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4. Development of antibody levels and subsequent decline in individuals with vaccine induced and hybrid immunity to SARS-CoV-2

Author

Reekie, Joanne, Stovring, Henrik, Nielsen, Henrik, Johansen, Isik S., Benfield, Thomas, Wiese, Lothar, Stærke, Nina Breinholt, Iversen, Kasper, Mustafa, Ahmed Basim, Petersen, Kristine Toft, Juhl, Maria Ruwald, Knudsen, Lene Surland, Iversen, Mette Brouw, Andersen, Sidsel Dahl, Larsen, Fredrikke Dam, Baerends, Eva Anna Marianne, Lindvig, Susan Olaf, Rasmussen, Line Dahlerup, Madsen, Lone Wulff, Bannister, Wendy, Jensen, Tomas Oestergaard, Dietz, Lisa Loksø, Ostrowski, Sisse Rye, Østergaard, Lars, Tolstrup, Martin, Lundgren, Jens D., and Søgaard, Ole Schmeltz

Published
2024
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9. Impact of age and comorbidities on SARS-CoV-2 vaccine-induced T cell immunity

Author

Dietz, Lisa Loksø, Juhl, Anna Karina, Søgaard, Ole Schmeltz, Reekie, Joanne, Nielsen, Henrik, Johansen, Isik Somuncu, Benfield, Thomas, Wiese, Lothar, Stærke, Nina Breinholt, Jensen, Tomas Østergaard, Jakobsen, Stine Finne, Olesen, Rikke, Iversen, Kasper, Fogh, Kamille, Bodilsen, Jacob, Petersen, Kristine Toft, Larsen, Lykke, Madsen, Lone Wulff, Lindvig, Susan Olaf, Holden, Inge Kristine, Raben, Dorthe, Andersen, Sidsel Dahl, Hvidt, Astrid Korning, Andreasen, Signe Rode, Baerends, Eva Anna Marianne, Lundgren, Jens, Østergaard, Lars, and Tolstrup, Martin

Published
2023
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11. SARS-CoV-2 vaccine-induced antibodies protect against Omicron breakthrough infection

Author

Lundgren, J., Østergaard, L., Benfield, T., Krohn-Dehli, L., Petersen, D.K., Fogh, K., Højmark, E., Iversen, K.K., Bek, P., Klastrup, V., Larsen, F., Rasmussen, S.H., Schleimann, M.H., Schieber, S., Stærke, N.B., Søndergaard, A., Tarp, B., Tousgaard, M., Yehdego, Y., Bodilsen, J., Nielsen, H., Petersen, K.T., Ruwald, M., Thisted, R.K., Caspersen, S.F., Iversen, M., Knudsen, L.S., Meyerhoff, J.L., Sander, L.G., Wiese, L., Abildgaard, C., Holden, I.K., Johansen, N.E., Johansen, I.S., Larsen, L., Lindvig, S.O., Madsen, L.W., Øvrehus, A., Kruse, N.A., Lomholdt, H., Krause, T.G., Valentiner-Branth, P., Søborg, B., Fischer, T.K., Erikstrup, C., Ostrowski, S.R., Tolstrup, M., Søgaard, O.S., Raben, D., Jylling, E., Hougaard, D., Andersen, S.D., Lykkegaard, K., Andreasen, S.R., Baerends, E., Dietz, L.L., Hvidt, A.K., Juhl, A.K., Olesen, R., Andersen, K.K., Bannister, W., Bjernved, C., Elsing, T.W., Esmann, F.V., Ghafari, M.A., Gravholdt, E., Jakobsen, S.F., Jakobsen, M.L., Jensen, C.M., Jensen, T.Ø., Kristensen, D., Kumar, L.R., Matthews, C., Normand, N., Olsson, C., Reekie, J., Traytel, A., Weide, T., Hvas, A.M., Støvring, H., Baerends, Eva A.M., Hvidt, Astrid K., Reekie, Joanne, Søgaard, Ole S., Stærke, Nina B., Raben, Dorthe, Nielsen, Henrik, Petersen, Kristine T., Juhl, Maria R., Johansen, Isik S., Lindvig, Susan O., Madsen, Lone W., Wiese, Lothar, Knudsen, Lene S., Iversen, Mette B., Benfield, Thomas, Iversen, Kasper K., Andersen, Sidsel D., Juhl, Anna K., Dietz, Lisa L., Andreasen, Signe R., Fischer, Thea K., Erikstrup, Christian, Valentiner-Branth, Palle, Lundgren, Jens, Østergaard, Lars, and Tolstrup, Martin

Published
2023
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13. Characteristics associated with serological COVID-19 vaccine response and durability in an older population with significant comorbidity: the Danish Nationwide ENFORCE Study

Author

Søgaard, Ole Schmeltz, Reekie, Joanne, Johansen, Isik Somuncu, Nielsen, Henrik, Benfield, Thomas, Wiese, Lothar, Stærke, Nina Breinholt, Iversen, Kasper, Fogh, Kamille, Bodilsen, Jacob, Iversen, Mette, Knudsen, Lene Surland, Klastrup, Vibeke, Larsen, Fredrikke Dam, Andersen, Sidsel Dahl, Hvidt, Astrid Korning, Andreasen, Signe Rode, Madsen, Lone Wulff, Lindvig, Susan Olaf, Øvrehus, Anne, Ostrowski, Sisse Rye, Abildgaard, Christiane, Matthews, Charlotte, Jensen, Tomas O., Raben, Dorthe, Erikstrup, Christian, Fischer, Thea K., Tolstrup, Martin, Østergaard, Lars, and Lundgren, Jens

Published
2022
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14. Omicron BA.5 Neutralization among Vaccine-Boosted Persons with Prior Omicron BA.1/BA.2 Infections

Author

Pedersen, Rune M., Bang, Line L., Tornby, Ditte S., Madsen, Lone W., Holm, Dorte K., Sydenham, Thomas V., Johansen, Isik S., Jensen, Thoger G., Justesen, Ulrik S., and Andersen, Thomas E.

Subjects
Health
Abstract

The SARS-CoV-2 Omicron variant has dominated the COVID-19 pandemic since late 2021, bringing [greater than or equal to]3 waves of increasingly immunity-evasive Omicron subvariants. An early wave of the Omicron [...]

Published
2022

15. Levels of SARS-CoV-2 antibodies among fully vaccinated individuals with Delta or Omicron variant breakthrough infections

Author

Stærke, Nina Breinholt, Reekie, Joanne, Nielsen, Henrik, Benfield, Thomas, Wiese, Lothar, Knudsen, Lene Surland, Iversen, Mette Brouw, Iversen, Kasper, Fogh, Kamille, Bodilsen, Jacob, Juhl, Maria Ruwald, Lindvig, Susan Olaf, Øvrehus, Anne, Madsen, Lone Wulff, Klastrup, Vibeke, Andersen, Sidsel Dahl, Juhl, Anna Karina, Andreasen, Signe Rode, Ostrowski, Sisse Rye, Erikstrup, Christian, Fischer, Thea K., Tolstrup, Martin, Østergaard, Lars, Johansen, Isik Somuncu, Lundgren, Jens, and Søgaard, Ole Schmeltz

Published
2022
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18. Longitudinal evaluation of SARS-CoV-2 T cell immunity over 2 years following vaccination and infection

Author

Juhl, Anna Karina, primary, Loksø Dietz, Lisa, additional, Schmeltz Søgaard, Ole, additional, Reekie, Joanne, additional, Nielsen, Henrik, additional, Somuncu Johansen, Isik, additional, Benfield, Thomas, additional, Wiese, Lothar, additional, Breinholt Stærke, Nina, additional, Østergaard Jensen, Tomas, additional, Olesen, Rikke, additional, Iversen, Kasper, additional, Fogh, Kamille, additional, Bodilsen, Jacob, additional, Wulff Madsen, Lone, additional, Olaf Lindvig, Susan, additional, Raben, Dorthe, additional, Dahl Andersen, Sidsel, additional, Korning Hvidt, Astrid, additional, Rode Andreasen, Signe, additional, Baerends, Eva Anna Marianne, additional, Lundgren, Jens, additional, Østergaard, Lars, additional, and Tolstrup, Martin, additional

Published
2024
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19. Sperm Donation

Author

Koustas, George, Larsen, Peter, Burke, Corey, Madsen, Lone Bruhn, Allahbadia, Gautam Nand, editor, Ata, Baris, editor, Lindheim, Steven R., editor, Woodward, Bryan J., editor, and Bhagavath, Bala, editor

Published
2020
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22. The LIVER CARE trial — screening for liver disease in individuals attending treatment for alcohol use disorder:a randomized controlled feasibility trial

Author

Jepsen, Peter, von Wowern, Natasja, Madsen, Lone Galmstrup, Klausen, Mette Kruse, Düring, Signe, Benthien, Kirstine Skov, Winther-Jensen, Matilde, Petersen, Janne, Askgaard, Gro, Jepsen, Peter, von Wowern, Natasja, Madsen, Lone Galmstrup, Klausen, Mette Kruse, Düring, Signe, Benthien, Kirstine Skov, Winther-Jensen, Matilde, Petersen, Janne, and Askgaard, Gro

Abstract

Background Alcohol-related liver disease is a preventable disease with high mortality. If individuals with alcohol-related liver disease were to be diagnosed earlier by screening and they reduced their alcohol consumption, lives lost to alcohol-related liver disease might be saved. A liver stiffness measurement (FibroScan©) is a key tool to screen for alcohol-related liver disease in asymptomatic individuals. No randomized controlled trials have been conducted to test if screening for liver disease reduces alcohol consumption in individuals with alcohol use disorders, in addition to what can be obtained by motivational interventions. We aimed to assess the feasibility of a randomized controlled trial of a screening for liver disease on the prevalence of alcohol abstinence or light consumption after 6 months in individuals attending outpatient treatment for alcohol use disorder. Methods We used an interdisciplinary approach to develop the format of the randomized controlled trial. Individuals were recruited from one outpatient treatment facility for alcohol use disorders. Study participants were randomized 1:1 to receive a) a liver stiffness measurement in addition to usual care (intervention) or b) usual care (control). Follow-up on alcohol consumption was assessed by telephone interview after 6 months and corroborated by data from records from public hospitals and the alcohol treatment facility. Feasibility was assessed by probabilities of recruitment, retention, and completion and estimated by the exact binominal test, with success defined as > 50% participation for each endpoint. The study design was evaluated at interdisciplinary meetings with staff and researchers from the outpatient alcohol treatment facility and the hospital clinic. Results Forty of 57 invited individuals agreed to participate in the study (recruitment = 70% (95% CI: 57–82)); 19 of 20 participants randomized to the intervention showed up for the screening (ret, Background: Alcohol-related liver disease is a preventable disease with high mortality. If individuals with alcohol-related liver disease were to be diagnosed earlier by screening and they reduced their alcohol consumption, lives lost to alcohol-related liver disease might be saved. A liver stiffness measurement (FibroScan

Published
2024

23. Longitudinal Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Immunity Over 2 Years Following Vaccination and Infection.

Author

Juhl, Anna Karina, Dietz, Lisa Loksø, Søgaard, Ole Schmeltz, Reekie, Joanne, Nielsen, Henrik, Johansen, Isik Somuncu, Benfield, Thomas, Wiese, Lothar, Stærke, Nina Breinholt, Jensen, Tomas Østergaard, Olesen, Rikke, Iversen, Kasper, Fogh, Kamille, Bodilsen, Jacob, Madsen, Lone Wulff, Lindvig, Susan Olaf, Raben, Dorthe, Andersen, Sidsel Dahl, Hvidt, Astrid Korning, and Andreasen, Signe Rode

Subjects
SARS-CoV-2, HUMORAL immunity, BOOSTER vaccines, HERD immunity, COMBINED vaccines
Abstract

Background Within a year of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, vaccines inducing a robust humoral and cellular immune response were implemented worldwide. However, emergence of novel variants and waning vaccine-induced immunity led to implementation of additional vaccine boosters. Methods This prospective study evaluated the temporal profile of cellular and serological responses in a cohort of 639 SARS-CoV-2–vaccinated participants, of whom a large proportion experienced a SARS-CoV-2 infection. All participants were infection naïve at the time of their first vaccine dose. Proportions of SARS-CoV-2 spike–specific T cells were determined after each vaccine dose using the activation-induced marker assay, while levels of circulating SARS-CoV-2 antibodies were determined by the Meso Scale serology assay. Results We found a significant increase in SARS-CoV-2 spike–specific CD4+ and CD8+ T-cell responses following the third dose of a SARS-CoV-2 messenger RNA vaccine as well as enhanced CD8+ T-cell responses after the fourth dose. Furthermore, increased age was associated with a poorer response. Finally, we observed that SARS-CoV-2 infection boosts both the cellular and humoral immune response, relative to vaccine-induced immunity alone. Conclusions Our findings highlight the boosting effect on T-cell immunity of repeated vaccine administration. The combination of multiple vaccine doses and SARS-CoV-2 infections maintains population T-cell immunity, although with reduced levels in the elderly. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Influence of incubation time on antimicrobial susceptibility testing of pathogenic Vibrio anguillarum and Vibrio vulnificus isolated from fish

Author

Baron, Sandrine, Ceccarelli, Daniela, Dalsgaard, Inger, Granier, Sophie A., Haenen, Olga, Jansson, Eva, Madsen, Lone, Jouy, Eric, Kempf, Isabelle, Larvor, Emeline, Morin, Thierry, Testerink, Joop, Veldman, Kees, Mouritsen, Kári Karbech, Van Gelderen, Betty, Voorbergen-Laarman, Michal, Säker, Eva, Blomkvist, Eva, and Smith, Peter

Published
2020
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26. Combining cross-sectional survey and register data improved the estimate of hepatitis C prevalence among patients attending a psychiatric emergency department in Denmark.

Author

Rose, Thomas Vemmelund, Christensen, Peer Brehm, Hjorth, Peter, Madsen, Lone Wulff, Hansen, Janne Fuglsang, Dröse, Sandra, Harvald, Gustav Bang, Røge, Birgit Thorup, and Øvrehus, Anne Lindebo Holm

Subjects
HEPATITIS C, PEOPLE with mental illness, HOSPITAL emergency services, POINT-of-care testing, PSYCHIATRIC emergencies, DATABASES
Abstract

The prevalence of hepatitis C (HCV) among psychiatric patients is elevated compared to the background population in many studies, but the prevalence among Danish psychiatric patients is unknown. The aim of the study was to determine the HCV prevalence and the proportion of the psychiatric patient population that remains to be diagnosed and treated in a Danish setting. During a 5-month period, patients attending the psychiatric emergency room in Vejle, Denmark, were offered point-of-care anti-HCV testing. Previous hepatitis C tests for all patients attending the Psychiatric Department in the study period were extracted from the national laboratory database (DANVIR). We combined the survey and register data in a capture–recapture estimate of undiagnosed patients with HCV. During the study 24.9% (589 of 2364) patients seen at the psychiatric department attended the emergency room. The prevalence of anti-HCV among those tested in the emergency room was 1.6%. The laboratory register identified 595/2364 patients previously tested for anti-HCV with a positive prevalence of 6.1%. The undiagnosed anti-HCV positives among the 1483 never tested was estimated to 1.1%. Thus the total estimated prevalence of anti-HCV was 2.3% (54/2364, 95% CI 1.7%–3.0%) in the population, of whom 70.4% had been diagnosed, and 72.2% of diagnosed patients had received treatment or cleared HCV. Combining survey and register data showed that the WHO target of 90% diagnosed and 80% treated was not met. To eliminate HCV in the psychiatric population, both undiagnosed and untreated patients must be targeted. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Combining cross-sectional survey and register data improved the estimate of hepatitis C prevalence among patients attending a psychiatric emergency department in Denmark

Author

Rose, Thomas Vemmelund, primary, Christensen, Peer Brehm, additional, Hjorth, Peter, additional, Madsen, Lone Wulff, additional, Hansen, Janne Fuglsang, additional, Dröse, Sandra, additional, Harvald, Gustav Bang, additional, Røge, Birgit Thorup, additional, and Øvrehus, Anne Lindebo Holm, additional

Published
2023
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28. Humoral antibody response following mRNA vaccines against SARS-CoV-2 in solid organ transplant recipients; a status after a fifth and bivalent vaccine dose

Author

Christophorou, Emma, primary, Nilsson, Anna Christine, additional, Petersen, Inge, additional, Lindvig, Susan O., additional, Davidsen, Jesper R., additional, Abazi, Rozeta, additional, Poulsen, Mikael K., additional, Pedersen, Rune M., additional, Justesen, Ulrik S., additional, Johansen, Nicolai E., additional, Bistrup, Claus, additional, Madsen, Lone W., additional, and Johansen, Isik S., additional

Published
2023
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34. SARS-CoV-2 vaccine-induced antibodies protect against Omicron breakthrough infection

Author

Baerends, Eva A.M., primary, Hvidt, Astrid K., additional, Reekie, Joanne, additional, Søgaard, Ole S., additional, Stærke, Nina B., additional, Raben, Dorthe, additional, Nielsen, Henrik, additional, Petersen, Kristine T., additional, Juhl, Maria R., additional, Johansen, Isik S., additional, Lindvig, Susan O., additional, Madsen, Lone W., additional, Wiese, Lothar, additional, Knudsen, Lene S., additional, Iversen, Mette B., additional, Benfield, Thomas, additional, Iversen, Kasper K., additional, Andersen, Sidsel D., additional, Juhl, Anna K., additional, Dietz, Lisa L., additional, Andreasen, Signe R., additional, Fischer, Thea K., additional, Erikstrup, Christian, additional, Valentiner-Branth, Palle, additional, Lundgren, Jens, additional, Østergaard, Lars, additional, Tolstrup, Martin, additional, Lundgren, J., additional, Østergaard, L., additional, Benfield, T., additional, Krohn-Dehli, L., additional, Petersen, D.K., additional, Fogh, K., additional, Højmark, E., additional, Iversen, K.K., additional, Bek, P., additional, Klastrup, V., additional, Larsen, F., additional, Rasmussen, S.H., additional, Schleimann, M.H., additional, Schieber, S., additional, Stærke, N.B., additional, Søndergaard, A., additional, Tarp, B., additional, Tousgaard, M., additional, Yehdego, Y., additional, Bodilsen, J., additional, Nielsen, H., additional, Petersen, K.T., additional, Ruwald, M., additional, Thisted, R.K., additional, Caspersen, S.F., additional, Iversen, M., additional, Knudsen, L.S., additional, Meyerhoff, J.L., additional, Sander, L.G., additional, Wiese, L., additional, Abildgaard, C., additional, Holden, I.K., additional, Johansen, N.E., additional, Johansen, I.S., additional, Larsen, L., additional, Lindvig, S.O., additional, Madsen, L.W., additional, Øvrehus, A., additional, Kruse, N.A., additional, Lomholdt, H., additional, Krause, T.G., additional, Valentiner-Branth, P., additional, Søborg, B., additional, Fischer, T.K., additional, Erikstrup, C., additional, Ostrowski, S.R., additional, Tolstrup, M., additional, Søgaard, O.S., additional, Raben, D., additional, Jylling, E., additional, Hougaard, D., additional, Andersen, S.D., additional, Lykkegaard, K., additional, Andreasen, S.R., additional, Baerends, E., additional, Dietz, L.L., additional, Hvidt, A.K., additional, Juhl, A.K., additional, Olesen, R., additional, Andersen, K.K., additional, Bannister, W., additional, Bjernved, C., additional, Elsing, T.W., additional, Esmann, F.V., additional, Ghafari, M.A., additional, Gravholdt, E., additional, Jakobsen, S.F., additional, Jakobsen, M.L., additional, Jensen, C.M., additional, Jensen, T.Ø., additional, Kristensen, D., additional, Kumar, L.R., additional, Matthews, C., additional, Normand, N., additional, Olsson, C., additional, Reekie, J., additional, Traytel, A., additional, Weide, T., additional, Hvas, A.M., additional, and Støvring, H., additional

Published
2023
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36. Omicron Variant-Specific Serological Imprinting Following BA.1 or BA.4/5 Bivalent Vaccination and Previous SARS-CoV-2 Infection: A Cohort Study

Author

Baerends, Eva A M, primary, Reekie, Joanne, additional, Andreasen, Signe R, additional, Stærke, Nina B, additional, Raben, Dorthe, additional, Nielsen, Henrik, additional, Petersen, Kristine T, additional, Johansen, Isik S, additional, Lindvig, Susan O, additional, Madsen, Lone W, additional, Wiese, Lothar, additional, Iversen, Mette B, additional, Benfield, Thomas, additional, Iversen, Kasper K, additional, Larsen, Fredrikke D, additional, Andersen, Sidsel D, additional, Juhl, Anna K, additional, Dietz, Lisa L, additional, Hvidt, Astrid K, additional, Ostrowski, Sisse R, additional, Krause, Tyra G, additional, Østergaard, Lars, additional, Søgaard, Ole S, additional, Lundgren, Jens, additional, and Tolstrup, Martin, additional

Published
2023
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46. Sustainable cockle fishery in the Limfjorden

Author

Freitas, Pedro Seabra, Petersen, Jens Kjerulf, Madsen, Lone, Jensen, Kurt Thomas, Nielsen, Pernille, Joyce, Patrick, Agüera, Antonio, Olsen, Jeppe, Krause, Kamille Elvstrøm, Saurel, Camille, Freitas, Pedro Seabra, Petersen, Jens Kjerulf, Madsen, Lone, Jensen, Kurt Thomas, Nielsen, Pernille, Joyce, Patrick, Agüera, Antonio, Olsen, Jeppe, Krause, Kamille Elvstrøm, and Saurel, Camille

Published
2023

47. Dissecting complex disease case in RAS by a validated microfluidic chip targeting salmonid pathogens

Author

Dalsgaard, Johanne, Sørensen, Juliane, Zarantonello, Giulia, Alonso, Alejandra Villamil, Madsen, Simon Brøndgaard, Cuenca, Argelia, Madsen, Lone, Moesgaard Iburg, Tine, Vendramin, Niccolò, Dalsgaard, Johanne, Sørensen, Juliane, Zarantonello, Giulia, Alonso, Alejandra Villamil, Madsen, Simon Brøndgaard, Cuenca, Argelia, Madsen, Lone, Moesgaard Iburg, Tine, and Vendramin, Niccolò

Published
2023

48. Social support and risk of mortality in cirrhosis:A cohort study

Author

Askgaard, Gro, Madsen, Lone Galmstrup, von Wowern, Natasja, Winther-Jensen, Matilde, Lau, Cathrine Juel, Christensen, Anne Illemann, Crooks, Colin, West, Joe, Jepsen, Peter, Askgaard, Gro, Madsen, Lone Galmstrup, von Wowern, Natasja, Winther-Jensen, Matilde, Lau, Cathrine Juel, Christensen, Anne Illemann, Crooks, Colin, West, Joe, and Jepsen, Peter

Abstract

Background & Aims: The function and structure of social relationships influence mortality in individuals within the general population. We compared aspects of social relationships in individuals with cirrhosis and a matched comparison cohort and studied their association with health-related quality of life (HRQoL) and mortality in cirrhosis. Methods: Individuals with cirrhosis and comparators were identified among participants of the Danish National Health Surveys 2010–2017. The surveys included questions on functional (social support and loneliness) and structural (living alone/cohabitating and frequency of contacts with relatives and friends) aspects of social relationships and HRQoL (Short Form-12). We estimated associations of aspects of social relationships with HRQoL and all-cause mortality in individuals with cirrhosis through 2020. Results: Of 541 individuals with cirrhosis and 2,157 comparators, low social support (22% in cirrhosis vs. 13% in comparators), loneliness (35% vs. 20%), and living alone (48% vs. 22%) were more frequent in individuals with cirrhosis than comparators, whereas the frequency of contacts with relatives and friends was similar. Except for living alone, weak functional and structural social relationships were associated with lower mental HRQoL in those with cirrhosis. Physical HRQoL was only marginally associated with social relationships. During 2,795 person-years of follow-up, 269 individuals with cirrhosis died. Functional and not structural aspects of social relationships were associated with risk of mortality in cirrhosis. Specifically, the adjusted hazard ratio was 1.4 (95% CI 1.1–1.9), p = 0.011, for low vs. moderate-to-high social support (functional aspect), and 1.0 (95% CI 0.8–1.3), p = 0.85 for living alone vs. cohabitating (structural aspect). Conclusions: Individuals with cirrhosis have weaker functional and structural social relationships than matched comparators. Weak functional relationships are associated with l

Published
2023

49. Fast and accurate identification by MALDI-TOF of the zoonotic serovar E of Vibrio vulnificus linked to eel culture

Author

Boonstra, M., Fouz, Belén, van Gelderen, E., Dalsgaard, Inger, Madsen, Lone, Jansson, Eva, Amaro, Carmen, Haenen, O.L.M., Boonstra, M., Fouz, Belén, van Gelderen, E., Dalsgaard, Inger, Madsen, Lone, Jansson, Eva, Amaro, Carmen, and Haenen, O.L.M.

Abstract

Vibrio vulnificus is a zoonotic pathogen that can cause death by septicaemia in farmed fish (mainly eels) and humans. The zoonotic strains that have been isolated from diseased eels and humans after eel handling belong to clade E (or serovar E (SerE)), a clonal complex within the pathovar (pv.) piscis. The aim of this study was to evaluate the accuracy of MALDI-TOF mass spectrometry (MS) in the identification of SerE, using the other two main pv. piscis-serovars (SerA and SerI) from eels as controls. MALDI-TOF data were compared with known serologic and genetic data of five pv. piscis isolates or strains, and with the non pv. piscis reference strain. Based on multiple spectra analysis, we found serovar-specific peaks that were of ~3098 Da and ~ 4045 Da for SerE, of ~3085 Da and ~ 4037 Da for SerA, and of ~3085 Da and ~ 4044 Da for SerI. Therefore, our results demonstrate that MALDI-TOF can be used to identify SerE and could also help in the identification of the other serovars of the species. This means that zoonosis due to V. vulnificus could be prevented by using MALDI-TOF, as action can be taken immediately after the isolation of a possible zoonotic V. vulnificus strain.

Published
2023

50. Environmental Enrichment for Rainbow Trout Fingerlings: A Case Study Using Shelters in an Organic Trout Farm

Author

Eidsmo, Julia, Madsen, Lone, Pedersen, Lars-Flemming, Jokumsen, Alfred, Gesto, Manuel, Eidsmo, Julia, Madsen, Lone, Pedersen, Lars-Flemming, Jokumsen, Alfred, and Gesto, Manuel

Abstract

Physical enrichment can improve the welfare of captive fish. Previous research has shown that fish often show preference for enriched environments, which can also result in improvements in growth performance. However, effects of enrichment are not always positive and the design and extent of the enrichment needs to be carefully considered. In this regard, information in real aquaculture scenarios is limited. The aim of this study was to serve as a proof of concept to test the feasibility of using simple PVC immersed shelters as a tool for better welfare in an organic rainbow trout farm. Our shelters induced little extra work in farm routines and had no negative effects on fish performance, health or mortality. The behavioral assessment pointed to a preference for sheltered areas in undisturbed conditions. However, no benefits were observed in terms of stress responses during standardized stress tests, and fish showed no obvious shelter‐seeking behavior after disturbance. The results in terms of shelter‐seeking behavior were probably limited by the short duration of the experiment, which was due to the farm’s routines and needs. It is recommended that strategies for enrichment in real scenarios should be tested covering a relevant part of the life cycle of the fish in captivity, to fully account for their potential to improve welfare in aquaculture

Published
2023

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