160 results on '"Maddalena Illario"'
Search Results
2. Gastrointestinal bezoars: Review of the literature and report of a rare case of pumpkin seed rectal impaction
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Maurizio Gentile, Maddalena Illario, Vincenzo De Luca, Giovanni Cestaro, Nunzio Velotti, Stefania Sivero, and Mario Musella
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Gastrointestinal ,Bezoar ,Pumpkin seeds ,Rectal burning ,Psychiatric illness ,Surgery ,RD1-811 - Abstract
In science, bezoar is a mass of hair or undigested vegetable matter, found in a human or animal's intestines, similar to a hairball. Usually, it is found trapped in every part of the gastrointestinal system and must be distinguished by pseudobezoar which is an indigestive object voluntarily introduced into the digestive tract. The term Bezoar is from Arabic bāzahr, “bezoar” or ultimately from Middle Persian pʾtzhl pādzahr, “antidote, bezoar”ægagropile o egagropile It should be a universal antidote that works against any poison, and could neutralize any poison. Otherwise, the name could derive from a kind of Turkish goat whose name is just bezoar. Authors report a case of fecal impaction by pumpkin seeds bezoar with abdominal pain: a difficulty to void with subsequent rectal inflammation and hemorrhoid enlargement was observed. The patient underwent a successful manual disimpaction. Guidelines do not require IRB approval Authors examined the literature about occlusion from bezoar The most common causes of occlusion from bezoar are: a previous gastric surgery such as a gastric band (for weight loss) or gastric bypass, a reduced stomach acid (hypochlorhydria) or decreased stomach size, a delayed gastric emptying, typically due to diabetes, autoimmune disorders, or mixed connective tissue disease. Seed bezoars are usually found in the rectum of patients without predisposing factors, causing constipation and pain. Rectal impaction is common after ingestion of seeds while a true occlusion is rare. Although several cases of phytobezoars composed of various types of seeds are reported in literature, bezoars of pumpkin seeds have rarely been reported.
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- 2023
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3. Polypharmacy Management in Chronic Conditions: A Systematic Literature Review of Italian Interventions
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Lara Perrella, Sara Mucherino, Manuela Casula, Maddalena Illario, Valentina Orlando, and Enrica Menditto
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polypharmacy ,multimorbidity ,adult population ,chronic conditions ,management ,inappropriate polypharmacy ,Medicine - Abstract
Background: Potentially inappropriate polypharmacy (PIP) is among the major factors leading to adverse drug reactions, increased healthcare costs, reduced medication adherence, and worsened patient conditions. This study aims to identify existing interventions implemented to monitor and manage polypharmacy in the Italian setting. Methods: A systematic literature review (PROSPERO: CRD42023457049) was carried out according to the PRISMA statement guidelines. PubMed, Embase, ProQuest, and Web of Science were queried without temporal constraints, encompassing all published papers until October 2023. Inclusion criteria followed the PICO model: patients with polypharmacy; interventions to monitor/manage polypharmacy regimen versus no/any intervention; outcomes in terms of intervention effectiveness and cost variation. Results: After duplicate deletion, 153 potentially relevant publications were extracted. Following abstract and full-text screenings, nine articles met the inclusion criteria. Overall, 78% (n = 7) were observational studies, 11% (n = 1) were experimental studies, and 11% (n = 1) were two-phase studies. A total of 44% (n = 4) of the studies involved patients aged ≥ 65 years, while 56% (n = 5) were disease-specific. Monitoring was the most prevalent choice of intervention (67%; n = 6). Outcomes were mainly related to levels of polypharmacy (29%; n = 6) and comorbidities (29%; n = 6), effectiveness rates (14%; n = 3), and avoidable costs (9%; n = 2). Conclusions: This review outlines that Italy is still lacking in interventions to monitor/manage PIP, addressing an unmet need in developing patient-tailored strategies for reducing health-system burden.
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- 2024
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4. Clinical outcomes of a digitally supported approach for self-management of type 2 diabetes mellitus
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Vincenzo De Luca, Lutgarda Bozzetto, Clemente Giglio, Giovanni Tramontano, Giuseppina De Simone, Antonio Luciano, Luigi Lucibelli, Ada Maffettone, Michele Riccio, Geremia Romano, Ernesto Rossi, Carlos Juan Chiatti, Alexander Berler, Guido Iaccarino, Maddalena Illario, and Giovanni Annuzzi
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digital health ,mHealth ,type 2 diabetes mellitus ,self-management ,patient empowerment ,telemedicine ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundSelf-management of Type 2 diabetes mellitus (T2D) is challenging. Regular self-monitoring of blood glucose and healthy lifestyles are required to improve glycometabolic control, thus delaying diabetes complications, and reducing hospitalizations. Digital technologies can empower patients in their disease management promoting self-management and motivation to change behaviors. We report the results of an exploratory trial aimed at evaluating the metabolic outcomes of using digital solutions for T2D self-management developed in the ProEmpower project, a European Commission funded Pre-Commercial Procurement.MethodsTwo digital solutions, DM4All and DiaWatch, which were codesigned with providers, patients, and caregivers, enabled the collection of clinical parameters by the patient using a smartphone integrated with the medical devices (glucometer, sphygmomanometer, scale, smart watch for heart rate monitoring and step counter). Data were automatically sent to the shared care plan allowing professionals to monitor adherence to treatment, set goals, and communicate more effectively with patients. At baseline and after an average follow-up of 8 months, glycosylated hemoglobin (HbA1c), body weight, blood pressure, and blood lipids were measured in 100 T2D patients using the ProEmpower solutions across different diabetes centers in Campania Region, age 45–79 years, both genders, and compared with a Control cohort of T2D patients (n = 100) with similar clinical characteristics and followed for a comparable period of observation in the same centers.ResultsAt baseline, the ProEmpower participants and the Control subjects were on average overweight, with a similar BMI in the two cohorts, and mean HbA1c was at acceptable levels (around 7.0%). After the 8 month exploratory trial, body weight, HbA1c, systolic and diastolic blood pressure, and plasma and LDL-cholesterol significantly decreased in the ProEmpower participants compared to baseline (p
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- 2023
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5. Innovative approaches to service integration addressing the unmet needs of irritable bowel syndrome patients and new approaches for the needs of IBS patients
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Maurizio Gentile, Vincenzo De Luca, Roberta Patalano, Daniela Laudisio, Giovanni Tramontano, Sonja Lindner-Rabl, Lorenzo Mercurio, Elena Salvatore, John Farrell, Regina Roller-Wirnsberger, Lutz Kubitschke, Maria Triassi, Annamaria Colao, Maddalena Illario, and Vigour Consortium
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irritable bowel syndrome ,mHealth ,digital health ,nutrition ,physical activity ,Medicine (General) ,R5-920 - Abstract
BackgroundIrritable bowel syndrome (IBS) is a common multifactorial condition that affects the large intestine and is characterized by chronic and relapsing abdominal pain and altered bowel habit. IBS is due to a combination of genetic, environmental and dietary factors. It's usually a lifelong problem very frustrating to live with and can have a big impact on quality of life, as single-agent therapy ra.ObjectiveTo analyze the approaches and solutions that address the social and health unmet needs of patients with IBS.DesignA quantitative-qualitative approach was adopted in the current study to identify and specify key digital solution and high impact user scenarios applied to IBS patients, through an adaptation of the “Blueprint on Digital Transformation in Health and Care in an Ageing Society” persona methodology.SettingsDigital health solutions bring the potential of supporting health interventions through mobile apps, wearable devices, telemedicine.PatientsA Survey was administered to a group of patients in an anonymous form, and no need for Medical Ethical Committee approval was identified.InterventionsThe theoretical elaboration IBS personas was developed through an interdisciplinary Focus Group, which also mapped the pathway for the patient's management.Main outcomeThree main needs were identified to be met to improve IBS patient's lifestyle: access to psychological support, mHealth solutions supporting diet and adapted physical activity, and home-based digital health support. mHealth intervention has been identified for diet adherence, physical exercise and psychological well-being. The process has been mapped and adapted to integrate the new solutions into the care pathway.LimitationFurther research is needed to evaluate how mHealth services enable IBS patients to manage their conditions and improve their quality of life.ConclusionThe person-centered approach was implemented through a multidisciplinary Focus group that enabled the identification of the need for a mHealth intervention.
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- 2022
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6. Emergent dwelling. Requests for designing a human-scale and climate-proof lifetime house
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Erminia Attaianese, Maddalena Illario, and Marina Rigillo
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Environmental Design ,Smart Building ,Green Building ,Person-Centred Approach ,Life-Course Approach to Ageing ,Aesthetics of cities. City planning and beautifying ,NA9000-9428 ,Architectural drawing and design ,NA2695-2793 - Abstract
This contribution presents part of the results produced by the University of Naples Federico II in the project PRIN 2017 TECH-START. The research investigates how the challenges of the circular economy and climate mitigation, combined with digital technologies, require new organisations for contemporary dwelling, including the need for healthy and safe environments. The contribution studies the concept of emergent dwelling with the aim of achieving a set of design requirements consistent with the many, diverse forms of living. These requirements apply to the project of a multigenerational lifetime house, selecting those most suitable for a smart residency that integrates the socio-productive and health care chain into the territory, with particular reference to the elderly population and the most fragile groups in a life-course perspective.
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- 2022
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7. Chefs in Future Integrated Healthcare – Current State and Innovation Needs: A First Overview of the NECTAR Project (aN Eu Curriculum for Chef gasTro-Engineering in Primary Food Care)
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Marjolein Winters, Valentina Wagner, Roberta Patalano, Sonja Lindner, Serena Alvino, Regina Roller-Wirnsberger, Heidemarie Müller-Riedlhuber, Sandra Pais, Matilde Borriello, John Farrel, Geertrui Vlaemynck, Martijn van Gemst, Bart Geurden, Lobke Van den Wijngaert, Edwig Goossens, Maddalena Illario, and Carolin Herzog
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integrated health care systems ,chef ,vocational education and training (vet) ,interprofessional ,food ,nutrition ,malnutrition ,Medicine (General) ,R5-920 - Abstract
People in need of care, chronic or acute, often present problematic food intake and special nutritional needs. Integrated, person-centred and pro-active food and nutritional care delivery has been proven effective for people in health care. However, skills mismatches have been reported in different professions involved, which also applies to the role of chefs in healthcare. The EU funded project NECTAR aims at closing this gap by creating a new job profile, called Chef Gastro-Engineering (CGE). The current publication summarizes the status quo in hospitals and gives a perspective on the future role of chefs in integrated healthcare delivery.
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- 2022
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8. Is diet partly responsible for differences in COVID-19 death rates between and within countries?
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Jean Bousquet, Josep M. Anto, Guido Iaccarino, Wienczyslawa Czarlewski, Tari Haahtela, Aram Anto, Cezmi A. Akdis, Hubert Blain, G. Walter Canonica, Victoria Cardona, Alvaro A. Cruz, Maddalena Illario, Juan Carlos Ivancevich, Marek Jutel, Ludger Klimek, Piotr Kuna, Daniel Laune, Désirée Larenas-Linnemann, Joaquim Mullol, Nikos G. Papadopoulos, Oliver Pfaar, Boleslaw Samolinski, Arunas Valiulis, Arzu Yorgancioglu, Torsten Zuberbier, and The ARIA group
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Coronavirus ,Diet ,Angiotensin-converting enzyme ,Antioxidant ,Food ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.
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- 2020
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9. Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries?
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Jean Bousquet, Josep M. Anto, Guido Iaccarino, Wienczyslawa Czarlewski, Tari Haahtela, Aram Anto, Cezmi A. Akdis, Hubert Blain, G. Walter Canonica, Victoria Cardona, Alvaro A. Cruz, Maddalena Illario, Juan Carlos Ivancevich, Marek Jutel, Ludger Klimek, Piotr Kuna, Daniel Laune, Désirée Larenas‑Linnemann, Joaquim Mullol, Nikos G. Papadopoulos, Oliver Pfaar, Boleslaw Samolinski, Arunas Valiulis, Arzu Yorgancioglu, Torsten Zuberbier, and The ARIA group
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Immunologic diseases. Allergy ,RC581-607 - Abstract
An amendment to this paper has been published and can be accessed via the original article.
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- 2020
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10. 'One Health' Approach for Health Innovation and Active Aging in Campania (Italy)
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Vincenzo De Luca, Giovanni Tramontano, Luigi Riccio, Ugo Trama, Pietro Buono, Mario Losasso, Umberto Marcello Bracale, Giovanni Annuzzi, Rosa Zampetti, Francesco Cacciatore, Giannamaria Vallefuoco, Alberto Lombardi, Anna Marro, Mariarosa Anna Beatrice Melone, Cristina Ponsiglione, Maria Luisa Chiusano, Giancarlo Bracale, Gaetano Cafiero, Aurelio Crudeli, Carmine Vecchione, Maurizio Taglialatela, Donatella Tramontano, Guido Iaccarino, Maria Triassi, Regina Roller-Wirnsberger, Jean Bousquet, and Maddalena Illario
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health policy ,digital health ,active and healthy aging ,health innovation ,future health and health care ,information and communication technologies ,Public aspects of medicine ,RA1-1270 - Abstract
This article describes how innovations are exploited in Campania (Italy) to improve health outcomes, quality of life, and sustainability of social and healthcare services. Campania's strategy for digitalization of health and care and for healthy aging is based on a person-centered, life-course, “One Health” approach, where demographic change is considered capable of stimulating a growth dynamic linked to the opportunities of combining the “Silver Economy” with local assets and the specific health needs of the population. The end-users (citizens, patients, and professionals) contribute to the co-creation of products and services, being involved in the identification of unmet needs and test-bed activity. The Campania Reference Site of the European Innovation Partnership on Active and Healthy Aging is a flexible regional ecosystem to address the challenge of an aging population with a life-course approach. The good practices, developed in the context of research and innovation projects and innovative procurements by local stakeholders and collaborations with international networks, have been allowing the transfer of innovative solutions, knowledge, and skills to the stakeholders of such a multi-sectoral ecosystem for health.
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- 2021
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11. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases
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J. Jean Bousquet, Holger J. Schünemann, Alkis Togias, Marina Erhola, Peter W. Hellings, Torsten Zuberbier, Ioana Agache, Ignacio J. Ansotegui, Josep M. Anto, Claus Bachert, Sven Becker, Martin Bedolla-Barajas, Michael Bewick, Sinthia Bosnic-Anticevich, Isabelle Bosse, Louis P. Boulet, Jean Marc Bourrez, Guy Brusselle, Niels Chavannes, Elisio Costa, Alvaro A. Cruz, Wienczyslawa Czarlewski, Wytske J. Fokkens, Joao A. Fonseca, Mina Gaga, Tari Haahtela, Maddalena Illario, Ludger Klimek, Piotr Kuna, Violeta Kvedariene, L. T. T. Le, Desiree Larenas-Linnemann, Daniel Laune, Olga M. Lourenço, Enrica Menditto, Joaquin Mullol, Yashitaka Okamoto, Nikos Papadopoulos, Nhân Pham-Thi, Robert Picard, Hilary Pinnock, Nicolas Roche, Regina E. Roller-Wirnsberger, Christine Rolland, Boleslaw Samolinski, Aziz Sheikh, Sanna Toppila-Salmi, Ioanna Tsiligianni, Arunas Valiulis, Erkka Valovirta, Tuula Vasankari, Maria-Teresa Ventura, Samantha Walker, Sian Williams, Cezmi A. Akdis, Isabella Annesi-Maesano, Sylvie Arnavielhe, Xavier Basagana, Eric Bateman, Anna Bedbrook, K. S. Bennoor, Samuel Benveniste, Karl C. Bergmann, Slawomir Bialek, Nils Billo, Carsten Bindslev-Jensen, Leif Bjermer, Hubert Blain, Mateo Bonini, Philippe Bonniaud, Jacques Bouchard, Vitalis Briedis, Christofer E. Brightling, Jan Brozek, Roland Buhl, Roland Buonaiuto, Giorgo W. Canonica, Victoria Cardona, Ana M. Carriazo, Warner Carr, Christine Cartier, Thomas Casale, Lorenzo Cecchi, Alfonso M. Cepeda Sarabia, Eka Chkhartishvili, Derek K. Chu, Cemal Cingi, Elaine Colgan, Jaime Correia de Sousa, Anne Lise Courbis, Adnan Custovic, Biljana Cvetkosvki, Gennaro D’Amato, Jane da Silva, Carina Dantas, Dejand Dokic, Yves Dauvilliers, Antoni Dedeu, Giulia De Feo, Philippe Devillier, Stefania Di Capua, Marc Dykewickz, Ruta Dubakiene, Motohiro Ebisawa, Yaya El-Gamal, Esben Eller, Regina Emuzyte, John Farrell, Antjie Fink-Wagner, Alessandro Fiocchi, Jean F. Fontaine, Bilun Gemicioğlu, Peter Schmid-Grendelmeir, Amiran Gamkrelidze, Judith Garcia-Aymerich, Maximiliano Gomez, Sandra González Diaz, Maia Gotua, Nick A. Guldemond, Maria-Antonieta Guzmán, Jawad Hajjam, John O’B Hourihane, Marc Humbert, Guido Iaccarino, Despo Ierodiakonou, Juan C. Ivancevich, Guy Joos, Ki-Suck Jung, Marek Jutel, Igor Kaidashev, Omer Kalayci, Przemyslaw Kardas, Thomas Keil, Mussa Khaitov, Nikolai Khaltaev, Jorg Kleine-Tebbe, Marek L. Kowalski, Vicky Kritikos, Inger Kull, Lisa Leonardini, Philip Lieberman, Brian Lipworth, Karin C. Lodrup Carlsen, Claudia C. Loureiro, Renaud Louis, Alpana Mair, Gert Marien, Bassam Mahboub, Joao Malva, Patrick Manning, Esteban De Manuel Keenoy, Gailen D. Marshall, Mohamed R. Masjedi, Jorge F. Maspero, Eve Mathieu-Dupas, Poalo M. Matricardi, Eric Melén, Elisabete Melo-Gomes, Eli O. Meltzer, Jacques Mercier, Neven Miculinic, Florin Mihaltan, Branislava Milenkovic, Giuliana Moda, Maria-Dolores Mogica-Martinez, Yousser Mohammad, Steve Montefort, Ricardo Monti, Mario Morais-Almeida, Ralf Mösges, Lars Münter, Antonella Muraro, Ruth Murray, Robert Naclerio, Luigi Napoli, Leila Namazova-Baranova, Hugo Neffen, Kristoff Nekam, Angelo Neou, Enrico Novellino, Dieudonné Nyembue, Robin O’Hehir, Ken Ohta, Kimi Okubo, Gabrielle Onorato, Solange Ouedraogo, Isabella Pali-Schöll, Susanna Palkonen, Peter Panzner, Hae-Sim Park, Jean-Louis Pépin, Ana-Maria Pereira, Oliver Pfaar, Ema Paulino, Jim Phillips, Davor Plavec, Ted A. Popov, Fabienne Portejoie, David Price, Emmanuel P. Prokopakis, Benoit Pugin, Filip Raciborski, Rojin Rajabian-Söderlund, Sietze Reitsma, Xavier Rodo, Antonino Romano, Nelson Rosario, Menahenm Rottem, Dermot Ryan, Johanna Salimäki, Mario M. Sanchez-Borges, Juan-Carlos Sisul, Dirceu Solé, David Somekh, Talant Sooronbaev, Milan Sova, Otto Spranger, Cristina Stellato, Rafael Stelmach, Charlotte Suppli Ulrik, Michel Thibaudon, Teresa To, Ana Todo-Bom, Peter V. Tomazic, Antonio A. Valero, Rudolph Valenta, Marylin Valentin-Rostan, Rianne van der Kleij, Olivier Vandenplas, Giorgio Vezzani, Frédéric Viart, Giovanni Viegi, Dana Wallace, Martin Wagenmann, De Y. Wang, Susan Waserman, Magnus Wickman, Dennis M. Williams, Gary Wong, Piotr Wroczynski, Panayiotis K. Yiallouros, Arzu Yorgancioglu, Osman M. Yusuf, Heahter J. Zar, Stéphane Zeng, Mario Zernotti, Luo Zhang, Nan S. Zhong, Mihaela Zidarn, the ARIA Study Group, and the MASK Study Group
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Health care transformation ,Care pathways ,Rhinitis ,ARIA ,MASK ,POLLAR ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Background In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted “patient activation”, (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
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- 2019
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12. Can Integrated Care Help in Meeting the Challenges Posed on Our Health Care Systems by COVID-19? Some Preliminary Lessons Learned from the European VIGOUR Project
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Sonja Lindner, Lutz Kubitschke, Christos Lionis, Marilena Anastasaki, Ursula Kirchmayer, Simona Giacomini, Vincenzo De Luca, Guido Iaccarino, Maddalena Illario, Antonio Maddalena, Antonio Maritati, Diego Conforti, Isabella Roba, Daniele Musian, Antonio Cano, Monica Granell, Ana M. Carriazo, Carmen M. Lama, Susana Rodríguez, Agnieszka Guligowska, Tomasz Kostka, Annemieke Konijnendijk, Maria Vitullo, Alejandro García-Rudolph, Javier Solana Sánchez, Marcello Maggio, Giuseppe Liotta, Chariklia Tziraki, Regina Roller-Wirnsberger, and on behalf of the VIGOUR consortium
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integrated care ,covid-19 ,pandemic management ,vulnerable patients ,health care ,social care ,Medicine (General) ,R5-920 - Abstract
The COVID-19 pandemic puts health and care systems under pressure globally. This current paper highlights challenges arising in the care for older and vulnerable populations in this context and reflects upon possible perspectives for different systems making use of nested integrated care approaches adapted during the work of the EU-funded project VIGOUR (“Evidence based Guidance to Scale-up Integrated Care in Europe”, funded by the European Union’s Health Programme 2014–2020 under Grant Agreement Number 826640).
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- 2020
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13. European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases: report of the European Union Parliament Summit (29 March 2017)
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Peter W. Hellings, David Borrelli, Sirpa Pietikainen, Ioana Agache, Cezmi Akdis, Claus Bachert, Michael Bewick, Erna Botjes, Jannis Constantinidis, Wytske Fokkens, Tari Haahtela, Claire Hopkins, Maddalena Illario, Guy Joos, Valerie Lund, Antonella Muraro, Benoit Pugin, Sven Seys, David Somekh, Pär Stjärne, Arunas Valiulis, Erkka Valovirta, and Jean Bousquet
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Advocacy ,EUFOREA ,Asthma ,Mobile health technology ,Allergy ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract On March 29, 2017, a European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases (CRD) was organized by the European Forum for Research and Education in Allergy and Airway Diseases. The event took place in the European Parliament of Brussels and was hosted by MEP David Borrelli and MEP Sirpa Pietikainen. The aim of the Summit was to correspond to the needs of the European Commission and of patients suffering from CRD to join forces in Europe for the prevention and self-management. Delegates of the European Rhinologic Society, European Respiratory Society, European Academy of Allergy and Clinical Immunology, European Academy of Paediatrics, and European Patients Organization EFA all lectured on their vision and action plan to join forces in achieving adequate prevention and self-management of CRD in the context of Precision Medicine. Recent data highlight the preventive capacity of education on optimal care pathways for CRD. Self-management and patient empowerment can be achieved by novel educational on-line materials and by novel mobile health tools enabling patients and doctors to monitor and optimally treat CRDs based on the level of control. This report summarizes the contributions of the representatives of different European academic stakeholders in the field of CRD.
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- 2017
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14. Creating a Culture of Health in Planning and Implementing Innovative Strategies Addressing Non-communicable Chronic Diseases
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Chariklia Tziraki-Segal, Vincenzo De Luca, Silvina Santana, Rosa Romano, Giovanni Tramontano, Paola Scattola, Corrado Celata, Giusi Gelmi, Sara Ponce Márquez, Luz Lopez-Samaniego, Veronica Zavagli, Arja Halkoaho, Corrina Grimes, Maria Teresa Tomás, Beatriz Fernandes, Laura Calzà, Patrizia Speranza, Liliana Coppola, Harriët Jager-Wittenaar, Rónán O'Caoimh, Anna-Maija Pietilä, Ana Maria Carriazo, Joao Apostolo, Guido Iaccarino, Giuseppe Liotta, Donatella Tramontano, William Molloy, Maria Triassi, Vincenzo Viggiani, and Maddalena Illario
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culture of health ,active and healthy aging ,inclusive health care ,salutogenesis ,health innovation ,Sociology (General) ,HM401-1281 - Abstract
Ongoing demographic changes are challenging health systems worldwide especially in relation to increasing longevity and the resultant rise of non-communicable diseases (NCDs). To meet these challenges, a paradigm shift to a more proactive approach to health promotion, and maintenance is needed. This new paradigm focuses on creating and implementing an ecological model of Culture of Health. The conceptualization of the Culture of Health is defined as one where good health and well-being flourish across geographic, demographic, and social sectors; fostering healthy equitable communities where citizens have the opportunity to make choices and be co-producers of healthy lifestyles. Based on Antonovsky's Salutogenesis model which asserts that the experience of health moves along a continuum across the lifespan, we will identify the key drivers for achieving a Culture of Health. These include mindset/expectations, sense of community, and civic engagement. The present article discusses these drivers and identifies areas where policy and research actions are needed to advance positive change on population health and well-being. We highlight empirical evidence of drivers within the EU guided by the activities within the thematic Action Groups of the European Innovation Partnership on Active and Healthy Aging (EIP on AHA), focusing on Lifespan Health Promotion and Prevention of Age-Related Frailty and Disease (A3 Action Group). We will specifically focus on the effect of Culture on Health, highlighting cross-cutting drivers across domains such as innovations at the individual and community level, and in synergies with business, policy, and research entities. We will present examples of drivers for creating a Culture of Health, the barriers, the remaining gaps, and areas of future research to achieve an inclusive and sustainable asset-based community.
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- 2019
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15. GRKs and β-Arrestins: 'Gatekeepers' of Mitochondrial Function in the Failing Heart
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Daniela Sorriento, Jessica Gambardella, Antonella Fiordelisi, Guido Iaccarino, and Maddalena Illario
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G protein-coupled receptor kinase 2 ,β-arrestins ,mitochondria ,heart failure ,cardiac damage ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Mitochondrial regulation of energy production, calcium homeostasis, and cell death are critical for cardiac function. Accordingly, the structural and functional abnormalities of these organelles (mitochondrial dysfunction) contribute to developing cardiovascular diseases and heart failure. Therefore the preservation of mitochondrial integrity is essential for cardiac cell survival. Mitochondrial function is regulated by several proteins, including GRK2 and β-arrestins which act in a GPCR independent manner to orchestrate intracellular signaling associated with key mitochondrial processes. It is now ascertained that GRK2 is able to recover mitochondrial function in response to insults. β-arrestins affect several intracellular signaling pathways within the cell which in turn are involved in the regulation of mitochondrial function, but a direct regulation of mitochondria needs further investigations. In this review, we discuss the recent acquisitions on the role of GRK2 and β-arrestins in the regulation of mitochondrial function.
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- 2019
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16. Exploiting GRK2 Inhibition as a Therapeutic Option in Experimental Cancer Treatment: Role of p53-Induced Mitochondrial Apoptosis
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Jessica Gambardella, Antonella Fiordelisi, Gaetano Santulli, Michele Ciccarelli, Federica Andrea Cerasuolo, Marina Sala, Eduardo Sommella, Pietro Campiglia, Maddalena Illario, Guido Iaccarino, and Daniela Sorriento
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GRK2 ,p53 ,thyroid cancer ,mitochondrial apoptosis ,GRK2 inhibition ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
The involvement of GRK2 in cancer cell proliferation and its counter-regulation of p53 have been suggested in breast cancer even if the underlying mechanism has not yet been elucidated. Furthermore, the possibility to pharmacologically inhibit GRK2 to delay cancer cell proliferation has never been explored. We investigated this possibility by setting up a study that combined in vitro and in vivo models to underpin the crosstalk between GRK2 and p53. To reach this aim, we took advantage of the different expression of p53 in cell lines of thyroid cancer (BHT 101 expressing p53 and FRO cells, which are p53-null) in which we overexpressed or silenced GRK2. The pharmacological inhibition of GRK2 was achieved using the specific inhibitor KRX-C7. The in vivo study was performed in Balb/c nude mice, where we treated BHT-101 or FRO-derived tumors with KRX-C7. In our in vitro model, FRO cells were unaffected by GRK2 expression levels, whereas BHT-101 cells were sensitive, thus suggesting a role for p53. The regulation of p53 by GRK2 is due to phosphorylative events in Thr-55, which induce the degradation of p53. In BHT-101 cells, the pharmacologic inhibition of GRK2 by KRX-C7 increased p53 levels and activated apoptosis through the mitochondrial release of cytochrome c. These KRX-C7-mediated events were also confirmed in cancer allograft models in nude mice. In conclusion, our data showed that GRK2 counter-regulates p53 expression in cancer cells through a kinase-dependent activity. Our results further corroborate the anti-proliferative role of GRK2 inhibitors in p53-sensitive tumors and propose GRK2 as a therapeutic target in selected cancers.
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- 2020
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17. Monitoring Biochemical and Structural Changes in Human Periodontal Ligaments during Orthodontic Treatment by Means of Micro-Raman Spectroscopy
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Letizia Perillo, Fabrizia d’Apuzzo, Maddalena Illario, Luigi Laino, Gaetano Di Spigna, Maria Lepore, and Carlo Camerlingo
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periodontal ligament ,orthodontic tooth movement ,raman spectroscopy ,proteins ,ch2 and ch3 modes ,Chemical technology ,TP1-1185 - Abstract
The aim of the study was to examine the biochemical and structural changes occurring in the periodontal ligament (PDL) during orthodontic-force application using micro-Raman spectroscopy ( μ -RS). Adolescent and young patients who needed orthodontic treatment with first premolar extractions were recruited. Before extractions, orthodontic forces were applied using a closed-coil spring that was positioned between the molar and premolar. Patients were randomly divided into three groups, whose extractions were performed after 2, 7, and 14 days of force application. From the extracted premolars, PDL samples were obtained, and a fixation procedure with paraformaldehyde was adopted. Raman spectra were acquired for each PDL sample in the range of 1000−3200 cm − 1 and the more relevant vibrational modes of proteins (Amide I and Amide III bands) and CH 2 and CH 3 modes were shown. Analysis indicated that the protein structure in the PDL samples after different time points of orthodontic-force application was modified. In addition, changes were observed in the CH 2 and CH 3 high wavenumber region due to local hypoxia and mechanical force transduction. The reported results indicated that μ -RS provides a valuable tool for investigating molecular interchain interactions and conformational modifications in periodontal fibers after orthodontic tooth movement, providing quantitative insight of time occurring for PDL molecular readjustment.
- Published
- 2020
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18. The Quadruple Helix-Based Innovation Model of Reference Sites for Active and Healthy Ageing in Europe: The Ageing@Coimbra Case Study
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João O. Malva, Alda Amado, Alexandra Rodrigues, Anabela Mota-Pinto, Ana F. Cardoso, Ana M. Teixeira, Ana Todo-Bom, António Devesa, António F. Ambrósio, António L. Cunha, Bárbara Gomes, Carina Dantas, Cidalina Abreu, Isabel Santana, Jean Bousquet, João Apóstolo, Lúcia Santos, Lúcio Meneses de Almeida, Maddalena Illario, Rafaela Veríssimo, Vitor Rodrigues, and Manuel T. Veríssimo
- Subjects
ageing (aging) ,European commission ,innovation ,active and healthy aging ,reference sites ,Medicine (General) ,R5-920 - Abstract
Challenges posed by demographic changes and population aging are key priorities for the Horizon 2020 Program of the European Commission. Aligned with the vision of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA), the development, exchange, and large-scale adoption of innovative good practices is a key element of the responses required to ensure all European citizens remain as active and healthy as possible as they age. Urged by the need of developing scalable disruptive innovation across Europe, the European Commission and the EIP on AHA created the Reference Sites; local coalition of partners that develop good practices to support AHA. Ageing@Coimbra is an example of how this can be achieved at a regional level. The consortium comprises over 70 institutions that develop innovative practices to support AHA in Portugal. Ageing@Coimbra partners support a regional network of stakeholders that build a holistic ecosystem in health and social care, taking into consideration the specificities of the territories, living environments and cultural resources (2,243,934 inhabitants, 530,423 aged 65 or plus live in the Centre Region of Portugal). Good practices in reducing the burden of brain diseases that affect cognition and memory impairment in older people and tackling social isolation in urban and rural areas are among the top priorities of Ageing@Coimbra. Profiting from the collaborative work of academia, business companies, civil society, and authorities, the quadruple helix of Ageing@Coimbra supports: early diagnosis of frailty and disease; care and cure; and active, assisted, and independent living. This paper describes, as a Community Case Study, the creation of a Reference Site of the EIP on AHA, Ageing@Coimbra, and its impact in Portugal. This Reference Site can motivate other regions to develop innovative formulas to federate stakeholders and networks, building consortia at regional level. This growing movement, across Europe, is inspired by the quadruple helix concept and by the replication of innovative good practices; creating new Reference Sites for the benefit of Citizens.
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- 2018
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19. Active Ageing in Europe: Adding Healthy Life to Years
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Giuseppe Liotta, Helena Canhao, Fabian Cenko, Rita Cutini, Ercole Vellone, Maddalena Illario, Przemyslaw Kardas, Andrea Poscia, Rute Dinis Sousa, Leonardo Palombi, and Maria Cristina Marazzi
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active and healthy ageing ,Europe ,healthy life years ,blue print initiative ,frailty ,Medicine (General) ,R5-920 - Published
- 2018
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20. A case study of polypharmacy management in nine European countries: Implications for change management and implementation.
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Jennifer McIntosh, Albert Alonso, Katie MacLure, Derek Stewart, Thomas Kempen, Alpana Mair, Margarida Castel-Branco, Carles Codina, Fernando Fernandez-Llimos, Glenda Fleming, Dimitra Gennimata, Ulrika Gillespie, Cathy Harrison, Maddalena Illario, Ulrike Junius-Walker, Christos F Kampolis, Przemyslaw Kardas, Pawel Lewek, João Malva, Enrica Menditto, Claire Scullin, Birgitt Wiese, and SIMPATHY Consortium
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Medicine ,Science - Abstract
Multimorbidity and its associated polypharmacy contribute to an increase in adverse drug events, hospitalizations, and healthcare spending. This study aimed to address: what exists regarding polypharmacy management in the European Union (EU); why programs were, or were not, developed; and, how identified initiatives were developed, implemented, and sustained.Change management principles (Kotter) and normalization process theory (NPT) informed data collection and analysis. Nine case studies were conducted in eight EU countries: Germany (Lower Saxony), Greece, Italy (Campania), Poland, Portugal, Spain (Catalonia), Sweden (Uppsala), and the United Kingdom (Northern Ireland and Scotland). The workflow included a review of country/region specific polypharmacy policies, key informant interviews with stakeholders involved in policy development and implementation and, focus groups of clinicians and managers. Data were analyzed using thematic analysis of individual cases and framework analysis across cases.Polypharmacy initiatives were identified in five regions (Catalonia, Lower Saxony, Northern Ireland, Scotland, and Uppsala) and included all care settings. There was agreement, even in cases without initiatives, that polypharmacy is a significant issue to address. Common themes regarding the development and implementation of polypharmacy management initiatives were: locally adapted solutions, organizational culture supporting innovation and teamwork, adequate workforce training, multidisciplinary teams, changes in workflow, redefinition of roles and responsibilities of professionals, policies and legislation supporting the initiative, and data management and information and communication systems to assist development and implementation. Depending on the setting, these were considered either facilitators or barriers to implementation.Within the studied EU countries, polypharmacy management was not widely addressed. These results highlight the importance of change management and theory-based implementation strategies, and provide examples of polypharmacy management initiatives that can assist managers and policymakers in developing new programs or scaling up existing ones, particularly in places currently lacking such initiatives.
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- 2018
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21. NutriLive: An Integrated Nutritional Approach as a Sustainable Tool to Prevent Malnutrition in Older People and Promote Active and Healthy Ageing—The EIP-AHA Nutrition Action Group
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Maddalena Illario, Angela Serena Maione, Maria Rosaria Rusciano, Edwig Goossens, Amelia Rauter, Nidia Braz, Harriet Jager-Wittenaar, Carolina Di Somma, Catherine Crola, Maria Soprano, Laura Vuolo, Pietro Campiglia, Guido Iaccarino, Helen Griffiths, Tobias Hartman, Donatella Tramontano, Annamaria Colao, and Regina Roller-Wirnsberger
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Public aspects of medicine ,RA1-1270 - Abstract
The present document describes a nutritional approach that is nested in the European Innovation Partnership for Active and Healthy Aging (EIP-AHA) and aims to provide the first common European program translating an integrated approach to nutritional frailty in terms of a multidimensional and transnational methodology. The document has been developed by the A3 Nutrition Action Area of the EIP-AHA and aims at providing a stepwise approach to malnutrition in older citizens, identifying adequate interventions based on a unified assessment and ICT-supported solutions. “NutriLive” is an integrated nutritional approach, represented by a structured Screening-Assessment-Monitoring-Action-Pyramid-Model (SAM-AP). Its core concept is the stratification of the nutritional needs, considered by the working group as the key for targeted, effective, and sustainable interventions. “NutriLive” tries to close gaps in epidemiological data within an aging population, creating a unified language to deal with the topic of nutrition and malnutrition in Europe. By assembling all the validated screening, assessment, and monitoring tools on malnutrition in a first pyramid, which is interrelated to a second intervention pyramid, the A3 Nutrition WG identifies a common, integrated vision on the nutritional approach to frailty, which applies to the various health care settings.
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- 2016
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22. Active and Healthy Ageing and Independent Living 2016
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Maddalena Illario, Miriam M. R. Vollenbroek-Hutten, D. William Molloy, Enrica Menditto, Guido Iaccarino, and Patrik Eklund
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Geriatrics ,RC952-954.6 - Published
- 2016
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23. Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells.
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Maria Soprano, Daniela Sorriento, Maria Rosaria Rusciano, Angela Serena Maione, Gennaro Limite, Pietro Forestieri, Dario D'Angelo, Matteo D'Alessio, Pietro Campiglia, Pietro Formisano, Guido Iaccarino, Roberto Bianco, and Maddalena Illario
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Medicine ,Science - Abstract
The discovery of the anti-proliferative activity of nelfinavir in HIV-free models has encouraged its investigation as anticancer drug. Although the molecular mechanism by which nelfinavir exerts antitumor activity is still unknown, its effects have been related to Akt inhibition. Here we tested the effects of nelfinavir on cell proliferation, viability and death in two human breast cancer cell lines and in human normal primary breast cells. To identify the mechanism of action of nelfinavir in breast cancer, we evaluated the involvement of the Akt pathway as well as the effects of nelfinavir on reactive oxygen species (ROS) production and ROS-related enzymes activities. Nelfinavir reduced breast cancer cell viability by inducing apoptosis and necrosis, without affecting primary normal breast cells. The antitumor activity of nelfinavir was related to alterations of the cell redox state, coupled with an increase of intracellular ROS production limited to cancer cells. Nelfinavir treated tumor cells also displayed a downregulation of the Akt pathway due to disruption of the Akt-HSP90 complex, and subsequent degradation of Akt. These effects resulted to be ROS dependent, suggesting that ROS production is the primary step of nelfinavir anticancer activity. The analysis of ROS-producers and ROS-detoxifying enzymes revealed that nelfinavir-mediated ROS production was strictly linked to flavoenzymes activation. We demonstrated that ROS enhancement represents the main molecular mechanism required to induce cell death by nelfinavir in breast cancer cells, thus supporting the development of new and more potent oxidizing molecules for breast cancer therapy.
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- 2016
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24. The Impact of Social and Cultural Engagement and Dieting on Well-Being and Resilience in a Group of Residents in the Metropolitan Area of Naples
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Antonio Rapacciuolo, Pasquale Perrone Filardi, Rosario Cuomo, Vincenzo Mauriello, Maria Quarto, Annamaria Kisslinger, Gianluigi Savarese, Maddalena Illario, and Donatella Tramontano
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Geriatrics ,RC952-954.6 - Abstract
Social isolation and exclusion are associated with poor health status and premature death. A number of related isolation factors, inadequate transportation system and restrictions in individuals’ life space, have been associated with malnutrition in older adults. Since eating is a social event, isolation can have a negative effect on nutrition. Cultural involvement and participation in interactive activities are essential tools to fight social isolation, and they can counteract the detrimental effects of social isolation on health. To provide data supporting the hypothesis that encouraging participation might represent an innovative preventive and health promoting strategy for healthy living and aging, we developed an ad hoc questionnaire to investigate the relationship between cultural participation, well-being, and resilience in a sample of residents in the metropolitan area of Naples. The questionnaire includes a question on adherence to diet or to a special nutritional regimen; in addition, the participants are asked to mention their height and weight. We investigated the relationship between BMI, adherence to diet, and perceived well-being (PWB) and resilience in a sample of 571 subjects over 60 years of age. Here, we present evidence that engagement into social and cultural activities is associated with higher well-being and resilience, in particular in females over 60 years of age.
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- 2016
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25. The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors
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Daniela Sorriento, Gaetano Santulli, Michele Ciccarelli, Angela Serena Maione, Maddalena Illario, Bruno Trimarco, and Guido Iaccarino
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cardiac hypertrophy ,transcription factors ,calmodulin ,GRK ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
We have recently demonstrated that the amino-terminal domain of G protein coupled receptor kinase (GRK) type 5, (GRK5-NT) inhibits NFκB activity in cardiac cells leading to a significant amelioration of LVH. Since GRK5-NT is known to bind calmodulin, this study aimed to evaluate the functional role of GRK5-NT in the regulation of calcium-calmodulin-dependent transcription factors. We found that the overexpression of GRK5-NT in cardiomyoblasts significantly reduced the activation and the nuclear translocation of NFAT and its cofactor GATA-4 in response to phenylephrine (PE). These results were confirmed in vivo in spontaneously hypertensive rats (SHR), in which intramyocardial adenovirus-mediated gene transfer of GRK5-NT reduced both wall thickness and ventricular mass by modulating NFAT and GATA-4 activity. To further verify in vitro the contribution of calmodulin in linking GRK5-NT to the NFAT/GATA-4 pathway, we examined the effects of a mutant of GRK5 (GRK5-NTPB), which is not able to bind calmodulin. When compared to GRK5-NT, GRK5-NTPB did not modify PE-induced NFAT and GATA-4 activation. In conclusion, this study identifies a double effect of GRK5-NT in the inhibition of LVH that is based on the regulation of multiple transcription factors through means of different mechanisms and proposes the amino-terminal sequence of GRK5 as a useful prototype for therapeutic purposes.
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- 2018
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26. Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy.
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Ersilia Cipolletta, Maria Rosaria Rusciano, Angela Serena Maione, Gaetano Santulli, Daniela Sorriento, Carmine Del Giudice, Michele Ciccarelli, Antonietta Franco, Catherine Crola, Pietro Campiglia, Marina Sala, Isabel Gomez-Monterrey, Nicola De Luca, Bruno Trimarco, Guido Iaccarino, and Maddalena Illario
- Subjects
Medicine ,Science - Abstract
Activation of Ca2+/Calmodulin protein kinase II (CaMKII) is an important step in signaling of cardiac hypertrophy. The molecular mechanisms by which CaMKII integrates with other pathways in the heart are incompletely understood. We hypothesize that CaMKII association with extracellular regulated kinase (ERK), promotes cardiac hypertrophy through ERK nuclear localization.In H9C2 cardiomyoblasts, the selective CaMKII peptide inhibitor AntCaNtide, its penetratin conjugated minimal inhibitory sequence analog tat-CN17β, and the MEK/ERK inhibitor UO126 all reduce phenylephrine (PE)-mediated ERK and CaMKII activation and their interaction. Moreover, AntCaNtide or tat-CN17β pretreatment prevented PE induced CaMKII and ERK nuclear accumulation in H9C2s and reduced the hypertrophy responses. To determine the role of CaMKII in cardiac hypertrophy in vivo, spontaneously hypertensive rats were subjected to intramyocardial injections of AntCaNtide or tat-CN17β. Left ventricular hypertrophy was evaluated weekly for 3 weeks by cardiac ultrasounds. We observed that the treatment with CaMKII inhibitors induced similar but significant reduction of cardiac size, left ventricular mass, and thickness of cardiac wall. The treatment with CaMKII inhibitors caused a significant reduction of CaMKII and ERK phosphorylation levels and their nuclear localization in the heart.These results indicate that CaMKII and ERK interact to promote activation in hypertrophy; the inhibition of CaMKII-ERK interaction offers a novel therapeutic approach to limit cardiac hypertrophy.
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- 2015
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27. Self-Assessment of Adherence to Medication: A Case Study in Campania Region Community-Dwelling Population
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Enrica Menditto, Francesca Guerriero, Valentina Orlando, Catherine Crola, Carolina Di Somma, Maddalena Illario, Donald E. Morisky, and Annamaria Colao
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Geriatrics ,RC952-954.6 - Abstract
Objectives. The aim of the study was to assess self-reported medication adherence measure in patients selected during a health education and health promotion focused event held in the Campania region. The study also assessed sociodemographic determinants of adherence. Methods. An interviewer assisted survey was conducted to assess adherence using the Italian version of the 8-item Morisky Medication Adherence Scale (MMAS-8). Participants older than 18 years were interviewed by pharmacists while waiting for free-medical checkup. Results. A total of 312 participants were interviewed during the Health Campus event. A total of 187 (59.9%) had low adherence to medications. Pearson’s bivariate correlation showed positive association between the MMAS-8 score and gender, educational level and smoking (P
- Published
- 2015
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28. Active and Healthy Ageing and Independent Living
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Maddalena Illario, Miriam Vollenbroek-Hutten, David William Molloy, Enrica Menditto, Guido Iaccarino, and Patrik Eklund
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Geriatrics ,RC952-954.6 - Published
- 2015
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29. A Community-Based, Technology-Supported Health Service for Detecting and Preventing Frailty among Older Adults: A Participatory Design Development Process
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Lex van Velsen, Maddalena Illario, Stephanie Jansen-Kosterink, Catherine Crola, Carolina Di Somma, Annamaria Colao, and Miriam Vollenbroek-Hutten
- Subjects
Geriatrics ,RC952-954.6 - Abstract
Frailty is a multifaceted condition that affects many older adults and marks decline on areas such as cognition, physical condition, and nutritional status. Frail individuals are at increased risk for the development of disability, dementia, and falls. There are hardly any health services that enable the identification of prefrail individuals and that focus on prevention of further functional decline. In this paper, we discuss the development of a community-based, technology-supported health service for detecting prefrailty and preventing frailty and further functional decline via participatory design with a wide range of stakeholders. The result is an innovative service model in which an online platform supports the integration of traditional services with novel, Information Communication Technology supported tools. This service is capable of supporting the different phases of screening and offers training services, by also integrating them with community-based services. The service model can be used as a basis for developing similar services within a wide range of healthcare systems. We present the service model, the general functioning of the technology platform, and the different ways in which screening for and prevention of frailty has been localized. Finally, we reflect on the added value of participatory design for creating such health services.
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- 2015
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30. Novel Therapeutic Targets in Metabolic Disorders: From the Bench to the Bedside
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Maddalena Illario, Carolina Di Somma, Guido Iaccarino, Pietro Campiglia, Uma Sankar, and Nunzia Montuori
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Technology ,Medicine ,Science - Published
- 2014
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31. A qualitative approach for the Health Technology Assessment of IT supported Type 2 Diabetes management tools.
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Giovanni Improta, Maddalena Illario, Vincenzo De Luca, Giovanni Annuzzi, Guido Iaccarino, and Maria Triassi
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- 2022
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32. Satisfaction, Self-management and Usability: Assessment of Two Novel IT Solutions for Type 2 Diabetes Patients' Empowerment.
- Author
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Vincenzo De Luca, Lutgarda Bozzetto, Clemente Giglio, Giovanni Tramontano, Carlos Juan Chiatti, Fotis Gonidis, Strahil Birov, Ozan Beyhan, Simon Robinson, Gorka Sánchez-Nanclares, Maria Del Pilar López Acuña, Adriano Fernandes, Maria Triassi, Giovanni Annuzzi, Guido Iaccarino, and Maddalena Illario
- Published
- 2021
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33. European Specifications for Value-based Pre-Commercial Procurement of Innovative ICT for Empowerment and Self-management of Diabetes Mellitus Patients.
- Author
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Vincenzo De Luca, Strahil Birov, Ozan Beyhan, Simon Robinson, Gorka Sánchez-Nanclares, Maria Del Pilar López Acuña, Adriano Fernandes, Reinhard Hammerschmidt, Giovanni Annuzzi, Guido Iaccarino, and Maddalena Illario
- Published
- 2019
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34. Developing a Digital Environment for the Management of Chronic Conditions: The ProEmpower Experience of a Horizon 2020 PCP for Type 2 Diabetes.
- Author
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Vincenzo De Luca, Strahil Birov, Ozan Beyhan, Simon Robinson, Gorka Sánchez-Nanclares, Maria Del Pilar López Acuña, Adriano Fernandes, Reinhard Hammerschmidt, Giovanni Tramontano, Roberta Patalano, Guglielmo Toscano, Giovanni Annuzzi, Guido Iaccarino, Maria Triassi, and Maddalena Illario
- Published
- 2019
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35. Healthcare Recommendations from the Personalised ICT Supported Service for Independent Living and Active Ageing (PERSSILAA) Study.
- Author
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Rónán O'Caoimh, D. William Molloy, Carol Fitzgerald, Lex van Velsen, Miriam Cabrita, Mohammad Hossein Nassabi, Frederiek de Vette, Marit Dekker-van Weering, Stephanie Jansen-Kosterink, Wander Kenter, Sanne Frazer, Amélia P. Rauter, Maria Antónia Amaral Turkman, Marília Antunes, Feridun Turkman, Marta Sousa Silva, Alice Martins, Helena S. Costa, Tânia Gonçalves Albuquerque, António E. N. Ferreira, Mario Scherillo, Vincenzo De Luca, Maddalena Illario, Alejandro García-Rudolph, Rocio Sanchez-Carrion, Javier Solana Sánchez, Enrique J. Gómez Aguilera, Hermie Hermens, and Miriam M. R. Vollenbroek-Hutten
- Published
- 2017
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36. ICT-Supported Interventions Targeting Pre-frailty: Healthcare Recommendations from the Personalised ICT Supported Service for Independent Living and Active Ageing (PERSSILAA) Study.
- Author
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Rónán O'Caoimh, D. William Molloy, Carol Fitzgerald, Lex van Velsen, Miriam Cabrita, Mohammad Hossein Nassabi, Frederiek de Vette, Marit Dekker-van Weering, Stephanie Jansen-Kosterink, Wander Kenter, Sanne Frazer, Amélia P. Rauter, Maria Antónia Amaral Turkman, Marília Antunes, Feridun Turkman, Marta Sousa Silva, Alice Martins, Helena S. Costa, Tânia Gonçalves Albuquerque, António E. N. Ferreira, Mario Scherillo, Vincenzo De Luca, Pasquale Abete, Annamaria Colao, Alejandro García-Rudolph, Rocio Sanchez-Carrion, Javier Solana Sánchez, Enrique J. Gómez Aguilera, Maddalena Illario, Hermie Hermens, and Miriam M. R. Vollenbroek-Hutten
- Published
- 2017
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37. Development and validation of combined symptom-medication scores for allergic rhinitis*
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Bernardo Sousa‐Pinto, Luís Filipe Azevedo, Marek Jutel, Ioana Agache, G. Walter Canonica, Wienczyslawa Czarlewski, Nikolaos G. Papadopoulos, Karl‐Christian Bergmann, Philippe Devillier, Daniel Laune, Ludger Klimek, Aram Anto, Josep M. Anto, Patrik Eklund, Rute Almeida, Anna Bedbrook, Sinthia Bosnic‐Anticevich, Helen A. Brough, Luisa Brussino, Victoria Cardona, Thomas Casale, Lorenzo Cecchi, Denis Charpin, Tomás Chivato, Elisio M. Costa, Alvaro A. Cruz, Stephanie Dramburg, Stephen R. Durham, Giulia De Feo, Roy Gerth van Wijk, Wystke J. Fokkens, Bilun Gemicioglu, Tari Haahtela, Maddalena Illario, Juan Carlos Ivancevich, Violeta Kvedariene, Piotr Kuna, Désirée E. Larenas‐Linnemann, Michael Makris, Eve Mathieu‐Dupas, Erik Melén, Mario Morais‐Almeida, Ralph Mösges, Joaquim Mullol, Kari C. Nadeau, Nhân Pham‐Thi, Robyn O’Hehir, Frederico S. Regateiro, Sietze Reitsma, Boleslaw Samolinski, Aziz Sheikh, Cristiana Stellato, Ana Todo‐Bom, Peter Valentin Tomazic, Sanna Toppila‐Salmi, Antonio Valero, Arunas Valiulis, Maria Teresa Ventura, Dana Wallace, Susan Waserman, Arzu Yorgancioglu, Govert De Vries, Michiel van Eerd, Petra Zieglmayer, Torsten Zuberbier, Oliver Pfaar, João Almeida Fonseca, Jean Bousquet, Internal Medicine, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, University of Helsinki, Ear, Nose and Throat, AII - Inflammatory diseases, Publica, Sousa-Pinto, B., Azevedo, L. F., Jutel, M., Agache, I., Canonica, G. W., Czarlewski, W., Papadopoulos, N. G., Bergmann, K. -C., Devillier, P., Laune, D., Klimek, L., Anto, A., Anto, J. M., Eklund, P., Almeida, R., Bedbrook, A., Bosnic-Anticevich, S., Brough, H. A., Brussino, L., Cardona, V., Casale, T., Cecchi, L., Charpin, D., Chivato, T., Costa, E. M., Cruz, A. A., Dramburg, S., Durham, S. R., De Feo, G., Gerth van Wijk, R., Fokkens, W. J., Gemicioglu, B., Haahtela, T., Illario, M., Ivancevich, J. C., Kvedariene, V., Kuna, P., Larenas-Linnemann, D. E., Makris, M., Mathieu-Dupas, E., Melen, E., Morais-Almeida, M., Mosges, R., Mullol, J., Nadeau, K. C., Pham-Thi, N., O'Hehir, R., Regateiro, F. S., Reitsma, S., Samolinski, B., Sheikh, A., Stellato, Cristiana, Todo-Bom, A., Tomazic, P. V., Toppila-Salmi, S., Valero, A., Valiulis, A., Ventura, M. T., Wallace, D., Waserman, S., Yorgancioglu, A., De Vries, G., van Eerd, M., Zieglmayer, P., Zuberbier, T., Pfaar, O., Almeida Fonseca, J., and Bousquet, J.
- Subjects
Work ,medication score ,quality-of-life ,rhinitis ,symptom score ,work ,Respiratory Medicine and Allergy ,Immunology ,QUESTIONNAIRE ,RESPONSIVENESS ,Humans ,Immunology and Allergy ,IMMUNOTHERAPY ,VALIDITY ,Lungmedicin och allergi ,Rhinitis ,Medication score ,EQ-5D ,Reproducibility of Results ,IMPAIRMENT ,Rhinitis, Allergic ,WORK PRODUCTIVITY ,Symptom score ,rhiniti ,TRIALS ,3121 General medicine, internal medicine and other clinical medicine ,RELIABILITY ,Quality of Life ,ASTHMA ,Quality-of-life ,600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit - Abstract
Background: Validated combined symptom-medication scores (CSMSs) are needed to investigate the effects of allergic rhinitis treatments. This study aimed to use real-life data from the MASK-air® app to generate and validate hypothesis- and data-driven CSMSs. Methods: We used MASK-air® data to assess the concurrent validity, test-retest reliability and responsiveness of one hypothesis-driven CSMS (modified CSMS: mCSMS), one mixed hypothesis- and data-driven score (mixed score), and several data-driven CSMSs. The latter were generated with MASK-air® data following cluster analysis and regression models or factor analysis. These CSMSs were compared with scales measuring (i) the impact of rhinitis on work productivity (visual analogue scale [VAS] of work of MASK-air®, and Work Productivity and Activity Impairment: Allergy Specific [WPAI-AS]), (ii) quality-of-life (EQ-5D VAS) and (iii) control of allergic diseases (Control of Allergic Rhinitis and Asthma Test [CARAT]). Results: We assessed 317,176 days of MASK-air® use from 17,780 users aged 16-90 years, in 25 countries. The mCSMS and the factor analyses-based CSMSs displayed poorer validity and responsiveness compared to the remaining CSMSs. The latter displayed moderate-to-strong correlations with the tested comparators, high test-retest reliability and moderate-to-large responsiveness. Among data-driven CSMSs, a better performance was observed for cluster analyses-based CSMSs. High accuracy (capacity of discriminating different levels of rhinitis control) was observed for the latter (AUC-ROC = 0.904) and for the mixed CSMS (AUC-ROC = 0.820). Conclusion: The mixed CSMS and the cluster-based CSMSs presented medium-high validity, reliability and accuracy, rendering them as candidates for primary endpoints in future rhinitis trials.
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- 2022
38. List of contributors
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Margarida Abrantes, Raquel Alves, Sharath Anugula, Veronica Aran, Lina Badimon, Jorge N. Barreto, Grzegorz Bartosz, Fernanda Borges, Consuelo Borrás, Maria Filomena Botelho, Jean Bousquet, António M.D. Brehm, Gerly A.C. Brito, Daan Bultje, Ana Cristina Cabral, André Caetano, Helena Canhão, Isabel Marques Carreira, Ana Maria Carriazo, Cristina Carvalho, Eugenia Carvalho, Margarida Castel-Branco, Yaohua Chen, João M. Coelho-Filho, Vera Constâncio, António Correia e Silva, Deiziane V.S. Costa, Elísio Costa, Inês Costa, Teresa Cunha-Oliveira, Paulo de Carvalho, Vicenzo De Luca, Edoardo R. de Natale, Jorge Dias, Ronaldo P. Dias, Ana I. Duarte, John Farrel, Fernando Fernandez-Llimos, Lino Ferreira, Luigi Ferrucci, Isabel Vitoria Figueiredo, Jamie K. Ford, Claudio Franceschi, Alex A. Freitas, Maja Furlan de Brito, Karla C. Giacomin, Henrique Girao, Ilias Gkikas, Bárbara Gomes, Rodrigo M. Gomes, Ana Cristina Gonçalves, Peter Goulden, Marcus Grant, Luís F. Grilo, Nick Guldemond, Jorge Henriques, Manoela Heringer, Maddalena Illario, Carmen Jerónimo, John G. Jones, Joana Jorge, Yaschar Kabiri, Agnieszka Karkucinska-Wieckowska, George Kelly, James L. Kirkland, Kristina Kitaeva, Andrey Kiyasov, Viktor I. Korolchuk, Mafalda Laranjo, Thomas J. LaRocca, Marta Lavrador, Magdalena Lebiedzinska-Arciszewska, Zhiquan Li, Yuezhong Liu, Alexandre Lourenço, Lina Ma, João O. Malva, Christopher R. Martens, Cristina Mas-Bargues, Paulo Matafome, Joana Barbosa Melo, Maria L. Lima Mendonça, Athanasios Metaxakis, Lefkos T. Middleton, Paula I. Moreira, Judite M. Nascimento, Vivaldo M. Neto, Paulo J. Oliveira, Alessandro Ori, Reinaldo B. Oriá, Susan E. Ozanne, Miguel Padeiro, Teresa Padro, Carlos M. Palmeira, Yiming Pan, Simão Paredes, João F. Passos, Edith Pereira, Francisco B. Pereira, Susana P. Pereira, Paolo Pinton, Joana F. Pires, Salomé Pires, M. Cristina Polidori, Marios Politis, Nuno Raimundo, João Ramalho-Santos, Lene Juel Rasmussen, Fernando J. Regateiro, Dario D. Reis, Caio Ribeiro, Ilda Patrícia Ribeiro, Teresa M. Ribeiro-Rodrigues, Albert Rizvanov, Teresa Rocha, Susanne Röhr, Anabela P. Rolo, Aurora Román-Domínguez, Roman Romero-Ortuno, Manuel Santos Rosa, Catrin Rutland, Izabela Sadowska-Bartosz, Paula Santana, Deolinda Santinha, Marcos Santos, Ana Bela Sarmento Ribeiro, Deisa S.R.C. Semedo, João Sequeira, Felipe Sierra, Maria Natalina L. Silva, Rafael Solana, Valeriya Solovyeva, Hélder Spínola, Renata S. Tavares, Nektarios Tavernarakis, Tamar Tchkonia, Yin-Leng Theng, Vicente Traver-Salcedo, Chi Udeh-Momoh, Rakhi Verma, Stella Victorelli, Andreia Vilaça, Gemma Vilahur, José Viña, Thomas von Zglinicki, Devin Wahl, Berenice Maria Werle, Mariusz R. Wieckowski, Heather Wilson, Erin O. Wissler Gerdes, Lucyna A. Wozniak, Barbara Zavan, Yi Zhu, and Hans Zischka
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- 2023
39. Digital Health Service for Identification of Frailty Risk Factors in Community-Dwelling Older Adults: The SUNFRAIL+ Study Protocol
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Vincenzo De Luca, Grazia Daniela Femminella, Lisa Leonardini, Lola Patumi, Ernesto Palummeri, Isabella Roba, Walter Aronni, Stefano Toccoli, Simona Sforzin, Fortunata Denisi, Anna Maddalena Basso, Manuela Ruatta, Paola Obbia, Alessio Rizzo, Moira Borgioli, Claudio Eccher, Riccardo Farina, Diego Conforti, Lorenzo Mercurio, Elena Salvatore, Maurizio Gentile, Marialuisa Bocchino, Alessandro Sanduzzi Zamparelli, Giulio Viceconte, Ivan Gentile, Carlo Ruosi, Nicola Ferrara, Gabriella Fabbrocini, Annamaria Colao, Maria Triassi, Guido Iaccarino, Giuseppe Liotta, Maddalena Illario, De Luca, Vincenzo, Daniela Femminella Lisa Leonardini, Grazia, Patumi, Lola, Palummeri, Ernesto, Roba, Isabella, Aronni, Walter, Toccoli, Stefano, Sforzin, Simona, Denisi, Fortunata, Maddalena Basso, Anna, Ruatta, Manuela, Obbia, Paola, Rizzo, Alessio, Borgioli, Moira, Eccher, Claudio, Farina, Riccardo, Conforti, Diego, Mercurio, Lorenzo, Salvatore, Elena, Gentile, Maurizio, Bocchino, Marialuisa, SANDUZZI ZAMPARELLI, Alessandro, Viceconte Ivan Gentile, Giulio, Ruosi, Carlo, Ferrara, Nicola, Fabbrocini, Gabriella, Colao Maria Triassi Guido Iaccarino, Annamaria, and Liotta andMaddalena Illario, Giuseppe
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pre-frailty ,nursing ,Health, Toxicology and Mutagenesis ,active and healthy aging ,community-dwelling older adult ,Public Health, Environmental and Occupational Health ,frailty ,bio–psycho–social domain ,frailty risk factor ,study protocol - Abstract
This article reports the study protocol of a nationwide multicentric study in seven Italian regions aimed at assessing the effectiveness of a digitally supported approach for the early screening of frailty risk factors in community-dwelling older adults. SUNFRAIL+ is a prospective observational cohort study aimed at carrying out a multidimensional assessment of community-dwelling older adults through an IT platform, which allows to connect the items of the SUNFRAIL frailty assessment tool with a cascading multidimensional in-depth assessment of the bio–psycho–social domains of frailty. Seven centers in seven Italian regions will administer the SUNFRAIL questionnaire to 100 older adults. According to the answers provided by older adults, they will be subjected to one or more validated in-depth scale tests in order to perform further diagnostic or dimensional evaluations. The study aims to contribute to the implementation and validation of a multiprofessional and multistakeholder service model for the screening of frailty in community-dwelling older adult population.
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- 2023
40. Flagship initiatives for healthy living and active aging in Europe: the European Innovation Partnership on Active and Healthy Ageing and the Reference Sites
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João O. Malva, Daan Bultje, Vicente Traver-Salcedo, Ana Maria Carriazo, Maddalena Illario, Vicenzo De Luca, Lucyna A. Wozniak, Jean Bousquet, Nick Guldemond, Inês Costa, Helena Canhão, Elísio Costa, and John Farrel
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- 2023
41. Smart and inclusive environments for all - SHAFE explained
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Carina Dantas, Luiza Spiru, Willeke H. van Staalduinen, and Maddalena Illario
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Coronavirus disease 2019 (COVID-19) ,business.industry ,media_common.quotation_subject ,Policy initiatives ,Public relations ,Work (electrical) ,Cultural diversity ,Political science ,Health care ,European commission ,business ,Duty ,media_common ,Meaning (linguistics) - Abstract
The meaning and notion of Smart Healthy Age-Friendly Environments (SHAFE) as a holistic approach that promotes the alignment of policies and strategies across domains is a unique roadmap for the implementation of inclusive communities in and across Europe, improving and supporting independent life throughout its entire course, regardless of age, gender, disabilities, cultural differences and personal choices. When we acknowledge the serious challenges especially those related to demographic change and the COVID-19 pandemic, it is not possible anymore to still work in silos or to keep positions for individual interest. Before any other role, we all are citizens and we have a duty as researchers, academics, policy makers, practitioners, industry and business to work together for a better world. In this paper, the SHAFE concept is explained and an overview of running initiatives is presented. Also the alignment within current policy initiatives of the European Commission is explored and the recognition of SHAFE implemented through NET4Age-Friendly addressed.
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- 2021
42. eHealth platforms to promote autonomous life and active aging: A scoping review
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Vincenzo De Luca, Nina Jøranson, Elaine Santana, Minna Zechner, Maddalena Illario, Joao Luis Alves Apostolo, Ricardo Loureiro, Nilufer Korkmaz Yaylagul, Filipa Margarida Duque, Joana Bernardo, Carina Dantas, Rosa Silva, Filipa Ventura, Willeke Van Staalduinen, Bernardo, J., Apostolo, J., Loureiro, R., Santana, E., Yaylagul, N. K., Dantas, C., Ventura, F., Duque, F. M., Joranson, N., Zechner, M., Staalduinen, W. V., De Luca, V., Illario, M., and Silva, R.
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Europe ,Aging ,healthy aging ,SHAFE ,personal autonomy ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Humans ,eHealth strategies ,Telemedicine ,eHealth strategie ,Aged - Abstract
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). New technologies, namely eHealth platforms, are being used more than ever before. These platforms enable older people to have a more independent lifestyle, enhance their participation, and improve their well-being. Information and communication technologies are expected to be linked to the triad of aging, social inclusion, and active participation, which is in line with the implementation of Smart Healthy and Age-Friendly Environments. This scoping review aimed to map eHealth platforms designed to promote autonomous life and active aging. The Joanna Briggs Institute methodology and the PRISMA-ScR checklist were used. A search was conducted on MEDLINE (via PubMed), CINAHL Complete (via EBSCOhost), Scopus, Cochrane Database of Systematic Reviews (via EBSCOhost), SciELO, DART-Europe, CAPES, and MedNar databases. Fourteen studies were included. This scoping review synthesized information on eHealth platforms designed to promote active living, their domains of intervention, and the outcomes assessed in those studies that have implemented and evaluated these eHealth platforms.
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- 2022
43. Preventing and managing falls: an international online survey
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Carolin Herzog, Giovanni Tramontano, Regina Roller-Wirnsberger, Maddalena Illario, Marie Curran, and Anne Hendry
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Health (social science) ,Sociology and Political Science ,Health Policy - Abstract
Introduction: Rates of falls increase with ageing and age-related biological and functional changes. Most falls in later life occur as a result of a complex interaction between multiple intrinsic and environmental risk factors. Falls and falls-related injuries are major public health problems that often require healthcare intervention and rehabilitation (1) and recurrent falls are a frequent trigger for older people and their families seeking long term institutional care. Therefore, the prevention and management of falls has substantial relevance for integrated care systems. This study sought to obtain international insight into the implementation of pathways or programs addressing balance, mobility and/or falls prevention in primary care or community services.Methods: A survey template was created to include the key elements detected during a literature review conducted by MUG. The template included questions on screening, assessment, intervention components, target group, professionals involved and tools used for assessment and/or monitoring experience and outcomes. Members of IFIC’s international Special Interest Groups(SIGs) on Ageing and Frailty, Intermediate Care were invited to complete an online EU Survey tool available from 01.06-01.08.2021. Responses were analysed by two researchers and results considered by the co-authors in an online focus group. Results: 16 people from 11 countries completed the online survey. 9/16 reported fully implemented falls programs or care pathways in their region or country: UK (3), Ireland (1), Spain (1), Indonesia (1), Peru (1), Australia (1) and Northwest USA (1). Seven examples are focused on older citizens but one is for older people with frailty & neurodegenerative diseases (New South Wales, Australia) and one is a pathway for patients in Indonesia, independent of disease and/or age limits. Professional disciplines involved differed across countries but allied health professionals and nurses were commonly involved. Family physicians were involved in only the examples from the USA and Indonesia. Specialist physicians in geriatric medicine were involved in five of the examples. Five programs involved pharmacists to advise on medication and two programs involved trained volunteers. Public/patient information and education was the most common intervention and was the sole intervention in the Spanish example reported. Three of the nine programs did not routinely evaluate patient experience or functional outcomes. Only three pathways enabled patient level data to flow through the electronic care record. Conclusion: The international survey offers initial insight into implemented pathways and programs for the prevention and management of falls in primary care and community settings in different countries. It paves the way for a more targeted survey and Delphi consensus process on the design and benchmarking of integrated services to address the challenge of falls in ageing societies.Implications: The evidence-based examples in the survey highlight processes and interventions that are readily transferable and where adoption will facilitate standardization and improved quality of care. The next phase aims to agree key components and performance indicators to allow future benchmarking and system-based evidence generation on prevention and management of falls in the community.References(1) World Health Organization. WHO global report on falls prevention in older age. World Health Organization; 2008.
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- 2022
44. An activity-based costing approach for detecting inefficiencies of healthcare processes.
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Lorella Cannavacciuolo, Maddalena Illario, Adelaide Ippolito, and Cristina Ponsiglione
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- 2015
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45. Proposal for innovative and integrated approaches to the unmet needs of patients with irritable bowel syndrome. Preliminary Vigour report
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Maurizio, Gentile, Vincenzo, De Luca, Roberta, Patalano, Daniela, Laudisio, Giovanni, Tramontano, Sonja, Lindner-Rabl, Lorenzo, Mercurio, Elena, Salvatore, John, Farrell, Regina, Roller-Wirnsberger, Lutz, Kubitschke, Maria, Triassi, Annamaria, Colao, and Maddalena, Illario
- Abstract
Irritable bowel syndrome (IBS) is a common multifactorial condition that affects the large intestine and is characterized by chronic and relapsing abdominal pain and altered bowel habit. IBS is due to a combination of genetic, environmental and dietary factors. It's usually a lifelong problem very frustrating to live with and can have a big impact on quality of life, as single-agent therapy rarely relieves bothersome symptoms for all patients. The objective of this study was to analyze the approaches and solutions that address the social and health unmet needs of patients with IBS. A qualitative approach was adopted in the current study to identify and specify key digital solution and high impact user scenarios applied to IBS patients, through an adaptation of the "Blueprint on Digital Transformation in Health and Care in an Ageing Society" persona methodology. A Survey was administered to a group of patients in anonymous form. The theoretical elaboration IBS personas was developed through an interdisciplinary Focus Group, which also mapped the pathway for the patient's management. Three main needs were identified to be met to improve IBS patient's lifestyle: access to psychological support, mHealth solutions supporting diet and adapted physical activity, and homebased digital health support. mHealth intervention has been identified for diet adherence, physical exercise and psychological well-being. The process has been mapped and adapted to integrate the new solutions into the care pathway. Further research is needed to evaluate how mHealth services enable IBS patients to manage their conditions and improve their quality of life. KEY WORDS: Digital Health, Irritable bowel syndrome, mHealth, Nutrition, Physical activity, Psychological support.La sindrome dell’intestino irritabile (IBS) è una condizione multifattoriale comune che colpisce l’intestino crasso ed è caratterizzata da dolore addominale cronico e recidivante e alterazione delle abitudini intestinali. L’IBS è dovuta a una combinazione di fattori genetici, ambientali e dietetici. Di solito è un problema che permane per tutta la vita, molto frustrante per conviverci e può avere un grande impatto negativo sulla qualità della vita, poiché la terapia con un solo farmaco raramente allevia i sintomi fastidiosi per tutti i pazienti. L’obiettivo di questo studio era di analizzare gli approcci e le soluzioni che affrontano i bisogni sociali e sanitari insoddisfatti dei pazienti con IBS. Nel presente studio è stato adottato un approccio qualitativo per identificare e specificare la soluzione digitale chiave e gli scenari utente ad alto impatto applicati ai pazienti con IBS, attraverso un adattamento al singolo della metodologia “Blueprint on Digital Transformation in Health and Care in an Aging Society”. Un sondaggio è stato somministrato a un gruppo di pazienti in forma anonima. L’elaborazione teorica IBS personale è stata sviluppata attraverso un Focus Group interdisciplinare, che ha anche tracciato il percorso per la gestione del paziente. Sono state identificate tre esigenze principali da soddisfare per migliorare lo stile di vita dei pazienti affetti da IBS: accesso al supporto psicologico, soluzioni di mHealth a supporto della dieta e dell’attività fisica adattata e supporto sanitario digitale domiciliare. L’intervento mHealth è stato identificato per l’aderenza alla dieta, l’esercizio fisico e il benessere psicologico. Il processo è stato mappato e adattato per integrare le nuove soluzioni nel percorso assistenziale. Sono necessarie ulteriori ricerche per valutare in che modo i servizi di mHealth consentano ai pazienti con IBS di gestire le loro condizioni e migliorare la loro qualità di vita.
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- 2022
46. Calcium/calmodulin-dependent kinases can regulate the TSH expression in the rat pituitary
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Donatella Cimini, Maddalena Illario, Giovanna Giuseppina Altobelli, Daniela Sorriento, S. Van Noorden, Vincenzo Cimini, Altobelli, G. G., Van Noorden, S., Cimini, D., Illario, M., Sorriento, D., Cimini, V., Altobelli, Gg, Van Noorden, S, Cimini, D, Illario, M, Sorriento, D, and Cimini, V
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Ca signaling ,Benzylamines ,endocrine system ,endocrine system diseases ,Calmodulin ,Endocrinology, Diabetes and Metabolism ,Rat pituitary ,Thyrotropin ,030209 endocrinology & metabolism ,CREB ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Anterior pituitary ,Ca2+/calmodulin-dependent protein kinase ,Gene expression ,medicine ,Animals ,Calcium Signaling ,Phosphorylation ,Cyclic AMP Response Element-Binding Protein ,Protein Kinase Inhibitors ,Thyrotropin-Releasing Hormone ,CAMK ,Cells, Cultured ,Sulfonamides ,biology ,TSH ,Kinase ,Chemistry ,Gene Expression Profiling ,Immunochemistry ,CaM kinase ,Rats ,Cell biology ,medicine.anatomical_structure ,Gene Expression Regulation ,Pituitary Gland ,030220 oncology & carcinogenesis ,Calcium-Calmodulin-Dependent Protein Kinases ,biology.protein ,hormones, hormone substitutes, and hormone antagonists ,Signal Transduction - Abstract
PURPOSE: The endocrine secretion of TSH is a finely orchestrated process controlled by the thyrotropin-releasing hormone (TRH). Its homeostasis and signaling rely on many calcium-binding proteins belonging to the "EF-hand" protein family. The Ca2+/calmodulin (CaM) complex is associated with Ca2+/CaM-dependent kinases (Ca2+/CaMK). We have investigated Ca2+/CaMK expression and regulation in the rat pituitary. METHODS: The expression of CaMKII and CaMKIV in rat anterior pituitary cells was shown by immunohistochemistry. Cultured anterior pituitary cells were stimulated by TRH in the presence and absence of KN93, the pharmacological inhibitor of CaMKII and CaMKIV. Western blotting was then used to measure the expression of these kinases and of the cAMP response element-binding protein (CREB). TSH production was measured by RIA after time-dependent stimulation with TRH. Cells were infected with a lentiviral construct coding for CaMKIV followed by measurement of CREB phosphorylation and TSH. RESULTS: Our study shows that two CaM kinases, CaMKII and CaMKII, are expressed in rat pituitary cells and their phosphorylation in response to TRH occurs at different time points, with CaMKIV being activated earlier than CaMKII. TRH induces CREB phosphorylation through the activity of both CaMKII and CaMKIV. The activation of CREB increases TSH gene expression. CaMKIV induces CREB phosphorylation while its dominant negative and KN93 exert the opposite effects. CONCLUSION: Our data indicate that the expression of Ca2+/CaMK in rat anterior pituitary are correlated to the role of CREB in the genetic regulation of TSH, and that TRH stimulation activates CaMKIV, which in turn phosphorylates CREB. This phosphorylation is linked to the production of thyrotropin.
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- 2021
47. The role of health determinants in the influenza vaccination uptake among older adults (65+): a scope review
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Sonja Lindner, Lea Kolosovski, Holger Flick, Peter Dovjak, Regina Roller-Wirnsberger, Chariklia Tziraki, Maddalena Illario, Elisabeth Platzer, Roller-Wirnsberger, R., Lindner, S., Kolosovski, L., Platzer, E., Dovjak, P., Flick, H., Tziraki, C., and Illario, M.
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Aging ,Influenza vaccine ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Psychological intervention ,Context (language use) ,Review ,Health determinant ,Seasonal influenza ,03 medical and health sciences ,0302 clinical medicine ,Environmental health ,Pandemic ,Influenza, Human ,Medicine ,Humans ,030212 general & internal medicine ,Older adult ,Aged ,0303 health sciences ,Scope (project management) ,030306 microbiology ,business.industry ,SARS-CoV-2 ,Vaccination ,COVID-19 ,Vaccination hesitancy ,Vaccination uptake ,Influenza vaccination ,Ageing ,Influenza Vaccines ,Older adults ,Health determinants ,Geriatrics and Gerontology ,Influenza Vaccine ,business ,Human - Abstract
Background Although the burden of influenza infection is the highest in older adults, vaccination coverage remains low, despite this age group being more vulnerable than others. Aims Given the current pandemic of SARS-CoV-2, it was the aim of this scope review to update knowledge on factors affecting seasonal influenza vaccine uptake among older adults to strengthen prevention approaches in the context of an overall burden of infectious diseases. Methods We searched bibliographic databases from 2012 to 2019. All studies reviewed one or more social determinant of health listed by WHO, or factors affecting the decision-making process whether to accept influenza vaccine or not. Results Overall, 44 studies were included, 41 determinants were extracted and summarized into six categories. Older age and constitutional factors including multiple chronic diseases as well as preventive lifestyle and frequent routine healthcare utilization positively affected vaccination uptake (VU). Living and working conditions are also researched determinants of influenza vaccine uptake. A small number of studies explored the role of social inclusion and system-based interventions. Discussion and conclusions This scope review provides a comprehensive overview on factors affecting seasonal influenza vaccination uptake among older citizens. The review also clearly shows gaps for evidence on system-based level or political strategies to improve vaccination uptake.
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- 2021
48. Exploratory Factor Analysis (EFA) of the Short Functional Geriatric Evaluation (SFGE) to Assess the Multidimensionality of Frailty in Community-Dwelling Older Adults
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Giuseppe Liotta, Grazia Lorusso, Olga Madaro, Valeria Formosa, Leonardo Emberti Gialloreti, Clara Donnoli, Fabio Riccardi, Stefano Orlando, Paola Scarcella, Joao Apostolo, Rosa Silva, Carina Dantas, Willeke van Staalduinen, Vincenzo De Luca, Maddalena Illario, Susanna Gentili, and Leonardo Palombi
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multidimensional evaluation ,SFGE ,EFA ,Health, Toxicology and Mutagenesis ,Settore MED/42 ,Public Health, Environmental and Occupational Health ,biopsychosocial frailty ,assessment tool ,frailty ,older adults - Abstract
The Short Functional Geriatric Evaluation (SFGE) is a multidimensional and short questionnaire to assess biopsychosocial frailty in older adults. This paper aims to clarify the latent factors of SFGE. Data were collected from January 2016 to December 2020 from 8800 community-dwelling older adults participating in the “Long Live the Elderly!” program. Social operators administered the questionnaire through phone calls. Exploratory factor analysis (EFA) was carried out to identify the quality of the structure of the SFGE. Principal component analysis was also performed. According to the SFGE score, 37.7% of our sample comprised robust, 24.0% prefrail, 29.3% frail, and 9.0% very frail individuals. Using the EFA, we identified three main factors: psychophysical frailty, the need for social and economic support, and the lack of social relationships. The Kaiser–Meyer–Olkin measure of sampling adequacy was 0.792, and Bartlett’s test of sphericity had a statistically significant result (p-value < 0.001). The three constructs that emerged explain the multidimensionality of biopsychosocial frailty. The SFGE score, 40% of which is social questions, underlines the crucial relevance of the social domain in determining the risk of adverse health outcomes in community-dwelling older adults.
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- 2023
49. The Frailty of the Invincible
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L Noronha Ferreira, M Sambati, Maddalena Illario, Ana Maria Teixeira, F Lanata, Donatella Tramontano, V Zavagli, S. Pais, J. Farrell, Illario, M, Zavagli, V, Ferreira, L Noronha, Sambati, M, Teixeira, A, Lanata, F, Pais, S, Farrell, J, and Tramontano, D
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medicine.medical_specialty ,Technological revolution ,reconstruction ,media_common.quotation_subject ,Well-being ,Globalization ,Economic inequality ,inequalitie ,inequalities ,well-being ,Political science ,Development economics ,Health care ,medicine ,General Environmental Science ,media_common ,business.industry ,Public health ,Articles ,Democracy ,Preparedness ,Economic evaluation ,General Earth and Planetary Sciences ,Inequalities ,Reconstruction ,business - Abstract
The COVID-19 pandemic has unveiled the frailty of our societies from too many points of view to look away. We need to understand why we were all caught unprepared. On the one hand, we have all short memories. As we forget too quickly, we were unable to recognize key factors influencing response and preparedness to public health threats. For many years, economic evaluation pushed governments all over the world to cut resources for public health systems, with COVID-19 pandemic the question arises: do we spend too much or too little on health care? What is the right amount to spend on health? Moreover, in many countries, the privatisation, or semi-privatisation, of healthcare may give rise to inequitable access to health care for everyone. Although COVID-19 is very “democratic”, its consequences aren’t. According to OECD, income inequality in OECD countries is at its highest level for the past half century. Three main causes have been recognized, technological revolution, globalization, and “financialisation”. In this scenario, lockdown measures adopted to save lives are showing dramatic economic consequences. To address post COVID-19 reconstruction we need to go beyond GDP. As an economic measure this has many shortcomings in describing the real well-being of a country, and since what we measure affects what we do, new paradigms will have to guide the post COVID-19 reconstruction strategies, as the fate of countries and their citizens is at stake. info:eu-repo/semantics/publishedVersion
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- 2020
50. Relational quality and improvement of Life Skills (No technical Skills)
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Ciro Verdoliva, Maria Corvino, Michele Ciarfera, Sara Diamare, Arianna Glorioso, Claudia Ruocco, Maddalena Illario, Giancarlo Pocetta, Verdoliva, Ciro, Corvino, Maria, Ciarfera, Michele, Diamare, Sara, Glorioso, Arianna, Ruocco, Claudia, Illario, Maddalena, and Pocetta, Giancarlo
- Subjects
General Medicine - Abstract
The provision of health services implicitly involves an emotional load linked to the specific task / service, which, if extended for long periods of time, falls on the operators, placing them in a burn-out risk. Various theories and empirical studies (Mayo, 1933; Maslow, 1943; Herzberg, 1959; Vroom, 1964; Alderfer, 1969; Fontana, 1997; McClellant, 1985) reveal how "motivated" work performances generate a sense of personal fulfillment which can be translated into a positive result for performance in general. Therefore, Healthcare Companies must improve the quality of assistance provided by the operators through motivational, wellness and health promotion’s activities for the staff. In this study we want to demonstrate that psycho-body empowerment © training supported by group psychodynamic proposals with expressive techniques, allows the acquisition of the necessary life skills to support the health worker's perception of well-being. These activities are aimed at developing a healthy and safe work environment, which also considers the psychological, social and relational implications of the organizational context related to the gender gap. In the present study, we wanted to explore whether the experiential methodology presented here, aimed at psycho- corporeal awareness in the relationship with the other, could support a path of psychological well-being perceived by the operators, as imagined and measured by Carol Ryff (1989). In particular, an attempt was made to highlight the difference in the acquisition of skills between male and female health workers, showing that some of them can be more easily acquired by one gender than another. The action research in this presented study, adapted in web mode in compliance with the safety standards imposed by the COVID-19 pandemic, has been supported by e-learning technologies and the results of this further study will be the subject of subsequent publication.
- Published
- 2022
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