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1. Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients

Author

Belo, Luís, primary, Valente, Maria João, additional, Rocha, Susana, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Lousa, Irina, additional, Bronze-da-Rocha, Elsa, additional, Rocha-Pereira, Petronila, additional, Sameiro-Faria, Maria do, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Miranda, Vasco, additional, Nunes, José Pedro L., additional, and Santos-Silva, Alice, additional

Published
2024
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3. Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients

Author

Belo, Luís, Valente, Maria João, Rocha, Susana, Coimbra, Susana, Catarino, Cristina, Lousa, Irina, Bronze-da-Rocha, Elsa, Rocha-Pereira, Petronila, Sameiro-Faria, Maria do, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Miranda, Vasco, Nunes, José Pedro L., Santos-Silva, Alice, Belo, Luís, Valente, Maria João, Rocha, Susana, Coimbra, Susana, Catarino, Cristina, Lousa, Irina, Bronze-da-Rocha, Elsa, Rocha-Pereira, Petronila, Sameiro-Faria, Maria do, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Miranda, Vasco, Nunes, José Pedro L., and Santos-Silva, Alice

Abstract

Worldwide, the number of elderly individuals receiving chronic hemodialysis is rising. The aim of our study was to evaluate several clinical and analytical biomarkers in chronically dialyzed patients and analyze how they change with age. A cross-sectional study was performed by evaluating 289 end-stage renal disease patients undergoing dialysis. We evaluated the hemogram, adipokines, the lipid profile, and several markers related to inflammation, endothelial function/fibrinolysis, nutrition, iron metabolism, and cardiac and renal fibrosis. Clinical data and dialysis efficacy parameters were obtained from all patients. The relationships between studied biomarkers and age were assessed by a statistical comparison between younger (adults with age < 65 years) and older (age ≥ 65 years) patients and by performing regression analysis. Participants presented a mean age of 68.7 years (±13.6), with 66.8% (n = 193) being classified as older. Compared to younger patients, older patients presented the following: (a) significantly lower values of diastolic blood pressure (DBP) and ultrafiltration volume; (b) lower levels of phosphorus, uric acid, creatinine, and albumin; and (c) higher circulating concentrations of tissue-type plasminogen activator (tPA), D-dimer, interleukin-6, leptin, N-terminal pro B-type natriuretic peptide, and tissue inhibitor of metalloproteinase-1. In the multiple linear regression analysis, DBP values, tPA, phosphorus, and D-dimer levels were independently associated with the age of patients (standardized betas: −0.407, 0.272, −0.230, and 0.197, respectively; p < 0.001 for all), demonstrating relevant changes in biomarkers with increasing age at cardiovascular and nutritional levels. These findings seem to result from crosstalk mechanisms between aging and chronic kidney disease.

Published
2024

4. Impact of TNFRSF1B (rs3397, rs1061624 and rs1061622) and IL6 (rs1800796, rs1800797 and rs1554606) Gene Polymorphisms on Inflammatory Response in Patients with End-Stage Kidney Disease Undergoing Dialysis.

Author

Coimbra, Susana, Rocha, Susana, Catarino, Cristina, Valente, Maria João, Rocha-Pereira, Petronila, Sameiro-Faria, Maria, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Miranda, Vasco, Belo, Luís, Bronze-da-Rocha, Elsa, and Santos-Silva, Alice

Subjects
CHRONIC kidney failure, GENETIC polymorphisms, INTERLEUKIN-6, TUMOR necrosis factors, INFLAMMATION, BLOOD cell count, POLYMORPHISM (Crystallography)
Abstract

We aimed to study the impact of polymorphisms in the genes encoding interleukin-6 (IL6) and tumor necrosis factor receptor-2 (TNFR2), reported to be mortality risk predictors, in patients with end-stage kidney disease (ESKD) undergoing dialysis. TNFRSF1B (rs3397, rs1061624, and rs1061622) and IL6 (rs1800796, rs1800797, and rs1554606) polymorphisms were studied in patients with ESKD and controls; the genotype and allele frequencies and the associations with inflammatory and erythropoiesis markers were determined; deaths were recorded throughout the following two years. The genotype and allele frequencies for the TNFRSF1B rs3397 polymorphism were different in these patients compared to those in the controls and the global and European populations, and patients with the C allele were less common. Patients with the CC genotype for TNFRSF1B rs3397 presented higher hemoglobin and erythrocyte counts and lower TNF-α levels, suggesting a more favorable inflammatory response that seems to be associated with erythropoiesis improvement. Patients with the GG genotype for TNFRSF1B rs1061622 showed lower serum ferritin levels. None of the TNFRSF1B (rs3397, rs1061624, and rs1061622) or IL6 (rs1800796, rs1800797, and rs1554606) polymorphisms had a significant impact on the all-cause mortality rate of Portuguese patients with ESKD. [ABSTRACT FROM AUTHOR]

Published
2024
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7. O Brasil seis meses após a declaração da Covid-19 como pandemia global

Author

Freitas, Carlos Machado de, primary, Barcellos, Christovam, additional, Villela, Daniel Antunes Maciel, additional, Portela, Margareth Crisóstomo, additional, Reis, Lenice Costa, additional, Matta, Gustavo Corrêa, additional, Périssé, André, additional, Leandro, Bianca, additional, Batistella, Carlos Eduardo, additional, Araújo, Fábio, additional, Ângelo, Jussara, additional, Carrijo, Renata de Saldanha da Gama Gracie, additional, Oliveira, Roberta Gondim de, additional, Pontes, Ana Lúcia, additional, Cardoso, Andrey, additional, Santos, Ricardo Ventura, additional, Lima, André Luiz da Silva, additional, Madureira, José Leonídio, additional, and Martins, Mariane, additional

Published
2020
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9. #4713 TUMOR NECROSIS FACTOR RECEPTOR 2 POLYMORPHISM (RS1061622) AND INFLAMMATORY RESPONSE IN END-STAGE RENAL DISEASE PATIENTS UNDER DIALYSIS

Author

Coimbra, Susana, primary, Rocha, Susana, additional, Catarino, Cristina, additional, Valente, Maria João, additional, Rocha-Pereira, Petronila, additional, Faria, Maria Do Sameiro, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João, additional, Miranda, Vasco M P, additional, Bronze-Da-Rocha, Elsa, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2023
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10. The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis

Author

Coimbra, Susana, primary, Catarino, Cristina, additional, Sameiro Faria, Maria, additional, Nunes, José Pedro L., additional, Rocha, Susana, additional, Valente, Maria João, additional, Rocha-Pereira, Petronila, additional, Bronze-da-Rocha, Elsa, additional, Bettencourt, Nuno, additional, Beco, Ana, additional, Marques, Sofia Homem de Melo, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2023
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11. The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis

Author

Coimbra, Susana, Catarino, Cristina, Faria, Maria Sameiro, Nunes, José Pedro L., Rocha, Susana, Valente, Maria João, Rocha-Pereira, Petronila, Bronze-da-Rocha, Elsa, Bettencourt, Nuno, Beco, Ana, Marques, Sofia Homem de Melo, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Miranda, Vasco, Belo, Luís, Santos-Silva, Alice, Coimbra, Susana, Catarino, Cristina, Faria, Maria Sameiro, Nunes, José Pedro L., Rocha, Susana, Valente, Maria João, Rocha-Pereira, Petronila, Bronze-da-Rocha, Elsa, Bettencourt, Nuno, Beco, Ana, Marques, Sofia Homem de Melo, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Miranda, Vasco, Belo, Luís, and Santos-Silva, Alice

Abstract

Left ventricular hypertrophy (LVH) is a common cardiovascular complication in end-stage kidney disease (ESKD) patients. We aimed at studying the association of LVH with adiponectin and leptin levels, cardiovascular stress/injury biomarkers and nutritional status in these patients. We evaluated the LV mass (LVM) and calculated the LVM index (LVMI) in 196 ESKD patients on dialysis; the levels of hemoglobin, calcium, phosphorus, parathyroid hormone, albumin, adiponectin, leptin, N-terminal pro B-type natriuretic peptide (NT-proBNP) and growth differentiation factor (GDF)-15 were analyzed. ESKD patients with LVH (n = 131) presented higher NT-proBNP and GDF-15, lower hemoglobin and, after adjustment for gender, lower leptin levels compared with non-LVH patients. LVH females also showed lower leptin than the non-LVH female group. In the LVH group, LVMI presented a negative correlation with leptin and a positive correlation with NT-proBNP. Leptin emerged as an independent determinant of LVMI in both groups, and NT-proBNP in the LVH group. Low hemoglobin and leptin and increased calcium, NT-proBNP and dialysis vintage are associated with an increased risk of developing LVH. In ESKD patients on dialysis, LVH is associated with lower leptin values (especially in women), which are negatively correlated with LVMI, and with higher levels of biomarkers of myocardial stress/injury. Leptin and NT-proBNP appear as independent determinants of LVMI; dialysis vintage, hemoglobin, calcium, NT-proBNP and leptin emerged as predicting markers for LVH development. Further studies are needed to better understand the role of leptin in LVH in ESKD patients.

Published
2023

12. Corporate governance and corporate tax management: a bibliometric study

Author

Madureira, José and Carvalho, Carla

Subjects
Tax planning, Tax avoidance, Corporate governance, Board, Ownership structure
Abstract

The main objective of this work is to analyze, through a bibliometric study, the evolution and dynamics of scientific production on the relationship between corporate governance and tax management. We base our analysis on 322 articles from Scopus and ISI Web of Science published between 1998 and 2021. The difficulty of accessing confidential information means that most studies focus on tax planning and tax avoidance rather than tax evasion practices. Thus, tax avoidance is the most used expression to refer to tax management and, excluding the general expression corporate governance, the most used corporate governance mechanisms in the keywords are CEO, ownership structure, and board. However, political connections and gender are two expressions that have attracted more interest from researchers in the last three years. Most studies and the most influential are by authors affiliated in the USA, China, and Australia, and more research still needs to be carried out on samples of European companies. In addition, most studies use metrics to quantify tax management applied to the reality of US companies with a tax system different from the European one. This study contributes to the knowledge about the most studied tax management practices and the most related governance mechanisms, allowing the identification of clues for future research. published

Published
2023

13. Corporate Governance and Corporate Tax Management

Author

Madureira, José António and Carvalho, Carla

Abstract

The main objective of this work is to analyze, through a bibliometric study, the evolution and dynamics of scientific production on the relationship between corporate governance and tax management. We base our analysis on 322 articles from Scopus and ISI Web of Science published between 1998 and 2021. The difficulty of accessing confidential information means that most studies focus on tax planning and tax avoidance rather than tax evasion practices. Thus, tax avoidance is the most used expression to refer to tax management and, excluding the general expression corporate governance, the most used corporate governance mechanisms in the keywords are CEO, ownership structure, and board. However, political connections and gender are two expressions that have attracted more interest from researchers in the last three years. Most studies and the most influential are by authors affiliated in the USA, China, and Australia, and more research still needs to be carried out on samples of European companies. In addition, most studies use metrics to quantify tax management applied to the reality of US companies with a tax system different from the European one. This study contributes to the knowledge about the most studied tax management practices and the most related governance mechanisms, allowing the identification of clues for future research., International Journal of Business Innovation, Volume 2 Issue 1 (2023)

Published
2023

15. A primeira temporada do Canal Hop Musical (2021-2022): produção e divulgação de conteúdo acadêmico audiovisual de Arte, Cultura e Educação

Author

Madureira, José Rafael and Arrais Padilha, Ísis

Abstract

Com o advento das mídias sociais e das plataformas de streaming, a cultura visual-midiática alcançou uma dimensão inimaginável e se imbricou ainda mais aos interesses econômicos da indústria cultural. Essa nova cultura de imagens e sons se fortaleceu com a pandemia do coronavírus e obrigou os acadêmicos (professores e pesquisadores) a entrar no jogo e aprender, a toque de caixa, procedimentos técnicos de produção de eventos virtuais (aulas, conferências, seminários). Diante desse quadro e com a suspensão das atividades extensionistas presenciais, propusemos junto à Pró-Reitoria de Extensão e Cultura da Universidade Federal dos Vales do Jequitinhonha e Mucuri o Canal Hop Musical, um projeto de produção e divulgação de conteúdos acadêmicos de Arte, Cultura e Educação (entrevistas, documentários, podcasts, ensaios visuais), contando com a parceria de artistas e pesquisadores de todo Brasil e exterior.

Published
2023

18. Sobre la poética del ritmo en las artes (y en la vida)

Author

Madureira, José Rafael and Padilha, Ísis Arrais

Subjects
Science, Pedagogy, Rhythm, Filosofia, Corporeidad, Embodiment, Philosophy, Ciencias, Ritmo, Filosofía, Pedagogía, Arte, Ciência, Pedagogia, Art, Corporalidade
Abstract

Review of the book Ritmicidades, cuerpos en JIRA [2015-2019], a collection organized by Carla Fonseca in partnership with the Department of Dramatic Arts of the Universidad Nacional de las Artes (UNA) that brought together the contributions of 22 authors (artists and academics) from different countries that were previously presented during the five editions of the Jornadas Internacionales el Ritmo en las Artes – JIRA (Buenos Aires, 2015-2019). The book was organized with the purpose of putting into theoretical and practical debate the experience of rhythm in various fields of knowledge: epistemology, neuroscience, arts, languages, semiology, psychoanalysis and pedagogy. Ritmicidades is the eloquent record of what was presented, experienced and discussed during all JIRA editions. Reseña del libro Ritmicidades, cuerpos en JIRA [2015-2019], colección organizada por Carla Fonseca en alianza con el Departamento de Artes Dramaticas de la Universidad Nacional de las Artes (UNA) que reunió los aportes de 22 autores (artistas y académicos) de diferentes países que fueron presentados anteriormente durante las cinco ediciones de las Jornadas Internacionales el Ritmo en las Artes - JIRA (Buenos Aires, 2015-2019). El libro fue organizado con el propósito de poner en debate teórico-práctico la experiencia del ritmo en diversos campos del conocimiento: epistemología, neurociencia, artes, lenguajes, semiología, psicoanálisis y pedagogía. Rhythmicities es el registro elocuente de lo que se presentó, experimentó y discutió durante todas las ediciones de JIRA. Resenha do livro Ritmicidades, cuerpos en JIRA [2015-2019], uma coletânea organizada por Carla Fonseca em parceria com o Departamento de Artes Dramáticas da Universidad Nacional de las Artes (UNA) que reuniu as contribuições de 22 autores de diversos países que foram anteriormente apresentadas durante as cinco edições das Jornadas Internacionales el Ritmo en las Artes – JIRA (Buenos Aires, 2015-2019). O livro foi organizado com o propósito de colocar em discussão a experiência do ritmo em diversos campos do conhecimento: epistemologia, neurociências, artes, linguagens, semiologia, psicanálise e pedagogia. Ritmicidades é o eloquente registro do que foi apresentado, vivenciado e discutido durante as todas as edições das JIRA.

Published
2021

22. MO810INTERLEUKIN-6 (-174G/C) POLYMORPHISM, RS1800795, IN ESRD PATIENTS' OUTCOME*

Author

Rocha, Susana, primary, Valente, Maria João, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Faria, Maria do Sameiro, additional, Miranda, Vasco M P, additional, Belo, Luís, additional, Santos-Silva, Alice, additional, and Bronze-da-Rocha, Elsa, additional

Published
2021
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23. MO735INTERPLAY BETWEEN GDF-15 AND LEFT VENTRICULAR HYPERTROPHY IN END-STAGE RENAL DISEASE PATIENTS ON DIALYSIS

Author

Coimbra, Susana, primary, Catarino, Cristina, additional, Faria, Maria do Sameiro, additional, Lopes Nunes, José Pedro, additional, Rocha, Susana, additional, Valente, Maria João, additional, Rocha-Pereira, Petronila, additional, Bronze-da-Rocha, Elsa, additional, Bettencourt, Nuno, additional, Beco, Ana, additional, Homem Melo Marques, Sofia, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Miranda, Vasco M P, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2021
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24. Interleukin 6 (rs1800795) and Pentraxin 3 (rs2305619) Polymorphisms - Association with Inflammation and All-Cause Mortality in End-stage-renal Disease Patients on Dialysis

Author

Rocha, Susana, primary, Valente, Maria João, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Sameiro-Faria, Maria, additional, Miranda, Vasco, additional, Belo, Luís, additional, Santos-Silva, Alice, additional, and Bronze-da-Rocha, Elsa, additional

Published
2021
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25. Radar COVID-19, Favelas

Author

Lima, André, Amadeus, Djefferson, Araújo, Fábio, Madureira, José Leonídio, Martins, Mariane, Medeiros, Day, Dutra, Renata, Gondim, Roberta, and Batistella, Carlos Eduardo

Subjects
Favela, Observatório COVID-19, Racismo estrutural, Dados abertos, Dados oficiais, Covid-19
Abstract

Radar COVID-19, Favelas é um informativo produzido no âmbito da Sala de Situação Covid-19 nas Favelas do Rio de Janeiro, vinculada ao Observatório COVID-19 da Fiocruz. Estruturado com base no monitoramento ativo (vigilância de rumores) de fontes não oficiais – mídias, redes sociais e contato direto com moradores, coletivos, movimentos sociais, instituições e articuladores locais – busca sistematizar, analisar e disseminar informações sobre a situação de saúde nos territórios selecionados, visando promover a visibilidade das diversas situações de vulnerabilidade e antecipar as iniciativas de enfrentamento da pandemia. Os relatos são coletados por meio da constituição de uma rede de interlocutores, valorizando a produção compartilhada de conhecimento, o acesso e a participação ativa de moradores de favelas e de seus movimentos sociais. Desculpe - Não esqueça que (embora esteja especificado na descrição como 4.0 ) a atribuição de licença no site da Fiocruz é * Atribuição-Não Comercial 3.0 Brasil (CC BY-NC 3.0 BR) This is a human-readable summary of (and not a substitute for) the license. Exoneração de Responsabilidade. Você tem o direito de: Compartilhar — copiar e redistribuir o material em qualquer suporte ou formato Adaptar — remixar, transformar, e criar a partir do material O licenciante não pode revogar estes direitos desde que você respeite os termos da licença., Buscar no próprio site da Fiocruz. https://portal.fiocruz.br/busca?search_api_views_fulltext=radar A atribuição de licença no site da Fiocruz é * Atribuição-Não Comercial 3.0 Brasil (CC BY-NC 3.0 BR)

Published
2020
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26. Mais dança na escola: apreciação estética e formação

Author

Madureira, José Rafael, de Souza, Mônica Freitas Lucinda, Pereira, Daniel Gonçalves, and Murta, Flor

Abstract

A dança está presente na vida das pessoas desde tempos remotos. Ela nasce da necessidade humana de conexão e harmonização com as vozes da natureza. Como linguagem e arte, já esteve intimamente associada à rituais sagrados, casamentos, funerais, especialmente para os povos orientais. No contexto da civilização moderna europeia, a dança se esvaziou dessa dimensão transcendental. A virada do século XIX para o século XX foi cenário de grandes revoluções para a dança, que recuperou as suas forças generativas, apresentando-se como uma arte independente, como linguagem cênica transnacional. Rudolf Laban, foi um dos protagonistas dessa revolução. Ao pensar a dança como Coreologia (RENGEL, 2014), Laban revelou uma genialidade sem precedentes. Assim, diante de todo esse potencial cultural e formativo, acreditamos que a dança deveria estar na escola. Com base nessa concepção, escrevemos o projeto Processo Criativo em Dança, contemplado por três vezes pelo Programa de Bolsas de Apoio à Cultura e à Arte (Procarte), um edital criado pela Pró-Reitoria de Extensão e Cultura (PROEXC) da Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM) com o propósito de buscar estratégias para ampliar o acesso da comunidade acadêmica às diversas expressões culturais e artísticas.

Published
2020

30. Cell-free DNA as a marker for the outcome of end-stage renal disease patients on haemodialysis

Author

Coimbra, Susana, primary, Rocha, Susana, additional, Nascimento, Henrique, additional, Valente, Maria João, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Sameiro-Faria, Maria, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Miranda, Vasco, additional, Belo, Luís, additional, Bronze-da-Rocha, Elsa, additional, and Santos-Silva, Alice, additional

Published
2020
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31. P1531DIURETIC USE IN HEMODIALYSIS PATIENTS: BENEFIC ASSOCIATION WITH RESIDUAL RENAL FUNCTION AND ALL-CAUSE MORTALITY

Author

Faria, Maria do Sameiro, primary, Valente, Maria João, primary, Rocha, Susana, primary, Coimbra, Susana, primary, Catarino, Cristina, primary, Rocha-Pereira, Petronila, primary, Bronze-da-Rocha, Elsa, primary, Oliveira, José Gerardo, primary, Madureira, José, primary, Fernandes, João Carlos, primary, Miranda, Vasco M P, primary, Belo, Luís, primary, and Santos-Silva, Alice, primary

Published
2020
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32. P1570INTERLEUKIN-6 (RS1800795) AND PENTRAXIN 3 (RS2305619) GENETIC POLYMORPHISMS AND THEIR RELATION WITH INFLAMMATION AND ALL-CAUSE MORTALITY IN ESRD PATIENTS ON DIALYSIS

Author

Rocha, Susana, primary, Valente, Maria João, primary, Coimbra, Susana, primary, Catarino, Cristina, primary, Rocha-Pereira, Petronila, primary, Faria, Maria do Sameiro, primary, Oliveira, José Gerardo, primary, Madureira, José, primary, Fernandes, João Carlos, primary, Miranda, Vasco M P, primary, Belo, Luís, primary, Santos-Silva, Alice, primary, and Bronze-da-Rocha, Elsa, primary

Published
2020
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33. P1263ASSOCIATION OF LEFT VENTRICULAR HYPERTROPHY AND ADIPOCYTOKINES IN PATIENTS ON DIALYSIS

Author

Catarino, Cristina, primary, Faria, Maria do Sameiro, primary, Lopes Nunes, José Pedro, primary, Rocha, Susana, primary, Valente, Maria João, primary, Coimbra, Susana, primary, Rocha-Pereira, Petronila, primary, Bronze-da-Rocha, Elsa, primary, Bettencourt, Nuno, primary, Beco, Ana, primary, Homem Melo Marques, Sofia, primary, Oliveira, José Gerardo, primary, Madureira, José, primary, Miranda, Vasco M P, primary, Belo, Luís, primary, and Santos-Silva, Alice, primary

Published
2020
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34. P1581IMPACT OF ACHIEVING LDL CHOLESTEROL LOWER THAN 100 MG/DL WITH STATINS, ON LIPID PROFILE AND INFLAMMATION IN END-STAGE RENAL DISEASE PATIENTS

Author

Coimbra, Susana, primary, Reis, Flávio, primary, Nunes, Sara, primary, D. Viana, Sofia, primary, Valente, Maria João, primary, Rocha, Susana, primary, Catarino, Cristina, primary, Rocha-Pereira, Petronila, primary, Bronze-da-Rocha, Elsa, primary, Oliveira, José Gerardo, primary, Madureira, José, primary, Fernandes, João Carlos, primary, Faria, Maria do Sameiro, primary, Miranda, Vasco M P, primary, Belo, Luís, primary, and Santos-Silva, Alice, primary

Published
2020
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36. Effects of statins therapy on LDL subfractions and inflammation in end-stage renal disease patients on dialysis

Author

Coimbra, Susana, Reis, Flávio, Nunes, Sara, Viana, Sofia, Valente, Maria João, Rocha, Susana, Catarino, Cristina, Rocha-Pereira, Petronila, Bronze-da-Rocha, Elsa, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Do Sameiro-Faria, Maria, Miranda, Vasco, Belo, Luís, and Santos-Silva, Alice

Subjects
Inflammation, Inflamação, Falência renal crónica, Statins, Lipoproteínas LDL, Inibidores de Hidroximetilglutaril-CoA Redutases, End stage renal disease, LDL
Abstract

Submitted by Sofia Andreia Viana (sofia_viana@estescoimbra.pt) on 2020-02-17T22:23:44Z No. of bitstreams: 1 Statins.pdf: 97389 bytes, checksum: 0020efe1b8824cd2259d7d9143cf00f0 (MD5) Approved for entry into archive by Anabela Henriques (ahenriques@estescoimbra.pt) on 2020-04-17T19:25:56Z (GMT) No. of bitstreams: 1 Statins.pdf: 97389 bytes, checksum: 0020efe1b8824cd2259d7d9143cf00f0 (MD5) Made available in DSpace on 2020-04-17T19:25:56Z (GMT). No. of bitstreams: 1 Statins.pdf: 97389 bytes, checksum: 0020efe1b8824cd2259d7d9143cf00f0 (MD5) Previous issue date: 2019 info:eu-repo/semantics/publishedVersion

Published
2019

37. Long Pentraxin 3 as a Broader Biomarker for Multiple Risk Factors in End-Stage Renal Disease: Association with All-Cause Mortality

Author

Valente, Maria João, primary, Rocha, Susana, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Bronze-da-Rocha, Elsa, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, do Sameiro-Faria, Maria, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2019
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38. SP666MACHINE LEARNING IN PREDICTION OF VULNERABLE OR RESILIENT END-STAGE RENAL DISEASE PATIENTS

Author

Pedroso, João Pedro, primary, Valente, Maria João, additional, Rocha, Susana, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Bronze-Da-Rocha, Elsa, additional, Carvalho, Márcia, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Do Sameiro-Faria, Maria, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2019
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39. FP725PENTRAXIN 3 IN END-STAGE RENAL DISEASE: MULTIPLE RISK BIOMARKER AND PREDICTOR OF ALL-CAUSE MORTALITY

Author

Valente, Maria João, primary, Rocha, Susana, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Bronze-Da-Rocha, Elsa, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Do Sameiro-Faria, Maria, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2019
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40. FP730EFFECTS OF STATINS THERAPY ON LDL SUBFRACTIONS AND INFLAMMATION, IN END-STAGE RENAL DISEASE PATIENTS ON DIALYSIS

Author

Coimbra, Susana, primary, Reis, Flávio, additional, Nunes, Sara, additional, Viana, Sofia, additional, Valente, Maria João, additional, Rocha, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Bronze-Da-Rocha, Elsa, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Do Sameiro-Faria, Maria, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2019
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41. SP674IN DIALYSIS PATIENTS FUROSEMIDE THERAPY IS FAVORABLY RELATED WITH INFLAMMATORY RESPONSE, FIBRINOLYSIS, AND BIOMARKERS OF RESIDUAL RENAL FUNCTION

Author

Do Sameiro-Faria, Maria, primary, Rocha, Susana, additional, Ribeiro, Sandra, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Valente, Maria João, additional, Rocha-Pereira, Petronila, additional, Bronze-Da-Rocha, Elsa, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2019
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42. SP637INFLAMMATION AND CELL-FREE DNA AS BIOMARKERS FOR THE OUTCOME OF END STAGE RENAL DISEASE PATIENTS

Author

Rocha, Susana, primary, Nascimento, Henrique, additional, Valente, Maria João, additional, Coimbra, Susana, additional, Bronze-Da-Rocha, Elsa, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Do Sameiro-Faria, Maria, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2019
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44. The Protective Role of Adiponectin for Lipoproteins in End-Stage Renal Disease Patients: Relationship with Diabetes and Body Mass Index

Author

Coimbra, Susana, primary, Reis, Flávio, additional, Nunes, Sara, additional, Viana, Sofia, additional, Valente, Maria João, additional, Rocha, Susana, additional, Catarino, Cristina, additional, Rocha-Pereira, Petronila, additional, Bronze-da-Rocha, Elsa, additional, Sameiro-Faria, Maria, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2019
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46. Hepcidin and diabetes are independently related with soluble transferrin receptor levels in chronic dialysis patients

Author

Belo, Luís, primary, Rocha, Susana, additional, Valente, Maria João, additional, Coimbra, Susana, additional, Catarino, Cristina, additional, Bronze-da-Rocha, Elsa, additional, Rocha-Pereira, Petronila, additional, do Sameiro-Faria, Maria, additional, Oliveira, José Gerardo, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Miranda, Vasco, additional, and Santos-Silva, Alice, additional

Published
2019
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48. Cell-free DNA as a marker for the outcome of end-stage renal disease patients on haemodialysis.

Author

Coimbra, Susana, Rocha, Susana, Nascimento, Henrique, Valente, Maria João, Catarino, Cristina, Rocha-Pereira, Petronila, Sameiro-Faria, Maria, Oliveira, José Gerardo, Madureira, José, Fernandes, João Carlos, Miranda, Vasco, Belo, Luís, Bronze-da-Rocha, Elsa, and Santos-Silva, Alice

Subjects
CHRONIC kidney failure, HEMODIALYSIS patients, GENETIC markers, DNA damage, OXIDATIVE stress
Abstract

Background DNA damage and inflammation are common in end-stage renal disease (ESRD). Our aim was to evaluate the levels of circulating cell-free DNA (cfDNA) and the relationship with inflammation, anaemia, oxidative stress and haemostatic disturbances in ESRD patients on dialysis. By performing a 1-year follow-up study, we also aimed to evaluate the predictive value of cfDNA for the outcome of ESRD patients. Methods A total of 289 ESRD patients on dialysis were enrolled in the study: we evaluated cfDNA, haemogram, serum iron, hepcidin, inflammatory and oxidative stress markers, and haemostasis. Events and causes of deaths were recorded throughout the follow-up period. Results ESRD patients, as compared with controls, presented significantly higher levels of cfDNA, hepcidin, and inflammatory and oxidative stress markers, and significantly lower values of iron and anaemia-related haemogram parameters. The all-cause mortality rate was 9.7%; compared with alive patients, deceased patients (n  =   28) were older and presented significantly higher values of inflammatory markers and of cfDNA, which was almost 2-fold higher. Furthermore, cfDNA was the best predictor of all-cause mortality and cardiovascular mortality in ESRD patients, in both unadjusted and adjusted models for basic confounding factors in dialysis. Conclusions Our data show cfDNA to be a valuable predictive marker of prognosis in ESRD patients on dialysis treatment; high levels of cfDNA were associated with a poor outcome. [ABSTRACT FROM AUTHOR]

Published
2021
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49. SP348ASSOCIATION OF NT-PRO-BNP WITH ANEMIA, INFLAMMATION AND KIDNEY FUNCTION IN PORTUGUESE DIALYSIS PATIENTS

Author

Catarino, Cristina, primary, Rocha, Susana, additional, Coimbra, Susana, additional, Amorim, Célia, additional, Valente, Maria João, additional, Rocha-Pereira, Petronila, additional, Bronze-da-Rocha, Elsa, additional, Gerardo Oliveira, José, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Faria, Maria do Sameiro, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2018
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50. SP665PENTRAXIN 3 VERSUS GROWTH DIFFERENTIATION FACTOR-15: ASSOCIATION WITH INFLAMMATION, IRON HOMEOSTASIS AND ERYTHROPOIESIS IN END-STAGE RENAL DISEASE PATIENTS

Author

Valente, Maria João, primary, Rocha, Susana, additional, Catarino, Cristina, additional, Coimbra, Susana, additional, Rocha-Pereira, Petronila, additional, Bronze-da-Rocha, Elsa, additional, Gerardo Oliveira, José, additional, Madureira, José, additional, Fernandes, João Carlos, additional, Faria, Maria do Sameiro, additional, Miranda, Vasco, additional, Belo, Luís, additional, and Santos-Silva, Alice, additional

Published
2018
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