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OBJECTIVES: The consumption of non-nutritive sweeteners (NNS) through foods and beverages have increased worldwide. The effects of NNS consumption on body weight, glycemic control, or type 2 diabetes incidence are not well understood. While studies in animal models suggest potentially harmful effects of NNS on metabolic health, randomized controlled trials in humans suggest moderate benefits of NNS use on body weight. The relationship between artificial sweeteners and metabolic disease may be linked to their purported effects on sweet taste preference. The Evidence Analysis Library of the Academy of Nutrition and Dietetics has given a grade of V, concluding that adequately powered studies have not been conducted to evaluate effect of aspartame on preference for sweet taste. Thus, the goal of this study was to test the effect of aspartame, an artificial non-saccharide sweetener, on sweet taste preference in college-aged students. We hypothesized that a short-term increased intake of aspartame will increase sweet-taste preference. METHODS: Sixteen college-aged students, between the ages of 18 and 24 were recruited from Samford University, and randomized into 2 experimental groups and a control group. The experimental groups received either a nomal-dose of 543 mg aspartame (EQUAL) or a high-dose of 2172 mg aspartame, which was the equivalent to drinking 3 or 12, 12-oz cans of aspartame-containing beverage, respectively. The control group received 200 mg blue food-coloring, which was also added to experimental groups. The intervention period was for 7 days. Body weight, height, 24-hour food recall (ASA-24), and the Monell two-series forced-choice test for sweet preference testing were completed, both before and after the intervention period. RESULTS: Our studies showed a significant increase in sweet taste preference for the higher dose aspartame group. This was not associated with an increase in total or added sugars, total fat intake, or change in body weight. CONCLUSIONS: These findings raise the possibility that a short-term increased intake of aspartame may influence sweet taste preference in college-aged students. FUNDING SOURCES: None.