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Background The blunting effect of maternal pertussis immunization during pregnancy on infant antibody responses induced by whole cell pertussis (wP) vaccination is not well-defined. Methods This randomized controlled trial (NCT02408926) followed term infants born to mothers vaccinated with tetanus-diphtheria-acellular pertussis (Tdap)-vaccine during pregnancy in Thailand. Infants received either acellular pertussis (aP)- or wP-containing vaccine at 2, 4, 6 and 18 months of age. A comparison group comprised wP-vaccinated children born to mothers not vaccinated during pregnancy. Antibodies against pertussis toxin (PT), filamentous haemagglutinin (FHA) and pertactin (PRN) were evaluated using commercial enzyme-linked immunosorbent assays (ELISA). Functionality of antibodies against B. pertussis was measured using B. pertussis growth inhibition assay (BGIA). Results After maternal Tdap vaccination, 158 infants vaccinated with aP-containing vaccines possessed higher antibody levels (p < 0.001) against all tested B. pertussis antigens post-priming compared to 157 infants receiving wP-containing vaccines. At one-month post-booster, only anti-FHA and anti-PRN antibodies were still significantly higher (p < 0.001) in the aP group. Significantly higher anti-PT and anti-FHA (p < 0.001), but not anti-PRN IgG, were observed among 69 wP-vaccinated infants born to control mothers compared to wP-vaccinated infants of Tdap-vaccinated mothers after primary and booster vaccination. The antibody functionality was higher in all wP vaccinated infants at all times. Conclusions Maternal Tdap vaccination inhibited more pertussis-specific responses in wP vaccinated infants compared to aP vaccinated infants, and the control group of unvaccinated women had highest pertussis-specific responses, persisting until after the booster dose. Antibody functionality was better in the wP groups. Thrasher Research Fund Award (EWAT 12348) Thailand Research Fund (TRF) (IRG5780015) NSTDA Center of Excellence in Clinical Virology (GCE 58-014-30-004) National Vaccine Institute Department of Pediatrics, Faculty of Medicine, Chulalongkorn University Region Auvergne-Rhone-Alpes Region Bourgogne-Franche-Comte Region Hauts-de-France Region Nouvelle-Aquitaine Institut National de la Sante et de la Recherche Medicale (Inserm) FWO (FWO 12R5719N) European Research Council under the European Union's Horizon 2020 research and innovation program (682540-TransMID) Ratchadaphiseksomphot Endowment Fund

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy is associated with a higher risk for severe morbidity and mortality when compared with infection in non-pregnant women of childbearing age. An increasing number of countries recommend immunization against SARS-CoV-2 in pregnant women. Recent studies provide preliminary and supportive evidence on safety, immunogenicity and effectiveness of coronavirus disease 2019 (COVID-19) vaccines in pregnant women; however, important knowledge gaps remain which warrant further studies. This collaborative consensus paper provides a review of the current literature on COVID-19 vaccines in pregnant women, identifies knowledge gaps and outlines priorities for future research to optimize protection against SARS-CoV-2 in the pregnant women and their infants. Copyright © 2021 Abu-Raya, Madhi, Omer, Amirthalingam, Giles, Flanagan, Zimmermann, O’Ryan, Safadi, Papaevangelou, Maertens, Wanlapakorn, Diaz-Brito, Tommelein and Esposito.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy is associated with a higher risk for severe morbidity and mortality when compared with infection in non-pregnant women of childbearing age. An increasing number of countries recommend immunization against SARS-CoV-2 in pregnant women. Recent studies provide preliminary and supportive evidence on safety, immunogenicity and effectiveness of coronavirus disease 2019 (COVID-19) vaccines in pregnant women; however, important knowledge gaps remain which warrant further studies. This collaborative consensus paper provides a review of the current literature on COVID-19 vaccines in pregnant women, identifies knowledge gaps and outlines priorities for future research to optimize protection against SARS-CoV-2 in the pregnant women and their infants.

Einleitung: Micro-needling ist eine minimal-invasive Technik, die nur wenig Nachsorge erfordert und häufig zur Hauterneuerung eingesetzt wird. Seine Wirksamkeit zur Verbesserung der Narben bleibt jedoch unklar. Das Hauptziel dieser Studie ist es zu untersuchen, ob Micro-needling die Hautdicke und[zum vollständigen Text gelangen Sie über die oben angegebene URL], 38. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2020)

Immunization during pregnancy has been recommended in an increasing number of countries. The aim of this strategy is to protect pregnant women and infants from severe infectious disease, morbidity and mortality and is currently limited to tetanus, inactivated influenza, and pertussis-containing vaccines. There have been recent advancements in the development of vaccines designed primarily for use in pregnant women (respiratory syncytial virus and group B Streptococcus vaccines). Although there is increasing evidence to support vaccination in pregnancy, important gaps in knowledge still exist and need to be addressed by future studies. This collaborative consensus paper provides a review of the current literature on immunization during pregnancy and highlights the gaps in knowledge and a consensus of priorities for future research initiatives, in order to optimize protection for both the mother and the infant. © Copyright © 2020 Abu-Raya, Maertens, Edwards, Omer, Englund, Flanagan, Snape, Amirthalingam, Leuridan, Damme, Papaevangelou, Launay, Dagan, Campins, Cavaliere, Frusca, Guidi, O'Ryan, Heininger, Tan, Alsuwaidi, Safadi, Vilca, Wanlapakorn, Madhi, Giles, Prymula, Ladhani, Martinón-Torres, Tan, Michelin, Scambia, Principi and Esposito.

Einleitung: PROMs (Patient reported outcome measurement) sind ein wichtiger Bestandteil in der klinischen Praxis und in der Forschung. Die Entwicklung (elektronischer) Gesundheitstechnologien ermöglichen noch nie dagewesene Möglichkeiten zur systematischen Erfassung von Informationen via PROMs.[zum vollständigen Text gelangen Sie über die oben angegebene URL], 37. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2019)

Einleitung: Silikon Gel Sheets (SGS) werden häufig bei der Nachbehandlung von Verbrennungen eingesetzt, manchmal kombiniert mit Druckkleidung, um die Wirksamkeit bei der Behandlung von hypertrophen Narben zu erhöhen. Daher wurde vor kurzem eine kohäsive Silikonbinde entwickelt, die Kompression[zum vollständigen Text gelangen Sie über die oben angegebene URL], 37. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2019)

Einleitung: Die Bildung einer hypertrophen Narbe ist eine bekannte Komplikation nach Verbrennungen. Dies führt zu massiven Einschränkungen im täglichen Leben. Es ist allgemein bekannt, dass die Hypertrophie und die Narbenkontraktur vermindert werden kann durch eine Reduktion der Spannung[zum vollständigen Text gelangen Sie über die oben angegebene URL], 35. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2017)

Scar Academy ist ein internationales Ausbildungsprogramm für Fachkräfte aus dem Gesundheitswesen, welches sich dem Verständnis und der Behandlung von (Verbrennungs)Narben widmet. Scar Academy wurde 2010 durch Oscare entwickelt, mit dem Ziel das Wissen um Techniken und Resultate im Narbenmanagement[zum vollständigen Text gelangen Sie über die oben angegebene URL], 35. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2017)

Elk jaar lopen 100 miljoen patiënten littekens op door een chirurgische ingreep, chirurgie na trauma en brandwonden (1). Hypertrofische littekens zijn verheven littekens die boven het normale huidoppervlakte liggen (2) en worden getypeerd door een rode kleur, verminderde soepelheid, pijn en jeuk. Ze hebben vaak esthetische gevolgen (veranderd uiterlijk) maar veroorzaken ook fysieke en sociale beperkingen.

Objective Quality of life (QOL) is one of the leading outcomes in burn care research. This study classifies subscales of common QOL measures within the International Classification of Functioning disability and health (ICF) framework to determine to which extent the measures are complementary or overlapping and to investigate whether the instruments are able to describe the full spectrum of patients’ functioning. Methods A literature search was performed to determine the most frequently used questionnaires in burn research. The subscales of the three mostly used questionnaires were classified within the ICF framework. Results Two generic measures, the Short Form-36 items (SF-36) and the European Quality of Life 5 Dimensions (EQ-5D), and a disease specific measure, the Burn Specific Health Scale-Brief (BSHS-B), were analyzed. The BSHS-B covered most domains and was the only scale that included personal factors. The SF-36 included only one domain in the activity limitations and similar to the EQ-5D no contextual factors were included. Environmental factors were not addressed in the questionnaires, even though these may have an impact on the quality of life in patients with burns. Conclusion To capture the full spectrum of dysfunctioning a combination of the BSHS-B with a generic questionnaire seems obligatory. However still some domains of functioning remain uncovered.

Neuritis vestibularis is een vaak voorkomende oorzaak van vertigo. Bij deze aandoening heeft de vertigo typisch een acuut tot subacuut begin, verergert deze door hoofdbewegingen en positionele veranderingen en kan die gepaard gaan met autonome symptomen , evenwichtsstoornissen, valneiging en een spontane horizontale nystagmus. Een centrale pathologie en andere perifere oorzaken moeten, zeker bij een atypische presentatie van de klachten, opgenomen worden in de differentiaaldiagnose. De diagnose wordt gesteld op basis van de anamnese, een klinisch onderzoek en een uitgebreid vestibulair en auditief onderzoek. Neuritis vestibularis wordt initieel symptomatisch behandeld. Na de acute fase is vestibulaire rehabilitatie aangewezen indien geen spontaan herstel optreedt van het aangedane vestibulaire stelsel.