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1. MyD88 and TLR4 Expression in Epithelial Ovarian Cancer.

Author

Block, Matthew S, Vierkant, Robert A, Rambau, Peter F, Winham, Stacey J, Wagner, Philipp, Traficante, Nadia, Tołoczko, Aleksandra, Tiezzi, Daniel G, Taran, Florin Andrei, Sinn, Peter, Sieh, Weiva, Sharma, Raghwa, Rothstein, Joseph H, Ramón Y Cajal, Teresa, Paz-Ares, Luis, Oszurek, Oleg, Orsulic, Sandra, Ness, Roberta B, Nelson, Gregg, Modugno, Francesmary, Menkiszak, Janusz, McGuire, Valerie, McCauley, Bryan M, Mack, Marie, Lubiński, Jan, Longacre, Teri A, Li, Zheng, Lester, Jenny, Kennedy, Catherine J, Kalli, Kimberly R, Jung, Audrey Y, Johnatty, Sharon E, Jimenez-Linan, Mercedes, Jensen, Allan, Intermaggio, Maria P, Hung, Jillian, Herpel, Esther, Hernandez, Brenda Y, Hartkopf, Andreas D, Harnett, Paul R, Ghatage, Prafull, García-Bueno, José M, Gao, Bo, Fereday, Sian, Eilber, Ursula, Edwards, Robert P, de Sousa, Christiani B, de Andrade, Jurandyr M, Chudecka-Głaz, Anita, Chenevix-Trench, Georgia, Cazorla, Alicia, Brucker, Sara Y, Australian Ovarian Cancer Study Group, Alsop, Jennifer, Whittemore, Alice S, Steed, Helen, Staebler, Annette, Moysich, Kirsten B, Menon, Usha, Koziak, Jennifer M, Kommoss, Stefan, Kjaer, Susanne K, Kelemen, Linda E, Karlan, Beth Y, Huntsman, David G, Høgdall, Estrid, Gronwald, Jacek, Goodman, Marc T, Gilks, Blake, García, María José, Fasching, Peter A, de Fazio, Anna, Deen, Suha, Chang-Claude, Jenny, Candido Dos Reis, Francisco J, Campbell, Ian G, Brenton, James D, Bowtell, David D, Benítez, Javier, Pharoah, Paul DP, Köbel, Martin, Ramus, Susan J, and Goode, Ellen L

Subjects
Australian Ovarian Cancer Study Group, Humans, Ovarian Neoplasms, Tissue Array Analysis, Immunohistochemistry, Survival Analysis, Adult, Aged, Middle Aged, Female, Toll-Like Receptor 4, Myeloid Differentiation Factor 88, Biomarkers, Tumor, Carcinoma, Ovarian Epithelial, Biomarkers, Tumor, Carcinoma, Ovarian Epithelial, Medical and Health Sciences
Abstract

ObjectiveTo evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival.Patients and methodsWe conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong).ResultsExpression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P

Published
2018

4. Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study

Author

Sieh, Weiva, Köbel, Martin, Longacre, Teri A, Bowtell, David D, deFazio, Anna, Goodman, Marc T, Høgdall, Estrid, Deen, Suha, Wentzensen, Nicolas, Moysich, Kirsten B, Brenton, James D, Clarke, Blaise A, Menon, Usha, Gilks, C Blake, Kim, Andre, Madore, Jason, Fereday, Sian, George, Joshy, Galletta, Laura, Lurie, Galina, Wilkens, Lynne R, Carney, Michael E, Thompson, Pamela J, Matsuno, Rayna K, Kjær, Susanne Krüger, Jensen, Allan, Høgdall, Claus, Kalli, Kimberly R, Fridley, Brooke L, Keeney, Gary L, Vierkant, Robert A, Cunningham, Julie M, Brinton, Louise A, Yang, Hannah P, Sherman, Mark E, García-Closas, Montserrat, Lissowska, Jolanta, Odunsi, Kunle, Morrison, Carl, Lele, Shashikant, Bshara, Wiam, Sucheston, Lara, Jimenez-Linan, Mercedes, Driver, Kristy, Alsop, Jennifer, Mack, Marie, McGuire, Valerie, Rothstein, Joseph H, Rosen, Barry P, Bernardini, Marcus Q, Mackay, Helen, Oza, Amit, Wozniak, Eva L, Benjamin, Elizabeth, Gentry-Maharaj, Aleksandra, Gayther, Simon A, Tinker, Anna V, Prentice, Leah M, Chow, Christine, Anglesio, Michael S, Johnatty, Sharon E, Chenevix-Trench, Georgia, Whittemore, Alice S, Pharoah, Paul DP, Goode, Ellen L, Huntsman, David G, and Ramus, Susan J

Published
2013
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9. Psychocutaneous disorders: how to recognize - and help - patients with self-inflicted skin injury

Author

Mack, Marie F., Orengo, Ida, and Rosen, Ted

Subjects
Skin diseases -- Diagnosis, Psychophysiologic disorders -- Care and treatment
Abstract

Psychological problems are often manifested in the skin. Many patients with psychocutaneous disorders, which are direct evidence of or secondary to psychological aberrations, drift from physician to physician, trying to […]

Published
1996

10. Von der Kompetenz zur Note im Sportunterricht. Eine kompetenzorientierte Unterrichtsreihe zum Thema Orientierungslauf für eine 3. Klasse

Author

Mack, Marie, Wittenwiler, Desirée, Mack, Marie, and Wittenwiler, Desirée

Abstract

Der vorliegenden Bachelorarbeit liegt die Idee zugrunde, das Thema Orientierungslauf in der Primarschule anhand des neuen Lehrplanes Volksschule aufzugreifen. Mittels Literaturrecherche und Übungsbeispielen wurde eine Unterrichtsreihe inklusive summative Überprüfung für Lehrpersonen entwickelt. In dieser Bachelorarbeit wurde die Frage: «Welche Faktoren sind für eine kompetenzorientierte Notengebung im Fachbereich Bewegung und Sport bestimmend?» bearbeitet. Bei der thematischen Auseinandersetzung war den Studierenden, Marie Mack und Desirée Wittenwiler, wichtig herauszufinden, wie eine kompetenzorientierte Unterrichtsreihe aufgebaut werden muss, damit sie durchführbar ist und am Ende auch summativ überprüft werden kann. Dies konnte mit der Unterstützung von drei Lehrpersonen, welche jeweils die Unterrichtsreihen durchgeführt haben, erfolgen. Beginnend mit der Erstellung der Unterrichtsreihe und der Recherche von Theorien sowie der Zusammenarbeit mit den Lehrpersonen konnte parallel ein Theorie-PraxisBezug hergestellt werden, welcher laufend angepasst wurde. Für die praktische Durchführung wurde ein Unterrichtsarrangement entwickelt, welches sich in Zukunft zu Wiederverwendungszwecken eignet. In der vorliegenden Bachelorarbeit wird der Umgang, sowie die Durchführung eines kompetenzorientierten Unterrichts anhand des Lehrplan Volksschule aufgezeigt und anhand von den Durchführungen der Lehrpersonen optimiert und angepasst.

Published
2018

11. Psychocutaneous disorders: a photo essay

Author

Mack, Marie F., Orengo, Ida, and Rosen, Ted

Subjects
Medical research, Medicine, Experimental, Skin diseases, Health, Psychology and mental health
Abstract

Psychological problems are often manifest in the skin. In fact, it is estimated that between 20% and 30% of all skin disorders have some psychological component. Many patients who have [...]

Published
2009

13. Readers Report.

Author

Crowder, Tinsley, Mack, Marie E., Koten, John A., Gonsion, Marwin H., Barrett, George B., Papier, William, Short, Daniel G., Nelson, Robin C., Aks, Daniel E., Peters, Ralph F., and Thornburg Jr., H. Garrett

Subjects
LETTERS to the editor, AT&T computers, STOCK exchanges, FINANCIAL crises, MONEY market
Abstract

Several letters to the editor are presented in response to articles in previous issues including "AT&T: The Making of a Comeback," in the January 18, 1988 issue, "What's Missing From Brady's Postmortem," in the January 25, 1988 issue, and "Howard Rubin's Resume Didn't Faze Bear Stearns," in the January 11, 1988 issue.

Published
1988

14. Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier

Author

Martins, Filipe C, primary, Santiago, Ines de, additional, Trinh, Anne, additional, Xian, Jian, additional, Guo, Anne, additional, Sayal, Karen, additional, Jimenez-Linan, Mercedes, additional, Deen, Suha, additional, Driver, Kristy, additional, Mack, Marie, additional, Aslop, Jennifer, additional, Pharoah, Paul D, additional, Markowetz, Florian, additional, and Brenton, James D, additional

Published
2014
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15. Hormone-receptor expression and ovarian cancer survival:an Ovarian Tumor Tissue Analysis consortium study

Author

Sieh, Weiva, Köbel, Martin, Longacre, Teri A, Bowtell, David D, deFazio, Anna, Goodman, Marc T, Høgdall, Estrid, Deen, Suha, Wentzensen, Nicolas, Moysich, Kirsten B, Brenton, James D, Clarke, Blaise A, Menon, Usha, Gilks, C Blake, Kim, Andre, Madore, Jason, Fereday, Sian, George, Joshy, Galletta, Laura, Lurie, Galina, Wilkens, Lynne R, Carney, Michael E, Thompson, Pamela J, Matsuno, Rayna K, Kjær, Susanne Krüger, Jensen, Allan, Høgdall, Claus, Kalli, Kimberly R, Fridley, Brooke L, Keeney, Gary L, Vierkant, Robert A, Cunningham, Julie M, Brinton, Louise A, Yang, Hannah P, Sherman, Mark E, García-Closas, Montserrat, Lissowska, Jolanta, Odunsi, Kunle, Morrison, Carl, Lele, Shashikant, Bshara, Wiam, Sucheston, Lara, Jimenez-Linan, Mercedes, Driver, Kristy, Alsop, Jennifer, Mack, Marie, McGuire, Valerie, Rothstein, Joseph H, Rosen, Barry P, Bernardini, Marcus Q, Mackay, Helen, Oza, Amit, Wozniak, Eva L, Benjamin, Elizabeth, Gentry-Maharaj, Aleksandra, Gayther, Simon A, Tinker, Anna V, Prentice, Leah M, Chow, Christine, Anglesio, Michael S, Johnatty, Sharon E, Chenevix-Trench, Georgia, Whittemore, Alice S, Pharoah, Paul D P, Goode, Ellen L, Huntsman, David G, Ramus, Susan J, Sieh, Weiva, Köbel, Martin, Longacre, Teri A, Bowtell, David D, deFazio, Anna, Goodman, Marc T, Høgdall, Estrid, Deen, Suha, Wentzensen, Nicolas, Moysich, Kirsten B, Brenton, James D, Clarke, Blaise A, Menon, Usha, Gilks, C Blake, Kim, Andre, Madore, Jason, Fereday, Sian, George, Joshy, Galletta, Laura, Lurie, Galina, Wilkens, Lynne R, Carney, Michael E, Thompson, Pamela J, Matsuno, Rayna K, Kjær, Susanne Krüger, Jensen, Allan, Høgdall, Claus, Kalli, Kimberly R, Fridley, Brooke L, Keeney, Gary L, Vierkant, Robert A, Cunningham, Julie M, Brinton, Louise A, Yang, Hannah P, Sherman, Mark E, García-Closas, Montserrat, Lissowska, Jolanta, Odunsi, Kunle, Morrison, Carl, Lele, Shashikant, Bshara, Wiam, Sucheston, Lara, Jimenez-Linan, Mercedes, Driver, Kristy, Alsop, Jennifer, Mack, Marie, McGuire, Valerie, Rothstein, Joseph H, Rosen, Barry P, Bernardini, Marcus Q, Mackay, Helen, Oza, Amit, Wozniak, Eva L, Benjamin, Elizabeth, Gentry-Maharaj, Aleksandra, Gayther, Simon A, Tinker, Anna V, Prentice, Leah M, Chow, Christine, Anglesio, Michael S, Johnatty, Sharon E, Chenevix-Trench, Georgia, Whittemore, Alice S, Pharoah, Paul D P, Goode, Ellen L, Huntsman, David G, and Ramus, Susan J

Published
2013

17. MyD88 and TLR4 Expression in Epithelial Ovarian Cancer

Author

Block, Matthew S, Vierkant, Robert A, Rambau, Peter F, Winham, Stacey J, Wagner, Philipp, Traficante, Nadia, Tołoczko, Aleksandra, Tiezzi, Daniel G, Taran, Florin Andrei, Sinn, Peter, Sieh, Weiva, Sharma, Raghwa, Rothstein, Joseph H, Ramón Y Cajal, Teresa, Paz-Ares, Luis, Oszurek, Oleg, Orsulic, Sandra, Ness, Roberta B, Nelson, Gregg, Modugno, Francesmary, Menkiszak, Janusz, McGuire, Valerie, McCauley, Bryan M, Mack, Marie, Lubiński, Jan, Longacre, Teri A, Li, Zheng, Lester, Jenny, Kennedy, Catherine J, Kalli, Kimberly R, Jung, Audrey Y, Johnatty, Sharon E, Jimenez-Linan, Mercedes, Jensen, Allan, Intermaggio, Maria P, Hung, Jillian, Herpel, Esther, Hernandez, Brenda Y, Hartkopf, Andreas D, Harnett, Paul R, Ghatage, Prafull, García-Bueno, José M, Gao, Bo, Fereday, Sian, Eilber, Ursula, Edwards, Robert P, De Sousa, Christiani B, De Andrade, Jurandyr M, Chudecka-Głaz, Anita, Chenevix-Trench, Georgia, Cazorla, Alicia, Brucker, Sara Y, Australian Ovarian Cancer Study Group, Alsop, Jennifer, Whittemore, Alice S, Steed, Helen, Staebler, Annette, Moysich, Kirsten B, Menon, Usha, Koziak, Jennifer M, Kommoss, Stefan, Kjaer, Susanne K, Kelemen, Linda E, Karlan, Beth Y, Huntsman, David G, Høgdall, Estrid, Gronwald, Jacek, Goodman, Marc T, Gilks, Blake, García, María José, Fasching, Peter A, De Fazio, Anna, Deen, Suha, Chang-Claude, Jenny, Candido Dos Reis, Francisco J, Campbell, Ian G, Brenton, James D, Bowtell, David D, Benítez, Javier, Pharoah, Paul DP, Köbel, Martin, Ramus, Susan J, and Goode, Ellen L

Subjects
Adult, Ovarian Neoplasms, Carcinoma, Ovarian Epithelial, Middle Aged, Immunohistochemistry, Survival Analysis, 3. Good health, Toll-Like Receptor 4, Tissue Array Analysis, Myeloid Differentiation Factor 88, Biomarkers, Tumor, Humans, Female, Aged
Abstract

OBJECTIVE: To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. PATIENTS AND METHODS: We conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong). RESULTS: Expression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P

18. Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier

Author

Martins, Filipe C, Santiago, Ines de, Trinh, Anne, Xian, Jian, Guo, Anne, Sayal, Karen, Jimenez-Linan, Mercedes, Deen, Suha, Driver, Kristy, Mack, Marie, Aslop, Jennifer, Pharoah, Paul D, Markowetz, Florian, Brenton, James D, Pharoah, Paul [0000-0001-8494-732X], Markowetz, Florian [0000-0002-2784-5308], Brenton, James [0000-0002-5738-6683], and Apollo - University of Cambridge Repository

Subjects
Ovarian Neoplasms, Research, PTEN Phosphohydrolase, Genomics, Carcinoma, Ovarian Epithelial, Middle Aged, Prognosis, Cystadenocarcinoma, Serous, Gene Expression Regulation, Neoplastic, Receptors, Androgen, Tissue Array Analysis, Cell Line, Tumor, Humans, Female, Neoplasms, Glandular and Epithelial, Aged, Cell Proliferation
Abstract

Background TP53 and BRCA1/2 mutations are the main drivers in high-grade serous ovarian carcinoma (HGSOC). We hypothesise that combining tissue phenotypes from image analysis of tumour sections with genomic profiles could reveal other significant driver events. Results Automatic estimates of stromal content combined with genomic analysis of TCGA HGSOC tumours show that stroma strongly biases estimates of PTEN expression. Tumour-specific PTEN expression was tested in two independent cohorts using tissue microarrays containing 521 cases of HGSOC. PTEN loss or downregulation occurred in 77% of the first cohort by immunofluorescence and 52% of the validation group by immunohistochemistry, and is associated with worse survival in a multivariate Cox-regression model adjusted for study site, age, stage and grade. Reanalysis of TCGA data shows that hemizygous loss of PTEN is common (36%) and expression of PTEN and expression of androgen receptor are positively associated. Low androgen receptor expression was associated with reduced survival in data from TCGA and immunohistochemical analysis of the first cohort. Conclusion PTEN loss is a common event in HGSOC and defines a subgroup with significantly worse prognosis, suggesting the rational use of drugs to target PI3K and androgen receptor pathways for HGSOC. This work shows that integrative approaches combining tissue phenotypes from images with genomic analysis can resolve confounding effects of tissue heterogeneity and should be used to identify new drivers in other cancers. Electronic supplementary material The online version of this article (doi:10.1186/s13059-014-0526-8) contains supplementary material, which is available to authorized users.

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19. Recursive Partitioning Analysis for Local Control Achieved With Stereotactic Body Radiation Therapy for the Liver, Spine, or Lymph Nodes.

Author

Kowalchuk RO, Waters MR, Dutta SW, Mack ML, Richardson KM, Spencer K, Romano KD, Larner JM, Sheehan JP, and Kersh CR

Abstract

Purpose: This study aims to develop a local control risk stratification using recursive partitioning analysis (RPA) for patients receiving stereotactic body radiation therapy (SBRT) for metastatic cancer., Methods and Materials: A single institutional database of 397 SBRT treatments to the liver, spine, and lymph nodes was constructed. All treatments required imaging follow-up to assess for local control. Cox proportional hazards analysis was implemented before the decision tree analysis. The data were split into training (70%), validation (10%), and testing (20%) sets for RPA to optimize the training set., Results: In the study, 361 treatments were included in the local control analysis. Two-year local control was 71%. A decision tree analysis was used and the resulting model demonstrated 93.10% fidelity for the validation set and 87.67% for the test set. RPA class 3 was composed of patients with non-small cell lung cancer (NSCLC) primary tumors and treatment targets other than the cervical, thoracic, and lumbar spines. RPA class 2 included patients with primary cancers other than NSCLC or breast and treatments targets of the sacral spine or liver. RPA class 1 consisted of all other patients (including lymph node targets and patients with primary breast cancer). Classes 3, 2, and 1 demonstrated 3-year local controls rates of 29%, 50%, and 83%, respectively. On subgroup analysis using the Kaplan-Meier method, treatments for lymph nodes and primary ovarian disease demonstrated improved local control relative to other treatment targets ( P < .005) and primary disease sites ( P < .005), respectively., Conclusions: A local control risk stratification model for SBRT to sites of metastatic disease was developed. Treatment target and primary tumor were identified as critical factors determining local control. NSCLC primary lesions have increased local failure for targets other than the cervical, thoracic, or lumbar spines, and improved local control was identified for lymph node sites and breast or ovarian primary tumors., (© 2020 The Authors.)

Published
2020
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