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1. Preventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma: The PROACT Clinical Trial

Author

Austin, David, Maier, Rebecca H., Akhter, Nasima, Sayari, Mohammad, Ogundimu, Emmanuel, Maddox, Jamie M., Vahabi, Sharareh, Humphreys, Alison C., Graham, Janine, Oxenham, Helen, Haney, Sophie, Cresti, Nicola, Verrill, Mark, Osborne, Wendy, Wright, Kathryn L., Goranova, Rebecca, Bailey, James R., Kalakonda, Nagesh, Macheta, Mac, Kilner, Mari F., Young, Moya E., Morley, Nick J., Neelakantan, Pratap, Gilbert, Georgia, Thomas, Byju K., Graham, Richard J., Fujisawa, Takeshi, Mills, Nicholas L., Hildreth, Victoria, Prichard, Jonathan, Kasim, Adetayo S., Hancock, Helen C., and Plummer, Chris

Published
2024
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2. Ibrutinib as first-line therapy for mantle cell lymphoma: a multicenter, real-world UK study

Author

Tivey, Ann, Shotton, Rohan, Eyre, Toby A., Lewis, David, Stanton, Louise, Allchin, Rebecca, Walter, Harriet, Miall, Fiona, Zhao, Rui, Santarsieri, Anna, McCulloch, Rory, Bishton, Mark, Beech, Amy, Willimott, Victoria, Fowler, Nicole, Bedford, Claudia, Goddard, Jack, Protheroe, Sam, Everden, Angharad, Tucker, David, Wright, Josh, Dukka, Vasavi, Reeve, Miriam, Paneesha, Shankara, Prahladan, Mahesh, Hodson, Andrew, Qureshi, Iman, Koppana, Manasvi, Owen, Mary, Ediriwickrema, Kushani, Marr, Helen, Wilson, Jamie, Lambert, Jonathan, Wrench, David, Burney, Claire, Knott, Chloe, Talbot, Georgina, Gibb, Adam, Lord, Angela, Jackson, Barry, Stern, Simon, Sutton, Taylor, Webb, Amy, Wilson, Marketa, Thomas, Nicky, Norman, Jane, Davies, Elizabeth, Lowry, Lisa, Maddox, Jamie, Phillips, Neil, Crosbie, Nicola, Flont, Marcin, Nga, Emma, Virchis, Andres, Camacho, Raisa Guerrero, Swe, Wunna, Pillai, Arvind, Rees, Clare, Bailey, James, Jones, Steve, Smith, Susan, Sharpley, Faye, Hildyard, Catherine, Mohamedbhai, Sajir, Nicholson, Toby, Moule, Simon, Chaturvedi, Anshuman, and Linton, Kim

Published
2024
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3. Diagnostic uncertainty presented barriers to the timely management of acute thrombotic thrombocytopenic purpura in the United Kingdom between 2014 and 2019

Author

Bull, Tom P., McCulloch, Rory, Nicolson, Phillip L.R., Doyle, Andrew J., Shaw, Rebecca J., Langridge, Alexander, Sayar, Zara, Tucker, David L., Pettit, Michala, Perry, Rita, Thomas, William, Page, Catherine, Whalley, Ioana, Dutt, Tina, Garth, Louise, Lester, Will, Buka, Richard J., Subhan, Mary, Ware, Victoria, Rayment, Rachel, Castle, Daniel, Etherington, Astrid, Carter‐Brzezinski, Luke, Peters, Jayne, Corrigan, Claire, Sharma, Narind, Benson, Gary, Challenor, Sarah, Skinner, Thomas S., Zhao, Rui, McLeod‐Kennedy, Lyndsay A.G., Douglas, Kenneth, Knott, Amy, Smith, Sophie, Wolf, Julia, Todd, Sophie A., McDonald, Vickie, Rampotas, Alexandros, Dean, Christopher, Sangha, Gavinda, Pavord, Sue, Denny, Nicholas, Jaafar, Sarah, McLaughlin, David P.T., Ross, Jennifer E., Karanth, Mamatha, Beverstock, Sarah L., Mansonso, Lynn, Burrows, Samuel H., Tauro, Sudhir, Shenouda, Amir, Bailiff, Benjamin M., Kajita, Daniel, Hermans, Joannes, Goradia, Harshita, Finan, Emily M., Alford, Sarah, Pickard, Keir, Greystoke, Brigit, Fail, Thomas, Abdussalam, Asmaa, Roberts, Lara N, Clark, James B., Heeney, Natalie, Young, Jennifer, Maddox, Jamie, Srinath, Swathy, Khawaja, Jahanzeb, Parkes, Jayne, Babiker, Samah, Hunt, Beverley J., Wheeldon, Sarah L., Kerr, Paul, Tahhan, Molham, Vickers, Mark, Pike, Alexandra C., Hill, Quentin, Mustafa, Nadreen, Almaremi, Azza, Hughes, Emily, McGoldrick, Sean J.F., Loizou, Eleana, James, Izabela, Boyce, Sara R., Farmer, Isabel, Thanigaikumar, Murugaiyan, Wickenden, Katherine, Gooding, Richard, Thornton, Kathryn, Kane, Clare, Cole, Adam, Griffin, JessicaC, Docherty, Suzanne, Dixon, Kiri I., Crowe, Josephine, Sheridan, Mathew, De Lord, Corinne, Sud, Amit, Austin, Anna, Coooper, Nichola, Bailey, Chris, Attwell, Luke, Hall, Rachel, Gray, Benjamin, Chauhan, Salena R., Lokare, Anand, Gudger, Amy, Horgan, Claire, Venkatadasari, Indrani, Kaddam, Israa, Mapplebeck, Claire L., Van Veen, Joost, Raj, Maya, De Abrew, Kanchana, Belsham, Edward, Gyansah, Cecilia, Sadullah, Shalal, Salhan, Beena, Murrin, Richard, Williams, Rhys L., Stewart, Andrew, Cornish, Naomi, Otton, Sophie, Khan, Zeeshan, Ackroyd, Sam, Chen, Lucia Y., Lafferty, Nicholas P., Leonforte, Francesca, Pemberton, Nicholas, Rawi, Emanal, Triantafyllopoulou, Diana, Adiyodi, Jagdish, Yong, Jun, Jones, Elizabeth, Davies, David, Peck, Rachel C., Philip, Robson, Seddon, Thomas, Cahalin, Paul, Prodger, Catherine, Dutton, David A., Sternberg, Alexander J., Chengal, Rajani, Polzella, Paolo, and Scully, Marie

Published
2022
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4. CREST‐UK: Real‐world effectiveness, safety and outpatient delivery of CPX‐351 for first‐line treatment of newly diagnosed therapy‐related AML and AML with myelodysplasia‐related changes in the UK.

Author

Mehta, Priyanka, Campbell, Victoria, Maddox, Jamie, Floisand, Yngvar, Kalakonda, Anita J. M., O'Nions, Jenny, Coats, Thomas, Nagumantry, Sateesh, Hodgson, Katherine, Whitmill, Richard, Amott, Ian, Flynn, Gillian, Taussig, David, Zhao, Rui, Cunningham, Nicholas, Roset, Montse, Cuadras, Daniel, Medalla, Greg, Kuter, Hayley, and Park, Saemi

Subjects
CLINICAL trials, ACUTE myeloid leukemia, CELL transplantation, OVERALL survival, CONFIDENCE intervals
Abstract

Summary: Favourable outcomes with CPX‐351 versus conventional 7 + 3 were demonstrated in the pivotal phase III trial in adults aged 60–75 years with newly diagnosed, highrisk/secondary acute myeloid leukaemia (AML). As a complement to the clinical trial and to address important data gaps, the CPX‐351 Real‐World Effectiveness and SafeTy (CREST‐UK; NCT05169307) study evaluated the use of CPX‐351 in routine clinical practice in the UK, in 147 patients with newly diagnosed therapy‐related AML or AML with myelodysplasia‐related changes. Best response of complete remission or complete remission with incomplete platelet or neutrophil recovery was achieved by 53% of evaluable patients. Kaplan–Meier median overall survival (OS) was 12.8 months (95% confidence interval 9.2–15.3). Fifty (34%) patients proceeded to haematopoietic cell transplantation (HCT); median OS landmarked from the HCT date was not reached. There were no new safety concerns with CPX‐351 identified in CREST‐UK. Patients treated with CPX‐351 in the outpatient setting spent an average of 24.4, 16.7, 28.2, and 27.7 fewer days on the ward compared with inpatients during first induction, second induction, first consolidation, and second consolidation, respectively. The results from CREST‐UK provide valuable insights into the effectiveness, safety, and outpatient delivery of CPX‐351 in routine clinical practice in the UK. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Fludarabine, Cytarabine, Granulocyte Colony-Stimulating Factor, and Idarubicin With Gemtuzumab Ozogamicin Improves Event-Free Survival in Younger Patients With Newly Diagnosed AML and Overall Survival in Patients With NPM1 and FLT3 Mutations

Author

Russell, Nigel H., primary, Wilhelm-Benartzi, Charlotte, additional, Othman, Jad, additional, Dillon, Richard, additional, Knapper, Steven, additional, Batten, Leona M., additional, Canham, Joanna, additional, Hinson, Emily L., additional, Betteridge, Sophie, additional, Overgaard, Ulrik Malthe, additional, Gilkes, Amanda, additional, Potter, Nicola, additional, Mehta, Priyanka, additional, Kottaridis, Panagiotis, additional, Cavenagh, Jamie, additional, Hemmaway, Claire, additional, Arnold, Claire, additional, Freeman, Sylvie D., additional, Dennis, Mike, additional, Kallenbach, Maria, additional, Severinsen, Marianne, additional, Holm, Mette, additional, Maxwell Norgaard, Jan, additional, Beier Ommen, Hans, additional, Culligan, Dominic, additional, Tighe, Jane, additional, Craig, Jenny, additional, Crawley, Charles, additional, Krishnamurthy, Pramila, additional, Sadik, Walid, additional, Smith, Jeffery, additional, Dasgupta, Ranjit, additional, Berkhan, Leanne, additional, Bowett, Peter, additional, Doocey, Richard, additional, Emmett, Shannon, additional, Hawkins, Timothy, additional, Patton, Nigel, additional, Pemberton, Lucy, additional, Milne, Alison, additional, Roy, Ashok, additional, Simpson, Sylwia, additional, Cuthbert, Robert, additional, Finnegan, Damian, additional, Francis McMullin, Mary, additional, Pechey, Victoria, additional, Lovell, Richard, additional, Milligan, Donald, additional, Paneesha, Shankara, additional, Cahalin, Paul, additional, Kelsey, P., additional, Ackroyd, Sam, additional, Wiliams, Adrian, additional, Evely, Roger, additional, Marks, David, additional, Fletcher, Andrew, additional, Al-Ani, Maryam, additional, Ahmed, Khalil, additional, Lush, Richard, additional, Rye, Adam, additional, Cutting, Robert, additional, Welch, Emma, additional, Wodzinski, Mark, additional, Butler, Andrew, additional, Fernyhough, Liam, additional, Ganly, Peter, additional, Gibbons, Steve, additional, Smith, Mark, additional, Spearing, Ruth, additional, Peniket, Andy, additional, Hatcliffe, Faye, additional, Patel, Amit, additional, Lindsay, Kathrine, additional, Brearton, Gillian, additional, Tuegar, Salah, additional, Gandhi Anna Cowley, S., additional, Copplestone, Adrian, additional, Hunter, Hannah, additional, Medd, Patrick, additional, Nokes, Tim, additional, Rule, Simon, additional, Thomas, Wayne, additional, Joseph, Joe, additional, Kaul, Stuti, additional, Sorour, Youssef, additional, Chvuka, Shingi, additional, Mangos, Hilda, additional, Neylon, Annette, additional, Farrell, Katrina, additional, Edwards, Hugh, additional, Hanlon, Katharine, additional, Fail, Tom, additional, Goodrick, Margaret, additional, Heartin, Earnest, additional, Hoyle, Christine, additional, Carr, Robert, additional, Raj, Kavita, additional, Krogh Jensen, Morten, additional, Janmohamed, Riaz, additional, Kaczmarski, Richard, additional, Sugai, Taku, additional, Ademokun, Debo, additional, Chalmers, Isobel, additional, Hodson, Andrew, additional, Gomez, Cesar, additional, Sadullah, Shala, additional, Kwan, Mark, additional, Longmuir, Karyn, additional, Wilson-Morkeh, Isaac, additional, Hunter, Ann, additional, Martin, Murray, additional, Saravanamuttu, Kandeepan, additional, Sidra, Gamal, additional, Burns, Sarah, additional, Gibbs, Simon, additional, Tholouli, Eleni, additional, Aldouri, Maadh, additional, Andrews, Vivienne, additional, Eden, Ayed, additional, Dungarwalla, Moez, additional, White, Denise, additional, Laird, Jane, additional, Mitchell, Lindsey, additional, Murphy, John, additional, Paterson, Pamela, additional, Raafat, Alaeddin, additional, Mannari, Deepak, additional, Davies, Simon, additional, Austen, Belinda, additional, Allford, Sarah, additional, Kakalamudi, Sudhakar, additional, Basu, Supratik, additional, Hada, Sunil, additional, Jacob, Abraham, additional, MacWhonell, Alan, additional, McCaig, Alison, additional, Gelly, Keith, additional, Kerr, Ron, additional, Meiklejohn, David, additional, Tauro, Sudhir, additional, Lawes, Matthew, additional, Bowen, Angela, additional, Krishnamurthy, Suchitra, additional, Byrne, Jenny, additional, Dasgupta, Emma, additional, Russell, Nigel, additional, Stokley, Simone, additional, Friis, Lone, additional, Marcher, Claus, additional, Bake, Bart, additional, Chapple, Mary, additional, Moreton, Paul, additional, Omran, Asad, additional, Patil, Kavita, additional, Wright, David, additional, Jack, Fergus, additional, Maddams, Rebecca, additional, Corser, Robert, additional, Cranfield, Tanya, additional, Dignum, Helen, additional, Ganczakowski, Mary, additional, Jones, Christopher, additional, Craddock, Charles, additional, Moss, Paula, additional, Murray, Jim, additional, Craig, Joanne, additional, Forsyth, Peter, additional, Lush, Chris, additional, Wei Bjerrum, Ole, additional, Borregaard, Niels, additional, Kampmann, Peter, additional, Kjeldsen, Lars, additional, Juul Nielsen, Ove, additional, Niemann, Carsten, additional, Lykke Petersen, Soeren, additional, Udby Peter Møller, Lene, additional, Alfred, Arun, additional, Barker, Helen, additional, Went, Richard, additional, Groch, Henri, additional, Mucklow, Stuart, additional, Sampson, Rebecca, additional, Chacko, Joseph, additional, Hall, Rachel, additional, Walewska, Renata, additional, Creach, Desmond, additional, Pottinger, Bryson, additional, Addada, Juanah (Jo), additional, Hamilton, Malcolm, additional, Kerr, Paul, additional, Ngu, Loretta, additional, Rudin, Claudius, additional, Ruell, Jackie, additional, Dalley, Chris, additional, Kaur, Harpreet, additional, Reilly, John, additional, Snowden, John, additional, Ferguson, Paul, additional, Dyer, Peter, additional, Chandra, Deepak, additional, DeVos, Johannes, additional, Grey-Davies, Elisabeth, additional, Hendry, Louise, additional, Corbett, Timothy, additional, Crowe, Josephine, additional, Knechtli, Christopher, additional, Wexler, Sarah, additional, Fernandes, Savio, additional, Neilson, Jeff, additional, Houghton, John, additional, Jowitt, Simon, additional, Thomas-Dewing, Rowena, additional, Williams, Mark, additional, Zaman, Sonya, additional, Cullis, Jonathan, additional, Everington, Tamara, additional, Grand, Effie, additional, Hasan, Yasmin, additional, Murrin, Richard, additional, Wandoo, Farooq, additional, Ismail, Saad, additional, Mohite, Unmesh, additional, Sati, Hamdi, additional, Jenner, Matthew, additional, Orchard, Kim, additional, Richardson, Deborah, additional, McCloskey, Kayleigh, additional, Xu Chin, Kate, additional, Fenella Willis, Neoh, additional, Sud, Amit, additional, Gharib, Maged, additional, Nicholson, Toby, additional, Bowen, David, additional, Janes, Sarah, additional, Eagleton, Helen, additional, O'Hea, Anne-Marie, additional, Pattinson, Jonathan, additional, Hervey, Victoria, additional, Lyons, Simon, additional, Marshall, Scott, additional, Nicolle, Annette, additional, Vavyla, Maria, additional, Burgess, Jordan, additional, Somervaille, Tim, additional, Somerfield, Sven, additional, Mamat, Mohd, additional, Tomlins, Jo, additional, Salesh, Sana, additional, David, Marianna, additional, Maddox, Jamie, additional, Plews, Diane, additional, Dang, Ray, additional, Potter, Mike, additional, Ellis, Lauren, additional, Nicholson, Emma, additional, Keat, Sally, additional, Ahmed Alhassani, Thubeena M., additional, Anjum, Farahn, additional, Chatterjee, Poulami, additional, Stanchev, Atanas, additional, Peters, Jayne, additional, Lindsay-Holmes Srividhya, Sarah, additional, Chodhouri, Senthil S., additional, Eve, Heather, additional, Smith, Steve, additional, Roberts, Patrick, additional, Rymes, Nicholas, additional, Zhao New Oo, Rui, additional, Ardeshna, Kirit, additional, Blombery, Piers, additional, Khwaja, Asim, additional, Linch, David, additional, Popat, Rakesh, additional, Virchis, Andres, additional, Yong, Kwee, additional, McIntyre, Victoria, additional, Horne, Gillian, additional, Bokhari, Syed, additional, Borg, Anton, additional, Chapman, Oliver, additional, Harrison, Beth, additional, Jackson, Nicholas, additional, Jobanputra, Shailesh, additional, Narayanan, Mekkali, additional, Rose, Peter, additional, Oun, Hajer, additional, Powell, Matthew, additional, Gilles, Julie, additional, Laing, Alison, additional, Devanny, Ian, additional, Haskins, Lea, additional, Micallef-Eynaud, Paul, additional, Maclean, Peter, additional, Alvares, Caroline, additional, Kell, Jonathan, additional, Knapper, Steve, additional, Davidson, Kerri, additional, McLintock, Lorna, additional, Rogers, Stephen, additional, Williamson, Peter, additional, Corbett, Gillian, additional, Goodman, Hugh, additional, Islam, Shahid, additional, Pullon, Humphrey, additional, Johnson, Peter, additional, Roddie, P.H., additional, Maughan, Elizabeth, additional, Mills, Juliet, additional, Shafeek, Salim, additional, Narat, Santosh, additional, Aitchison, Robin, additional, Bond, Lee, additional, Munro, Laura, additional, and Edwards, David, additional

Published
2024
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6. Ibrutinib as first line therapy for mantle cell lymphoma: A multicentre, real-world UK study

Author

Tivey, Ann, primary, Shotton, Rohan, additional, Eyre, Toby A., additional, Lewis, David, additional, Stanton, Louise, additional, Allchin, Rebecca, additional, Walter, Harriet Sarah, additional, Miall, Fiona, additional, Zhao, Rui, additional, Santarsieri, Anna, additional, McCulloch, Rory, additional, Bishton, Mark, additional, Beech, Amy, additional, Willimott, Victoria Clare, additional, Fowler, Nicole, additional, Bedford, Claudia, additional, Goddard, Jack, additional, Protheroe, Samuel, additional, Everden, Angharad, additional, Tucker, David L, additional, Wright, Joshua, additional, Dukka, Srivasavi, additional, Thomson, Miriam, additional, Paneesha, Shankara, additional, Prahladan, Mahesh, additional, Hodson, Andrew, additional, Qureshi, Iman, additional, Koppana, Manasvi, additional, Owen, Mary, additional, Ediriwickrema, Kushani, additional, Marr, Helen, additional, Wilson, Jamie, additional, Lambert, Jonathan, additional, Wrench, David J, additional, Burney, Claire N, additional, Knott, Chloe, additional, Talbot, Georgina, additional, Gibb, Adam, additional, Lord, Angela, additional, Jackson, Barry, additional, Stern, Simon, additional, Sutton, Taylor, additional, Webb, Amy Caitlin, additional, Wilson, Marketa, additional, Thomas, Nicky, additional, Norman, Jane, additional, Davies, Elizabeth, additional, Lowry, Lisa, additional, Maddox, Jamie, additional, Phillips, Neil, additional, Crosbie, Nicola, additional, Flont, Marcin, additional, Nga, Emma LM, additional, Virchis, Andres, additional, Guerrero Camacho, Raisa, additional, Swe, Wunna, additional, Pillai, Arvind Radhakrishna, additional, Rees, Clare, additional, Bailey, James, additional, Jones, Steve Gareth, additional, Smith, Susan, additional, Sharpley, Faye, additional, Hildyard, Catherine, additional, Mohamedbhai, Sajir, additional, Nicholson, Toby, additional, Moule, Simon, additional, Chaturvedi, Anshuman, additional, and Linton, Kim, additional

Published
2023
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7. P486: REAL-WORLD EFFECTIVENESS AND SAFETY OF CPX-351 IN PATIENTS AGED <60 AND ≥60 YEARS WITH NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA: CREST-UK POST-HOC ANALYSIS

Author

Mehta, Priyanka, primary, Campbell, Victoria, additional, Maddox, Jamie, additional, Floisand, Yngvar, additional, O’nions, Jenny, additional, Cross, Joe, additional, Coats, Thomas, additional, Lynam, Mark, additional, Roset, Montse, additional, Medalla, Greg, additional, Park, Saemi, additional, Kuter, Hayley, additional, Legg, Alex, additional, and Khan, Anjum, additional

Published
2023
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9. Preventing cardiotoxicity in patients with breast cancer and lymphoma: protocol for a multicentre randomised controlled trial (PROACT)

Author

Maier, Rebecca H, primary, Plummer, Chris, additional, Kasim, Adetayo S, additional, Akhter, Nasima, additional, Ogundimu, Emmanuel, additional, Maddox, Jamie, additional, Graham, Janine, additional, Stewart, Michael, additional, Wardley, Andrew, additional, Haney, Sophie, additional, Vahabi, Sharareh, additional, Oxenham, Helen, additional, Humphreys, Alison, additional, Cresti, Nicola, additional, Verrill, Mark, additional, Graham, Richard, additional, Chang, Lisa, additional, Hancock, Helen C, additional, and Austin, David, additional

Published
2022
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10. CREST-UK: CPX-351 Real-World Effectiveness and Safety Study for the Treatment of Newly Diagnosed Therapy-Related AML and AML with Myelodysplasia-Related Changes in the UK

Author

Mehta, Priyanka, primary, Khan, Anjum, additional, Maddox, Jamie, additional, Floisand, Yngvar, additional, Whitmill, Richard, additional, Cuadras, Daniel, additional, Pedros, Montse, additional, Park, Saemi, additional, Medalla, Greg, additional, Legg, Alex, additional, and Campbell, Victoria Louise, additional

Published
2022
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11. Additional file 1 of Adherence to guidelines across different specialties to prevent infections in patients undergoing immunosuppressive therapies

Author

Chadwick, David R., Sayeed, Laila, Rose, Matthew, Budd, Emily, Mohammed, Mo, Harrison, Sarah, Jaskiran Azad, and Maddox, Jamie

Abstract

Additional file 1: Table 1. Consensus guideline for interventions or screening tests to prevent infections in patients undergoing immunosuppressive therapies, as part of audit.

Published
2020
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16. DECC (dexamethasone, etoposide, chlorambucil, lomustine) as an oral chemotherapy regimen in relapsed and refractory diffuse large B‐cell lymphoma.

Author

Maddox, Jamie M., Horan, Matthew, Tafesh, Laith, Shrubsole, Caroline, and Osborne, Wendy

Subjects
*DIFFUSE large B-cell lymphomas, *CHLORAMBUCIL, *CANCER chemotherapy, *LYMPHOMAS, *ETOPOSIDE, *HODGKIN'S disease
Abstract

Keywords: Non-Hodgkin lymphoma; chemotherapy; clinical haematology EN Non-Hodgkin lymphoma chemotherapy clinical haematology e92 e94 3 02/02/21 20210201 NES 210201 The chemotherapy regimen PECC (prednisolone 40 mg days 1-7, etoposide 200 mg/m SP 2 sp days 1-3, chlorambucil 20 mg/m SP 2 sp days 1-4, CCNU [lomustine] 100 mg/m SP 2 sp day 1) was originally assessed in the 1980s in 15 patients with relapsed or refractory Hodgkin lymphoma.1 An overall response rate of 86% was reported (53% complete response [CR]) in this small patient group and the all-oral regimen became a popular palliative chemotherapy for Hodgkin lymphoma, at least in the North East of England from where the initial publication originated. In conclusion, DECC chemotherapy is an effective palliative regimen for patients with DLBCL, with a small number of patients achieving durable remissions without additional treatment. The role of an all-oral chemotherapy containing lomustine (CCNU) in advanced, progressive Hodgkin lymphoma: a patient-friendly palliative option which can result in longterm disease control. [Extracted from the article]

Published
2021
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18. Pneumococcal bacteraemia: clinical and microbiological epidemiology in Dundee, Scotland.

Author

Maddox JM and Winter JH

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Drug Resistance, Microbial, Female, Humans, Incidence, Infant, Male, Microbial Sensitivity Tests, Middle Aged, Penicillin Resistance, Retrospective Studies, Scotland epidemiology, Urban Population, Bacteremia epidemiology, Pneumococcal Infections epidemiology, Streptococcus pneumoniae
Abstract

Objective: To report the incidence of drug resistant Streptococcus pneumoniae isolated from blood culture in Dundee, Scotland. We shall also review the clinical and laboratory findings in these cases., Methods: A retrospective review was undertaken of all cases of S. pneumoniae bacteraemia identified in our local area during a three year period from August 1st, 1997 to July 31st, 2000 (107 cases.) Data was obtained from patient medical records, blood culture reports and results of Stoke's disk testing. Many organisms were also sent to the Scottish Meningococcus and Pneumococcus Reference Laboratory for serogrouping and determination of the minimum inhibitory concentration of common antibiotics., Results: Annual incidence of bacteraemia was approximately 15.9-17.8 per 100000 population. Mortality was 33% (34 and 30% for those with pneumonia or meningitis, respectively). No relationship was seen between patient age and overall mortality. Factors relating to increased mortality were a high respiratory rate (p=0.01), high blood urea level (p=0.05) and the presence of confusion (p<0.01) on admission to hospital. The incidence of penicillin resistant S. pneumoniae was 7%, all of these isolates having low level resistance. Macrolide resistance was 8%. Neither were found to be increasing over the three year period. The most common serogroups were 23 (18%) and 14 (12%)., Conclusions: The incidence of penicillin resistant S. pneumoniae isolated from blood culture in Dundee, Scotland, is similar to the UK average and did not appear to be rising between 1997 and 2000.

Published
2003
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