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141 results on '"Mackay, Hannah"'

1. USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication

Author

Mackay, Hannah L., Stone, Helen R., Ronson, George E., Ellis, Katherine, Lanz, Alexander, Aghabi, Yara, Walker, Alexandra K., Starowicz, Katarzyna, Garvin, Alexander J., Van Eijk, Patrick, Koestler, Stefan A., Anthony, Elizabeth J., Piberger, Ann Liza, Chauhan, Anoop S., Conway-Thomas, Poppy, Vaitsiankova, Alina, Vijayendran, Sobana, Beesley, James F., Petermann, Eva, Brown, Eric J., Densham, Ruth M., Reed, Simon H., Dobbs, Felix, Saponaro, Marco, and Morris, Joanna R.

Published
2024
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2. Exploring Culturally Responsive Teaching and Student-Created Videos in an At-Risk Middle School Classroom

Author

Mackay, Hannah and Strickland, Martha J.

Abstract

As the United States public school classrooms encounter notable shifts in student demographics and increased access to technology, teachers face the dual challenges of cultural and digital differences as they attempt to build relationships with students and develop responsive and relevant instruction. Framed by culturally responsive teaching (CRT), this qualitative study explored how one middle school teacher and his students in two summer school English classes interacted with and responded to novel technology-based instructional approach that sought to connect the students' lives outside of school to the classroom. The findings suggest that involving the students within this culturally responsive teaching approach using student-created videos informs the contribution of both the teacher and the students for connecting home and school contexts with a CRT framework.

Published
2018

3. The biology of mutant p53 associated cell-in-cell formation in cancer

Author

Mackay, Hannah

Subjects
616.89, Thesis
Abstract

A cell-in-cell (CIC) structure is formed when one viable cell becomes internalised within a neighbouring cell. CIC structures have been observed in many human tumours, in which their occurrence has been associated with high-grade disease or metastasis. On the contrary, CIC structures have also been suggested to be anti-tumourigenic, triggering death of matrix-detached cells. The findings presented here show how, in adherent cancer cell lines, CIC structures form, and that this involves a mechanism of live cell 'phagocytic' engulfment. Interestingly, mutant p53 status affects both the frequency and subsequent outcomes of these structures. Internalised cells ultimately either escaped, died, or divided and often appeared to physically interfere in the cellular divisions of host cells. Host cells were observed to undergo failed and aberrant division events upon disruption of cytokinesis due to the internalised cell. For cells without p53, this lead to host cell death. In contrast, mutant p53 host cells survived aberrant divisions, often becoming multinucleated and undergoing tripolar mitoses. In tumour xenograft models, mutant p53/null p53 cell co-cultures which had increased occurrence of CIC structures and also higher final tumour volume on average. Furthermore, CIC structures were present in 50% of archival human lung cancers in a cohort of 273 patients. CIC occurrence was an independent predictor of poor outcome, and was also associated with mutant p53 expression, intra-tumour genomic heterogeneity and genomic instability. These findings suggest that tumour cell engulfment activity, in combination with mutant p53 status is pro-tumourigenic in lung cancers.

Published
2019
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4. Disruptive non-fluorinated photoacid generators using computational chemistry and library design

Author

LaBeaume, Paul, primary, Hernandez, Kenneth, additional, Vitaku, Edon, additional, Marangoni, Tomas, additional, Aqad, Emad, additional, Li, Mingqi, additional, Hoelzel, Conner, additional, Lachowski, Joseph, additional, Hayes, Mark, additional, Wong, Sabrina, additional, Li, Jingyi, additional, Kwok, Amy, additional, Huang, Wanyi, additional, Park, Jong, additional, He, Huan, additional, Mackay, Hannah, additional, Liu, Cong, additional, Cameron, James, additional, Xu, Chengbai, additional, Xie, Qiuzhe, additional, and Petrillo, Karen, additional

Published
2024
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5. Isomerization of BRCA1-BARD1 promotes replication fork protection

Author

Daza-Martin, Manuel, Starowicz, Katarzyna, Jamshad, Mohammed, Tye, Stephanie, Ronson, George E., MacKay, Hannah L., and Chauhan, Anoop Singh

Subjects
Genetic research, Replication fork -- Research, Isomerization -- Genetic aspects, Genetic regulation -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The integrity of genomes is constantly threatened by problems encountered by the replication fork. BRCA1, BRCA2 and a subset of Fanconi anaemia proteins protect stalled replication forks from degradation by nucleases, through pathways that involve RAD51. The contribution and regulation of BRCA1 in replication fork protection, and how this role relates to its role in homologous recombination, is unclear. Here we show that BRCA1 in complex with BARD1, and not the canonical BRCA1-PALB2 interaction, is required for fork protection. BRCA1-BARD1 is regulated by a conformational change mediated by the phosphorylation-directed prolyl isomerase PIN1. PIN1 activity enhances BRCA1-BARD1 interaction with RAD51, thereby increasing the presence of RAD51 at stalled replication structures. We identify genetic variants of BRCA1-BARD1 in patients with cancer that exhibit poor protection of nascent strands but retain homologous recombination proficiency, thus defining domains of BRCA1-BARD1 that are required for fork protection and associated with cancer development. Together, these findings reveal a BRCA1-mediated pathway that governs replication fork protection. BRCA1-BARD1 has a role in replication fork protection that is mediated by a mechanism of phosphorylation-targeted isomerization of BRCA1 and is independent of the canonical interaction between BRCA1 and PALB2., Author(s): Manuel Daza-Martin [sup.1] [sup.3] , Katarzyna Starowicz [sup.1] , Mohammed Jamshad [sup.1] , Stephanie Tye [sup.2] , George E. Ronson [sup.1] , Hannah L. MacKay [sup.1] , Anoop Singh [...]

Published
2019
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9. Patterns of Client Emotion in Helpful Sessions of Cognitive-Behavioral and Psychodynamic-Interpersonal Therapy

Author

Mackay, Hannah C., Barkham, Michael, and Stiles, William B.

Abstract

Whereas cognitive-behavioral (CB) therapy sessions aim to be instructive and encouraging, psychodynamic-interpersonal (PI) sessions aim to be exploratory and may be emotionally painful. Raters rated degree of pleasure and arousal in each sentence of client speech in CB and PI sessions (N=18) that therapists had identified as particularly helpful. Client emotion in PI sessions was less pleasant, on average, than client emotion in CB sessions; emotion was most negative in the middle of the PI sessions. Within sessions, arousal tended to follow a U-shaped course for CB clients but an inverted U-shaped course for PI clients. The results support suggestions that these two therapeutic approaches operate by different emotional mechanisms.

Published
2002

10. Staying with the Feeling: An Anger Event in Psychodynamic-Interpersonal Therapy.

Author

Mackay, Hannah C., Barkham, Michael, and Stiles, William B.

Abstract

A therapy event where the client expressed anger through the technique of "staying with feelings" is analyzed intensively. The client's perspective and observer ratings are reported. Experiential and interpersonal rationales for staying with feelings are compared with data describing change processes; a possible mechanism of change is identified. (Author/EMK)

Published
1998

11. Dr. A. Oveta Fuller talks FDA advisory committee's votes on COVID-19 vaccines, vaccine hesitancy

Author

Mackay, Hannah

Subjects
Pfizer Inc., Vaccination, Drug approval, Vaccines, Coronaviruses, Pharmaceutical industry, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay The Michigan Daily sat down with Dr. A. Oveta Fuller, associate professor of microbiology and immunology and member of the FDA vaccine and biological products advisory committee. [...]

Published
2021

12. FDA grants full approval to Pfizer-BioNTech COVID-19 vaccine

Author

Mackay, Hannah

Subjects
United States. Food and Drug Administration, Pfizer Inc., Drug approval, Vaccines, Pharmaceutical industry, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay The Food and Drug Administration granted full approval to Pfizer-BioNTech's COVID-19 vaccine for individuals 16 and older Monday morning. Pfizer-BioNTech's vaccine is now the first COVID-19 vaccine [...]

Published
2021

15. All Michigan adults eligible for the vaccine starting April 5, Detroit opens mass vaccination site with FEMA

Author

Gooding, Lily and Mackay, Hannah

Subjects
United States. Centers for Disease Control and Prevention, United States. Federal Emergency Management Agency, Vaccination, Adults, Emergency management, News, opinion and commentary, Sports and fitness
Abstract

Byline: Lily Gooding & Hannah Mackay All Michigan adults will be eligible for COVID-19 vaccinations beginning April 5, Gov. Gretchen Whitmer announced Friday. Whitmer also announced Friday the opening of [...]

Published
2021

16. Appraisal of published reviews of research on psychotherapy and counseling with adults 1990-1998

Author

Mackay, Hannah C., Barkham, Michael, Rees, Anne, and Stiles, William B.

Subjects
Psychotherapy -- Termination, Psychotherapy -- Research, Psychological research -- Evaluation, Psychology and mental health
Abstract

Reviews and meta-analyses of research on adult psychotherapy and counseling with adults published in English from 1990 to 1998 (N = 255) were rated according to the criteria advanced by A. D. Oxman and G. H. Guyatt (1988). A majority of the reviews fell substantially short of these basic standards; on average, review articles met only half of the 8 criteria, and only 20% met 7 or more of the criteria. Common deficiencies included failure to describe comprehensive search methods used to locate studies; failure to explain inclusion and exclusion criteria for studies; and failure to provide reliable, unbiased assessments of the studies reviewed. The reviews showed no tendency to improve over the period studied.

Published
2003

17. Experts discuss new testing plans, vaccine shortage at first COVID-19 briefing of 2021

Author

Mackay, Hannah

Subjects
Vaccination, College presidents -- Planning, Vaccines -- Planning, Company business planning, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay Experts discuss new testing plans, vaccine shortage at first COVID-19 briefing of 2021 Friday, January 15, 2021 - 11:57pm University of Michigan President Mark Schlissel joined several [...]

Published
2021

18. Pinball Pete's fundraises to keep their doors open during the pandemic

Author

Mackay, Hannah

Subjects
Epidemics -- Michigan, Fund raising events, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay Pinball Pete's fundraises to keep their doors open during the pandemic Sunday, December 27, 2020 - 5:50pm Pinball Pete's started a fundraiser to fight closing permanently due [...]

Published
2020

19. FDA approves first COVID-19 vaccine as University officials prepare for distribution

Author

Mackay, Hannah and Coletti, Dominic

Subjects
United States. Food and Drug Administration, Pfizer Inc., Vaccines, Drug approval, COVID-19, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay & Dominic Coletti FDA approves first COVID-19 vaccine as University officials prepare for distribution Friday, December 11, 2020 - 9:13pm The Food and Drug Administration gave emergency [...]

Published
2020

20. Mackinac Center Legal Foundation sues the University of Michigan for documents regarding the state shut down and COVID-19 response

Author

Mackay, Hannah

Subjects
Freedom of information -- Cases, COVID-19 -- Cases, Company legal issue, News, opinion and commentary, Sports and fitness, Freedom of Information Act, University of Michigan -- Cases
Abstract

Byline: Hannah Mackay Mackinac Center Legal Foundation sues the University of Michigan for documents regarding the state shut down and COVID-19 response Tuesday, December 8, 2020 - 11:21am . Buy [...]

Published
2020

21. Armed crowd gathers outside Michigan Secretary of State Jocelyn Benson's home to protest unsubstantiated election fraud

Author

Mackay, Hannah

Subjects
Political protest -- Demonstrations and protests, Activists -- Demonstrations and protests, Election fraud -- Demonstrations and protests, Political issue, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay Armed crowd gathers outside Michigan Secretary of State Jocelyn Benson's home to protest unsubstantiated election fraud Sunday, December 6, 2020 - 8:22pm . Buy this photo Alec [...]

Published
2020

22. In anticipation of another remote semester, CAPS increases number of staff counselors

Author

Mackay, Hannah and Dougall, Jared

Subjects
Mental health -- Statistics, Company business planning, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay & Jared Dougall In anticipation of another remote semester, CAPS increases number of staff counselors Sunday, December 6, 2020 - 8:14pm With a more stringent, fully-online winter [...]

Published
2020

24. Untitled ItemThe biology of mutant p53 associated cell-in-cell formation in cancer

Author

Mackay, Hannah

Subjects
Uncategorized
Abstract

A cell-in-cell (CIC) structure is formed when one viable cell becomes internalised withina neighbouring cell. CIC structures have been observed in many human tumours, inwhich their occurrence has been associated with high-grade disease or metastasis. Onthe contrary, CIC structures have also been suggested to be anti-tumourigenic,triggering death of matrix-detached cells. The findings presented here show how, inadherent cancer cell lines, CIC structures form, and that this involves a mechanism oflive cell ‘phagocytic’ engulfment. Interestingly, mutant p53 status affects both thefrequency and subsequent outcomes of these structures. Internalised cells ultimatelyeither escaped, died, or divided and often appeared to physically interfere in thecellular divisions of host cells. Host cells were observed to undergo failed and aberrantdivision events upon disruption of cytokinesis due to the internalised cell. For cellswithout p53, this lead to host cell death. In contrast, mutant p53 host cells survivedaberrant divisions, often becoming multinucleated and undergoing tripolar mitoses. Intumour xenograft models, mutant p53/null p53 cell co-cultures which had increasedoccurrence of CIC structures and also higher final tumour volume on average.Furthermore, CIC structures were present in 50% of archival human lung cancers in acohort of 273 patients. CIC occurrence was an independent predictor of poor outcome,and was also associated with mutant p53 expression, intra-tumour genomicheterogeneity and genomic instability. These findings suggest that tumour cellengulfment activity, in combination with mutant p53 status is pro-tumourigenic in lungcancers.

Published
2019
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View/download PDF

25. Michigan issues three-week epidemic order closing schools and indoor dining as COVID-19 cases spike

Author

Mackay, Hannah and Weinstein, Liat

Subjects
Michigan. Department of Health and Human Services, Epidemics -- Michigan, COVID-19, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay & Liat Weinstein Michigan issues three-week epidemic order closing schools and indoor dining as COVID-19 cases spike Sunday, November 15, 2020 - 6:47pm Governor Gretchen Whitmer speaks [...]

Published
2020

26. With canceled winter housing contracts, freshmen make plans for next semester

Author

Mackay, Hannah

Subjects
College presidents, Contract agreement, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay With canceled winter housing contracts, freshmen make plans for next semester Saturday, November 14, 2020 - 5:00pm Many freshmen scramble to find housing after winter academic plans [...]

Published
2020

27. City Council talks police oversight, EPA involvement in Gelman plume cleanup

Author

Mackay, Hannah

Subjects
United States. Environmental Protection Agency -- Officials and employees, City councils, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay City Council talks police oversight, EPA involvement in Gelman plume cleanup Thursday, November 5, 2020 - 8:22pm . Buy this photo Courtesy of Hannah Mackay Hannah Mackay [...]

Published
2020

29. The Michigan Daily's 2020 local election guide

Author

Mackay, Hannah and Payne, Sarah

Subjects
Voting, Voter registration, News, opinion and commentary, Sports and fitness
Abstract

Byline: HANNAH MACKAY & SARAH PAYNE The Michigan Daily's 2020 local election guide Wednesday, October 14, 2020 - 6:42pm . Buy this photo Miles Macklin/Daily HANNAH MACKAY & SARAH PAYNE [...]

Published
2020

30. The Michigan Daily's 2020 state and federal election guide

Author

Mackay, Hannah and Payne, Sarah

Subjects
News, opinion and commentary, Sports and fitness, University of Michigan. Law School
Abstract

Byline: Hannah Mackay & Sarah Payne The Michigan Daily's 2020 state and federal election guide Tuesday, October 13, 2020 - 7:39pm . Buy this photo Design by Meghana Tummala Hannah [...]

Published
2020

34. City Council talks police union contract, short term rental property regulations

Author

Mackay, Hannah

Subjects
City councils, Contract agreement, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay City Council talks police union contract, short term rental property regulations Tuesday, September 8, 2020 - 8:41pm . Buy this photo Courtesy of Hannah Mackay Hannah Mackay [...]

Published
2020

35. Six months later, here's what treating COVID-19 looks like at Michigan Medicine

Author

Mackay, Hannah

Subjects
Evidence-based medicine, Medical personnel, COVID-19, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay Six months later, here's what treating COVID-19 looks like at Michigan Medicine Tuesday, September 8, 2020 - 8:10pm It has been six months since the first COVID-19 [...]

Published
2020

36. Whitmer announces reopening of businesses, nonessential medical care

Author

MacKay, Hannah

Subjects
Patients -- Care and treatment, Safety regulations, Economic recovery, Automotive dealers, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah MacKay Whitmer announces reopening of businesses, nonessential medical care Thursday, May 21, 2020 - 11:08am Governor Gretchen Whitmer announced more openings for Michigan Thursday morning. Buy this photo [...]

Published
2020

37. 'U' seeks to resolve Anderson misconduct claims outside of court

Author

Mackay, Hannah

Subjects
Sexual abuse, Athletic directors, Physicians, Sex crimes, Courts, Journalists, News, opinion and commentary, Sports and fitness, University of Michigan
Abstract

Byline: Hannah Mackay 'U' seeks to resolve Anderson misconduct claims outside of court Tuesday, April 28, 2020 - 12:40pm University of Michigan announced intentions to resolve misconduct claims against late [...]

Published
2020

39. Governor Whitmer optimistic that COVID-19 curve in Michigan is flattening

Author

Mackay, Hannah

Subjects
COVID-19, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay Governor Whitmer optimistic that COVID-19 curve in Michigan is flattening Monday, April 13, 2020 - 8:22pm Governor Gretchen Whitmer says she is optimistic about the state of [...]

Published
2020

41. Students, faculty talk impact of coronavirus spread

Author

Mackay, Hannah and Lee, Jasmin

Subjects
Journalists, Novels, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay & Jasmin Lee Students, faculty talk impact of coronavirus spread Wednesday, March 11, 2020 - 11:42am . Buy this photo Design by Lauren Kuze Hannah Mackay & [...]

Published
2020

43. Ethics, Society and Computing: Escaping inequality in technology

Author

Mackay, Hannah

Subjects
Ethics, Equality, Technology, Associations, Journalists, Company business management, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay Ethics, Society and Computing: Escaping inequality in technology Wednesday, February 19, 2020 - 8:10pm . Buy this photo design by Aya Salim Hannah Mackay Daily Staff Reporter [...]

Published
2020

44. Professor and research fellow talks financial inclusion, fintech developments

Author

Mackay, Hannah

Subjects
Technology, Finance, Journalists, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay Professor and research fellow talks financial inclusion, fintech developments Wednesday, February 12, 2020 - 9:11pm Adrienne Harris discusses financial inclusion at Blau Hall Wednesday evening. Buy this [...]

Published
2020

45. Zingerman's baker Dan Michniewicz announces candidacy for City Council

Author

Mackay, Hannah

Subjects
City councils, Democratic socialism, Socialists, Activists, Journalists, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay Zingerman's baker Dan Michniewicz announces candidacy for City Council Monday, February 10, 2020 - 8:07pm Hannah Mackay Daily Staff Reporter Zingerman's Bakehouse baker Dan Michniewicz entered the [...]

Published
2020

46. Study abroad program canceled in response to Wuhan Coronavirus outbreak

Author

Mackay, Hannah

Subjects
Journalists, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay Study abroad program canceled in response to Wuhan Coronavirus outbreak Wednesday, February 5, 2020 - 3:03pm . Buy this photo Design by Aya Salim Hannah Mackay Daily [...]

Published
2020

47. Faculty senate town hall discusses revisions to tenure bylaws

Author

Mackay, Hannah

Subjects
Journalists, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay Faculty senate town hall discusses revisions to tenure bylaws Monday, February 3, 2020 - 8:56pm Chemical Engineering Chair Sharon Glotzer discusses previous feedback in regards to the [...]

Published
2020

48. University reacts to novel coronavirus outbreak and potential infections

Author

Mackay, Hannah

Subjects
Travel warnings -- Health aspects -- Safety and security measures, Travel -- Michigan -- China -- Health aspects -- Safety and security measures, Travelers -- Health aspects -- Safety and security measures -- Planning, Infection -- Health aspects -- Safety and security measures, College students, Email, Journalists, Novels, Company business planning, News, opinion and commentary, Sports and fitness, University of Michigan -- Safety and security measures -- Planning
Abstract

Byline: Hannah Mackay University reacts to novel coronavirus outbreak and potential infections Tuesday, January 28, 2020 - 5:06pm . Buy this photo Design by Michelle Fan Hannah Mackay Daily Staff [...]

Published
2020

49. Elevation Burger closes both Ann Arbor locations

Author

Mackay, Hannah and Forrest, Julia

Subjects
Journalists, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay & Julia Forrest Elevation Burger closes both Ann Arbor locations Monday, January 27, 2020 - 9:55pm Both of Ann Arbor's Elevation Burger restaurants unexpectedly closed permanently. Buy [...]

Published
2020

50. Elixir Vitae coffee shop shuts doors after nearly two decades

Author

Mackay, Hannah

Subjects
Restaurants, Coffee (Beverage), Journalists, News, opinion and commentary, Sports and fitness
Abstract

Byline: Hannah Mackay Elixir Vitae coffee shop shuts doors after nearly two decades Tuesday, January 14, 2020 - 6:48pm The coffeeshop Elixir Vitae shut its doors on Dec. 20 after [...]

Published
2020

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