Search

Your search keyword '"Maeder, Philippe"' showing total 745 results
Start Over Author "Maeder, Philippe"
745 results on '"Maeder, Philippe"'

2. Differentiating MYCN-amplified RB1 wild-type retinoblastoma from biallelic RB1 mutant retinoblastoma using MR-based radiomics: a retrospective multicenter case–control study

Author

de Bloeme , Christiaan M., Jansen, Robin W., Cardoen, Liesbeth, Göricke, Sophia, van Elst, Sabien, Jessen, Jaime Lyn, Ramasubramanian, Aparna, Skalet, Alison H., Miller, Audra K., Maeder, Philippe, Uner, Ogul E., Hubbard, G. Baker, Grossniklaus, Hans, Boldt, H. Culver, Nichols, Kim E., Brennan, Rachel C., Sen, Saugata, Koob, Mériam, Sirin, Selma, Brisse, Hervé J., Galluzzi, Paolo, Dommering, Charlotte J., Cysouw, Matthijs, Boellaard, Ronald, Dorsman, Josephine C., Moll, Annette C., de Jong, Marcus C., and de Graaf, Pim

Published
2024
Full Text
View/download PDF

3. Correlation of gene expression with magnetic resonance imaging features of retinoblastoma: a multi-center radiogenomics validation study

Author

Jansen, Robin W., Roohollahi, Khashayar, Uner, Ogul E., de Jong, Yvonne, de Bloeme, Christiaan M., Göricke, Sophia, Sirin, Selma, Maeder, Philippe, Galluzzi, Paolo, Brisse, Hervé J., Cardoen, Liesbeth, Castelijns, Jonas A., van der Valk, Paul, Moll, Annette C., Grossniklaus, Hans, Hubbard, G. Baker, de Jong, Marcus C., Dorsman, Josephine, and de Graaf, Pim

Published
2024
Full Text
View/download PDF

11. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Harkness, Kirsty, Shaw, Louise, Sword, Jane, Mohd Nor, Azlisham, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Birns, Jonathan, Cohen, David, Sekaran, Lakshmanan, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O'Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, Sprigg, Nikola, O'Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas, Vahidassr, Djamil, Shakeshaft, Clare, Brown, Martin, Charidimou, Andreas, Cohen, Hannah, Banerjee, Gargi, Houlden, Henry, White, Mark, Yousry, Tarek, Flossmann, Enrico, Muir, Keith, Gratz, Pascal, Mattle, Heinrich, Panos, Leonidas, Korczyn, Amos, Kliper, Efrat, Maeder, Philippe, Gass, Achim, Pachai, Chahin, Bracoub, Luc, Douste-Blazy, Marie-Yvonne, Fratacci, Marie Dominique, Vicaut, Eric, Sato, Shoichiro, Miwa, Kaori, Fujita, Kyohei, Ide, Toshihiro, Ma, Henry, Ly, John, Singhal, Shaloo, Chandra, Ronil, Slater, Lee-Anne, Soufan, Cathy, Moran, Christopher, Traenka, Christopher, Thilemann, Sebastian, Fladt, Joachim, Gensicke, Henrik, Bonati, Leo, Kim, Beom Joon, Han, Moon-Ku, Kang, Jihoon, Ko, Eunbin, Yang, Mi Hwa, Jang, Myung Suk, Murphy, Sean, Carty, Fiona, Akijian, Layan, Thornton, John, Schembri, Mark, Douven, Elles, Delgado-Mederos, Raquel, Marín, Rebeca, Camps-Renom, Pol, Guisado-Alonso, Daniel, Nuñez, Fidel, Medrano-Martorell, Santiago, Merino, Elisa, Iida, Kotaro, Ikeda, Syuhei, Irie, Hiroyuki, Demirelli, Derya Selcuk, Medanta, Jayesh Modi, Zerna, Charlotte, Hernández, Maria Valdés, Armitage, Paul, Heye, Anna, Muñoz-Maniega, Susana, Sakka, Eleni, Thrippleton, Michael, Dennis, Martin, Beigneux, Ysoline, Silva, Mauro, Venketasubramanian, Narayanaswamy, Ho, Shu Leung, Cheung, Raymond Tak Fai, Chan, Koon Ho, Teo, Kay Cheong, Hui, Edward, Kwan, Joseph Shiu Kwong, Chang, Richard, Tse, Man Yu, Hoi, Chu Peng, Chan, Chung Yan, Chan, Oi Ling, Cheung, Ryan Hoi Kit, Wong, Edmund Ka Ming, Leung, Kam Tat, Tsang, Suk Fung, Ip, Hing Lung, Ma, Sze Ho, Ma, Karen, Fong, Wing Chi, Li, Siu Hung, Li, Richard, Ng, Ping Wing, Wong, Kwok Kui, Liu, Wenyan, Wong, Lawrence, Ramos, Lino, De Schryver, Els, Jöbsis, Joost, van der Sande, Jaap, Brouwers, Paul, Roos, Yvo, Stam, Jan, Bakker, Stef, Verbiest, Henk, Schoonewille, Wouter, Linn, Cisca, Hertzberger, Leopold, van Gemert, Maarten, Berntsen, Paul, Van Dam-Nolen, Dianne, Kooi, M Eline, Van der Lugt, Aad, Koudstaal, Peter, Leff, Alexander, Ward, Nicholas, Nachev, Parashkev, Perry, Richard, Ozkan, Hatice, Mitchell, John, Best, Jonathan G, Ambler, Gareth, Wilson, Duncan, Lee, Keon-Joo, Lim, Jae-Sung, Shiozawa, Masayuki, Koga, Masatoshi, Li, Linxin, Lovelock, Caroline, Chabriat, Hugues, Hennerici, Michael, Wong, Yuen Kwun, Mak, Henry Ka Fung, Prats-Sanchez, Luis, Martínez-Domeño, Alejandro, Inamura, Shigeru, Yoshifuji, Kazuhisa, Arsava, Ethem Murat, Horstmann, Solveig, Purrucker, Jan, Lam, Bonnie Yin Ka, Wong, Adrian, Kim, Young Dae, Song, Tae-Jin, Lemmens, Robin, Eppinger, Sebastian, Gattringer, Thomas, Uysal, Ender, Tanriverdi, Zeynep, Bornstein, Natan M, Ben Assayag, Einor, Hallevi, Hen, Molad, Jeremy, Nishihara, Masashi, Tanaka, Jun, Coutts, Shelagh B, Polymeris, Alexandros, Wagner, Benjamin, Seiffge, David J, Lyrer, Philippe, Algra, Ale, Kappelle, L Jaap, Al-Shahi Salman, Rustam, Jäger, Hans R, Lip, Gregory Y H, Fischer, Urs, El-Koussy, Marwan, Mas, Jean-Louis, Legrand, Laurence, Karayiannis, Christopher, Phan, Thanh, Gunkel, Sarah, Christ, Nicolas, Abrigo, Jill, Leung, Thomas, Chu, Winnie, Chappell, Francesca, Makin, Stephen, Hayden, Derek, Williams, David J, Mess, Werner H, Nederkoorn, Paul J, Barbato, Carmen, Browning, Simone, Wiegertjes, Kim, Tuladhar, Anil M, Maaijwee, Noortje, Guevarra, Anne Cristine, Yatawara, Chathuri, Mendyk, Anne-Marie, Delmaire, Christine, Köhler, Sebastian, van Oostenbrugge, Robert, Zhou, Ying, Xu, Chao, Hilal, Saima, Gyanwali, Bibek, Chen, Christopher, Lou, Min, Staals, Julie, Bordet, Régis, Kandiah, Nagaendran, de Leeuw, Frank-Erik, Simister, Robert, Hendrikse, Jeroen, Kelly, Peter J, Wardlaw, Joanna, Soo, Yannie, Fluri, Felix, Srikanth, Velandai, Calvet, David, Jung, Simon, Kwa, Vincent I H, Engelter, Stefan T, Peters, Nils, Smith, Eric E, Hara, Hideo, Yakushiji, Yusuke, Orken, Dilek Necioglu, Fazekas, Franz, Thijs, Vincent, Heo, Ji Hoe, Mok, Vincent, Veltkamp, Roland, Ay, Hakan, Imaizumi, Toshio, Gomez-Anson, Beatriz, Lau, Kui Kai, Jouvent, Eric, Rothwell, Peter M, Toyoda, Kazunori, Bae, Hee-Joon, Marti-Fabregas, Joan, and Werring, David J

Published
2021
Full Text
View/download PDF

12. Follow-up of Cystic Pineal Glands in Retinoblastoma Patients Does Not Increase Detection of Pineal Trilateral Retinoblastoma

Author

de Bloeme, Christiaan M; https://orcid.org/0000-0002-4901-0301, Jansen, Robin W; https://orcid.org/0000-0003-0347-1919, de Haan, Joeka; https://orcid.org/0009-0008-3050-6703, Pieperjohanns, Debbie, Casseri, Tommaso, Gironi, Federica, Pasca, Alessandra, Ketteler, Petra; https://orcid.org/0000-0002-8138-0441, Moll, Annette C; https://orcid.org/0000-0002-9313-8345, Koob, Meriam, Sirin, Selma; https://orcid.org/0000-0003-4555-0367, Maeder, Philippe; https://orcid.org/0000-0002-2875-4889, Galluzzi, Paolo; https://orcid.org/0000-0002-7553-5064, Göricke, Sophia, de Graaf, Pim; https://orcid.org/0000-0003-1938-0747, de Jong, Marcus C; https://orcid.org/0000-0002-8524-5108, European Retinoblastoma Imaging Collaboration, de Bloeme, Christiaan M; https://orcid.org/0000-0002-4901-0301, Jansen, Robin W; https://orcid.org/0000-0003-0347-1919, de Haan, Joeka; https://orcid.org/0009-0008-3050-6703, Pieperjohanns, Debbie, Casseri, Tommaso, Gironi, Federica, Pasca, Alessandra, Ketteler, Petra; https://orcid.org/0000-0002-8138-0441, Moll, Annette C; https://orcid.org/0000-0002-9313-8345, Koob, Meriam, Sirin, Selma; https://orcid.org/0000-0003-4555-0367, Maeder, Philippe; https://orcid.org/0000-0002-2875-4889, Galluzzi, Paolo; https://orcid.org/0000-0002-7553-5064, Göricke, Sophia, de Graaf, Pim; https://orcid.org/0000-0003-1938-0747, de Jong, Marcus C; https://orcid.org/0000-0002-8524-5108, and European Retinoblastoma Imaging Collaboration

Abstract

PURPOSE To evaluate the effectiveness of baseline screening and follow-up with magnetic resonance imaging (MRI) for detecting trilateral retinoblastoma (TRb) and assessing the risk of TRb development. DESIGN Prospective multicenter cohort study. METHODS A total of 607 retinoblastoma patients from 2012 through 2022 were included and followed up until September 1, 2023. At each center, a neuroradiologist categorized pineal glands on baseline and follow-up scans into 4 groups: (A) normal, (B) cystic gland, (C) suspicious gland, or (D) TRb. Different follow-up schedules were assigned to each category. Categories B and C were followed up with MRI after approximately 3 months and repeated 3 months later if suspicion remained. On each MRI, they measured the height and width, evaluated the aspect (solid, partly cystic, and completely cystic) of the pineal gland, and evaluated radiologic features suspicious of pineal TRb. The effectiveness of the current TRb screening method was assessed by evaluating its sensitivity and specificity to detect TRb. Determining the TRb incidence was a secondary outcome measure. RESULTS Heritable retinoblastoma patients had a risk of 3.78% to develop TRb. One of 4 pineal TRbs was detected during a follow-up scan and 4 of 5 nonpineal TRbs were detected on the baseline MRI. Screening for pineal TRb had a sensitivity of 25% and specificity of 100%; for nonpineal TRb, the sensitivity was 80%. It required 494 follow-up scans to detect 1 pineal TRb. However, when restricting the follow-up to solely suspicious glands, only 22 scans were required to detect 1 pineal TRb. CONCLUSION During extended follow-up after baseline MRI, only 1 pineal trilateral retinoblastoma was detected in our study. Follow-up after 3 months should be restricted to patients with a suspicious pineal gland defined as irregular thickening of the cyst wall (>2 mm), fine nodular aspect of the cyst wall, or when a solid or cystic gland exceeds the upper 99% prediction interval for si

Published
2024

13. Differentiating MYCN-amplified RB1 wild-type retinoblastoma from biallelic RB1 mutant retinoblastoma using MR-based radiomics: a retrospective multicenter case-control study

Author

de Bloeme, Christiaan M; https://orcid.org/0000-0002-4901-0301, Jansen, Robin W; https://orcid.org/0000-0003-0347-1919, Cardoen, Liesbeth; https://orcid.org/0000-0001-7842-8638, Göricke, Sophia, van Elst, Sabien; https://orcid.org/0000-0003-2784-1988, Jessen, Jaime Lyn, Ramasubramanian, Aparna, Skalet, Alison H, Miller, Audra K; https://orcid.org/0000-0003-2774-6059, Maeder, Philippe; https://orcid.org/0000-0002-2875-4889, Uner, Ogul E; https://orcid.org/0000-0002-8730-6859, Hubbard, G Baker; https://orcid.org/0000-0001-5427-438X, Grossniklaus, Hans, Boldt, H Culver; https://orcid.org/0000-0002-7292-2093, Nichols, Kim E; https://orcid.org/0000-0002-5581-6555, Brennan, Rachel C; https://orcid.org/0000-0002-2090-4395, Sen, Saugata; https://orcid.org/0000-0002-0418-712X, Koob, Mériam, Sirin, Selma; https://orcid.org/0000-0003-4555-0367, Brisse, Hervé J; https://orcid.org/0000-0003-2794-5875, Galluzzi, Paolo; https://orcid.org/0000-0002-7553-5064, Dommering, Charlotte J; https://orcid.org/0000-0001-5565-7526, Cysouw, Matthijs, Boellaard, Ronald; https://orcid.org/0000-0002-0313-5686, Dorsman, Josephine C, Moll, Annette C; https://orcid.org/0000-0002-9313-8345, de Jong, Marcus C; https://orcid.org/0000-0002-8524-5108, de Graaf, Pim; https://orcid.org/0000-0003-1938-0747, European Retinoblastoma Imaging Collaboration, de Bloeme, Christiaan M; https://orcid.org/0000-0002-4901-0301, Jansen, Robin W; https://orcid.org/0000-0003-0347-1919, Cardoen, Liesbeth; https://orcid.org/0000-0001-7842-8638, Göricke, Sophia, van Elst, Sabien; https://orcid.org/0000-0003-2784-1988, Jessen, Jaime Lyn, Ramasubramanian, Aparna, Skalet, Alison H, Miller, Audra K; https://orcid.org/0000-0003-2774-6059, Maeder, Philippe; https://orcid.org/0000-0002-2875-4889, Uner, Ogul E; https://orcid.org/0000-0002-8730-6859, Hubbard, G Baker; https://orcid.org/0000-0001-5427-438X, Grossniklaus, Hans, Boldt, H Culver; https://orcid.org/0000-0002-7292-2093, Nichols, Kim E; https://orcid.org/0000-0002-5581-6555, Brennan, Rachel C; https://orcid.org/0000-0002-2090-4395, Sen, Saugata; https://orcid.org/0000-0002-0418-712X, Koob, Mériam, Sirin, Selma; https://orcid.org/0000-0003-4555-0367, Brisse, Hervé J; https://orcid.org/0000-0003-2794-5875, Galluzzi, Paolo; https://orcid.org/0000-0002-7553-5064, Dommering, Charlotte J; https://orcid.org/0000-0001-5565-7526, Cysouw, Matthijs, Boellaard, Ronald; https://orcid.org/0000-0002-0313-5686, Dorsman, Josephine C, Moll, Annette C; https://orcid.org/0000-0002-9313-8345, de Jong, Marcus C; https://orcid.org/0000-0002-8524-5108, de Graaf, Pim; https://orcid.org/0000-0003-1938-0747, and European Retinoblastoma Imaging Collaboration

Abstract

MYCN-amplified RB1 wild-type (MYCN$^{amp}$RB1$^{+/+}$) retinoblastoma is a rare and aggressive subtype, often resistant to standard therapies. Identifying unique MRI features is crucial for diagnosing this subtype, as biopsy is not recommended. This study aimed to differentiate MYCN$^{amp}$RB1$^{+/+}$ from the most prevalent RB1$^{-/-}$ retinoblastoma using pretreatment MRI and radiomics. Ninety-eight unilateral retinoblastoma patients (19 MYCN cases and 79 matched controls) were included. Tumors on T2-weighted MR images were manually delineated and validated by experienced radiologists. Radiomics analysis extracted 120 features per tumor. Several combinations of feature selection methods, oversampling techniques and machine learning (ML) classifiers were evaluated in a repeated fivefold cross-validation machine learning pipeline to yield the best-performing prediction model for MYCN. The best model used univariate feature selection, data oversampling (duplicating MYCN cases), and logistic regression classifier, achieving a mean AUC of 0.78 (SD 0.12). SHAP analysis highlighted lower sphericity, higher flatness, and greater gray-level heterogeneity as predictive for MYCN$^{amp}$RB1$^{+/+}$ status, yielding an AUC of 0.81 (SD 0.11). This study shows the potential of MRI-based radiomics to distinguish MYCN$^{amp}$RB1$^{+/+}$ and RB1$^{-/-}$ retinoblastoma subtypes.

Published
2024

14. MR Imaging of Adverse Effects and Ocular Growth Decline after Selective Intra-Arterial Chemotherapy for Retinoblastoma

Author

de Bloeme, Christiaan M; https://orcid.org/0000-0002-4901-0301, van Elst, Sabien; https://orcid.org/0000-0003-2784-1988, Galluzzi, Paolo; https://orcid.org/0000-0002-7553-5064, Jansen, Robin W; https://orcid.org/0000-0003-0347-1919, de Haan, Joeka; https://orcid.org/0009-0008-3050-6703, Göricke, Sophia, Moll, Annette C; https://orcid.org/0000-0002-9313-8345, Bot, Joseph C J, Munier, Francis L; https://orcid.org/0000-0002-8928-1050, Beck-Popovic, Maja; https://orcid.org/0000-0001-9502-5697, Puccinelli, Francesco, Aerts, Isabelle, Hadjistilianou, Theodora, Sirin, Selma; https://orcid.org/0000-0003-4555-0367, Koob, Mériam, Brisse, Hervé J; https://orcid.org/0000-0003-2794-5875, Cardoen, Liesbeth; https://orcid.org/0000-0001-7842-8638, Maeder, Philippe; https://orcid.org/0000-0002-2875-4889, de Jong, Marcus C; https://orcid.org/0000-0002-8524-5108, de Graaf, Pim; https://orcid.org/0000-0003-1938-0747, de Bloeme, Christiaan M; https://orcid.org/0000-0002-4901-0301, van Elst, Sabien; https://orcid.org/0000-0003-2784-1988, Galluzzi, Paolo; https://orcid.org/0000-0002-7553-5064, Jansen, Robin W; https://orcid.org/0000-0003-0347-1919, de Haan, Joeka; https://orcid.org/0009-0008-3050-6703, Göricke, Sophia, Moll, Annette C; https://orcid.org/0000-0002-9313-8345, Bot, Joseph C J, Munier, Francis L; https://orcid.org/0000-0002-8928-1050, Beck-Popovic, Maja; https://orcid.org/0000-0001-9502-5697, Puccinelli, Francesco, Aerts, Isabelle, Hadjistilianou, Theodora, Sirin, Selma; https://orcid.org/0000-0003-4555-0367, Koob, Mériam, Brisse, Hervé J; https://orcid.org/0000-0003-2794-5875, Cardoen, Liesbeth; https://orcid.org/0000-0001-7842-8638, Maeder, Philippe; https://orcid.org/0000-0002-2875-4889, de Jong, Marcus C; https://orcid.org/0000-0002-8524-5108, and de Graaf, Pim; https://orcid.org/0000-0003-1938-0747

Abstract

This retrospective multicenter study examines therapy-induced orbital and ocular MRI findings in retinoblastoma patients following selective intra-arterial chemotherapy (SIAC) and quantifies the impact of SIAC on ocular and optic nerve growth. Patients were selected based on medical chart review, with inclusion criteria requiring the availability of posttreatment MR imaging encompassing T2-weighted and T1-weighted images (pre- and post-intravenous gadolinium administration). Qualitative features and quantitative measurements were independently scored by experienced radiologists, with deep learning segmentation aiding total eye volume assessment. Eyes were categorized into three groups: eyes receiving SIAC (Rb-SIAC), eyes treated with other eye-saving methods (Rb-control), and healthy eyes. The most prevalent adverse effects post-SIAC were inflammatory and vascular features, with therapy-induced contrast enhancement observed in the intraorbital optic nerve segment in 6% of patients. Quantitative analysis revealed significant growth arrest in Rb-SIAC eyes, particularly when treatment commenced ≤ 12 months of age. Optic nerve atrophy was a significant complication in Rb-SIAC eyes. In conclusion, this study highlights the vascular and inflammatory adverse effects observed post-SIAC in retinoblastoma patients and demonstrates a negative impact on eye and optic nerve growth, particularly in children treated ≤ 12 months of age, providing crucial insights for clinical management and future research.

Published
2024

16. Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Author

Munier, Francis L., Beck-Popovic, Maja, Chantada, Guillermo L., Cobrinik, David, Kivelä, Tero T., Lohmann, Dietmar, Maeder, Philippe, Moll, Annette C., Carcaboso, Angel Montero, Moulin, Alexandre, Schaiquevich, Paula, Bergin, Ciara, Dyson, Paul J., Houghton, Susan, Puccinelli, Francesco, Vial, Yvan, Gaillard, Marie-Claire, and Stathopoulos, Christina

Published
2019
Full Text
View/download PDF

17. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Harkness, Kirsty, Shaw, Louise, Sword, Jane, Mohd Nor, Azlisham, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Birns, Jonathan, Cohen, David, Sekaran, Lakshmanan, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O'Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, Sprigg, Nikola, O'Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas, Vahidassr, Djamil, Shakeshaft, Clare, Brown, Martin, Charidimou, Andreas, Cohen, Hannah, Banerjee, Gargi, Houlden, Henry, White, Mark, Yousry, Tarek, Flossmann, Enrico, Muir, Keith, El-Koussy, Marwan, Gratz, Pascal, Molad, Jeremy, Korczyn, Amos, Kliper, Efrat, Maeder, Philippe, Gass, Achim, Pachai, Chahin, Bracoub, Luc, Douste-Blazy, Marie-Yvonne, Fratacci, Marie Dominique, Vicaut, Eric, Sato, Shoichiro, Miwa, Kaori, Fujita, Kyohei, Ide, Toshihiro, Ma, Henry, Ly, John, Singhal, Shahoo, Chandra, Ronil, Slater, Lee-Anne, Soufan, Cathy, Moran, Christopher, Traenka, Christopher, Thilemann, Sebastian, Fladt, Joachim, Gensicke, Henrik, Bonati, Leo, Kim, Beom Joon, Han, Moon-Ku, Kang, Jihoon, Ko, Eunbin, Yang, Mi Hwa, Jang, Myung Suk, Murphy, Sean, Carty, Fiona, Akijian, Layan, Thornton, John, Schembri, Mark, Douven, Elles, Delgado-Mederos;, Raquel, Marín, Rebeca, Camps-Renom, Pol, Guisado-Alonso, Daniel, Nuñez, Fidel, Medrano-Martorell, Santiago, Merino, Elisa, Iida, Kotaro, Ikeda, Syuhei, Nishihara, Masashi, Irie, Hiroyuki, Demirelli, Derya Selcuk, Medanta, Jayesh Modi, Zerna, Charlotte, Hernández, Maria Valdés, Armitage, Paul, Heye, Anna, Muñoz-Maniega, Susana, Sakka, Eleni, Thrippleton, Michael, Dennis, Martin, Beigneux, Ysoline, Silva, Mauro, Venketasubramanian, Narayanaswamy, Ho, Shu Leung, Cheung, Raymond Tak Fai, Chan, Koon Ho, Teo, Kay Cheong, Hui, Edward, Kwan, Joseph Shiu Kwong, Chang, Richard, Tse, Man Yu, Hoi, Chu Peng, Chan, Chung Yan, Chan, Oi Ling, Cheung, Ryan Hoi Kit, Wong, Edmund Ka Ming, Leung, Kam Tat, Tsang, Suk Fung, Ip, Hing Lung, Ma, Sze Ho, Ma, Karen, Fong, Wing Chi, Li, Siu Hung, Li, Richard, Ng, Ping Wing, Wong, Kwok Kui, Liu, Wenyan, Wong, Lawrence, Ramos, Lino, De Schryver, Els, Jöbsis, Joost, van der Sande, Jaap, Brouwers, Paul, Roos, Yvo, Stam, Jan, Bakker, Stef, Verbiest, Henk, Schoonewille, Wouter, Linn, Cisca, Hertzberger, Leopold, van Gemert, Maarten, Berntsen, Paul, Hendrikse, Jeroen, Nederkoorn, Paul, Mess, Werner, Koudstaal, Peter, Leff, Alexander, Ward, Nicholas, Nachev, Parashkev, Perry, Richard, Ozkan, Hatice, Mitchell, John, Wilson, Duncan, Ambler, Gareth, Lee, Keon-Joo, Lim, Jae-Sung, Shiozawa, Masayuki, Koga, Masatoshi, Li, Linxin, Lovelock, Caroline, Chabriat, Hugues, Hennerici, Michael, Wong, Yuen Kwun, Mak, Henry Ka Fung, Prats-Sánchez, Luis, Martínez-Domeño, Alejandro, Inamura, Shigeru, Yoshifuji, Kazuhisa, Arsava, Ethem Murat, Horstmann, Solveig, Purrucker, Jan, Lam, Bonnie Yin Ka, Wong, Adrian, Kim, Young Dae, Song, Tae-Jin, Schrooten, Maarten, Lemmens, Robin, Eppinger, Sebastian, Gattringer, Thomas, Uysal, Ender, Tanriverdi, Zeynep, Bornstein, Natan M, Assayag, Einor Ben, Hallevi, Hen, Tanaka, Jun, Hara, Hideo, Coutts, Shelagh B, Hert, Lisa, Polymeris, Alexandros, Seiffge, David J, Lyrer, Philippe, Algra, Ale, Kappelle, Jaap, Al-Shahi Salman, Rustam, Jäger, Hans R, Lip, Gregory Y H, Mattle, Heinrich P, Panos, Leonidas D, Mas, Jean-Louis, Legrand, Laurence, Karayiannis, Christopher, Phan, Thanh, Gunkel, Sarah, Christ, Nicolas, Abrigo, Jill, Leung, Thomas, Chu, Winnie, Chappell, Francesca, Makin, Stephen, Hayden, Derek, Williams, David J, Kooi, M Eline, van Dam-Nolen, Dianne H K, Barbato, Carmen, Browning, Simone, Wiegertjes, Kim, Tuladhar, Anil M, Maaijwee, Noortje, Guevarra, Christine, Yatawara, Chathuri, Mendyk, Anne-Marie, Delmaire, Christine, Köhler, Sebastian, van Oostenbrugge, Robert, Zhou, Ying, Xu, Chao, Hilal, Saima, Gyanwali, Bibek, Chen, Christopher, Lou, Min, Staals, Julie, Bordet, Régis, Kandiah, Nagaendran, de Leeuw, Frank-Erik, Simister, Robert, van der Lugt, Aad, Kelly, Peter J, Wardlaw, Joanna M, Soo, Yannie, Fluri, Felix, Srikanth, Velandai, Calvet, David, Jung, Simon, Kwa, Vincent I H, Engelter, Stefan T, Peters, Nils, Smith, Eric E, Yakushiji, Yusuke, Orken, Dilek Necioglu, Fazekas, Franz, Thijs, Vincent, Heo, Ji Hoe, Mok, Vincent, Veltkamp, Roland, Ay, Hakan, Imaizumi, Toshio, Gomez-Anson, Beatriz, Lau, Kui Kai, Jouvent, Eric, Rothwell, Peter M, Toyoda, Kazunori, Bae, Hee-Joon, Marti-Fabregas, Joan, and Werring, David J

Published
2019
Full Text
View/download PDF

18. Pituitary blastoma: a pathognomonic feature of germ-line DICER1 mutations

Author

de Kock, Leanne, Sabbaghian, Nelly, Plourde, François, Srivastava, Archana, Weber, Evan, Bouron-Dal Soglio, Dorothée, Hamel, Nancy, Choi, Joon Hyuk, Park, Sung-Hye, Deal, Cheri L, Kelsey, Megan M, Dishop, Megan K, Esbenshade, Adam, Kuttesch, John F, Jacques, Thomas S, Perry, Arie, Leichter, Heinz, Maeder, Philippe, Brundler, Marie-Anne, Warner, Justin, Neal, James, Zacharin, Margaret, Korbonits, Márta, Cole, Trevor, Traunecker, Heidi, McLean, Thomas W, Rotondo, Fabio, Lepage, Pierre, Albrecht, Steffen, Horvath, Eva, Kovacs, Kalman, Priest, John R, and Foulkes, William D

Subjects
Biomedical and Clinical Sciences, Neurosciences, Genetic Testing, Cancer, Clinical Research, Rare Diseases, Pediatric, Genetics, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Child, Preschool, DEAD-box RNA Helicases, DNA Mutational Analysis, Fatal Outcome, Germ-Line Mutation, Humans, Immunohistochemistry, Infant, Magnetic Resonance Imaging, Mutation, Neoplasms, Complex and Mixed, Pedigree, Pituitary Neoplasms, Radiography, Thoracic, Ribonuclease III, Tomography, X-Ray Computed, Treatment Outcome, Clinical Sciences, Neurology & Neurosurgery
Abstract

Individuals harboring germ-line DICER1 mutations are predisposed to a rare cancer syndrome, the DICER1 Syndrome or pleuropulmonary blastoma-familial tumor and dysplasia syndrome [online Mendelian inheritance in man (OMIM) #601200]. In addition, specific somatic mutations in the DICER1 RNase III catalytic domain have been identified in several DICER1-associated tumor types. Pituitary blastoma (PitB) was identified as a distinct entity in 2008, and is a very rare, potentially lethal early childhood tumor of the pituitary gland. Since the discovery by our team of an inherited mutation in DICER1 in a child with PitB in 2011, we have identified 12 additional PitB cases. We aimed to determine the contribution of germ-line and somatic DICER1 mutations to PitB. We hypothesized that PitB is a pathognomonic feature of a germ-line DICER1 mutation and that each PitB will harbor a second somatic mutation in DICER1. Lymphocyte or saliva DNA samples ascertained from ten infants with PitB were screened and nine were found to harbor a heterozygous germ-line DICER1 mutation. We identified additional DICER1 mutations in nine of ten tested PitB tumor samples, eight of which were confirmed to be somatic in origin. Seven of these mutations occurred within the RNase IIIb catalytic domain, a domain essential to the generation of 5p miRNAs from the 5' arm of miRNA-precursors. Germ-line DICER1 mutations are a major contributor to PitB. Second somatic DICER1 "hits" occurring within the RNase IIIb domain also appear to be critical in PitB pathogenesis.

Published
2014

19. Ocular Structures Segmentation from Multi-sequences MRI Using 3D Unet with Fully Connected CRFs

Author

Nguyen, Huu-Giao, Pica, Alessia, Maeder, Philippe, Schalenbourg, Ann, Peroni, Marta, Hrbacek, Jan, Weber, Damien C., Cuadra, Meritxell Bach, Sznitman, Raphael, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Stoyanov, Danail, editor, Taylor, Zeike, editor, Ciompi, Francesco, editor, Xu, Yanwu, editor, Martel, Anne, editor, Maier-Hein, Lena, editor, Rajpoot, Nasir, editor, van der Laak, Jeroen, editor, Veta, Mitko, editor, McKenna, Stephen, editor, Snead, David, editor, Trucco, Emanuele, editor, Garvin, Mona K., editor, Chen, Xin Jan, editor, and Bogunovic, Hrvoje, editor

Published
2018
Full Text
View/download PDF

20. Evaluating CHARGE syndrome in congenital hypogonadotropic hypogonadism patients harboring CHD7 variants

Author

Xu, Cheng, Cassatella, Daniele, van der Sloot, Almer M., Quinton, Richard, Hauschild, Michael, De Geyter, Christian, Flück, Christa, Feller, Katrin, Bartholdi, Deborah, Nemeth, Attila, Halperin, Irene, Pekic Djurdjevic, Sandra, Maeder, Philippe, Papadakis, Georgios, Dwyer, Andrew A., Marino, Laura, Favre, Lucie, Pignatelli, Duarte, Niederländer, Nicolas J., Acierno, James, and Pitteloud, Nelly

Published
2018
Full Text
View/download PDF

21. Towards an Automated Segmentation of the Ventro-Intermediate Thalamic Nucleus

Author

Najdenovska, Elena, Tuleasca, Constantin, Jorge, João, Marques, José P., Maeder, Philippe, Thiran, Jean-Philippe, Levivier, Marc, Cuadra, Meritxell Bach, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cardoso, M. Jorge, editor, Arbel, Tal, editor, Luo, Xiongbiao, editor, Wesarg, Stefan, editor, Reichl, Tobias, editor, González Ballester, Miguel Ángel, editor, McLeod, Jonathan, editor, Drechsler, Klaus, editor, Peters, Terry, editor, Erdt, Marius, editor, Mori, Kensaku, editor, Linguraru, Marius George, editor, Uhl, Andreas, editor, Oyarzun Laura, Cristina, editor, and Shekhar, Raj, editor

Published
2017
Full Text
View/download PDF

22. MR Imaging of Adverse Effects and Ocular Growth Decline after Selective Intra-Arterial Chemotherapy for Retinoblastoma.

Author

de Bloeme, Christiaan M., van Elst, Sabien, Galluzzi, Paolo, Jansen, Robin W., de Haan, Joeka, Göricke, Sophia, Moll, Annette C., Bot, Joseph C. J., Munier, Francis L., Beck-Popovic, Maja, Puccinelli, Francesco, Aerts, Isabelle, Hadjistilianou, Theodora, Sirin, Selma, Koob, Mériam, Brisse, Hervé J., Cardoen, Liesbeth, Maeder, Philippe, de Jong, Marcus C., and de Graaf, Pim

Subjects
OPTIC nerve diseases, VISION disorders, EYE, QUALITATIVE research, RESEARCH funding, DISEASE management, MAGNETIC resonance imaging, RETROSPECTIVE studies, QUANTITATIVE research, TREATMENT effectiveness, RETINOBLASTOMA, CANCER chemotherapy, RESEARCH, DEEP learning, COMPARATIVE studies, INFLAMMATION
Abstract

Simple Summary: This study investigates the adverse effects of selective intra-arterial chemotherapy (SIAC) on the eyes and optic nerves of retinoblastoma patients using magnetic resonance imaging (MRI). We aim to understand the post-SIAC changes in orbital and ocular structures and evaluate their impact on eye and optic nerve growth. Experienced radiologists analyzed MR images of retinoblastoma eyes treated with SIAC, comparing them to eyes treated with other eye-saving methods and healthy eyes. Results reveal common adverse effects like inflammation and vascular changes, along with significant ocular growth arrest and optic nerve atrophy in eyes treated with SIAC, especially in children treated ≤ 12 months of age. This study underscores the importance of careful consideration when utilizing SIAC, particularly in young patients, due to its potential negative effects on eye and optic nerve development. This retrospective multicenter study examines therapy-induced orbital and ocular MRI findings in retinoblastoma patients following selective intra-arterial chemotherapy (SIAC) and quantifies the impact of SIAC on ocular and optic nerve growth. Patients were selected based on medical chart review, with inclusion criteria requiring the availability of posttreatment MR imaging encompassing T2-weighted and T1-weighted images (pre- and post-intravenous gadolinium administration). Qualitative features and quantitative measurements were independently scored by experienced radiologists, with deep learning segmentation aiding total eye volume assessment. Eyes were categorized into three groups: eyes receiving SIAC (Rb-SIAC), eyes treated with other eye-saving methods (Rb-control), and healthy eyes. The most prevalent adverse effects post-SIAC were inflammatory and vascular features, with therapy-induced contrast enhancement observed in the intraorbital optic nerve segment in 6% of patients. Quantitative analysis revealed significant growth arrest in Rb-SIAC eyes, particularly when treatment commenced ≤ 12 months of age. Optic nerve atrophy was a significant complication in Rb-SIAC eyes. In conclusion, this study highlights the vascular and inflammatory adverse effects observed post-SIAC in retinoblastoma patients and demonstrates a negative impact on eye and optic nerve growth, particularly in children treated ≤ 12 months of age, providing crucial insights for clinical management and future research. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

30. Correlation of gene expression with magnetic resonance imaging features of retinoblastoma: a multi-center radiogenomics validation study

Author

Jansen, Robin W, Roohollahi, Khashayar, Uner, Ogul E, de Jong, Yvonne, de Bloeme, Christiaan M, Göricke, Sophia, Sirin, Selma, Maeder, Philippe, Galluzzi, Paolo, Brisse, Hervé J, Cardoen, Liesbeth, Castelijns, Jonas A, van der Valk, Paul, Moll, Annette C, Grossniklaus, Hans, Hubbard, G Baker, de Jong, Marcus C, Dorsman, Josephine, de Graaf, Pim, Jansen, Robin W, Roohollahi, Khashayar, Uner, Ogul E, de Jong, Yvonne, de Bloeme, Christiaan M, Göricke, Sophia, Sirin, Selma, Maeder, Philippe, Galluzzi, Paolo, Brisse, Hervé J, Cardoen, Liesbeth, Castelijns, Jonas A, van der Valk, Paul, Moll, Annette C, Grossniklaus, Hans, Hubbard, G Baker, de Jong, Marcus C, Dorsman, Josephine, and de Graaf, Pim

Abstract

OBJECTIVES To validate associations between MRI features and gene expression profiles in retinoblastoma, thereby evaluating the repeatability of radiogenomics in retinoblastoma. METHODS In this retrospective multicenter cohort study, retinoblastoma patients with gene expression data and MRI were included. MRI features (scored blinded for clinical data) and matched genome-wide gene expression data were used to perform radiogenomic analysis. Expression data from each center were first separately processed and analyzed. The end product normalized expression values from different sites were subsequently merged by their Z-score to permit cross-sites validation analysis. The MRI features were non-parametrically correlated with expression of photoreceptorness (radiogenomic analysis), a gene expression signature informing on disease progression. Outcomes were compared to outcomes in a previous described cohort. RESULTS Thirty-six retinoblastoma patients were included, 15 were female (42%), and mean age was 24 (SD 18) months. Similar to the prior evaluation, this validation study showed that low photoreceptorness gene expression was associated with advanced stage imaging features. Validated imaging features associated with low photoreceptorness were multifocality, a tumor encompassing the entire retina or entire globe, and a diffuse growth pattern (all p < 0.05). There were a number of radiogenomic associations that were also not validated. CONCLUSIONS A part of the radiogenomic associations could not be validated, underlining the importance of validation studies. Nevertheless, cross-center validation of imaging features associated with photoreceptorness gene expression highlighted the capability radiogenomics to non-invasively inform on molecular subtypes in retinoblastoma. CLINICAL RELEVANCE STATEMENT Radiogenomics may serve as a surrogate for molecular subtyping based on histopathology material in an era of eye-sparing retinoblastoma treatment strategies. KEY POINTS - Sin

Published
2023

31. MRI Features for Identifying MYCN-amplified RB1 Wild-type Retinoblastoma

Author

Jansen, Robin W; https://orcid.org/0000-0003-0347-1919, de Bloeme, Christiaan M; https://orcid.org/0000-0002-4901-0301, Cardoen, Liesbeth; https://orcid.org/0000-0001-7842-8638, Göricke, Sophia, van Elst, Sabien; https://orcid.org/0000-0003-2784-1988, Jessen, Jaime Lyn, Ramasubramanian, Aparna, Skalet, Alison H, Miller, Audra K; https://orcid.org/0000-0003-2774-6059, Maeder, Philippe; https://orcid.org/0000-0002-2875-4889, Uner, Ogul E; https://orcid.org/0000-0002-8730-6859, Hubbard, G Baker; https://orcid.org/0000-0001-5427-438X, Grossniklaus, Hans, Boldt, H Culver; https://orcid.org/0000-0002-7292-2093, Nichols, Kim E; https://orcid.org/0000-0002-5581-6555, Brennan, Rachel C; https://orcid.org/0000-0002-2090-4395, Sen, Saugata; https://orcid.org/0000-0002-0418-712X, Sirin, Selma; https://orcid.org/0000-0003-4555-0367, Brisse, Hervé J; https://orcid.org/0000-0003-2794-5875, Galluzzi, Paolo; https://orcid.org/0000-0002-7553-5064, Dommering, Charlotte J; https://orcid.org/0000-0001-5565-7526, Castelijns, Jonas A, van der Valk, Paul, Boellaard, Ronald, Dorsman, Josephine, Moll, Annette C; https://orcid.org/0000-0002-9313-8345, de Jong, Marcus C; https://orcid.org/0000-0002-8524-5108, de Graaf, Pim; https://orcid.org/0000-0003-1938-0747, Jansen, Robin W; https://orcid.org/0000-0003-0347-1919, de Bloeme, Christiaan M; https://orcid.org/0000-0002-4901-0301, Cardoen, Liesbeth; https://orcid.org/0000-0001-7842-8638, Göricke, Sophia, van Elst, Sabien; https://orcid.org/0000-0003-2784-1988, Jessen, Jaime Lyn, Ramasubramanian, Aparna, Skalet, Alison H, Miller, Audra K; https://orcid.org/0000-0003-2774-6059, Maeder, Philippe; https://orcid.org/0000-0002-2875-4889, Uner, Ogul E; https://orcid.org/0000-0002-8730-6859, Hubbard, G Baker; https://orcid.org/0000-0001-5427-438X, Grossniklaus, Hans, Boldt, H Culver; https://orcid.org/0000-0002-7292-2093, Nichols, Kim E; https://orcid.org/0000-0002-5581-6555, Brennan, Rachel C; https://orcid.org/0000-0002-2090-4395, Sen, Saugata; https://orcid.org/0000-0002-0418-712X, Sirin, Selma; https://orcid.org/0000-0003-4555-0367, Brisse, Hervé J; https://orcid.org/0000-0003-2794-5875, Galluzzi, Paolo; https://orcid.org/0000-0002-7553-5064, Dommering, Charlotte J; https://orcid.org/0000-0001-5565-7526, Castelijns, Jonas A, van der Valk, Paul, Boellaard, Ronald, Dorsman, Josephine, Moll, Annette C; https://orcid.org/0000-0002-9313-8345, de Jong, Marcus C; https://orcid.org/0000-0002-8524-5108, and de Graaf, Pim; https://orcid.org/0000-0003-1938-0747

Abstract

Background MYCN-amplified RB1 wild-type (MYCN$^{A}$RB1$^{+/+}$) retinoblastoma is a rare but clinically important subtype of retinoblastoma due to its aggressive character and relative resistance to typical therapeutic approaches. Because biopsy is not indicated in retinoblastoma, specific MRI features might be valuable to identify children with this genetic subtype. Purpose To define the MRI phenotype of MYCN$^{A}$RB1$^{+/+}$ retinoblastoma and evaluate the ability of qualitative MRI features to help identify this specific genetic subtype. Materials and Methods In this retrospective, multicenter, case-control study, MRI scans in children with MYCN$^{A}$RB1$^{+/+}$ retinoblastoma and age-matched children with RB1$^{-/-}$ subtype retinoblastoma were included (case-control ratio, 1:4; scans acquired from June 2001 to February 2021; scans collected from May 2018 to October 2021). Patients with histopathologically confirmed unilateral retinoblastoma, genetic testing (RB1/MYCN status), and MRI scans were included. Associations between radiologist-scored imaging features and diagnosis were assessed with the Fisher exact test or Fisher-Freeman-Halton test, and Bonferroni-corrected P values were calculated. Results A total of 110 patients from 10 retinoblastoma referral centers were included: 22 children with MYCN$^{A}$RB1$^{+/+}$ retinoblastoma and 88 control children with RB1$^{-/-}$ retinoblastoma. Children in the MYCN$^{A}$RB1$^{+/+}$ group had a median age of 7.0 months (IQR, 5.0-9.0 months) (13 boys), while children in the RB1$^{-/-}$ group had a median age of 9.0 months (IQR, 4.6-13.4 months) (46 boys). MYCN$^{A}$RB1$^{+/+}$ retinoblastomas were typically peripherally located (in 10 of 17 children; specificity, 97%; P < .001) and exhibited plaque or pleomorphic shape (in 20 of 22 children; specificity, 51%; P = .011) with irregular margins (in 16 of 22 children; specificity, 70%; P = .008) and extensive retina folding with vitreous enclosure (specificity, 94%; P < .0

Published
2023

32. MRI Features for Identifying MYCN-amplified RB1 Wild-type Retinoblastoma

Author

Jansen, Robin W., primary, de Bloeme, Christiaan M., additional, Cardoen, Liesbeth, additional, Göricke, Sophia, additional, van Elst, Sabien, additional, Jessen, Jaime Lyn, additional, Ramasubramanian, Aparna, additional, Skalet, Alison H., additional, Miller, Audra K., additional, Maeder, Philippe, additional, Uner, Ogul E., additional, Hubbard, G. Baker, additional, Grossniklaus, Hans, additional, Boldt, H. Culver, additional, Nichols, Kim E., additional, Brennan, Rachel C., additional, Sen, Saugata, additional, Sirin, Selma, additional, Brisse, Hervé J., additional, Galluzzi, Paolo, additional, Dommering, Charlotte J., additional, Castelijns, Jonas A., additional, van der Valk, Paul, additional, Boellaard, Ronald, additional, Dorsman, Josephine, additional, Moll, Annette C., additional, de Jong, Marcus C., additional, and de Graaf, Pim, additional

Published
2023
Full Text
View/download PDF

43. Cross Validation of Experts Versus Registration Methods for Target Localization in Deep Brain Stimulation

Author

Castro, F. Javier Sánchez, Pollo, Claudio, Meuli, Reto, Maeder, Philippe, Cuadra, Meritxell Bach, Cuisenaire, Olivier, Villemure, Jean-Guy, Thiran, Jean-Philippe, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Duncan, James S., editor, and Gerig, Guido, editor

Published
2005
Full Text
View/download PDF

44. Magnetic Resonance Imaging Can Reliably Differentiate Optic Nerve Inflammation from Tumor Invasion in Retinoblastoma with Orbital Cellulitis

Author

Jansen, Robin W., primary, van der Heide, Sophie, additional, Cardoen, Liesbeth, additional, Sirin, Selma, additional, de Bloeme, Christiaan M., additional, Galluzzi, Paolo, additional, Göricke, Sophia, additional, Brisse, Hervé J., additional, Maeder, Philippe, additional, Sen, Saugata, additional, Biewald, Eva, additional, Castelijns, Jonas A., additional, Moll, Annette C., additional, van der Valk, Paul, additional, de Jong, Marcus C., additional, de Graaf, Pim, additional, and Jansen, Robin W., additional

Published
2022
Full Text
View/download PDF

47. Second cranio-facial malignancies in hereditary retinoblastoma survivors previously treated with radiation therapy: Clinic and radiologic characteristics and survival outcomes

Author

Rodjan, Firazia, Graaf, Pim de, Brisse, Hervé J., Verbeke, Jonathan I.L.M., Sanchez, Esther, Galluzzi, Paolo, Göricke, Sophia, Maeder, Philippe, Aerts, Isabelle, Dendale, Remi, Desjardins, Laurence, de Franscesco, Sonia, Bornfeld, Norbert, Sauerwein, Wolfgang, Popovic, Maja Beck, Knol, Dirk L., Moll, Annette C., and Castelijns, Jonas A.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results