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35 results on '"Maddy, Krisna"'

3. Impact of Preoperative Intervertebral Disc Degeneration on Patient-Reported Outcome Measures After Lumbar Fusion

Author

Tarawneh, Omar H., Narayanan, Rajkishen, Trenchfield, Delano, Lee, Yunsoo, Issa, Tariq Z., Dulitzki, Yoni, Pashaee, Bahram, Maddy, Krisna, Bash, Hannah, Karthikeyan, Gokul, Kaye, lan David, Mangan, John J., Canseco, Jose A., Hilibrand, Alan S., Vaccaro, Alexander R., Kepler, Christopher K., Schroeder, Gregory D., and Lee, Joseph K.

Published
2024
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10. Bon Sante(Good Health): Factors Influencing PrEP Use Among Haitians/Haitian Americans

Author

Sternberg, Candice A., Daniel, E. Valerie, Marcelin, Dora, Chery, Maurice Junior, Maddy, Krisna, Richard, Danelle, Thomas, Tanya, Ravix, Jovanka, Warner, Joshua, Titus, Micaelle, Francois, Aline, Borick, Joseph, Feaster, Daniel J., Doblecki-Lewis, Susanne, Jones, Deborah L., Alcaide, Maria L., and Dale, Sannisha K.

Abstract

Background: The HIV/AIDS epidemic has disproportionately affected Black individuals in the USA, and this health disparity has increased over time. Despite the effectiveness of pre-exposure prophylaxis (PrEP) as a prevention tool for HIV, there are disparities in its use, and uptake of this intervention remains low among racial and ethnic minorities, including Haitians/Haitian Americans. In this study, factors influencing PrEP use among Haitians/Haitian Americans in Miami, FL, are explored to provide necessary data to address disparities. Methods: The research team collaborated with local organizations to recruit 30 individuals (Haitians/Haitian Americans) between February 4 and October 1, 2021, and conducted semi-structured interviews. All interviews were audio-recorded and transcribed, and NVivo® was used to analyze the transcripts for emergent themes. Results: The study sample comprised 30 adults of Haitian descent in Miami, FL (50% female, approximately 67% with a high school education or more, mean age = 43.7 ± 13 years, and 74.2% born in Haiti). Four primary themes emerged from the analysis: (1) limited PrEP awareness, (2) underutilization of PrEP, (3) inadequate discussion of HIV prevention strategies, and (4) PrEP delivery encompassing barriers and facilitators for PrEP delivery and promotion strategies. Conclusion: This study indicated that there is a critical need to increase Haitians/Haitian Americans’ knowledge regarding PrEP. Health communication interventions tailored specifically for Haitians/Haitian Americans that target stigma, attitudes toward HIV, and risk perception may be significant in increasing PrEP in this population.

Published
2024
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17. Viv Byen (Live Well): A Qualitative Pilot Study to Assess Telehealth Use for HIV Care Among People of Haitian Descent

Author

Sternberg, Candice A., primary, Jackyvens, Camille, additional, Jean, Raema Mimrod, additional, Chery, Maurice Junior, additional, Batalien, Blonsky, additional, Maddy, Krisna, additional, Richard, Danelle, additional, Duthely, Lunthita M., additional, Botero, Valeria, additional, Rodriguez, Allan, additional, Boulanger, Catherine, additional, Blanc, Judite, additional, Bartholomew, Tyler S., additional, Tookes, Hansel E., additional, Dale, Sannisha K., additional, and Alcaide, Maria L., additional

Published
2023
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28. Transgenic APOEε4/4 overexpression induces reactivity in astrocytes with a European APOEε4/4 local ancestry, but not in astrocytes with an African APOEε4/4 local ancestry

Author

Oron, Oded, primary, Rodgers, Joey P, additional, Vasquez, Marina Lipkin, additional, Celis, Katrina, additional, Maddy, Krisna S., additional, Chambers, Christopher M, additional, Feliciano‐Astacio, Briseida E., additional, Beecham, Gary W., additional, Cuccaro, Michael L., additional, Cukier, Holly N., additional, Blurton‐Jones, Mathew, additional, Pericak‐Vance, Margaret A., additional, Vance, Jeffery M., additional, and Dykxhoorn, Derek M., additional

Published
2021
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30. African and European local ancestry surrounding Apolipoprotein E has a differential biological effect upon acute amyloid beta exposure in iPSC‐differentiated astrocytes

Author

Oron, Oded, primary, Maddy, Krisna S., additional, Celis, Katrina, additional, Cukier, Holly N., additional, Pericak‐Vance, Margaret A., additional, Young, Juan, additional, Blurton‐Jones, Mathew, additional, Griswold, Anthony J., additional, Vance, Jeffery M., additional, and Dykxhoorn, Derek M., additional

Published
2020
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32. P3-206: INVESTIGATING ANCESTRY SPECIFIC DIFFERENCES IN APOE FUNCTION USING INDUCED PLURIPOTENT STEM CELLS

Author

Dykxhoorn, Derek M., primary, Cukier, Holly N., additional, Maddy, Krisna S., additional, Adams, Larry D., additional, Starks, Takiyah D., additional, Celis, Katrina, additional, Acosta, Heriberto, additional, Feliciano-Astacio, Briseida E., additional, Byrd, Goldie S., additional, Cuccaro, Michael L., additional, Beecham, Gary W., additional, Pericak-Vance, Margaret A., additional, and Vance, Jeffery M., additional

Published
2019
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34. Algorithm for evaluating ophthalmic artery pseudo-occlusion during intra-arterial chemotherapy for retinoblastoma

Author

Maddy, Krisna, Luther, Evan, Walker, Ariel, Hackett, Ashia, Lu, Victor, and Starke, Robert

Abstract

Background and importance Intra-arterial chemotherapy infusion for retinoblastoma is typically performed via selective catheterization of the ophthalmic artery. Anastomoses between the external carotid and the ophthalmic arteries have also been utilized when the ophthalmic artery cannot be catheterized directly. However, these are not present in every patient.Clinical presentation A 10-month-old boy presented with bilateral retinoblastoma and underwent one round of intra-arterial chemotherapy (IAC) via direct catheterization of the ophthalmic arteries. Combined with adjuvant laser therapy, they experienced symptomatic improvement and tumour regression. However, during subsequent treatment sessions both ophthalmic arteries did not have anterograde flow and attempts to catheterize their origin were unsuccessful. Unfortunately, no targetable anastomoses between the external carotid and ophthalmic arteries were identified for drug delivery. Due to the patient's anatomy, balloon occlusion of the ECA was felt to be unsafe. As a salvage technique, a balloon was inflated in the left internal carotid artery (ICA) distal to the ophthalmic take-off to redirect flow into the ophthalmic. Repeat angiography with the distal ICA occluded showed improved flow into the ipsilateral ophthalmic artery. IAC was then successfully delivered through the left ICA.Conclusion This case illustrates the importance of utilizing creative endovascular techniques for targeted intra-arterial drug delivery when other conventional measures fail as these patients often have limited, and potentially higher risk, therapeutic alternatives.

Published
2024
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35. A Comparison of Clinical Outcomes Between Anterior Cervical Discectomy and Fusion Versus Posterior Cervical Laminoplasty for Multilevel Cervical Myelopathy.

Author

Lee Y, Trenchfield D, Berthiaume E, Tomlak A, Narayanan R, Brush P, Heard J, Maddy K, Issa T, Lambrechts M, Kaye ID, Mangan J, Grasso G, Canseco J, Vaccaro A, Kepler C, Schroeder G, and Hilibrand A

Abstract

Study Design: Retrospective Cohort., Objective: To compare patient-reported outcomes and surgical outcomes after anterior cervical discectomy and fusion (ACDF) versus cervical laminoplasty for multilevel cervical spondylotic myelopathy., Background: Treatment options for multilevel cervical spondylotic myelopathy include ACDF and cervical laminoplasty. Given that the literature has been mixed regarding the optimal approach, especially in patients without kyphosis, there is a need for additional studies investigating outcomes between ACDF and cervical laminoplasty., Methods: A retrospective review was conducted of adult patients undergoing 3 or 4-level surgery. Patients with preoperative kyphosis based on C2-C7 Cobb angles were excluded. The electronic medical record and institutional databases were reviewed for baseline characteristics, surgical outcomes, and patient-reported outcomes., Results: A total of 101 patients who underwent ACDF and 52 patients who underwent laminoplasty were included in the study. The laminoplasty cohort had a higher overall Charlson Comorbidity Index (3.10 ± 1.43 vs 2.39 ± 1.57, P = 0.011). Both groups had a comparable number of levels decompressed, C2-C7 lordosis, and diagnosis of myelopathy versus myeloradiculopathy. Patients who underwent laminoplasty had a longer length of stay (2.04 ± 1.15 vs 1.48 ± 0.70, P = 0.003) but readmission, complication, and revision rates were similar. Both groups had similar improvement in myelopathy scores (∆modified Japanese Orthopedic Association: 1.11 ± 3.09 vs 1.06 ± 3.37, P = 0.639). ACDF had greater improvement in Neck Disability Index (∆Neck Disability Index: -11.66 ± 19.2 vs -1.13 ± 11.2, P < 0.001), neck pain (∆Visual Analog Scale-neck: -2.69 ± 2.78 vs -0.83 ± 2.55, P = 0.003), and arm pain (∆Visual Analog Scale-arm: -2.47 ± 3.15 vs -0.48 ± 3.19, P = 0.010). These findings persisted in multivariate analysis except for Neck Disability Index., Conclusion: ACDF and cervical laminoplasty appear equally efficacious at halting myelopathic progression. However, patients who underwent ACDF had greater improvements in arm pain at 1 year postoperatively. Longitudinal studies evaluating the efficacy of laminoplasty to mitigate adjacent segment disease are indicated to establish a robust risk-benefit assessment for these 2 procedures., Level of Evidence: III., Competing Interests: Schroeder has received funds to travel from AO Spine and Medtronic. Dr Vaccaro has consulted or has done independent contracting for DePuy, Medtronic, Stryker Spine, Globus, Stout Medical, Gerson Lehrman Group, Guidepoint Global, Medacorp, Innovative Surgical Design, Orthobullets, Ellipse, and Vertex. He has also served on the scientific advisory board/board of directors/committees for Flagship Surgical, AO Spine, Innovative Surgical Design, and Association of Collaborative Spine Research. Dr Vaccaro has received royalty payments from Medtronic, Stryker Spine, Globus, Aesculap, Thieme, Jaypee, Elsevier, and Taylor Francis/Hodder and Stoughton. He has stock/stock option ownership interests in Replication Medica, Globus, Paradigm Spine, Stout Medical, Progressive Spinal Technologies, Advanced Spinal Intellectual Properties, Spine Medica, Computational Biodynamics, Spinology, In Vivo, Flagship Surgical, Cytonics, Bonovo Orthopaedics, Electrocore, Gamma Spine, Location Based Intelligence, FlowPharma, R.S.I., Rothman Institute and Related Properties, Innovative Surgical Design, and Avaz Surgical. He has also served as deputy editor/editor of Spine. In addition, Dr Vaccaro has also provided expert testimony. He has also served as deputy editor/editor of Clinical Spine Surgery. The remaining authors declare no conflict of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2024
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