Zennamo J., Zeug K., Zhang C., Zhao M., Zhivun E., Zhu G., Zimmerman E.D., Zito M., Zucchelli S., Zuklin J., Zutshi V., and Zwaska R.

Subjects
Technology, 530 Physics, media_common.quotation_subject, Neutrino oscillations, liquid Argon TPC, DUNE technical design report, single phase LArTPC, Electrons, FREE-ELECTRONS, 01 natural sciences, 7. Clean energy, 09 Engineering, 030218 nuclear medicine & medical imaging, Standard Model, 03 medical and health sciences, neutrino, 0302 clinical medicine, LIQUID ARGON, 0103 physical sciences, Grand Unified Theory, High Energy Physics, Aerospace engineering, Instrumentation, Instruments & Instrumentation, Mathematical Physics, media_common, Physics, Science & Technology, 02 Physical Sciences, 010308 nuclear & particles physics, business.industry, Detector, Lıquıd Argonfree, Nuclear & Particles Physics, Symmetry (physics), Universe, Long baseline neutrino experiment, CP violation, Antimatter, Neutrino, business, Event (particle physics)
Abstract

This document was prepared by the DUNE collaboration using the resources of the Fermi National Accelerator Laboratory (Fermilab), a U.S. Department of Energy, Office of Science, HEP User Facility. Fermilab is managed by Fermi Research Alliance, LLC (FRA), acting under Contract No. DE-AC02-07CH11359. The DUNE collaboration also acknowledges the international, national, and regional funding agencies supporting the institutions who have contributed to completing this Technical Design Report., The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. DUNE is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. Central to achieving DUNE's physics program is a far detector that combines the many tens-of-kiloton fiducial mass necessary for rare event searches with sub-centimeter spatial resolution in its ability to image those events, allowing identification of the physics signatures among the numerous backgrounds. In the single-phase liquid argon time-projection chamber (LArTPC) technology, ionization charges drift horizontally in the liquid argon under the influence of an electric field towards a vertical anode, where they are read out with fine granularity. A photon detection system supplements the TPC, directly enhancing physics capabilities for all three DUNE physics drivers and opening up prospects for further physics explorations. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume IV presents an overview of the basic operating principles of a single-phase LArTPC, followed by a description of the DUNE implementation. Each of the subsystems is described in detail, connecting the high-level design requirements and decisions to the overriding physics goals of DUNE., Fermi Research Alliance, LLC (FRA) DE-AC02-07CH11359

Published
2020

26. Volume I. Introduction to DUNE

Author

E. Hazen, Armin Karcher, D. Smargianaki, Christopher L. Marshall, K. Spurgeon, M. Gold, C. Vignoli, C. J. Solano Salinas, M. J. Wilking, K. Kothekar, G. Sirri, Evgueni Goudzovski, H. Mendez, W. Flanagan, V. Papadimitriou, D. Redondo, S. R. Mishra, Y.-J. Jwa, G. Petrillo, M. Spanu, Xiaolu Ji, O. V. Mineev, M. Bishai, S. Menary, L. Molina Bueno, P. C. de Holanda, H. Berns, A. Gendotti, A. M. Szelc, R. Gandhi, A. Himmel, M. Rajaoalisoa, P. Bour, N. Kazaryan, L. Mualem, Gareth J. Barker, C. Cattadori, S. Ravat, W. Mu, D. Marfatia, T. Miedema, Kendall Mahn, Jorge Molina, Filippo Resnati, S. Magill, E. Niner, D. Autiero, Poonam Mehta, John Evans, J. S. Díaz, P. Novella, J. Fowler, G. Karagiorgi, S. J. M. Peeters, William J. Marciano, S. Bordoni, James Mueller, J. Martín-Albo, W. Fox, K. Grzelak, C. Hohl, R. Haenni, S. Alonso Monsalve, B. Howard, G. Ge, Alexander Tapper, Thomas Strauss, Silvia Pascoli, B. Stillwell, A. Lambert, A. Holin, K. V. Tsang, J. Maneira, R.A. Rameika, Juraj Bracinik, C. Wret, M. Tenti, Alberto Cervelli, Sukalyan Chattopadhyay, Laura Dominé, K. Herner, Hem Raj Sharma, S. Kasai, A. Higuera Pichardo, M. Betancourt, A. Scarff, R. Northrop, M. V. Diwan, D. J. Payne, C. Gotti, M. A. Vermeulen, R. M. Berner, J. J. De Vries, S. Shafaq, Yu. G. Kudenko, L. Pickering, B. Bhuyan, C. Kuruppu, Janet Conrad, D. Brailsford, R. Van Berg, J. Chaves, B. Paulos, R. Sipos, E. Pennacchio, F. W. Sippach, T. Li, S. Striganov, Laura Paulucci, S. Manly, P. Hamilton, R. G. Van de Water, R. Nandakumar, B. Szczerbinska, D. Cherdack, H. Carranza, Milos Lokajicek, K. Nishimura, E. Kearns, A. C. Ezeribe, J. Hoff, A. McNab, A. Stuart, G. Vasseur, C. Petta, M. Wetstein, M. M. Khabibullin, A. Bitadze, Yichen Li, G. Brunetti, L. Suter, L. Pasqualini, S. Martynenko, Ph. Lebrun, B. Morgan, L. Patrizii, A. Guglielmi, D. Wenman, S. C. Timm, R. Sharma, R. Saakyan, R. Gran, C. McGrew, C. Andreopoulos, A. Mann, F. Terranova, C. Cuesta, O. G. Miranda, C. 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B., Patton, S., Patzak, T., Paudel, A., Paulos, B., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Peeters, S. J., Penichot, Y., Pennacchio, E., Penzo, A., Peres, O. L., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Piastra, F., Pickering, L., Pietropaolo, F., Pillow, J., Plunkett, R., Poling, R., Pons, X., Poonthottathil, N., Pordes, S., Potekhin, M., Potenza, R., Potukuchi, B. V., Pozimski, J., Pozzato, M., Prakash, S., Prakash, T., Prince, S., Prior, G., Pugnere, D., Qi, K., Qian, X., Raaf, J., Raboanary, R., Radeka, V., Rademacker, J., Radics, B., Rafique, A., Raguzin, E., Rai, M., Rajaoalisoa, M., Rakhno, I., Rakotondramanana, H., Rakotondravohitra, L., Ramachers, Y., Rameika, R., Delgado, M. Ramirez, Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Ravat, S., Razafinime, H., Real, J., Rebel, B., Redondo, D., Reggiani-Guzzo, M., Rehak, T., Reichenbacher, J., Reitzner, S. 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A., Terranova, F., Testera, G., Thea, A., Thompson, J. L., Thorn, C., Timm, S., Tonazzo, A., Torti, M., Tortola, M., Tortorici, F., Totani, D., Toups, M., Touramanis, C., Trevor, J., Trzaska, W. H., Tsai, Y. T., Tsamalaidze, Z., Tsang, K., Tsverava, N., Tufanli, S., Tull, C., Tyley, E., Tzanov, M., Uchida, M. A., Urheim, J., Usher, T., Vagins, M., Vahle, P., Valdiviesso, G., Valencia, E., Vallari, Z., Valle, J. W., Vallecorsa, S., Berg, R. Van, de Water, R. G. Van, Forero, D. Vanega, Varanini, F., Vargas, D., Varner, G., Vasel, J., Vasseur, G., Vaziri, K., Ventura, S., Verdugo, A., Vergani, S., Vermeulen, M. A., Verzocchi, M., de Souza, H. Vieira, Vignoli, C., Vilela, C., Viren, B., Vrba, T., Wachala, T., Waldron, A. V., Wallbank, M., Wang, H., Wang, J., Wang, Y., Warburton, K., Warner, D., Wascko, M., Waters, D., Watson, A., Weatherly, P., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenman, D., Wetstein, M., While, M. R., White, A., Whitehead, L. H., Whittington, D., Wilking, M. J., Wilkinson, C., Williams, Z., Wilson, F., Wilson, R. J., Wolcott, J., Wongjirad, T., Wood, K., Wood, L., Worcester, E., Worcester, M., Wret, C., Wu, W., Xiao, Y., Yang, G., Yang, T., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, J., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G., Zennamo, J., Zeug, K., Zhang, C., Zhao, M., Zhivun, E., Zhu, G., Zimmerman, E. D., Zito, M., Zucchelli, S., Zuklin, J., Zutshi, V., and Zwaska, R.

Subjects
detector: technology, deep underground detector [neutrino], 530 Physics, Physics::Instrumentation and Detectors, Data management, media_common.quotation_subject, far detector, Long baseline neutrino experiment CP violation, 01 natural sciences, 030218 nuclear medicine & medical imaging, Neutrino oscillations. Neutrino Detectors. CP violation. Matter stability, design [detector], 03 medical and health sciences, neutrino, neutrino: deep underground detector, 0302 clinical medicine, near detector, 0103 physical sciences, Deep Underground Neutrino Experiment, ddc:610, Neutrino oscillation, Instrumentation, detector: design, Mathematical Physics, activity report, media_common, 010308 nuclear & particles physics, business.industry, Detector, Volume (computing), Modular design, time projection chamber: liquid argon, Universe, technology [detector], liquid argon [time projection chamber], Systems engineering, High Energy Physics::Experiment, Neutrino oscillations, DUNE technical design report, executive summary, detector technologies, data management, Neutrino, business
Abstract

Journal of Instrumentation 15(08), T08008 (1-228) (2020). doi:10.1088/1748-0221/15/08/T08008, The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. This TDR is intended to justify the technical choices for the far detector that flow down from the high-level physics goals through requirements at all levels of the Project. Volume I contains an executive summary that introduces the DUNE science program, the far detector and the strategy for its modular designs, and the organization and management of the Project. The remainder of Volume I provides more detail on the science program that drives the choice of detector technologies and on the technologies themselves. It also introduces the designs for the DUNE near detector and the DUNE computing model, for which DUNE is planning design reports. Volume II of this TDR describes DUNE's physics program in detail. Volume III describes the technical coordination required for the far detector design, construction, installation, and integration, and its organizational structure. Volume IV describes the single-phase far detector technology. A planned Volume V will describe the dual-phase technology., Published by Inst. of Physics, London

Published
2020

27. First results on ProtoDUNE-SP liquid argon time projection chamber performance from a beam test at the CERN Neutrino Platform

Author

Francesco Tortorici, Andrea Zani, J. Moon, P. E. L. Clarke, C. Palomares, M. B. Smy, M. Oberling, J. Migenda, F. Pietropaolo, T. Hasegawa, A. de Gouvea, N.V. Mokhov, S. Rescia, Andrés Castillo, F. Marinho, Mario Campanelli, Jürgen Pozimski, R. Raboanary, F. Sergiampietri, D. A. Sanders, John F. Beacom, Steven Gardiner, P. Madigan, R. Sulej, M. V. Diwan, D. J. Payne, L. Pickering, S. Manly, P. Hamilton, R. G. Van de Water, Chao Zhang, J. Wang, J. Hoff, Burak Bilki, Rex Tayloe, M. A. Uchida, A. Stuart, O. Dvornikov, P. De Lurgio, C. A. Ternes, J. A. Nowak, R. Bajou, P. Schlabach, E. Seltskaya, C. Lastoria, D. Naples, Kazuhiro Terao, A. Paudel, E. T. Worcester, C. Gotti, Michael Mulhearn, S. B. Boyd, T. Hill, D. Douglas, Daniel Gastler, G. A. Valdiviesso, S. Emery, M. C. Goodman, D. C. Christian, M. Newcomer, H. W. Sobel, N. Poonthottathil, Mingshui Chen, J. Urheim, B. Viren, D. Montanari, Giorgio Riccobene, I. Rakhno, M. A. Ramirez Delgado, J. Mousseau, Ara Ioannisian, H. T. Rakotondramanana, L. Molina Bueno, A. Rappoldi, Matthaeus Leitner, K. Fahey, S. J. Brice, M. E. Convery, Nicolas Lurkin, Bindu A. Bambah, S. Ravat, W. Mu, M. A. Arroyave, A. A. Machado, R. Petti, Rukmani Mohanta, Andrew Norman, V. N. Solovov, X. Pons, J. Marteau, Irakli Lomidze, Zviad Tsamalaidze, H. da Motta, M. Mellinato, M. Karolak, D. Autiero, Poonam Mehta, G. Karagiorgi, Sudarshan Paramesvaran, S. Davini, R. L. Talaga, V. Paolone, V. Pec, J. Pillow, S. Vergani, Simon Lin, K. Wood, Jaroslaw Pasternak, G. C. Blazey, Katsuya Yonehara, T. E. Coan, B. Radics, W. Gu, A. M. Teklu, E. Blucher, S. Childress, S. Matsuno, Christian Farnese, Akitaka Ariga, Marvin L Marshak, A. Chiriacescu, F. Terranova, E. Raguzin, L. C. J. Rice, L. Domine, M. Pozzato, T. Miao, L. Da Silva Peres, D. Mladenov, T. Durkin, H. Y. Wei, L. Escudero Sanchez, T. Usher, A. Rafique, A. Verdugo, B. Stillwell, A. Lambert, K. Negishi, A. Falcone, A. Holin, J. L. Bazo Alba, J. Rout, E. D. Zimmerman, M. A. Leigui de Oliveira, A. Olivier, J. Nesbit, Aldo Penzo, Kate Scholberg, Giovanni Bellettini, S. Kasai, O. Gogota, B. Ramson, P. de Jong, R. Zaki, A. Tonazzo, H. Schellman, E. Kemp, T. Rehak, I. De Bonis, Pedro A. N. Machado, B. T. Fleming, M. P. Andrews, M. Bishai, T. Alion, N. Martinez, L. Greenler, Deywis Moreno, T. Loew, H. Berns, P. Ding, M. J. Dolinski, R. J. Nichol, B. Guo, Frank Filthaut, Stefan Antusch, Nikolaos Charitonidis, Patrick Green, R. Howell, Z. Parsa, M. Sorel, J. C. Freeman, J. A. Musser, D. Gratieri, J. Reichenbacher, S. Ventura, Kaushik De, M. J. Rodriguez Alonso, Patrick Dunne, A. Scaramelli, M. Tenti, J. R. T. de Mello Neto, Raj Gandhi, Riccardo Papaleo, M. C. Sanchez, V. Zutshi, Sandeep Miryala, Enrique Calvo, N. Tsverava, V. Radeka, C. Touramanis, J. M. Paley, Antonio Ereditato, J. S. Díaz, Marco Pallavicini, D. MacFarland, G. Savage, J. Soto-Oton, P. Fernandez Menendez, J. Han, C. Y. Chi, M. Groh, N. Yershov, M. Chalifour, E. Hazen, M. A. Acero, C. Mossey, L. M. Montano Zetina, W. C. Louis, S. Di Domizio, F. Bento Neves, A. Gendotti, A. Himmel, M. Masud, M. Rajaoalisoa, P. Bour, G. Pessina, P. Novella, Armin Karcher, D. Smargianaki, Christopher L. Marshall, M. Gold, C. Vignoli, L. Mualem, A. Sousa, K. Kothekar, A. Surdo, J. Martín-Albo, Z. Ghorbani-Moghaddam, K. Spurgeon, E. Niner, M. Spanu, Xiaolu Ji, E. Fernandez-Martinez, W. Flanagan, Jonas Rademacker, G. P. Zeller, Joshua Barrow, John Marshall, A. M. Szelc, J. J. Russell, M. J. Wilking, V. Papadimitriou, Gareth J. Barker, A. M. Gago, R. Diurba, G. Christodoulou, S. Calvez, Jeremy Wolcott, R. S. Fitzpatrick, D. Redondo, S. R. Mishra, Gregory Iles, Andrew Brandt, S. Bordoni, James Mueller, G. Zhu, S. Centro, S. Henry, L. Rakotondravohitra, K. Grzelak, Paul Keener, Leigh H. Whitehead, Matthew Mewes, Kai Loo, Karol Hennessy, S. Söldner-Rembold, C. S. Lin, J. Trevor, N. Kazaryan, Kendall Mahn, Jorge Molina, J. Fowler, Dave Sankey, Luca Stanco, W. Fox, K. M. Heeger, R. Poling, S. J. M. 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S. Hesam, S. H. Kettell, Alessandro Thea, Y.-J. Jwa, M. Bongrand, Nikolina Ilic, David Delepine, A. L. Renshaw, I. Caro Terrazas, R. Gran, Hui Wang, V. Bellini, C. Alt, B. Abi, A. Caminata, N. Moggi, R. Illingworth, E. Pennacchio, Claire Shepherd-Themistocleous, M. Roda, M. Tzanov, F. Bay, H.E. Rogers, Andrea Dell'Acqua, F. W. Sippach, T. Li, A. P. Furmanski, P.T. Smith, L. O. Arnold, A. Guglielmi, T. Hamernik, C. E. Lane, Yu.A. Kudenko, Y. Bezawada, V. P. Luzio, W. C. Griffith, D. Newhart, E. Kearns, A. J. Roeth, R. Acciarri, A. C. Ezeribe, H. R. Gallagher, L. Suter, D. Brailsford, Chia-Chan Chang, J. Zuklin, Karol Lang, D. A. Harris, C. Distefano, Ornella Palamara, Laura Paulucci, H. S. Budd, Rakesh Kumar, F. Stocker, T. Gamble, F. Muheim, J. J. Grudzinski, Ralf Lehnert, G. Petrillo, T. Miedema, S. Magill, K. Cho, S. Martynenko, Ph. Lebrun, A. Heavey, Grzegorz Deptuch, T. A. Bolton, J. Greer, L. Camilleri, S. Nagu, J. A. Maloney, Z. Vallari, D. Duchesneau, X. Luo, Y. Xiao, K. Lande, C. Rubbia, Sofia Andringa, F. Jediny, B. Morgan, L. Patrizii, P. Adrien, I. Gil-Botella, Artur M. Ankowski, J. Sensenig, B. V. K. S. Potukuchi, C. Brizzolari, Alastair Grant, A. G. Cocco, C. Morris, John Evans, F. F. Wilson, Nektarios Benekos, Renato Potenza, A. K. Giri, O. G. Miranda, M. Torti, M. Tortola, B. Jargowsky, B. Bhuyan, B. Carlus, D. Boyden, Cari L. Johnson, J. Freestone, D. Rivera, Matthew L Strait, G. Barenboim, C. Montanari, E. Conley, D. Totani, Sandhya Choubey, M. Rai, A. Mefodiev, Wayne A. Barkhouse, A. Cervelli, A. Papanestis, A. Aurisano, A. Norrick, A. Filkins, M. Toups, Kam-Biu Luk, K. Qi, J. A. B. Coelho, B. Howard, S. Fuess, E. Cristaldo, H. Razafinime, D. Edmunds, J. J. Back, G. Salukvadze, Alessandro Montanari, S. Balasubramanian, D. Pugnere, G.D. Barr, Junwei Huang, V. De Romeri, P. Guzowski, R. Itay, T. Safford, E. Tatar, Marc Weber, Utku Kose, S. Santana, F. Barao, A. Cervera Villanueva, Robert Svoboda, C. Mariani, Carlos Escobar, C. A. Moura, A. D. Marino, Giuseppe Benedetto Cerati, J. Vasel, Piera Sapienza, M. Shamma, Z. Djurcic, Haleh Khani Hadavand, D. Caratelli, L. Bellantoni, V. Savinov, P. Melas, J. A. Gonzalez-Cuevas, Juraj Bracinik, N. P. Samios, A. Hackenburg, Kevin J. Kelly, D. Sgalaberna, B. Tapia Oregui, D. Caiulo, Sergey A. Kulagin, A. Bashyal, N. Nayak, E. Granados, B. Behera, R. B. Patterson, D. Vargas, Sukalyan Chattopadhyay, Beatriz B. Siffert, B. Lacarelle, B. Kirby, A. Bross, D. Warner, C. E. Thorn, G. Prior, P. Lasorak, V. Susic, S. D. Reitzner, H. Duyang, H. Meyer, Olga Mena, A. Scarff, A. Schukraft, R. Mazza, Kim Siyeon, A. Mazzacane, R. Northrop, H. Z. Yu, Timothy M. Shaw, D. Braga, F. Bonini, Marcelo M. Guzzo, R. Van Berg, J. Chaves, P. Bernardini, J. Ahmed, Narendra Sahu, P. Baesso, T. R. Junk, B. Paulos, C. Sarasty, S. Gao, R. Sipos, J. Stock, M. Biassoni, J. Maneira, R.A. Rameika, S. Gwon, M. O. Wascko, Konstantinos Manolopoulos, R. K. Plunkett, L. Corwin, S. L. Mufson, Sandip Pakvasa, A. Joglekar, D. Pershey, R. Nandakumar, K. S. McFarland, C. T. Macias, J. Maricic, O. Goodwin, T. Yang, K. K. Guthikonda, G. Meng, M. A. Vermeulen, V. Basque, D. Franco, Julián Félix, M. Wetstein, M. Soares Nunes, K. Gollwitzer, E. Ewart, Claire David, D. Marfatia, R. M. Berner, A. Maddalena, M. Antonova, H. O. Back, T. Boschi, M. M. Khabibullin, J. J. De Vries, S. Shafaq, S. Gollapinni, A. McNab, G. Vasseur, S. Sacerdoti, J. Calcutt, K. Warburton, M. Nalbandyan, D. Wenman, S. C. Timm, R. Sharma, F. Varanini, J. Heise, C. Petta, R. LaZur, Maurizio Bonesini, R. Saakyan, Kristian Harder, J. Hewes, F. Diaz, Sandro Palestini, R. Hatcher, M. Zhao, M. Vagins, C. Grant, L. Kashur, F. Cavalier, K. Haaf, Christopher Brew, Pavel Snopok, C. Bromberg, A. Olivares Del Campo, Joshua R. Klein, M. Parvu, James A. Anderson, Jack Fried, Y. Rigaut, J. Hugon, G. S. Davies, Vasundhara Singh, L. Di Noto, W. E. Sondheim, C. E. Tull, M. Kirby, M. Adamowski, Kenneth Long, K. Soustruznik, J. Mills, H. W. 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B., Boyden, D., Bracinik, J., Braga, D., Brailsford, D., Brandt, A., Bremer, J., Brew, C., Brianne, E., Brice, S. J., Brizzolari, C., Bromberg, C., Brooijmans, G., Brooke, J., Bross, A., Brunetti, G., Buchanan, N., Budd, H., Caiulo, D., Calafiura, P., Calcutt, J., Calin, M., Calvez, S., Calvo, E., Camilleri, L., Caminata, A., Campanelli, M., Caratelli, D., Carini, G., Carlus, B., Carniti, P., Terrazas, I. C., Carranza, H., Castillo, A., Castromonte, C., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cervelli, A., Villanueva, A. C., Chalifour, M., Chang, C., Chardonnet, E., Charitonidis, N., Chatterjee, A., Chattopadhyay, S., Chatzidaki, P., Chaves, J., Chen, H., Chen, M., Chen, Y., Cherdack, D., Chi, C., Childress, S., Chiriacescu, A., Cho, K., Choubey, S., Christensen, A., Christian, D., Christodoulou, G., Church, E., Clarke, P., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Conley, E., Conrad, J. 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S., Eads, M., Edmunds, D., Eisch, J., Emery, S., Ereditato, A., Escobar, C. O., Sanchez, L. E., Evans, J. J., Ewart, E., Ezeribe, A. C., Fabre, C., Fahey, K., Falcone, A., Farnese, C., Farzan, Y., Felix, J., Fernandez-Martinez, E., Menendez, P. F., Ferraro, F., Fields, L., Filkins, A., Filthaut, F., Fitzpatrick, R. S., Flanagan, W., Fleming, B., Flight, R., Fowler, J., Fox, W., Franc, J., Francis, K., Franco, D., Freeman, J., Freestone, J., Fried, J., Friedland, A., Fuess, S., Furic, I., Furmanski, A. P., Gago, A., Gallagher, H., Gallego-Ros, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Gandhi, R., Gandrajula, R., Gao, S., Garcia-Gamez, D., Garcia-Peris, M., Gardiner, S., Gastler, D., Ge, G., Gelli, B., Gendotti, A., Gent, S., Ghorbani-Moghaddam, Z., Gibin, D., Gil-Botella, I., Girerd, C., Giri, A. K., Gnani, D., Gogota, O., Gold, M., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. V. G., Fajardo, L. S. G., Gonnella, F., Gonzalez-Cuevas, J. A., Goodman, M. C., Goodwin, O., Goswami, S., Gotti, C., Goudzovski, E., Grace, C., Graham, M., Gramellini, E., Gran, R., Granados, E., Grant, A., Grant, C., Gratieri, D., Green, P., Green, S., Greenler, L., Greenwood, M., Greer, J., Griffith, W. C., Groh, M., Grudzinski, J., Grzelak, K., Gu, W., Guarino, V., Guenette, R., Guglielmi, A., Guo, B., Guthikonda, K. K., Gutierrez, R., Guzowski, P., Guzzo, M. M., Gwon, S., Haaf, K., Habig, A., Hackenburg, A., Hadavand, H., Haenni, R., Hahn, A., Haigh, J., Haiston, J., Hamernik, T., Hamilton, P., Han, J., Harder, K., Harris, D. A., Hartnell, J., Hasegawa, T., Hatcher, R., Hazen, E., Heavey, A., Heeger, K. M., Heise, J., Hennessy, K., Henry, S., Morquecho, M. A. H., Herner, K., Hertel, L., Hesam, A. S., Hewes, J., Higuera, A., Hill, T., Hillier, S. J., Himmel, A., Hoff, J., Hohl, C., Holin, A., Hoppe, E., Horton-Smith, G. A., Hostert, M., Hourlier, A., Howard, B., Howell, R., Hrivnak, J., Huang, J., Hugon, J., Iles, G., Ilic, N., Iliescu, A. M., Illingworth, R., Ioannisian, A., Itay, R., Izmaylov, A., James, E., Jargowsky, B., Jediny, F., Jes s-Valls, C., Ji, X., Jiang, L., Jimenez, S., Jipa, A., Joglekar, A., Johnson, C., Johnson, R., Jones, B., Jones, S., Jung, C. K., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A., Kadenko, I., Kamiya, F., Karagiorgi, G., Karcher, A., Karolak, M., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Kazaryan, N., Kearns, E., Keener, P., Kelly, K. J., Kemp, E., Kendziora, C., Ketchum, W., Kettell, S. H., Khabibullin, M., Khotjantsev, A., Khvedelidze, A., Kim, D., King, B., Kirby, B., Kirby, M., Klein, J., Koehler, K., Koerner, L. W., Kohn, S., Koller, P. P., Kordosky, M., Kosc, T., Kose, U., Kostelecky, V. A., Kothekar, K., Krennrich, F., Kreslo, I., Kudenko, Y., Kudryavtsev, V. A., Kulagin, S., Kumar, J., Kumar, R., Kuruppu, C., Kus, V., Kutter, T., Lacarelle, B., Lambert, A., Lande, K., Lane, C. E., Lang, K., Langford, T., Lasorak, P., Last, D., Lastoria, C., Laundrie, A., Lawrence, A., Lazanu, I., Lazur, R., Le, T., Learned, J., Lebrun, P., Miotto, G. L., Lehnert, R., De Oliveira, M. A. L., Leitner, M., Leyton, M., Li, L., Li, S., Li, S. W., Li, T., Li, Y., Liao, H., Lin, C. S., Lin, S., Lister, A., Littlejohn, B. R., Liu, J., Liu, T., Lockwitz, S., Loew, T., Lokajicek, M., Lomidze, I., Long, K., Loo, K., Lorca, D., Lord, T., Losecco, J. M., Louis, W. C., Luk, K. B., Luo, X., Lurkin, N., Lux, T., Luzio, V. P., Macfarland, D., Machado, A. A., Machado, P., Macias, C. T., Macier, J. R., Maddalena, A., Madigan, P., Magill, S., Mahn, K., Maio, A., Maloney, J. A., Mandrioli, G., Maneira, J., Manenti, L., Manly, S., Mann, A., Manolopoulos, K., Plata, M. M., Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marinho, F., Marino, A. D., Marshak, M., Marshall, C., Marshall, J., Marteau, J., Martin-Albo, J., Martinez, N., Martinez Caicedo, D. A., Martynenko, S., Mason, K., Mastbaum, A., Masud, M., Matsuno, S., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mazza, R., Mazzacane, A., Mazzucato, E., Mccluskey, E., Mcconkey, N., Mcfarland, K. S., Mcgrew, C., Mcnab, A., Mefodiev, A., Mehta, P., Melas, P., Mellinato, M., Mena, O., Menary, S., Mendez, H., Menegolli, A., Meng, G., Messier, M. D., Metcalf, W., Mewes, M., Meyer, H., Miao, T., Michna, G., Miedema, T., Migenda, J., Milincic, R., Miller, W., Mills, J., Milne, C., Mineev, O., Miranda, O. G., Miryala, S., Mishra, C. S., Mishra, S. R., Mislivec, A., Mladenov, D., Mocioiu, I., Moffat, K., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J., Bueno, L. M., Montanari, A., Montanari, C., Montanari, D., Zetina, L. M. M., Moon, J., Mooney, M., Moor, A., Moreno, D., Morgan, B., Morris, C., Mossey, C., Motuk, E., Moura, C. A., Mousseau, J., Mu, W., Mualem, L., Mueller, J., Muether, M., Mufson, S., Muheim, F., Muir, A., Mulhearn, M., Muramatsu, H., Murphy, S., Musser, J., Nachtman, J., Nagu, S., Nalbandyan, M., Nandakumar, R., Naples, D., Narita, S., Navas-Nicolas, D., Nayak, N., Nebot-Guinot, M., Necib, L., Negishi, K., Nelson, J. K., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Newhart, D., Nichol, R., Niner, E., Nishimura, K., Norman, A., Norrick, A., Northrop, R., Novella, P., Nowak, J. A., Oberling, M., Campo, A. O. D., Olivier, A., Onel, Y., Onishchuk, Y., Ott, J., Pagani, L., Pakvasa, S., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Pantic, E., Paolone, V., Papadimitriou, V., Papaleo, R., Papanestis, A., Paramesvaran, S., Parke, S., Parsa, Z., Parvu, M., Pascoli, S., Pasqualini, L., Pasternak, J., Pater, J., Patrick, C., Patrizii, L., Patterson, R. B., Patton, S. J., Patzak, T., Paudel, A., Paulos, B., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Peeters, S. J. M., Penichot, Y., Pennacchio, E., Penzo, A., Peres, O. L. G., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Piastra, F., Pickering, L., Pietropaolo, F., Pillow, J., Pinzino, J., Plunkett, R., Poling, R., Pons, X., Poonthottathil, N., Pordes, S., Potekhin, M., Potenza, R., Potukuchi, B. V. K. S., Pozimski, J., Pozzato, M., Prakash, S., Prakash, T., Prince, S., Prior, G., Pugnere, D., Qi, K., Qian, X., Raaf, J. L., Raboanary, R., Radeka, V., Rademacker, J., Radics, B., Rafique, A., Raguzin, E., Rai, M., Rajaoalisoa, M., Rakhno, I., Rakotondramanana, H. T., Rakotondravohitra, L., Ramachers, Y. A., Rameika, R., Delgado, M. A. R., Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Ravat, S., Razafinime, H., Real, J. S., Rebel, B., Redondo, D., Reggiani-Guzzo, M., Rehak, T., Reichenbacher, J., Reitzner, S. D., Renshaw, A., Rescia, S., Resnati, F., Reynolds, A., Riccobene, G., Rice, L. C. J., Rielage, K., Rigamonti, A., Rigaut, Y., Rivera, D., Rochester, L., Roda, M., Rodrigues, P., Alonso, M. J. R., Rondon, J. R., Roeth, A. J., Rogers, H., Rosauro-Alcaraz, S., Rosenthal, M., Rossella, M., Rout, J., Roy, S., Rubbia, A., Rubbia, C., Russell, B., Russell, J., Ruterbories, D., Saakyan, R., Sacerdoti, S., Safford, T., Sahu, N., Sala, P., Salukvadze, G., Samios, N., Sanchez, M. C., Sanders, D. A., Sankey, D., Santana, S., Santos-Maldonado, M., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Savage, G., Savinov, V., Scaramelli, A., Scarff, A., Scarpelli, A., Schellman, H., Schlabach, P., Schmitz, D., Scholberg, K., Schukraft, A., Segreto, E., Seltskaya, E., Sensenig, J., Seong, I., Sergi, A., Sergiampietri, F., Sgalaberna, D., Shaevitz, M. H., Shafaq, S., Shamma, M., Sharma, H. 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A., Terranova, F., Testera, G., Thea, A., Thompson, J. L., Thorn, C., Timm, S. C., Tonazzo, A., Torti, M., Tortola, M., Tortorici, F., Totani, D., Toups, M., Touramanis, C., Trevor, J., Trzaska, W. H., Tsai, Y. T., Tsamalaidze, Z., Tsang, K. V., Tsverava, N., Tufanli, S., Tull, C., Tyley, E., Tzanov, M., Uchida, M. A., Urheim, J., Usher, T., Vagins, M. R., Vahle, P., Valdiviesso, G. A., Valencia, E., Vallari, Z., Valle, J. W. F., Vallecorsa, S., Berg, R. V., De Water, R. G. V., Forero, D. V., Varanini, F., Vargas, D., Varner, G., Vasel, J., Vasseur, G., Vaziri, K., Ventura, S., Verdugo, A., Vergani, S., Vermeulen, M. A., Verzocchi, M., De Souza, H. V., Vignoli, C., Vilela, C., Viren, B., Vrba, T., Wachala, T., Waldron, A. V., Wallbank, M., Wang, H., Wang, J., Wang, Y., Warburton, K., Warner, D., Wascko, M., Waters, D., Watson, A., Weatherly, P., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenman, D., Wetstein, M., While, M. R., White, A., Whitehead, L. H., Whittington, D., Wilking, M. J., Wilkinson, C., Williams, Z., Wilson, F., Wilson, R. J., Wolcott, J., Wongjirad, T., Wood, K., Wood, L., Worcester, E., Worcester, M., Wret, C., Wu, W., Xiao, Y., Yang, G., Yang, T., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, H. W., Yu, H. Z., Yu, J., Yu, Z. Y., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G. P., Zennamo, J., Zeug, K., Zhang, C., Zhao, M., Zhivun, E., Zhu, G., Zimmerman, E. D., Zito, M., Zucchelli, S., Zuklin, J., Zutshi, V., Zwaska, R., Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), DUNE, Abi, B, Abud, A, Acciarri, R, Acero, M, Adamov, G, Adamowski, M, Adams, D, Adrien, P, Adinolfi, M, Ahmad, Z, Ahmed, J, Alion, T, Monsalve, S, Alt, C, Anderson, J, Andreopoulos, C, Andrews, M, Andrianala, F, Andringa, S, Ankowski, A, Antonova, M, Antusch, S, Aranda-Fernandez, A, Ariga, A, Arnold, L, Arroyave, M, Asaadi, J, Aurisano, A, Aushev, V, Autiero, D, Azfar, F, Back, H, Back, J, Backhouse, C, Baesso, P, Bagby, L, Bajou, R, Balasubramanian, S, Baldi, P, Bambah, B, Barao, F, Barenboim, G, Barker, G, Barkhouse, W, Barnes, C, Barr, G, Monarca, J, Barros, N, Barrow, J, Bashyal, A, Basque, V, Bay, F, Alba, J, Beacom, J, Bechetoille, E, Behera, B, Bellantoni, L, Bellettini, G, Bellini, V, Beltramello, O, Belver, D, Benekos, N, Neves, F, Berger, J, Berkman, S, Bernardini, P, Berner, R, Berns, H, Bertolucci, S, Betancourt, M, Bezawada, Y, Bhattacharjee, M, Bhuyan, B, Biagi, S, Bian, J, Biassoni, M, Biery, K, Bilki, B, Bishai, M, Bitadze, A, Blake, A, Siffert, B, Blaszczyk, F, Blazey, G, Blucher, E, Boissevain, J, Bolognesi, S, Bolton, T, Bonesini, M, Bongrand, M, Bonini, F, Booth, A, Booth, C, Bordoni, S, Borkum, A, Boschi, T, Bostan, N, Bour, P, Boyd, S, Boyden, D, Bracinik, J, Braga, D, Brailsford, D, Brandt, A, Bremer, J, Brew, C, Brianne, E, Brice, S, Brizzolari, C, Bromberg, C, Brooijmans, G, Brooke, J, Bross, A, Brunetti, G, Buchanan, N, Budd, H, Caiulo, D, Calafiura, P, Calcutt, J, Calin, M, Calvez, S, Calvo, E, Camilleri, L, Caminata, A, Campanelli, M, Caratelli, D, Carini, G, Carlus, B, Carniti, P, Terrazas, I, Carranza, H, Castillo, A, Castromonte, C, Cattadori, C, Cavalier, F, Cavanna, F, Centro, S, Cerati, G, Cervelli, A, Villanueva, A, Chalifour, M, Chang, C, Chardonnet, E, Charitonidis, N, Chatterjee, A, Chattopadhyay, S, Chatzidaki, P, Chaves, J, Chen, H, Chen, M, Chen, Y, Cherdack, D, Chi, C, Childress, S, Chiriacescu, A, Cho, K, Choubey, S, Christensen, A, Christian, D, Christodoulou, G, Church, E, Clarke, P, Coan, T, Cocco, A, Coelho, J, Conley, E, Conrad, J, Convery, M, Corwin, L, Cotte, P, Cremaldi, L, Cremonesi, L, Crespo-Anadon, J, Cristaldo, E, Cross, R, Cuesta, C, Cui, Y, Cussans, D, Dabrowski, M, Motta, H, Peres, L, David, C, David, Q, Davies, G, Davini, S, Dawson, J, De, K, Almeida, R, Debbins, P, Bonis, I, Decowski, M, De Gouv a, A, Holanda, P, Astiz, I, Deisting, A, Jong, P, Delbart, A, Delepine, D, Delgado, M, Dell'Acqua, A, Lurgio, P, Neto, J, Demuth, D, Dennis, S, Densham, C, Deptuch, G, Roeck, A, Romeri, V, Vries, J, Dharmapalan, R, Dias, M, Diaz, F, Diaz, J, Domizio, S, Giulio, L, Ding, P, Noto, L, Distefano, C, Diurba, R, Diwan, M, Djurcic, Z, Dokania, N, Dolinski, M, Domine, L, Douglas, D, Drielsma, F, Duchesneau, D, Duffy, K, Dunne, P, Durkin, T, Duyang, H, Dvornikov, O, Dwyer, D, Dyshkant, A, Eads, M, Edmunds, D, Eisch, J, Emery, S, Ereditato, A, Escobar, C, Sanchez, L, Evans, J, Ewart, E, Ezeribe, A, Fabre, C, Fahey, K, Falcone, A, Farnese, C, Farzan, Y, Felix, J, Fernandez-Martinez, E, Menendez, P, Ferraro, F, Fields, L, Filkins, A, Filthaut, F, Fitzpatrick, R, Flanagan, W, Fleming, B, Flight, R, Fowler, J, Fox, W, Franc, J, Francis, K, Franco, D, Freeman, J, Freestone, J, Fried, J, Friedland, A, Fuess, S, Furic, I, Furmanski, A, Gago, A, Gallagher, H, Gallego-Ros, A, Gallice, N, Galymov, V, Gamberini, E, Gamble, T, Gandhi, R, Gandrajula, R, Gao, S, Garcia-Gamez, D, Garcia-Peris, M, Gardiner, S, Gastler, D, Ge, G, Gelli, B, Gendotti, A, Gent, S, Ghorbani-Moghaddam, Z, Gibin, D, Gil-Botella, I, Girerd, C, Giri, A, Gnani, D, Gogota, O, Gold, M, Gollapinni, S, Gollwitzer, K, Gomes, R, Bermeo, L, Fajardo, L, Gonnella, F, Gonzalez-Cuevas, J, Goodman, M, Goodwin, O, Goswami, S, Gotti, C, Goudzovski, E, Grace, C, Graham, M, Gramellini, E, Gran, R, Granados, E, Grant, A, Grant, C, Gratieri, D, Green, P, Green, S, Greenler, L, Greenwood, M, Greer, J, Griffith, W, Groh, M, Grudzinski, J, Grzelak, K, Gu, W, Guarino, V, Guenette, R, Guglielmi, A, Guo, B, Guthikonda, K, Gutierrez, R, Guzowski, P, Guzzo, M, Gwon, S, Haaf, K, Habig, A, Hackenburg, A, Hadavand, H, Haenni, R, Hahn, A, Haigh, J, Haiston, J, Hamernik, T, Hamilton, P, Han, J, Harder, K, Harris, D, Hartnell, J, Hasegawa, T, Hatcher, R, Hazen, E, Heavey, A, Heeger, K, Heise, J, Hennessy, K, Henry, S, Morquecho, M, Herner, K, Hertel, L, Hesam, A, Hewes, J, Higuera, A, Hill, T, Hillier, S, Himmel, A, Hoff, J, Hohl, C, Holin, A, Hoppe, E, Horton-Smith, G, Hostert, M, Hourlier, A, Howard, B, Howell, R, Hrivnak, J, Huang, J, Hugon, J, Iles, G, Ilic, N, Iliescu, A, Illingworth, R, Ioannisian, A, Itay, R, Izmaylov, A, James, E, Jargowsky, B, Jediny, F, Jes s-Valls, C, Ji, X, Jiang, L, Jimenez, S, Jipa, A, Joglekar, A, Johnson, C, Johnson, R, Jones, B, Jones, S, Jung, C, Junk, T, Jwa, Y, Kabirnezhad, M, Kaboth, A, Kadenko, I, Kamiya, F, Karagiorgi, G, Karcher, A, Karolak, M, Karyotakis, Y, Kasai, S, Kasetti, S, Kashur, L, Kazaryan, N, Kearns, E, Keener, P, Kelly, K, Kemp, E, Kendziora, C, Ketchum, W, Kettell, S, Khabibullin, M, Khotjantsev, A, Khvedelidze, A, Kim, D, King, B, Kirby, B, Kirby, M, Klein, J, Koehler, K, Koerner, L, Kohn, S, Koller, P, Kordosky, M, Kosc, T, Kose, U, Kostelecky, V, Kothekar, K, Krennrich, F, Kreslo, I, Kudenko, Y, Kudryavtsev, V, 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Nesbit, J, Nessi, M, Newbold, D, Newcomer, M, Newhart, D, Nichol, R, Niner, E, Nishimura, K, Norman, A, Norrick, A, Northrop, R, Novella, P, Nowak, J, Oberling, M, Campo, A, Olivier, A, Onel, Y, Onishchuk, Y, Ott, J, Pagani, L, Pakvasa, S, Palamara, O, Palestini, S, Paley, J, Pallavicini, M, Palomares, C, Pantic, E, Paolone, V, Papadimitriou, V, Papaleo, R, Papanestis, A, Paramesvaran, S, Parke, S, Parsa, Z, Parvu, M, Pascoli, S, Pasqualini, L, Pasternak, J, Pater, J, Patrick, C, Patrizii, L, Patterson, R, Patton, S, Patzak, T, Paudel, A, Paulos, B, Paulucci, L, Pavlovic, Z, Pawloski, G, Payne, D, Pec, V, Peeters, S, Penichot, Y, Pennacchio, E, Penzo, A, Peres, O, Perry, J, Pershey, D, Pessina, G, Petrillo, G, Petta, C, Petti, R, Piastra, F, Pickering, L, Pietropaolo, F, Pillow, J, Pinzino, J, Plunkett, R, Poling, R, Pons, X, Poonthottathil, N, Pordes, S, Potekhin, M, Potenza, R, Potukuchi, B, Pozimski, J, Pozzato, M, Prakash, S, Prakash, T, Prince, S, Prior, G, Pugnere, D, Qi, K, Qian, X, Raaf, J, Raboanary, R, Radeka, V, Rademacker, J, Radics, B, Rafique, A, Raguzin, E, Rai, M, Rajaoalisoa, M, Rakhno, I, Rakotondramanana, H, Rakotondravohitra, L, Ramachers, Y, Rameika, R, Ramson, B, Rappoldi, A, Raselli, G, Ratoff, P, Ravat, S, Razafinime, H, Real, J, Rebel, B, Redondo, D, Reggiani-Guzzo, M, Rehak, T, Reichenbacher, J, Reitzner, S, Renshaw, A, Rescia, S, Resnati, F, Reynolds, A, Riccobene, G, Rice, L, Rielage, K, Rigamonti, A, Rigaut, Y, Rivera, D, Rochester, L, Roda, M, Rodrigues, P, Alonso, M, Rondon, J, Roeth, A, Rogers, H, Rosauro-Alcaraz, S, Rosenthal, M, Rossella, M, Rout, J, Roy, S, Rubbia, A, Rubbia, C, Russell, B, Russell, J, Ruterbories, D, Saakyan, R, Sacerdoti, S, Safford, T, Sahu, N, Sala, P, Salukvadze, G, Samios, N, Sanchez, M, Sanders, D, Sankey, D, Santana, S, Santos-Maldonado, M, Saoulidou, N, Sapienza, P, Sarasty, C, Sarcevic, I, Savage, G, Savinov, V, Scaramelli, A, Scarff, A, Scarpelli, A, Schellman, H, Schlabach, P, Schmitz, D, Scholberg, 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Worcester, E, Worcester, M, Wret, C, Wu, W, Xiao, Y, Yang, G, Yang, T, Yershov, N, Yonehara, K, Young, T, Yu, B, Yu, H, Yu, J, Yu, Z, Zaki, R, Zalesak, J, Zambelli, L, Zamorano, B, Zani, A, Zazueta, L, Zeller, G, Zennamo, J, Zeug, K, Zhang, C, Zhao, M, Zhivun, E, Zhu, G, Zimmerman, E, Zito, M, Zucchelli, S, Zuklin, J, Zutshi, V, Zwaska, R, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), XENON (IHEF, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), Abi B., Abud A.A., Acciarri R., Acero M.A., Adamov G., Adamowski M., Adams D., Adrien P., Adinolfi M., Ahmad Z., Ahmed J., Alion T., Monsalve S.A., Alt C., Anderson J., Andreopoulos C., Andrews M.P., Andrianala F., Andringa S., Ankowski A., Antonova M., Antusch S., Aranda-Fernandez A., Ariga A., Arnold L.O., Arroyave M.A., Asaadi J., Aurisano A., Aushev V., Autiero D., Azfar F., Back H., Back J.J., Backhouse C., Baesso P., Bagby L., Bajou R., Balasubramanian S., Baldi P., Bambah B., Barao F., Barenboim G., Barker G.J., Barkhouse W., Barnes C., Barr G., Monarca J.B., Barros N., Barrow J.L., Bashyal A., Basque V., Bay F., Alba J.L.B., Beacom J.F., Bechetoille E., Behera B., Bellantoni L., Bellettini G., Bellini V., Beltramello O., Belver D., Benekos N., Neves F.B., Berger J., Berkman S., Bernardini P., Berner R.M., Berns H., Bertolucci S., Betancourt M., Bezawada Y., Bhattacharjee M., Bhuyan B., Biagi S., Bian J., Biassoni M., Biery K., Bilki B., Bishai M., Bitadze A., Blake A., Siffert B.B., Blaszczyk F.D.M., Blazey G.C., 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T., Paudel A., Paulos B., Paulucci L., Pavlovic Z., Pawloski G., Payne D., Pec V., Peeters S.J.M., Penichot Y., Pennacchio E., Penzo A., Peres O.L.G., Perry J., Pershey D., Pessina G., Petrillo G., Petta C., Petti R., Piastra F., Pickering L., Pietropaolo F., Pillow J., Pinzino J., Plunkett R., Poling R., Pons X., Poonthottathil N., Pordes S., Potekhin M., Potenza R., Potukuchi B.V.K.S., Pozimski J., Pozzato M., Prakash S., Prakash T., Prince S., Prior G., Pugnere D., Qi K., Qian X., Raaf J.L., Raboanary R., Radeka V., Rademacker J., Radics B., Rafique A., Raguzin E., Rai M., Rajaoalisoa M., Rakhno I., Rakotondramanana H.T., Rakotondravohitra L., Ramachers Y.A., Rameika R., Delgado M.A.R., Ramson B., Rappoldi A., Raselli G., Ratoff P., Ravat S., Razafinime H., Real J.S., Rebel B., Redondo D., Reggiani-Guzzo M., Rehak T., Reichenbacher J., Reitzner S.D., Renshaw A., Rescia S., Resnati F., Reynolds A., Riccobene G., Rice L.C.J., Rielage K., Rigamonti A., Rigaut Y., Rivera D., Rochester L., Roda M., Rodrigues P., Alonso M.J.R., Rondon J.R., Roeth A.J., Rogers H., Rosauro-Alcaraz S., Rosenthal M., Rossella M., Rout J., Roy S., Rubbia A., Rubbia C., Russell B., Russell J., Ruterbories D., Saakyan R., Sacerdoti S., Safford T., Sahu N., Sala P., Salukvadze G., Samios N., Sanchez M.C., Sanders D.A., Sankey D., Santana S., Santos-Maldonado M., Saoulidou N., Sapienza P., Sarasty C., Sarcevic I., Savage G., Savinov V., Scaramelli A., Scarff A., Scarpelli A., Schellman H., Schlabach P., Schmitz D., Scholberg K., Schukraft A., Segreto E., Seltskaya E., Sensenig J., Seong I., Sergi A., Sergiampietri F., Sgalaberna D., Shaevitz M.H., Shafaq S., Shamma M., Sharma H.R., Sharma R., Shaw T., Shepherd-Themistocleous C., Shin S., Shooltz D., Shrock R., Simard L., Simos N., Sinclair J., Sinev G., Singh J., Singh V., Sipos R., Sippach F.W., Sirri G., Sitraka A., Siyeon K., Smargianaki D., Smith A., Smith E., Smith P., Smolik J., Smy M., Snopok P., Nunes M.S., Sobel H., Soderberg M., Salinas C.J.S., Soldner-Rembold S., Solomey N., Solovov V., Sondheim W.E., Sorel M., Soto-Oton J., Sousa A., Soustruznik K., Spagliardi F., Spanu M., Spitz J., Spooner N.J.C., Spurgeon K., Staley R., Stancari M., Stanco L., Stefan D., Steiner H.M., Stewart J., Stillwell B., Stock J., Stocker F., Stokes T., Strait M., Strauss T., Striganov S., Stuart A., Sulej R., Summers D., Surdo A., Susic V., Suter L., Sutera C.M., Svoboda R., Szczerbinska B., Szelc A.M., Talaga R., Tanaka H.A., Oregui B.T., Tapper A., Tariq S., Tatar E., Tayloe R., Teklu A.M., Tenti M., Terao K., Ternes C.A., Terranova F., Testera G., Thea A., Thompson J.L., Thorn C., Timm S.C., Tonazzo A., Torti M., Tortola M., Tortorici F., Totani D., Toups M., Touramanis C., Trevor J., Trzaska W.H., Tsai Y.T., Tsamalaidze Z., Tsang K.V., Tsverava N., Tufanli S., Tull C., Tyley E., Tzanov M., Uchida M.A., Urheim J., Usher T., Vagins M.R., Vahle P., Valdiviesso G.A., Valencia E., Vallari Z., Valle J.W.F., Vallecorsa S., Berg R.V., De Water R.G.V., Forero D.V., Varanini F., Vargas D., Varner G., Vasel J., Vasseur G., Vaziri K., Ventura S., Verdugo A., Vergani S., Vermeulen M.A., Verzocchi M., De Souza H.V., Vignoli C., Vilela C., Viren B., Vrba T., Wachala T., Waldron A.V., Wallbank M., Wang H., Wang J., Wang Y., Warburton K., Warner D., Wascko M., Waters D., Watson A., Weatherly P., Weber A., Weber M., Wei H., Weinstein A., Wenman D., Wetstein M., While M.R., White A., Whitehead L.H., Whittington D., Wilking M.J., Wilkinson C., Williams Z., Wilson F., Wilson R.J., Wolcott J., Wongjirad T., Wood K., Wood L., Worcester E., Worcester M., Wret C., Wu W., Xiao Y., Yang G., Yang T., Yershov N., Yonehara K., Young T., Yu B., Yu H.W., Yu H.Z., Yu J., Yu Z.Y., Zaki R., Zalesak J., Zambelli L., Zamorano B., Zani A., Zazueta L., Zeller G.P., Zennamo J., Zeug K., Zhang C., Zhao M., Zhivun E., Zhu G., Zimmerman E.D., Zito M., Zucchelli S., Zuklin J., Zutshi V., Zwaska R., and Science and Technology Facilities Council (STFC)

Subjects
Technology, HIGH-ENERGY, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, far detector, beam transport, Noble liquid detectors (scintillation, ionization, double-phase), Cms Experıment, 01 natural sciences, 7. Clean energy, 09 Engineering, Particle identification, High Energy Physics - Experiment, 030218 nuclear medicine & medical imaging, High Energy Physics - Experiment (hep-ex), 0302 clinical medicine, Noble liquid detectors (scintillation, Detectors and Experimental Techniques, Instrumentation, Instruments & Instrumentation, physics.ins-det, time resolution, Mathematical Physics, Physics, 02 Physical Sciences, Time projection chamber, Large Hadron Collider, Detector, Instrumentation and Detectors (physics.ins-det), double-phase), Nuclear & Particles Physics, LIGHT, Neutrino, Particle Physics - Experiment, performance, Noble liquid detectors,(scintillation, ionization, double-phase), noise, CERN Lab, Large detector systems for particle and astroparticle physics, Noble liquid detectors (scintillation, ionization, double-phase), Time projection Chambers (TPC), 530 Physics, energy loss, Time projection chambers, FOS: Physical sciences, Particle detector, Nuclear physics, 03 medical and health sciences, neutrino: deep underground detector, 0103 physical sciences, ionization, Deep Underground Neutrino Experiment, High Energy Physics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], signal processing, activity report, Science & Technology, 010308 nuclear & particles physics, hep-ex, Large detector systems for particle and astroparticle physics, Time projection Chambers (TPC), 530 Physik, sensitivity, calibration, time projection chamber: liquid argon, Experimental High Energy Physics, Large detector systems for particle and astroparticle physic, single-phase), High Energy Physics::Experiment, photon: detector, particle identification, charged particle: irradiation, Beam (structure)
Abstract

The ProtoDUNE-SP detector was constructed and operated on the CERN Neutrino Platform. We thank the CERN management for providing the infrastructure for this experiment and gratefully acknowledge the support of the CERN EP, BE, TE, EN, IT and IPT Departments for NP04/ProtoDUNE-SP. This documentwas prepared by theDUNEcollaboration using the resources of the Fermi National Accelerator Laboratory (Fermilab), a U.S. Department of Energy, Office of Science, HEP User Facility. Fermilab is managed by Fermi Research Alliance, LLC (FRA), acting under Contract No. DE-AC02-07CH11359. This work was supported by CNPq, FAPERJ, FAPEG and FAPESP, Brazil; CFI, IPP and NSERC, Canada; CERN; MSMT, Czech Republic; ERDF, H2020-EU and MSCA, European Union; CNRS/IN2P3 and CEA, France; INFN, Italy; FCT, Portugal; NRF, South Korea; CAM, Fundacion "La Caixa" and MICINN, Spain; SERI and SNSF, Switzerland; TUBITAK, Turkey; The Royal Society and UKRI/STFC, United Kingdom; DOE and NSF, United States of America. This research used resources of the National Energy Research Scientific Computing Center (NERSC), a U.S. Department of Energy Office of Science User Facility operated under Contract No. DE-AC02-05CH11231., The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber with an active volume of 7.2× 6.1× 7.0 m3. It is installed at the CERN Neutrino Platform in a specially-constructed beam that delivers charged pions, kaons, protons, muons and electrons with momenta in the range 0.3 GeV/c to 7 GeV/c. Beam line instrumentation provides accurate momentum measurements and particle identification. The ProtoDUNE-SP detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment, and it incorporates full-size components as designed for that module. This paper describes the beam line, the time projection chamber, the photon detectors, the cosmic-ray tagger, the signal processing and particle reconstruction. It presents the first results on ProtoDUNE-SP's performance, including noise and gain measurements, dE/dx calibration for muons, protons, pions and electrons, drift electron lifetime measurements, and photon detector noise, signal sensitivity and time resolution measurements. The measured values meet or exceed the specifications for the DUNE far detector, in several cases by large margins. ProtoDUNE-SP's successful operation starting in 2018 and its production of large samples of high-quality data demonstrate the effectiveness of the single-phase far detector design., National Council for Scientific and Technological Development (CNPq), Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ), FAPEG, Brazil, Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Canada Foundation for Innovation, Natural Sciences and Engineering Research Council of Canada (NSERC), Ministry of Education, Youth & Sports - Czech Republic Czech Republic Government, European Union (EU), H2020-EU, French Atomic Energy Commission, Istituto Nazionale di Fisica Nucleare (INFN), NRF, South Korea, La Caixa Foundation, Spanish Government, Swiss National Science Foundation (SNSF), Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK), Royal Society of London, United States Department of Energy (DOE), National Science Foundation (NSF) DE-AC02-05CH11231, IPP, Canada, CERN, MSCA, Centre National de la Recherche Scientifique (CNRS), Portuguese Foundation for Science and Technology, CAM, Spain, SERI, Switzerland, UKRI/STFC, United Kingdom, DE-AC02-07CH11359

Published
2020

28. Long-baseline neutrino oscillation physics potential of the DUNE experiment: DUNE Collaboration

Author

M. Spanu, Xiaolu Ji, A. M. Szelc, Gareth J. Barker, C. Cattadori, J. Fried, J. Fowler, S. J. M. Peeters, S. Alonso Monsalve, G. Ge, Alexander Tapper, Thomas Strauss, B. Bhuyan, D. Vanegas Forero, A. L. Renshaw, A. P. Furmanski, P.T. Smith, D. Newhart, E. Raguzin, A. J. Roeth, R. Acciarri, Karol Lang, V. Savinov, P. Melas, A. Heavey, Grzegorz Deptuch, Kevin J. Kelly, D. Sgalaberna, R. LaZur, E. Pennacchio, F. W. Sippach, Kristian Harder, M. A. Uchida, J. Hewes, Sandro Palestini, K. Spurgeon, Sandip Pakvasa, F. Stocker, H. W. Sobel, A. Gallego-Ros, N. Buchanan, C. Grant, T. Li, T. Gamble, J. J. Grudzinski, N. Mauri, L. Molina Bueno, Jeremy Wolcott, Andrea Zani, M. J. Wilking, A. Olivares Del Campo, Joshua R. Klein, A. Hourlier, Jonas Rademacker, G. P. Zeller, A. Lawrence, D. Brailsford, M. Chalifour, I. Gil-Botella, R. Flight, H. Vieira de Souza, D. Redondo, S. R. Mishra, Paola Sala, Joshua Barrow, John Marshall, K. Francis, S. Ravat, W. Mu, D. Marfatia, Vasundhara Singh, Ranjan Dharmapalan, S. Striganov, Laura Paulucci, Mario Campanelli, D. Cherdack, M. A. Ramirez Delgado, S. J. Brice, Nicolas Lurkin, Wayne A. Barkhouse, A. Filkins, D. Autiero, Poonam Mehta, Dave Sankey, J. Asaadi, E. Valencia, E. James, N.V. Mokhov, A. Booth, E. Hazen, Armin Karcher, D. Smargianaki, S. Menary, P. C. de Holanda, J. Hugon, C. Brizzolari, M. Kirby, E. Kearns, A. C. Ezeribe, T. Lord, L. Zazueta, Daijin Kim, G.D. Barr, Junwei Huang, V. De Romeri, F. Piastra, C. Girerd, Christopher L. Marshall, A. Bitadze, Yichen Li, Alexander Deisting, H. Carranza, Milos Lokajicek, Roberto Gutiérrez, J. Pinzino, Janice L. Thompson, F. Kamiya, M. Wetstein, A. Cervera Villanueva, Robert Svoboda, L. C. J. Rice, L. Pasqualini, L. Di Giulio, J. Martin-Albo, H. Muramatsu, Z. Pavlovic, A. Falcone, R. Gran, A. A. Machado, R. Petti, M. Roda, Jianbei Liu, C. Vignoli, B. Rebel, Joleen Pater, David H. Adams, D. Caratelli, S. Martynenko, Ph. Lebrun, R. Staley, J. L. 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Ankowski, R. Milincic, P. Bernardini, L. Kashur, D. Edmunds, T. Stokes, A. Scaramelli, C. Bromberg, T. Safford, E. Tatar, L. Li, Utku Kose, Z. Djurcic, M. Leyton, M. E. Convery, D. Vargas, S. Green, K. Lande, Matthew L Strait, G. Barenboim, P. Guzowski, George Adamov, Jane Nachtman, E. Granados, B. Behera, Y. A. Ramachers, D. A. Martinez Caicedo, R. M. de Almeida, Yasar Onel, P. Lasorak, A. Izmaylov, J. K. Nelson, M. H. Shaevitz, N. Barros, Marcelo M. Guzzo, I. Caro Terrazas, R. Itay, K. Vaziri, F. Azfar, T. R. Junk, N. Poonthottathil, Christian Farnese, M. V. Diwan, Akitaka Ariga, Marvin L Marshak, A. Chiriacescu, T. Rehak, N. Martinez, L. Greenler, B. Guo, Frank Filthaut, J. Reichenbacher, S. Ventura, Riccardo Papaleo, P. Fernandez Menendez, J. Han, C. Y. Chi, M. Groh, D. J. Payne, C. Gotti, S. Biagi, Marco Adinolfi, M. Kordosky, L. Stanco, C. Jesús-Valls, Andrew Blake, L. Jiang, V. J. Guarino, J. Bremer, V. A. Kostelecký, L. Pickering, S. Manly, P. Hamilton, R. G. Van de Water, J. 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Barnes C., Barr G., Monarca J.B., Barros N., Barrow J.L., Bashyal A., Basque V., Bay F., Alba J.L.B., Beacom J.F., Bechetoille E., Behera B., Bellantoni L., Bellettini G., Bellini V., Beltramello O., Belver D., Benekos N., Neves F.B., Berger J., Berkman S., Bernardini P., Berner R.M., Berns H., Bertolucci S., Betancourt M., Bezawada Y., Bhattacharjee M., Bhuyan B., Biagi S., Bian J., Biassoni M., Biery K., Bilki B., Bishai M., Bitadze A., Blake A., Siffert B.B., Blaszczyk F.D.M., Blazey G.C., Blucher E., Boissevain J., Bolognesi S., Bolton T., Bonesini M., Bongrand M., Bonini F., Booth A., Booth C., Bordoni S., Borkum A., Boschi T., Bostan N., Bour P., Boyd S.B., Boyden D., Bracinik J., Braga D., Brailsford D., Brandt A., Bremer J., Brew C., Brianne E., Brice S.J., Brizzolari C., Bromberg C., Brooijmans G., Brooke J., Bross A., Brunetti G., Buchanan N., Budd H., Caiulo D., Calafiura P., Calcutt J., Calin M., Calvez S., Calvo E., Camilleri L., Caminata A., Campanelli M., Caratelli D., Carini G., Carlus B., Carniti P., Terrazas I.C., Carranza H., Castillo A., Castromonte C., Cattadori C., Cavalier F., Cavanna F., Centro S., Cerati G., Cervelli A., Villanueva A.C., Chalifour M., Chang C., Chardonnet E., Chatterjee A., Chattopadhyay S., Chaves J., Chen H., Chen M., Chen Y., Cherdack D., Chi C., Childress S., Chiriacescu A., Cho K., Choubey S., Christensen A., Christian D., Christodoulou G., Church E., Clarke P., Coan T.E., Cocco A.G., Coelho J.A.B., Conley E., Conrad J.M., Convery M., Corwin L., Cotte P., Cremaldi L., Cremonesi L., Crespo-Anadon J.I., Cristaldo E., Cross R., Cuesta C., Cui Y., Cussans D., Dabrowski M., Motta H., Da Silva Peres L., David C., David Q., Davies G.S., Davini S., Dawson J., De K., De Almeida R.M., Debbins P., De Bonis I., Decowski M.P., de Gouvea A., De Holanda P.C., De Icaza Astiz I.L., Deisting A., De Jong P., Delbart A., Delepine D., Delgado M., Dell'Acqua A., De Lurgio P., de Mello Neto J.R.T., DeMuth D.M., Dennis S., Densham C., Deptuch G., De Roeck A., De Romeri V., De Vries J.J., Dharmapalan R., Dias M., Diaz F., Diaz J.S., Domizio S.D., Giulio L.D., Ding P., Noto L.D., Distefano C., Diurba R., Diwan M., Djurcic Z., Dokania N., Dolinski M.J., Domine L., Douglas D., Drielsma F., Duchesneau D., Duffy K., Dunne P., Durkin T., Duyang H., Dvornikov O., Dwyer D.A., Dyshkant A.S., Eads M., Edmunds D., Eisch J., Emery S., Ereditato A., Escobar C.O., Sanchez L.E., Evans J.J., Ewart E., Ezeribe A.C., Fahey K., Falcone A., Farnese C., Farzan Y., Felix J., Fernandez-Martinez E., Menendez P.F., Ferraro F., Fields L., Filkins A., Filthaut F., Fitzpatrick R.S., Flanagan W., Fleming B., Flight R., Fowler J., Fox W., Franc J., Francis K., Franco D., Freeman J., Freestone J., Fried J., Friedland A., Fuess S., Furic I., Furmanski A.P., Gago A., Gallagher H., Gallego-Ros A., Gallice N., Galymov V., Gamberini E., Gamble T., Gandhi R., Gandrajula R., Gao S., Garcia-Gamez D., Garcia-Peris M.A., Gardiner S., Gastler D., Ge G., Gelli B., Gendotti A., Gent S., Ghorbani-Moghaddam Z., Gibin D., Gil-Botella I., Girerd C., Giri A.K., Gnani D., Gogota O., Gold M., Gollapinni S., Gollwitzer K., Gomes R.A., Bermeo L.V.G., Fajardo L.S.G., Gonnella F., Gonzalez-Cuevas J.A., Goodman M.C., Goodwin O., Goswami S., Gotti C., Goudzovski E., Grace C., Graham M., Gramellini E., Gran R., Granados E., Grant A., Grant C., Gratieri D., Green P., Green S., Greenler L., Greenwood M., Greer J., Griffith W.C., Groh M., Grudzinski J., Grzelak K., Gu W., Guarino V., Guenette R., Guglielmi A., Guo B., Guthikonda K.K., Gutierrez R., Guzowski P., Guzzo M.M., Gwon S., Habig A., Hackenburg A., Hadavand H., Haenni R., Hahn A., Haigh J., Haiston J., Hamernik T., Hamilton P., Han J., Harder K., Harris D.A., Hartnell J., Hasegawa T., Hatcher R., Hazen E., Heavey A., Heeger K.M., Heise J., Hennessy K., Henry S., Morquecho M.A.H., Herner K., Hertel L., Hesam A.S., Hewes J., Higuera A., Hill T., Hillier S.J., Himmel A., Hoff J., Hohl C., Holin A., Hoppe E., Horton-Smith G.A., Hostert M., Hourlier A., Howard B., Howell R., Huang J., Hugon J., Iles G., Ilic N., Iliescu A.M., Illingworth R., Ioannisian A., Itay R., Izmaylov A., James E., Jargowsky B., Jediny F., Jesus-Valls C., Ji X., Jiang L., Jimenez S., Jipa A., Joglekar A., Johnson C., Johnson R., Jones B., Jones S., Jung C.K., Junk T., Jwa Y., Kabirnezhad M., Kaboth A., Kadenko I., Kamiya F., Karagiorgi G., Karcher A., Karolak M., Karyotakis Y., Kasai S., Kasetti S.P., Kashur L., Kazaryan N., Kearns E., Keener P., Kelly K.J., Kemp E., Ketchum W., Kettell S.H., Khabibullin M., Khotjantsev A., Khvedelidze A., Kim D., King B., Kirby B., Kirby M., Klein J., Koehler K., Koerner L.W., Kohn S., Koller P.P., Kordosky M., Kosc T., Kose U., Kostelecky V.A., Kothekar K., Krennrich F., Kreslo I., Kudenko Y., Kudryavtsev V.A., Kulagin S., Kumar J., Kumar R., Kuruppu C., Kus V., Kutter T., Lambert A., Lande K., Lane C.E., Lang K., Langford T., Lasorak P., Last D., Lastoria C., Laundrie A., Lawrence A., Lazanu I., LaZur R., Le T., Learned J., LeBrun P., Miotto G.L., Lehnert R., de Oliveira M.A.L., Leitner M., Leyton M., Li L., Li S., Li S.W., Li T., Li Y., Liao H., Lin C.S., Lin S., Lister A., Littlejohn B.R., Liu J., Lockwitz S., Loew T., Lokajicek M., Lomidze I., Long K., Loo K., Lorca D., Lord T., LoSecco J.M., Louis W.C., Luk K.B., Luo X., Lurkin N., Lux T., Luzio V.P., MacFarland D., Machado A.A., Machado P., Macias C.T., Macier J.R., Maddalena A., Madigan P., Magill S., Mahn K., Maio A., Maloney J.A., Mandrioli G., Maneira J., Manenti L., Manly S., Mann A., Manolopoulos K., Plata M.M., Marchionni A., Marciano W., Marfatia D., Mariani C., Maricic J., Marinho F., Marino A.D., Marshak M., Marshall C., Marshall J., Marteau J., Martin-Albo J., Martinez N., Caicedo D.A.M., Martynenko S., Mason K., Mastbaum A., Masud M., Matsuno S., Matthews J., Mauger C., Mauri N., Mavrokoridis K., Mazza R., Mazzacane A., Mazzucato E., McCluskey E., McConkey N., McFarland K.S., McGrew C., McNab A., Mefodiev A., Mehta P., Melas P., Mellinato M., Mena O., Menary S., Mendez H., Menegolli A., Meng G., Messier M.D., Metcalf W., Mewes M., Meyer H., Miao T., Michna G., Miedema T., Migenda J., Milincic R., Miller W., Mills J., Milne C., Mineev O., Miranda O.G., Miryala S., Mishra C.S., Mishra S.R., Mislivec A., Mladenov D., Mocioiu I., Moffat K., Moggi N., Mohanta R., Mohayai T.A., Mokhov N., Molina J., Bueno L.M., Montanari A., Montanari C., Montanari D., Zetina L.M.M., Moon J., Mooney M., Moor A., Moreno D., Morgan B., Morris C., Mossey C., Motuk E., Moura C.A., Mousseau J., Mu W., Mualem L., Mueller J., Muether M., Mufson S., Muheim F., Muir A., Mulhearn M., Muramatsu H., Murphy S., Musser J., Nachtman J., Nagu S., Nalbandyan M., Nandakumar R., Naples D., Narita S., Navas-Nicolas D., Nayak N., Nebot-Guinot M., Necib L., Negishi K., Nelson J.K., Nesbit J., Nessi M., Newbold D., Newcomer M., Newhart D., Nichol R., Niner E., Nishimura K., Norman A., Norrick A., Northrop R., Novella P., Nowak J.A., Oberling M., Campo A.O.D., Olivier A., Onel Y., Onishchuk Y., Ott J., Pagani L., Pakvasa S., Palamara O., Palestini S., Paley J.M., Pallavicini M., Palomares C., Pantic E., Paolone V., Papadimitriou V., Papaleo R., Papanestis A., Paramesvaran S., Parke S., Parsa Z., Parvu M., Pascoli S., Pasqualini L., Pasternak J., Pater J., Patrick C., Patrizii L., Patterson R.B., Patton S.J., Patzak T., Paudel A., Paulos B., Paulucci L., Pavlovic Z., Pawloski G., Payne D., Pec V., Peeters S.J.M., Penichot Y., Pennacchio E., Penzo A., Peres O.L.G., Perry J., Pershey D., Pessina G., Petrillo G., Petta C., Petti R., Piastra F., Pickering L., Pietropaolo F., Pillow J., Pinzino J., Plunkett R., Poling R., Pons X., Poonthottathil N., Pordes S., Potekhin M., Potenza R., Potukuchi B.V.K.S., Pozimski J., Pozzato M., Prakash S., Prakash T., Prince S., Prior G., Pugnere D., Qi K., Qian X., Raaf J.L., Raboanary R., Radeka V., Rademacker J., Radics B., Rafique A., Raguzin E., Rai M., Rajaoalisoa M., Rakhno I., Rakotondramanana H.T., Rakotondravohitra L., Ramachers Y.A., Rameika R., Delgado M.A.R., Ramson B., Rappoldi A., Raselli G., Ratoff P., Ravat S., Razafinime H., Real J.S., Rebel B., Redondo D., Reggiani-Guzzo M., Rehak T., Reichenbacher J., Reitzner S.D., Renshaw A., Rescia S., Resnati F., Reynolds A., Riccobene G., Rice L.C.J., Rielage K., Rigaut Y., Rivera D., Rochester L., Roda M., Rodrigues P., Alonso M.J.R., Rondon J.R., Roeth A.J., Rogers H., Rosauro-Alcaraz S., Rossella M., Rout J., Roy S., Rubbia A., Rubbia C., Russell B., Russell J., Ruterbories D., Saakyan R., Sacerdoti S., Safford T., Sahu N., Sala P., Samios N., Sanchez M.C., Sanders D.A., Sankey D., Santana S., Santos-Maldonado M., Saoulidou N., Sapienza P., Sarasty C., Sarcevic I., Savage G., Savinov V., Scaramelli A., Scarff A., Scarpelli A., Schaffer T., Schellman H., Schlabach P., Schmitz D., Scholberg K., Schukraft A., Segreto E., Sensenig J., Seong I., Sergi A., Sergiampietri F., Sgalaberna D., Shaevitz M.H., Shafaq S., Shamma M., Sharma H.R., Sharma R., Shaw T., Shepherd-Themistocleous C., Shin S., Shooltz D., Shrock R., Simard L., Simos N., Sinclair J., Sinev G., Singh J., Singh V., Sipos R., Sippach F.W., Sirri G., Sitraka A., Siyeon K., Smargianaki D., Smith A., Smith E., Smith P., Smolik J., Smy M., Snopok P., Nunes M.S., Sobel H., Soderberg M., Salinas C.J.S., Soldner-Rembold S., Solomey N., Solovov V., Sondheim W.E., Sorel M., Soto-Oton J., Sousa A., Soustruznik K., Spagliardi F., Spanu M., Spitz J., Spooner N.J.C., Spurgeon K., Staley R., Stancari M., Stanco L., Steiner H.M., Stewart J., Stillwell B., Stock J., Stocker F., Stokes T., Strait M., Strauss T., Striganov S., Stuart A., Summers D., Surdo A., Susic V., Suter L., Sutera C.M., Svoboda R., Szczerbinska B., Szelc A.M., Talaga R., Tanaka H.A., Oregui B.T., Tapper A., Tariq S., Tatar E., Tayloe R., Teklu A.M., Tenti M., Terao K., Ternes C.A., Terranova F., Testera G., Thea A., Thompson J.L., Thorn C., Timm S.C., Tonazzo A., Torti M., Tortola M., Tortorici F., Totani D., Toups M., Touramanis C., Trevor J., Trzaska W.H., Tsai Y.T., Tsamalaidze Z., Tsang K.V., Tsverava N., Tufanli S., Tull C., Tyley E., Tzanov M., Uchida M.A., Urheim J., Usher T., Vagins M.R., Vahle P., Valdiviesso G.A., Valencia E., Vallari Z., Valle J.W.F., Vallecorsa S., Van Berg R., Van de Water R.G., Forero D.V., Varanini F., Vargas D., Varner G., Vasel J., Vasseur G., Vaziri K., Ventura S., Verdugo A., Vergani S., Vermeulen M.A., Verzocchi M., de Souza H.V., Vignoli C., Vilela C., Viren B., Vrba T., Wachala T., Waldron A.V., Wallbank M., Wang H., Wang J., Wang Y., Warburton K., Warner D., Wascko M., Waters D., Watson A., Weatherly P., Weber A., Weber M., Wei H., Weinstein A., Wenman D., Wetstein M., While M.R., White A., Whitehead L.H., Whittington D., Wilking M.J., Wilkinson C., Williams Z., Wilson F., Wilson R.J., Wolcott J., Wongjirad T., Wood K., Wood L., Worcester E., Worcester M., Wret C., Wu W., Xiao Y., Yang G., Yang T., Yershov N., Yonehara K., Young T., Yu B., Yu J., Zaki R., Zalesak J., Zambelli L., Zamorano B., Zani A., Zazueta L., Zeller G.P., Zennamo J., Zeug K., Zhang C., Zhao M., Zhivun E., Zhu G., Zimmerman E.D., Zito M., Zucchelli S., Zuklin J., Zutshi V., Zwaska R., Abi, B., Acciarri, R., Acero, M. 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M., Berns, H., Bertolucci, S., Betancourt, M., Bezawada, Y., Bhattacharjee, M., Bhuyan, B., Biagi, S., Bian, J., Biassoni, M., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Siffert, B. B., Blaszczyk, F. D. M., Blazey, G. C., Blucher, E., Boissevain, J., Bolognesi, S., Bolton, T., Bonesini, M., Bongrand, M., Bonini, F., Booth, A., Booth, C., Bordoni, S., Borkum, A., Boschi, T., Bostan, N., Bour, P., Boyd, S. B., Boyden, D., Bracinik, J., Braga, D., Brailsford, D., Brandt, A., Bremer, J., Brew, C., Brianne, E., Brice, S. J., Brizzolari, C., Bromberg, C., Brooijmans, G., Brooke, J., Bross, A., Brunetti, G., Buchanan, N., Budd, H., Caiulo, D., Calafiura, P., Calcutt, J., Calin, M., Calvez, S., Calvo, E., Camilleri, L., Caminata, A., Campanelli, M., Caratelli, D., Carini, G., Carlus, B., Carniti, P., Terrazas, I. C., Carranza, H., Castillo, A., Castromonte, C., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cervelli, A., Villanueva, A. C., Chalifour, M., Chang, C., Chardonnet, E., Chatterjee, A., Chattopadhyay, S., Chaves, J., Chen, H., Chen, M., Chen, Y., Cherdack, D., Chi, C., Childress, S., Chiriacescu, A., Cho, K., Choubey, S., Christensen, A., Christian, D., Christodoulou, G., Church, E., Clarke, P., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Conley, E., Conrad, J. M., Convery, M., Corwin, L., Cotte, P., Cremaldi, L., Cremonesi, L., Crespo-Anadon, J. I., Cristaldo, E., Cross, R., Cuesta, C., Cui, Y., Cussans, D., Dabrowski, M., Motta, H., Da Silva Peres, L., David, C., David, Q., Davies, G. S., Davini, S., Dawson, J., De, K., De Almeida, R. M., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvea, A., De Holanda, P. C., De Icaza Astiz, I. L., Deisting, A., De Jong, P., Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., De Lurgio, P., de Mello Neto, J. R. T., Demuth, D. M., Dennis, S., Densham, C., Deptuch, G., De Roeck, A., De Romeri, V., De Vries, J. J., Dharmapalan, R., Dias, M., Diaz, F., Diaz, J. S., Domizio, S. D., Giulio, L. D., Ding, P., Noto, L. D., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Dokania, N., Dolinski, M. J., Domine, L., Douglas, D., Drielsma, F., Duchesneau, D., Duffy, K., Dunne, P., Durkin, T., Duyang, H., Dvornikov, O., Dwyer, D. A., Dyshkant, A. S., Eads, M., Edmunds, D., Eisch, J., Emery, S., Ereditato, A., Escobar, C. O., Sanchez, L. E., Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Falcone, A., Farnese, C., Farzan, Y., Felix, J., Fernandez-Martinez, E., Menendez, P. F., Ferraro, F., Fields, L., Filkins, A., Filthaut, F., Fitzpatrick, R. S., Flanagan, W., Fleming, B., Flight, R., Fowler, J., Fox, W., Franc, J., Francis, K., Franco, D., Freeman, J., Freestone, J., Fried, J., Friedland, A., Fuess, S., Furic, I., Furmanski, A. P., Gago, A., Gallagher, H., Gallego-Ros, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Gandhi, R., Gandrajula, R., Gao, S., Garcia-Gamez, D., Garcia-Peris, M. A., Gardiner, S., Gastler, D., Ge, G., Gelli, B., Gendotti, A., Gent, S., Ghorbani-Moghaddam, Z., Gibin, D., Gil-Botella, I., Girerd, C., Giri, A. K., Gnani, D., Gogota, O., Gold, M., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. V. G., Fajardo, L. S. G., Gonnella, F., Gonzalez-Cuevas, J. A., Goodman, M. C., Goodwin, O., Goswami, S., Gotti, C., Goudzovski, E., Grace, C., Graham, M., Gramellini, E., Gran, R., Granados, E., Grant, A., Grant, C., Gratieri, D., Green, P., Green, S., Greenler, L., Greenwood, M., Greer, J., Griffith, W. C., Groh, M., Grudzinski, J., Grzelak, K., Gu, W., Guarino, V., Guenette, R., Guglielmi, A., Guo, B., Guthikonda, K. K., Gutierrez, R., Guzowski, P., Guzzo, M. M., Gwon, S., Habig, A., Hackenburg, A., Hadavand, H., Haenni, R., Hahn, A., Haigh, J., Haiston, J., Hamernik, T., Hamilton, P., Han, J., Harder, K., Harris, D. A., Hartnell, J., Hasegawa, T., Hatcher, R., Hazen, E., Heavey, A., Heeger, K. M., Heise, J., Hennessy, K., Henry, S., Morquecho, M. A. H., Herner, K., Hertel, L., Hesam, A. S., Hewes, J., Higuera, A., Hill, T., Hillier, S. J., Himmel, A., Hoff, J., Hohl, C., Holin, A., Hoppe, E., Horton-Smith, G. A., Hostert, M., Hourlier, A., Howard, B., Howell, R., Huang, J., Hugon, J., Iles, G., Ilic, N., Iliescu, A. M., Illingworth, R., Ioannisian, A., Itay, R., Izmaylov, A., James, E., Jargowsky, B., Jediny, F., Jesus-Valls, C., Ji, X., Jiang, L., Jimenez, S., Jipa, A., Joglekar, A., Johnson, C., Johnson, R., Jones, B., Jones, S., Jung, C. K., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A., Kadenko, I., Kamiya, F., Karagiorgi, G., Karcher, A., Karolak, M., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Kazaryan, N., Kearns, E., Keener, P., Kelly, K. J., Kemp, E., Ketchum, W., Kettell, S. H., Khabibullin, M., Khotjantsev, A., Khvedelidze, A., Kim, D., King, B., Kirby, B., Kirby, M., Klein, J., Koehler, K., Koerner, L. W., Kohn, S., Koller, P. 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M., Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marinho, F., Marino, A. D., Marshak, M., Marshall, C., Marshall, J., Marteau, J., Martin-Albo, J., Martinez, N., Caicedo, D. A. M., Martynenko, S., Mason, K., Mastbaum, A., Masud, M., Matsuno, S., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mazza, R., Mazzacane, A., Mazzucato, E., Mccluskey, E., Mcconkey, N., Mcfarland, K. S., Mcgrew, C., Mcnab, A., Mefodiev, A., Mehta, P., Melas, P., Mellinato, M., Mena, O., Menary, S., Mendez, H., Menegolli, A., Meng, G., Messier, M. D., Metcalf, W., Mewes, M., Meyer, H., Miao, T., Michna, G., Miedema, T., Migenda, J., Milincic, R., Miller, W., Mills, J., Milne, C., Mineev, O., Miranda, O. G., Miryala, S., Mishra, C. S., Mishra, S. R., Mislivec, A., Mladenov, D., Mocioiu, I., Moffat, K., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J., Bueno, L. M., Montanari, A., Montanari, C., Montanari, D., Zetina, L. M. M., Moon, J., Mooney, M., Moor, A., Moreno, D., Morgan, B., Morris, C., Mossey, C., Motuk, E., Moura, C. A., Mousseau, J., Mu, W., Mualem, L., Mueller, J., Muether, M., Mufson, S., Muheim, F., Muir, A., Mulhearn, M., Muramatsu, H., Murphy, S., Musser, J., Nachtman, J., Nagu, S., Nalbandyan, M., Nandakumar, R., Naples, D., Narita, S., Navas-Nicolas, D., Nayak, N., Nebot-Guinot, M., Necib, L., Negishi, K., Nelson, J. K., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Newhart, D., Nichol, R., Niner, E., Nishimura, K., Norman, A., Norrick, A., Northrop, R., Novella, P., Nowak, J. A., Oberling, M., Campo, A. O. D., Olivier, A., Onel, Y., Onishchuk, Y., Ott, J., Pagani, L., Pakvasa, S., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Pantic, E., Paolone, V., Papadimitriou, V., Papaleo, R., Papanestis, A., Paramesvaran, S., Parke, S., Parsa, Z., Parvu, M., Pascoli, S., Pasqualini, L., Pasternak, J., Pater, J., Patrick, C., Patrizii, L., Patterson, R. B., Patton, S. J., Patzak, T., Paudel, A., Paulos, B., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Peeters, S. J. M., Penichot, Y., Pennacchio, E., Penzo, A., Peres, O. L. G., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Piastra, F., Pickering, L., Pietropaolo, F., Pillow, J., Pinzino, J., Plunkett, R., Poling, R., Pons, X., Poonthottathil, N., Pordes, S., Potekhin, M., Potenza, R., Potukuchi, B. V. K. S., Pozimski, J., Pozzato, M., Prakash, S., Prakash, T., Prince, S., Prior, G., Pugnere, D., Qi, K., Qian, X., Raaf, J. L., Raboanary, R., Radeka, V., Rademacker, J., Radics, B., Rafique, A., Raguzin, E., Rai, M., Rajaoalisoa, M., Rakhno, I., Rakotondramanana, H. T., Rakotondravohitra, L., Ramachers, Y. A., Rameika, R., Delgado, M. A. R., Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Ravat, S., Razafinime, H., Real, J. S., Rebel, B., Redondo, D., Reggiani-Guzzo, M., Rehak, T., Reichenbacher, J., Reitzner, S. D., Renshaw, A., Rescia, S., Resnati, F., Reynolds, A., Riccobene, G., Rice, L. C. J., Rielage, K., Rigaut, Y., Rivera, D., Rochester, L., Roda, M., Rodrigues, P., Alonso, M. J. R., Rondon, J. R., Roeth, A. J., Rogers, H., Rosauro-Alcaraz, S., Rossella, M., Rout, J., Roy, S., Rubbia, A., Rubbia, C., Russell, B., Russell, J., Ruterbories, D., Saakyan, R., Sacerdoti, S., Safford, T., Sahu, N., Sala, P., Samios, N., Sanchez, M. C., Sanders, D. A., Sankey, D., Santana, S., Santos-Maldonado, M., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Savage, G., Savinov, V., Scaramelli, A., Scarff, A., Scarpelli, A., Schaffer, T., Schellman, H., Schlabach, P., Schmitz, D., Scholberg, K., Schukraft, A., Segreto, E., Sensenig, J., Seong, I., Sergi, A., Sergiampietri, F., Sgalaberna, D., Shaevitz, M. H., Shafaq, S., Shamma, M., Sharma, H. R., Sharma, R., Shaw, T., Shepherd-Themistocleous, C., Shin, S., Shooltz, D., Shrock, R., Simard, L., Simos, N., Sinclair, J., Sinev, G., Singh, J., Singh, V., Sipos, R., Sippach, F. W., Sirri, G., Sitraka, A., Siyeon, K., Smargianaki, D., Smith, A., Smith, E., Smith, P., Smolik, J., Smy, M., Snopok, P., Nunes, M. S., Sobel, H., Soderberg, M., Salinas, C. J. S., Soldner-Rembold, S., Solomey, N., Solovov, V., Sondheim, W. E., Sorel, M., Soto-Oton, J., Sousa, A., Soustruznik, K., Spagliardi, F., Spanu, M., Spitz, J., Spooner, N. J. C., Spurgeon, K., Staley, R., Stancari, M., Stanco, L., Steiner, H. M., Stewart, J., Stillwell, B., Stock, J., Stocker, F., Stokes, T., Strait, M., Strauss, T., Striganov, S., Stuart, A., Summers, D., Surdo, A., Susic, V., Suter, L., Sutera, C. M., Svoboda, R., Szczerbinska, B., Szelc, A. M., Talaga, R., Tanaka, H. A., Oregui, B. T., Tapper, A., Tariq, S., Tatar, E., Tayloe, R., Teklu, A. M., Tenti, M., Terao, K., Ternes, C. A., Terranova, F., Testera, G., Thea, A., Thompson, J. L., Thorn, C., Timm, S. C., Tonazzo, A., Torti, M., Tortola, M., Tortorici, F., Totani, D., Toups, M., Touramanis, C., Trevor, J., Trzaska, W. H., Tsai, Y. T., Tsamalaidze, Z., Tsang, K. V., Tsverava, N., Tufanli, S., Tull, C., Tyley, E., Tzanov, M., Uchida, M. A., Urheim, J., Usher, T., Vagins, M. R., Vahle, P., Valdiviesso, G. A., Valencia, E., Vallari, Z., Valle, J. W. F., Vallecorsa, S., Van Berg, R., Van de Water, R. G., Forero, D. V., Varanini, F., Vargas, D., Varner, G., Vasel, J., Vasseur, G., Vaziri, K., Ventura, S., Verdugo, A., Vergani, S., Vermeulen, M. A., Verzocchi, M., de Souza, H. V., Vignoli, C., Vilela, C., Viren, B., Vrba, T., Wachala, T., Waldron, A. V., Wallbank, M., Wang, H., Wang, J., Wang, Y., Warburton, K., Warner, D., Wascko, M., Waters, D., Watson, A., Weatherly, P., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenman, D., Wetstein, M., While, M. R., White, A., Whitehead, L. H., Whittington, D., Wilking, M. J., Wilkinson, C., Williams, Z., Wilson, F., Wilson, R. J., Wolcott, J., Wongjirad, T., Wood, K., Wood, L., Worcester, E., Worcester, M., Wret, C., Wu, W., Xiao, Y., Yang, G., Yang, T., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, J., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G. P., Zennamo, J., Zeug, K., Zhang, C., Zhao, M., Zhivun, E., Zhu, G., Zimmerman, E. D., Zito, M., Zucchelli, S., Zuklin, J., Zutshi, V., and Zwaska, R.

Subjects
Physics and Astronomy (miscellaneous), Physics::Instrumentation and Detectors, 01 natural sciences, Particle detector, Physics, Particles & Fields, Nuclear physics, neutrino, 0103 physical sciences, Neutrino oscillations, neutrino physiscs, Deep Underground Neutrino Experiment, Deep Underground Neutrino Experiment, Neutrino oscillation experiment, DISTRIBUTIONS, Fermilab, High Energy Physics, LEPTON SCATTERING, 010306 general physics, Neutrino oscillation, Engineering (miscellaneous), Physics, Science & Technology, 010308 nuclear & particles physics, Detector, High Energy Physics::Phenomenology, Neutrino detector, Physical Sciences, High Energy Physics::Experiment, Neutrino, Lepton
Abstract

The sensitivity of the Deep Underground Neutrino Experiment (DUNE) to neutrino oscillation is determined, based on a full simulation, reconstruction, and event selection of the far detector and a full simulation and parameterized analysis of the near detector. Detailed uncertainties due to the flux prediction, neutrino interaction model, and detector effects are included. DUNE will resolve the neutrino mass ordering to a precision of 5$$\sigma $$ σ , for all $$\delta _{\mathrm{CP}}$$ δ CP values, after 2 years of running with the nominal detector design and beam configuration. It has the potential to observe charge-parity violation in the neutrino sector to a precision of 3$$\sigma $$ σ (5$$\sigma $$ σ ) after an exposure of 5 (10) years, for 50% of all $$\delta _{\mathrm{CP}}$$ δ CP values. It will also make precise measurements of other parameters governing long-baseline neutrino oscillation, and after an exposure of 15 years will achieve a similar sensitivity to $$\sin ^{2} 2\theta _{13}$$ sin 2 2 θ 13 to current reactor experiments.

Published
2020

29. Produção de micropartículas bidimensionais (2D) com geometria controlada usando plataformas de elevado contraste de molhabilidade

Author

Neto, Mafalda Dias de Campos, Oliveira, Mariana Braga de, and Mano, João

Subjects
Advanced cell carriers, Wettable-dewettable contrasts, Microparticle design, Ultra-thin polymeric particles, Patterned surfaces
Abstract

For several decades microparticles have been exclusively and extensively explored as spherical drug delivery vehicles and large-scale cell expansion carriers. More recently, microparticulate structures gained interest in broader bioengineering fields, integrating a myriad of strategies that include bottom-up tissue engineering, three-dimensional (3D) bioprinting, and development of tissue/disease models. The concept of bulk spherical micrometric particles as adequate supports for cell culture has been challenged, and systems with finely tuned geometric designs and (bio)chemical/physical features are current key players in impacting technologies. In this sense, the discovery of twodimensional (2D) materials led to the breakthrough of a multitude of different low dimensional structures with very unique properties, namely (i) high surface areato-volume ratio, (ii) sub-micrometer thickness, (iii) heterofunctionality and (iv) non-covalent adhesiveness, which surpass their bulk counterparts. Although their development regarding tunable lateral-dimensions and geometries remains challenging, pre-patterned platforms had gain significant attention in addressing such drawback. Herein, resorting to wettability contrast patterned surfaces, different nanometer-thick particles of various sizes and geometries (e.g. squares, circles, triangles, hexagons) with high precision and definition were developed. These ultrathin quasi-2D polymeric microparticles in contact with cells allow the generation of gravity-enforced human adipose-derived stems cells spheroids without impairing their natural morphology. Cell culture for 3 days maintain cells viable, metabolically active and an increase in the release of angiogenic factors, namely VEGF. Durante várias décadas, as micropartículas têm sido usadas como veículos esféricos para a entrega controlada de fármacos ou mesmo como carriers para a expansão celular em larga escala. Mais recentemente, estas estruturas têm recebido uma grande atenção em diversas áreas da bioengenharia, podendo integrar uma vasta variedade de estratégias que incluem, não só, a engenharia de tecidos, como também bioprinting 3D ou mesmo o desenvolvimento de modelos de tecidos/doença. O conceito de micropartículas esféricas como suportes adequados à cultura e expansão celular têm sido contestados se serão a abordagem mais adequada. Para tal, sistemas que sejam capazes de alterar não só a geometria, mas também modelar as propriedades (bio)químicas e físicas, são fatores determinantes em diversas tecnologias. Neste sentido, a descoberta de materiais 2D levou a um rápido aparecimento de uma diversidade de estruturas que exibem propriedades únicas, como o (i) elevado rácio superfície de área-volume, (ii) espessuras à escala sub-micrométrica, (iii) a possibilidade de serem heterofuncionalizadas e ainda (iv) propriedades adesivas não covalentes, que se distinguem grandemente dos seus equivalentes 3D. Embora o desenvolvimento destas estruturas com dimensões laterais e geometrias flexíveis permaneça um desafio, plataformas baseadas em padrões têm permitido ultrapassar esta desvantagem. Por esta razão, neste trabalho, superfícies com elevado contraste de molhabilidade foram utilizadas para o fabrico de partículas com diferentes tamanhos e formas (quadrados, círculos, triângulos e hexágonos), apresentando uma espessura à escala nanométrica. Ademais, estas partículas ultra-finas quando em contacto com células estaminais derivadas do tecido adiposo permitem a formação de esferóides sem impedir a sua normal agregação e morfologia. As células mantiveram-se viáveis e metabolicamente ativas durante os 3 dias de cultura, e verificou-se ainda, um aumento na libertação de fatores angiogénicos (VEGF). Mestrado em Biotecnologia

Published
2019

31. Considerations when Measuring Biocatalyst Performance

Author

John M. Woodley and Mafalda Dias Gomes

Subjects
biocatalysis, Computer science, Stability (learning theory), Immobilized enzymes, Pharmaceutical Science, Turnover number, 010402 general chemistry, 01 natural sciences, Analytical Chemistry, lcsh:QD241-441, lcsh:Organic chemistry, enzyme kinetics, Drug Discovery, Process performance metrics, Physical and Theoretical Chemistry, enzyme stability, Productivity, turnover number, process performance metrics, Enzyme stability, Measure (data warehouse), 010405 organic chemistry, Enzyme kinetics, Organic Chemistry, Temperature, immobilized enzymes, Benchmarking, Concept Paper, Enzymes, Immobilized, 0104 chemical sciences, Kinetics, Chemistry (miscellaneous), Scalability, Biocatalysis, Molecular Medicine, Biological Assay, Biochemical engineering, Performance metric
Abstract

As biocatalysis matures, it becomes increasingly important to establish methods with which to measure biocatalyst performance. Such measurements are important to assess immobilization strategies, different operating modes, and reactor configurations, aside from comparing protein engineered variants and benchmarking against economic targets. While conventional measurement techniques focus on a single performance metric (such as the total turnover number), here, it is argued that three metrics (achievable product concentration, productivity, and enzyme stability) are required for an accurate assessment of scalability.

Published
2019

32. Oxygen Transfer vs. Enzyme Stability

Author

John M. Woodley, Mafalda Dias Gomes, Andreas S. Bommarius, Bettina Bommarius, Shelby R. Anderson, and Brent D. Feske

Subjects
Reaction rate, Bubble column, biology, Biocatalysis, Chemistry, biology.protein, NADH oxidase, Organic chemistry, Cover (algebra), General Chemistry, Alcohol dehydrogenase
Published
2019

33. Pole N-flation

Author

Alexander Westphal, Marco Scalisi, Jonathan Frazer, Ander Retolaza, and Mafalda Dias

Subjects
High Energy Physics - Theory, Nuclear and High Energy Physics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Scalar (mathematics), FOS: Physical sciences, Kinetic term, String theory, 01 natural sciences, Moduli, Theoretical physics, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology (hep-ph), 0103 physical sciences, Attractor, Supersymmetric Effective Theories, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, ddc:530, 010306 general physics, Axion, Physics, 010308 nuclear & particles physics, Supergravity, Inflaton, Cosmology of Theories beyond the SM, High Energy Physics - Phenomenology, High Energy Physics - Theory (hep-th), lcsh:QC770-798, Supergravity Models, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

A second order pole in the scalar kinetic term can lead to a class of inflation models with universal predictions referred to as pole inflation or $\alpha$-attractors. While this kinetic structure is ubiquitous in supergravity effective field theories, realising a consistent UV complete model in e.g. string theory is a non-trivial task. For one, one expects quantum corrections arising in the vicinity of the pole which may spoil the typical attractor dynamics. As a conservative estimate of the range of validity of supergravity models of pole inflation we employ the weak gravity conjecture (WGC). We find that this constrains the accessible part of the inflationary plateau by limiting the decay constant of the axion partner. For the original single complex field models, the WGC does not even allow the inflaton to reach the inflationary plateau region. We analyze if evoking the assistance of $N$ scalar fields from the open string moduli helps addressing these problems. Pole $N$-flation could improve radiative control by reducing the required range of each individual field. However, the WGC bound prohibiting pole inflation for a single such field persists even for a collective motion of $N$ such scalars if we impose the sublattice WGC. Finally, we outline steps towards an embedding of pole N-flation in type IIB string theory on fibred Calabi-Yau manifolds., Comment: LaTeX, 1+29 pages, 2 figures; v2: Stronger result from correcting an error in applying the N-dimensional convex hull condition; Discussion of weak gravity conjecture for models of fibre inflation moved to future work; References added; v3: Comments and references added. JHEP version

Published
2019
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35. Use of image analysis to understand enzyme stability in an aerated stirred reactor

Author

Thomas Martini Jørgensen, Mafalda Dias Gomes, Andreas Baum, Rayisa P. Moiseyenko, and John M. Woodley

Subjects
In situ, chemistry.chemical_element, Aerated stirred reactor, 010402 general chemistry, 01 natural sciences, Oxygen, Cofactor, Image analysis, Bioreactors, Enzyme Stability, Bioreactor, Image Processing, Computer-Assisted, Enzyme stability, chemistry.chemical_classification, biology, 010405 organic chemistry, NADPH Oxidases, Gas-liquid interface, 0104 chemical sciences, Enzyme, chemistry, Chemical engineering, Biocatalysis, Calibration, biology.protein, NAD+ kinase, Aeration, Algorithms, Biotechnology
Abstract

Efficient regeneration of NAD(P)+ cofactors is essential for large‐scale application of alcohol dehydrogenases due to the high cost and chemical instability of these cofactors. NAD(P)+ can be regenerated effectively using NAD(P)H oxidases that require molecular oxygen as a co‐substrate. In large‐scale biocatalytic processes, agitation and aeration are needed for sufficient oxygen transfer into the liquid phase, both of which have been shown to significantly increase the rate of enzyme deactivation. As such, the aim of this study was to identify the existence of a correlation between enzyme stability and gas‐liquid interfacial area inside the bioreactor. This was done by measuring gas‐liquid interfacial areas inside an aerated stirred reactor, using an in situ optical probe, and simultaneously measuring the kinetic stability of NAD(P)H oxidase. Following enzyme incubation at various power inputs and gas‐phase compositions, the residual activity was assessed and video samples were analysed through an image processing algorithm. Enzyme deactivation was found to be proportional to an increase in interfacial area up to a certain limit, where power input appears to have a higher impact. Furthermore, the presence of oxygen increased enzyme deactivation rates at low interfacial areas. The areas were validated with defined glass beads and found to be in the range of those in large‐scale bioreactors. Finally, a correlation between the enzyme half‐life and specific interfacial area was obtained. Therefore, we conclude that the method developed in this contribution can help to predict the behavior of biocatalyst stability under industrially relevant conditions, concerning specific gas‐liquid interfacial areas.

Published
2019

36. Bubble Column Enables Higher Reaction Rate for Deracemization of (R,S)‐1‐Phenylethanol with Coupled Alcohol Dehydrogenase/NADH Oxidase System

Author

Andreas S. Bommarius, Shelby R. Anderson, John M. Woodley, Mafalda Dias Gomes, Bettina Bommarius, and Brent D. Feske

Subjects
Bubble column, biology, Chemistry, General Chemistry, Gas-liquid interface, Combinatorial chemistry, Reaction rate, Deracemization, Biocatalysis, NADH oxidase, biology.protein, Alcohol dehydrogenase
Abstract

ne of the major drawbacks for many biocatalysts is their poor stability under industrial process conditions. A particularly interesting example is the supply of oxygen to biooxidation reactions, catalyzed by oxidases, oxygenases or alcohol dehydrogenases coupled with NAD(P)H (reduced nicotinamide adenine dinucleotide phosphate) oxidases, which all require the continuous supply of molecular oxygen as an oxidant or electron acceptor. Commonly, oxygen is supplied to the bioreactor by air sparging. To ensure sufficient oxygen transfer from the gas to the liquid phase, stirring is essential to disperse the gas bubbles and create high gas‐liquid interfacial area. Studies indicate that the presence of gas‐liquid interface induces enzyme deactivation by protein unfolding which then readily aggregates and can subsequently precipitate. This contribution has examined the effects of stirring and the presence of gas‐liquid interface on the kinetic stability of water‐forming NAD(P)H oxidase (NOX) (EC1.6.3.2). These effects were studied separately and a bubble column apparatus was successfully employed to investigate the influence of gas‐liquid interfaces on enzyme stability. Results showed that NOX deactivation increases in proportion to the gas‐liquid interfacial area. While air enhances the rate of stability loss compared to nitrogen, stirring causes faster loss of activity in comparison to a bubble column. Finally, deracemization of 1‐phenylethanol, using a coupled alcohol dehydrogenase /NADH oxidase system (ADH/NOX), proceeded with a higher rate in the bubble column than in quiescent or in a stirred solution, although, inactivation was also accelerated in the bubble column over a quiescent solution.

Published
2019

37. Scoping Biocatalyst Performance Using Reaction Trajectory Analysis

Author

John M. Woodley, Mafalda Dias Gomes, Mathias Nordblad, Hemalata Ramesh, and Murray Peter Meissner

Subjects
Reaction engine, Kinetic Characterization, 010405 organic chemistry, Computer science, Process development, Process (engineering), Mechanism (biology), Organic Chemistry, Stability (learning theory), Process Development, 010402 general chemistry, 01 natural sciences, Bottleneck, 0104 chemical sciences, Task (project management), Bottleneck Identification, Biocatalysis, Biochemical engineering, Physical and Theoretical Chemistry, Set (psychology)
Abstract

Process development for biocatalytic reactions is a complex task due to the required interaction of several different scientific disciplines. Additionally, there is a lack of standardized procedures for guiding development and for identifying the major process limitations in these systems. This work seeks to address this problem by providing a methodology based on a simple, systematic series of experiments. Application of the methodology helps identify the major bottleneck for process implementation, whether it be enzyme activity, enzyme stability, or substrate mass transfer. In addition, the underlying mechanism behind these limitations can also be inferred. The methodology is illustrated using a simulated reaction system and is also applied to three experimental case studies. This methodology provides a set of simple experiments that may be performed at an early stage of biocatalytic process development to guide effective improvement strategies, whether they be viaprotein engineering or reaction engineering. Ultimately, this should afford faster and more efficient implementation of biocatalysts in industrial processes.

Published
2018
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38. O contributo dos cinco sentidos para a comunicação internacional do turismo em Portugal

Author

Ana Mafalda Dias Franco and Faculdade de Economia

Subjects
Economia e gestão, Economics and Business, Economia e gestão [Ciências sociais], Economics and Business [Social sciences]
Abstract

Este estudo discute a importância dos cinco sentidos ao experienciar um destino, tornando possível a utilização de princípios de marketing sensorial no turismo A importância estratégica a nível internacional atribuída ao turismo nas últimas décadas fez com que este se tornasse um dos setores mais importantes da economia. A aposta no turismo tornou-se um fator de competitividade para os destinos turísticos como Portugal.Estudar as experiências sensoriais vivenciadas pelos turistas ao longo da sua visita a Portugal torna-se, então, essencial para encontrar novas formas de melhor comunicar/apresentar o país a nível internacional, com o objetivo de atrair e encantar um maior número de turistas. A imagem, o som, o sabor, a textura e o cheiro de um destino são cada vez mais evidentes para os estudos em turismo, uma vez que são variáveis que influenciam, consideravelmente, a preferência, motivação e comportamento dos indivíduos no processo de escolha do destino turístico. O objetivo deste estudo é compreender o papel dos cinco sentidos no turismo em Portugal, através do conhecimento das experiências sensoriais que os turistas de vários países mais valorizam quando visitam o país, recorrendo a uma metodologia qualitativa tendo por base uma análise netnográfica e uma análise quantitativa de conteúdo.

Published
2017

39. Seven Lessons from Manyfield Inflation in Random Potentials

Author

Jonathan Frazer, M.C. David Marsh, Mafalda Dias, Marsh, David [0000-0001-7271-4115], and Apollo - University of Cambridge Repository

Subjects
Inflation, string theory and cosmology, High Energy Physics - Theory, satellite: Planck, Cosmology and Nongalactic Astrophysics (astro-ph.CO), random [matrix model], media_common.quotation_subject, potential: random, FOS: Physical sciences, 01 natural sciences, scalar [potential], isocurvature, field theory [tachyon], symbols.namesake, 0103 physical sciences, model [inflation], physics of the early universe, ddc:530, Statistical physics, correlation function, Planck, inflation, 010306 general physics, random [potential], Eigenvalues and eigenvectors, media_common, Hyperparameter, Physics, 010308 nuclear & particles physics, potential: scalar, Scalar (physics), tachyon: field theory, saddle-point approximation, Astronomy and Astrophysics, Observable, matrix model: random, inflation: model, Tachyon, High Energy Physics - Theory (hep-th), symbols, Random matrix, statistical, Planck [satellite], Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Journal of cosmology and astroparticle physics 1801(01), 036 (2018). doi:10.1088/1475-7516/2018/01/036, We study inflation in models with many interacting fields subject to randomly generated scalar potentials. We use methods from non-equilibrium random matrix theory to construct the potentials and an adaption of the transport method to evolve the two-point correlators during inflation. This construction allows, for the first time, for an explicit study of models with up to 100 interacting fields supporting a period of approximately saddle-point inflation. We determine the statistical predictions for observables by generating over 30,000 models with 2-100 fields supporting at least 60 efolds of inflation. These studies lead us to seven lessons: i) Manyfield inflation is not single-field inflation, ii) The larger the number of fields, the simpler and sharper the predictions, iii) Planck compatibility is not rare, but future experiments may rule out this class of models, iv) The smoother the potentials, the sharper the predictions, v) Hyperparameters can transition from stiff to sloppy, vi) Despite tachyons, isocurvature can decay, vii) Eigenvalue repulsion drives the predictions. We conclude that many of the generic predictions of single-field inflation can be emergent features of complex inflation models., Published by IOP, London

Published
2017
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41. Scale-dependent bias from multiple-field inflation

Author

MAFALDA DIAS, Mafalda Dias, David Seery, and Raquel H Ribeiro

Subjects
Physics, Inflation (cosmology), High Energy Physics - Theory, Nuclear and High Energy Physics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Field (physics), 010308 nuclear & particles physics, Scalar (mathematics), FOS: Physical sciences, Observable, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Momentum, General Relativity and Quantum Cosmology, Classical mechanics, QB0980, High Energy Physics - Theory (hep-th), 0103 physical sciences, Halo effect, Statistical physics, 010306 general physics, Bispectrum, Scaling, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We provide a formula for the scaling behaviour of the inflationary bispectrum in the 'squeezed' limit where one momentum becomes much smaller than the other two. This determines the scaling of the halo bias at low wavenumber and will be an important observable for the next generation of galaxy surveys. Our formula allows it to be predicted for the first time for a generic inflationary model with multiple light, canonically-normalized scalar fields., Comment: 5 pages, 1 figure

Published
2013
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42. The curvature perturbation at second order

Author

Mafalda Dias, Joseph Elliston, David Seery, Jonathan Frazer, and David J. Mulryne

Subjects
High Energy Physics - Theory, Physics, Inflation (cosmology), Cosmology and Nongalactic Astrophysics (astro-ph.CO), media_common.quotation_subject, FOS: Physical sciences, Order (ring theory), Astronomy and Astrophysics, Observable, Curvature perturbation, General Relativity and Quantum Cosmology (gr-qc), General Relativity and Quantum Cosmology, Expression (mathematics), Universe, High Energy Physics - Theory (hep-th), QB0980, Cosmological perturbation theory, Wavenumber, Astrophysics - Cosmology and Nongalactic Astrophysics, Mathematical physics, media_common
Abstract

We give an explicit relation, up to second-order terms, between scalar-field fluctuations defined on spatially-flat slices and the curvature perturbation on uniform-density slices. This expression is a necessary ingredient for calculating observable quantities at second-order and beyond in multiple-field inflation. We show that traditional cosmological perturbation theory and the `separate universe' approach yield equivalent expressions for superhorizon wavenumbers, and in particular that all nonlocal terms can be eliminated from the perturbation-theory expressions., Comment: 16 pages, no figures. This is an author-created, un-copyedited version of an article published in JCAP. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at http://dx.doi.org/10.1088/1475-7516/2015/02/040. v3: Updated to match version published in JCAP

Published
2015

43. Chaotic inflation with kinetic alignment of axion fields

Author

Mafalda Dias, Jonathan Frazer, Thomas C. Bachlechner, and Liam McAllister

Subjects
Physics, Nuclear and High Energy Physics, 010308 nuclear & particles physics, Kinematics, Kinetic term, String theory, Kinetic energy, 01 natural sciences, Classical mechanics, Lattice (order), 0103 physical sciences, 010306 general physics, Eternal inflation, Axion, Eigenvalues and eigenvectors
Abstract

N-flation is a radiatively stable scenario for chaotic inflation in which the displacements of N≫1 axions with decay constants f1≤…≤fN

Published
2015

44. Thick Braneworlds and the Gibbons-Kallosh-Linde No-go Theorem in the Gauss-Bonnet Framework

Author

J. M. Hoff da Silva, Roldao da Rocha, and Mafalda Dias

Subjects
Physics, Theoretical physics, Dimension (vector space), Gauss–Bonnet theorem, No-go theorem, Brane cosmology, General Physics and Astronomy, FOS: Physical sciences, Context (language use), General Relativity and Quantum Cosmology (gr-qc), General Relativity and Quantum Cosmology
Abstract

The sum rules related to thick braneworlds are constructed, in order to encompass Gauss-Bonnet terms. The generation of thick branes is hence proposed in a periodic extra dimension scenario, what circumvents the Gibbons-Kallosh-Linde no-go theorem in this context., Comment: 6 pages, to appear in the EPL. arXiv admin note: text overlap with arXiv:1406.6324

Published
2015
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45. Large Scale Power Suppression in a Multifield Landscape

Author

Jonathan Frazer, Kepa Sousa, Mafalda Dias, and Jose J. Blanco-Pillado

Subjects
Physics, Inflation (cosmology), High Energy Physics - Theory, Cosmology and Nongalactic Astrophysics (astro-ph.CO), 010308 nuclear & particles physics, media_common.quotation_subject, Cosmic microwave background, Cosmic background radiation, Scalar (physics), FOS: Physical sciences, Astronomy and Astrophysics, Observable, Observable universe, Context (language use), 01 natural sciences, Universe, High Energy Physics - Theory (hep-th), 0103 physical sciences, Statistical physics, 010306 general physics, media_common, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Power suppression of the cosmic microwave background on the largest observable scales could provide valuable clues about the particle physics underlying inflation. Here we consider the prospect of power suppression in the context of the multifield landscape. Based on the assumption that our observable universe emerges from a tunnelling event and that the relevant features originate purely from inflationary dynamics, we find that the power spectrum not only contains information on single-field dynamics, but also places strong con- straints on all scalar fields present in the theory. We find that the simplest single-field models giving rise to power suppression do not generalise to multifield models in a straightforward way, as the resulting superhorizon evolution of the curvature perturbation tends to erase any power suppression present at horizon crossing. On the other hand, multifield effects do present a means of generating power suppression which to our knowledge has so far not been considered. We propose a mechanism to illustrate this, which we dub flume inflation., Comment: 22 pages plus appendices, 8 figures. Minor corrections to match JCAP published version

Published
2015
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46. Transport equations for the inflationary spectral index

Author

Mafalda Dias, MAFALDA DIAS, and David Seery

Subjects
Physics, High Energy Physics - Theory, Nuclear and High Energy Physics, Spectral index, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Spectral density, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Cosmology, Classical mechanics, High Energy Physics - Theory (hep-th), QB0980, Simple (abstract algebra), Statistical physics, Convection–diffusion equation, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present a simple and efficient method to compute the superhorizon evolution of the spectral index in multi-field inflationary models, using transport equation techniques. We illustrate the evolution of n_s with time for various interesting potentials., 6 pages; minor changes to match published version

Published
2012

47. Cosmology at the boundary of de Sitter using the dS/QFT correspondence

Author

Mafalda Dias and MAFALDA DIAS

Subjects
Physics, Inflation (cosmology), High Energy Physics - Theory, Nuclear and High Energy Physics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), De Sitter space, Boundary (topology), FOS: Physical sciences, Observable, General Relativity and Quantum Cosmology (gr-qc), Scale invariance, Cosmology, General Relativity and Quantum Cosmology, Theoretical physics, Classical mechanics, QB0980, High Energy Physics - Theory (hep-th), Limit (mathematics), de Sitter invariant special relativity, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Using the dS/QFT correspondence in the context of inflation allows for the study of interesting, otherwise inaccessible physics. In particular, by studying inflation via its dual field theory at the boundary of the de Sitter space, it may be possible to study a regime of strongly coupled gravity at early times. The purpose of this work is to completely express cosmological observables in terms of the free parameters of a dual field theory and to compare them with CMB data. In this way, constraints on the observational parameters constrains the validity of the strongly coupled inflation picture by imposing limits on the parameters of the field theory. The fit with data defines a limit for the consistency and validity of the approach taken and shows that, within this limit, the model is almost unconstrained, but quite predictive, producing power spectra of density perturbations extremely near scale invariance., Comment: 10 pages, 7 figures, minor changes to match published version

Published
2011
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48. On the possibility of braneworld quintessential inflation

Author

Mafalda Dias, MAFALDA DIAS, and Andrew Liddle

Subjects
Physics, Inflation, M-theory, Nuclear and High Energy Physics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), media_common.quotation_subject, FOS: Physical sciences, Context (language use), Inflaton, Cosmology, Theoretical physics, Classical mechanics, Brane cosmology, Restrictiveness, media_common, Quintessence, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We examine the possibility of achieving quintessential inflation, where the same field serves as both inflaton and quintessence, in the context of a five-dimensional braneworld. Braneworld cosmology provides an appropriate environment as it permits inflation with much steeper potentials than the conventional scenario, which is favourable to a late-time quintessence. We explore a wide space of models, together with contemporary observational data, to determine in which contexts such a picture is possible. We find that such a scenario, although attractive, is in fact impossible to achieve for the potentials studied due to the restrictiveness of current data., Comment: 11 pages RevTex file with 13 figures

Published
2010
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49. Numerical evaluation of the bispectrum in multiple field inflation—the transport approach with code

Author

Jonathan Frazer, David Seery, David J. Mulryne, and Mafalda Dias

Subjects
Vacuum state, interference, Astrophysics::Cosmology and Extragalactic Astrophysics, power spectrum, field theory, programming, 01 natural sciences, horizon, vacuum state, Gravitation, DESI, 0103 physical sciences, Cosmological perturbation theory, tree approximation, ddc:530, correlation function, Statistical physics, Boundary value problem, Quantum field theory, numerical calculations, 010306 general physics, Physics, 010308 nuclear & particles physics, scale dependence [bispectrum], Spectral density, Astronomy and Astrophysics, multiple field [inflation], boundary condition, Amplitude, gravitation, correlation, galaxy, Bispectrum
Abstract

We present a complete framework for numerical calculation of the power spectrum and bispectrum in canonical inflation with an arbitrary number of light or heavy fields. Our method includes all relevant effects at tree-level in the loop expansion, including (i) interference between growing and decaying modes near horizon exit; (ii) correlation and coupling between species near horizon exit and on superhorizon scales; (iii) contributions from mass terms; and (iv) all contributions from coupling to gravity. We track the evolution of each correlation function from the vacuum state through horizon exit and the superhorizon regime, with no need to match quantum and classical parts of the calculation; when integrated, our approach corresponds exactly with the tree-level Schwinger or `in-in' formulation of quantum field theory. In this paper we give the equations necessary to evolve all two- and three-point correlation functions together with suitable initial conditions. The final formalism is suitable to compute the amplitude, shape, and scale dependence of the bispectrum in models with $|f_{NL}|$ of order unity or less, which are a target for future galaxy surveys such as Euclid, DESI and LSST. As an illustration we apply our framework to a number of examples, obtaining quantitatively accurate predictions for their bispectra for the first time. Two accompanying reports describe publicly-available software packages that implement the method.

Published
2016

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