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1. Strategy for an early simultaneous introduction of four-pillars of heart failure therapy: results from a single center experience

Author

Severino, Paolo, D’Amato, Andrea, Prosperi, Silvia, Mariani, Marco Valerio, Myftari, Vincenzo, Labbro Francia, Aurora, Cestiè, Claudia, Tomarelli, Elisa, Manzi, Giovanna, Birtolo, Lucia Ilaria, Marek-Iannucci, Stefanie, Maestrini, Viviana, Mancone, Massimo, Badagliacca, Roberto, Fedele, Francesco, and Vizza, Carmine Dario

Published
2024
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6. Long-Term Evaluation of Lipid Profile Changes in Olympic Athletes.

Author

Di Gioia, Giuseppe, Buzzelli, Lorenzo, Maestrini, Viviana, Squeo, Maria Rosaria, Lemme, Erika, Monosilio, Sara, Serdoz, Andrea, Fiore, Roberto, Zampaglione, Domenico, Segreti, Andrea, and Pelliccia, Antonio

Subjects
HDL cholesterol, RISK assessment, HYPERLIPIDEMIA, LIPIDS, ENDURANCE sports, SEX distribution, LDL cholesterol, DESCRIPTIVE statistics, AGE distribution, ATHLETES, LONGITUDINAL method, SPORTS events, TRIGLYCERIDES, CORONARY artery disease, DISEASE risk factors, DISEASE complications
Abstract

Dyslipidemia is a major contributor to the development of atherosclerotic cardiovascular disease. Despite high level of physical activity, athletes are not immune from dyslipidemia, but longitudinal data on the variation of lipids are currently lacking. We sought to assess lipid profile changes over time in Olympic athletes practicing different sports disciplines (power, skills, endurance, and mixed). We enrolled 957 consecutive athletes evaluated from London 2012 to Beijing 2022 Olympic Games. Dyslipidemia was defined as low-density lipoprotein (LDL) ≥115 mg/dl, high-density lipoprotein (HDL) <40 mg/dl for males, or HDL <50 mg/dl for females. Hypertriglyceridemia was defined as triglycerides >150 mg/dl. At the follow-up, a variation of ±40 mg/dl for LDL, ±6 mg/dl for HDL, and ±50 mg/dl for triglycerides was considered relevant. Athletes with follow-up <10 months or taking lower lipid agents were excluded. Follow-up was completed in 717 athletes (74.9%), with a mean duration of 55.6 months. Mean age was 27.2 ± 4.8 years old, 54.6% were male (n = 392). Overall, 19.8% (n = 142) athletes were dyslipidemic at both blood tests, being older, practicing nonendurance sports, and predominantly male. In 69.3% (n = 129) of those with elevated LDL at t0, altered values were confirmed at follow-up, while the same occurred in 36.5% (n = 15) with hypo-HDL and 5.3% (n = 1) in those with elevated triglycerides. Weight and fat mass percentage modifications did not affect lipid profile variation. LDL hypercholesterolemia tends to persist over time especially among male, older, and nonendurance athletes. LDL hypercholesterolemia detection in athletes should prompt early preventive intervention to reduce the risk of future development of atherosclerotic disease. [ABSTRACT FROM AUTHOR]

Published
2024
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7. The impact of vaccination status on post-acute sequelae in hospitalized COVID-19 survivors using a multi-disciplinary approach: An observational single center study

Author

Gianluca, Agnes, Alida, Albante, Maria, Alfarano, Fabio, Araimo Morselli, Daniela, Auricchio, Giovanna, Barletta, Federico, Bilotta, Matteo, Brisciani, Katia, Bruno, Clelia, Bucarelli Maria, Alessandro, Cappannoli, Giancarlo, Ceccarelli, Paola, Celli, Stella, Consolo, Giulia, Consoli, Claudia, Croce, Beatrice, Crocitti, Letizia, D'Antoni, Francesco, De Lazzaro, Daniela, De Lauri, Francesca, De Persis, Maria, De Rose, Andrea, Del Bianco, Valerio, Di Bella, Laura, Di Sano, Carmela, Di Santo, Domenico, Filomena, Lorena, Giannetti, Giovanni, Giordano, Stefano, Ianni, Carmela, Imperiale, Eugenia, Magnanimi, Chiara, Manganelli, Federica, Maldarelli, Giovanna, Manzi, Serena, Marcon, Valerio, Mariani Marco, Sabina, Martelli, Teresa, Messina, Matteo, Neccia, Martina, Novelli, Silvia, Papa, Fabiola, Pasqualitto, Elisa, Pattelli, Filippo, Pecorari, Serena, Perrella, Ilaria, Passarelli, Mario, Piazzolla, Agostino, Piro, Monica, Portieri, Fabiola, Ratini, Claudia, Ricci, Hilde, Romano, Anna, Sabani, Pietro, Santopietro, Alessandra, Tanzilli, Guglielmo, Tellan, Luca, Titi, Marco, Tocci, Paolo, Tordiglione, Antonella, Tosi, Fausto, Trigilia, Noemi, Verduci, Paola, Vaccaro, Birtolo, Lucia Ilaria, Di Pietro, Gianluca, Ciuffreda, Antonella, Improta, Riccardo, Monosilio, Sara, Prosperi, Silvia, Cimino, Sara, Galea, Nicola, Severino, Paolo, Galardo, Gioacchino, Colaiacomo, Maria Chiara, Pasculli, Patrizia, Petroianni, Angelo, Palange, Paolo, Mastroianni, Claudio Maria, de Vito, Laura, Catalano, Carlo, Pugliese, Francesco, Ciardi, Maria Rosa, Celli, Paola, Badagliacca, Roberto, Fedele, Francesco, Vizza, Carmine Dario, Maestrini, Viviana, and Mancone, Massimo

Published
2024
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9. Physical exercise in hypertensive heart disease: From the differential diagnosis to the complementary role of exercise

Author

Pastore, Maria Concetta, Cavigli, Luna, Olivoni, Gabriele, Morrone, Francesco, Amati, Francesca, Imbalzano, Egidio, Rinaldi, Andrea, Liga, Riccardo, Mattioli, Anna Vittoria, Scicchitano, Pietro, Curcio, Antonio, Barillà, Francesco, Ciccarelli, Michele, Maestrini, Viviana, Perrone Filardi, Pasquale, D'Ascenzi, Flavio, and Cameli, Matteo

Published
2024
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22. Precision measurement of cardiac structure and function in cardiovascular magnetic resonance using machine learning

Author

Davies, Rhodri H., Augusto, João B., Bhuva, Anish, Xue, Hui, Treibel, Thomas A., Ye, Yang, Hughes, Rebecca K., Bai, Wenjia, Lau, Clement, Shiwani, Hunain, Fontana, Marianna, Kozor, Rebecca, Herrey, Anna, Lopes, Luis R., Maestrini, Viviana, Rosmini, Stefania, Petersen, Steffen E., Kellman, Peter, Rueckert, Daniel, Greenwood, John P., Captur, Gabriella, Manisty, Charlotte, Schelbert, Erik, and Moon, James C.

Published
2022
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23. Sodium-Glucose Cotransporter 2 Inhibitor Therapy in Different Scenarios of Heart Failure: An Overview of the Current Literature.

Author

Prosperi, Silvia, D'Amato, Andrea, Labbro Francia, Aurora, Monosilio, Sara, Cestiè, Claudia, Marek Iannucci, Stefanie, Netti, Lucrezia, Angotti, Danilo, Filomena, Domenico, Mariani, Marco Valerio, Myftari, Vincenzo, Germanò, Rosanna, Cimino, Sara, Mancone, Massimo, Badagliacca, Roberto, Maestrini, Viviana, Severino, Paolo, and Vizza, Carmine Dario

Subjects
HEART valve diseases, SODIUM-glucose cotransporter 2 inhibitors, CORONARY disease, HEART failure, HEART diseases
Abstract

Heart failure (HF) is a complex syndrome that requires tailored and patient-centered treatment. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) constitute one of the four pillars of the medical treatment of HF. However, the 2023 ESC guidelines treat HF as a single entity without making clear distinctions in phenotypes according to etiology. This creates a "gap in knowledge", causing much debate about the applicability of these drugs in peculiar clinical settings that are etiological and/or predisposing clinical conditions for HF. Furthermore, considering the variety of etiologies and different pathophysiological backgrounds of HF, one might question whether the use of SGLT2is is equally beneficial in all types of HF and whether certain drug-related properties may be exploited in different contexts. For example, SGLT2is can improve the metabolic and inflammatory state, which is fundamental in ischemic heart disease. Anti-inflammatory power can also play a paramount role in myocarditis or cardiotoxicity, while improving the congestive state and reducing filling pressure may be even more fundamental in restrictive heart disease or advanced heart disease. This review aims to gather the evidence currently present in the literature concerning the advantages or the disadvantages of using these drugs in these particular clinical settings, with the goal being an optimized and highly personalized treatment for HF. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Insight on Exercise-Induced Heart Remodeling in Different Track and Field Disciplines.

Author

Di Gioia, Giuseppe, Ferrera, Armando, Vespasiano, Francesca, Maestrini, Viviana, Monosilio, Sara, Lemme, Erika, Serdoz, Andrea, Mango, Federica, Casciani, Emanuele, Pelliccia, Antonio, and Squeo, Maria Rosaria

Subjects
RIGHT heart atrium, RUNNING races, LONG-distance runners, STRESS echocardiography, TRACK & field, MALE athletes
Abstract

Background: The foot racing disciplines include sprints, middle distances, and long distances, which vary in terms of intensities, duration of training, and metabolic demands. The aim of our study was to evaluate the differences in morpho-functional parameters describing cardiac remodeling in a large cohort of Olympic athletes practicing the different track subspecialties. Methods: We evaluated 140 track and field (52.1% males, mean age 26.3 ± 4.3 years) Olympic athletes divided into four groups according to the distance performed: Group A (46, 32.9%): 100 and 200 mt; Group B (34, 24.3%): 400 mt; Group C (25, 17.9%): 800, 1500, and 3000 mt; Group D (35, 24.9%): 5000, 10,000 mt, and marathon distance. The athletes underwent a pre-participation screening, which included transthoracic echocardiography and exercise stress testing. Results: In Group A and in Group B, most athletes presented normal cardiac geometry (41/46, 89.1% in Group A and 31/34, 91.2% in Group B, p < 0.0001). Instead, in Groups C and D, more than half presented eccentric cardiac remodeling (13\25, 52% in Group C and 23\35, 65.7% in Group D). No significant differences were found between subspecialties in LVEF (p = 0.587), diastolic function (p = 0.431), and training hours/week (p = 0.078). Conclusions: In conclusion, the presence and extent of cardiac remodeling vary according to the distance of the discipline practiced, with the largest dimensional increase in both left and right ventricles and atria in mid- and long-distance runners and the lowest in sprinters. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Italian Cardiological Guidelines (COCIS) for Competitive Sport Eligibility in athletes with heart disease: update 2024.

Author

ZEPPILLI, Paolo, Biffi, Alessandro, Cammarano, Michela, Castelletti, Silvia, Cavarretta, Elena, Cecchi, Franco, Colivicchi, Furio, Contursi, Maurizio, Corrado, Domenico, D'andrea, Antonello, Deferrari, Francesco, Delise, Pietro, Russo, Antonio Dello, Gabrielli, Domenico, Giada, Franco, Indolfi, Ciro, Maestrini, Viviana, Mascia, Giuseppe, MOS, Lucio, and Oliva, Fabrizio

Published
2024
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27. Abstract 14664: Heart Failure as the Cancer for the Heart: The Prognostic Role of the New HLM Score

Author

Severino, Paolo, DʼAmato, Andrea, Mariani, Marco Valerio, Prosperi, Silvia, Alunni Fegatelli, Danilo, Birtolo, Lucia Ilaria, Costi, Bettina, Angotti, Danilo, Cerrato, Enrico, Lavalle, Carlo, Maestrini, Viviana, Pizzi, Carmine, Foà, Alberto, vestri, annarita, Palazzuoli, Alberto, Mather, Paul J., Casale, Paul N., Mancone, Massimo, and Fedele, Francesco

Published
2022
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28. Appropriate use criteria for cardiovascular magnetic resonance imaging (CMR): SIC—SIRM position paper part 1 (ischemic and congenital heart diseases, cardio-oncology, cardiac masses and heart transplant)

Author

Pontone, Gianluca, Di Cesare, Ernesto, Castelletti, Silvia, De Cobelli, Francesco, De Lazzari, Manuel, Esposito, Antonio, Focardi, Marta, Di Renzi, Paolo, Indolfi, Ciro, Lanzillo, Chiara, Lovato, Luigi, Maestrini, Viviana, Mercuro, Giuseppe, Natale, Luigi, Mantini, Cesare, Polizzi, Aldo, Rabbat, Mark, Secchi, Francesco, Secinaro, Aurelio, Aquaro, Giovanni Donato, Barison, Andrea, and Francone, Marco

Published
2021
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29. Myocardial contractility recovery following acute pressure unloading after transcatheter aortic valve intervention (TAVI) in patients with severe aortic stenosis and different left ventricular geometry: a multilayer longitudinal strain echocardiographicanalysis

Author

Cimino, Sara, Monosilio, Sara, Luongo, Federico, Neccia, Matteo, Birtolo, Lucia Ilaria, Salvi, Nicolò, Filomena, Domenico, Mancone, Massimo, Fedele, Francesco, Agati, Luciano, and Maestrini, Viviana

Published
2021
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30. Association between FT3 Levels and Exercise-Induced Cardiac Remodeling in Elite Athletes.

Author

Di Gioia, Giuseppe, Squeo, Maria Rosaria, Lemme, Erika, Maestrini, Viviana, Monosilio, Sara, Ferrera, Armando, Buzzelli, Lorenzo, Valente, Daniele, and Pelliccia, Antonio

Subjects
VENTRICULAR septum, OLYMPIC athletes, THYROTROPIN, THYROID hormones, ELITE athletes, ENDURANCE athletes
Abstract

Background: Previous studies demonstrated that variations of fT3, even within the euthyroid range, can influence cardiac function. Our aim was to investigate whether thyroid hormones, even within the euthyroid range, are associated with the magnitude of exercise-induced cardiac remodeling in Olympic athletes. Methods: We evaluated 1342 Olympic athletes (mean age 25.6 ± 5.1) practicing different sporting disciplines (power, skills, endurance, and mixed). Athletes underwent blood testing (thyroid stimulating hormone, fT3, and fT4), echocardiography, and exercise-stress testing. Athletes taking thyroid hormones, affected by thyroiditis, or presenting TSH out of ranges were excluded. Results: The level of thyroid hormones varied according to the type of sporting discipline practiced: endurance athletes presented the lowest TSH (p < 0.0001), fT3 (p = 0.007), and fT4 (p < 0.0001) in comparison to the remaining ones. Resting heart rate (HR) was positively correlated to fT3 in athletes of different disciplines (power: p = 0.0002, R2 = 0.04; skill: p = 0.0009, R2 = 0.05; endurance: p = 0.007, R2 = 0.03; and mixed: p = 0.04, R2 = 0.01). The same results were seen for peak HR in the exercise-stress test in athletes engaged in power, skill, and endurance (respectively, p < 0.0001, R2 = 0.04; p = 0.01, R2 = 0.04; and p = 0.005, R2 = 0.02). Moreover, a positive correlation was observed with cardiac dimensions, i.e., interventricular septum (power: p < 0.0001, R2 = 0.11; skill: p = 0.02, R2 = 0.03; endurance: p = 0.002, R2 = 0.03; mixed: p < 0.0001, R2 = 0.04). Furthermore, fT3 was directly correlated with the left ventricle (LV) end-diastolic volume in skills (p = 0.04, R2 = 0.03), endurance (p = 0.04, R2 = 0.01), and mixed (p = 0.04, R2 = 0.01). Conclusions: Thyroid hormones, even within the euthyroid range, are associated with cardiac adaptive response to exercise and may contribute to exercise-induced cardiac remodeling. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Prevalence of Hyperuricemia and Associated Cardiovascular Risk Factors in Elite Athletes Practicing Different Sporting Disciplines: A Cross-Sectional Study

Author

Di Gioia, Giuseppe, primary, Crispino, Simone Pasquale, additional, Maestrini, Viviana, additional, Monosilio, Sara, additional, Squeo, Maria Rosaria, additional, Lemme, Erika, additional, Segreti, Andrea, additional, Serdoz, Andrea, additional, Fiore, Roberto, additional, Zampaglione, Domenico, additional, and Pelliccia, Antonio, additional

Published
2024
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33. CMR Mapping: The 4th-Era Revolution in Cardiac Imaging

Author

Carrabba, Nazario, primary, Amico, Mattia Alexis, additional, Guaricci, Andrea Igoren, additional, Carella, Maria Cristina, additional, Maestrini, Viviana, additional, Monosilio, Sara, additional, Pedrotti, Patrizia, additional, Ricci, Fabrizio, additional, Monti, Lorenzo, additional, Figliozzi, Stefano, additional, Torlasco, Camilla, additional, Barison, Andrea, additional, Baggiano, Andrea, additional, Scatteia, Alessandra, additional, Pontone, Gianluca, additional, and Dellegrottaglie, Santo, additional

Published
2024
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34. Cluster Analysis of CMR Parameters in a Group of Olympic Athletes: Is It Time for a Tailored Morpho-functional Evaluation of Cardiac Remodeling?

Author

Monosilio, Sara, primary, Prosperi, Silvia, additional, Spinelli, Alessandro, additional, Lemme, Erika, additional, Gioia, Giuseppe Di, additional, Mango, Ruggiero, additional, Tonti, Giovanni, additional, Pedrizzetti, Gianni, additional, Gualdi, Gianfranco, additional, Squeo, Maria Rosaria, additional, Pelliccia, Antonio, additional, and Maestrini, Viviana, additional

Published
2024
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35. Electrical and structural remodelling in female athlete's heart: A comparative study in women vs men athletes and controls

Author

D'Ascenzi, Flavio, primary, Cavigli, Luna, additional, Marchese, Andrea, additional, Taddeucci, Simone, additional, Cappelli, Elena, additional, Roselli, Alessandra, additional, Bastone, Giuseppe, additional, Lemme, Erika, additional, Serdoz, Andrea, additional, Maestrini, Viviana, additional, Squeo, Maria Rosaria, additional, and Pelliccia, Antonio, additional

Published
2024
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36. CMR Mapping Techniques Evaluation in a Cohort of Olympic Athletes

Author

Prosperi, Silvia, primary, Monosilio, Sara, additional, Spinelli, Alessandro, additional, Lemme, Erika, additional, Gioia, Giuseppe Di, additional, Mango, Ruggiero, additional, Gualdi, Gianfranco, additional, Squeo, Maria Rosaria, additional, Pelliccia, Antonio, additional, and Maestrini, Viviana, additional

Published
2024
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37. Excessive Left Ventricular Trabeculation in Olympic Athletes: Is It a Matter of Ventricular Function?

Author

Monosilio, Sara, primary, Spinelli, Alessandro, additional, Prosperi, Silvia, additional, Lemme, Erika, additional, Mango, Ruggiero, additional, Gioia, Giuseppe Di, additional, Tonti, Giovanni, additional, Pedrizzetti, Gianni, additional, Gualdi, Gianfranco, additional, Squeo, Maria Rosaria, additional, Pelliccia, Antonio, additional, and Maestrini, Viviana, additional

Published
2024
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38. Arrhythmic Mitral Valve Prolapse Phenotype: An Unsupervised Machine-learning Analysis Using a Multi-center Registry

Author

Figliozzi, Stefano, primary, Akyea, Ralph Kwame, additional, Lopes, Pedro M, additional, Moura-Ferreira, Sara, additional, Tondi, Lara, additional, Mushtaq, Saima, additional, Censi, Stefano, additional, Pavon, Anna Giulia, additional, Bassi, Ilaria, additional, Galian, Laura, additional, Teske, Arco J, additional, Filomena, Domenico, additional, Torlasco, Camilla, additional, Monney, Pierre, additional, Maestrini, Viviana, additional, Pedrotti, Patrizia, additional, Vandenberk, Bert, additional, Squeri, Angelo, additional, Lombardi, Massimo, additional, Schwitter, Juerg, additional, Aquaro, Giovanni Donato, additional, Chiribiri, Amedeo, additional, Palomares, José F Rodríguez, additional, Monti, Lorenzo, additional, Yilmaz, Ali, additional, Andreini, Daniele, additional, Florian, Anca, additional, Francone, Marco, additional, Pontone, Gianluca, additional, Abecassis, Joao, additional, Leiner, Tim, additional, Badano, Luigi P, additional, Bogaert, Jan, additional, Georgiopoulos, Georgios, additional, and Masci, Pier Giorgio, additional

Published
2024
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43. ECG evaluation in 11 949 Italian teenagers: results of screening in secondary school

Author

Mancone, Massimo, Maestrini, Viviana, Fusto, Antonio, Adamo, Francesco, Scarparo, Paola, D’Ambrosi, Alessandra, Cinque, Alessandra, Gatto, Maria Chiara, Salvi, Nicolò, Agnes, Gianluca, Pucci, Mariateresa, Birtolo, Lucia Ilaria, Marruncheddu, Laura, Genuini, Igino, De Lazzari, Claudio, Severino, Paolo, Giunta, Giuseppe, Lavalle, Carlo, Fegatelli, Danilo Alunni, Vestri, Annarita, and Fedele, Francesco

Published
2022
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45. Heart failure ‘the cancer of the heart’: the prognostic role of the HLM score

Author

Severino, Paolo, primary, Mancone, Massimo, additional, D'Amato, Andrea, additional, Mariani, Marco Valerio, additional, Prosperi, Silvia, additional, Alunni Fegatelli, Danilo, additional, Birtolo, Lucia Ilaria, additional, Angotti, Danilo, additional, Milanese, Alberto, additional, Cerrato, Enrico, additional, Maestrini, Viviana, additional, Pizzi, Carmine, additional, Foà, Alberto, additional, Vestri, Annarita, additional, Palazzuoli, Alberto, additional, Vizza, Carmine Dario, additional, Casale, Paul N., additional, Mather, Paul J., additional, and Fedele, Francesco, additional

Published
2023
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46. Periodic health evaluation in athletes competing in Tokyo 2020: from SARS-CoV-2 to Olympic medals

Author

Squeo, Maria Rosaria, primary, Monosilio, Sara, additional, Gismondi, Alessandro, additional, Perrone, Marco, additional, Gregorace, Emanuele, additional, Lemme, Erika, additional, Di Gioia, Giuseppe, additional, Mango, Ruggiero, additional, Prosperi, Silvia, additional, Spataro, Antonio, additional, Maestrini, Viviana, additional, Di Giacinto, Barbara, additional, and Pelliccia, Antonio, additional

Published
2023
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48. Sizing SGLT2 Inhibitors Up: From a Molecular to a Morpho-Functional Point of View

Author

Prosperi, Silvia, primary, D’Amato, Andrea, additional, Severino, Paolo, additional, Myftari, Vincenzo, additional, Monosilio, Sara, additional, Marchiori, Ludovica, additional, Zagordi, Lucrezia Maria, additional, Filomena, Domenico, additional, Di Pietro, Gianluca, additional, Birtolo, Lucia Ilaria, additional, Badagliacca, Roberto, additional, Mancone, Massimo, additional, Maestrini, Viviana, additional, and Vizza, Carmine Dario, additional

Published
2023
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49. Myocardial Edema and Prognosis in Amyloidosis

Author

Kotecha, Tushar, Martinez-Naharro, Ana, Treibel, Thomas A., Francis, Rohin, Nordin, Sabrina, Abdel-Gadir, Amna, Knight, Daniel S., Zumbo, Giulia, Rosmini, Stefania, Maestrini, Viviana, Bulluck, Heerajnarain, Rakhit, Roby D., Wechalekar, Ashutosh D., Gilbertson, Janet, Sheppard, Mary N., Kellman, Peter, Gillmore, Julian D., Moon, James C., Hawkins, Philip N., and Fontana, Marianna

Published
2018
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