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271 results on '"Maciejewski, Adam"'

1. VCA in Head and Neck Region

Author

Maciejewski, Adam, Krakowczyk, Łukasz, Bula, Daniel, Opyrchał, Jakub, Gurunian, Raffi, editor, Rampazzo, Antonio, editor, Papay, Frank, editor, and Bassiri Gharb, Bahar, editor

Published
2023
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10. Serum β-hCG as a Biomarker in Pancreatic Neuroendocrine Tumors: Rethinking Single-Analyte Approach.

Author

Komarnicki, Paweł, Gut, Paweł, Cieślewicz, Maja, Musiałkiewicz, Jan, Maciejewski, Adam, Czupińska, Michalina, Mastorakos, George, and Ruchała, Marek

Subjects
REPEATED measures design, RESEARCH funding, QUESTIONNAIRES, TUMOR markers, CANCER patients, TUMOR grading, DESCRIPTIVE statistics, PANCREATIC tumors, CHORIONIC gonadotropins, NEUROENDOCRINE tumors
Abstract

Simple Summary: The lack of biomarkers in neuroendocrine tumors (NETs) represents a critical unmet need. Conventional single analytes lack the required diagnostic accuracy. Multianalyte assays (e.g., NETest) offer improved performance but remain costly and largely unavailable. In our study, serum beta-human chorionic gonadotropin (β-hCG) shows promise as a biomarker in metastatic pancreatic NETs. β-hCG concentrations strongly correlate with established indicators of aggressive tumor behavior, including progressive disease, per RECIST; greater liver tumor burden; and higher WHO tumor grade. Throughout the study period, β-hCG levels increased consistently, with sharper rises noted in more aggressive tumors. As a widely available and inexpensive assay, serum β-hCG emerges as a useful tool for the evaluation of treatment response and disease monitoring in pancreatic NETs, especially in the transitional period until multianalyte assays become a mainstay in scientific guidelines. Despite recent advances, neuroendocrine tumors (NETs) remain a challenging topic, due to their diversity and the lack of suitable biomarkers. Multianalyte assays and the shift to an omics-based approach improve on the conventional single-analyte strategy, albeit with their own drawbacks. We explored the potential of serum β-hCG as a biomarker for NETs and discussed its role in disease monitoring. We recruited 40 patients with non-functioning pancreatic NETs, all with liver metastases. Serum β-hCG concentrations were measured at 3-month intervals over 48 months. We performed a comparative and a repeated measures analysis of β-hCG depending on WHO grade (G1, G2), liver tumor burden (LTB; below 10%, 10–25%), and RECIST 1.1. (stable disease, progressive disease). Patients with progressive disease (p < 0.001), 10–25% LTB (p < 0.001) and WHO Grade 2 (p < 0.001) displayed higher β-hCG concentrations. Throughout the study, β-hCG concentrations consistently increased across the entire cohort. Delta β-hCG during the study period was greater in patients with 10–25% LTB (p < 0.001), progressive disease (p < 0.001), and G2 (p = 0.003). Serum β-hCG correlates with established indicators of malignancy and disease progression in metastatic NETs, supporting further studies as a monitoring and prognostic biomarker. Despite promising results from novel biomarkers, there is still a place for single-analyte assays in NETs. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Remote measurements of volcanic gases : applications of open-path Fourier transform infra-red spectroscopy (OP-FTIR) and Correlation spectroscopy (COSPEC)

Author

Maciejewski, Adam John Henry

Subjects
551.21, Volcanic gas plumes
Abstract

The composition of volcanic gas plumes depends largely on the chemistry of the degassing magma, the depth of volatile exsolution, and the level of volcanic activity. The ratios between the most common volcanic gases: C02, H2O, SO2, HCl and HF, as measured at the surface, can be used to provide information on the evolution of the magma body. My research on volcanic gases has centred on the use of open-path Fourier transform IR spectroscopy (Op_FTTR) and correlation spectroscopy (COSPEC). I have also used data collected using other direct and remote-sensing techniques. Remote-sensing techniques rely on the characteristic IR or UV absorbances of natural and/or artificial radiation by different gases. The longer range of these techniques enables the analysis of gases in inaccessible plumes; thus reducing the need for operators to enter hazardous areas. As the instruments do not interact with the analysed gases there is no contamination, condensation or secondary reactions. However, the instruments tend to be heavy, expensive, and complex. Environmental factors can complicate analyses; clouds can dissolve and remove analyte rapidly, and variations in wind speed can result in gas fluxes having high errors. It is also much more difficult to analyse specific gas sources remotely as mixing of gases from different sources can occur. Direct-sampling techniques rely on gases being trapped, dissolved or adsorbed before being analysed by traditional methods, e. g. wet-chemistry, colourimetry, and gas chromatography. The capture of gases is best achieved as close to the source as possible, thus increasing the risk to the operator, and may only be possible during periods of low activity. The physical interaction of gases with instrument and collection vessels can lead to contamination and initiation of secondary reactions. Direct-sampling techniques are labour intensive and thus are capable of only generating a relatively small amount of data compared to the more automated remote-sensing techniques. The suitability of an individual technique therefore depends greatly on: the type of gas to be measured; the location of vent or fumamle; the level of volcanic activity; and the environment in which data are collected. I used OP-FrIR on La Fossa di Vulcano to measure the S02: HCI mass ratios of gases emitted from the rim and central crater fumaroles, -4.3 - 6.1 and 0.9 - 2.6 respectively. I attributed the higher crater rim gas ratios to the interaction of the gases with shallow hydrothermal reservoirs, causing scrubbing of the more soluble HCl- At Mt. Etna, my OP-FTIR analysis of gases emitted from the central craters showed that, in 1994, S02: HC1 mass ratios were -4.9 - 5.8. These values lie between those reported for eruptive degassing, >10, and background degassing, < I, and probably relate to refilling of the magma system prior to the 1997 eruption. A comparative study of lava effusion rates and COSPEC-derived SO2 fluxes for the 1991 - 1993 Etna eruption showed that variations were generally synchronous; small scale differences relating to the drainage of degassed magma from beneath the summit craters into the eruptive fissure. I also conducted OP-FT'IR and COSPEC analyses on Montserrat in June 1996 to show the gas plume to be relatively S02 poor, with S02: HC1 mass ratios of < 0.5. The OP-FTIR technique enabled the first remote measurements of SiF4 in volcanic plumes to be made. I have also used HF-SiF4 ratios to estimate gas equilibrium temperatures at La Fossa and Mt. Etna to be --200°C and -250 - 290°C respectively. I have also investigated the structural evolution of the Masaya Volcanic Complex. The visible complex has formed over -1000 years; with average rates of effusion of -0.2 x 106 m3/y, much lower than those required to provide the estimated volume of caldera infill, -2 x 106 m3/y. Historic activity has centred on the twin massifs of Volcän Masaya and Volcän Santiago and is dominated by pit-crater collapses. I propose that the degassing episodes, which occur with no increase in eruptive activity, are related to the convective overturn of magma beneath the craters.

Published
1998
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28. Therapeutic Strategy in Low-Risk Papillary Thyroid Carcinoma – Long-Term Results of the First Single-Center Prospective Non-Randomized Trial Between 2011 and 2015

Author

Czarniecka, Agnieszka, primary, Zeman, Marcin, additional, Wozniak, Grzegorz, additional, Maciejewski, Adam, additional, Stobiecka, Ewa, additional, Chmielik, Ewa, additional, Oczko-Wojciechowska, Malgorzata, additional, Krajewska, Jolanta, additional, Handkiewicz-Junak, Daria, additional, and Jarzab, Barbara, additional

Published
2021
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34. DrugBank 4.0: shedding new light on drug metabolism

Author

Law, Vivian, Knox, Craig, Djoumbou, Yannick, Jewison, Tim, Guo, An Chi, Liu, Yifeng, Maciejewski, Adam, Arndt, David, Wilson, Michael, Neveu, Vanessa, Tang, Alexandra, Gabriel, Geraldine, Ly, Carol, Adamjee, Sakina, Dame, Zerihun T., Han, Beomsoo, Zhou, You, and Wishart, David S.

Published
2014
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35. SMPDB 2.0: Big Improvements to the Small Molecule Pathway Database

Author

Jewison, Timothy, Su, Yilu, Disfany, Fatemeh Miri, Liang, Yongjie, Knox, Craig, Maciejewski, Adam, Poelzer, Jenna, Huynh, Jessica, Zhou, You, Arndt, David, Djoumbou, Yannick, Liu, Yifeng, Deng, Lu, Guo, An Chi, Han, Beomsoo, Pon, Allison, Wilson, Michael, Rafatnia, Shahrzad, Liu, Philip, and Wishart, David S.

Published
2014
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37. Do surgeons use double gloves during surgery? Results of a survey

Author

Walczak, Dominik, primary, Grajek, Maciej, additional, Pawełczak, Dariusz, additional, Żółtaszek, Agata, additional, Szumniak, Ryszard, additional, Czarnecki, Marek, additional, Trzeciak, Piotr, additional, Krakowczyk, Łukasz, additional, Maciejewski, Adam, additional, and Pasieka, Zbigniew, additional

Published
2020
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