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1. Late boosting of the RV144 regimen with AIDSVAX B/E and ALVAC-HIV in HIV-uninfected Thai volunteers: a double-blind, randomised controlled trial

Author

Pitisuthitham, Arom, Sabmee, Yupa, Sirisopana, Narongrid, Eamsila, Chirapa, Savaraj, Prapaporn, Labwech, Wanlaya, Teerachia, Siriluck, Chotirosniramit, Nuntisa, Supindham, Taweewat, Pruenglampoo, Boonlure, Sugandhavesa, Patcharaphan, Kosashunhanan, Natthapol, Kaewthip, Oranitcha, Sroysuwan, Piyathida, Jarujareet, Pawinee, Ratto-Kim, Silvia, Molnar, Sebastian, Schoen, Jesse, Churikanont, Nampueng, Getchalarat, Saowanit, Sangnoi, Nongluck, Nuntapinit, Bessara, Phramtong, Anant, Grandin, Pornsuk V., Madnote, Sirinan, Rittiroongrad, Surawach, Kaewboon, Boot, Trichavaroj, Rapee, Puangkaew, Jiraporn, Chantakulkij, Somsak, Rakyat, Phiromrat, Panjapornsuk, Pornchanok, Tragonlugsana, Nipattra, Chuenarom, Weerawan, de Souza, Mark, Ngauy, Viseth, Phanuphak, Nittaya, Chomchey, Nitiya, Saengtawan, Puttachard, Teeratakulpisarn, Nipat, Rerknimitr, Rungsun, Kroon, Eugene, Lee, Carter A., Chinaworapong, Suchada, Pitisuttithum, Punnee, Nitayaphan, Sorachai, Chariyalertsak, Suwat, Kaewkungwal, Jaranit, Dawson, Peter, Dhitavat, Jittima, Phonrat, Benjaluck, Akapirat, Siriwat, Karasavvas, Nicos, Wieczorek, Lindsay, Polonis, Victoria, Eller, Michael A, Pegu, Poonam, Kim, Dohoon, Schuetz, Alexandra, Jongrakthaitae, Surat, Zhou, Yingjun, Sinangil, Faruk, Phogat, Sanjay, Diazgranados, Carlos A, Tartaglia, James, Heger, Elizabeth, Smith, Kirsten, Michael, Nelson L, Excler, Jean-Louis, Robb, Merlin L, Kim, Jerome H, O'Connell, Robert J, and Vasan, Sandhya

Published
2020
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2. Late boosting of the RV144 regimen with AIDSVAX B/E and ALVAC-HIV in HIV-uninfected Thai volunteers: a double-blind, randomised controlled trial

Author

Pitisuttithum, Punnee, primary, Nitayaphan, Sorachai, additional, Chariyalertsak, Suwat, additional, Kaewkungwal, Jaranit, additional, Dawson, Peter, additional, Dhitavat, Jittima, additional, Phonrat, Benjaluck, additional, Akapirat, Siriwat, additional, Karasavvas, Nicos, additional, Wieczorek, Lindsay, additional, Polonis, Victoria, additional, Eller, Michael A, additional, Pegu, Poonam, additional, Kim, Dohoon, additional, Schuetz, Alexandra, additional, Jongrakthaitae, Surat, additional, Zhou, Yingjun, additional, Sinangil, Faruk, additional, Phogat, Sanjay, additional, Diazgranados, Carlos A, additional, Tartaglia, James, additional, Heger, Elizabeth, additional, Smith, Kirsten, additional, Michael, Nelson L, additional, Excler, Jean-Louis, additional, Robb, Merlin L, additional, Kim, Jerome H, additional, O'Connell, Robert J, additional, Vasan, Sandhya, additional, Pitisuthitham, Arom, additional, Sabmee, Yupa, additional, Sirisopana, Narongrid, additional, Eamsila, Chirapa, additional, Savaraj, Prapaporn, additional, Labwech, Wanlaya, additional, Teerachia, Siriluck, additional, Chotirosniramit, Nuntisa, additional, Supindham, Taweewat, additional, Pruenglampoo, Boonlure, additional, Sugandhavesa, Patcharaphan, additional, Kosashunhanan, Natthapol, additional, Kaewthip, Oranitcha, additional, Sroysuwan, Piyathida, additional, Jarujareet, Pawinee, additional, Ratto-Kim, Silvia, additional, Molnar, Sebastian, additional, Schoen, Jesse, additional, Churikanont, Nampueng, additional, Getchalarat, Saowanit, additional, Sangnoi, Nongluck, additional, Nuntapinit, Bessara, additional, Phramtong, Anant, additional, Grandin, Pornsuk V., additional, Madnote, Sirinan, additional, Rittiroongrad, Surawach, additional, Kaewboon, Boot, additional, Trichavaroj, Rapee, additional, Puangkaew, Jiraporn, additional, Chantakulkij, Somsak, additional, Rakyat, Phiromrat, additional, Panjapornsuk, Pornchanok, additional, Tragonlugsana, Nipattra, additional, Chuenarom, Weerawan, additional, de Souza, Mark, additional, Ngauy, Viseth, additional, Phanuphak, Nittaya, additional, Chomchey, Nitiya, additional, Saengtawan, Puttachard, additional, Teeratakulpisarn, Nipat, additional, Rerknimitr, Rungsun, additional, Kroon, Eugene, additional, Lee, Carter A., additional, and Chinaworapong, Suchada, additional

Published
2020
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3. Comparison of Antibody Responses Induced by RV144, VAX003, and VAX004 Vaccination Regimens

Author

Karnasuta, Chitraporn, primary, Akapirat, Siriwat, additional, Madnote, Sirinan, additional, Savadsuk, Hathairat, additional, Puangkaew, Jiraporn, additional, Rittiroongrad, Surawach, additional, Rerks-Ngarm, Supachai, additional, Nitayaphan, Sorachai, additional, Pitisuttithum, Punnee, additional, Kaewkungwal, Jaranit, additional, Tartaglia, James, additional, Sinangil, Faruk, additional, Francis, Donald P., additional, Robb, Merlin L., additional, de Souza, Mark S., additional, Michael, Nelson L., additional, Excler, Jean-Louis, additional, Kim, Jerome H., additional, O'Connell, Robert J., additional, and Karasavvas, Nicos, additional

Published
2017
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4. Characterization of HIV-1 gp120 antibody specificities induced in anogenital secretions of RV144 vaccine recipients after late boost immunizations.

Author

Akapirat, Siriwat, Karnasuta, Chitraporn, Vasan, Sandhya, Rerks-Ngarm, Supachai, Pitisuttithum, Punnee, Madnote, Sirinan, Savadsuk, Hathairat, Rittiroongrad, Surawach, Puangkaew, Jiraporn, Phogat, Sanjay, Tartaglia, James, Sinangil, Faruk, de Souza, Mark S., Excler, Jean-Louis, Kim, Jerome H., Robb, Merlin L., Michael, Nelson L., Ngauy, Viseth, O'Connell, Robert J., and Karasavvas, Nicos

Subjects
ANTIBODY specificity, IMMUNOSPECIFICITY, IMMUNIZATION, VACCINATION, COMMUNICABLE diseases
Abstract

Sexual transmission is the principal driver of the human immunodeficiency virus (HIV) pandemic. Understanding HIV vaccine-induced immune responses at mucosal surfaces can generate hypotheses regarding mechanisms of protection, and may influence vaccine development. The RV144 (ClinicalTrials.gov NCT00223080) efficacy trial showed protection against HIV infections but mucosal samples were not collected, therefore, the contribution of mucosal antibodies to preventing HIV-1 acquisition is unknown. Here, we report the generation, magnitude and persistence of antibody responses to recombinant gp120 envelope and antigens including variable one and two loop scaffold antigens (gp70V1V2) previously shown to correlate with risk in RV144. We evaluated antibody responses to gp120 A244gD and gp70V1V2 92TH023 (both CRF01_AE) and Case A2 (subtype B) in cervico-vaginal mucus (CVM), seminal plasma (SP) and rectal secretions (RS) from HIV-uninfected RV144 vaccine recipients, who were randomized to receive two late boosts of ALVAC-HIV/AIDSVAX®B/E, AIDSVAX®B/E, or ALVAC-HIV alone at 0 and 6 months. Late vaccine boosting increased IgG geometric mean titers (GMT) to gp120 A244gD in AIDSVAX®B/E and ALVAC-HIV/AIDSVAX®B/E CVM (28 and 17 fold, respectively), followed by SP and RS. IgG to gp70V1V2 92TH023 increased in AIDSVAX®B/E and ALVAC-HIV/AIDSVAX®B/E CVM (11–17 fold) and SP (2 fold) two weeks post first boost. IgG to Case A2 was only detected in AIDSVAX®B/E and ALVAC-HIV/AIDSVAX®B/E CVM. Mucosal IgG to gp120 A244gD (CVM, SP, RS), gp70V1V2 92TH023 (CVM, SP), and Case A2 (CVM) correlated with plasma IgG levels (p<0.001). Although the magnitude of IgG responses declined after boosting, anti-gp120 A244gD IgG responses in CVM persisted for 12 months post final vaccination. Further studies in localization, persistence and magnitude of envelope specific antibodies (IgG and dimeric IgA) in anogenital secretions will help determine their role in preventing mucosal HIV acquisition. [ABSTRACT FROM AUTHOR]

Published
2018
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5. Identification of Immunodominant CD4-Restricted Epitopes Co-Located with Antibody Binding Sites in Individuals Vaccinated with ALVAC-HIV and AIDSVAX B/E

Author

Ratto-Kim, Silvia, primary, de Souza, Mark S., additional, Currier, Jeffrey R., additional, Karasavvas, Nicos, additional, Sidney, John, additional, Rolland, Morgane, additional, Valencia-Micolta, Anais, additional, Madnote, Sirinan, additional, Sette, Alessandro, additional, Nitayaphan, Sorachai, additional, Pitisuttuthum, Punnee, additional, Kaewkungwal, Jaranit, additional, Rerks-Ngarm, Supachai, additional, O’Connell, Robert, additional, Michael, Nelson, additional, Robb, Merlin L., additional, Marovich, Mary, additional, and Kim, Jerome H., additional

Published
2015
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6. IgG Antibody Responses to Recombinant gp120 Proteins, gp70V1/V2 Scaffolds, and a CyclicV2 Peptide in Thai Phase I/II Vaccine Trials Using Different Vaccine Regimens.

Author

Karasavvas, Nicos, Karnasuta, Chitraporn, Savadsuk, Hathairat, Madnote, Sirinan, Inthawong, Dutsadee, Chantakulkij, Somsak, Rittiroongrad, Surawach, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Thongcharoen, Prasert, Siriyanon, Vinai, Andrews, Charla A., Barnett, Susan W., Tartaglia, James, Sinangil, Faruk, Francis, Donald P., Robb, Merlin L., Michael, Nelson L., Ngauy, Viseth, and de Souza, Mark S.

Abstract

RV144 correlates of risk analysis showed that IgG antibodies to gp70V1V2 scaffolds inversely correlated with risk of HIV acquisition. We investigated IgG antibody responses in RV135 and RV132, two ALVAC-HIV prime-boost vaccine trials conducted in Thailand prior to RV144. Both trials used ALVAC-HIV (vCP1521) at 0, 1, 3, and 6 months and HIV-1 gp120MNgD and gp120A244gD in alum (RV135) or gp120SF2 and gp120CM235 in MF59 (RV132) at 3 and 6 months. We assessed ELISA binding antibodies to the envelope proteins (Env) 92TH023, A244gD and MNgD, cyclicV2, and gp70V1V2 CaseA2 (subtype B) and 92TH023 (subtype CRF01_AE), and Env-specific IgG1 and IgG3. Antibody responses to gp120 A244gD, MNgD, and gp70V1V2 92TH023 scaffold were significantly higher in RV135 than in RV132. Antibodies to gp70V1V2 CaseA2 were detected only in RV135 vaccine recipients and IgG1 and IgG3 antibody responses to A244gD were significantly higher in RV135. IgG binding to gp70V1V2 CaseA2 and CRF01_AE scaffolds was higher with the AIDSVAX®B/E boost but both trials showed similar rates of antibody decline post-vaccination. MF59 did not result in higher IgG antibody responses compared to alum with the antigens tested. However, notable differences in the structure of the recombinant proteins and dosage used for immunizations may have contributed to the magnitude and specificity of IgG induced by the two trials. [ABSTRACT FROM AUTHOR]

Published
2015
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7. The Thai Phase III HIV Type 1 Vaccine Trial (RV144) Regimen Induces Antibodies That Target Conserved Regions Within the V2 Loop of gp120

Author

Karasavvas, Nicos, primary, Billings, Erik, additional, Rao, Mangala, additional, Williams, Constance, additional, Zolla-Pazner, Susan, additional, Bailer, Robert T., additional, Koup, Richard A., additional, Madnote, Sirinan, additional, Arworn, Duangnapa, additional, Shen, Xiaoying, additional, Tomaras, Georgia D., additional, Currier, Jeffrey R., additional, Jiang, Mike, additional, Magaret, Craig, additional, Andrews, Charla, additional, Gottardo, Raphael, additional, Gilbert, Peter, additional, Cardozo, Timothy J., additional, Rerks-Ngarm, Supachai, additional, Nitayaphan, Sorachai, additional, Pitisuttithum, Punnee, additional, Kaewkungwal, Jaranit, additional, Paris, Robert, additional, Greene, Kelli, additional, Gao, Hongmei, additional, Gurunathan, Sanjay, additional, Tartaglia, Jim, additional, Sinangil, Faruk, additional, Korber, Bette T., additional, Montefiori, David C., additional, Mascola, John R., additional, Robb, Merlin L., additional, Haynes, Barton F., additional, Ngauy, Viseth, additional, Michael, Nelson L., additional, Kim, Jerome H., additional, and de Souza, for the MOPH TAVEG Collab, Mark S., additional

Published
2012
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8. HIV-specific Antibody in Rectal Secretions Following Late Boosts in RV144 Participants (RV305).

Author

Karnasuta, Chitraporn, Madnote, Sirinan, Savadsuk, Hathairat, Puangkaew, Jiraporn, Rittiroongrad, Surawach, Vasan, Sandhya, Ngauy, Viseth, Robb, Merlin L., Excler, Jean-Louis, Pitisutthithum, Punnee, Rerks-Ngarm, Supachai, Michael, Nelson L., de Souza, Mark S., Kim, Jerome H., O'Connell, Robert J., and Karasavvas, Nicos

Abstract

An abstract of the article "HIV-specific Antibody in Rectal Secretions Following Late Boosts in RV144 Participants (RV305)" by Siriwat Akapirat, Chitraporn Karnasuta, Sirinan Madnote and colleagues is presented.

Published
2014
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