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2. Publisher Correction: The DNA sequence and analysis of human chromosome 14

Author

Heilig, Roland, Eckenberg, Ralph, Petit, Jean-Louis, Fonknechten, Núria, Da Silva, Corinne, Cattolico, Laurence, Levy, Michaël, Barbe, Valérie, de Berardinis, Véronique, Ureta-Vidal, Abel, Pelletier, Eric, Vico, Virginie, Anthouard, Véronique, Rowen, Lee, Madan, Anup, Qin, Shizhen, Sun, Hui, Du, Hui, Pepin, Kymberlie, Artiguenave, François, Robert, Catherine, Cruaud, Corinne, Brüls, Thomas, Jaillon, Olivier, Friedlander, Lucie, Samson, Gaelle, Brottier, Philippe, Cure, Susan, Ségurens, Béatrice, Anière, Franck, Samain, Sylvie, Crespeau, Hervé, Abbasi, Nissa, Aiach, Nathalie, Boscus, Didier, Dickhoff, Rachel, Dors, Monica, Dubois, Ivan, Friedman, Cynthia, Gouyvenoux, Michel, James, Rose, Madan, Anuradha, Mairey–Estrada, Barbara, Mangenot, Sophie, Martins, Nathalie, Ménard, Manuela, Oztas, Sophie, Ratcliffe, Amber, Shaffer, Tristan, Trask, Barbara, Vacherie, Benoit, Bellemere, Chadia, Belser, Caroline, Besnard-Gonnet, Marielle, Bartol–Mavel, Delphine, Boutard, Magali, Briez-Silla, Stéphanie, Combette, Stephane, Dufossé-Laurent, Virginie, Ferron, Carolyne, Lechaplais, Christophe, Louesse, Claudine, Muselet, Delphine, Magdelenat, Ghislaine, Pateau, Emilie, Petit, Emmanuelle, Sirvain-Trukniewicz, Peggy, Trybou, Arnaud, Vega-Czarny, Nathalie, Bataille, Elodie, Bluet, Elodie, Bordelais, Isabelle, Dubois, Maria, Dumont, Corinne, Guérin, Thomas, Haffray, Sébastien, Hammadi, Rachid, Muanga, Jacqueline, Pellouin, Virginie, Robert, Dominique, Wunderle, Edith, Gauguet, Gilbert, Roy, Alice, Sainte-Marthe, Laurent, Verdier, Jean, Verdier-Discala, Claude, Hillier, LaDeana, Fulton, Lucinda, McPherson, John, Matsuda, Fumihiko, Wilson, Richard, Scarpelli, Claude, Gyapay, Gábor, Wincker, Patrick, Saurin, William, Quétier, Francis, Waterston, Robert, Hood, Leroy, and Weissenbach, Jean

Published
2023
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7. 1104 Effects of Belimumab (BEL) on Renal Outcomes in Patients (pts) With Relapsed and Newly Diagnosed Active Lupus Nephritis (LN)

Author

Anders, Hans-Joachim, primary, Rovin, Brad H, additional, Zhao, Ming-Hui, additional, Malvar, Ana, additional, Hiromura, Keiju, additional, Leone, Angela Jones-, additional, Gonzalez-Rivera, Tania, additional, Gilbride, Jennifer, additional, Madan, Anuradha, additional, Green, Yulia, additional, and Roth, David A, additional

Published
2022
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11. 506 Belimumab (BEL) improves renal outcomes in active Lupus Nephritis (LN): a phase 3 randomized, Placebo (PBO)-controlled trial

Author

Rovin, Brad H, primary, Houssiau, Frédéric, additional, Furie, Richard, additional, Malvar, Ana, additional, Onno Teng, YK, additional, Contreras, Gabriel, additional, Yu, Xueqing, additional, Ji, Beulah, additional, Roth, David, additional, Kleoudis, Christi, additional, Makowiak, Susan, additional, Madan, Anuradha, additional, Gilbride, Jennifer, additional, and Green, Yulia, additional

Published
2021
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15. Analysis of the DNA sequence and duplication history of human chromosome 15

Author

Zody, Michael C., Garber, Manuel, Sharpe, Ted, Young, Sarah K., Rowen, Lee, O'Neill, Keith, Whittaker, Charles A., Kamal, Michael, Chang, Jean L., Cuomo, Christina A., Dewar, Ken, FitzGerald, Michael G., Kodira, Chinnappa D., Madan, Anup, Qin, Shizhen, Yang, Xiaoping, Abbasi, Nissa, Abouelleil, Amr, Arachchi, Harindra M., Baradarani, Lida, Birditt, Brian, Bloom, Scott, Bloom, Toby, Borowsky, Mark L., Burke, Jeremy, Butler, Jonathan, Cook, April, DeArellano, Kurt, DeCaprio, David, Dorris, III, Lester, Dors, Monica, Eichler, Evan E., Engels, Reinhard, Fahey, Jessica, Fleetwood, Peter, Friedman, Cynthia, Gearin, Gary, Hall, Jennifer L., Hensley, Grace, Johnson, Ericka, Jones, Charlien, Kamat, Asha, Kaur, Amardeep, Locke, Devin P., Madan, Anuradha, Munson, Glen, Jaffe, David B., Lui, Annie, Macdonald, Pendexter, Mauceli, Evan, Naylor, Jerome W., Nesbitt, Ryan, Nicol, Robert, O'Leary, Sinead B., Ratcliffe, Amber, Rounsley, Steven, She, Xinwei, Sneddon, Katherine M. B., Stewart, Sandra, Sougnez, Carrie, Stone, Sabrina M., Topham, Kerri, Vincent, Dascena, Wang, Shunguang, Zimmer, Andrew R., Birren, Bruce W., Hood, Leroy, Lander, Eric S., and Nusbaum, Chad

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Michael C. Zody (corresponding author) [1]; Manuel Garber [1]; Ted Sharpe [1]; Sarah K. Young [1]; Lee Rowen [2]; Keith O'Neill [1]; Charles A. Whittaker [1, 6]; Michael Kamal [...]

Published
2006
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16. The DNA sequence and analysis of human chromosome 14

Author

Heilig, Roland, Eckenberg, Ralph, Petit, Jean-Louis, Fonknechten, Núria, Da Silva, Corinne, Cattolico, Laurence, Levy, Michaël, Barbe, Valérie, de Berardinis, Véronique, Ureta-Vidal, Abel, Pelletier, Eric, Vico, Virginie, Anthouard, Véronique, Rowen, Lee, Madan, Anup, Qin, Shizhen, Sun, Hui, Du, Hui, Pepin, Kymberlie, Artiguenave, François, Robert, Catherine, Cruaud, Corinne, Brüls, Thomas, Jaillon, Olivier, Friedlander, Lucie, Samson, Gaelle, Brottier, Philippe, Cure, Susan, Ségurens, Béatrice, Anière, Franck, Samain, Sylvie, Crespeau, Hervé, Abbasi, Nissa, Aiach, Nathalie, Boscus, Didier, Dickhoff, Rachel, Dors, Monica, Dubois, Ivan, Friedman, Cynthia, Gouyvenoux, Michel, James, Rose, Madan, Anuradha, Mairey–Estrada, Barbara, Mangenot, Sophie, Martins, Nathalie, Ménard, Manuela, Oztas, Sophie, Ratcliffe, Amber, Shaffer, Tristan, Trask, Barbara, Vacherie, Benoit, Bellemere, Chadia, Belser, Caroline, Besnard-Gonnet, Marielle, Bartol–Mavel, Delphine, Boutard, Magali, Briez-Silla, Stéphanie, Combette, Stephane, Dufossé-Laurent, Virginie, Ferron, Carolyne, Lechaplais, Christophe, Louesse, Claudine, Muselet, Delphine, Magdelenat, Ghislaine, Pateau, Emilie, Petit, Emmanuelle, Sirvain-Trukniewicz, Peggy, Trybou, Arnaud, Vega-Czarny, Nathalie, Bataille, Elodie, Bluet, Elodie, Bordelais, Isabelle, Dubois, Maria, Dumont, Corinne, Guérin, Thomas, Haffray, Sébastien, Hammadi, Rachid, Muanga, Jacqueline, Pellouin, Virginie, Robert, Dominique, Wunderle, Edith, Gauguet, Gilbert, Roy, Alice, Sainte-Marthe, Laurent, Verdier, Jean, Verdier-Discala, Claude, Hillier, LaDeana, Fulton, Lucinda, McPherson, John, Matsuda, Fumihiko, Wilson, Richard, Scarpelli, Claude, Gyapay, Gábor, Wincker, Patrick, Saurin, William, Quétier, Francis, Waterston, Robert, Hood, Leroy, and Weissenbach, Jean

Published
2003
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19. A physical map of the human genome

Author

McPherson, John D., Marra, Marco, Hillier, LaDeana, Waterston, Robert H., Chinwalla, Asif, Wallis, John, Sekhon, Mandeep, Wylie, Kristine, Mardis, Elaine R., Wilson, Richard K., Fulton, Robert, Kucaba, Tamara A., Wagner-McPherson, Caryn, Barbazuk, William B., Gregory, Simon G., Humphray, Sean J., French, Lisa, Evans, Richard S., Bethel, Graeme, Whittaker, Adam, Holden, Jane L., McCann, Owen T., Dunham, Andrew, Soderlund, Carol, Scott, Carol E., Bentley, David R., Schuler, Gregory, Chen, Hsiu-Chuan, Jang, Wonhee, Green, Eric D., Idol, Jacquelyn R., Maduro, Valerie V. Braden, Montgomery, Kate T., Lee, Eunice, Miller, Ashley, Emerling, Suzanne, Kucherlapati, Raju, Gibbs, Richard, Scherer, Steve, Gorrell, J. Harley, Sodergren, Erica, Clerc-Blankenburg, Kerstin, Tabor, Paul, Naylor, Susan, Garcia, Dawn, de Jong, Pieter J., Catanese, Joseph J., Nowak, Norma, Osoegawa, Kazutoyo, Qin, Shizhen, Rowen, Lee, Madan, Anuradha, Dors, Monica, Hood, Leroy, Trask, Barbara, Friedman, Cynthia, Massa, Hillary, Cheung, Vivian G., Kirsch, Ilan R., Reid, Thomas, Yonescu, Raluca, Weissenbach, Jean, Bruls, Thomas, Heilig, Roland, Branscomb, Elbert, Olsen, Anne, Doggett, Norman, Cheng, Jan-Fang, Hawkins, Trevor, Myers, Richard M., Shang, Jin, Ramirez, Lucia, Schmutz, Jeremy, Velasquez, Olivia, Dixon, Kami, Stone, Nancy E., Cox, David R., Haussler, David, Kent, W. James, Furey, Terrence, Rogic, Sanja, Kennedy, Scot, Jones, Steven, Rosenthal, Andre, Wen, Gaiping, Schilhabel, Markus, Gloeckner, Gernot, Nyakatura, Gerald, Siebert, Reiner, Schlegelberger, Brigitte, Korenberg, Julie, Chen, Xiao-Ning, Fujiyama, Asao, Hattori, Masahira, Toyoda, Atsushi, Yada, Tetsushi, Park, Hong-Seok, Sakaki, Yoshiyuki, Shimizu, Nobuyoshi, Asakawa, Shuichi, Kawasaki, Kazuhiko, Sasaki, Takashi, Shintani, Ai, Shimizu, Atsushi, Shibuya, Kazunori, Kudoh, Jun, Minoshima, Shinsei, Ramser, Juliane, Seranski, Peter, Hoff, Celine, Poustka, Annemarie, Reinhardt, Richard, and Lehrach, Hans

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): The International Human Genome Mapping Consortium ; Washington University School of Medicine, Genome Sequencing Center: ; John D. McPherson (corresponding author) [1]; Marco Marra [1]; LaDeana Hillier [1]; Robert [...]

Published
2001
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20. LB001EFFICACY AND SAFETY OF BELIMUMAB IN PATIENTS WITH ACTIVE LUPUS NEPHRITIS: A PHASE 3, RANDOMISED, PLACEBO-CONTROLLED TRIAL

Author

Rovin, Brad, primary, Houssiau, Frédéric A, primary, Furie, Richard, primary, Malvar, Ana, primary, Teng, Y K O, primary, Mok, Chi Chiu, primary, Contreras, Gabriel, primary, Yu, Xueqing, primary, Dolff, Sebastian, primary, Ji, Beulah, primary, Roth, David, primary, Kleoudis, Christi, primary, Bass, Damon, primary, Madan, Anuradha, primary, Wright, Amanda, primary, Barnett, Carly, primary, and Green, Yulia, primary

Published
2020
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22. In situ detection of transcripts for ribulose-1,5-bisphosphate carboxylase in cyanobacterial heterocysts

Author

Madan, Anuradha P. and Nierzwicki-Bauer, Sandra A.

Subjects
Ribulosebiphosphate carboxylase -- Analysis, Genetic transcription -- Analysis, Cyanobacteria -- Research, Biological sciences
Abstract

Developmental and environmental regulation of the transcriptional control of genes involved in nitrogen fixation and photosynthesis occurs in Azolla-Anabaena. The rbcS and rbcL gene transcripts exist in vegetative cell and heterocysts with the Azolla-Anabaena symbiosis. Only vegetative cells of the free living cyanobacterium Anabaena strain 7120 contain transcripts of rbcLS.

Published
1993

25. Efficacy and Safety of Danirixin (GSK1325756) Co-administered With Standard-of-Care Antiviral (Oseltamivir): A Phase 2b, Global, Randomized Study of Adults Hospitalized With Influenza

Author

Madan, Anuradha, primary, Chen, Shuguang, additional, Yates, Phillip, additional, Washburn, Michael L, additional, Roberts, Grace, additional, Peat, Andrew J, additional, Tao, Yu, additional, Parry, Michael F, additional, Barnum, Otis, additional, McClain, Micah T, additional, and Roy-Ghanta, Sumita, additional

Published
2019
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27. Extended antigen sparing potential of AS03-adjuvanted pandemic H1N1 vaccines in children, and immunological equivalence of two formulations of AS03-adjuvanted H1N1 vaccines: results from two randomised trials

Author

Launay, Odile, primary, Duval, Xavier, additional, Fitoussi, Serge, additional, Jilg, Wolfgang, additional, Kerdpanich, Angkool, additional, Montellano, May, additional, Schwarz, Tino F, additional, Watanveerade, Veerachai, additional, Wenzel, Jürgen J, additional, Zalcman, Gerard, additional, Bambure, Vinod, additional, Li, Ping, additional, Caplanusi, Adrian, additional, Madan, Anuradha, additional, Gillard, Paul, additional, and Vaughn, David W, additional

Published
2013
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28. Analysis of the DNA sequence and duplication history of human chromosome 15

Author

Zody, Michael, Garber, Manuel, Sharpe, Ted, Young, Sarah, Rowen, Lee, O'Neill, Keith, Whittaker, Charles, Kamal, Michael, Chang, Jean, Cuomo, Christina, Dewar, Ken, FitzGerald, Michael, Kodira, Chinnappa, Madan, Anup, Qin, Shizhen, Yang, Xiaoping, Abbasi, Nissa, Abouelleil, Amr, Arachchi, Harindra, Baradarani, Lida, Birditt, Brian, Bloom, Scott, Bloom, Toby, Borowsky, Mark, Burke, Jeremy, Butler, Jonathan, Cook, April, DeArellano, Kurt, DeCaprio, David, Dorris, Lester, Dors, Monica, Eichler, Evan, Engels, Reinhard, Fahey, Jessica, Fleetwood, Peter, Friedman, Cynthia, Gearin, Gary, Hall, Jennifer, Hensley, Grace, Johnson, Ericka, Jones, Charlien, Kamat, Asha, Kaur, Amardeep, Locke, Devin, Madan, Anuradha, Munson, Glen, Jaffe, David, Lui, Annie, Macdonald, Pendexter, Mauceli, Evan, Naylor, Jerome, Nesbitt, Ryan, Nicol, Robert, O'Leary, Sinéad, Ratcliffe, Amber, Rounsley, Steven, She, Xinwei, Sneddon, Katherine, Stewart, Sandra, Sougnez, Carrie, Stone, Sabrina, Topham, Kerri, Vincent, Dascena, Wang, Shunguang, Zimmer, Andrew, Birren, Bruce, Hood, Leroy, Lander, ic, Nusbaum, Chad, Zody, Michael, Garber, Manuel, Sharpe, Ted, Young, Sarah, Rowen, Lee, O'Neill, Keith, Whittaker, Charles, Kamal, Michael, Chang, Jean, Cuomo, Christina, Dewar, Ken, FitzGerald, Michael, Kodira, Chinnappa, Madan, Anup, Qin, Shizhen, Yang, Xiaoping, Abbasi, Nissa, Abouelleil, Amr, Arachchi, Harindra, Baradarani, Lida, Birditt, Brian, Bloom, Scott, Bloom, Toby, Borowsky, Mark, Burke, Jeremy, Butler, Jonathan, Cook, April, DeArellano, Kurt, DeCaprio, David, Dorris, Lester, Dors, Monica, Eichler, Evan, Engels, Reinhard, Fahey, Jessica, Fleetwood, Peter, Friedman, Cynthia, Gearin, Gary, Hall, Jennifer, Hensley, Grace, Johnson, Ericka, Jones, Charlien, Kamat, Asha, Kaur, Amardeep, Locke, Devin, Madan, Anuradha, Munson, Glen, Jaffe, David, Lui, Annie, Macdonald, Pendexter, Mauceli, Evan, Naylor, Jerome, Nesbitt, Ryan, Nicol, Robert, O'Leary, Sinéad, Ratcliffe, Amber, Rounsley, Steven, She, Xinwei, Sneddon, Katherine, Stewart, Sandra, Sougnez, Carrie, Stone, Sabrina, Topham, Kerri, Vincent, Dascena, Wang, Shunguang, Zimmer, Andrew, Birren, Bruce, Hood, Leroy, Lander, ic, and Nusbaum, Chad

Abstract

Here we present a finished sequence of human chromosome 15, together with a high-quality gene catalogue. As chromosome 15 is one of seven human chromosomes with a high rate of segmental duplication, we have carried out a detailed analysis of the duplication structure of the chromosome. Segmental duplication in chromosome 15 are largely clustered in two regions, on proximal and distal 15q; the proximal region is notable because recombination among the segmental duplications can result in deletions causing Prader-Willi and Angelman syndromes. Sequence analysis shows that the proximal and distal regions of 15q share extensive ancient similarity. Using a simple approach, we have been able to reconstruct many of the events by which the current duplication structure arose. We find that most of the intrachromosomal duplications seem to share a common ancestry. Finally, we demonstrate that some remaining gaps in the genome sequence are probably due to structural polymorphisms between haplotypes; this may explain a significant fraction of the gaps remaining in the human genome.

Published
2006
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31. Extended antigen sparing potential of AS03-adjuvanted pandemic H1N1 vaccines in children, and immunological equivalence of two formulations of AS03-adjuvanted H1N1 vaccines: results from two randomised trials

Author

Launay, Odile, Duval, Xavier, Fitoussi, Serge, Jilg, Wolfgang, Kerdpanich, Angkool, Montellano, May, Schwarz, Tino F., Watanveerade, Veerachai, Wenzel, Jürgen J., Zalcman, Gerard, Bambure, Vinod, Li, Ping, Caplanusi, Adrian, Madan, Anuradha, Gillard, Paul, and Vaughn, David W.

Subjects
H1N1, Pandemic influenza vaccine, Influenza virus, Children, Adults, Persistence, Immunogenicity, Manufacturing capacity, Antigen dose reduction, 610 Medizin, 3. Good health
Abstract

Background Pandemic influenza vaccine manufacturing capacity and distribution agility is enhanced through the availability of equivalent antigen-sparing vaccines. We evaluated equivalence in terms of immunogenicity between GlaxoSmithKline Vaccines’ A/California/7/2009 (H1N1)v-like-AS03 vaccines manufactured in Dresden (D-Pan), and Quebec (Q-Pan). Methods In two studies, 334 adults 18-60 years of age received 2 doses of D-Pan or Q-Pan containing 3.75 μg haemagglutinin antigen (HA) adjuvanted with AS03A administered 21 days apart, and 209 children 3-9 years of age received 1 reduced dose of D-Panor Q-Pan (0.9 μg HA) or Q-Pan (1.9 μg HA) with AS03B. Haemagglutination inhibition (HI) titres were assessed before and 21 days post-vaccination. HI persistence was assessed after 12 months in adults and 6 months in children. Results Pre-defined criteria for immunological equivalence of Q-Pan versus D-Pan were achieved in both populations. After one vaccine dose, ≥97.6% of adults and children had HI titres ≥1:40, with increases in titre ≥25.7-fold. CHMP and CBER regulatory acceptance criteria for influenza vaccines were exceeded by all groups in both studies at Day 21. In adults,the percentage with HI titres ≥1:40 at Month 12 was 82.9% (Q-Pan) and 84.0% (D-Pan). In children, the percentages at Month 6 were 75.3.3% (Q-Pan0.9), 85.1% (D-Pan0.9) and 79.3% (Q-Pan1.9). Safety profile of the study vaccines was consistent with previously published data. Conclusion Two studies indicate that A/California/7/2009 (H1N1)v-like HA manufactured at two sites and combined with AS03 are equivalent in terms of immunogenicity in adults and children and highly immunogenic. Different HA doses elicited an adequate immune response through 180 days post-vaccination in children 3-9 years of age.

32. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Author

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, and Malek J

Subjects
Animals, Computational Biology, DNA Primers, Humans, Mice, National Institutes of Health (U.S.), Rats, United States, Xenopus laevis genetics, Zebrafish genetics, Cloning, Molecular methods, DNA, Complementary genetics, DNA, Complementary metabolism, Gene Library, Open Reading Frames physiology
Abstract

The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5'-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. Currently, more than 11,000 human and 10,000 mouse genes are represented in MGC by at least one clone with a full ORF. The random selection approach is now reaching a saturation point, and a transition to protocols targeted at the missing transcripts is now required to complete the mouse and human collections. Comparison of the sequence of the MGC clones to reference genome sequences reveals that most cDNA clones are of very high sequence quality, although it is likely that some cDNAs may carry missense variants as a consequence of experimental artifact, such as PCR, cloning, or reverse transcriptase errors. Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline.

Published
2004
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33. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

Author

Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, and Marra MA

Subjects
Algorithms, Animals, DNA, Complementary analysis, Gene Library, Humans, Mice, Open Reading Frames, DNA, Complementary chemistry, Sequence Analysis, DNA
Abstract

The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify and sequence a cDNA clone containing a complete ORF for each human and mouse gene. ESTs were generated from libraries enriched for full-length cDNAs and analyzed to identify candidate full-ORF clones, which then were sequenced to high accuracy. The MGC has currently sequenced and verified the full ORF for a nonredundant set of >9,000 human and >6,000 mouse genes. Candidate full-ORF clones for an additional 7,800 human and 3,500 mouse genes also have been identified. All MGC sequences and clones are available without restriction through public databases and clone distribution networks (see http:mgc.nci.nih.gov).

Published
2002
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