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El reciente reporte técnico lanzado por Naciones Unidas en torno al cambio climático y sus consecuencias para el planeta fue demoledor. Pero, innegablemente, fue la revelación de aquello que no puede seguir siendo tapado con un dedo. El calentamiento global nos obliga urgentemente a pensar no sólo nuevos sistemas de desarrollo social, económico y cultural, sino además nuevos o renovados mecanismos legales que puedan responder efectivamente a la vorágine de los riesgos aparejados a tal desarrollo.

En un contexto nacional e internacional de emergencia sanitaria que generó una situación atípica de cierre simultáneo de todas las instituciones educativas, atravesamos una experiencia del ejercicio de la docencia extremadamente particular: una migración forzada hacia la virtualidad cargada de incertidumbre. En este escenario, se reactualiza la pregunta por las desigualdades y su presencia en las trayectorias educativas, en este caso, de estudiantes universitarias/os de la universidad pública. Aquí presentamos algunas reflexiones, preguntas y algunos pasos en el camino de la interpretación, para que, en toda la vorágine del teletrabajo en pandemia, lo que pasa a quienes están a ambos lados de la pantalla no nos pase desapercibido.

Taylor Swift has lived half her life at the centre of a music industry maelstrom: wildly successful, she built her career at a time when the record industry was just emerging from a decade-long str...

Cancer stem cells (CSCs) are responsible for tumorigenesis, therapeutic resistance, and metastasis in hepatocellular cancer (HCC). Cancer/testis antigen Maelstrom (MAEL) is implicated in the formation of CSC phenotypes, while the exact role and underlying mechanism remain unclear. Here, we found the upregulation of MAEL in HCC, with its expression negatively correlated with survival outcome. Functionally, MAEL promoted tumor cell aggressiveness, tumor stem-like potentials, and resistance to sorafenib in HCC cell lines. Transcriptional profiling indicated the dysregulation of stemness in MAEL knockout cells and identified PTGS2 as a critical downstream target transactivated by MAEL. The suppression effect of MAEL knockout in tumor aggressiveness was rescued in PTGS2 overexpression HCC cells. A molecular mechanism study revealed that the upregulation of PTGS2 by MAEL subsequently resulted in IL-8 secretion and the activation of AKT/NF-κB/STAT3 signaling. Collectively, our work identifies MAEL as an important stemness regulation gene in HCC. Targeting MAEL or its downstream molecules may provide a novel possibility for the elimination of CSC to enhance therapeutic efficacy for HCC patients in the future.

Povzetek V članku so obravnavane značilnosti družinskega življenja v kontekstu poznomodernih družbenih sprememb in predstavljeni različni izzivi, s katerimi se družine srečujejo v vsakdanjem življenju (delitev družinskega dela, usklajevanje družine in dela idr.). Predstavljena so vprašanja s posebnim poudarkom na slovenskem kontekstu in posebnostih, kot so dobro razvite sorodstvene podporne mreže, tradicija zaposlitve žensk za polni delovni čas ipd. Avtorica obravnava nekatere značilnosti vojaških družin in izpostavlja, da bi morale raziskave o vojaških družinah upoštevati poseben odnos med vojaško organizacijo in družino ter tudi družbene okoliščine, ki so v zadnjih desetletjih bistveno spremenile družinsko življenje, ter predlaga vpeljavo koncepta družinske prakse. Ključne besede Družine, pozna modernost, starševanje, vojaške družine, Slovenija. Abstract This article deals with the characteristics of family life in the context of late-modern social changes, and presents various challenges that families are consequently facing in everyday life (among others, the division of family labour and the reconciliation of family and work). The author addresses these issues with a special emphasis on Slovenia, taking into account the specificities of the country. The main characteristics of military families are also presented. The author argues that research into military families should take into account the specific relationship between the military organization and the family, as well as the social circumstances that have shaped family life significantly in recent decades. Key words Families, late modernity, parenting, military families, Slovenia.

This commentary has been written during the maelstrom of COVID-19 response, at a time when both Norway and Australia are ‘flattening the curve’ by implementing strong social distancing measures, wi...

In ‘Freighted Love: Teaching, Learning, and Making a Home in the Maelstrom’ Christina Heatherton describes the connections between poetry, theories of urban space, and what geographer Clyde Woods c...

Slides of presentation of first results of MAELSTROM Application Benchmarks, as presented at ISC22.

I held an HPC introduction lecture at the MAELSTROM Boot Camp.

The Lofoten Maelstrom has been known for centuries as one of the strongest open-ocean tidal currents in the world, estimated to reach 3 m s−1, and by some estimates as much as 5 m s−1. The strong current gives rise to choppy seas when waves enter the Moskenes Sound, making the area extremely difficult to navigate. Despite its reputation, few studies of its strength exist and no stationary in situ measurements for longer time periods have been made due to the challenging conditions. By deploying for the first time in situ wave and current instruments, we confirm some previous estimates of the strength of the current. We also show that its strength is strongly connected with wave breaking. From a consideration of specific forcing terms in the dynamical energy balance equation for waves on a variable current, we assess the impact of the underlying current using a convenient metric formulated as a function of the horizontal current gradients. We find that the horizontal gradients are a likely explanation for the observed enhanced wave breaking during strong currents at a rising tide.

With Web 5.0, the mobile phone has become the terminal device to get mobile information, and more and more social software has been popularized on the phone. Network short video app is one of the most prominent representatives. In the high demand of the market, short videos’ emergence constantly refreshes people’s horizon, increasing people’s desire to watch videos. For the audience, they not only watch the video but also have to meet social needs. It has led to the rapid expansion of the size of short video apps. Whether it is “Meipai” or “Kuaishou” released in China, or “TikTok” which focuses on 800 million users, or a series of short online video apps such as Instagram abroad, most of them take “second” as the length of the video, announced the short video “second-reading era” of the arrival. Through the video is created a carnival, and the audience has become a carnival maelstrom of followers. We need to analyze what kind of operation and management model shapes short video app development behind the audience. This article chose “TikTok” as a case study to analyze the “TikTok Operation Management Pattern.” The full text comprises 1. apps development, 2. The article has four parts: The first part elaborates the short video app’s development extremely characteristic. In the second part, the author expounds on the operation and management of TikTok. The third part focuses on the content operation and management of TikTok and its characteristics. The last part is about how to improve management operation.

Between receiving Higashide’s Better Buses, Better Cities and publishing this review, the world has been swept up in the maelstrom of covid-19. As a result of physical distancing and lockdown order...

It is not hard to argue that the terror attacks on September 11, 2001, and the subsequent horrific violent acts that have been carried out in the name of Islam in cities like, for example, Madrid, London, Paris, Brussels, Berlin, Nice or Stockholm have all had a serious impact on public perceptions of Islam and Muslims in the West. One way of understanding the outcome of these processes is to argue that they have contributed to and produced and strengthened what Riem Spielhaus and I call narratives of inclusion and exclusion (Larsson and Spielhaus 2013, 2017). In this article I will use narratives of inclusion and exclusion as a backdrop and heuristic tool for analysing and discussing the impacts of these two grand ideal-type narratives on museums planning to display so-called Islamic artefacts.

China's clampdown on plastic waste imports, the so-called yanglaji, or 'foreign rubbish' threw the global recycling industry into a maelstrom. The author looks at the impact the ban had and discovers how China is going to tackle its own plastic rubbish.

This paper explores spectatorial encounters with criminal trials. Particularly focusing on the 2018 work of Australian contemporary visual artist Julie Fragar that followed her watching murder trials in the Supreme Court of Queensland, it is argued that the artist as a legal outsider grapples with the inhumanity of the trial. This grappling can go in two directions. For some there is a need to bring the human back, to see the person beneath the mask of the role that they are performing, to connect the gothic horror of the trial back to a redeeming humanism. For others, and this is evident in Fragar, the horror of the inhumanity is visceral and overpowering, and the grotesque masque of judgment needs to be witnessed. Both perform a corrective and critique to the business as usual of processing, judging and stamping onto human lives that is legal insider’s performance in the criminal trial.

In 1887, amateur theatrical performer Cora Urquhart Brown Potter turned professional amid a maelstrom of international newspaper coverage. Newspapers picked up the story of her career, feeding a desire for salacious gossip at the expense of the elite celebrity cast as a fallen woman. Yet, Potter and the press developed a symbiotic relationship, as her non-traditional path to the stage required that she transform her personal celebrity into a professional one in order to attract audiences and bookings. The papers obliged and, as the story developed and her celebrity transformed, they shifted their coverage of Potter’s journey from society columns, to theatrical columns, to sensational front-page spreads. Potter’s early career paralleled and capitalised on such new developments in the newspaper industry and its messaging. While the press continued to sell her scandal, Potter used the papers to profit from her society past while forging her future as a theatre professional.

The inclusion 'ideal' is one which has been both celebrated and maligned. It paved the way for equality; but also, out of its diversity sprang many misconceptions and concerns for children with Special Educational Needs and Disabilities (SEND). It is within this maelstrom of difficulty that the Special Educational Needs Co‐ordinator (SENCo) role is placed, so that those undertaking the position of SENCo face numerous barriers in the pursuit of providing effectively for children with SEND. Semi‐structured interviews were conducted with fifteen SENCos employed at mainstream primary schools within the North West of England. Findings revealed conflict between how SENCos viewed their role and responsibilities, and the expectations that they perceived to be placed on them by parents of children with SEND and mainstream colleagues. This study brings to the fore the complexities of the role of the SENCo, and the continuing demands placed on these practitioners. [ABSTRACT FROM AUTHOR]

Cet article s’attache à montrer l’usage d’un texte littéraire comme outil en situation d’enquête ethnographique et artistique. Une descente dans le maelström d’Edgar Allan Poe - qui met en scène une image possible des abîmes (le maelström) -, devient le moyen de penser des dangers futurs difficilement perceptibles dans le présent en proposant un modèle dynamique qui fluctue entre mondes confinés et « devenir-abîme » des mondes. L’emboitement des techniques narratives et des techniques d’entretiens offre la possibilité de dégager des techniques de perceptions et d’alerte, de même que les attachements nécessaires face à des devenirs mouvants et potentiellement catastrophiques. This article aims to show the use of a literary short story as a tool in ethnographic and artistic investigation situations. A descent into Edgar Allan Poe’s maelström - which stages a possible image of the abyss (the maelstrom) – allows to address future dangers that are difficult to perceive in the present by proposing a dynamic model that fluctuates between confined worlds and the « becoming-abyss » of worlds. The interweaving of narrative and interviewing techniques offers the possibility of identifying techniques of perception and alert, as well as the necessary attachments in the face of changing and potentially catastrophic developments.

Resumen La crisis económica mundial que empezó en 2008 ha generado una caída del poder adquisitivo, reducción del consumo y contracción de la economía. Sin embargo, en medio de la crisis, se desarrolla una vorágine tecnológica que va a la par de un nuevo capitalismo mediante el incremento del uso de dispositivos digitales. El objetivo de este trabajo es analizar las nuevas claves de un capitalismo tecnológico generado por la democratización del consumo de bienes y servicios digitales y una arqueología tecnológica con periodos de obsolescencia cada vez más cortos. Es relevante la comprensión de este tipo de cambios, ya que permiten observar la relación entre el hombre y la tecnología y los usos que hacen de ella, con un enfoque en mejorar su calidad de vida y cerrar brechas como lo es la digital. Este trabajo usa una metodología del tipo documental de datos secundarios a nivel mundial sobre consumo tecnológico y su uso a tra vés de datos provenientes de ITU, Cepal, Eurostat y otros. Además, se realizó un análisis temporal del Smartphone desde el 2008 para establecer el crecimiento de su uso, teniendo en cuenta que ésta una de las tecnologías más utilizadas. Entre los hallazgos más notorios se evidencia que más del 75 % de la población a nivel mundial cuenta con un teléfono móvil, concluyen-do que esta tecnología facilita la gestión de la vida cotidiana en todos los aspectos: laboral, familiar, educativo, social, etc., es así que el Smartphone se convierte en una “navaja suiza” que facilita el diario vivir del ser humano. Abstract The global economic crisis that started in 2008 has generated a decrease in purchasing power, reduced consumption and a contraction in the economy. However, in the midst of the crisis, a technological maelstrom develops, which goes hand in hand with a new capitalism through the increase in the use of digital devices. The objective of this work is to analyze the new keys to a technological capitalism generated by the democratization of the consumption of digital goods and services and a technological archeology with increasingly shorter periods of obsolescence. The understanding of these types of changes is relevant since they allow us to observe the relationship between man and technology and its usesthe uses made of it, with a focus on improving their quality of life and closing gaps, such as the digital one. This work uses a documentary type methodology of secondary worldwide data on technological consumption and its use through data from ITU, Cepal, Eurostat and others. In addition, a temporal analysis of the Smartphone was carried out since 2008 to establish its growth, since it is one of the most widely used technologies. Among the most notorious findings, it is evidenced that more than 75 % of the world population has a mobile phone, concluding that this technology facilitates the management of daily life in all aspects: work, family, educational, social, etc. This is how the Smartphone becomes a “Swiss Army knife” that facilitates the daily life of human beings.

The novel coronavirus disease 2019 (COVID-19) pandemic has created a maelstrom of challenges affecting virtually every aspect of global healthcare system. Critical hospital capacity issues, depleted ventilator and personal protective equipment stockpiles, severely strained supply chains, profound economic slowdown, and the tremendous human cost all culminated in what is questionably one of the most profound challenges that humanity faced in decades, if not centuries. Effective global response to the current pandemic will require innovation and ingenuity. This chapter discusses various creative approaches and ideas that arose in response to COVID-19, as well as some of the most impactful future trends that emerged as a result. Among the many topics discussed herein are telemedicine, blockchain technology, artificial intelligence, stereolithography, and distance learning.

C’est dans l’œuvre de Poe, à laquelle Isidore Ducasse a plusieurs fois fait référence, qu’il put trouver la figure inspirante du maelstrom, ce tourbillon aquatique qui, par ses mouvements centrifuges et centripètes, devait inspirer la structure même des Chants de Maldoror. Ce n’est pas là néanmoins le seul emprunt de Ducasse à l’œuvre du novéliste américain qu’il aura vraisemblablement découvert à travers Baudelaire., It was in Poe’s work, which Isidore Ducasse makes reference to several times, that he found the inspiring figure of the maelstrom, that tornado in the water which, with its centrifugal and centripetal movements, was to inspire the very structure of the Chants de Maldoror. Nevertheless, this is not Ducasse’s only borrowing from the work of the American short-story writer, whom he probably discovered by way of Baudelaire.

Chromatin of male and female gametes undergoes a number of reprogramming events during the transition from germ cell to embryonic developmental programs. Although the rearrangement of DNA methylation patterns occurring in the zygote has been extensively characterized, little is known about the dynamics of DNA modifications during spermatid maturation. Here, we demonstrate that the dynamics of 5-carboxylcytosine (5caC) correlate with active transcription of LINE-1 retroelements during murine spermiogenesis. We show that the open reading frames of active and evolutionary young LINE-1s are 5caC-enriched in round spermatids and 5caC is eliminated from LINE-1s and spermiogenesis-specific genes during spermatid maturation, being simultaneously retained at promoters and introns of developmental genes. Our results reveal an association of 5caC with activity of LINE-1 retrotransposons suggesting a potential direct role for this DNA modification in fine regulation of their transcription., Blythe et al investigate the patterns of oxidized forms of the 5-methylcytosine DNA modification during spermatogenesis. They find that open reading frames of evolutionarily young and transcriptionally active LINE-1 retrotransposons are enriched in 5-carboxylcytosine (5caC) during spermatid maturation, suggesting a link between 5cac and LINE-1 activity.

The medieval crusades were complicated; their memory even more so. Their reuse across popular culture is a maelstrom of images, tropes, and ideas, further exacerbated when added to the mushrooming world of historical gaming. Not only is it impossible to imagine any kinds of games which have no inaccuracies, it is no longer possible to imagine any which would be deemed as accurate; we are no longer in the realm of historical accuracy but authenticity, and the extent to which a given imagined past coincides with our individual memory of that past. By exploring a range of tropes and historical icons established over time and which contribute to the mythical capital of popular memory, this chapter will explore the ways in which historical games construct authenticity through a range of crusading icons which resonate with popular ideas and tropes about the crusades.

The author recounts and interprets May’s reactions to the three most major issues in American life of the early 1970s—Vietnam, civil rights, and women’s rights. He publishes Power and Innocence, which reads the cultural upheaval in terms of powerlessness, and appears on the Dick Cavett Show seated between Hugh Hefner and feminist Susan Brownmiller.

This chapter discusses the concept of ”˜homeland” and the diagnostic category of ”˜homelessness” derived from it with which Heidegger describes the contemporary situation of man, the situation that is characterized essentially by the planetary rule of technology and the homelessness to which it has given rise. Heidegger claims to give thought to such homelessness and, at the same time, to recollect symbolic resources—such as the basic determination ”homeland”—that help man to keep his balance in the precarious situation of the present, in the “maelstrom of nihilism.” He does so in the framework of what he calls the thought of Being. Two figures appear in the horizon of Heideggerian thought and become determinative for his thematization of homeland and homelessness: Nietzsche and Holderlin. Heidegger responds to the “Pelagians” of the twentieth century, that is, those who believe that man is only a human problem and is in a position to save himself: “Only a god can save us.”.