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1. The Cystic Fibrosis Learning Network: A mixed methods evaluation of program goals, attributes, and impact

Author

Aricca D. Van Citters, Madge E. Buus‐Frank, Joel R. King, Michael Seid, Megan M. Holthoff, Raouf S. Amin, Maria T. Britto, Eugene C. Nelson, Bruce C. Marshall, and Kathryn A. Sabadosa

Subjects
coproduction, learning networks, mixed methods evaluation, quality improvement, Medicine (General), R5-920, Public aspects of medicine, RA1-1270
Abstract

Abstract Introduction The Cystic Fibrosis (CF) Foundation sponsored the design, pilot testing, and implementation of the CF Learning Network (CFLN) to explore how the Foundation's Care Center Network (CCN) could become a learning health system. Six years after the design, the Foundation commissioned a formative mixed methods evaluation of the CFLN to assess: CFLN participants' understanding of program goals, attributes, and perceptions of current and future impact. Methods We performed semi‐structured interviews with CFLN participants to identify perceived goals, attributes, and impact of the network. Following thematic analyses, we developed and distributed a survey to CFLN members and a matched sample of CCN programs to understand whether the themes were unique to the CFLN. Results Interviews with 24 CFLN participants were conducted. Interviewees identified the primary CFLN goal as improving outcomes for people living with CF, with secondary goals of providing training in quality improvement (QI), creating a learning community, engaging all stakeholders in improvement, and spreading best practices to the CCN. Project management, use of data, common QI methods, and the learning community were seen as critical to success. Survey responses were collected from 103 CFLN members and 25 CCN members. The data revealed that CFLN respondents were more likely than CCN respondents to connect with other CF programs, routinely use data for QI, and engage patient and family partners in QI. Conclusions Our study suggests that the CFLN provides value beyond that achieved by the CCN. Key questions remain about whether spread of the CFLN could improve outcomes for more people living with CF.

Published
2023
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2. Prospects for Fundamental Physics with LISA

Author

Barausse, Enrico, Berti, Emanuele, Hertog, Thomas, Hughes, Scott A., Jetzer, Philippe, Pani, Paolo, Sotiriou, Thomas P., Tamanini, Nicola, Witek, Helvi, Yagi, Kent, Yunes, Nicolas, Abdelsalhin, T., Achucarro, A., Aelst, K. V., Afshordi, N., Akcay, S., Annulli, L., Arun, K. G., Ayuso, I., Baibhav, V., Baker, T., Bantilan, H., Barreiro, T., Barrera-Hinojosa, C., Bartolo, N., Baumann, D., Belgacem, E., Bellini, E., Bellomo, N., Ben-Dayan, I., Bena, I., Benkel, R., Bergshoefs, E., Bernard, L., Bernuzzi, S., Bertacca, D., Besancon, M., Beutler, F., Beyer, F., Bhagwat, S., Bicak, J., Biondini, S., Bize, S., Blas, D., Boehmer, C., Boller, K., Bonga, B., Bonvin, C., Bosso, P., Bozzola, G., Brax, P., Breitbach, M., Brito, R., Bruni, M., Brügmann, B., Bulten, H., Buonanno, A., Burke, A. O., Burko, L. M., Burrage, C., Cabral, F., Calcagni, G., Caprini, C., Cárdenas-Avendaño, A., Celoria, M., Chatziioannou, K., Chernoff, D., Clough, K., Coates, A., Comelli, D., Compère, G., Croon, D., Cruces, D., Cusin, G., Dalang, C., Danielsson, U., Das, S., Datta, S., de Boer, J., De Luca, V., De Rham, C., Desjacques, V., Destounis, K., Di Filippo, F., Dima, A., Dimastrogiovanni, E., Dolan, S., Doneva, D., Duque, F., Durrer, R., East, W., Easther, R., Elley, M., Ellis, J. R., Emparan, R., Ezquiaga, J. M., Fairbairn, M., Fairhurst, S., Farmer, H. F., Fasiello, M. R., Ferrari, V., Ferreira, P. G., Ficarra, G., Figueras, P., Fisenko, S., Foffa, S., Franchini, N., Franciolini, G., Fransen, K., Frauendiener, J., Frusciante, N., Fujita, R., Gair, J., Ganz, A., Garcia, P., Garcia-Bellido, J., Garriga, J., Geiger, R., Geng, C., Gergely, L. Á., Germani, C., Gerosa, D., Giddings, S. B., Gourgoulhon, E., Grandclement, P., Graziani, L., Gualtieri, L., Haggard, D., Haino, S., Halburd, R., Han, W. -B., Hawken, A. J., Hees, A., Heng, I. S., Hennig, J., Herdeiro, C., Hervik, S., Holten, J. v., Hoyle, C. J. D., Hu, Y., Hull, M., Ikeda, T., Isi, M., Jenkins, A., Julié, F., Kajfasz, E., Kalaghatgi, C., Kaloper, N., Kamionkowski, M., Karas, V., Kastha, S., Keresztes, Z., Kidder, L., Kimpson, T., Klein, A., Klioner, S., Kokkotas, K., Kolesova, H., Kolkowitz, S., Kopp, J., Koyama, K., Krishnendu, N. V., Kroon, J. A. V., Kunz, M., Lahav, O., Landragin, A., Lang, R. N., Poncin-Lafitte, C. Le, Lemos, J., Li, B., Liberati, S., Liguori, M., Lin, F., Liu, G., Lobo, F. S. N., Loll, R., Lombriser, L., Lovelace, G., Macedo, R. P., Madge, E., Maggio, E., Maggiore, M., Marassi, S., Marcoccia, P., Markakis, C., Martens, W., Martinovic, K., Martins, C. J. A. P., Maselli, A., Mastrogiovanni, S., Matarrese, S., Matas, A., Mavromatos, N. E., Mazumdar, A., Meerburg, P. D., Megias, E., Miller, J., Mimoso, J. P., Mittnacht, L., Montero, M. M., Moore, B., Martin-Moruno, P., Musco, I., Nakano, H., Nampalliwar, S., Nardini, G., Nielsen, A., Novák, J., Nunes, N. J., Okounkova, M., Oliveri, R., Oppizzi, F., Orlando, G., Oshita, N., Pappas, G., Paschalidis, V., Peiris, H., Peloso, M., Perkins, S., Pettorino, V., Pikovski, I., Pilo, L., Podolsky, J., Pontzen, A., Prabhat, S., Pratten, G., Prokopec, T., Prouza, M., Qi, H., Raccanelli, A., Rajantie, A., Randall, L., Raposo, G., Raymond, V., Renaux-Petel, S., Ricciardone, A., Riotto, A., Robson, T., Roest, D., Rollo, R., Rosofsky, S., Ruan, J. J., Rubiera-García, D., Ruiz, M., Rusu, M., Sabatie, F., Sago, N., Sakellariadou, M., Saltas, I. D., Sberna, L., Sathyaprakash, B., Scheel, M., Schmidt, P., Schutz, B., Schwaller, P., Shao, L., Shapiro, S. L., Shoemaker, D., Silva, A. d., Simpson, C., Sopuerta, C. F., Spallicci, A., Stefanek, B. A., Stein, L., Stergioulas, N., Stott, M., Sutton, P., Svarc, R., Tagoshi, H., Tahamtan, T., Takeda, H., Tanaka, T., Tantilian, G., Tasinato, G., Tattersall, O., Teukolsky, S., Tiec, A. L., Theureau, G., Trodden, M., Tolley, A., Toubiana, A., Traykova, D., Tsokaros, A., Unal, C., Unnikrishnan, C. S., Vagenas, E. C., Valageas, P., Vallisneri, M., Brand, J. Van den, Broeck, C. Van den, van de Meent, M., Vanhove, P., Varma, V., Veitch, J., Vercnocke, B., Verde, L., Vernieri, D., Vernizzi, F., Vicente, R., Vidotto, F., Visser, M., Vlah, Z., Vretinaris, S., Völkel, S., Wang, Q., Wang, Yu-Tong, Werner, M. C., Westernacher, J., Weygaert, R. v. d., Wiltshire, D., Wiseman, T., Wolf, P., Wu, K., Yamada, K., Yang, H., Yi, L., Yue, X., Yvon, D., Zilhão, M., Zimmerman, A., and Zumalacarregui, M.

Subjects
General Relativity and Quantum Cosmology
Abstract

In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA, we present here a sample of what we view as particularly promising directions, based in part on the current research interests of the LISA scientific community in the area of fundamental physics. We organize these directions through a "science-first" approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics., Comment: 22 pages, 1 figure, to appear in General Relativity and Gravitation

Published
2020
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6. Cosmology with the Laser Interferometer Space Antenna

Author

Auclair, P, Bacon, D, Baker, T, Barreiro, T, Bartolo, N, Belgacem, E, Bellomo, N, Ben-Dayan, I, Bertacca, D, Besancon, M, Blanco-Pillado, J, Blas, D, Boileau, G, Calcagni, G, Caldwell, R, Caprini, C, Carbone, C, Chang, C, Chen, H, Christensen, N, Clesse, S, Comelli, D, Congedo, G, Contaldi, C, Crisostomi, M, Croon, D, Cui, Y, Cusin, G, Cutting, D, Dalang, C, De Luca, V, Pozzo, W, Desjacques, V, Dimastrogiovanni, E, Dorsch, G, Ezquiaga, J, Fasiello, M, Figueroa, D, Flauger, R, Franciolini, G, Frusciante, N, Fumagalli, J, Garcia-Bellido, J, Gould, O, Holz, D, Iacconi, L, Jain, R, Jenkins, A, Jinno, R, Joana, C, Karnesis, N, Konstandin, T, Koyama, K, Kozaczuk, J, Kuroyanagi, S, Laghi, D, Lewicki, M, Lombriser, L, Madge, E, Maggiore, M, Malhotra, A, Mancarella, M, Mandic, V, Mangiagli, A, Matarrese, S, Mazumdar, A, Mukherjee, S, Musco, I, Nardini, G, No, J, Papanikolaou, T, Peloso, M, Pieroni, M, Pilo, L, Raccanelli, A, Renaux-Petel, S, Renzini, A, Ricciardone, A, Riotto, A, Romano, J, Rollo, R, Pol, A, Morales, E, Sakellariadou, M, Saltas, I, Scalisi, M, Schmitz, K, Schwaller, P, Sergijenko, O, Servant, G, Simakachorn, P, Sorbo, L, Sousa, L, Speri, L, Steer, D, Tamanini, N, Tasinato, G, Torrado, J, Unal, C, Vennin, V, Vernieri, D, Vernizzi, F, Volonteri, M, Wachter, J, Wands, D, Witkowski, L, Zumalacarregui, M, Annis, J, Ares, F, Avelino, P, Avgoustidis, A, Barausse, E, Bonilla, A, Bonvin, C, Bosso, P, Calabrese, M, Caliskan, M, Cembranos, J, Chala, M, Chernoff, D, Clough, K, Criswell, A, Das, S, Silva, A, Dayal, P, Domcke, V, Durrer, R, Easther, R, Escoffier, S, Ferrans, S, Fryer, C, Gair, J, Gordon, C, Hendry, M, Hindmarsh, M, Hooper, D, Kajfasz, E, Kopp, J, Koushiappas, S, Kumar, U, Kunz, M, Lagos, M, Lilley, M, Lizarraga, J, Lobo, F, Maleknejad, A, Martins, C, Meerburg, P, Meyer, R, Mimoso, J, Nesseris, S, Nunes, N, Oikonomou, V, Orlando, G, Ozsoy, O, Pacucci, F, Palmese, A, Petiteau, A, Pinol, L, Zwart, S, Pratten, G, Prokopec, T, Quenby, J, Rastgoo, S, Roest, D, Rummukainen, K, Schimd, C, Secroun, A, Sesana, A, Sopuerta, C, Tereno, I, Tolley, A, Urrestilla, J, Vagenas, E, van de Vis, J, van de Weygaert, R, Wardell, B, Weir, D, White, G, Swiezewska, B, Zhdanov, V, Auclair P., Bacon D., Baker T., Barreiro T., Bartolo N., Belgacem E., Bellomo N., Ben-Dayan I., Bertacca D., Besancon M., Blanco-Pillado J. J., Blas D., Boileau G., Calcagni G., Caldwell R., Caprini C., Carbone C., Chang C. -F., Chen H. -Y., Christensen N., Clesse S., Comelli D., Congedo G., Contaldi C., Crisostomi M., Croon D., Cui Y., Cusin G., Cutting D., Dalang C., De Luca V., Pozzo W. D., Desjacques V., Dimastrogiovanni E., Dorsch G. C., Ezquiaga J. M., Fasiello M., Figueroa D. G., Flauger R., Franciolini G., Frusciante N., Fumagalli J., Garcia-Bellido J., Gould O., Holz D., Iacconi L., Jain R. K., Jenkins A. C., Jinno R., Joana C., Karnesis N., Konstandin T., Koyama K., Kozaczuk J., Kuroyanagi S., Laghi D., Lewicki M., Lombriser L., Madge E., Maggiore M., Malhotra A., Mancarella M., Mandic V., Mangiagli A., Matarrese S., Mazumdar A., Mukherjee S., Musco I., Nardini G., No J. M., Papanikolaou T., Peloso M., Pieroni M., Pilo L., Raccanelli A., Renaux-Petel S., Renzini A. I., Ricciardone A., Riotto A., Romano J. D., Rollo R., Pol A. R., Morales E. R., Sakellariadou M., Saltas I. D., Scalisi M., Schmitz K., Schwaller P., Sergijenko O., Servant G., Simakachorn P., Sorbo L., Sousa L., Speri L., Steer D. A., Tamanini N., Tasinato G., Torrado J., Unal C., Vennin V., Vernieri D., Vernizzi F., Volonteri M., Wachter J. M., Wands D., Witkowski L. T., Zumalacarregui M., Annis J., Ares F. R., Avelino P. P., Avgoustidis A., Barausse E., Bonilla A., Bonvin C., Bosso P., Calabrese M., Caliskan M., Cembranos J. A. R., Chala M., Chernoff D., Clough K., Criswell A., Das S., Silva A., Dayal P., Domcke V., Durrer R., Easther R., Escoffier S., Ferrans S., Fryer C., Gair J., Gordon C., Hendry M., Hindmarsh M., Hooper D. C., Kajfasz E., Kopp J., Koushiappas S. M., Kumar U., Kunz M., Lagos M., Lilley M., Lizarraga J., Lobo F. S. N., Maleknejad A., Martins C. J. A. P., Meerburg P. D., Meyer R., Mimoso J. P., Nesseris S., Nunes N., Oikonomou V., Orlando G., Ozsoy O., Pacucci F., Palmese A., Petiteau A., Pinol L., Zwart S. P., Pratten G., Prokopec T., Quenby J., Rastgoo S., Roest D., Rummukainen K., Schimd C., Secroun A., Sesana A., Sopuerta C. F., Tereno I., Tolley A., Urrestilla J., Vagenas E. C., van de Vis J., van de Weygaert R., Wardell B., Weir D. J., White G., Swiezewska B., Zhdanov V. I., Auclair, P, Bacon, D, Baker, T, Barreiro, T, Bartolo, N, Belgacem, E, Bellomo, N, Ben-Dayan, I, Bertacca, D, Besancon, M, Blanco-Pillado, J, Blas, D, Boileau, G, Calcagni, G, Caldwell, R, Caprini, C, Carbone, C, Chang, C, Chen, H, Christensen, N, Clesse, S, Comelli, D, Congedo, G, Contaldi, C, Crisostomi, M, Croon, D, Cui, Y, Cusin, G, Cutting, D, Dalang, C, De Luca, V, Pozzo, W, Desjacques, V, Dimastrogiovanni, E, Dorsch, G, Ezquiaga, J, Fasiello, M, Figueroa, D, Flauger, R, Franciolini, G, Frusciante, N, Fumagalli, J, Garcia-Bellido, J, Gould, O, Holz, D, Iacconi, L, Jain, R, Jenkins, A, Jinno, R, Joana, C, Karnesis, N, Konstandin, T, Koyama, K, Kozaczuk, J, Kuroyanagi, S, Laghi, D, Lewicki, M, Lombriser, L, Madge, E, Maggiore, M, Malhotra, A, Mancarella, M, Mandic, V, Mangiagli, A, Matarrese, S, Mazumdar, A, Mukherjee, S, Musco, I, Nardini, G, No, J, Papanikolaou, T, Peloso, M, Pieroni, M, Pilo, L, Raccanelli, A, Renaux-Petel, S, Renzini, A, Ricciardone, A, Riotto, A, Romano, J, Rollo, R, Pol, A, Morales, E, Sakellariadou, M, Saltas, I, Scalisi, M, Schmitz, K, Schwaller, P, Sergijenko, O, Servant, G, Simakachorn, P, Sorbo, L, Sousa, L, Speri, L, Steer, D, Tamanini, N, Tasinato, G, Torrado, J, Unal, C, Vennin, V, Vernieri, D, Vernizzi, F, Volonteri, M, Wachter, J, Wands, D, Witkowski, L, Zumalacarregui, M, Annis, J, Ares, F, Avelino, P, Avgoustidis, A, Barausse, E, Bonilla, A, Bonvin, C, Bosso, P, Calabrese, M, Caliskan, M, Cembranos, J, Chala, M, Chernoff, D, Clough, K, Criswell, A, Das, S, Silva, A, Dayal, P, Domcke, V, Durrer, R, Easther, R, Escoffier, S, Ferrans, S, Fryer, C, Gair, J, Gordon, C, Hendry, M, Hindmarsh, M, Hooper, D, Kajfasz, E, Kopp, J, Koushiappas, S, Kumar, U, Kunz, M, Lagos, M, Lilley, M, Lizarraga, J, Lobo, F, Maleknejad, A, Martins, C, Meerburg, P, Meyer, R, Mimoso, J, Nesseris, S, Nunes, N, Oikonomou, V, Orlando, G, Ozsoy, O, Pacucci, F, Palmese, A, Petiteau, A, Pinol, L, Zwart, S, Pratten, G, Prokopec, T, Quenby, J, Rastgoo, S, Roest, D, Rummukainen, K, Schimd, C, Secroun, A, Sesana, A, Sopuerta, C, Tereno, I, Tolley, A, Urrestilla, J, Vagenas, E, van de Vis, J, van de Weygaert, R, Wardell, B, Weir, D, White, G, Swiezewska, B, Zhdanov, V, Auclair P., Bacon D., Baker T., Barreiro T., Bartolo N., Belgacem E., Bellomo N., Ben-Dayan I., Bertacca D., Besancon M., Blanco-Pillado J. J., Blas D., Boileau G., Calcagni G., Caldwell R., Caprini C., Carbone C., Chang C. -F., Chen H. -Y., Christensen N., Clesse S., Comelli D., Congedo G., Contaldi C., Crisostomi M., Croon D., Cui Y., Cusin G., Cutting D., Dalang C., De Luca V., Pozzo W. D., Desjacques V., Dimastrogiovanni E., Dorsch G. C., Ezquiaga J. M., Fasiello M., Figueroa D. G., Flauger R., Franciolini G., Frusciante N., Fumagalli J., Garcia-Bellido J., Gould O., Holz D., Iacconi L., Jain R. K., Jenkins A. C., Jinno R., Joana C., Karnesis N., Konstandin T., Koyama K., Kozaczuk J., Kuroyanagi S., Laghi D., Lewicki M., Lombriser L., Madge E., Maggiore M., Malhotra A., Mancarella M., Mandic V., Mangiagli A., Matarrese S., Mazumdar A., Mukherjee S., Musco I., Nardini G., No J. M., Papanikolaou T., Peloso M., Pieroni M., Pilo L., Raccanelli A., Renaux-Petel S., Renzini A. I., Ricciardone A., Riotto A., Romano J. D., Rollo R., Pol A. R., Morales E. R., Sakellariadou M., Saltas I. D., Scalisi M., Schmitz K., Schwaller P., Sergijenko O., Servant G., Simakachorn P., Sorbo L., Sousa L., Speri L., Steer D. A., Tamanini N., Tasinato G., Torrado J., Unal C., Vennin V., Vernieri D., Vernizzi F., Volonteri M., Wachter J. M., Wands D., Witkowski L. T., Zumalacarregui M., Annis J., Ares F. R., Avelino P. P., Avgoustidis A., Barausse E., Bonilla A., Bonvin C., Bosso P., Calabrese M., Caliskan M., Cembranos J. A. R., Chala M., Chernoff D., Clough K., Criswell A., Das S., Silva A., Dayal P., Domcke V., Durrer R., Easther R., Escoffier S., Ferrans S., Fryer C., Gair J., Gordon C., Hendry M., Hindmarsh M., Hooper D. C., Kajfasz E., Kopp J., Koushiappas S. M., Kumar U., Kunz M., Lagos M., Lilley M., Lizarraga J., Lobo F. S. N., Maleknejad A., Martins C. J. A. P., Meerburg P. D., Meyer R., Mimoso J. P., Nesseris S., Nunes N., Oikonomou V., Orlando G., Ozsoy O., Pacucci F., Palmese A., Petiteau A., Pinol L., Zwart S. P., Pratten G., Prokopec T., Quenby J., Rastgoo S., Roest D., Rummukainen K., Schimd C., Secroun A., Sesana A., Sopuerta C. F., Tereno I., Tolley A., Urrestilla J., Vagenas E. C., van de Vis J., van de Weygaert R., Wardell B., Weir D. J., White G., Swiezewska B., and Zhdanov V. I.

Abstract

The Laser Interferometer Space Antenna (LISA) has two scientific objectives of cosmological focus: to probe the expansion rate of the universe, and to understand stochastic gravitational-wave backgrounds and their implications for early universe and particle physics, from the MeV to the Planck scale. However, the range of potential cosmological applications of gravitational-wave observations extends well beyond these two objectives. This publication presents a summary of the state of the art in LISA cosmology, theory and methods, and identifies new opportunities to use gravitational-wave observations by LISA to probe the universe.

Published
2023

7. Opportunities and challenges to using a cross-sectional, patient-reported experience measure of shared decision making to evaluate the impact of an intervention centered on serious illness conversations in oncology.

Author

Wasp, Garrett Thomas, primary, Guo, Karen, additional, Vergo, Maxwell Thomas, additional, Wilson, Matthew, additional, Buus-Frank, Madge E, additional, Perry, James J., additional, Holthoff, Megan M., additional, Van Citters, Aricca D., additional, and Cullinan, Amelia M., additional

Published
2023
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9. Interdisciplinary Approach and Patient/Family Partners to Improve Serious Illness Conversations in Outpatient Oncology

Author

Garrett T. Wasp, Amelia M. Cullinan, Catherine P. Anton, Andy Williams, James J. Perry, Megan M. Holthoff, and Madge E. Buus-Frank

Subjects
Oncology, Oncology (nursing), Communication, Health Policy, Outpatients, Palliative Care, Humans, Medical Oncology, Quality Improvement
Abstract

PURPOSE: We aimed to increase Serious Illness Conversations (SIC) from a baseline of, at or near, zero to 25% of eligible patients by December 31, 2020. METHODS: We assembled an interdisciplinary team inclusive of a family partner and used the Model for Improvement as our quality improvement framework. The team developed a SMART Aim, key driver diagram, and SIC workflow. Standardized screening for SIC eligibility was implemented using the 2-year surprise question. Team members were trained in SIC communication skills by a trained facilitator and received ongoing coaching in quality improvement. We performed Plan-Do-Study-Act cycles and used audit-feedback data in weekly team meetings to inform iterative Plan-Do-Study-Act cycles. The primary outcome was the percent of eligible patients with documented SIC. RESULTS: Over 18 months, three clinics identified 63 eligible patients; of these, 32 (51%) were diagnosed with head and neck cancer and 31 (49%) with sarcoma. The SIC increased from a baseline near zero to 43 of 63 (70%) patients demonstrating three shifts in the median (95% CI). Conversations were interdisciplinary with 25 (57%) by oncology MD, six (14%) by advanced practice registered nurse, and 13 (30%) by specialty palliative care. We targeted four key drivers: (1) standardized work, (2) engaged interdisciplinary team, (3) engaged patients and families, and (4) system-level support. CONCLUSION: Our approach was successful in its documentation of end points and required resource investment (training and time) to embed into team workflows. Future work will evaluate scaling the approach across multiple clinics, the patient experience, and outcomes of care associated with oncology clinician–led SIC.

Published
2022
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15. The Cystic Fibrosis Learning Network: A mixed methods evaluation of program goals, attributes, and impact.

Author

Van Citters, Aricca D., Buus‐Frank, Madge E., King, Joel R., Seid, Michael, Holthoff, Megan M., Amin, Raouf S., Britto, Maria T., Nelson, Eugene C., Marshall, Bruce C., and Sabadosa, Kathryn A.

Subjects
CYSTIC fibrosis, EVALUATION methodology, LEARNING communities, THEMATIC analysis, SEMI-structured interviews
Abstract

Introduction: The Cystic Fibrosis (CF) Foundation sponsored the design, pilot testing, and implementation of the CF Learning Network (CFLN) to explore how the Foundation's Care Center Network (CCN) could become a learning health system. Six years after the design, the Foundation commissioned a formative mixed methods evaluation of the CFLN to assess: CFLN participants' understanding of program goals, attributes, and perceptions of current and future impact. Methods: We performed semi‐structured interviews with CFLN participants to identify perceived goals, attributes, and impact of the network. Following thematic analyses, we developed and distributed a survey to CFLN members and a matched sample of CCN programs to understand whether the themes were unique to the CFLN. Results: Interviews with 24 CFLN participants were conducted. Interviewees identified the primary CFLN goal as improving outcomes for people living with CF, with secondary goals of providing training in quality improvement (QI), creating a learning community, engaging all stakeholders in improvement, and spreading best practices to the CCN. Project management, use of data, common QI methods, and the learning community were seen as critical to success. Survey responses were collected from 103 CFLN members and 25 CCN members. The data revealed that CFLN respondents were more likely than CCN respondents to connect with other CF programs, routinely use data for QI, and engage patient and family partners in QI. Conclusions: Our study suggests that the CFLN provides value beyond that achieved by the CCN. Key questions remain about whether spread of the CFLN could improve outcomes for more people living with CF. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Improving Outcomes through a Neonatal Abstinence Syndrome Collaborative in Maryland

Author

Bonnie, DiPietro, Kristin, Silcox, James, Rost, Lee S, Woods, Erika M, Edwards, Madge E, Buus-Frank, Jeffrey D, Horbar, and Mark L, Hudak

Subjects
Pediatrics, Perinatology and Child Health, Obstetrics and Gynecology
Abstract

A statewide Maryland Perinatal Neonatal Quality Collaborative, facilitated by the Maryland Patient Safety Center (MPSC), identified the three specific, measurable, attainable, relevant, and time-limited (SMART) aims to improve outcomes of neonatal abstinence syndrome (NAS) care as follows: (1) to reduce hospital length of stay (LOS), (2) to reduce interhospital transfers, and (3) to reduce 30-day readmission rates of infants with NAS. The Maryland collaborative developed a bundle of best practices for care of infants with NAS. MPSC partnered with Vermont Oxford Network (VON) to utilize the VON NAS toolkit and provided its standardized NAS educational curriculum to address the three objectives for participating birthing hospitals. Efforts began in quarter 4 (Q4) of 2016 and continued for 2 years. Thirty-one of Maryland's 32 delivery hospitals (97%) participated in the 2-year collaborative. Additionally, one specialty pediatric hospital with an NAS unit participated in the group learnings. Participating facilities implemented components of the MPSC NAS bundle and provided their staff caring for infants with NAS and their mothers access to the VON standardized educational curriculum. MPSC partnered with VON to conduct two audits of implementation of policies and procedures in Q1 of 2016 and Q3 of 2018. The Maryland Department of Health supplied quarterly aggregate hospital information on LOS, interhospital transfers, and 30-day readmissions of infants with a discharge diagnosis of the International Classification of Disease, 10th Revision (ICD-10), P96.1. Among term infants with NAS with total hospital stay greater than 5 days, we observed a nonsignificant reduction in both mean and median LOS of 1.5 days. In this same group, the rate of interhospital transfers fell significantly from 20.1% in 2016 to 13.8 and 11.0% in 2017 and 2018, respectively. The best practice bundle created by the Maryland collaborative was associated with a reduction in the percentage of infants with NAS who required interhospital transfer, thereby reducing family disruption.· A state NAS collaborative engaged 97% of delivery hospitals in education and standardization of care.. · The collaborative witnessed a 1.5-day decrease in length of stay, similar to that observed in other state collaboratives.. · The unique outcome of our collaborative was a 50% decrease in the rate of interhospital transfer..

Published
2022
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17. Prioritizing Measures That Matter Within a Person-Centered Oncology Learning Health System

Author

Van Citters, Aricca D., Kennedy, Alice M., Kirkland, Kathryn B., Dragnev, Konstantin H., Leach, Steven D., Buus-Frank, Madge E., Malcolm, Elissa F., Holthoff, Megan M., Holmes, Anne B., Nelson, Eugene C., Reeves, Susan A., Tosteson, Anna N. A., Van Citters, Aricca D., Kennedy, Alice M., Kirkland, Kathryn B., Dragnev, Konstantin H., Leach, Steven D., Buus-Frank, Madge E., Malcolm, Elissa F., Holthoff, Megan M., Holmes, Anne B., Nelson, Eugene C., Reeves, Susan A., and Tosteson, Anna N. A.

Abstract

Background Despite progress in developing learning health systems (LHS) and associated metrics of success, a gap remains in identifying measures to guide the implementation and assessment of the impact of an oncology LHS. Our aim was to identify a balanced set of measures to guide a person-centered oncology LHS. Methods A modified Delphi process and clinical value compass framework were used to prioritize measures for tracking LHS performance. A multidisciplinary group of 77 stakeholders, including people with cancer and family members, participated in 3 rounds of online voting followed by 50-minute discussions. Participants rated metrics on perceived importance to the LHS and discussed priorities. Results Voting was completed by 94% of participants and prioritized 22 measures within 8 domains. Patient and caregiver factors included clinical health (Eastern Cooperative Oncology Group Performance Status, survival by cancer type and stage), functional health and quality of life (Patient Reported Outcomes Measurement Information System [PROMIS] Global-10, Distress Thermometer, Modified Caregiver Strain Index), experience of care (advance care planning, collaboRATE, PROMIS Self-Efficacy Scale, access to care, experience of care, end-of-life quality measures), and cost and resource use (avoidance and delay in accessing care and medications, financial hardship, total cost of care). Contextual factors included team well-being (Well-being Index; voluntary staff turnover); learning culture (Improvement Readiness, compliance with Commission on Cancer quality of care measures); scholarly engagement and productivity (institutional commitment and support for research, academic productivity index); and diversity, equity, inclusion, and belonging (screening and follow-up for social determinants of health, inclusivity of staff and patients). Conclusions The person-centered LHS value compass provides a balanced set of measures that oncology practices can use to monitor and evaluate

Published
2022
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19. Prospects for fundamental physics with LISA

Author

Barausse, E, Berti, E, Hertog, T, Hughes, S, Jetzer, P, Pani, P, Sotiriou, T, Tamanini, N, Witek, H, Yagi, K, Yunes, N, Abdelsalhin, T, Achucarro, A, van Aelst, K, Afshordi, N, Akcay, S, Annulli, L, Arun, K, Ayuso, I, Baibhav, V, Baker, T, Bantilan, H, Barreiro, T, Barrera-Hinojosa, C, Bartolo, N, Baumann, D, Belgacem, E, Bellini, E, Bellomo, N, Ben-Dayan, I, Bena, I, Benkel, R, Bergshoefs, E, Bernard, L, Bernuzzi, S, Bertacca, D, Besancon, M, Beutler, F, Beyer, F, Bhagwat, S, Bicak, J, Biondini, S, Bize, S, Blas, D, Boehmer, C, Boller, K, Bonga, B, Bonvin, C, Bosso, P, Bozzola, G, Brax, P, Breitbach, M, Brito, R, Bruni, M, Brügmann, B, Bulten, H, Buonanno, A, Burko, L, Burrage, C, Cabral, F, Calcagni, G, Caprini, C, Cárdenas-Avendaño, A, Celoria, M, Chatziioannou, K, Chernoff, D, Clough, K, Coates, A, Comelli, D, Compère, G, Croon, D, Cruces, D, Cusin, G, Dalang, C, Danielsson, U, Das, S, Datta, S, de Boer, J, De Luca, V, De Rham, C, Desjacques, V, Destounis, K, Filippo, F, Dima, A, Dimastrogiovanni, E, Dolan, S, Doneva, D, Duque, F, Durrer, R, East, W, Easther, R, Elley, M, Ellis, J, Emparan, R, Ezquiaga, J, Fairbairn, M, Fairhurst, S, Farmer, H, Fasiello, M, Ferrari, V, Ferreira, P, Ficarra, G, Figueras, P, Fisenko, S, Foffa, S, Franchini, N, Franciolini, G, Fransen, K, Frauendiener, J, Frusciante, N, Fujita, R, Gair, J, Ganz, A, Garcia, P, Garcia-Bellido, J, Garriga, J, Geiger, R, Geng, C, Gergely, L, Germani, C, Gerosa, D, Giddings, S, Gourgoulhon, E, Grandclement, P, Graziani, L, Gualtieri, L, Haggard, D, Haino, S, Halburd, R, Han, W, Hawken, A, Hees, A, Heng, I, Hennig, J, Herdeiro, C, Hervik, S, Holten, J, Hoyle, C, Hu, Y, Hull, M, Ikeda, T, Isi, M, Jenkins, A, Julié, F, Kajfasz, E, Kalaghatgi, C, Kaloper, N, Kamionkowski, M, Karas, V, Kastha, S, Keresztes, Z, Kidder, L, Kimpson, T, Klein, A, Klioner, S, Kokkotas, K, Kolesova, H, Kolkowitz, S, Kopp, J, Koyama, K, Krishnendu, N, Kroon, J, Kunz, M, Lahav, O, Landragin, A, Lang, R, Poncin-Lafitte, C, Lemos, J, Li, B, Liberati, S, Liguori, M, Lin, F, Liu, G, Lobo, F, Loll, R, Lombriser, L, Lovelace, G, Macedo, R, Madge, E, Maggio, E, Maggiore, M, Marassi, S, Marcoccia, P, Markakis, C, Martens, W, Martinovic, K, Martins, C, Maselli, A, Mastrogiovanni, S, Matarrese, S, Matas, A, Mavromatos, N, Mazumdar, A, Meerburg, P, Megias, E, Miller, J, Mimoso, J, Mittnacht, L, Montero, M, Moore, B, Martin-Moruno, P, Musco, I, Nakano, H, Nampalliwar, S, Nardini, G, Nielsen, A, Novák, J, Nunes, N, Okounkova, M, Oliveri, R, Oppizzi, F, Orlando, G, Oshita, N, Pappas, G, Paschalidis, V, Peiris, H, Peloso, M, Perkins, S, Pettorino, V, Pikovski, I, Pilo, L, Podolsky, J, Pontzen, A, Prabhat, S, Pratten, G, Prokopec, T, Prouza, M, Qi, H, Raccanelli, A, Rajantie, A, Randall, L, Raposo, G, Raymond, V, Renaux-Petel, S, Ricciardone, A, Riotto, A, Robson, T, Roest, D, Rollo, R, Rosofsky, S, Ruan, J, Rubiera-García, D, Ruiz, M, Rusu, M, Sabatie, F, Sago, N, Sakellariadou, M, Saltas, I, Sberna, L, Sathyaprakash, B, Scheel, M, Schmidt, P, Schutz, B, Schwaller, P, Shao, L, Shapiro, S, Shoemaker, D, Silva, A, Simpson, C, Sopuerta, C, Spallicci, A, Stefanek, B, Stein, L, Stergioulas, N, Stott, M, Sutton, P, Svarc, R, Tagoshi, H, Tahamtan, T, Takeda, H, Tanaka, T, Tantilian, G, Tasinato, G, Tattersall, O, Teukolsky, S, Tiec, A, Theureau, G, Trodden, M, Tolley, A, Toubiana, A, Traykova, D, Tsokaros, A, Unal, C, Unnikrishnan, C, Vagenas, E, Valageas, P, Vallisneri, M, Brand, J, Broeck, C, de Meent, M, Vanhove, P, Varma, V, Veitch, J, Vercnocke, B, Verde, L, Vernieri, D, Vernizzi, F, Vicente, R, Vidotto, F, Visser, M, Vlah, Z, Vretinaris, S, Völkel, S, Wang, Q, Wang, Y, Werner, M, Westernacher, J, Weygaert, R, Wiltshire, D, Wiseman, T, Wolf, P, Wu, K, Yamada, K, Yang, H, Yi, L, Yue, X, Yvon, D, Zilhão, M, Zimmerman, A, Zumalacarregui, M, Barausse, Enrico, Berti, Emanuele, Hertog, Thomas, Hughes, Scott A., Jetzer, Philippe, Pani, Paolo, Sotiriou, Thomas P., Tamanini, Nicola, Witek, Helvi, Yagi, Kent, Yunes, Nicolás, Abdelsalhin, T., Achucarro, A., van Aelst, K., Afshordi, N., Akcay, S., Annulli, L., Arun, K. G., Ayuso, I., Baibhav, V., Baker, T., Bantilan, H., Barreiro, T., Barrera-Hinojosa, C., Bartolo, N., Baumann, D., Belgacem, E., Bellini, E., Bellomo, N., Ben-Dayan, I., Bena, I., Benkel, R., Bergshoefs, E., Bernard, L., Bernuzzi, S., Bertacca, D., Besancon, M., Beutler, F., Beyer, F., Bhagwat, S., Bicak, J., Biondini, S., Bize, S., Blas, D., Boehmer, C., Boller, K., Bonga, B., Bonvin, C., Bosso, P., Bozzola, G., Brax, P., Breitbach, M., Brito, R., Bruni, M., Brügmann, B., Bulten, H., Buonanno, A., Burko, L. M., Burrage, C., Cabral, F., Calcagni, G., Caprini, C., Cárdenas-Avendaño, A., Celoria, M., Chatziioannou, K., Chernoff, D., Clough, K., Coates, A., Comelli, D., Compère, G., Croon, D., Cruces, D., Cusin, G., Dalang, C., Danielsson, U., Das, S., Datta, S., de Boer, J., De Luca, V., De Rham, C., Desjacques, V., Destounis, K., Filippo, F. Di, Dima, A., Dimastrogiovanni, E., Dolan, S., Doneva, D., Duque, F., Durrer, R., East, W., Easther, R., Elley, M., Ellis, J. R., Emparan, R., Ezquiaga, J. M., Fairbairn, M., Fairhurst, S., Farmer, H. F., Fasiello, M. R., Ferrari, V., Ferreira, P. G., Ficarra, G., Figueras, P., Fisenko, S., Foffa, S., Franchini, N., Franciolini, G., Fransen, K., Frauendiener, J., Frusciante, N., Fujita, R., Gair, J., Ganz, A., Garcia, P., Garcia-Bellido, J., Garriga, J., Geiger, R., Geng, C., Gergely, L. Á., Germani, C., Gerosa, D., Giddings, S. B., Gourgoulhon, E., Grandclement, P., Graziani, L., Gualtieri, L., Haggard, D., Haino, S., Halburd, R., Han, W. -B., Hawken, A. J., Hees, A., Heng, I. S., Hennig, J., Herdeiro, C., Hervik, S., Holten, J. v., Hoyle, C. J. D., Hu, Y., Hull, M., Ikeda, T., Isi, M., Jenkins, A., Julié, F., Kajfasz, E., Kalaghatgi, C., Kaloper, N., Kamionkowski, M., Karas, V., Kastha, S., Keresztes, Z., Kidder, L., Kimpson, T., Klein, A., Klioner, S., Kokkotas, K., Kolesova, H., Kolkowitz, S., Kopp, J., Koyama, K., Krishnendu, N. V., Kroon, J. A. V., Kunz, M., Lahav, O., Landragin, A., Lang, R. N., Poncin-Lafitte, C. Le, Lemos, J., Li, B., Liberati, S., Liguori, M., Lin, F., Liu, G., Lobo, F. S. N., Loll, R., Lombriser, L., Lovelace, G., Macedo, R. P., Madge, E., Maggio, E., Maggiore, M., Marassi, S., Marcoccia, P., Markakis, C., Martens, W., Martinovic, K., Martins, C. J. A. P., Maselli, A., Mastrogiovanni, S., Matarrese, S., Matas, A., Mavromatos, N. E., Mazumdar, A., Meerburg, P. D., Megias, E., Miller, J., Mimoso, J. P., Mittnacht, L., Montero, M. M., Moore, B., Martin-Moruno, P., Musco, I., Nakano, H., Nampalliwar, S., Nardini, G., Nielsen, A., Novák, J., Nunes, N. J., Okounkova, M., Oliveri, R., Oppizzi, F., Orlando, G., Oshita, N., Pappas, G., Paschalidis, V., Peiris, H., Peloso, M., Perkins, S., Pettorino, V., Pikovski, I., Pilo, L., Podolsky, J., Pontzen, A., Prabhat, S., Pratten, G., Prokopec, T., Prouza, M., Qi, H., Raccanelli, A., Rajantie, A., Randall, L., Raposo, G., Raymond, V., Renaux-Petel, S., Ricciardone, A., Riotto, A., Robson, T., Roest, D., Rollo, R., Rosofsky, S., Ruan, J. J., Rubiera-García, D., Ruiz, M., Rusu, M., Sabatie, F., Sago, N., Sakellariadou, M., Saltas, I. D., Sberna, L., Sathyaprakash, B., Scheel, M., Schmidt, P., Schutz, B., Schwaller, P., Shao, L., Shapiro, S. L., Shoemaker, D., Silva, A. d., Simpson, C., Sopuerta, C. F., Spallicci, A., Stefanek, B. A., Stein, L., Stergioulas, N., Stott, M., Sutton, P., Svarc, R., Tagoshi, H., Tahamtan, T., Takeda, H., Tanaka, T., Tantilian, G., Tasinato, G., Tattersall, O., Teukolsky, S., Tiec, A. L., Theureau, G., Trodden, M., Tolley, A., Toubiana, A., Traykova, D., Tsokaros, A., Unal, C., Unnikrishnan, C. S., Vagenas, E. C., Valageas, P., Vallisneri, M., Brand, J. Van den, Broeck, C. Van den, de Meent, M. van, Vanhove, P., Varma, V., Veitch, J., Vercnocke, B., Verde, L., Vernieri, D., Vernizzi, F., Vicente, R., Vidotto, F., Visser, M., Vlah, Z., Vretinaris, S., Völkel, S., Wang, Q., Wang, Yu-Tong, Werner, M. C., Westernacher, J., Weygaert, R. v. d., Wiltshire, D., Wiseman, T., Wolf, P., Wu, K., Yamada, K., Yang, H., Yi, L., Yue, X., Yvon, D., Zilhão, M., Zimmerman, A., Zumalacarregui, M., Barausse, E, Berti, E, Hertog, T, Hughes, S, Jetzer, P, Pani, P, Sotiriou, T, Tamanini, N, Witek, H, Yagi, K, Yunes, N, Abdelsalhin, T, Achucarro, A, van Aelst, K, Afshordi, N, Akcay, S, Annulli, L, Arun, K, Ayuso, I, Baibhav, V, Baker, T, Bantilan, H, Barreiro, T, Barrera-Hinojosa, C, Bartolo, N, Baumann, D, Belgacem, E, Bellini, E, Bellomo, N, Ben-Dayan, I, Bena, I, Benkel, R, Bergshoefs, E, Bernard, L, Bernuzzi, S, Bertacca, D, Besancon, M, Beutler, F, Beyer, F, Bhagwat, S, Bicak, J, Biondini, S, Bize, S, Blas, D, Boehmer, C, Boller, K, Bonga, B, Bonvin, C, Bosso, P, Bozzola, G, Brax, P, Breitbach, M, Brito, R, Bruni, M, Brügmann, B, Bulten, H, Buonanno, A, Burko, L, Burrage, C, Cabral, F, Calcagni, G, Caprini, C, Cárdenas-Avendaño, A, Celoria, M, Chatziioannou, K, Chernoff, D, Clough, K, Coates, A, Comelli, D, Compère, G, Croon, D, Cruces, D, Cusin, G, Dalang, C, Danielsson, U, Das, S, Datta, S, de Boer, J, De Luca, V, De Rham, C, Desjacques, V, Destounis, K, Filippo, F, Dima, A, Dimastrogiovanni, E, Dolan, S, Doneva, D, Duque, F, Durrer, R, East, W, Easther, R, Elley, M, Ellis, J, Emparan, R, Ezquiaga, J, Fairbairn, M, Fairhurst, S, Farmer, H, Fasiello, M, Ferrari, V, Ferreira, P, Ficarra, G, Figueras, P, Fisenko, S, Foffa, S, Franchini, N, Franciolini, G, Fransen, K, Frauendiener, J, Frusciante, N, Fujita, R, Gair, J, Ganz, A, Garcia, P, Garcia-Bellido, J, Garriga, J, Geiger, R, Geng, C, Gergely, L, Germani, C, Gerosa, D, Giddings, S, Gourgoulhon, E, Grandclement, P, Graziani, L, Gualtieri, L, Haggard, D, Haino, S, Halburd, R, Han, W, Hawken, A, Hees, A, Heng, I, Hennig, J, Herdeiro, C, Hervik, S, Holten, J, Hoyle, C, Hu, Y, Hull, M, Ikeda, T, Isi, M, Jenkins, A, Julié, F, Kajfasz, E, Kalaghatgi, C, Kaloper, N, Kamionkowski, M, Karas, V, Kastha, S, Keresztes, Z, Kidder, L, Kimpson, T, Klein, A, Klioner, S, Kokkotas, K, Kolesova, H, Kolkowitz, S, Kopp, J, Koyama, K, Krishnendu, N, Kroon, J, Kunz, M, Lahav, O, Landragin, A, Lang, R, Poncin-Lafitte, C, Lemos, J, Li, B, Liberati, S, Liguori, M, Lin, F, Liu, G, Lobo, F, Loll, R, Lombriser, L, Lovelace, G, Macedo, R, Madge, E, Maggio, E, Maggiore, M, Marassi, S, Marcoccia, P, Markakis, C, Martens, W, Martinovic, K, Martins, C, Maselli, A, Mastrogiovanni, S, Matarrese, S, Matas, A, Mavromatos, N, Mazumdar, A, Meerburg, P, Megias, E, Miller, J, Mimoso, J, Mittnacht, L, Montero, M, Moore, B, Martin-Moruno, P, Musco, I, Nakano, H, Nampalliwar, S, Nardini, G, Nielsen, A, Novák, J, Nunes, N, Okounkova, M, Oliveri, R, Oppizzi, F, Orlando, G, Oshita, N, Pappas, G, Paschalidis, V, Peiris, H, Peloso, M, Perkins, S, Pettorino, V, Pikovski, I, Pilo, L, Podolsky, J, Pontzen, A, Prabhat, S, Pratten, G, Prokopec, T, Prouza, M, Qi, H, Raccanelli, A, Rajantie, A, Randall, L, Raposo, G, Raymond, V, Renaux-Petel, S, Ricciardone, A, Riotto, A, Robson, T, Roest, D, Rollo, R, Rosofsky, S, Ruan, J, Rubiera-García, D, Ruiz, M, Rusu, M, Sabatie, F, Sago, N, Sakellariadou, M, Saltas, I, Sberna, L, Sathyaprakash, B, Scheel, M, Schmidt, P, Schutz, B, Schwaller, P, Shao, L, Shapiro, S, Shoemaker, D, Silva, A, Simpson, C, Sopuerta, C, Spallicci, A, Stefanek, B, Stein, L, Stergioulas, N, Stott, M, Sutton, P, Svarc, R, Tagoshi, H, Tahamtan, T, Takeda, H, Tanaka, T, Tantilian, G, Tasinato, G, Tattersall, O, Teukolsky, S, Tiec, A, Theureau, G, Trodden, M, Tolley, A, Toubiana, A, Traykova, D, Tsokaros, A, Unal, C, Unnikrishnan, C, Vagenas, E, Valageas, P, Vallisneri, M, Brand, J, Broeck, C, de Meent, M, Vanhove, P, Varma, V, Veitch, J, Vercnocke, B, Verde, L, Vernieri, D, Vernizzi, F, Vicente, R, Vidotto, F, Visser, M, Vlah, Z, Vretinaris, S, Völkel, S, Wang, Q, Wang, Y, Werner, M, Westernacher, J, Weygaert, R, Wiltshire, D, Wiseman, T, Wolf, P, Wu, K, Yamada, K, Yang, H, Yi, L, Yue, X, Yvon, D, Zilhão, M, Zimmerman, A, Zumalacarregui, M, Barausse, Enrico, Berti, Emanuele, Hertog, Thomas, Hughes, Scott A., Jetzer, Philippe, Pani, Paolo, Sotiriou, Thomas P., Tamanini, Nicola, Witek, Helvi, Yagi, Kent, Yunes, Nicolás, Abdelsalhin, T., Achucarro, A., van Aelst, K., Afshordi, N., Akcay, S., Annulli, L., Arun, K. G., Ayuso, I., Baibhav, V., Baker, T., Bantilan, H., Barreiro, T., Barrera-Hinojosa, C., Bartolo, N., Baumann, D., Belgacem, E., Bellini, E., Bellomo, N., Ben-Dayan, I., Bena, I., Benkel, R., Bergshoefs, E., Bernard, L., Bernuzzi, S., Bertacca, D., Besancon, M., Beutler, F., Beyer, F., Bhagwat, S., Bicak, J., Biondini, S., Bize, S., Blas, D., Boehmer, C., Boller, K., Bonga, B., Bonvin, C., Bosso, P., Bozzola, G., Brax, P., Breitbach, M., Brito, R., Bruni, M., Brügmann, B., Bulten, H., Buonanno, A., Burko, L. M., Burrage, C., Cabral, F., Calcagni, G., Caprini, C., Cárdenas-Avendaño, A., Celoria, M., Chatziioannou, K., Chernoff, D., Clough, K., Coates, A., Comelli, D., Compère, G., Croon, D., Cruces, D., Cusin, G., Dalang, C., Danielsson, U., Das, S., Datta, S., de Boer, J., De Luca, V., De Rham, C., Desjacques, V., Destounis, K., Filippo, F. Di, Dima, A., Dimastrogiovanni, E., Dolan, S., Doneva, D., Duque, F., Durrer, R., East, W., Easther, R., Elley, M., Ellis, J. R., Emparan, R., Ezquiaga, J. M., Fairbairn, M., Fairhurst, S., Farmer, H. F., Fasiello, M. R., Ferrari, V., Ferreira, P. G., Ficarra, G., Figueras, P., Fisenko, S., Foffa, S., Franchini, N., Franciolini, G., Fransen, K., Frauendiener, J., Frusciante, N., Fujita, R., Gair, J., Ganz, A., Garcia, P., Garcia-Bellido, J., Garriga, J., Geiger, R., Geng, C., Gergely, L. Á., Germani, C., Gerosa, D., Giddings, S. B., Gourgoulhon, E., Grandclement, P., Graziani, L., Gualtieri, L., Haggard, D., Haino, S., Halburd, R., Han, W. -B., Hawken, A. J., Hees, A., Heng, I. S., Hennig, J., Herdeiro, C., Hervik, S., Holten, J. v., Hoyle, C. J. D., Hu, Y., Hull, M., Ikeda, T., Isi, M., Jenkins, A., Julié, F., Kajfasz, E., Kalaghatgi, C., Kaloper, N., Kamionkowski, M., Karas, V., Kastha, S., Keresztes, Z., Kidder, L., Kimpson, T., Klein, A., Klioner, S., Kokkotas, K., Kolesova, H., Kolkowitz, S., Kopp, J., Koyama, K., Krishnendu, N. V., Kroon, J. A. V., Kunz, M., Lahav, O., Landragin, A., Lang, R. N., Poncin-Lafitte, C. Le, Lemos, J., Li, B., Liberati, S., Liguori, M., Lin, F., Liu, G., Lobo, F. S. N., Loll, R., Lombriser, L., Lovelace, G., Macedo, R. P., Madge, E., Maggio, E., Maggiore, M., Marassi, S., Marcoccia, P., Markakis, C., Martens, W., Martinovic, K., Martins, C. J. A. P., Maselli, A., Mastrogiovanni, S., Matarrese, S., Matas, A., Mavromatos, N. E., Mazumdar, A., Meerburg, P. D., Megias, E., Miller, J., Mimoso, J. P., Mittnacht, L., Montero, M. M., Moore, B., Martin-Moruno, P., Musco, I., Nakano, H., Nampalliwar, S., Nardini, G., Nielsen, A., Novák, J., Nunes, N. J., Okounkova, M., Oliveri, R., Oppizzi, F., Orlando, G., Oshita, N., Pappas, G., Paschalidis, V., Peiris, H., Peloso, M., Perkins, S., Pettorino, V., Pikovski, I., Pilo, L., Podolsky, J., Pontzen, A., Prabhat, S., Pratten, G., Prokopec, T., Prouza, M., Qi, H., Raccanelli, A., Rajantie, A., Randall, L., Raposo, G., Raymond, V., Renaux-Petel, S., Ricciardone, A., Riotto, A., Robson, T., Roest, D., Rollo, R., Rosofsky, S., Ruan, J. J., Rubiera-García, D., Ruiz, M., Rusu, M., Sabatie, F., Sago, N., Sakellariadou, M., Saltas, I. D., Sberna, L., Sathyaprakash, B., Scheel, M., Schmidt, P., Schutz, B., Schwaller, P., Shao, L., Shapiro, S. L., Shoemaker, D., Silva, A. d., Simpson, C., Sopuerta, C. F., Spallicci, A., Stefanek, B. A., Stein, L., Stergioulas, N., Stott, M., Sutton, P., Svarc, R., Tagoshi, H., Tahamtan, T., Takeda, H., Tanaka, T., Tantilian, G., Tasinato, G., Tattersall, O., Teukolsky, S., Tiec, A. L., Theureau, G., Trodden, M., Tolley, A., Toubiana, A., Traykova, D., Tsokaros, A., Unal, C., Unnikrishnan, C. S., Vagenas, E. C., Valageas, P., Vallisneri, M., Brand, J. Van den, Broeck, C. Van den, de Meent, M. van, Vanhove, P., Varma, V., Veitch, J., Vercnocke, B., Verde, L., Vernieri, D., Vernizzi, F., Vicente, R., Vidotto, F., Visser, M., Vlah, Z., Vretinaris, S., Völkel, S., Wang, Q., Wang, Yu-Tong, Werner, M. C., Westernacher, J., Weygaert, R. v. d., Wiltshire, D., Wiseman, T., Wolf, P., Wu, K., Yamada, K., Yang, H., Yi, L., Yue, X., Yvon, D., Zilhão, M., Zimmerman, A., and Zumalacarregui, M.

Abstract

In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA, we present here a sample of what we view as particularly promising directions, based in part on the current research interests of the LISA scientific community in the area of fundamental physics. We organize these directions through a "science-first" approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics.

Published
2020

20. Advances in Neonatal Care: 20 Years, 1445 Manuscripts, and Countless Nurses Touched and Infants Impacted!

Author

Madge E Buus-Frank

Subjects
Adult, Male, Research Report, medicine.medical_specialty, Nurses, Neonatal, business.industry, Infant, Newborn, MEDLINE, Infant, General Medicine, History, 20th Century, Middle Aged, History, 21st Century, United States, Intensive Care Units, Neonatal, Neonatal Nursing, Family medicine, Pediatrics, Perinatology and Child Health, medicine, Humans, Female, business, Forecasting
Published
2020
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21. Spreading routine serious illness conversations at a single cancer center using a multidisciplinary and patient-family advisory approach

Author

Garrett Thomas Wasp, Karen Guo, Matthew Wilson, Maxwell Thomas Vergo, Andy Willaims, James J. Perry, Megan M. Holthoff, Madge E. Buus-Frank, and Amelia M. Cullinan

Subjects
Cancer Research, Oncology
Abstract

367 Background: ASCO Guidelines recommend oncologists conduct serious illness conservations (SIC) for all patients with advanced cancer. We describe the spreading of a multidisciplinary and patient-family advisor (PFA) quality improvement (QI) initiative to conduct routine SIC at a NCI-designated comprehensive cancer center. Methods: This single center study describes the second phase of a learning health system initiative to conduct routine SIC for all seriously ill patients with cancer. Prior work completed included defining patient eligibility (e.g. two-year surprise question), and deploying a SIC template in the electronic health record (EHR) to capture SIC in a centralized location. Phase II can be categorized into three steps: a) increasing communication coach and PFA capacity; b) refining EHR tools to automate tracking and reporting of outcomes; and c) adoption of the Model for Improvement as the QI methodology to guide testing and implementation. For the first three months, each team engaged in preparatory work including: process mapping, key driver diagram development, and SIC Guide training. In the last six months, each team met weekly to set their own team goals, conducted iterative PDSAs, and reviewed run charts of their performance. Patient-level data on SIC documentation was collected through automated EHR tools and provided to the teams on a weekly basis. Results: Over nine months (3/1/2021 to 12/31/21), four teams screened 510 patients with cancer, identified 272 (53%) patients as eligible for SIC, and 178 (65%) of those eligible had a documented SIC from a baseline of 0%. The breakdown of this combined SIC patient count by clinician author is as follows: team A 40 (22%); team B 45 (25%); team C 9 (5%); team D 14 (8%) and specialty palliative care 70 (39%). Each team set modest, initial SIC documentation goals (range 5-15%), and attainment of first SIC documentation goal varied (range 2 to 4 months). We retained all clinician team members during the study period, but 2 out of 3 PFAs left by study period end. Noted challenges with PFA recruitment and retention included: lengthy recruitment, integration into clinical teams, and resistance to change by teams. Conclusions: The multidisciplinary approach, inclusive of specialty palliative care, increased SIC documentation. PFA involvement, as implemented, met with challenges and yielded mixed results. Additional follow-up will be required to assess if gains can be sustained and/or increased.

Published
2022
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24. Prioritizing Measures That Matter Within a Person-Centered Oncology Learning Health System.

Author

Citters, Aricca D Van, Kennedy, Alice M, Kirkland, Kathryn B, Dragnev, Konstantin H, Leach, Steven D, Buus-Frank, Madge E, Malcolm, Elissa F, Holthoff, Megan M, Holmes, Anne B, Nelson, Eugene C, Reeves, Susan A, Tosteson, Anna N A, and Panel, the Promise Partnership Delphi

Subjects
ONCOLOGY, HEALTH systems agencies, CANCER
Abstract

Background Despite progress in developing learning health systems (LHS) and associated metrics of success, a gap remains in identifying measures to guide the implementation and assessment of the impact of an oncology LHS. Our aim was to identify a balanced set of measures to guide a person-centered oncology LHS. Methods A modified Delphi process and clinical value compass framework were used to prioritize measures for tracking LHS performance. A multidisciplinary group of 77 stakeholders, including people with cancer and family members, participated in 3 rounds of online voting followed by 50-minute discussions. Participants rated metrics on perceived importance to the LHS and discussed priorities. Results Voting was completed by 94% of participants and prioritized 22 measures within 8 domains. Patient and caregiver factors included clinical health (Eastern Cooperative Oncology Group Performance Status, survival by cancer type and stage), functional health and quality of life (Patient Reported Outcomes Measurement Information System [PROMIS] Global-10, Distress Thermometer, Modified Caregiver Strain Index), experience of care (advance care planning, collaboRATE, PROMIS Self-Efficacy Scale, access to care, experience of care, end-of-life quality measures), and cost and resource use (avoidance and delay in accessing care and medications, financial hardship, total cost of care). Contextual factors included team well-being (Well-being Index; voluntary staff turnover); learning culture (Improvement Readiness, compliance with Commission on Cancer quality of care measures); scholarly engagement and productivity (institutional commitment and support for research, academic productivity index); and diversity, equity, inclusion, and belonging (screening and follow-up for social determinants of health, inclusivity of staff and patients). Conclusions The person-centered LHS value compass provides a balanced set of measures that oncology practices can use to monitor and evaluate improvement across multiple domains. [ABSTRACT FROM AUTHOR]

Published
2022
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27. Prospects for fundamental physics with LISA

Author

Barausse, Enrico, primary, Berti, Emanuele, additional, Hertog, Thomas, additional, Hughes, Scott A., additional, Jetzer, Philippe, additional, Pani, Paolo, additional, Sotiriou, Thomas P., additional, Tamanini, Nicola, additional, Witek, Helvi, additional, Yagi, Kent, additional, Yunes, Nicolás, additional, Abdelsalhin, T., additional, Achucarro, A., additional, van Aelst, K., additional, Afshordi, N., additional, Akcay, S., additional, Annulli, L., additional, Arun, K. G., additional, Ayuso, I., additional, Baibhav, V., additional, Baker, T., additional, Bantilan, H., additional, Barreiro, T., additional, Barrera-Hinojosa, C., additional, Bartolo, N., additional, Baumann, D., additional, Belgacem, E., additional, Bellini, E., additional, Bellomo, N., additional, Ben-Dayan, I., additional, Bena, I., additional, Benkel, R., additional, Bergshoefs, E., additional, Bernard, L., additional, Bernuzzi, S., additional, Bertacca, D., additional, Besancon, M., additional, Beutler, F., additional, Beyer, F., additional, Bhagwat, S., additional, Bicak, J., additional, Biondini, S., additional, Bize, S., additional, Blas, D., additional, Boehmer, C., additional, Boller, K., additional, Bonga, B., additional, Bonvin, C., additional, Bosso, P., additional, Bozzola, G., additional, Brax, P., additional, Breitbach, M., additional, Brito, R., additional, Bruni, M., additional, Brügmann, B., additional, Bulten, H., additional, Buonanno, A., additional, Burko, L. M., additional, Burrage, C., additional, Cabral, F., additional, Calcagni, G., additional, Caprini, C., additional, Cárdenas-Avendaño, A., additional, Celoria, M., additional, Chatziioannou, K., additional, Chernoff, D., additional, Clough, K., additional, Coates, A., additional, Comelli, D., additional, Compère, G., additional, Croon, D., additional, Cruces, D., additional, Cusin, G., additional, Dalang, C., additional, Danielsson, U., additional, Das, S., additional, Datta, S., additional, de Boer, J., additional, De Luca, V., additional, De Rham, C., additional, Desjacques, V., additional, Destounis, K., additional, Filippo, F. Di, additional, Dima, A., additional, Dimastrogiovanni, E., additional, Dolan, S., additional, Doneva, D., additional, Duque, F., additional, Durrer, R., additional, East, W., additional, Easther, R., additional, Elley, M., additional, Ellis, J. R., additional, Emparan, R., additional, Ezquiaga, J. M., additional, Fairbairn, M., additional, Fairhurst, S., additional, Farmer, H. F., additional, Fasiello, M. R., additional, Ferrari, V., additional, Ferreira, P. G., additional, Ficarra, G., additional, Figueras, P., additional, Fisenko, S., additional, Foffa, S., additional, Franchini, N., additional, Franciolini, G., additional, Fransen, K., additional, Frauendiener, J., additional, Frusciante, N., additional, Fujita, R., additional, Gair, J., additional, Ganz, A., additional, Garcia, P., additional, Garcia-Bellido, J., additional, Garriga, J., additional, Geiger, R., additional, Geng, C., additional, Gergely, L. Á., additional, Germani, C., additional, Gerosa, D., additional, Giddings, S. B., additional, Gourgoulhon, E., additional, Grandclement, P., additional, Graziani, L., additional, Gualtieri, L., additional, Haggard, D., additional, Haino, S., additional, Halburd, R., additional, Han, W.-B., additional, Hawken, A. J., additional, Hees, A., additional, Heng, I. S., additional, Hennig, J., additional, Herdeiro, C., additional, Hervik, S., additional, Holten, J. v., additional, Hoyle, C. J. D., additional, Hu, Y., additional, Hull, M., additional, Ikeda, T., additional, Isi, M., additional, Jenkins, A., additional, Julié, F., additional, Kajfasz, E., additional, Kalaghatgi, C., additional, Kaloper, N., additional, Kamionkowski, M., additional, Karas, V., additional, Kastha, S., additional, Keresztes, Z., additional, Kidder, L., additional, Kimpson, T., additional, Klein, A., additional, Klioner, S., additional, Kokkotas, K., additional, Kolesova, H., additional, Kolkowitz, S., additional, Kopp, J., additional, Koyama, K., additional, Krishnendu, N. V., additional, Kroon, J. A. V., additional, Kunz, M., additional, Lahav, O., additional, Landragin, A., additional, Lang, R. N., additional, Poncin-Lafitte, C. Le, additional, Lemos, J., additional, Li, B., additional, Liberati, S., additional, Liguori, M., additional, Lin, F., additional, Liu, G., additional, Lobo, F. S. N., additional, Loll, R., additional, Lombriser, L., additional, Lovelace, G., additional, Macedo, R. P., additional, Madge, E., additional, Maggio, E., additional, Maggiore, M., additional, Marassi, S., additional, Marcoccia, P., additional, Markakis, C., additional, Martens, W., additional, Martinovic, K., additional, Martins, C. J. A. P., additional, Maselli, A., additional, Mastrogiovanni, S., additional, Matarrese, S., additional, Matas, A., additional, Mavromatos, N. E., additional, Mazumdar, A., additional, Meerburg, P. D., additional, Megias, E., additional, Miller, J., additional, Mimoso, J. P., additional, Mittnacht, L., additional, Montero, M. M., additional, Moore, B., additional, Martin-Moruno, P., additional, Musco, I., additional, Nakano, H., additional, Nampalliwar, S., additional, Nardini, G., additional, Nielsen, A., additional, Novák, J., additional, Nunes, N. J., additional, Okounkova, M., additional, Oliveri, R., additional, Oppizzi, F., additional, Orlando, G., additional, Oshita, N., additional, Pappas, G., additional, Paschalidis, V., additional, Peiris, H., additional, Peloso, M., additional, Perkins, S., additional, Pettorino, V., additional, Pikovski, I., additional, Pilo, L., additional, Podolsky, J., additional, Pontzen, A., additional, Prabhat, S., additional, Pratten, G., additional, Prokopec, T., additional, Prouza, M., additional, Qi, H., additional, Raccanelli, A., additional, Rajantie, A., additional, Randall, L., additional, Raposo, G., additional, Raymond, V., additional, Renaux-Petel, S., additional, Ricciardone, A., additional, Riotto, A., additional, Robson, T., additional, Roest, D., additional, Rollo, R., additional, Rosofsky, S., additional, Ruan, J. J., additional, Rubiera-García, D., additional, Ruiz, M., additional, Rusu, M., additional, Sabatie, F., additional, Sago, N., additional, Sakellariadou, M., additional, Saltas, I. D., additional, Sberna, L., additional, Sathyaprakash, B., additional, Scheel, M., additional, Schmidt, P., additional, Schutz, B., additional, Schwaller, P., additional, Shao, L., additional, Shapiro, S. L., additional, Shoemaker, D., additional, Silva, A. d., additional, Simpson, C., additional, Sopuerta, C. F., additional, Spallicci, A., additional, Stefanek, B. A., additional, Stein, L., additional, Stergioulas, N., additional, Stott, M., additional, Sutton, P., additional, Svarc, R., additional, Tagoshi, H., additional, Tahamtan, T., additional, Takeda, H., additional, Tanaka, T., additional, Tantilian, G., additional, Tasinato, G., additional, Tattersall, O., additional, Teukolsky, S., additional, Tiec, A. L., additional, Theureau, G., additional, Trodden, M., additional, Tolley, A., additional, Toubiana, A., additional, Traykova, D., additional, Tsokaros, A., additional, Unal, C., additional, Unnikrishnan, C. S., additional, Vagenas, E. C., additional, Valageas, P., additional, Vallisneri, M., additional, Brand, J. Van den, additional, Broeck, C. Van den, additional, de Meent, M. van, additional, Vanhove, P., additional, Varma, V., additional, Veitch, J., additional, Vercnocke, B., additional, Verde, L., additional, Vernieri, D., additional, Vernizzi, F., additional, Vicente, R., additional, Vidotto, F., additional, Visser, M., additional, Vlah, Z., additional, Vretinaris, S., additional, Völkel, S., additional, Wang, Q., additional, Wang, Yu-Tong, additional, Werner, M. C., additional, Westernacher, J., additional, Weygaert, R. v. d., additional, Wiltshire, D., additional, Wiseman, T., additional, Wolf, P., additional, Wu, K., additional, Yamada, K., additional, Yang, H., additional, Yi, L., additional, Yue, X., additional, Yvon, D., additional, Zilhão, M., additional, Zimmerman, A., additional, and Zumalacarregui, M., additional

Published
2020
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30. A Collaborative Multicenter QI Initiative to Improve Antibiotic Stewardship in Newborns

Author

Donald A. Goldmann, Roger F. Soll, Karen M. Puopolo, John A.F. Zupancic, Madge E. Buus-Frank, Erika M. Edwards, DeWayne M. Pursley, Jeffrey D. Horbar, Kate A. Morrow, Timmy Ho, Dmitry Dukhovny, Arjun Srinivasan, and Daniel A. Pollock

Subjects
Male, medicine.medical_specialty, Quality management, MEDLINE, Audit, Coaching, Antimicrobial Stewardship, 03 medical and health sciences, 0302 clinical medicine, Intensive Care Units, Neonatal, 030225 pediatrics, medicine, Humans, Antimicrobial stewardship, Intersectoral Collaboration, Quality Indicators, Health Care, Medical Audit, business.industry, Infant, Newborn, Vermont oxford network, Quality Improvement, Disease control, Family medicine, Pediatrics, Perinatology and Child Health, Antibiotic Stewardship, Female, business
Abstract

OBJECTIVES: To determine if NICU teams participating in a multicenter quality improvement (QI) collaborative achieve increased compliance with the Centers for Disease Control and Prevention (CDC) core elements for antibiotic stewardship and demonstrate reductions in antibiotic use (AU) among newborns. METHODS: From January 2016 to December 2017, multidisciplinary teams from 146 NICUs participated in Choosing Antibiotics Wisely, an Internet-based national QI collaborative conducted by the Vermont Oxford Network consisting of interactive Web sessions, a series of 4 point-prevalence audits, and expert coaching designed to help teams test and implement the CDC core elements of antibiotic stewardship. The audits assessed unit-level adherence to the CDC core elements and collected patient-level data about AU. The AU rate was defined as the percentage of infants in the NICU receiving 1 or more antibiotics on the day of the audit. RESULTS: The percentage of NICUs implementing the CDC core elements increased in each of the 7 domains (leadership: 15.4%–68.8%; accountability: 54.5%–95%; drug expertise: 61.5%–85.1%; actions: 21.7%–72.3%; tracking: 14.7%–78%; reporting: 6.3%–17.7%; education: 32.9%–87.2%; P < .005 for all measures). The median AU rate decreased from 16.7% to 12.1% (P for trend < .0013), a 34% relative risk reduction. CONCLUSIONS: NICU teams participating in this QI collaborative increased adherence to the CDC core elements of antibiotic stewardship and achieved significant reductions in AU.

Published
2019
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31. Discovering the h → Zγ Decay in tt Associated Production

Author

Goertz, F., Madge, E., Schwaller, P., and Tenorth, V.

Subjects
High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

We explore the prospects to discover the $h \to Z \gamma$ decay in $t\bar t$-associated production, featuring a signal-to-background ratio of ${\cal O}(1)$. Performing a detailed analysis of the semi-leptonic $t \bar t $-decay channel, we demonstrate that the production mode could lead to a $\sim5\,\sigma$ discovery at the high-luminosity LHC, while the effective $h Z \gamma$ coupling could be extracted with a $\sim15\,\%$ accuracy. Extending the analysis to potential future $pp$ colliders with 27 TeV and 100 TeV center-of-mass energies, we also show that the latter would allow precision measurements at the few percent level, rendering possible precise extractions of the spin and CP properties of the Higgs boson.

Published
2019

32. Using NHSN's Antimicrobial Use Option to Monitor and Improve Antibiotic Stewardship in Neonates

Author

Judith A. Guzman-Cottrill, Jessica Roberts, Jonathan R. Edwards, Melinda M. Neuhauser, Madge E. Buus-Frank, Grace M. Lee, Katharina L. van Santen, Erika M. Edwards, Amy K Webb, Daniel A. Pollock, Arjun Srinivasan, Jeffrey D. Horbar, David Braun, Edward Septimus, Roger F. Soll, Erin O’Leary, and Joseph Schulman

Subjects
Psychological intervention, MEDLINE, Pediatrics, Article, 03 medical and health sciences, Antimicrobial Stewardship, 0302 clinical medicine, 030225 pediatrics, Health care, Drug Resistance, Bacterial, Antimicrobial stewardship, Medicine, Humans, 030212 general & internal medicine, business.industry, Health services research, Infant, Newborn, General Medicine, Bacterial Infections, medicine.disease, United States, Anti-Bacterial Agents, Antimicrobial use, Pediatrics, Perinatology and Child Health, Antibiotic Stewardship, Stewardship, Medical emergency, Health Services Research, Centers for Disease Control and Prevention, U.S, business
Abstract

BACKGROUND: The Antimicrobial Use (AU) Option of the Centers for Disease Control and Prevention’s National Healthcare Safety Network (NHSN) is a surveillance resource that can provide actionable data for antibiotic stewardship programs. Such data are used to enable measurements of AU across hospitals and before, during, and after stewardship interventions. METHODS: We used monthly AU data and annual facility survey data submitted to the NHSN to describe hospitals and neonatal patient care locations reporting to the AU Option in 2017, examine frequencies of most commonly reported agents, and analyze variability in AU rates across hospitals and levels of care. We used results from these analyses in a collaborative project with Vermont Oxford Network to develop neonatal-specific Standardized Antimicrobial Administration Ratio (SAAR) agent categories and neonatal-specific NHSN Annual Hospital Survey questions. RESULTS: As of April 1, 2018, 351 US hospitals had submitted data to the AU Option from at least 1 neonatal unit. In 2017, ampicillin and gentamicin were the most frequently reported antimicrobial agents. On average, total rates of AU were highest in level III NICUs, followed by special care nurseries, level II-III NICUs, and well newborn nurseries. Seven antimicrobial categories for neonatal SAARs were created, and 6 annual hospital survey questions were developed. CONCLUSIONS: A small but growing percentage of US hospitals have submitted AU data from neonatal patient care locations to NHSN, enabling the use of AU data aggregated by NHSN as benchmarks for neonatal antimicrobial stewardship programs and further development of the SAAR summary measure for neonatal AU.

Published
2019

33. Prospects for fundamental physics with LISA

Author

Theoretical Physics, Sub NMR Spectroscopy, LS Immunologie, Afd Subatomic Physics (SAP), Afd OT Educatie en pedagogiek, Sub General Pharmaceutics, Sub RvdM overig, Sub String Theory Cosmology and ElemPart, Dep Natuurkunde, Sub Inorganic Chemistry and Catalysis, LS Wijsgerige Ethiek, Section Geography and Education, Barausse, Enrico, Berti, Emanuele, Hertog, Thomas, Hughes, Scott A., Jetzer, Philippe, Pani, Paolo, Sotiriou, Thomas P., Tamanini, Nicola, Witek, Helvi, Yagi, Kent, Yunes, Nicolas, Abdelsalhin, T., Achucarro, A., van Aelst, K., Afshordi, N., Akcay, S., Annulli, L., Arun, K. G., Ayuso, I., Baibhav, V., Baker, T., Bantilan, H., Barreiro, T., Barrera-Hinojosa, C., Bartolo, N., Baumann, D., Belgacem, E., Bellini, E., Bellomo, N., Ben-Dayan, I., Bena, I., Benkel, R., Bergshoefs, E., Bernard, L., Bernuzzi, S., Bertacca, D., Besancon, M., Beutler, F., Beyer, F., Bhagwat, S., Bicak, J., Biondini, S., Bize, S., Blas, D., Boehmer, C., Boller, K., Bonga, B., Bonvin, C., Bosso, P., Bozzola, G., Brax, P., Breitbach, M., Brito, R., Bruni, M., Bruegmann, B., Bulten, H., Buonanno, A., Burko, L. M., Burrage, C., Cabral, F., Calcagni, G., Caprini, C., Cardenas-Avendano, A., Celoria, M., Chatziioannou, K., Chernoff, D., Clough, K., Coates, A., Comelli, D., Compere, G., Croon, D., Cruces, D., Cusin, G., Dalang, C., Danielsson, U., Das, S., Datta, S., de Boer, J., De Luca, V., De Rham, C., Desjacques, V., Destounis, K., Filippo, F. Di, Dima, A., Dimastrogiovanni, E., Dolan, S., Doneva, D., Duque, F., Durrer, R., East, W., Easther, R., Elley, M., Ellis, J. R., Emparan, R., Ezquiaga, J. M., Fairbairn, M., Fairhurst, S., Farmer, H. F., Fasiello, M. R., Ferrari, V., Ferreira, P. G., Ficarra, G., Figueras, P., Fisenko, S., Foffa, S., Franchini, N., Franciolini, G., Fransen, K., Frauendiener, J., Frusciante, N., Fujita, R., Gair, J., Ganz, A., Garcia, P., Garcia-Bellido, J., Garriga, J., Geiger, R., Geng, C., Gergely, L. a., Germani, C., Gerosa, D., Giddings, S. B., Gourgoulhon, E., Grandclement, P., Graziani, L., Gualtieri, L., Haggard, D., Haino, S., Halburd, R., Han, W. -B., Hawken, A. J., Hees, A., Heng, I. S., Hennig, J., Herdeiro, C., Hervik, S., Holten, J. v., Hoyle, C. D., Hu, Y., Hull, M., Ikeda, T., Isi, M., Jenkins, A., Julie, F., Kajfasz, E., Kalaghatgi, C., Kaloper, N., Kamionkowski, M., Karas, V., Kastha, S., Keresztes, Z., Kidder, L., Kimpson, T., Klein, A., Klioner, S., Kokkotas, K., Kolesova, H., Kolkowitz, S., Kopp, J., Koyama, K., Krishnendu, N. V., Kroon, J. A. V., Kunz, M., Lahav, O., Landragin, A., Lang, R. N., Poncin-Lafitte, C. Le, Lemos, J., Li, B., Liberati, S., Liguori, M., Lin, F., Liu, G., Lobo, F. S. N., Loll, R., Lombriser, L., Lovelace, G., Macedo, R. P., Madge, E., Maggio, E., Maggiore, M., Marassi, S., Marcoccia, P., Markakis, C., Martens, W., Martinovic, K., Martins, C. J. A. P., Maselli, A., Mastrogiovanni, S., Matarrese, S., Matas, A., Mavromatos, N. E., Mazumdar, A., Meerburg, P. D., Megias, E., Miller, J., Mimoso, J. P., Mittnacht, L., Montero, M. M., Moore, B., Martin-Moruno, P., Musco, I., Nakano, H., Nampalliwar, S., Nardini, G., Nielsen, A., Novak, J., Nunes, N. J., Okounkova, M., Oliveri, R., Oppizzi, F., Orlando, G., Oshita, N., Pappas, G., Paschalidis, V., Peiris, H., Peloso, M., Perkins, S., Pettorino, V., Pikovski, I., Pilo, L., Podolsky, J., Pontzen, A., Prabhat, S., Pratten, G., Prokopec, T., Prouza, M., Qi, H., Raccanelli, A., Rajantie, A., Randall, L., Raposo, G., Raymond, V., Renaux-Petel, S., Ricciardone, A., Riotto, A., Robson, T., Roest, D., Rollo, R., Rosofsky, S., Ruan, J. J., Rubiera-Garcia, D., Ruiz, M., Rusu, M., Sabatie, F., Sago, N., Sakellariadou, M., Saltas, I. D., Sberna, L., Sathyaprakash, B., Scheel, M., Schmidt, P., Schutz, B., Schwaller, P., Shao, L., Shapiro, S. L., Shoemaker, D., Silva, A. d., Simpson, C., Sopuerta, C. F., Spallicci, A., Stefanek, B. A., Stein, L., Stergioulas, N., Stott, M., Sutton, P., Svarc, R., Tagoshi, H., Tahamtan, T., Takeda, H., Tanaka, T., Tantilian, G., Tasinato, G., Tattersall, O., Teukolsky, S., Tiec, A. L., Theureau, G., Trodden, M., Tolley, A., Toubiana, A., Traykova, D., Tsokaros, A., Unal, C., Unnikrishnan, C. S., Vagenas, E. C., Valageas, P., Vallisneri, M., Brand, J. Van den, Broeck, C. Van den, de Meent, M. van, Vanhove, P., Varma, V., Veitch, J., Vercnocke, B., Verde, L., Vernieri, D., Vernizzi, F., Vicente, R., Vidotto, F., Visser, M., Vlah, Z., Vretinaris, S., Voelkel, S., Wang, Q., Wang, Yu-Tong, Werner, M. C., Westernacher, J., Weygaert, R. v. d., Wiltshire, D., Wiseman, T., Wolf, P., Wu, K., Yamada, K., Yang, H., Yi, L., Yue, X., Yvon, D., Zilhao, M., Zimmerman, A., Zumalacarregui, M., Theoretical Physics, Sub NMR Spectroscopy, LS Immunologie, Afd Subatomic Physics (SAP), Afd OT Educatie en pedagogiek, Sub General Pharmaceutics, Sub RvdM overig, Sub String Theory Cosmology and ElemPart, Dep Natuurkunde, Sub Inorganic Chemistry and Catalysis, LS Wijsgerige Ethiek, Section Geography and Education, Barausse, Enrico, Berti, Emanuele, Hertog, Thomas, Hughes, Scott A., Jetzer, Philippe, Pani, Paolo, Sotiriou, Thomas P., Tamanini, Nicola, Witek, Helvi, Yagi, Kent, Yunes, Nicolas, Abdelsalhin, T., Achucarro, A., van Aelst, K., Afshordi, N., Akcay, S., Annulli, L., Arun, K. G., Ayuso, I., Baibhav, V., Baker, T., Bantilan, H., Barreiro, T., Barrera-Hinojosa, C., Bartolo, N., Baumann, D., Belgacem, E., Bellini, E., Bellomo, N., Ben-Dayan, I., Bena, I., Benkel, R., Bergshoefs, E., Bernard, L., Bernuzzi, S., Bertacca, D., Besancon, M., Beutler, F., Beyer, F., Bhagwat, S., Bicak, J., Biondini, S., Bize, S., Blas, D., Boehmer, C., Boller, K., Bonga, B., Bonvin, C., Bosso, P., Bozzola, G., Brax, P., Breitbach, M., Brito, R., Bruni, M., Bruegmann, B., Bulten, H., Buonanno, A., Burko, L. M., Burrage, C., Cabral, F., Calcagni, G., Caprini, C., Cardenas-Avendano, A., Celoria, M., Chatziioannou, K., Chernoff, D., Clough, K., Coates, A., Comelli, D., Compere, G., Croon, D., Cruces, D., Cusin, G., Dalang, C., Danielsson, U., Das, S., Datta, S., de Boer, J., De Luca, V., De Rham, C., Desjacques, V., Destounis, K., Filippo, F. Di, Dima, A., Dimastrogiovanni, E., Dolan, S., Doneva, D., Duque, F., Durrer, R., East, W., Easther, R., Elley, M., Ellis, J. R., Emparan, R., Ezquiaga, J. M., Fairbairn, M., Fairhurst, S., Farmer, H. F., Fasiello, M. R., Ferrari, V., Ferreira, P. G., Ficarra, G., Figueras, P., Fisenko, S., Foffa, S., Franchini, N., Franciolini, G., Fransen, K., Frauendiener, J., Frusciante, N., Fujita, R., Gair, J., Ganz, A., Garcia, P., Garcia-Bellido, J., Garriga, J., Geiger, R., Geng, C., Gergely, L. a., Germani, C., Gerosa, D., Giddings, S. B., Gourgoulhon, E., Grandclement, P., Graziani, L., Gualtieri, L., Haggard, D., Haino, S., Halburd, R., Han, W. -B., Hawken, A. J., Hees, A., Heng, I. S., Hennig, J., Herdeiro, C., Hervik, S., Holten, J. v., Hoyle, C. D., Hu, Y., Hull, M., Ikeda, T., Isi, M., Jenkins, A., Julie, F., Kajfasz, E., Kalaghatgi, C., Kaloper, N., Kamionkowski, M., Karas, V., Kastha, S., Keresztes, Z., Kidder, L., Kimpson, T., Klein, A., Klioner, S., Kokkotas, K., Kolesova, H., Kolkowitz, S., Kopp, J., Koyama, K., Krishnendu, N. V., Kroon, J. A. V., Kunz, M., Lahav, O., Landragin, A., Lang, R. N., Poncin-Lafitte, C. Le, Lemos, J., Li, B., Liberati, S., Liguori, M., Lin, F., Liu, G., Lobo, F. S. N., Loll, R., Lombriser, L., Lovelace, G., Macedo, R. P., Madge, E., Maggio, E., Maggiore, M., Marassi, S., Marcoccia, P., Markakis, C., Martens, W., Martinovic, K., Martins, C. J. A. P., Maselli, A., Mastrogiovanni, S., Matarrese, S., Matas, A., Mavromatos, N. E., Mazumdar, A., Meerburg, P. D., Megias, E., Miller, J., Mimoso, J. P., Mittnacht, L., Montero, M. M., Moore, B., Martin-Moruno, P., Musco, I., Nakano, H., Nampalliwar, S., Nardini, G., Nielsen, A., Novak, J., Nunes, N. J., Okounkova, M., Oliveri, R., Oppizzi, F., Orlando, G., Oshita, N., Pappas, G., Paschalidis, V., Peiris, H., Peloso, M., Perkins, S., Pettorino, V., Pikovski, I., Pilo, L., Podolsky, J., Pontzen, A., Prabhat, S., Pratten, G., Prokopec, T., Prouza, M., Qi, H., Raccanelli, A., Rajantie, A., Randall, L., Raposo, G., Raymond, V., Renaux-Petel, S., Ricciardone, A., Riotto, A., Robson, T., Roest, D., Rollo, R., Rosofsky, S., Ruan, J. J., Rubiera-Garcia, D., Ruiz, M., Rusu, M., Sabatie, F., Sago, N., Sakellariadou, M., Saltas, I. D., Sberna, L., Sathyaprakash, B., Scheel, M., Schmidt, P., Schutz, B., Schwaller, P., Shao, L., Shapiro, S. L., Shoemaker, D., Silva, A. d., Simpson, C., Sopuerta, C. F., Spallicci, A., Stefanek, B. A., Stein, L., Stergioulas, N., Stott, M., Sutton, P., Svarc, R., Tagoshi, H., Tahamtan, T., Takeda, H., Tanaka, T., Tantilian, G., Tasinato, G., Tattersall, O., Teukolsky, S., Tiec, A. L., Theureau, G., Trodden, M., Tolley, A., Toubiana, A., Traykova, D., Tsokaros, A., Unal, C., Unnikrishnan, C. S., Vagenas, E. C., Valageas, P., Vallisneri, M., Brand, J. Van den, Broeck, C. Van den, de Meent, M. van, Vanhove, P., Varma, V., Veitch, J., Vercnocke, B., Verde, L., Vernieri, D., Vernizzi, F., Vicente, R., Vidotto, F., Visser, M., Vlah, Z., Vretinaris, S., Voelkel, S., Wang, Q., Wang, Yu-Tong, Werner, M. C., Westernacher, J., Weygaert, R. v. d., Wiltshire, D., Wiseman, T., Wolf, P., Wu, K., Yamada, K., Yang, H., Yi, L., Yue, X., Yvon, D., Zilhao, M., Zimmerman, A., and Zumalacarregui, M.

Published
2020

36. Alarm safety and oxygen saturation targets in the Vermont Oxford Network iNICQ 2015 collaborative

Author

Roger F. Soll, David W. Sink, James I. Hagadorn, Jeffrey D. Horbar, Madge E. Buus-Frank, Kate A. Morrow, Erika M. Edwards, and Karla R. Ferrelli

Subjects
medicine.medical_specialty, Gestational Age, Commission, Audit, Hyperoxia, Local policy, 03 medical and health sciences, ALARM, Patient safety, 0302 clinical medicine, Intensive Care Units, Neonatal, 030225 pediatrics, Intensive care, medicine, Humans, Oximetry, Prospective Studies, 030212 general & internal medicine, Hypoxia, Intensive care medicine, Monitoring, Physiologic, Oxygen saturation (medicine), business.industry, Infant, Newborn, Obstetrics and Gynecology, Vermont oxford network, medicine.disease, Oxygen, Logistic Models, Clinical Alarms, Pediatrics, Perinatology and Child Health, Patient Safety, Medical emergency, business, Infant, Premature, Vermont
Abstract

To assess progress of neonatal intensive care units (NICUs) participating in the Vermont Oxford Network iNICQ 2015: Alarm Safety Collaborative in achieving Joint Commission 2014 alarm safety goals with respect to oximeters, and to compare patient-level oxygen saturation (SpO2) and oximeter alarm data to local policies. Prospective multicenter audits in February and August 2015 assessed implementation of policies addressing Joint Commission 2014 Alarm Safety goals, and ascertained SpO2 targets, oximeter alarm settings and compliance with policy-specified SpO2 targets and alarms. Eighty-six NICUs completed both audits. Of 13 policies addressing mandated goals, median (interquartile range) 8 (5, 9) policies were implemented at audit 1 and 9 (6, 11) at audit 2 (P=0.004). At audit 1, 28 NICUs had implemented ⩾9 policies versus 47 at audit 2. For 794 infants 97% was less frequent than when high alarm was not set to policy (10.1% vs 21.5%, P=0.006). Participating NICUs showed significant progress between audits in their implementation of Joint Commission Alarm Safety goals for oximeter monitoring. Oximeter high alarm not set per local policy is associated with increased hyperoxemia in preterm infants. Recommendations to standardize oxygen saturation targets for infants at risk for oxygenation-related outcomes have not been widely adopted.

Published
2016
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37. Non-pharmacological care for opioid withdrawal in newborns

Author

Leslie Young, Madge E. Buus-Frank, Roger F. Soll, Adrienne Pahl, and Leonora Marcellus

Subjects
Medicine General & Introductory Medical Sciences, Narcotics, Pediatrics, medicine.medical_specialty, Neonatal intensive care unit, Population, Beds, Patient Positioning, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Intensive Care Units, Neonatal, 030225 pediatrics, Opiate Substitution Treatment, Prone Position, Humans, Hypnotics and Sedatives, Medicine, Pharmacology (medical), 030212 general & internal medicine, education, Randomized Controlled Trials as Topic, education.field_of_study, business.industry, Infant Equipment, Infant, Newborn, Length of Stay, Clinical trial, Breast Feeding, Opioid, Meta-analysis, Relative risk, Environment Design, Nurseries, Infant, business, Neonatal Abstinence Syndrome, Breast feeding, medicine.drug
Abstract

Background The prevalence of substance use, both prescribed and non-prescribed, is increasing in many areas of the world. Substance use by women of childbearing age contributes to increasing rates of neonatal abstinence syndrome (NAS). Neonatal opioid withdrawal syndrome (NOWS) is a newer term describing the subset of NAS related to opioid exposure. Non-pharmacological care is the first-line treatment for substance withdrawal in newborns. Despite the widespread use of non-pharmacological care to mitigate symptoms of NAS, there is not an established definition of, and standard for, non-pharmacological care practices in this population. Evaluation of safety and efficacy of non-pharmacological practices could provide clear guidance for clinical practice. Objectives To evaluate the safety and efficacy of non-pharmacological treatment of infants at risk for, or having symptoms consistent with, opioid withdrawal on the length of hospitalization and use of pharmacological treatment for symptom management. Comparison 1: in infants at risk for, or having early symptoms consistent with, opioid withdrawal, does non-pharmacological treatment reduce the length of hospitalization and use of pharmacological treatment? Comparison 2: in infants receiving pharmacological treatment for symptoms consistent with opioid withdrawal, does concurrent non-pharmacological treatment reduce duration of pharmacological treatment, maximum and cumulative doses of opioid medication, and length of hospitalization? Search methods We used the standard search strategy of Cochrane Neonatal to search CENTRAL (2019, Issue 10); Ovid MEDLINE; and CINAHL on 11 October 2019. We also searched clinical trials databases and the reference lists of retrieved articles for randomized controlled trials (RCTs), quasi-RCTs, and cluster trials. Selection criteria We included trials comparing single or bundled non-pharmacological interventions to no non-pharmacological treatment or different single or bundled non-pharmacological interventions. We assessed non-pharmacological interventions independently and in combination based on sufficient similarity in population, intervention, and comparison groups studied. We categorized non-pharmacological interventions as: modifying environmental stimulation, feeding practices, and support of the mother-infant dyad. We presented non-randomized studies identified in the search process narratively. Data collection and analysis We used standard methodological procedures expected by Cochrane. We used the GRADE approach to assess the certainty of evidence. Primary outcomes in infants at risk for, or having early symptoms consistent with, opioid withdrawal included length of hospitalization and pharmacological treatment with one or more doses of opioid or sedative medication. Primary outcomes in infants receiving opioid treatment for symptoms consistent with opioid withdrawal included length of hospitalization, length of pharmacological treatment with opioid or sedative medication, and maximum and cumulative doses of opioid medication. Main results We identified six RCTs (353 infants) in which infants at risk for, or having symptoms consistent with, opioid withdrawal participated between 1975 and 2018. We identified no RCTs in which infants receiving opioid treatment for symptoms consistent with opioid withdrawal participated. The certainty of evidence for all outcomes was very low to low. We also identified and excluded 34 non-randomized studies published between 2005 and 2018, including 29 in which infants at risk for, or having symptoms consistent with, opioid withdrawal participated and five in which infants receiving opioid treatment for symptoms consistent with opioid withdrawal participated. We identified seven preregistered interventional clinical trials that may qualify for inclusion at review update when complete. Of the six RCTs, four studies assessed modifying environmental stimulation in the form of a mechanical rocking bed, prone positioning, non-oscillating waterbed, or a low-stimulation nursery; one study assessed feeding practices (comparing 24 kcal/oz to 20 kcal/oz formula); and one study assessed support of the maternal-infant dyad (tailored breastfeeding support). There was no evidence of a difference in length of hospitalization in the one study that assessed modifying environmental stimulation (mean difference [MD) -1 day, 95% confidence interval [CI) -2.82 to 0.82; 30 infants; very low-certainty evidence) and the one study of support of the maternal-infant dyad (MD -8.9 days, 95% CI -19.84 to 2.04; 14 infants; very low-certainty evidence). No studies of feeding practices evaluated the length of hospitalization. There was no evidence of a difference in use of pharmacological treatment in three studies of modifying environmental stimulation (typical risk ratio [RR) 1.00, 95% CI 0.86 to 1.16; 92 infants; low-certainty evidence), one study of feeding practices (RR 0.92, 95% CI 0.63 to 1.33; 49 infants; very low-certainty evidence), and one study of support of the maternal-infant dyad (RR 0.50, 95% CI 0.13 to 1.90; 14 infants; very low-certainty evidence). Reported secondary outcomes included neonatal intensive care unit (NICU) admission, days to regain birth weight, and weight nadir. One study of support of the maternal-infant dyad reported NICU admission (RR 0.50, 95% CI 0.13 to 1.90; 14 infants; very low-certainty evidence). One study of feeding practices reported days to regain birth weight (MD 1.10 days, 95% CI 2.76 to 0.56; 46 infants; very low-certainty evidence). One study that assessed modifying environmental stimulation reported weight nadir (MD -0.28, 95% CI -1.15 to 0.59; 194 infants; very low-certainty evidence) and one study of feeding practices reported weight nadir (MD -0.8, 95% CI -2.24 to 0.64; 46 infants; very low-certainty evidence). Authors' conclusions We are uncertain whether non-pharmacological care for opioid withdrawal in newborns affects important clinical outcomes including length of hospitalization and use of pharmacological treatment based on the six included studies. The outcomes identified for this review were of very low- to low-certainty evidence. Combined analysis was limited by heterogeneity in study design and intervention definitions as well as the number of studies. Many prespecified outcomes were not reported. Although caregivers are encouraged by experts to optimize non-pharmacological care for opioid withdrawal in newborns prior to initiating pharmacological care, we do not have sufficient evidence to inform specific clinical practices. Larger well-designed studies are needed to determine the effect of non-pharmacological care for opioid withdrawal in newborns.

Published
2018
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40. A Collaborative Multicenter QI Initiative to Improve Antibiotic Stewardship in Newborns

Author

Dukhovny, Dmitry, primary, Buus-Frank, Madge E., additional, Edwards, Erika M., additional, Ho, Timmy, additional, Morrow, Kate A., additional, Srinivasan, Arjun, additional, Pollock, Daniel A., additional, Zupancic, John A.F., additional, Pursley, DeWayne M., additional, Goldmann, Donald, additional, Puopolo, Karen M., additional, Soll, Roger F., additional, and Horbar, Jeffrey D., additional

Published
2019
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41. Using NHSN’s Antimicrobial Use Option to Monitor and Improve Antibiotic Stewardship in Neonates

Author

O’Leary, Erin N., primary, van Santen, Katharina L., additional, Edwards, Erika M., additional, Braun, David, additional, Buus-Frank, Madge E., additional, Edwards, Jonathan R., additional, Guzman-Cottrill, Judith A., additional, Horbar, Jeffrey D., additional, Lee, Grace M., additional, Neuhauser, Melinda M., additional, Roberts, Jessica, additional, Schulman, Joseph, additional, Septimus, Edward, additional, Soll, Roger F., additional, Srinivasan, Arjun, additional, Webb, Amy K., additional, and Pollock, Daniel A., additional

Published
2019
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42. Family Involvement in Quality Improvement: From Bedside Advocate to System Advisor

Author

Joanna F, Celenza, Denise, Zayack, Madge E, Buus-Frank, and Jeffrey D, Horbar

Subjects
Parents, Intensive Care Units, Neonatal, Decision Making, Infant, Newborn, Intensive Care, Neonatal, Humans, Family, Patient Participation, Quality Improvement
Abstract

Family involvement in newborn intensive care quality improvement dates back to the 1980s. In recent years, there has been an evolution of support for family partnerships at the bedside, transforming parents from being passively present to being active and engaged caregivers and team members. Through those same efforts, a transformational understanding of the power of the family perspective in system design and improvement has occurred. Even with the progression and deepening of this involvement, opportunities exist to learn from families and to improve the quality of neonatal care as a result of the unique family perspective.

Published
2017

43. Who Should Teach the Gifted.

Author

Shelby, Madge E.

Abstract

The author supports the assumption that the role of the teacher of gifted children differs in some substantive way from the role of the teacher in general. Specific teacher traits, knowledges, techniques, methods, and materials which are unique to effective teaching of the gifted are explored. (Author/SBH)

Published
1978

44. Implications for Math Learning and the Disadvantaged Child.

Author

Shelby, Madge E.

Abstract

Presented is a collection of very brief chapters (or sections) drawn from a variety of sources which discuss the characteristics of the disadvantaged learner. In addition, suggestions for teaching mathematics to the disadvantaged using a laboratory approach are made. Conclusions include a description of the attributes necessary to be an effective teacher of the disadvantaged. Also included is a short description of a teacher training program, a preschool education program, and a support program being used in the Appalachian region. (MK)

Published
1980

45. Investigation of Role Influence in Child Study Teams.

Author

Shelby, Madge E.

Abstract

A review of the literature and a detailed analysis of five specific studies on placement team functioning is presented. Among findings are a strong positive relation between staff role and participation (school psychologists were ranked highest on both variables while regular education teachers were ranked lowest) and a very powerful set of role expectations calling for more participation from school psychologists and special education teachers and less from regular education teachers and parents. Future implications for school psychologists are noted, including training in underlying theories of teams, the nature of decisionmaking processes, and the reaction of team members to the team experience. The importance of adding to the empirical study of teams is stressed. (CL)

Published
1985

46. A School-Based Therapeutic/Educational Program for Severely Disturbed Latency Aged Children.

Author

Shelby, Madge E.

Abstract

Through joint efforts of mental health and education professionals, a school-based therapeutic/educational program for seriously emotionally disturbed children, some of whom had additional identified disabilities such as mental retardation, was initiated with 15 students (ages 8-13). The educational component of the program was based on an individualized education program (IEP) for each student, while the therapeutic component consisted primarily of group therapy treatment focusing on social skills, insight groups, and expressive activities. A parent advocacy group was formed, and community awareness activities planned and executed. Posttest evaluations following 6 months of program operation indicated that 12 of the 15 students met the target academic goal of increasing their academic achievement levels by 6 months. Improvement in levels of behavioral functioning based on identified social/emotional objectives showed similar improvement for 12 of the 15 students. Among conclusions drawn from the initial program effort were (1) that the primary population for a latency aged program of this type is single-diagnosed seriously emotionally disturbed students rather than those with multiple disabilities, and (2) that better definition of the role of the mental health worker in the classroom was needed. (JW)

Published
1988

47. Promoting Positive Attitudes between Mainstreamed SEM Students and Regular Students in an Elementary School Setting.

Author

Shelby, Madge E.

Abstract

Because handicapped and nonhandicapped students in a Pennsylvania elementary school were not sucessfully mainstreamed and lacked social skills, a practicum was devised to (1) teach social behavior skills to socially/emotionally maladjusted (SEM) students, and (2) present social skill intervention strategies promoting a positive attitude between SEM students and nonhandicapped peers. Participating were two teachers each in grades three, four, five, and six; nine SEM students; and 134 homogeneously grouped students in regular classrooms. Intervention consisted of presentations of films, provision of reading materials for teachers and students, presentation of awareness activities to students by regular classroom teachers, and presentation of a videotaped four-part skill training program designed to develop students' feelings of self-confidence and positive self-image. Evaluations were made on the basis of behavioral observations and sociometric and teacher rating scales. Standards of performance were met for all objectives. Comparison of pre- and post- intervention ratings revealed a significant increase in positive attitudes of the nine SEM students and the 134 regular students. Also, considerable gains were made in teacher attitude toward students experiencing difficulty with social interaction. (Sample program materials and data collection instruments are appended.) (Author/RH)

Published
1986

49. Adherence of Newborn-Specific Antibiotic Stewardship Programs to CDC Recommendations

Author

Ho, Timmy, primary, Buus-Frank, Madge E., additional, Edwards, Erika M., additional, Morrow, Kate A., additional, Ferrelli, Karla, additional, Srinivasan, Arjun, additional, Pollock, Daniel A., additional, Dukhovny, Dmitry, additional, Zupancic, John A.F., additional, Pursley, DeWayne M., additional, Soll, Roger F., additional, and Horbar, Jeffrey D., additional

Published
2018
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