6 results on '"Madsen, Emilie Kabel"'
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2. Thromboembolic and bleeding events in ICU patients with COVID-19:A nationwide, observational study
- Author
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Russell, Lene, Weihe, Sarah, Madsen, Emilie Kabel, Hvas, Christine Lodberg, Leistner, Jens Wolfgang, Michelsen, Jens, Brøchner, Anne Craveiro, Bastiansen, Anders, Mølgaard Nielsen, Frederik, Meier, Nick, Andreasen, Anne Sofie, Ribergaard, Niels‐Erik, Rasmussen, Bodil Steen, Sølling, Christoffer Grant, Buck, David Levarett, Bundgaard, Helle, Pedersen, Helle Scharling, Darfelt, Iben Strøm, Poulsen, Lone Musaeus, Ibsen, Michael, Plovsing, Ronni R., Sigurdsson, Sigurdur T., Iversen, Susanne, Hildebrandt, Thomas, Mohr, Thomas, Espelund, Ulrick Skipper, Jørgensen, Vibeke, Haase, Nicolai, Perner, Anders, Russell, Lene, Weihe, Sarah, Madsen, Emilie Kabel, Hvas, Christine Lodberg, Leistner, Jens Wolfgang, Michelsen, Jens, Brøchner, Anne Craveiro, Bastiansen, Anders, Mølgaard Nielsen, Frederik, Meier, Nick, Andreasen, Anne Sofie, Ribergaard, Niels‐Erik, Rasmussen, Bodil Steen, Sølling, Christoffer Grant, Buck, David Levarett, Bundgaard, Helle, Pedersen, Helle Scharling, Darfelt, Iben Strøm, Poulsen, Lone Musaeus, Ibsen, Michael, Plovsing, Ronni R., Sigurdsson, Sigurdur T., Iversen, Susanne, Hildebrandt, Thomas, Mohr, Thomas, Espelund, Ulrick Skipper, Jørgensen, Vibeke, Haase, Nicolai, and Perner, Anders
- Abstract
Intensive care unit (ICU) patients with Coronavirus disease 2019 (COVID-19) have an increased risk of thromboembolic complications. We describe the occurrence of thromboembolic and bleeding events in all ICU patients with COVID-19 in Denmark during the first and second waves of the pandemic
- Published
- 2023
3. Thromboembolic and bleeding events in ICU patients with COVID ‐19: A nationwide, observational study
- Author
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Russell, Lene, primary, Weihe, Sarah, additional, Madsen, Emilie Kabel, additional, Hvas, Christine Lodberg, additional, Leistner, Jens Wolfgang, additional, Michelsen, Jens, additional, Brøchner, Anne Craveiro, additional, Bastiansen, Anders, additional, Nielsen, Frederik Mølgaard, additional, Meier, Nick, additional, Andreasen, Anne Sofie, additional, Ribergaard, Niels‐Erik, additional, Rasmussen, Bodil Steen, additional, Sølling, Christoffer Grant, additional, Buck, David Levarett, additional, Bundgaard, Helle, additional, Pedersen, Helle Scharling, additional, Darfelt, Iben Strøm, additional, Poulsen, Lone Musaeus, additional, Ibsen, Michael, additional, Plovsing, Ronni R., additional, Sigurdsson, Sigurdur T., additional, Iversen, Susanne, additional, Hildebrandt, Thomas, additional, Mohr, Thomas, additional, Espelund, Ulrick Skipper, additional, Jørgensen, Vibeke, additional, Haase, Nicolai, additional, and Perner, Anders, additional
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- 2022
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4. Thromboembolic and bleeding events in ICU patients with COVID‐19: A nationwide, observational study.
- Author
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Russell, Lene, Weihe, Sarah, Madsen, Emilie Kabel, Hvas, Christine Lodberg, Leistner, Jens Wolfgang, Michelsen, Jens, Brøchner, Anne Craveiro, Bastiansen, Anders, Nielsen, Frederik Mølgaard, Meier, Nick, Andreasen, Anne Sofie, Ribergaard, Niels‐Erik, Rasmussen, Bodil Steen, Sølling, Christoffer Grant, Buck, David Levarett, Bundgaard, Helle, Pedersen, Helle Scharling, Darfelt, Iben Strøm, Poulsen, Lone Musaeus, and Ibsen, Michael
- Subjects
COVID-19 ,THROMBOEMBOLISM ,HEMORRHAGE ,COVID-19 treatment ,INTENSIVE care units - Abstract
Background: Intensive care unit (ICU) patients with Coronavirus disease 2019 (COVID‐19) have an increased risk of thromboembolic complications. We describe the occurrence of thromboembolic and bleeding events in all ICU patients with COVID‐19 in Denmark during the first and second waves of the pandemic. Methods: This was a sub‐study of the Danish Intensive Care Covid database, in which all patients with SARS‐CoV‐2 admitted to Danish ICUs from 10th March 2020 to 30th June 2021 were included. We registered coagulation variables at admission, and all thromboembolic and bleeding events, and the use of heparins during ICU stay. Variables associated with thrombosis and bleeding and any association with 90‐day mortality were estimated using Cox regression analyses. Results: We included 1369 patients in this sub‐study; 158 (12%, 95% confidence interval 10–13) had a thromboembolic event in ICU and 309 (23%, 20–25) had a bleeding event, among whom 81 patients (6%, 4.8–7.3) had major bleeding. We found that mechanical ventilation and increased D‐dimer were associated with thrombosis and mechanical ventilation, low platelet count and presence of haematological malignancy were associated with bleeding. Most patients (76%) received increased doses of thromboprophylaxis during their ICU stay. Thromboembolic events were not associated with mortality in adjusted analysis (hazard ratio 1.35 [0.91–2.01, p =.14], whereas bleeding events were 1.55 [1.18–2.05, p =.002]). Conclusions: Both thromboembolic and bleeding events frequently occurred in ICU patients with COVID‐19. Based on these data, it is not apparent that increased doses of thromboprophylaxis were beneficial. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Low‐dose hydrocortisone in patients with COVID‐19 and severe hypoxia: The COVID STEROID randomised, placebo‐controlled trial
- Author
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Munch, Marie Warrer, primary, Meyhoff, Tine Sylvest, additional, Helleberg, Marie, additional, Kjær, Maj‐Brit Nørregaard, additional, Granholm, Anders, additional, Hjortsø, Carl Johan Steensen, additional, Jensen, Thomas Steen, additional, Møller, Morten Hylander, additional, Hjortrup, Peter Buhl, additional, Wetterslev, Mik, additional, Vesterlund, Gitte Kingo, additional, Russell, Lene, additional, Jørgensen, Vibeke Lind, additional, Kristiansen, Klaus Tjelle, additional, Benfield, Thomas, additional, Ulrik, Charlotte Suppli, additional, Andreasen, Anne Sofie, additional, Bestle, Morten Heiberg, additional, Poulsen, Lone Musaeus, additional, Hildebrandt, Thomas, additional, Knudsen, Lene Surland, additional, Møller, Anders, additional, Sølling, Christoffer Grant, additional, Brøchner, Anne Craveiro, additional, Rasmussen, Bodil Steen, additional, Nielsen, Henrik, additional, Christensen, Steffen, additional, Strøm, Thomas, additional, Cronhjort, Maria, additional, Wahlin, Rebecka Rubenson, additional, Jakob, Stephan M., additional, Cioccari, Luca, additional, Venkatesh, Balasubramanian, additional, Hammond, Naomi, additional, Jha, Vivekanand, additional, Myatra, Sheila Nainan, additional, Jensen, Marie Qvist, additional, Leistner, Jens Wolfgang, additional, Mikkelsen, Vibe Sommer, additional, Svenningsen, Jens S., additional, Laursen, Signe Bjørn, additional, Hatley, Emma Victoria, additional, Kristensen, Camilla Meno, additional, Al‐Alak, Ali, additional, Clapp, Esben, additional, Jonassen, Trine Bak, additional, Bjerregaard, Caroline Løkke, additional, Østerby, Niels Christian Haubjerg, additional, Jespersen, Mette Mindedahl, additional, Abou‐Kassem, Dalia, additional, Lassen, Mathilde Languille, additional, Zaabalawi, Reem, additional, Daoud, Mohammed Mahmoud, additional, Abdi, Suhayb, additional, Meier, Nick, additional, la Cour, Kirstine, additional, Derby, Cecilie Bauer, additional, Damlund, Birka Ravnholt, additional, Laigaard, Jens, additional, Andersen, Lene Lund, additional, Mikkelsen, Johan, additional, Jensen, Jeppe Lundholm Stadarfeld, additional, Rasmussen, Anders Hørby, additional, Arnerlöv, Emil, additional, Lykke, Mathilde, additional, Holst‐Hansen, Mikkel Zacharias Bystrup, additional, Tøstesen, Boris Wied, additional, Schwab, Janne, additional, Madsen, Emilie Kabel, additional, Gluud, Christian, additional, Lange, Theis, additional, and Perner, Anders, additional
- Published
- 2021
- Full Text
- View/download PDF
6. Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia:The COVID STEROID randomised, placebo-controlled trial
- Author
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Munch, Marie Warrer, Meyhoff, Tine Sylvest, Helleberg, Marie, Kjær, Maj Brit Nørregaard, Granholm, Anders, Hjortsø, Carl Johan Steensen, Jensen, Thomas Steen, Møller, Morten Hylander, Hjortrup, Peter Buhl, Wetterslev, Mik, Vesterlund, Gitte Kingo, Russell, Lene, Jørgensen, Vibeke Lind, Kristiansen, Klaus Tjelle, Benfield, Thomas, Ulrik, Charlotte Suppli, Andreasen, Anne Sofie, Bestle, Morten Heiberg, Poulsen, Lone Musaeus, Hildebrandt, Thomas, Knudsen, Lene Surland, Møller, Anders, Sølling, Christoffer Grant, Brøchner, Anne Craveiro, Rasmussen, Bodil Steen, Nielsen, Henrik, Christensen, Steffen, Strøm, Thomas, Cronhjort, Maria, Wahlin, Rebecka Rubenson, Jakob, Stephan M., Cioccari, Luca, Venkatesh, Balasubramanian, Hammond, Naomi, Jha, Vivekanand, Myatra, Sheila Nainan, Jensen, Marie Qvist, Leistner, Jens Wolfgang, Mikkelsen, Vibe Sommer, Svenningsen, Jens S., Laursen, Signe Bjørn, Hatley, Emma Victoria, Kristensen, Camilla Meno, Al-Alak, Ali, Clapp, Esben, Jonassen, Trine Bak, Bjerregaard, Caroline Løkke, Østerby, Niels Christian Haubjerg, Jespersen, Mette Mindedahl, Abou-Kassem, Dalia, Lassen, Mathilde Languille, Zaabalawi, Reem, Daoud, Mohammed Mahmoud, Abdi, Suhayb, Meier, Nick, la Cour, Kirstine, Derby, Cecilie Bauer, Damlund, Birka Ravnholt, Laigaard, Jens, Andersen, Lene Lund, Mikkelsen, Johan, Jensen, Jeppe Lundholm Stadarfeld, Rasmussen, Anders Hørby, Arnerlöv, Emil, Lykke, Mathilde, Holst-Hansen, Mikkel Zacharias Bystrup, Tøstesen, Boris Wied, Schwab, Janne, Madsen, Emilie Kabel, Gluud, Christian, Lange, Theis, Perner, Anders, Munch, Marie Warrer, Meyhoff, Tine Sylvest, Helleberg, Marie, Kjær, Maj Brit Nørregaard, Granholm, Anders, Hjortsø, Carl Johan Steensen, Jensen, Thomas Steen, Møller, Morten Hylander, Hjortrup, Peter Buhl, Wetterslev, Mik, Vesterlund, Gitte Kingo, Russell, Lene, Jørgensen, Vibeke Lind, Kristiansen, Klaus Tjelle, Benfield, Thomas, Ulrik, Charlotte Suppli, Andreasen, Anne Sofie, Bestle, Morten Heiberg, Poulsen, Lone Musaeus, Hildebrandt, Thomas, Knudsen, Lene Surland, Møller, Anders, Sølling, Christoffer Grant, Brøchner, Anne Craveiro, Rasmussen, Bodil Steen, Nielsen, Henrik, Christensen, Steffen, Strøm, Thomas, Cronhjort, Maria, Wahlin, Rebecka Rubenson, Jakob, Stephan M., Cioccari, Luca, Venkatesh, Balasubramanian, Hammond, Naomi, Jha, Vivekanand, Myatra, Sheila Nainan, Jensen, Marie Qvist, Leistner, Jens Wolfgang, Mikkelsen, Vibe Sommer, Svenningsen, Jens S., Laursen, Signe Bjørn, Hatley, Emma Victoria, Kristensen, Camilla Meno, Al-Alak, Ali, Clapp, Esben, Jonassen, Trine Bak, Bjerregaard, Caroline Løkke, Østerby, Niels Christian Haubjerg, Jespersen, Mette Mindedahl, Abou-Kassem, Dalia, Lassen, Mathilde Languille, Zaabalawi, Reem, Daoud, Mohammed Mahmoud, Abdi, Suhayb, Meier, Nick, la Cour, Kirstine, Derby, Cecilie Bauer, Damlund, Birka Ravnholt, Laigaard, Jens, Andersen, Lene Lund, Mikkelsen, Johan, Jensen, Jeppe Lundholm Stadarfeld, Rasmussen, Anders Hørby, Arnerlöv, Emil, Lykke, Mathilde, Holst-Hansen, Mikkel Zacharias Bystrup, Tøstesen, Boris Wied, Schwab, Janne, Madsen, Emilie Kabel, Gluud, Christian, Lange, Theis, and Perner, Anders
- Abstract
Background: In the early phase of the pandemic, some guidelines recommended the use of corticosteroids for critically ill patients with COVID-19, whereas others recommended against the use despite lack of firm evidence of either benefit or harm. In the COVID STEROID trial, we aimed to assess the effects of low-dose hydrocortisone on patient-centred outcomes in adults with COVID-19 and severe hypoxia. Methods: In this multicentre, parallel-group, placebo-controlled, blinded, centrally randomised, stratified clinical trial, we randomly assigned adults with confirmed COVID-19 and severe hypoxia (use of mechanical ventilation or supplementary oxygen with a flow of at least 10 L/min) to either hydrocortisone (200 mg/d) vs a matching placebo for 7 days or until hospital discharge. The primary outcome was the number of days alive without life support at day 28 after randomisation. Results: The trial was terminated early when 30 out of 1000 participants had been enrolled because of external evidence indicating benefit from corticosteroids in severe COVID-19. At day 28, the median number of days alive without life support in the hydrocortisone vs placebo group were 7 vs 10 (adjusted mean difference: −1.1 days, 95% CI −9.5 to 7.3, P =.79); mortality was 6/16 vs 2/14; and the number of serious adverse reactions 1/16 vs 0/14. Conclusions: In this trial of adults with COVID-19 and severe hypoxia, we were unable to provide precise estimates of the benefits and harms of hydrocortisone as compared with placebo as only 3% of the planned sample size were enrolled. Trial registration: ClinicalTrials.gov: NCT04348305. European Union Drug Regulation Authorities Clinical Trials (EudraCT) Database: 2020-001395-15.
- Published
- 2021
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