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OBJECTIVE: To characterize clinically and epidemiologically a female population diagnosed with acne. MATERIALS AND METHODS: A retrospective observational study was performed at a dermatological center in Bogota, Colombia, from June to October 2021. We evaluated female patients with a diagnosis of acne. The clinical history and demographic factors were evaluated. The Global Acne Grading System (GAGS) tool and the Dermatology Life Quality Index (DLQI) were applied. The χ2 test of independence was applied. RESULTS: A total of 251 patients were analyzed. The median age was 21 years, the predominant level of severity was mild, and most patients had mild impairment in quality of life. The areas with the greatest involvement were forehead, nose, cheeks and submandibular region. Forty-three percent of the patients with a gynecologic history reported having an irregular menstrual cycle and 7.5% had a confirmed diagnosis of polycystic ovary syndrome. Four out of 5 patients had a history of acne during adolescence. The main triggering factors were stress and menstruation. There was a significant association between the GAGS classification, DLQI, the use of a face mask, as well as polycystic ovary syndrome and stress. CONCLUSIONS: Acne in women is an entity that should be evaluated and treated from a different perspective taking into account the pathophysiological influence of endocrine and gynecological components. [ABSTRACT FROM AUTHOR]