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Objective: Structural changes are a major cause of pharmaco-resistant focal epilepsy. Surgical therapeutic options are based on the identification of the epileptogenic focus and its structural connectivity. The intention of our study was to analyze structural epileptic connectivity and to approach a[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Background Hemodynamic alterations of extracranial veins are considered an etiologic factor in multiple sclerosis (MS). However, ultrasound and MRI studies could not confirm a pathophysiological link. Because of technical challenges using standard diagnostics, information about the involvement of superficial intracranial veins in proximity to the affected brain in MS is scarce. Purpose To comprehensively investigate the hemodynamics of intracranial veins and of the venous outflow tract in MS patients and controls. Study Type Prospective. Population Twenty‐eight patients with relapsing‐remitting MS (EDSS1.9 ± 1.1; range 0-3) and 41 healthy controls. Field Strength/Sequence 3T/2D phase‐contrast and time‐resolved 4D flow MRI, extra‐ and transcranial sonography. Assessment Hemodynamics within the superficial and deep intracranial venous system and outflow tract including the internal, basal, and great cerebral vein, straight, superior sagittal, and transverse sinuses, internal jugular and vertebral veins. Sonography adhered to the chronic cerebrospinal venous insufficiency (CCSVI) criteria. Statistical Tests Multivariate repeated measure analysis of variance, Student's two‐sample t‐test, chi‐square, Fisher's exact test; separate analysis of the entire cohort and 32 age‐ and sex‐matched participants. Results Multi‐ and univariate main effects of the factor group (MS patient vs. control) and its interactions with the factor vessel position (lower flow within dorsal superior sagittal sinus in MS, 3 ± 1 ml/s vs. 3.8 ± 1 ml/s; P < 0.05) in the uncontrolled cohort were attributable to age‐related differences. Age‐ and sex‐matched pairs showed a different velocity gradient in a single segment within the deep cerebral veins (great cerebral vein, vena cerebri magna [VCM] 7.6 ± 1.7 cm/s; straight sinus [StS] 10.5 ± 2.2 cm/s vs. volunteers: VCM 9.2 ± 2.3 cm/s; StS 10.2 ± 2.3 cm/s; P = 0.01), reaching comparable velocities instantaneously downstream. Sonography was not statistically different between groups. Data Conclusion Consistent with previous studies focusing on extracranial hemodynamics, our comprehensive analysis of intracerebral venous blood flow did not reveal relevant differences between MS patients and controls.

Objective: Tumourigenesis is driven by the reprogramming of cellular metabolism, which derives directly or indirectly from genetic or epigenetic alterations. The purpose of this study was to analyze the global metabolic/transcriptomic profile of glioblastoma (in-vivo 21 patients and ex-vivo 33 [for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Objective: The biology of recurrent glioblastoma is a dynamic process influenced by selection pressure induced by different antitumoral therapies. The characteristics of these biological processes have been rarely explored, which complicates treatment. Checkpoint-inhibition (PD1/PD-L1 Inhibition)[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)