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472 results on '"Mackay, Clare E"'

4. Learning Interpretable Regularized Ordinal Models from 3D Mesh Data for Neurodegenerative Disease Staging

Author

for the ENIGMA consortium, Zhao, Yuji, Laansma, Max A., van Heese, Eva M., Owens-Walton, Conor, Parkes, Laura M., Debove, Ines, Rummel, Christian, Wiest, Roland, Cendes, Fernando, Guimaraes, Rachel, Yasuda, Clarissa Lin, Wang, Jiun-Jie, Anderson, Tim J., Dalrymple-Alford, John C., Melzer, Tracy R., Pitcher, Toni L., Schmidt, Reinhold, Schwingenschuh, Petra, Garraux, Gäetan, Rango, Mario, Squarcina, Letizia, Al-Bachari, Sarah, Emsley, Hedley C. A., Klein, Johannes C., Mackay, Clare E., Dirkx, Michiel F., Helmich, Rick, Assogna, Francesca, Piras, Fabrizio, Bright, Joanna K., Spalletta, Gianfranco, Poston, Kathleen, Lochner, Christine, McMillan, Corey T., Weintraub, Daniel, Druzgal, Jason, Newman, Benjamin, Van Den Heuvel, Odile A., Jahanshad, Neda, Thompson, Paul M., van der Werf, Ysbrand D., Gutman, Boris, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Abdulkadir, Ahmed, editor, Bathula, Deepti R., editor, Dvornek, Nicha C., editor, Habes, Mohamad, editor, Kia, Seyed Mostafa, editor, Kumar, Vinod, editor, and Wolfers, Thomas, editor

Published
2022
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7. Author Correction: Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations

Author

Vignando, Miriam, ffytche, Dominic, Lewis, Simon J. G., Lee, Phil Hyu, Chung, Seok Jong, Weil, Rimona S., Hu, Michele T., Mackay, Clare E., Griffanti, Ludovica, Pins, Delphine, Dujardin, Kathy, Jardri, Renaud, Taylor, John-Paul, Firbank, Michael, McAlonan, Grainne, Mak, Henry K. F., Ho, Shu Leong, and Mehta, Mitul A.

Published
2022
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10. Integrating large-scale neuroimaging research datasets: Harmonisation of white matter hyperintensity measurements across Whitehall and UK Biobank datasets

Author

Bordin, Valentina, Bertani, Ilaria, Mattioli, Irene, Sundaresan, Vaanathi, McCarthy, Paul, Suri, Sana, Zsoldos, Enikő, Filippini, Nicola, Mahmood, Abda, Melazzini, Luca, Laganà, Maria Marcella, Zamboni, Giovanna, Singh-Manoux, Archana, Kivimäki, Mika, Ebmeier, Klaus P, Baselli, Giuseppe, Jenkinson, Mark, Mackay, Clare E, Duff, Eugene P, and Griffanti, Ludovica

Published
2021
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20. Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging

Author

Delgado-Goni, Teresa, primary, Connor-Robson, Natalie, additional, Cioroch, Milena, additional, Paisey, Stephen, additional, Marshall, Christopher, additional, Lane, Emma L, additional, Hauton, David, additional, McCullagh, James, additional, Magill, Peter J, additional, Cragg, Stephanie J, additional, Mackay, Clare E, additional, Wade-Martins, Richard, additional, and Klein, Johannes C, additional

Published
2023
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21. Oxford brain health clinic: protocol and research database

Author

O'Donoghue, Melissa Clare, primary, Blane, Jasmine, additional, Gillis, Grace, additional, Mitchell, Robert, additional, Lindsay, Karen, additional, Semple, Juliet, additional, Pretorius, Pieter M, additional, Griffanti, Ludovica, additional, Fossey, Jane, additional, Raymont, Vanessa, additional, Martos, Lola, additional, and Mackay, Clare E, additional

Published
2023
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23. Iterative Dual LDA: A Novel Classification Algorithm for Resting State fMRI

Author

Arya, Zobair, Griffanti, Ludovica, Mackay, Clare E., Jenkinson, Mark, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Wang, Li, editor, Adeli, Ehsan, editor, Wang, Qian, editor, Shi, Yinghuan, editor, and Suk, Heung-Il, editor

Published
2016
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29. Associations between arterial stiffening and brain structure, perfusion, and cognition in the Whitehall II Imaging Sub-study: A retrospective cohort study

Author

Suri, Sana, Chiesa, Scott T., Zsoldos, Eniko, Mackay, Clare E., Filippini, Nicola, Griffanti, Ludovica, Mahmood, Abda, Singh-Manoux, Archana, Shipley, Martin J., Brunner, Eric J., Kivimäki, Mika, Deanfield, John E., and Ebmeier, Klaus P.

Subjects
Aging -- Health aspects -- Physiological aspects, Cerebral circulation -- Health aspects, Cognition disorders -- Risk factors, Vascular resistance -- Health aspects, Biological sciences
Abstract

Background Aortic stiffness is closely linked with cardiovascular diseases (CVDs), but recent studies suggest that it is also a risk factor for cognitive decline and dementia. However, the brain changes underlying this risk are unclear. We examined whether aortic stiffening during a 4-year follow-up in mid-to-late life was associated with brain structure and cognition in the Whitehall II Imaging Sub-study. Methods and findings The Whitehall II Imaging cohort is a randomly selected subset of the ongoing Whitehall II Study, for which participants have received clinical follow-ups for 30 years, across 12 phases. Aortic pulse wave velocity (PWV) was measured in 2007-2009 (Phase 9) and at a 4-year follow-up in 2012-2013 (Phase 11). Between 2012 and 2016 (Imaging Phase), participants received a multimodal 3T brain magnetic resonance imaging (MRI) scan and cognitive tests. Participants were selected if they had no clinical diagnosis of dementia and no gross brain structural abnormalities. Voxel-based analyses were used to assess grey matter (GM) volume, white matter (WM) microstructure (fractional anisotropy (FA) and diffusivity), white matter lesions (WMLs), and cerebral blood flow (CBF). Cognitive outcomes were performance on verbal memory, semantic fluency, working memory, and executive function tests. Of 542 participants, 444 (81.9%) were men. The mean (SD) age was 63.9 (5.2) years at the baseline Phase 9 examination, 68.0 (5.2) at Phase 11, and 69.8 (5.2) at the Imaging Phase. Voxel-based analysis revealed that faster rates of aortic stiffening in mid-to-late life were associated with poor WM microstructure, viz. lower FA, higher mean, and radial diffusivity (RD) in 23.9%, 11.8%, and 22.2% of WM tracts, respectively, including the corpus callosum, corona radiata, superior longitudinal fasciculus, and corticospinal tracts. Similar voxel-wise associations were also observed with follow-up aortic stiffness. Moreover, lower mean global FA was associated with faster rates of aortic stiffening (B = -5.65, 95% CI -9.75, -1.54, Bonferroni-corrected p < 0.0125) and higher follow-up aortic stiffness (B = -1.12, 95% CI -1.95, -0.29, Bonferroni-corrected p < 0.0125). In a subset of 112 participants who received arterial spin labelling scans, faster aortic stiffening was also related to lower cerebral perfusion in 18.4% of GM, with associations surviving Bonferroni corrections in the frontal (B = -10.85, 95% CI -17.91, -3.79, p < 0.0125) and parietal lobes (B = -12.75, 95% CI -21.58, -3.91, p < 0.0125). No associations with GM volume or WMLs were observed. Further, higher baseline aortic stiffness was associated with poor semantic fluency (B = -0.47, 95% CI -0.76 to -0.18, Bonferroni-corrected p < 0.007) and verbal learning outcomes (B = -0.36, 95% CI -0.60 to -0.12, Bonferroni-corrected p < 0.007). As with all observational studies, it was not possible to infer causal associations. The generalisability of the findings may be limited by the gender imbalance, high educational attainment, survival bias, and lack of ethnic and socioeconomic diversity in this cohort. Conclusions Our findings indicate that faster rates of aortic stiffening in mid-to-late life were associated with poor brain WM microstructural integrity and reduced cerebral perfusion, likely due to increased transmission of pulsatile energy to the delicate cerebral microvasculature. Strategies to prevent arterial stiffening prior to this point may be required to offer cognitive benefit in older age. Trial registration ClinicalTrials.gov NCT03335696, Author(s): Sana Suri 1,2,*, Scott T. Chiesa 3, Eniko Zsoldos 1,2, Clare E. Mackay 1,2, Nicola Filippini 1,2, Ludovica Griffanti 1,2, Abda Mahmood 1, Archana Singh-Manoux 4,5, Martin J. Shipley [...]

Published
2020
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31. Adapting UK Biobank imaging for use in a routine memory clinic setting: the Oxford Brain Health Clinic

Author

Griffanti, Ludovica, primary, Gillis, Grace, additional, O’Donoghue, M. Clare, additional, Blane, Jasmine, additional, Pretorius, Pieter M., additional, Mitchell, Robert, additional, Aikin, Nicola, additional, Lindsay, Karen, additional, Campbell, Jon, additional, Semple, Juliet, additional, Alfaro-Almagro, Fidel, additional, Smith, Stephen M., additional, Miller, Karla L., additional, Martos, Lola, additional, Raymont, Vanessa, additional, and Mackay, Clare E., additional

Published
2022
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43. Learning Interpretable Regularized Ordinal Models from 3D Mesh Data for Neurodegenerative Disease Staging

Author

Zhao, Yuji, Laansma, Max A., van Heese, Eva M., Owens-Walton, Conor, Parkes, Laura M., Debove, Ines, Rummel, Christian, Wiest, Roland, Cendes, Fernando, Guimaraes, Rachel, Yasuda, Clarissa Lin, Wang, Jiun-Jie, Anderson, Tim J., Dalrymple-Alford, John C., Melzer, Tracy R., Pitcher, Toni L., Schmidt, Reinhold, Schwingenschuh, Petra, Garraux, Gäetan, Rango, Mario, Squarcina, Letizia, Al-Bachari, Sarah, Emsley, Hedley C. A., Klein, Johannes C., Mackay, Clare E., Dirkx, Michiel F., Helmich, Rick, Assogna, Francesca, Piras, Fabrizio, Bright, Joanna K., Spalletta, Gianfranco, Poston, Kathleen, Lochner, Christine, McMillan, Corey T., Weintraub, Daniel, Druzgal, Jason, Newman, Benjamin, Van Den Heuvel, Odile A., Jahanshad, Neda, Thompson, Paul M., van der Werf, Ysbrand D., and Gutman, Boris

Subjects
610 Medicine & health
Published
2022
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