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777 results on '"Madan V"'

1. Automated Cricket Commentary Generation for Videos

Author

Shashank Yadav, K., Lohith, V., Sachin, M. S., Patil, Madan V., Narayan, Surabhi, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Kaur, Harkeerat, editor, Jakhetiya, Vinit, editor, Goyal, Puneet, editor, Khanna, Pritee, editor, Raman, Balasubramanian, editor, and Kumar, Sanjeev, editor

Published
2024
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4. Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD)

Author

Sun, Q-Y, Ding, L-W, Tan, K-T, Chien, W, Mayakonda, A, Lin, D-C, Loh, X-Y, Xiao, J-F, Meggendorfer, M, Alpermann, T, Garg, M, Lim, S-L, Madan, V, Hattori, N, Nagata, Y, Miyano, S, Yeoh, AEJ, Hou, H-A, Jiang, Y-Y, Takao, S, Liu, L-Z, Tan, S-Z, Lill, M, Hayashi, M, Kinoshita, A, Kantarjian, HM, Kornblau, SM, Ogawa, S, Haferlach, T, Yang, H, and Koeffler, HP

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Hematology, Cancer, Childhood Leukemia, Pediatric, Genetics, Pediatric Cancer, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Cell Proliferation, Clone Cells, Exome, Histone-Lysine N-Methyltransferase, Humans, Leukemia, Myeloid, Acute, Mutation, Mutation Rate, Myeloid-Lymphoid Leukemia Protein, Nucleophosmin, Tandem Repeat Sequences, Time Factors, Clinical Sciences, Immunology, Cardiovascular medicine and haematology, Clinical sciences, Oncology and carcinogenesis
Abstract

Partial tandem duplication of MLL (MLL-PTD) characterizes acute myeloid leukemia (AML) patients often with a poor prognosis. To understand the order of occurrence of MLL-PTD in relation to other major AML mutations and to identify novel mutations that may be present in this unique AML molecular subtype, exome and targeted sequencing was performed on 85 MLL-PTD AML samples using HiSeq-2000. Genes involved in the cohesin complex (STAG2), a splicing factor (U2AF1) and a poorly studied gene, MGA were recurrently mutated, whereas NPM1, one of the most frequently mutated AML gene, was not mutated in MLL-PTD patients. Interestingly, clonality analysis suggests that IDH2/1, DNMT3A, U2AF1 and TET2 mutations are clonal and occur early, and MLL-PTD likely arises after these initial mutations. Conversely, proliferative mutations (FLT3, RAS), typically appear later, are largely subclonal and tend to be unstable. This study provides important insights for understanding the relative importance of different mutations for defining a targeted therapeutic strategy for MLL-PTD AML patients.

Published
2017

6. Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia

Author

Madan, V, Shyamsunder, P, Han, L, Mayakonda, A, Nagata, Y, Sundaresan, J, Kanojia, D, Yoshida, K, Ganesan, S, Hattori, N, Fulton, N, Tan, K-T, Alpermann, T, Kuo, M-C, Rostami, S, Matthews, J, Sanada, M, Liu, L-Z, Shiraishi, Y, Miyano, S, Chendamarai, E, Hou, H-A, Malnassy, G, Ma, T, Garg, M, Ding, L-W, Sun, Q-Y, Chien, W, Ikezoe, T, Lill, M, Biondi, A, Larson, RA, Powell, BL, Lübbert, M, Chng, WJ, Tien, H-F, Heuser, M, Ganser, A, Koren-Michowitz, M, Kornblau, SM, Kantarjian, HM, Nowak, D, Hofmann, W-K, Yang, H, Stock, W, Ghavamzadeh, A, Alimoghaddam, K, Haferlach, T, Ogawa, S, Shih, L-Y, Mathews, V, and Koeffler, HP

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Human Genome, Childhood Leukemia, Pediatric Cancer, Genetics, Rare Diseases, Hematology, Clinical Research, Pediatric, Cell Differentiation, DNA Mutational Analysis, DNA-Binding Proteins, Exome, Gene Expression Profiling, Humans, Leukemia, Promyelocytic, Acute, Nuclear Proteins, Recurrence, Transcription Factors, Immunology, Cardiovascular medicine and haematology, Clinical sciences, Oncology and carcinogenesis
Abstract

Acute promyelocytic leukemia (APL) is a subtype of myeloid leukemia characterized by differentiation block at the promyelocyte stage. Besides the presence of chromosomal rearrangement t(15;17), leading to the formation of PML-RARA (promyelocytic leukemia-retinoic acid receptor alpha) fusion, other genetic alterations have also been implicated in APL. Here, we performed comprehensive mutational analysis of primary and relapse APL to identify somatic alterations, which cooperate with PML-RARA in the pathogenesis of APL. We explored the mutational landscape using whole-exome (n=12) and subsequent targeted sequencing of 398 genes in 153 primary and 69 relapse APL. Both primary and relapse APL harbored an average of eight non-silent somatic mutations per exome. We observed recurrent alterations of FLT3, WT1, NRAS and KRAS in the newly diagnosed APL, whereas mutations in other genes commonly mutated in myeloid leukemia were rarely detected. The molecular signature of APL relapse was characterized by emergence of frequent mutations in PML and RARA genes. Our sequencing data also demonstrates incidence of loss-of-function mutations in previously unidentified genes, ARID1B and ARID1A, both of which encode for key components of the SWI/SNF complex. We show that knockdown of ARID1B in APL cell line, NB4, results in large-scale activation of gene expression and reduced in vitro differentiation potential.

Published
2016

19. Diet and Nutritional Status of Tribal’s in North Western Part of Nashik District, Maharashtra (India): Using GIS Techniques

Author

Jagadish D. Wetal, Dnyaneshwar. S. Suryawanshi, Madan V. Suryawanshi, Vivekanand D. Patil, Chatragun Bhore, and Abhijit A. Awhad

Abstract

Background: An individual's health is largely determined by nutrition, and nutrition is determined by diet, which consists of a variety of food items. As a result, eating a well-balanced and healthy diet is the single most significant element in achieving and maintaining good. The health of an individual depends to a large extent on nutrition and nutrition depends on diet, which consists of various articles of food. Hence balanced and nutritious food is the most important single factor in connection with the attainment and maintenance of health. Objective: 1) To study Nutritional deficiency disorders among the tribal population. 2) To study the composite nutritional value as per the given Weightage. 3) To examine the pattern of diet and nutrition and their availability and intake in study regions. Methods: Statistical and cartographic techniques have been used for the research work to precise conclusions. Per head per day availability foodstuff stuffs like, cereals, pulses, milk, vegetable,s etc. has beefindingnd out and shown through PHC wise isopleths maps. PPHC-whisper head per day consumption has been calculated through the sample village survey. A total of 115 villages are chosen, and 23 villages from the list of ITDP villages have randomly chosen in each tehsil. By using a probability proportional to the size of the various tribes, a total of 10 households (HHs) from each chosen village have been covered. Result: The cumulative nutritional values of cereals are derived from the total of all weight ages measured so far. The composite nutrient values for cereals were 14.72 in Peint tehsil. This method was used to quantify the composite nutrient value for pulses, edible oil, milk, vegetables, and fruits. The cumulative composite value of Peint tehsil was 67.22 when the composite nutrition values were added together. The table shows the cumulative composite nutrition values measured on a tehsil-by-tehsil basis. Conclusion: The indigenous inhabitants of the study region eat jowar, maize, wheat, and bajara as their major foods. Despite the fact that the terrain is conducive to rice farming, they still consume rice on occasion. Pulses are a staple of indigenous people's diets, which they consume on a daily basis. However, they consume very little fat-containing foods such as oil and milk in their regular diet. Similarly, just a small percentage of households include fruits and vegetables in their daily diet. These people are unable to acquire such expensive items due to their poverty. The general nutritional status is measured by computing composite nutrition values. For the entire region, the average composite nutrition value is 74.81.

Published
2022

21. The Alphavirus 6K Protein

Author

Sanz, M. A., Madan, V., Nieva, J. L., Carrasco, Luis, Atassi, M. Zouhair, editor, Berliner, Lawrence J., editor, Chang, Rowen Jui-Yoa, editor, Jörnvall, Hans, editor, Kenyon, George L., editor, Wittman-Liebold, Brigitte, editor, and Fischer, Wolfgang B., editor

Published
2005
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31. Reference Curve for Indian Role Model Scientist

Author

Kalyane, V. L., Madan, V. K., and Vijai Kumar

Subjects
B. Information use and sociology of information
Abstract

Analysis of the publication productivity of well-known Indian scientists has been documented and linear regression analysis curve is plotted which can be used to forecast promising young scientists who may become role model scientists, based on their present publication productivity considering history of their fifteen years of number of publications.

Published
2001

32. Spectrally robust graph isomorphism

Author

Madan, V., Kolla, A., Koutis, I., Sinop, A. K., Madan, V., Kolla, A., Koutis, I., and Sinop, A. K.

Abstract

We initiate the study of spectral generalizations of the graph isomorphism problem. (a) The Spectral Graph Dominance (SGD) problem: On input of two graphs G and H does there exist a permutation ? such that G ?(H)? (b) The Spectrally Robust Graph Isomorphism (?-SRGI) problem: On input of two graphs G and H, find the smallest number ? over all permutations ? such that ?(H) G ?c?(H) for some c. SRGI is a natural formulation of the network alignment problem that has various applications, most notably in computational biology. G cH means that for all vectors x we have xTLGx ? cxTLHx, where LG is the Laplacian G. We prove NP-hardness for SGD. We also present a ?3-approximation algorithm for SRGI for the case when both G and H are bounded-degree trees. The algorithm runs in polynomial time when ? is a constant. © 2018 Schloss Dagstuhl- Leibniz-Zentrum fur Informatik GmbH, Dagstuhl Publishing. All rights reserved., National Science Foundation: 1319376, CCF-1319376, CCF-1452923 Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Avast;RSJ

Published
2021

33. Spectrally robust graph isomorphism

Author

Sinop, A. K., Koutis, I., Kolla, A., Madan, V., Sinop, A. K., Koutis, I., Kolla, A., and Madan, V.

Abstract

We initiate the study of spectral generalizations of the graph isomorphism problem. (a) The Spectral Graph Dominance (SGD) problem: On input of two graphs G and H does there exist a permutation ? such that G ?(H)? (b) The Spectrally Robust Graph Isomorphism (?-SRGI) problem: On input of two graphs G and H, find the smallest number ? over all permutations ? such that ?(H) G ?c?(H) for some c. SRGI is a natural formulation of the network alignment problem that has various applications, most notably in computational biology. G cH means that for all vectors x we have xTLGx ? cxTLHx, where LG is the Laplacian G. We prove NP-hardness for SGD. We also present a ?3-approximation algorithm for SRGI for the case when both G and H are bounded-degree trees. The algorithm runs in polynomial time when ? is a constant. © 2018 Schloss Dagstuhl- Leibniz-Zentrum fur Informatik GmbH, Dagstuhl Publishing. All rights reserved., National Science Foundation: 1319376, CCF-1319376, CCF-1452923 Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Avast;RSJ

Published
2021

44. Erratum: Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia

Author

Madan, V, Shyamsunder, P, Han, L, Mayakonda, A, Nagata, Y, Sundaresan, J, Kanojia, D, Yoshida, K, Ganesan, S, Hattori, N, Fulton, N, Tan, K T, Alpermann, T, Kuo, M C, Rostami, S, Matthews, J, Sanada, M, Liu, L-Z, Shiraishi, Y, Miyano, S, Chendamarai, E, Hou, H A, Malnassy, G, Ma, T, Garg, M, Ding, L W, Sun, Q Y, Chien, W, Ikezoe, T, Lill, M, Biondi, A, Larson, R A, Powell, B L, Lübbert, M, Chng, W J, Tien, H F, Heuser, M, Ganser, A, Koren-Michowitz, M, Kornblau, S M, Kantarjian, H M, Nowak, D, Hofmann, W K, Yang, H, Stock, W, Ghavamzadeh, A, Alimoghaddam, K, Haferlach, T, Ogawa, S, Shih, L Y, Mathews, V, and Koeffler, H P

Published
2016
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