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1. Comparison of outcome in 1809 patients treated with drug-eluting stents or bare-metal stents in a real-world setting

Author

Vogt A, Schoelmerich A, Pollner F, Schlitt M, Raaz U, Maegdefessel L, Reindl I, Buerke M, Werdan K, and Schlitt

Subjects
coronary stent, outcome, renal insufficiency, myocardial infarction, STEMI, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Alexander Vogt1, Anke Schoelmerich1, Franziska Pollner1, Manuela Schlitt1, Uwe Raaz1, Lars Maegdefessel2, Iris Reindl1, Michael Buerke1, Karl Werdan1, Axel Schlitt11Department of Medicine III, Martin Luther-University, Halle, Germany; 2Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USAPurpose: The aim of this study was to determine the long-term safety of drug-eluting stent (DES) versus bare metal stent (BMS) implantation in a “real-world” setting.Patients and methods: A total of 1809 patients who were treated with implantation of either BMS or DES were assessed. Kaplan-Meier and multivariate Cox regression analyses concerning primary endpoint of cardiac mortality were performed.Results: A total of 609 patients received DES. Mean age was 66.2 ± 11.3 years, 69.4% were male, and 1517 (83.8%) were treated for acute coronary syndrome (unstable angina 510 [28.2%], non-ST-elevation myocardial infarction [NSTEMI] 506 [28.0%], and ST-elevation myocardial infarction [STEMI] 501 [27.7%]). Mean follow-up was 34 ± 15 months. During follow-up, 268 patients died of cardiac causes (DES 42 [7.3%]; BMS 226 [19.6%]; P < 0.001). Univariate Kaplan-Meier analysis showed an advantage of DES over BMS concerning the primary endpoint (P < 0.001). When adjusting for classic risk factors and additional factors that affect the progression of coronary heart disease (CHD), DES was not found to be superior to BMS (hazard ratio 0.996, 95% confidence interval 0.455–2.182, P = 0.993). Severely impaired renal function was an independent predictor for cardiac mortality after stent implantation.Conclusion: Treatment with DES is safe in the long term, also in patients presenting with STEMI. However, in multivariate analyses it is not superior to BMS treatment.Keywords: coronary stent, outcome, renal insufficiency, myocardial infarction, STEMI

Published
2011

2. Nicht kodierende Ribonukleinsäure im kardiovaskulären System: Sonderforschungsbereich-Transregio (SFB-TRR 267)

Author

Engelhardt, S., Dimmeler, S., Heim, C., Bär, C., Böttger, T., Boon, R., Brandes, R. P., Braun, T., Dueck, A., Gagneur, J., Grote, P., Holdt, L. M., Jaé, N., Krishnan, J., Kupatt, C., Laugwitz, K.-L., Leisegang, M. S., Maegdefessel, L., Meitinger, T., Moretti, A., Müller-McNicoll, M., Sattler, M., Schnieke, A., Schulz, M., Schunkert, H., Schwalbe, H., Teupser, D., Thum, T., Weber, C., Wittig, I., and Zarnack, K.

Published
2022
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3. MiR-24 limits aortic vascular inflammation and murine abdominal aneurysm development

Author

Schrepfer, Sonja, Maegdefessel, L, Spin, JM, Raaz, U, Eken, SM, Toh, R, Azuma, J, Adam, M, Nagakami, F, Heymann, HM, and Chernugobova, E

Abstract

© 2014 Macmillan Publishers Limited.Identification and treatment of abdominal aortic aneurysm (AAA) remain among the most prominent challenges in vascular medicine. MicroRNAs (miRNAs) are crucial regulators of cardiovascular pathology and represent intrigu

Published
2014

4. Importance of smooth muscle p110alpha/AKT/FOXO1 signaling for the development of abdominal aortic aneurysm

Author

Vantler, M, primary, Schorscher, M, additional, Berghausen, E M, additional, Moore Iv, J B, additional, Wong, D, additional, Li, Z, additional, Gnatzy-Feik, L, additional, Zierden, M, additional, Mehrkens, D, additional, Adam, M, additional, Sengle, G, additional, Boor, P, additional, Maegdefessel, L, additional, Baldus, S, additional, and Rosenkranz, S, additional

Published
2023
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6. The circular RNA Ataxia-telangiectasia mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms

Author

Fasolo, F., primary, Winski, G., additional, Li, Z., additional, Wu, Z., additional, Winter, H., additional, Ritzer, J., additional, Glukha, N., additional, Roy, J., additional, Hultgren, R., additional, Pauli, J., additional, Busch, A., additional, Sachs, N., additional, Knappich, C., additional, Eckstein, H.H., additional, Boon, R.A., additional, Paloschi, V., additional, and Maegdefessel, L., additional

Published
2023
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7. Next Step Towards Precision Medicine in Thoracic Aortic Disease—The Potential of Long Noncoding RNAs.

Author

Buech, J., Pauli, J., Radner, C., Li, Z., Hagl, C., Pichlmaier, M., Maegdefessel, L., and Peterss, S.

Subjects
LINCRNA, PULMONOLOGY, INDIVIDUALIZED medicine, AORTA, ASCENDING aorta aneurysms
Abstract

This article discusses the potential of long noncoding RNAs (lncRNAs) in understanding thoracic aortic diseases. The researchers identified two lncRNAs, TMEM72-AS1 and LINC00632, that are expressed in vascular smooth muscle cells and differ between dilated and non-dilated areas of the aorta. The expression of these lncRNAs was significantly higher in dilated areas, particularly in tissues from patients with bicuspid aortic valve (BAV) and aortic regurgitation (AI). The findings suggest that these lncRNAs could be potential targets for diagnostic and therapeutic interventions in thoracic aortic diseases. [Extracted from the article]

Published
2024
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9. 27-jährige Schwangere mit Synkope und Dyspnoe nach Aortenklappenersatz vor 15 Jahren

Author

Maegdefessel, L., Issa, H., Scheler, C., Thäle, V., Schlitt, A., Hartelt, U., Grabitz, R., and Buerke, M.

Abstract

Zusammenfassung: Eine 27-jährige Patientin stellte sich in der 26. Schwangerschaftswoche mit Synkope, progredienter Belastungsdyspnoe und deutlicher Leistungseinschränkung in unserer Notaufnahme vor. Aufgrund einer kongenitalen valvulären Aortenstenose war 1993 ein alloplastischer Herzklappenersatz bei der Patientin durchgeführt worden. Nach entsprechender Diagnostik bestand der Verdacht auf eine Thrombose der Aortenklappenprothese mit begleitender kardialer Dekompensation. Bei zunehmender Kreislaufinstabilität erfolgte eine thrombolytische Therapie mit Tenecteplase. Eine nach Fibrinolyse durchgeführte Durchleuchtung stellte beide Klappenprothesenflügel frei beweglich und voll funktionsfähig dar. Die initiale Antikoagulation mit niedermolekularem Heparin wurde während des stationären Aufenthalts auf unfraktioniertes Heparin und später auf orale Antikoagulation umgestellt. Elektiv erfolgte die primäre Sectio in Intubationsnarkose in der 36. Schwangerschaftswoche. Mutter und Kind haben die Geburt komplikationslos überstanden. Die durch verschiedene Faktoren hervorgerufene Hyperkoaguabilität in der Schwangerschaft stellt speziell bei Patientinnen mit schon vorher bestehender Indikation zur therapeutischen Antikoagulation ein ernstzunehmendes Problem dar. Eine thrombolytische Therapie sollte Schwangeren als ultima ratio nicht vorenthalten werden.

Published
2024
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11. The circular RNA Ataxia-telangiectasia mutated (cATM) regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms

Author

Fasolo, F., primary, Winski, G., additional, Li, Z., additional, Wu, Z., additional, Winter, H., additional, Glukha, N., additional, Roy, J., additional, Hultgren, R., additional, Pauli, J., additional, Busch, A., additional, Sachs, N., additional, Knappich, C., additional, Eckstein, H.H., additional, Boon, R.A., additional, Paloschi, V., additional, and Maegdefessel, L., additional

Published
2022
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12. GPR55 deficiency in B-cells promotes atherosclerosis and regulates plasma cell maturation

Author

Guillamat-Prats, R, primary, Hering, D, additional, Rami, M, additional, Haerdtner, C, additional, Santovito, D, additional, Rinne, P, additional, Pagano, S, additional, Nicolas Vuilleumier, N, additional, Schmid, S, additional, Janjic, A, additional, Enard, W, additional, Weber, C, additional, Maegdefessel, L, additional, Hilgendorf, I, additional, and Steffens, S, additional

Published
2022
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13. B cell-specific GPR55 deficiency promotes atherosclerosis

Author

Guillamat-Prats, R., primary, Hering, D., additional, Rami, M., additional, Hädtner, C., additional, Santovito, D., additional, Rinne, P., additional, Bindila, L., additional, Hristov, M., additional, Pagano, S., additional, Vuilleumier, N., additional, Schmid, S., additional, Janjic, A., additional, Enard, W., additional, Weber, C., additional, Maegdefessel, L., additional, Faussner, A., additional, Hilgendorf, I., additional, and Steffens, S., additional

Published
2022
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18. Osteomodulin is a novel gene in cardiovascular calcification

Author

Skenteris, N.T., primary, Seime, T., additional, Witasp, A., additional, Karlöf, E., additional, Wasilewski, G., additional, Chartou, M., additional, Jaminon, A., additional, Kronqvist, M., additional, Lengquist, M., additional, Peeters, F.E.C.M., additional, Hultgren, R., additional, Roy, J., additional, Maegdefessel, L., additional, Arnardottir, H., additional, Stenvinkel, P., additional, Schurgers, L.J., additional, and Matic, L., additional

Published
2021
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22. Repression of MAP1LC3A during atherosclerosis progression plays an important role in the regulation of vascular smooth muscle cell phenotype

Author

Ehrenborg, E., primary, Paloschi, V., additional, Goncalves, I., additional, Saliba-Gustafsson, P., additional, Werngren, O., additional, Matic, L., additional, Skogsberg, J., additional, Jin, H., additional, Ketelhuth, D.F.J., additional, Maegdefessel, L., additional, Hedin, U., additional, Eriksson, P., additional, and Magné, J., additional

Published
2020
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25. Catalyzing transcriptomics research in cardiovascular disease:the CardioRNA COST Action CA17129

Author

Gomes, C. P. (Clarissa Pedrosa da Costa), Agg, B. (Bence), Andova, A. (Andrejaana), Arslan, S. (Serdal), Baker, A. (Andrew), Bartekova, M. (Monika), Beis, D. (Dimitris), Betsou, F. (Fay), Wettinger, S. B. (Stephanie Bezzina), Bugarski, B. (Branko), Condorelli, G. (Gianluigi), da Silva, G. J. (Gustavo Jose Justo), Danilin, S. (Sabrina), de Gonzalo-Calvo, D. (David), Buil, A. (Alfonso), Carmo-Fonseca, M. (Maria), Enguita, F. J. (Francisco J.), Felekkis, K. (Kyriacos), Ferdinandy, P. (Peter), Gyoengyoesi, M. (Mariann), Hackl, M. (Matthias), Karaduzovic-Hadziabdic, K. (Kanita), Hellemans, J. (Jan), Heymans, S. (Stephane), Hlavackova, M. (Marketa), Hoydal, M. A. (Morten Andre), Jankovic, A. (Aleksandra), Jusic, A. (Amela), Kardassis, D. (Dimitris), Kerkela, R. (Risto), Kuster, G. M. (Gabriela M.), Lakkisto, P. (Paivi), Leszek, P. (Przemyslaw), Lustrek, M. (Mitja), Maegdefessel, L. (Lars), Martelli, F. (Fabio), Novella, S. (Susana), O'Brien, T. (Timothy), Papaneophytou, C. (Christos), Pedrazzini, T. (Thierry), Pinet, F. (Florence), Popescu, O. (Octavian), Potocnjak, I. (Ines), Robinson, E. (Emma), Sasson, S. (Shlomo), Scholz, M. (Markus), Simionescu, M. (Maya), Stoll, M. (Monika), Varga, Z. V. (Zoltan V.), Vinciguerra, M. (Manlio), Xuereb, A. (Angela), Yilmaz, M. B. (Mehmet Birhan), Emanueli, C. (Costanza), Devaux, Y. (Yvan), Gomes, C. P. (Clarissa Pedrosa da Costa), Agg, B. (Bence), Andova, A. (Andrejaana), Arslan, S. (Serdal), Baker, A. (Andrew), Bartekova, M. (Monika), Beis, D. (Dimitris), Betsou, F. (Fay), Wettinger, S. B. (Stephanie Bezzina), Bugarski, B. (Branko), Condorelli, G. (Gianluigi), da Silva, G. J. (Gustavo Jose Justo), Danilin, S. (Sabrina), de Gonzalo-Calvo, D. (David), Buil, A. (Alfonso), Carmo-Fonseca, M. (Maria), Enguita, F. J. (Francisco J.), Felekkis, K. (Kyriacos), Ferdinandy, P. (Peter), Gyoengyoesi, M. (Mariann), Hackl, M. (Matthias), Karaduzovic-Hadziabdic, K. (Kanita), Hellemans, J. (Jan), Heymans, S. (Stephane), Hlavackova, M. (Marketa), Hoydal, M. A. (Morten Andre), Jankovic, A. (Aleksandra), Jusic, A. (Amela), Kardassis, D. (Dimitris), Kerkela, R. (Risto), Kuster, G. M. (Gabriela M.), Lakkisto, P. (Paivi), Leszek, P. (Przemyslaw), Lustrek, M. (Mitja), Maegdefessel, L. (Lars), Martelli, F. (Fabio), Novella, S. (Susana), O'Brien, T. (Timothy), Papaneophytou, C. (Christos), Pedrazzini, T. (Thierry), Pinet, F. (Florence), Popescu, O. (Octavian), Potocnjak, I. (Ines), Robinson, E. (Emma), Sasson, S. (Shlomo), Scholz, M. (Markus), Simionescu, M. (Maya), Stoll, M. (Monika), Varga, Z. V. (Zoltan V.), Vinciguerra, M. (Manlio), Xuereb, A. (Angela), Yilmaz, M. B. (Mehmet Birhan), Emanueli, C. (Costanza), and Devaux, Y. (Yvan)

Abstract

Cardiovascular disease (CVD) remains the leading cause of death worldwide and, despite continuous advances, better diagnostic and prognostic tools, as well as therapy, are needed. The human transcriptome, which is the set of all RNA produced in a cell, is much more complex than previously thought and the lack of dialogue between researchers and industrials and consensus on guidelines to generate data make it harder to compare and reproduce results. This European Cooperation in Science and Technology (COST) Action aims to accelerate the understanding of transcriptomics in CVD and further the translation of experimental data into usable applications to improve personalized medicine in this field by creating an interdisciplinary network. It aims to provide opportunities for collaboration between stakeholders from complementary backgrounds, allowing the functions of different RNAs and their interactions to be more rapidly deciphered in the cardiovascular context for translation into the clinic, thus fostering personalized medicine and meeting a current public health challenge. Thus, this Action will advance studies on cardiovascular transcriptomics, generate innovative projects, and consolidate the leadership of European research groups in the field. COST (European Cooperation in Science and Technology) is a funding organization for research and innovation networks (www.cost.eu).

Published
2019

31. P3199Long non-coding RNA H19 induces abdominal aortic aneurysms

Author

Li, D Y, primary, Busch, A, additional, Jin, H H, additional, Hofmann, P, additional, Boon, R A, additional, Pelisek, J, additional, Paloschi, V, additional, Roy, J, additional, Eckstein, H H, additional, Spin, J M, additional, Tsao, P S, additional, and Maegdefessel, L, additional

Published
2018
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33. Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation

Author

Stellos, K. Gatsiou, A. Stamatelopoulos, K. Perisic Matic, L. John, D. Lunella, F.F. Jaé, N. Rossbach, O. Amrhein, C. Sigala, F. Boon, R.A. Fürtig, B. Manavski, Y. You, X. Uchida, S. Keller, T. Boeckel, J.-N. Franco-Cereceda, A. Maegdefessel, L. Chen, W. Schwalbe, H. Bindereif, A. Eriksson, P. Hedin, U. Zeiher, A.M. Dimmeler, S.

Abstract

Adenosine-to-inosine (A-to-I) RNA editing, which is catalyzed by a family of adenosine deaminase acting on RNA (ADAR) enzymes, is important in the epitranscriptomic regulation of RNA metabolism. However, the role of A-to-I RNA editing in vascular disease is unknown. Here we show that cathepsin S mRNA (CTSS), which encodes a cysteine protease associated with angiogenesis and atherosclerosis, is highly edited in human endothelial cells. The 3′ untranslated region (3′ UTR) of the CTSS transcript contains two inverted repeats, the AluJo and AluSx + regions, which form a long stem-loop structure that is recognized by ADAR1 as a substrate for editing. RNA editing enables the recruitment of the stabilizing RNA-binding protein human antigen R (HuR; encoded by ELAVL1) to the 3′ UTR of the CTSS transcript, thereby controlling CTSS mRNA stability and expression. In endothelial cells, ADAR1 overexpression or treatment of cells with hypoxia or with the inflammatory-γ 3 and tumor-necrosis-factor-α induces CTSS RNA editing and consequently increases cathepsin S expression. ADAR1 levels and the extent of CTSS RNA editing are associated with changes in cathepsin S levels in patients with atherosclerotic vascular diseases, including subclinical atherosclerosis, coronary artery disease, aortic aneurysms and advanced carotid atherosclerotic disease. These results reveal a previously unrecognized role of RNA editing in gene expression in human atherosclerotic vascular diseases. © 2016 Nature America, Inc. All rights reserved.

Published
2016

35. Gene expression signatures, pathways and networks in carotid atherosclerosis

Author

Perisic, L., primary, Aldi, S., additional, Sun, Y., additional, Folkersen, L., additional, Razuvaev, A., additional, Roy, J., additional, Lengquist, M., additional, Åkesson, S., additional, Wheelock, C. E., additional, Maegdefessel, L., additional, Gabrielsen, A., additional, Odeberg, J., additional, Hansson, G. K., additional, Paulsson-Berne, G., additional, and Hedin, U., additional

Published
2015
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36. Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap

Author

Nurnberg, S.T., primary, Cheng, K., additional, Raiesdana, A., additional, Kundu, R., additional, Miller, C.L., additional, Kim, J.B., additional, Arora, K., additional, Carcamo-Oribe, I., additional, Xiong, Y., additional, Tellakula, N., additional, Nanda, V., additional, Murthy, N., additional, Boisvert, W.A., additional, Hedin, U., additional, Perisic, L., additional, Aldi, S., additional, Maegdefessel, L., additional, Pjanic, M., additional, Owens, G.K., additional, Tallquist, M.D., additional, and Quertermous, T., additional

Published
2015
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38. Coronary Allograft Arteriosclerosis: Local MicroRNA Modulation Using a Novel Anti-Mir-21-Eluting Stent Prevents in-Stent Restenosis

Author

Wang, D., primary, Deuse, T., additional, Stubbendorff, M., additional, Chernogubova, E., additional, Erben, R.G., additional, Eken, S.M., additional, Jin, H., additional, Heeger, C., additional, Behnisch, B., additional, Reichenspurner, H., additional, Robbins, R.C., additional, Spin, J.M., additional, Tsao, P.S., additional, Maegdefessel, L., additional, and Schrepfer, S., additional

Published
2015
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41. 356 Pyruvate Dehydrogenase Kinase 2 Controls Vascular Remodeling

Author

Deuse, T., primary, Hua, X., additional, Länger, F., additional, Gossler, T., additional, Stubbendorff, M., additional, Rakovic, A., additional, Klein, C., additional, Sutendra, G., additional, Dromparis, P., additional, Maegdefessel, L., additional, Tsao, P.S., additional, Velden, J., additional, Reichenspurner, H., additional, Robbins, R.C., additional, Haddad, F., additional, Michelakis, E., additional, and Schrepfer, S., additional

Published
2012
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42. Poster session 2

Author

Perez-Pomares, J. M., primary, Ruiz-Villalba, A., additional, Ziogas, A., additional, Segovia, J. C., additional, Ehrbar, M., additional, Munoz-Chapuli, R., additional, De La Rosa, A., additional, Dominguez, J. N., additional, Hove-Madsen, L., additional, Sankova, B., additional, Sedmera, D., additional, Franco, D., additional, Aranega Jimenez, A., additional, Babaeva, G., additional, Chizh, N., additional, Galchenko, S., additional, Sandomirsky, B., additional, Schwarzl, M., additional, Seiler, S., additional, Steendijk, P., additional, Huber, S., additional, Maechler, H., additional, Truschnig-Wilders, M., additional, Pieske, B., additional, Post, H., additional, Simrick, S., additional, Kreutzer, R., additional, Rao, C., additional, Terracciano, C. M., additional, Kirchhof, P., additional, Fabritz, L., additional, Brand, T., additional, Theveniau-Ruissy, M., additional, Parisot, P., additional, Francou, A., additional, Saint-Michel, E., additional, Mesbah, K., additional, Kelly, R. G., additional, Wu, H.-T., additional, Sie, S.-S., additional, Chen, C.-Y., additional, Kuan, T.-C., additional, Lin, C. S., additional, Ismailoglu, Z., additional, Guven, M., additional, Yakici, A., additional, Ata, Y., additional, Ozcan, S., additional, Yildirim, E., additional, Ongen, Z., additional, Miroshnikova, V., additional, Demina, E., additional, Rodygina, T., additional, Kurjanov, P., additional, Denisenko, A., additional, Schwarzman, A., additional, Rubanenko, A., additional, Shchukin, Y., additional, Germanov, A., additional, Goldbergova, M., additional, Parenica, J., additional, Lipkova, J., additional, Pavek, N., additional, Kala, P., additional, Poloczek, M., additional, Vasku, A., additional, Parenicova, I., additional, Spinar, J., additional, Gambacciani, C., additional, Chiavacci, E., additional, Evangelista, M., additional, Vesentini, N., additional, Kusmic, C., additional, Pitto, L., additional, Chernova, A., additional, Nikulina, S. U. Y., additional, Arvanitis, D. A., additional, Mourouzis, I., additional, Pantos, C., additional, Kranias, E. G., additional, Cokkinos, D. V., additional, Sanoudou, D., additional, Vladimirskaya, T. E., additional, Shved, I. A., additional, Kryvorot, S. G., additional, Schirmer, I. M., additional, Appukuttan, A., additional, Pott, L., additional, Jaquet, K., additional, Ladilov, Y., additional, Archer, C. R., additional, Bootman, M. D., additional, Roderick, H. L., additional, Fusco, A., additional, Sorriento, D., additional, Santulli, G., additional, Trimarco, B., additional, Iaccarino, G., additional, Hagenmueller, M., additional, Riffel, J., additional, Bernhold, E., additional, Katus, H. A., additional, Hardt, S. E., additional, Maqsood, A., additional, Zi, M., additional, Prehar, S., additional, Neyses, L., additional, Ray, S., additional, Oceandy, D., additional, Khatami, N., additional, Wadowski, P., additional, Wagh, V., additional, Hescheler, J., additional, Sachinidis, A., additional, Mohl, W., additional, Chaudhry, B., additional, Burns, D., additional, Henderson, D. J., additional, Bax, N. A. M., additional, Van Marion, M. H., additional, Shah, B., additional, Goumans, M. J., additional, Bouten, C. V. C., additional, Van Der Schaft, D. W. J., additional, Van Oorschot, A. A. M., additional, Maas, S., additional, Braun, J., additional, Van Tuyn, J., additional, De Vries, A. A. F., additional, Gittenberger-De Groot, A. C., additional, Bageghni, S., additional, Drinkhill, M. J., additional, Batten, T. F. C., additional, Ainscough, J. F. X., additional, Onate, B., additional, Vilahur, G., additional, Ferrer-Lorente, R., additional, Ybarra, J., additional, Diez-Caballero, A., additional, Ballesta-Lopez, C., additional, Moscatiello, F., additional, Herrero, J., additional, Badimon, L., additional, Martin-Rendon, E., additional, Clifford, D. M., additional, Fisher, S. A., additional, Brusnkill, S. J., additional, Doree, C., additional, Mathur, A., additional, Clarke, M., additional, Watt, S. M., additional, Hernandez-Vera, R., additional, Kavanagh, D., additional, Yemm, A. I., additional, Frampton, J., additional, Kalia, N., additional, Terajima, Y., additional, Shimizu, T., additional, Tsuruyama, S., additional, Ishii, H., additional, Sekine, H., additional, Hagiwara, N., additional, Okano, T., additional, Vrijsen, K. R., additional, Chamuleau, S. A. J., additional, Sluijter, J. P. G., additional, Doevendans, P. F. M., additional, Madonna, R., additional, Delli Pizzi, S., additional, Di Donato, L., additional, Mariotti, A., additional, Di Carlo, L., additional, D'ugo, E., additional, Teberino, M. A., additional, Merla, A., additional, T, A., additional, De Caterina, R., additional, Kolker, L., additional, Ali, N. N., additional, Maclellan, K., additional, Moore, M., additional, Wheeler, J., additional, Harding, S. E., additional, Fleck, R. A., additional, Rowlinson, J. M., additional, Kraenkel, N., additional, Ascione, R., additional, Madeddu, P., additional, O'sullivan, J. F., additional, Leblond, A. L., additional, Kelly, G., additional, Kumar, A. H. S., additional, Metharom, P., additional, Buneker, C. K., additional, Alizadeh-Vikali, N., additional, Hynes, B. G., additional, O'connor, R., additional, Caplice, N. M., additional, Noseda, M., additional, De Smith, A. J., additional, Leja, T., additional, Rao, P. H., additional, Al-Beidh, F., additional, Abreu Pavia, M. S., additional, Blakemore, A. I., additional, Schneider, M. D., additional, Stathopoulou, K., additional, Cuello, F., additional, Ehler, E., additional, Haworth, R. S., additional, Avkiran, M., additional, Morawietz, H., additional, Eickholt, C., additional, Langbein, H., additional, Brux, M., additional, Goettsch, C., additional, Goettsch, W., additional, Arsov, A., additional, Brunssen, C., additional, Mazilu, L., additional, Parepa, I. R., additional, Suceveanu, A. I., additional, Suceveanu, A. P., additional, De Man, F. S., additional, Guignabert, C., additional, Tu, L., additional, Handoko, M. L., additional, Schalij, I., additional, Fadel, E., additional, Postmus, P. E., additional, Vonk-Noordegraaf, A., additional, Humbert, M., additional, Eddahibi, S., additional, Del Giudice, C., additional, Anastasio, A., additional, Fazal, L., additional, Azibani, F., additional, Bihry, N., additional, Merval, R., additional, Polidano, E., additional, Samuel, J.-L., additional, Delcayre, C., additional, Zhang, Y., additional, Mi, Y. M., additional, Ren, L. L., additional, Cheng, Y. P., additional, Guo, R., additional, Liu, Y., additional, Jiang, Y. N., additional, Kokkinos, A. 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Published
2012
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45. Pyruvate dehydrogenase kinase 2 controls the development of intimal hyperplasia

Author

Deuse, T, primary, Hua, X, additional, Laenger, F, additional, Gossler, T, additional, Stubbendorff, M, additional, Rakovic, A, additional, Klein, C, additional, Sutendra, G, additional, Dromparis, P, additional, Maegdefessel, L, additional, Tsao, PS, additional, Velden, J, additional, Reichenspurner, H, additional, Robbins, RC, additional, Haddad, F, additional, Michelakis, E, additional, and Schrepfer, S, additional

Published
2012
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48. The emerging role of micro RNAs in cardiovascular disease.

Author

Maegdefessel, L.

Subjects
*MICRORNA, *CARDIOVASCULAR disease treatment, *MYOCARDIAL infarction, *BIOMARKERS, *MORTALITY, *STROKE, *THERAPEUTICS
Abstract

Cardiovascular disease remains the most prevalent cause of human morbidity and mortality in ageing Western societies. Basic and translational scientific efforts have focused on the development and improvement of diagnostic and therapeutic strategies to limit the burden of associated diseases, such as stroke and myocardial infarction, and diabetes mellitus and arterial hypertension. Progress in molecular medicine and biology has unravelled a complex epigenetic and post-transcriptional gene-regulating machinery in humans which may limit disease development. An increasing number of attractive molecular strategies, which use the potential of modulating noncoding RNAs, have surfaced over the last decade. Currently, the most extensively studied gene-regulating RNA subspecies are micro RNAs, which have been shown to adjust the translational output of coding transcripts by enforcing their degradation and inhibiting their translation into protein. Key findings indicate that micro RNAs act as crucial regulators in the majority of human pathologies. Thus, recent research has focused on detecting and modulating micro RNAs for therapeutic and biomarker purposes. This review focuses on main and repeated discoveries regarding the role and the therapeutic and biomarker feasibility of micro RNAs during cardiovascular disease development and exacerbation. [ABSTRACT FROM AUTHOR]

Published
2014
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