146 results on '"Madrid-Costa D"'
Search Results
2. Spontaneous corneal clearance after graft detachment in DMEK
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Fernández-Vega-Cueto, L., primary, Lisa, C., additional, Vasanthananthan, K., additional, Madrid-Costa, D., additional, Alfonso, J.F., additional, and Melles, G.R.J., additional
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- 2023
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3. Aclaramiento corneal espontáneo tras desprendimiento del injerto en DMEK
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Fernández-Vega-Cueto, L., primary, Lisa, C., additional, Vasanthananthan, K., additional, Madrid-Costa, D., additional, Alfonso, J.F., additional, and Melles, G.R.J., additional
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- 2023
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4. Optical power distribution of refractive and aspheric multifocal contact lenses: Effect of pupil size
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Madrid-Costa, D., Ruiz-Alcocer, J., García-Lázaro, S., Ferrer-Blasco, T., and Montés-Micó, R.
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- 2015
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5. Long-Term Follow-up of Intrastromal Corneal Ring Segments (210-Degree Arc Length) in Central Keratoconus With High Corneal Asphericity
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Lisa, C., Fernández-Vega Cueto, L., Poo-López, A., Madrid-Costa, D., and Alfonso, José F.
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- 2017
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6. Surgical Options for the Refractive Correction of Keratoconus: Myth or Reality
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Fernández-Vega-Cueto, L., Romano, V., Zaldivar, R., Gordillo, C. H., Aiello, F., Madrid-Costa, D., and Alfonso, J. F.
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genetic structures ,Article Subject ,sense organs ,eye diseases - Abstract
Keratoconus provides a decrease of quality of life to the patients who suffer from it. The treatment used as well as the method to correct the refractive error of these patients may influence on the impact of the disease on their quality of life. The purpose of this review is to describe the evidence about the conservative surgical treatment for keratoconus aiming to therapeutic and refractive effect. The visual rehabilitation for keratoconic corneas requires addressing three concerns: halting the ectatic process, improving corneal shape, and minimizing the residual refractive error. Cross-linking can halt the disease progression, intrastromal corneal ring segments can improve the corneal shape and hence the visual quality and reduce the refractive error, PRK can correct mild-moderate refractive error, and intraocular lenses can correct from low to high refractive error associated with keratoconus. Any of these surgical options can be performed alone or combined with the other techniques depending on what the case requires. Although it could be considered that the surgical option for the refracto-therapeutic treatment of the keratoconus is a reality, controlled, randomized studies with larger cohorts and longer follow-up periods are needed to determine which refractive procedure and/or sequence are most suitable for each case.
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- 2017
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7. Clinical Outcomes of Sequential Intrastromal Corneal Ring Segments and an Extended Range of Vision Intraocular Lens Implantation in Patients with Keratoconus and Cataract
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Lisa, C., primary, Zaldivar, R., additional, Fernández-Vega Cueto, A., additional, Sanchez-Avila, R. M., additional, Madrid-Costa, D., additional, and Alfonso, J. F., additional
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- 2018
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8. In vitro optical performance of a new aberration-free intraocular lens
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Madrid-Costa, D, primary, Ruiz-Alcocer, J, additional, Ferrer-Blasco, T, additional, García-Lázaro, S, additional, and Montés-Micó, R, additional
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- 2014
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9. Visual performance of a multifocal toric soft contact lens.
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Madrid-Costa D, Tomás E, Ferrer-Blasco T, García-Lázaro S, and Montés-Micó R
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- 2012
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10. Changes in accommodative responses with multifocal contact lenses: a pilot study.
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Madrid-Costa D, Ruiz-Alcocer J, Radhakrishnan H, Ferrer-Blasco T, and Montés-Micó R
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- 2011
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11. Accommodative functions with multifocal contact lenses: a pilot study.
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Montés-Micó R, Madrid-Costa D, Radhakrishnan H, Charman WN, and Ferrer-Blasco T
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- 2011
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12. Visual and optical performance with hybrid multifocal intraocular lenses.
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Madrid-Costa D, Cerviño A, Ferrer-Blasco T, García-Lázaro S, and Montés-Micó R
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- 2010
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13. OCT for Assessing Artificial Tears Effectiveness in Contact Lens Wearers.
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Garcia-Lázaro S, Madrid-Costa D, Ferrer-Blasco T, Montés-Micó R, and Cerviño A
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- 2012
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14. Stereoacuity with simultaneous vision multifocal contact lenses.
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Ferrer-Blasco T and Madrid-Costa D
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- 2010
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15. Reply.
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Alfonso-Bartolozzi B, Fernández-Vega-Cueto L, Fernández-Vega L, Martínez-Alberquilla I, Madrid-Costa D, and Alfonso JF
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- Humans
- Abstract
Competing Interests: The authors have no funding or conflicts of interest to disclose.
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- 2024
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16. Evaluation of repeatability and agreement of two optical biometers for intraocular lens power calculation.
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Alberquilla IM, Svensson S, Ruiz-Alcocer J, Madrid-Costa D, Dominguez-Vicent A, and Venkataraman AP
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- Humans, Male, Female, Middle Aged, Aged, Reproducibility of Results, Adult, Axial Length, Eye, Anterior Chamber, Refraction, Ocular physiology, Optics and Photonics instrumentation, Lenses, Intraocular, Biometry instrumentation, Biometry methods
- Abstract
The repeatability of two biometers (Lenstar-LS900 and Eyestar-900) to measure ocular parameters and intraocular lens (IOL) power calculation, and their agreement were evaluated. 134 eyes of 134 participants were measured thrice with each biometer. Axial length (AL), anterior chamber depth (ACD), lens thickness (LT) and keratometry (K) were evaluated. The IOL power was calculated using different formulas. The repeatability limit (RLimit), the mean differences (MD) and the limits of agreement (LoA) were calculated. The RLimits for all parameters were higher with Lenstar compared to Eyestar. RLimits were lower than 0.50 D except for Barrett Universal II (0.54 D) and Haigis (0.51 D) formulas with the Lenstar. Mean differences were lower than 0.01 mm for AL, ACD and LT, and lower than 0.03 D for K. MD ranged from 0 to 0.02 D for all formulas except for Barrett and Hill. When dividing the sample into subgroups (short, normal and long eyes), the MDs were similar for the IOL power and were lower than 0.03 D, except for the Barrett and Hill formulas. Both biometers provide repeatable biometry and IOL power calculations. The LoA interval for the IOL power calculation was between 0.75 and 1.50D, which was similar among the subgroups., (© 2024. The Author(s).)
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- 2024
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17. Ten-year follow-up of posterior chamber phakic intraocular lens with central port design in patients with low and normal vault.
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Alfonso-Bartolozzi B, Fernández-Vega-Cueto L, Lisa C, Palacios A, Madrid-Costa D, and Alfonso JF
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- Humans, Retrospective Studies, Follow-Up Studies, Female, Male, Adult, Endothelium, Corneal pathology, Cell Count, Young Adult, Middle Aged, Prosthesis Design, Phakic Intraocular Lenses, Visual Acuity physiology, Lens Implantation, Intraocular, Intraocular Pressure physiology, Refraction, Ocular physiology, Postoperative Complications, Myopia surgery, Myopia physiopathology
- Abstract
Purpose: To assess the clinical outcomes and postoperative complications of the implantable collamer lens (ICL) with a central port throughout 10 years of follow-up in patients with low and normal vault., Setting: Fernández-Vega Ophthalmological Institute, Oviedo, Spain., Design: Retrospective and comparative case series., Methods: This study included eyes that underwent a V4c ICL implantation with 10 years of follow-up. The eyes were divided into 2 groups according to the vault at 1 year postoperatively: vault <250 μm and between 250 μm and 800 μm. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), intraocular pressure (IOP), endothelial cell density (ECD), vault, complications, and secondary surgeries were analyzed., Results: 37 and 90 eyes were enrolled in the low and normal-vault groups, respectively. No differences in UDVA, CDVA, and refraction were found between the groups over 10 years of follow-up. No cases developed ICL-induced anterior subcapsular opacity over the follow-up period. 2 (5.4%) and 8 (8.9%) eyes in the low and normal-vault groups, respectively, required ICL exchange. 1 (2.8%) and 2 (2.2%) eyes in the low and normal-vault groups, respectively, required excimer laser to correct residual refractive error. The IOP remained stable throughout the 10-year follow-up. The loss in ECD from that preoperatively to 10 years postoperatively was 3.8% and 4.5% in the low and normal-vault groups, respectively ( P = .4). No pigment dispersion glaucoma or other vision-threatening complications were reported., Conclusions: This study shows good long-term outcomes of the V4c ICL, supporting that the central hole provides safety to the procedure and prevents the potential risk associated with low vault., (Copyright © 2023 Published by Wolters Kluwer on behalf of ASCRS and ESCRS.)
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- 2024
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18. Triple Procedure: A Stepwise Combination of Deep Anterior Lamellar Keratoplasty and Cataract Surgery.
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Alfonso-Bartolozzi B, Fernández-Vega-Cueto L, Fernández-Vega L, Martínez-Alberquilla I, Madrid-Costa D, and Alfonso JF
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- Humans, Lens Implantation, Intraocular methods, Keratoplasty, Penetrating methods, Refraction, Ocular, Visual Acuity, Retrospective Studies, Astigmatism surgery, Phacoemulsification adverse effects, Cataract complications, Lenses, Intraocular adverse effects
- Abstract
Purpose: The aim of this study was to evaluate clinical outcomes of the combined surgery (triple procedure) of deep anterior lamellar keratoplasty (DALK), phacoemulsification, and intraocular lens (IOL) implantation using a new surgical strategy., Methods: The study included 43 eyes of 43 patients who underwent a triple procedure. Twenty-six eyes with good visibility through the cornea underwent phacoemulsification before the stromal dissection. Seventeen eyes with bad visibility underwent the DALK procedure first until achieving enough visibility to perform the lensectomy. IOL power calculation was performed for a postoperative estimated flat keratometry of 43.5 and aiming to avoid hyperopic postoperative refraction. The postoperative visual examination included uncorrected and corrected distance visual acuity (CDVA) measurements and manifest refraction., Results: The mean follow-up time after suture removal was 3.06 ± 2.14 years. Mean CDVA significantly changed from 0.86 ± 0.56 logMAR preoperatively to 0.37 ± 0.28 logMAR in the last visit ( P < 0.0001). The percentage of eyes with CDVA ≤0.3 logMAR changed from 6.9% preoperatively to 62.8%. No eyes lost lines of vision after surgery, and 80% experienced an improvement of 2 or more lines. The safety index was 2.2. The mean postoperative refractive sphere was +0.13 ± 2.04 D, and the postoperative refractive cylinder was -4.02 ± 2.24 D. Only 2 cases (4.65%) obtained postoperative hyperopic astigmatism. No intraoperative complications were found., Conclusions: Combined surgery of DALK, phacoemulsification, and IOL implantation is an effective and safe procedure. Depending on the corneal transparency, different surgical strategies can be established to provide more efficacy and safety., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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19. Reply to comment on: Recommendation for presbyopia-correcting intraocular lenses: A Delphi consensus statement by the ESASO study group.
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Romano V, Madrid-Costa D, Alfonso JF, Alio J, Allan B, Angunawela R, Auffarth G, Carones F, Khoramnia R, Moore J, Nanavaty MA, Savini G, Pagano L, Romano MR, Virgili G, and Fernández-Vega-Cueto L
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- Humans, Delphi Technique, Lens Implantation, Intraocular, Eye, Artificial, Presbyopia surgery, Lenses, Intraocular
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- 2024
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20. Effect of intrastromal corneal ring segments on in vivo corneal biomechanics in keratoconus: 1-year results.
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Vinciguerra R, Fernández-Vega-Cueto L, Roberts CJ, Poo-Lopez A, Eliasy A, Merayo-Lloves J, Elsheikh A, Madrid-Costa D, Lisa C, and Alfonso JF
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- Humans, Biomechanical Phenomena, Prospective Studies, Cornea surgery, Academies and Institutes, Keratoconus surgery
- Abstract
Purpose: To evaluate the 1-year effects of the implantation of intrastromal corneal ring segments (ICRS) in keratoconus (KC) on the dynamic corneal response (DCR) parameters obtained with the Corvis., Setting: Fernández-Vega Ophthalmological Institute, Oviedo, Spain., Design: Prospective, single-center, clinical study., Methods: Included were patients who underwent ICRS implantation for KC over a period of 1 year. On the day of the surgery and at least 6 months after ICRS implantation, the following measurements were made: corrected distance and uncorrected distance visual acuity, corneal tomography indices with the Pentacam, biomechanically corrected intraocular pressure and the Corvis DCRs (integrated inverse concave radius, deformation amplitude ratio, stiffness parameter at first applanation, stress-strain index [SSI] and the highest concavity radius)., Results: 30 eyes were included with a mean follow-up time of 15 months. Statistical analysis showed that ICRS implantation induced significant improvements in corneal biomechanics measurements between preoperative and long-term follow-up as demonstrated by a significant increase in SSI (P = .003). To confirm that this difference was actually induced due to a stiffening between early postoperative (previously published) and long-term an additional t-test was done between month 1 and late follow-up which confirmed a significant stiffening in the value of SSI (P = .01)., Conclusions: Patients implanted with ICRS alone for KC showed a significantly stiffer response due to increased structural support compared with preoperative values and 1 month postoperative., (Copyright © 2023 Published by Wolters Kluwer on behalf of ASCRS and ESCRS.)
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- 2023
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21. Clinical and Aberrometric Outcomes of a New Implantable Collamer Lens for Myopia and Presbyopia Correction in Phakic Patients.
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Alfonso JF, Fernández-Vega-Cueto L, Lisa C, Alfonso-Bartolozzi B, Palacios A, and Madrid-Costa D
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- Humans, Middle Aged, Coma, Refraction, Ocular, Presbyopia surgery, Myopia surgery, Lenses, Intraocular
- Abstract
Purpose: To assess the clinical and aberrometric outcomes of a new Implantable Collamer Lens (EVO Viva ICL; STAAR Surgical) to correct moderate to high myopia and presbyopia., Methods: The study included 80 eyes of 40 patients who had bilateral EVO Viva ICL implantation. Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, presbyopic add power, binocular through-focus visual acuity, total ocular spherical aberration (SA), coma aberration, and root mean square of ocular higher order aberrations (RMS HOAs) (i-Trace Aberrometer; Tracey Technologies) for a 4.5-mm pupil size were evaluated., Results: The mean binocular postoperative UDVA and CDVA were 0.09 ± 0.19 and 0.02 ± 0.03 logMAR, respectively. The postoperative spherical equivalent was -0.61 ± 0.54 diopters (D). The presbyopic add power reduced from +1.31 ± 0.74 D preoperatively to +0.44 ± 0.58 D after surgery ( P < .0001). The mean visual acuity was 0.1 logMAR or better (20/25 or better) across the vergence range from +0.50 to -1.50 D, better than 0.2 logMAR (20/32 or better) up to the vergence of -2.00 D, and remained better than 0.3 logMAR (20/40 or better) up to the vergence of -2.50 D. The total ocular aberrations induced by EVO Viva ICL were -0.34 ± 0.09 µm of SA, 0.24 ± 0.18 µm of coma, and 0.26 ± 0.12 µm of RMS HOAs., Conclusions: The outcomes support that the new ICL might be a good alternative for myopia and presbyopia correction in patients aged between 45 and 55 years. Further studies are needed to evaluate the threshold lens misalignment from which the patient´s visual quality would be affected. [ J Refract Surg . 2023;39(9):589-596.] .
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- 2023
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22. Recommendation for Presbyopia-Correcting Intraocular Lenses: A Delphi Consensus Statement by the ESASO Study Group.
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Romano V, Madrid-Costa D, Alfonso JF, Alio J, Allan B, Angunawela R, Auffarth G, Carones F, Khoramnia R, Moore J, Nanavaty MA, Savini G, Pagano L, Romano MR, Virgili G, and Fernández-Vega-Cueto L
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- Humans, Delphi Technique, Lens Implantation, Intraocular, Prosthesis Design, Presbyopia surgery, Lenses, Intraocular, Color Vision
- Abstract
Purpose: To establish consensus among experts in lens and refractive surgery to guide general ophthalmologists on issues related to presbyopia-correcting intraocular lenses (IOLs)., Design: A modified Delphi method to reach a consensus among experts., Methods: A steering committee formulated 105 relevant items grouped into four sections (preoperative considerations, IOL selection, intraoperative considerations, and postoperative considerations). The consensus was defined as ≥ 70% of experts agreeing with the evaluation of a statement., Results: Ten experts participated and completed all rounds of questionnaires (100% response rate). Of 68 items considered in the preoperative considerations, consensus was achieved in 48 (70.6%). There was a lack of consensus over IOL selection, the experts only agreed on the importance of the patient's habits for the optical IOL design selection. Of the 14 considerations related to intraoperative issues, the experts reached a consensus on 10 (71.4%). The postoperative considerations section reached the highest consensus in 10 items of 13 (76.9%)., Conclusions: Key recommendations for a diffractive multifocal IOL were a potential postoperative visual acuity > 0.5, a keratometry between 40-45 diopters, a pupil >2.8 mm under photopic conditions and <6.0 mm under scotopic conditions, a root mean square of higher order corneal aberrations <0.5 µm for 6-mm pupil size, while monofocal or non-diffractive IOLs should be considered for patients with coexisting eye disorders. A lack of agreement was found in the issues related to the IOL selection., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
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- 2023
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23. Intrastromal Corneal Ring Segments Implantation After Deep Anterior Lamellar Keratoplasty for Astigmatism Correction: Mid-term and Long-term Follow-up.
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Alfonso-Bartolozzi B, Fernández-Vega-Cueto L, Poo-López A, Lisa C, Madrid-Costa D, and Alfonso JF
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- Humans, Follow-Up Studies, Retrospective Studies, Corneal Stroma surgery, Prosthesis Implantation, Refraction, Ocular, Corneal Topography, Astigmatism surgery, Corneal Transplantation, Keratoconus surgery
- Abstract
Purpose: The aim of this study was to assess the long-term outcomes of implanting intrastromal corneal ring segments (ICRSs) using a femtosecond laser for correcting astigmatism in patients who had previous deep anterior lamellar keratoplasty (DALK) throughout a 5-year follow-up period., Methods: This retrospective study included 40 eyes of 40 patients with previous DALK and astigmatism ≥3.00 D who underwent Ferrara-type ICRS implantation. The manifest refraction, uncorrected (UDVA) and corrected (CDVA) distance visual acuity (logMAR), and corneal topography were recorded preoperatively and at 6, 12, 36, and 60 months postoperatively., Results: The mean UDVA (logMAR scale) improved from 1.39 ± 0.55 preoperatively to 0.71 ± 0.37 at 6 months postoperatively ( P < 0.0001). The mean CDVA (logMAR) significantly improved from 0.36 ± 0.17 to 0.22 ± 0.12 at 6 months after surgery ( P < 0.0001). Both UDVA and CDVA remained unchanged throughout the follow-up ( P = 0.09). Postoperatively, no eyes lost lines of CDVA compared to preoperatively, and around 80% of the eyes gained lines of CDVA. The safety index remained stable at a value of 1.4 throughout the follow-up. The refractive cylinder decreased from -6.86 ± 2.62 D preoperatively to -2.33 ± 1.09D at 6 months postoperatively ( P < 0.0001), and subsequently, it was stable over the postoperative period ( P = 0.2). The maximum and minimum keratometry measurements significantly decreased after surgery and remained stable over the postoperative follow-up period ( P > 0.07)., Conclusions: This study shows the long-term viability of Ferrara-type ICRS implantation using a femtosecond laser as a surgical alternative for astigmatism correction in post-DALK eyes., Competing Interests: The authors have no funding or conflicts of interest to disclose., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2023
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24. Long-Term Follow-Up of a 150° Arc-Length Intrastromal Corneal Ring Segment Implantation in Post-LASIK Ectasia.
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Ibares-Frías L, Fernández-Vega-Cueto L, Alfonso-Bartolozzi B, Poo-López A, Madrid-Costa D, and Alfonso JF
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- Humans, Follow-Up Studies, Corneal Stroma surgery, Dilatation, Pathologic surgery, Coma surgery, Prosthesis Implantation, Refraction, Ocular, Prostheses and Implants, Corneal Topography, Retrospective Studies, Keratomileusis, Laser In Situ adverse effects, Keratoconus surgery
- Abstract
Purpose: To evaluate the outcomes of implanting a 150° arc-length intrastromal corneal ring segment (ICRS) using a femtosecond laser in patients with post-LASIK ectasia throughout a 5-year follow-up period., Methods: This study enrolled 45 eyes of 45 patients diagnosed with post-LASIK ectasia who underwent a 150° arc-length Ferrara-type ICRS implantation. The uncorrected (UDVA) and corrected (CDVA) distance visual acuities, residual refractive errors, and root mean square (RMS) for coma-like aberration were evaluated preoperatively and at 6-, 12-, 36, and 60 months postoperatively., Results: Mean UDVA (logMAR) ameliorated from 0.53 ± 0.33 preoperatively to 0.26 ± 0.24 at 6 months postoperatively ( p < 0.0001). Mean CDVA improved from 0.12 ± 0.13 to 0.04 ± 0.06 ( p < 0.0001). Mean UDVA and CDVA remained stable throughout the 5-year follow-up ( p > 0.1). No eyes lost lines of CDVA at any follow-up visit compared to preoperatively, and most eyes gained lines. The eyes with a refractive cylinder ≤ 2.00 D varied from 26.7% preoperatively to more than 75% at all postoperative follow-up visits. The maximum keratometry was significantly flattened ( p < 0.0001), and the RMS for corneal coma-like aberration was halved ( p < 0.0001). 93.3% of the eyes did not show signs of disease progression or regression of the visual or refractive outcomes at any follow-up visits., Conclusion: These results suggest that implanting a single 150° arc-length Ferrara-type ICRS is a safe, effective and stable procedure for visual restoration in post-LASIK ectasia. In very few cases, visual and/or refractive instability was experienced throughout the follow-up.
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- 2023
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25. Refractive surgery after deep anterior lamellar keratoplasty: a review of the literature.
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Alfonso-Bartolozzi B, Martínez-Alberquilla I, Baamonde B, Fernández-Vega-Cueto L, Alfonso JF, and Madrid-Costa D
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- Humans, Keratoplasty, Penetrating methods, Visual Acuity, Refraction, Ocular, Treatment Outcome, Refractive Errors etiology, Refractive Surgical Procedures adverse effects, Astigmatism surgery, Corneal Transplantation methods
- Abstract
Purpose: The main objective of this work is to present an updated review of the different surgical procedures for the correction of residual refractive errors following deep anterior lamellar keratoplasty (DALK) surgery., Methods: A review of the literature was conducted using PubMed, Web of Science, and Scopus databases. The search was conducted in January 2022 and was limited to articles published in peer-reviewed journals. The information extracted from each publication included sample size, mean follow-up time, pre- and post-operative uncorrected (UDVA) and corrected distance visual acuity (CDVA), pre- and post-operative refraction and spherical equivalent (SE), safety and efficacy indexes and complications., Results: Residual ametropias, mainly high astigmatism and myopia, and the resulting anisometropia are likely to occur following DALK. They become a limiting factor and may lead to unsatisfactory visual restoration, therefore affecting patients' quality of vision and life. Alternative surgical interventions may be required to treat this residual ametropia, such as corneal refractive surgery or intraocular lens implantation. A total of 47 relevant articles were studied in detail. Different refractive surgery techniques have been shown to be effective and safe for the correction of ametropia following the DALK procedure and to improve the patient's quality of vision, although more research is needed to confirm long-term results., Conclusion: The final refractive technique will depend on different factors, such as the amount of ametropia, the condition of the cornea or the patient's individual needs, economics, and occupational demands., (© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2023
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26. Reply: Efficacy of Enhanced Monofocal Intraocular Lens in Eyes With High Hyperopia.
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Fernández-Vega-Cueto L, Vega F, Guerra-Velasco R, Millán MS, Madrid-Costa D, and Alfonso JF
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- Humans, Lens Implantation, Intraocular, Refraction, Ocular, Hyperopia surgery, Lenses, Intraocular, Eye Diseases, Hereditary, Phacoemulsification
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- 2023
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27. Beam-Shaping Extended Depth of Focus Intraocular Lens: Optical Assessment With Corneas of Increasing Spherical Aberration.
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Madrid-Costa D, Fernández-Vega-Cueto L, Azor-Morón JA, Vega F, Millán MS, and Alfonso JF
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- Humans, Visual Acuity, Vision, Ocular, Cornea, Prosthesis Design, Depth Perception, Lenses, Intraocular
- Abstract
Purpose: To assess the optical quality and halo formation of a beam-shaping extended depth-of-focus (EDOF) intraocular lens (IOL) (AcrySof IQ Vivity; Alcon Laboratories, Inc) with corneas of long-range spherical aberration (SA) such as those resulting from myopic laser ablations., Methods: The optical quality of the EDOF IOL and a reference monofocal IOL was evaluated with three corneas (A, B, and C, with SA =+0.135, +0.290, +0.540 µm, respectively, for a 5.15-mm pupil at the IOL plane). The through-focus modulation transfer function area (MTFa) curves were obtained between -5.00 and +2.00 diopters (D) defocus range. The halo was also assessed with the three corneas., Results: Through-focus MTFa curves for a 4.5-mm IOL pupil showed a slight decrease in the maximum MTFa value provided by the EDOF IOL compared to the monofocal IOL in the three corneal situations (A: 45.9 vs 38.6 units; B: 41.1 vs 33.1 units, and C: 26.9 vs 23.8 units). For the 3.0-mm pupil, the EDOF IOL also had lower maximum MTFa than the monofocal IOL; however, the depth-of-focus increased to -2.20 D. With corneas A and B, the halo induced was of low energy with both IOLs. With cornea C, the EDOF IOL created a much larger and intense halo., Conclusions: The EDOF IOL provided a good distance optical performance and an extended range of focus of approximately 2.00 D, with a halo of low intensity when evaluated with a corneal SA similar to the one induced by a low to moderate myopic ablation. With a high myopic ablation, the halo induced would be of considerable size and energy. [ J Refact Surg. 2023;39(2):95-102.] .
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- 2023
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28. Presbyopia: An outstanding and global opportunity for early detection of pre-frailty and frailty states.
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Crooke A, Martínez-Alberquilla I, Madrid-Costa D, and Ruiz-Alcocer J
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Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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- 2022
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29. Three-year follow-up of posterior chamber phakic intraocular lens with a central port design after deep anterior lamellar keratoplasty.
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Alfonso-Bartolozzi B, Lisa C, Fernández-Vega-Cueto L, Baamonde B, Madrid-Costa D, and Alfonso JF
- Abstract
Background: To evaluate clinical outcomes of the Visian implantable collamer lens (ICL) with a central port to correct myopia and astigmatism after deep anterior lamellar keratoplasty (DALK) for keratoconus throughout 3 years of follow-up., Methods: This study included 20 eyes of 20 patients that underwent V4c ICL (13 eyes with a spherical ICL and 7 eyes with a toric ICL) implantation after DALK. Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, intraocular pressure (IOP), endothelial cell density (ECD), and vault were analyzed., Results: The mean UDVA improved from the preoperative 1.18 ± 0.33 logMAR to 0.25 ± 0.14 logMAR at 6 months after surgery (P < 0.0001) and remained unchanged throughout the whole follow-up (P = 0.4). All eyes gained lines of CDVA compared to preoperative values. At the last follow-up visit, all eyes achieved CDVA of 0.2 logMAR or better and 13 eyes (65%) 0.1 logMAR or better. At 6 months post-surgery, all eyes (100%) had a spherical equivalent within ± 1.50 D, and 19 (95%) within ± 1.00 D. The mean manifest spherical equivalent was stable over the postoperative follow-up (P = 0.25). No significant increase in IOP occurred in any case throughout the 3 years of follow-up. The loss in ECD from the preoperative baseline at the last follow-up visit was 2.27%., Conclusions: The clinical outcomes suggest that the V4c ICL implantation for correction of myopia and regular astigmatism in post-DALK eyes was satisfactory in terms of effectiveness, safety, and stability during 3 years of follow-up., (© 2022. The Author(s).)
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- 2022
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30. Optical and Clinical Outcomes of an Enhanced Monofocal Intraocular Lens for High Hyperopia.
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Fernández-Vega-Cueto L, Vega F, Guerra-Velasco R, Millán MS, Madrid-Costa D, and Alfonso JF
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- Eye Diseases, Hereditary, Humans, Lens Implantation, Intraocular, Prosthesis Design, Refraction, Ocular, Hyperopia surgery, Lenses, Intraocular, Phacoemulsification
- Abstract
Purpose: To evaluate the optical and clinical performance of an enhanced monofocal intraocular lens (IOL) (TECNIS Eyhance ICB00; Johnson & Johnson Vision) in patients with high hyperopia and a short axial length., Methods: Power mapping, wavefront analysis, and the through-focus modulation transfer function area (TF-MTFa) were measured in vitro for three IOL powers (10.00, 20.00, and 30.00 diopters [D]). The clinical study included 22 patients with an axial length of less than 22.5 mm. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity and binocular defocus curve were evaluated 6 months postoperatively., Results: For the three IOL powers, the power mapping revealed an increase in positive power from the periphery to the center of the lens, providing an extra positive correction of 1.00 D for a 2-mm pupil size. The TF-MTFa curves showed only a peak of maximum MTFa at the distance focus. As the pupil size became smaller, there was a focus extension effect, providing an extended depth of focus of up to -1.50 D for a 2-mm pupil size. No significant dependency of the IOL base power on the power profile, wavefront, or optical quality was found. The clinical outcomes showed that all patients achieved a binocular CDVA of 0.1 logMAR or better. The mean visual acuity was better than 0.1 logMAR between +0.50 and -1.50 D of defocus. At a vergence of -2.00 D, the visual acuity was 0.11 ± 0.13 logMAR., Conclusions: The monofocal enhanced IOL provided good distance optical and visual quality and optimal visual acuity up to an intermediate-near vision distance of 50 to 40 cm in patients with high hyperopia and a short axial length. [ J Refract Surg . 2022;38(9):572-579.] .
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- 2022
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31. Femto-LASIK after Deep Anterior Lamellar Keratoplasty to Correct Residual Astigmatism: A Long-Term Case Series Study.
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Alfonso-Bartolozzi B, Lisa C, Fernández-Vega-Cueto L, Madrid-Costa D, and Alfonso JF
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- Humans, Lasers, Excimer, Retrospective Studies, Treatment Outcome, Astigmatism etiology, Astigmatism surgery, Corneal Transplantation methods, Keratomileusis, Laser In Situ adverse effects, Keratomileusis, Laser In Situ methods
- Abstract
Purpose: To evaluate the long-term outcomes of femtosecond laser-assisted in situ keratomileusis (Femto-LASIK) to correct residual astigmatism after deep anterior lamellar keratoplasty (DALK). Methods: This retrospective case series study included 10 eyes that underwent Femto-LASIK after a DALK. The refractive error, uncorrected (UDVA) and corrected (CDVA) distance visual acuities, thinnest corneal thickness (TCT), and central corneal thickness (CCT) were registered. The postoperative follow-up ranged between 36 and 60 months. Results: All surgeries were uneventful, with no intra- or postoperative complications. The mean UDVA (Snellen scale) rose from 0.13 ± 0.05 to 0.47 ± 0.15 six months after Femto-LASIK (p < 0.001). All cases experienced a significant improvement in UDVA. None of the eyes lost lines of CDVA, and seven eyes (70%) improved the CDVA compared to preoperative values. The refractive cylinder changed from a preoperative value of −3.88 ± 1.00 D to −0.93 ± 0.39 six months after Femto-LASIK (p < 0.0001). In eight eyes (80%), the UDVA and refractive outcomes remained stable at postoperative follow-up visits. In contrast, one eye experienced a refractive regression over the follow-up. TCT and CCT were stable at the different postoperative follow-up visits. Conclusions: Our findings suggest that Femto-LASIK might safely and effectively corrects residual astigmatism after DALK. Despite these encouraging results, further long-term studies, including a larger number of cases, are required to confirm the safety of the procedure. The refractive stability in eyes with prior RK might be lower than for other DALK indications.
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- 2022
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32. The Effect of Intracorneal Ring Segments Implantation for Keratoconus on In Vivo Corneal Biomechanics Assessed With the Corvis ST.
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Vinciguerra R, Fernández-Vega-Cueto L, Poo-Lopez A, Eliasy A, Merayo-Lloves J, Elsheikh A, Madrid-Costa D, Lisa C, and Alfonso JF
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- Biomechanical Phenomena, Cornea surgery, Corneal Topography methods, Humans, Prospective Studies, Keratoconus surgery
- Abstract
Purpose: To evaluate the effect of the implantation of intracorneal ring segments (ICRS) in keratoconus on the dynamic corneal response (DCR) parameters obtained with the Corvis ST (Oculus Optikgeräte GmbH)., Methods: This prospective clinical study included patients who underwent ICRS implantation for keratoconus over a period of 1 year. On the day of the surgery and at least 1 month after ICRS implantation, the following measurements were made: corrected and uncorrected distance visual acuity, corneal tomography indices with the Pentacam (Oculus Optikgeräte GmbH), biomechanically corrected intraocular pressure (bIOP), Corvis ST DCR parameters, integrated inverse concave radius (1/R), deformation amplitude ratio (DA ratio), stiffness parameter at first applanation (SP-A1), stress-strain index (SSI), and highest concavity radius (HRC)., Results: Fifty-one eyes of 40 patients were included with a median follow-up time of 3 months (interquartile ratio [IQR]: 2 to 6 months). Statistical analysis showed that ICRS implantation did not affect corneal biomechanical measurements evaluated with the Corvis ST, which was demonstrated by non-significant changes in the SP-A1 ( P = .637), 1/R ( P = .647), HRC ( P = .177), DA ratio ( P = .735), and SSI ( P = .501). Additionally, the results showed that bIOP measurements were not significantly affected by ICRS implantation ( P = .113)., Conclusions: ICRS implantation does not affect corneal biomechanical measurements in early follow-up. [ J Refract Surg . 2022;38(4):264-269.] .
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- 2022
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33. Optical and Clinical Outcomes of an Extended Range of Vision Intraocular Lens.
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Fernández-Vega-Cueto L, Madrid-Costa D, Alfonso-Bartolozzi B, Vega F, Millán MS, and Alfonso JF
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- Humans, Prospective Studies, Prosthesis Design, Refraction, Ocular, Lens Implantation, Intraocular, Lenses, Intraocular
- Abstract
Purpose: To assess the in vitro optical quality and halo formation of the AcrySof IQ Vivity intraocular lens (IOL) (Alcon Laboratories, Inc) and to evaluate the clinical outcomes in patients who had bilateral implantation of this IOL., Methods: The optical quality was evaluated with the PMTF optical bench (Lambda-X). Through-focus modulation transfer function area (MTFa) curves between -5.00 and +2.00 diopters (D) were obtained for 3- and 4.5-mm pupil apertures. The halo was assessed in vitro with a test bench. The clinical study included 30 patients. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity and binocular defocus curve were evaluated 6 months postoperatively., Results: The through-focus MTFa curve for the 4.5-mm pupil size showed only one peak at distance focus (38.4 units). For the 3-mm pupil size, the through-focus MTFa showed a lower peak of MTFa (28.9 units), located at -0.70 D, and an extended depth of focus up to -2.20 D. The halo formed was larger and more intense compared to a standard monofocal IOL. The clinical outcomes at 6 months revealed satisfactory visual acuity outcomes. All patients achieved a binocular CDVA of 0.1 logMAR or better. The mean visual acuity was better than 0.2 logMAR between +1.00 and -2.00 D of defocus. At a vergence of -2.50 D, the visual acuity was 0.31 ± 0.09 logMAR., Conclusions: The AcrySof IQ Vivity IOL provided good distance optical and visual quality and an extended range of focus of approximately 2.00 D, obtaining an optimal or functional visual acuity up to 50 to 40 cm. The halo formed was low intensity overall, but higher intensity than a monofocal IOL. [ J Refract Surg . 2022;38(3):168-176.] .
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- 2022
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34. Effect of defocus combined with rotation on the optical performance of trifocal toric IOLs.
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Ruiz-Alcocer J, Martínez-Alberquilla I, Lorente-Velázquez A, Alfonso JF, and Madrid-Costa D
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- Humans, Prosthesis Design, Refraction, Ocular, Vision, Ocular, Astigmatism surgery, Lenses, Intraocular, Phacoemulsification, Refractive Errors
- Abstract
Purpose: To objectively analyze the optical quality of the FineVision Toric intraocular lens (IOL) with two cylinder powers when different combinations of rotations and residual refractive errors are induced., Methods: This study assessed the FineVision Toric IOL with two different cylinder powers: 1.5 and 3.0 diopters (D). Three different rotation positions were considered: centered, 5° and 10° rotated. An optical bench (PMTF) was used for optical analysis. The optical quality of the IOLs was calculated by the modulation transfer function (MTF) at five different focal points (0.0, 0.25, 0.50, 0.75, and 1.00 D)., Results: The MTF averaged value of the reference situation was 38.58 and 37.74 for 1.5 and 3.0 D of cylinder, respectively. For the 1.5 D cylinder, the combination of 5° of rotation with a defocus of 0.25, 0.50, 0.75, and 1.0 D induced a decrease on the MTF of 12.39, 19.94, 23.43, 24.23 units, respectively. When induced rotation was 10°, the MTF decrease was 17.26, 23.40, 24.33, 24.48 units, respectively. For the 3.0 D cylinder, the combination of 5° with 0.25, 0.50, 0.75, and 1.0 D of defocus, induced a decrease on the MTF of 12.51, 18.97, 22.36, 22.48 units, respectively. When induced rotation was 10°, the MTF decrease was: 18.42, 21.57, 23.08, and 23.61 units, respectively., Conclusion: For both FineVision Toric IOLs there is a certain optical tolerance to rotations up to 5° or residual refractive errors up to 0.25 D. Situations over these limits and their combination would affect the visual quality of patients implanted with these trifocal toric IOLs.
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- 2022
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35. A New Pre-descemetic Corneal Ring (Neoring) in Deep Anterior Lamellar Keratoplasty for Moderate-Advanced Keratoconus: A Pilot 2-Year Long-Term Follow-Up Study.
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Alfonso-Bartolozzi B, Lisa C, Fernández-Vega-Cueto L, Madrid-Costa D, and Alfonso JF
- Abstract
Purpose: To assess the outcomes of implanting a new polymethylmethacrylate (PMMA) ring (Neoring; AJL Ophthalmic) in pre-descemet deep anterior lamellar keratoplasty (PD-DALK) procedure for moderate-advanced keratoconus. Methods: This prospective study included 10 eyes of 10 patients with moderate-advanced keratoconus who underwent PD-DALK with Neoring implantation. Neoring was implanted in a pre-descemetic pocket. The post-operative examination included refraction, corrected distance visual acuity (CDVA), corneal tomography, and endothelial cell density (ECD). The root mean squares (RMSs) for coma-like aberrations and spherical aberration were evaluated for a pupil size of 4.5 mm. The junctional graft (Tg) and host (Th) thicknesses were measured. The post-operative follow-up was 24 months. Results: Post-operative CDVA was 0.82 ± 0.14 (decimal scale), 100% of the eyes achieved a CDVA of 0.7 (decimal scale). The refractive cylinder was -2.86 ± 1.65 2-years after surgery. No eyes had a post-operative refractive cylinder ≥5.00 D and in five eyes (50%), it was ≤2.50 D. At the last visit, the mean keratometry was 45.64 ± 1.96 D, the RMS for coma-like aberrations was 0.30 ± 0.15 μm and spherical aberration was 0.22 ± 0.09. The mean ECD remains without changes over the follow-up ( P = 0.07). At the last visit, Tg and Th were 679.9 ± 39.0 and 634.8 ± 41.2 μm, respectively. The thickness of the complex (host-Neoring) was 740.6 ± 35.6 μm. In all cases, this thickness was thicker than Tg. Conclusion: The results of this study suggest that PD-DALK along Neoring implantation is a viable, effective, and safe option to optimize the post-operative results for moderate-severe keratoconus., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Alfonso-Bartolozzi, Lisa, Fernández-Vega-Cueto, Madrid-Costa and Alfonso.)
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- 2021
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36. Visual function, ocular surface integrity and symptomatology of a new extended depth-of-focus and a conventional multifocal contact lens.
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Martínez-Alberquilla I, García-Montero M, Ruiz-Alcocer J, Crooke A, and Madrid-Costa D
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- Contrast Sensitivity, Humans, Tears, Visual Acuity, Contact Lenses, Hydrophilic, Presbyopia therapy
- Abstract
Purpose: To evaluate visual function, ocular surface integrity and dry eye symptoms with an extended depth-of-focus (EDOF) design and a conventional multifocal (MF) contact lens (CL) after 15 days of wear., Methods: A crossover single mask randomised clinical trial was conducted including 30 presbyopes who used an EDOF and a conventional MF CL (Biofinity MF) for 15 days each. Defocus curves, depth-of-focus range, contrast sensitivity (CS) under photopic and mesopic conditions (with and without glare) and subjective perception of halos and glare were evaluated. The ocular surface was evaluated through non-invasive Keratograph tear breakup time (NIKBUT), averaged tear breakup time (NIKBUT-avg), tear meniscus height (TMH), bulbar and limbal redness, and conjunctival and corneal staining. Dry eye symptoms were assessed with the OSDI questionnaire., Results: No statistically significant differences were found for defocus curves or depth-of-focus between the two CLs (both p > 0.05). Subjective perception of halos and glare was not significantly different between CLs. Statistically significant differences were observed for CS under mesopic conditions for low spatial frequencies (p = 0.008). None of the CL produced significant changes in NIKBUT, NIKBUT-avg, TMH or redness. No change in conjunctival staining was observed in 76.7 % and 73.3 % of participants for EDOF and Biofinity MF, respectively. No change in corneal staining was observed in 86.7 % and 83.3 % of participants for EDOF and Biofinity MF, respectively. No changes were observed in the symptomatology measured with OSDI questionnaire (p > 0.05)., Conclusions: Both CL for presbyopia offer good visual quality, preserve the ocular surface integrity and provide the patient with similar symptomatology levels after 15 days of lens wear., (Copyright © 2020 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.)
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- 2021
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37. Intrastromal corneal ring segment implantation in paracentral keratoconus with perpendicular topographic astigmatism and comatic axis.
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Fernández-Vega-Cueto L, Lisa C, Alfonso-Bartolozzi B, Madrid-Costa D, and Alfonso JF
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- Corneal Stroma surgery, Corneal Topography, Humans, Prostheses and Implants, Prosthesis Implantation, Refraction, Ocular, Retrospective Studies, Astigmatism surgery, Keratoconus surgery
- Abstract
Purpose: To evaluate the outcomes of implanting intrastromal corneal ring segment (ICRS) using two different strategies in a specific paracentral keratoconus phenotype., Methods: Eighty-nine eyes with paracentral keratoconus with perpendicular topographic astigmatism and comatic axes were evaluated before and after implanting a 150° arc-length ICRS. Patients were divided into two groups according to the axis where the ICRS was implanted: Group I: comatic axis and Group II: flat topographic axis. Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refractive errors, and root mean square (RMS) for coma-like aberration were recorded. The postoperative follow-up was 1 year., Results: Mean UDVA (logMAR) changed from 0.49 ± 0.37 preoperatively to 0.30 ± 0.32 6 months afterwards ( p < 0.001) in the group I and from 0.53 ± 0.34 to 0.37 ± 0.35 ( p < 0.001), in the group II. Mean CDVA in group I changed from 0.11 ± 0.18 preoperatively to 0.06 ± 0.14 6 months after surgery ( p < 0.001). In group II the improvement did not reach statistical significance (from 0.09 ± 0.10 to 0.07 ± 0.09; p = 0.06). No eyes lost lines of CDVA in group I. Eight eyes (15.7%) lost lines of CDVA in group II. The spherical equivalent decreased after surgery in both groups ( p < 0.001). The RMS for corneal coma-like aberration only decreased in the group I ( p < 0.001)., Conclusion: Both strategies provided safe and effective visual and refractive outcomes in the specific keratoconus phenotype analyzed. The orthopedic strategy provided better visual outcomes than the refractive one.
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- 2021
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38. Seven-year follow-up of posterior chamber phakic intraocular lens with central port design.
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Fernández-Vega-Cueto L, Alfonso-Bartolozzi B, Lisa C, Madrid-Costa D, and Alfonso JF
- Abstract
Background: To assess the clinical outcomes of the Visian Implantable Collamer Lens (ICL) with a central port throughout 7 years of follow-up., Methods: Eighty-four eyes of 52 patients were evaluated over a follow-up period of 7 years after V4c ICL implantation. Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, intraocular pressure (IOP), endothelial cell density (ECD) and vault were analysed., Results: The mean postoperative UDVA (logMAR) was 0.04 ± 0.11, 0.13 ± 0.19 and 0.17 ± 0.23 at 1-, 5- and 7-years, respectively (P < 0.0001). The mean CDVA (logMAR) remains unchanged throughout a 7-year follow-up period (0.02 ± 0.08 and 0.02 ± 0.08, at 5- and 7-years, respectively, P = 0.2). At all follow-up visits, more than 95% of the eyes achieved a CDVA of 20/25 or better and more than 85% a CDVA of 20/20. At the end of the follow-up (7 years), no eye lost more lines of CDVA, 56 eyes (66.7%) and 28 eyes (33.3%) gained lines of CDVA. At 7-years, the spherical equivalent was - 0.62 ± 0.62 D. No significant increase in IOP (> 20 mmHg or an increase higher than 5 mmHg) occurred in any case throughout the 7-year of follow-up. The loss in ECD from the preoperative baseline at the last follow-up visit was 2.6%. No intraoperative or postoperative complications or adverse events occurred during the follow-up period., Conclusions: The outcomes of this study show the long-term viability of the V4c ICL implantation as a surgical option for the correction of myopia.
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- 2021
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39. Optical tolerance to rotation of trifocal toric intraocular lenses as a function of the cylinder power.
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Ruiz-Alcocer J, Lorente-Velázquez A, de Gracia P, and Madrid-Costa D
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- Humans, Prosthesis Design, Refraction, Ocular, Vision, Ocular, Astigmatism, Lenses, Intraocular
- Abstract
Background: The aim was to assess the impact of 5- and 10-degree rotations in the optical quality of a trifocal toric intraocular lens with different amounts of cylinder., Methods: Two Physiol Toric intraocular lenses with 1.5 and 3.0 D of cylinder were analysed in three different positions: centred, 5 and 10 degrees rotated. The optical quality of the intraocular lenses was evaluated with the PMTF optical bench through specific perpendicular targets. The analysis was performed by the through-focus modulation transfer function curves and the modulation transfer function corresponding to distance vision (0 D of vergence)., Results: For a centred situation, the through-focus modulation transfer function curves of both intraocular lenses showed the classical three peaks corresponding to the powers of the two principal meridians of the intraocular lenses. When 5 and 10 degrees of rotation were induced, the three peaks were attenuated in both cases. The case with the intraocular lens with 3.0 D of cylinder and 10 degrees of rotation showed the worst optical quality and a significant loss of trifocality. The modulation transfer function values obtained for distance vision also showed the worst optical quality for the intraocular lens with 3.0 D of cylinder and 10 degrees of rotation., Conclusion: Rotations over 5 degrees decreased the optical quality of trifocal toric intraocular lenses, being this reduction moderate from 5 to 10 degrees for low levels of cylinder (≤1.5 D). For mid-high levels of cylinder (≥3.0 D), rotations over 5 degrees cause a significant loss of optical quality at all object distances.
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- 2021
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40. Visual and Tomographic Outcomes of a 300° Arc-length ICRS Implantation in Moderate to Advanced Central Keratoconus.
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Alfonso JF, Torquetti L, Fernández-Vega-Cueto L, Allan B, Poo-López A, Alfonso-Bartolozzi B, de la Cruz J, Monteiro T, and Madrid-Costa D
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- Corneal Stroma diagnostic imaging, Corneal Stroma surgery, Corneal Topography, Humans, Prostheses and Implants, Prosthesis Implantation, Refraction, Ocular, Keratoconus surgery
- Abstract
Purpose: To assess the outcomes of implanting a new 300° arc-length intrastromal corneal ring segment (ICRS) in moderate to advanced central hyperprolate keratoconus., Methods: Forty-two eyes with moderate to advanced central hyperprolate keratoconus were evaluated before and after implanting an inferior 300° ICRS (AJL Ophthalmic). The clinical measurements taken included manifest refraction, uncorrected (UDVA) and corrected (CDVA) distance visual acuity (logMAR scale), and corneal tomographic analysis (Sirius; Costruzioni Strumenti Oftalmici). Changes in the anterior and posterior corneal surfaces and the root mean square (RMS) for coma-like aberrations for a pupil size of 4.5 mm were evaluated. All examinations were performed before surgery and 6 months after surgery., Results: The mean UDVA improved from 1.12 ± 0.48 logMAR preoperatively to 0.73 ± 0.37 logMAR postoperatively ( P < .0001). The mean CDVA changed from 0.33 ± 0.20 to 0.20 ± 0.11 logMAR ( P < .0001). Postoperatively, the CDVA improved by two or more lines in 45.2% of the eyes and increased by one line in 19.04%, and none of the patients lost lines of CDVA. All of the anterior and posterior corneal tomographic parameters analyzed were significantly improved after surgery, except posterior flat keratometry, which remained unchanged. In 80.95% of the eyes, the postoperative mean keratometry was 50.00 diopters or less. The 6-month RMS for coma-like aberrations also declined significantly from 1.57 ± 0.68 to 1.06 ± 0.42 µm after surgery ( P < .0001)., Conclusions: These results suggest that implanting a 300° arc-length ICRS is a safe and effective procedure for treating patients with moderate to advanced central hyperprolate keratoconus and clear cornea. [ J Refract Surg . 2021;37(4):249-255.] .
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- 2021
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41. Impact of contact lens wear on NLRP3 gene expression: Implications for ocular frailty in middle-aged adults.
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Crooke A, Martínez-Alberquilla I, García-Montero M, Rico-Del-Viejo L, Ruiz-Alcocer J, and Madrid-Costa D
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- Aged, Frailty metabolism, Humans, Middle Aged, NLR Family, Pyrin Domain-Containing 3 Protein biosynthesis, Conjunctiva metabolism, Contact Lenses, Hydrophilic, Frail Elderly, Frailty genetics, Gene Expression Regulation, NLR Family, Pyrin Domain-Containing 3 Protein genetics
- Abstract
The inflammatory process plays a crucial role in frailty syndrome, which can appear in middle age and is associated with a poor health outcome. Consequently, gerontologists recommend screening inflammatory biomarkers in middle-aged adults to detect frailty and, therefore, prevent chronic diseases and mortality. External factors could be a risk factor for frailty because they can generate and extend the inflammatory process. For these reasons, we analysed the effect of long-term contact lens wear on mRNA level of genes linked to inflammation (IL-6, NLRP3, NK1R, CD73, MUC16 and TRPV1 genes) in conjunctival cells of middle-aged individuals, by quantitative PCR. Middle-aged contact lens wearers presented a significant increase of NLRP3 and MUC16 mRNA level as well as a decrease of CD73 mRNA level, in comparison with non-contact lens wearers. Additionally, we checked for a potential correlation between these transcript levels and clinical changes of the participants' ocular surface. Unlike molecular analysis, clinical examination fails to detect inflammation in contact lens wearers. These data suggest that long-term contact lens wear could trigger an inflammatory response in middle age orchestrated by NLRP3 inflammasome and modulated by CD73 and MUC16 proteins. Further studies are needed to confirm our gene expression findings at the protein level as well as to investigate the potential role of long-term CL wear in the onset of ocular frailty., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
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- 2021
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42. Comparison of clinical outcomes between manual and femtosecond laser techniques for intrastromal corneal ring segment implantation.
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Monteiro T, Alfonso JF, Franqueira N, Faria-Correira F, Ambrósio R Jr, and Madrid-Costa D
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- Adult, Corneal Stroma pathology, Corneal Stroma surgery, Female, Humans, Keratoconus diagnosis, Keratoconus physiopathology, Male, Middle Aged, Visual Acuity, Young Adult, Corneal Topography methods, Keratoconus surgery, Laser Therapy methods, Ophthalmologic Surgical Procedures methods, Prostheses and Implants, Prosthesis Implantation methods, Refraction, Ocular
- Abstract
Purpose: The purpose was to compare the visual, refractive and aberrometric results of intrastromal corneal ring segments implantation with manual dissection and femtosecond laser-assisted surgery., Methods: This is a multicentre study, which included consecutive patients with paracentral keratoconus, in which the difference between the axes of the topographic flattest and the coma aberration was <60°, who had Ferrara-type intrastromal corneal ring segment implantation using manual dissection or femtosecond laser technique. LogMAR uncorrected (uncorrected distance visual acuity) and corrected (corrected distance visual acuity) distance visual acuity, refractive errors and the root mean square for corneal coma-like aberration were recorded before and at 6 months after surgery., Results: The study included 84 and 110 eyes in the manual group and in the femtosecond group, respectively. After surgery, there was a statistically significant improvement in uncorrected distance visual acuity and corrected distance visual acuity for both groups ( p < 0.0001), and there were no statistically significant differences between groups ( p > 0.3). For both groups, there was a reduction in spherical equivalent after intrastromal corneal ring segment implantation ( p < 0.0001). There were no statistically significant differences between groups in the magnitude of spherical equivalent reduction ( p = 0.34) The magnitude of the root mean square coma-like reduction was 0.93 ± 0.76 and 0.83 ± 0.80 μm in the manual and femtosecond group, respectively ( p = 0.2). While in the femtosecond laser group no complications were reported, in the manual group, the intraoperative or postoperative complications rate was 13.09%., Conclusion: Although both surgical techniques provide comparable visual, refractive and aberrometric outcomes, it should be noted that the femtosecond laser is a safer surgical procedure, with no complications reported.
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- 2020
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43. Optical Performance of a Trifocal IOL and a Novel Extended Depth of Focus IOL Combined With Different Corneal Profiles.
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Ruiz-Alcocer J, Lorente-Velázquez A, Hernández-Verdejo JL, De Gracia P, and Madrid-Costa D
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- Humans, Myopia physiopathology, Prosthesis Design, Cornea diagnostic imaging, Models, Theoretical, Multifocal Intraocular Lenses, Myopia surgery, Optics and Photonics, Refraction, Ocular physiology
- Abstract
Purpose: To assess the effect of prior myopic ablations on the optical performance of a trifocal diffractive intraocular lens (IOL) and a novel extended depth of focus (EDOF) diffractive design., Methods: The novel XACT Mono-EDOF ME4 diffractive IOL (Santen Pharmaceutical) and the trifocal diffractive FineVision IOL (PhysIOL) were analyzed standing alone and combined with a simulated myopic corneal ablation. The optical quality of the IOLs in both situations was evaluated with the PMTF optical bench (LAMBDA-X). The through-focus modulation transfer function (MTF) curves and the MTF at three different focal points (+0.50, 0.00, and -0.50 diopters [D]) were recorded., Results: The through-focus MTF curves showed three differentiated peaks for the trifocal IOL and two overlapped peaks for the EDOF IOL. The presence of simulated myopic corneal ablations induces a -0.50 D shift on the overall through-focus curves and softens the multifocal properties of both lenses by decreasing the variations through focus of the MTF. For the analysis of the lenses standing alone, the highest MTF values were obtained for an object vergence of 0.00 D. For a simulated myopic corneal ablation, both IOLs showed better optical quality results at -0.50 D., Conclusions: The trifocal IOL provides better optical quality at far and near distances when analyzed alone. The EDOF IOL optical properties are more stable when a myopic ablation is introduced. Preoperative calculations of both lenses should consider that prior myopic corneal ablations induce a -0.50 D shift on their far peak quality. [J Refract Surg. 2020;36(7):435-441.]., (Copyright 2020, SLACK Incorporated.)
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- 2020
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44. Three-year follow-up of intrastromal corneal ring segment implantation in central keratoconus with regular astigmatism: 'Bow-tie' shape.
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Fernández-Vega-Cueto L, Lisa C, Poo-López A, Alfonso JF, and Madrid-Costa D
- Subjects
- Adult, Corneal Pachymetry, Corneal Topography, Female, Follow-Up Studies, Humans, Keratoconus physiopathology, Male, Middle Aged, Postoperative Period, Prostheses and Implants, Refraction, Ocular physiology, Refractive Errors physiopathology, Visual Acuity physiology, Young Adult, Astigmatism surgery, Corneal Stroma surgery, Keratoconus surgery, Prosthesis Implantation
- Abstract
Purpose: To assess the outcomes of implanting Ferrara-type intrastromal corneal ring segments in central 'bow-tie'-shaped keratoconus over 3 years of follow-up., Methods: A total of 20 eyes with central 'bow-tie'-shaped keratoconus were evaluated before and after implanting Ferrara-type intrastromal corneal ring segments (AJL Ophthalmic, Spain). LogMAR uncorrected distance visual acuity and best corrected distance visual acuity and residual refractive errors analysed using vector analysis were recorded preoperatively, at 6 months, 1 year, and 3 years postoperatively., Results: The mean uncorrected distance visual acuity (LogMAR scale) rose from a preoperative 0.75 ± 0.28 to a 6-month postoperative 0.38 ± 0.28 (p < 0.0001). The corrected distance visual acuity, in turn, improved from 0.07 ± 0.06 to 0.05 ± 0.06 (p = 0.0008). Both the uncorrected distance visual acuity and corrected distance visual acuity were stable over the postoperative period in both groups (p > 0.05). None of the eyes lost uncorrected distance visual acuity and corrected distance visual acuity lines over the postoperative follow-up period. The spherical equivalent and the refractive cylinder declined steeply after intrastromal corneal ring segments implantation (p < 0.0001). Both the spherical equivalent and refractive cylinder were stable over the postoperative period. None of the eyes had an increase in maximum or minimum keratometry greater than 0.75D over the postoperative period., Conclusion: The planning for intrastromal corneal ring segments insertion proposed in this study reduces the spherical equivalent and refractive cylinder in this type of keratoconus, while improving post-surgery uncorrected distance visual acuity and corrected distance visual acuity. These results remain stable over 3 years of follow-up. Therefore, this procedure could be considered as an effective therapeutic alternative in patients affected by this type of keratoconus.
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- 2020
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45. FemtoLASIK After Descemet Membrane Endothelial Keratoplasty.
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Fernández-Vega-Cueto L, Lisa C, Naveiras M, Madrid-Costa D, and Alfonso JF
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- Aged, Corneal Topography methods, Female, Follow-Up Studies, Fuchs' Endothelial Dystrophy diagnosis, Humans, Male, Middle Aged, Postoperative Complications diagnosis, Refractive Errors etiology, Refractive Errors physiopathology, Tomography, Optical Coherence methods, Treatment Outcome, Descemet Stripping Endothelial Keratoplasty methods, Fuchs' Endothelial Dystrophy surgery, Keratomileusis, Laser In Situ methods, Postoperative Complications surgery, Refraction, Ocular physiology, Refractive Errors therapy, Visual Acuity
- Abstract
Purpose: To evaluate the efficacy and safety of femtosecond laser-assisted in situ keratomileusis (FemtoLASIK) to correct the residual refractive error after Descemet membrane endothelial keratoplasty (DMEK)., Methods: This case series study included 7 eyes that underwent FemtoLASIK after a DMEK surgery. The refractive error, uncorrected (UDVA) and corrected (CDVA) distance visual acuities, corneal topography (Sirius, CSO, Italy), and anterior segment optical coherence tomography (Visante, Carl Zeiss-Meditec AG, Jena, Germany) were registered at each postoperative follow-up visit., Results: All surgeries were uneventful, with no intraoperative or postoperative complications. The follow-up time after DMEK (before FemtoLASIK surgery) ranged from 18 to 36 months. The post-FemtoLASIK follow-up period ranged from 12 to 60 months. All cases experienced a significant improvement in UDVA after FemtoLASIK, all of them reaching a postoperative UDVA value ≥20/32. None of the eyes lost lines of CDVA, and 1 case showed a gain of lines of CDVA. In all cases, the refractive error, UDVA, and CDVA values remained stable at their respective postoperative follow-up visits. Furthermore, all topographic and pachymetric parameters were stable at the different postoperative follow-up visits., Conclusions: Our findings suggest that the residual refractive error after DMEK surgery can be safely and effectively treated with FemtoLASIK.
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- 2020
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46. Dry Eye Disease and Refractive Corrections.
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Madrid-Costa D, Wolffsohn JS, Ruiz-Alcocer J, and De Gracia P
- Abstract
Competing Interests: The authors declare that they have no conflicts of interest. David Madrid-Costa James S. Wolffsohn Javier Ruiz-Alcocer Pablo De Gracia
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- 2019
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47. Meibomian Gland Morphology: The Influence of Structural Variations on Gland Function and Ocular Surface Parameters.
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Llorens-Quintana C, Rico-Del-Viejo L, Syga P, Madrid-Costa D, and Iskander DR
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Osmolar Concentration, Surveys and Questionnaires, Tears chemistry, Young Adult, Meibomian Glands anatomy & histology, Meibomian Glands physiology
- Abstract
Purpose: To objectively and quantitatively characterize meibomian gland morphology and to investigate the influence of morphological variations on gland function and ocular surface and tear film parameters., Methods: One hundred fifty subjects were enrolled. The examinations included tear osmolarity, tear meniscus height, bulbar conjunctival hyperemia, noninvasive tear film breakup time, lid margin thickness, foam secretion, meibomian gland expressibility, count of functioning glands, corneal and conjunctival staining, fluorescein breakup time, lid wiper epitheliopathy, and Schirmer test. Patient symptoms were assessed using the Ocular Surface Disease Index questionnaire. Images from noncontact meibography were analyzed using an automated method that objectively estimates dropout area, number of glands, gland length and width, and gland irregularity., Results: Gland irregularity highly correlated with dropout area (r = -0.4, P < 0.001) and showed significant partial correlations with fluorescein breakup time (r = 0.162, P = 0.049) and the Ocular Surface Disease Index questionnaire (r = -0.250, P = 0.002) Subjects with dropout area <32% were divided into 2 groups: high and low irregularity. Gland expressibility was statistically significantly different between the 2 groups (U = 319.5, P = 0.006). In the high irregularity group, gland irregularity correlated with the Schirmer test (r = 0.530, P = 0.001) and corneal fluorescein staining (r = -0.377, P = 0.021)., Conclusions: Automated morphological analysis of meibomian gland structure provides additional quantitative and objective information regarding gland morphology. The link between dropout area and gland function is not clear. Assessment of gland irregularity might better predict gland function and its effects on ocular surface and tear film parameters.
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- 2019
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48. Comparison of Complication Rates between Manual and Femtosecond Laser-Assisted Techniques for Intrastromal Corneal Ring Segments Implantation in Keratoconus.
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Monteiro T, Alfonso JF, Freitas R, Franqueira N, Faria-Correira F, Ambrósio R, and Madrid-Costa D
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- Adult, Corneal Stroma pathology, Corneal Topography, Female, Follow-Up Studies, Humans, Male, Ophthalmologic Surgical Procedures methods, Portugal epidemiology, Refraction, Ocular physiology, Retrospective Studies, Visual Acuity, Corneal Stroma surgery, Keratoconus surgery, Laser Therapy adverse effects, Ophthalmologic Surgical Procedures adverse effects, Postoperative Complications epidemiology, Prostheses and Implants, Prosthesis Implantation adverse effects
- Abstract
Purpose : To compare the incidence of complications between manual and femtosecond-laser assisted surgery for intrastromal corneal ring segments (ICRS) implantation. Material and methods : This study included keratoconus patients who had ICRS implantation using manual dissection and using the femtosecond laser with a minimum follow-up of 12 months. Uncorrected (UDVA) corrected (CDVA) distance visual acuity (CDVA), refraction, corneal topography and aberrometry, pachymetry map and slit-lamp microscopy were assessed before and after surgery. Results : The study included 265 eyes in the manual group and 111 in the femtosecond laser group. In the manual group, there were complications in 48 eyes (18.11%); while in the femtosecond laser 4 eyes had a complication (3.6%). In the manual group, the most frequent complications were ICRS exchange/adjustment for visual and refractive enhancement (25 eyes; 9.43%) and late ICRS spontaneous extrusion (15 eyes; 5.66%). In the manual group, 81.25% of complications were observed during the first 3 years of surgeon's experience. Eyes who suffered a complication had preoperatively higher mean refractive ( p = .002) and topographic cylinder ( p = .003) and lower UDVA ( p = .005) and CDVA ( p = .002). After a second surgical procedure for complication management visual, refractive and topographic outcomes significantly improved. Conclusion : Manual mechanical ICRS surgery shows a higher rate of intra- and postoperative mechanical and refractive complications when compared to femtosecond laser assisted technique. The incidence is specially higher during the surgeon's first years of implementation of the technique.
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- 2019
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49. Repeatability of Noninvasive Keratograph 5M Measurements Associated With Contact Lens Wear.
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García-Montero M, Rico-Del-Viejo L, Lorente-Velázquez A, Martínez-Alberquilla I, Hernández-Verdejo JL, and Madrid-Costa D
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- Adult, Female, Humans, Hyperemia physiopathology, Male, Myopia physiopathology, Prospective Studies, Prosthesis Fitting, Reproducibility of Results, Tears chemistry, Young Adult, Contact Lenses, Hydrophilic, Cornea physiopathology, Corneal Topography instrumentation, Myopia therapy, Tears physiology
- Abstract
Objective: To assess the intrarater repeatability of the measurements of tear meniscus height (TMH), noninvasive keratograph tear break-up time (NIKBUTs), and ocular redness measurements obtained with the Keratograph 5M (K5M) in a sample of soft silicone hydrogel contact lens (CL) wearers over 15 days., Methods: Prospective study over two consecutive weeks. Three measurements of TMH, NIKBUTs (NIKBUT first and NIKBUT average), and ocular redness were obtained in different sessions; the first day (baseline, at 8 hr of wear, and after lens removal) and the last day of wear-15th day (at 8 hr of wear and after lens removal). The repeatability of measurements were assessed by two intraclass correlation coefficient (ICC) forms; single measurement [ICC (2,1)] and multiple measurements (k=3) [ICC (2, k)]., Results: Sixty-four eyes were analyzed. The repeatability of baseline TMH [ICC (2,1) greater than 0.90; coefficient of repeatability (CR)=0.06 mm] and after and during CL wear [ICC (2,k) greater than 0.90; CR≤0.07 mm] were excellent. The repeatability of baseline NIKBUT average [ICC (2,k)=0.89 (0.82-0.93); CR=6.07 sec] was maintained after CL removal but was poorer during CL wear. The repeatability of baseline NIKBUT first [ICC (2,k) =0.80 (0.69-0.87); CR=8.74 sec] was maintained after CL removal and during CL wear at moderate-good level., Conclusions: Intrarater repeatability of TMH, NIKBUTs, and ocular redness performed by K5M after CL wear remains stable when three measurements are performed. However, intrarater repeatability during CL wear decreased only for NIKBUT average and was not affected by time of use (15 days).
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- 2019
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50. The influence of meibomian gland loss on ocular surface clinical parameters.
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Rico-Del-Viejo L, Benítez-Del-Castillo JM, Gómez-Sanz FJ, García-Montero M, Llorens-Quintana C, and Madrid-Costa D
- Subjects
- Adult, Age Factors, Aged, Aged, 80 and over, Female, Humans, Male, Meibomian Gland Dysfunction diagnostic imaging, Middle Aged, Osmolar Concentration, Slit Lamp Microscopy, Staining and Labeling, Surveys and Questionnaires, Tears chemistry, Young Adult, Conjunctiva physiopathology, Cornea physiopathology, Dry Eye Syndromes physiopathology, Meibomian Gland Dysfunction physiopathology
- Abstract
Purpose: To assess the relationship between the meibomian gland loss (MGL) and relevant ocular surface clinical parameters as well as the influence of age in this relationship., Methods: A total of 161 participants (mean age; 42±17 years) were enrolled in this study. Infrared meibography was performed using Keratograph 5M (K5M; Oculus GmbH, Wetzlar). Participants were divided into five groups according to total meiboscore and the ocular surface parameters of each MGL group were studied. In addition, the relationship between MGL and the ocular surface parameters was established including age as covariant., Results: Both eyelids were taken into account since no association between the MGL from upper and lower eyelid was found (k value=0.2; p=0.3) despite they were significantly correlated (r= 0.3; p<0.001). No statistically significant differences were found in symptomatology among different MGL groups. Statistically significant differences were found among MGL groups in tear osmolarity (p=0.02), bulbar redness (p=0.04), corneal and conjunctival staining (p=0.01 and p=0.004, respectively). Despite this, only corneal staining showed a significant correlation with MGL when age was covariant (r=0.2; p=0.04)., Conclusions: MGL higher than 50% seems to be accompanied by signs on the ocular surface. Furthermore, age demonstrated to be a relevant factor when assessing MGL. For this reason, future studies should compare age-matched groups in order to know the contribution of the MGL on the ocular surface and establish valid cut-off values for dry eye diagnosis., (Copyright © 2019 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2019
- Full Text
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