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3. Association of the miR-143 Gene rs353292 Polymorphism with Recurrent Pregnancy Loss in Caucasian Women: A Novel Finding in a Multifactorial Devastating Problem.

Author

Stavros, Sofoklis, Potiris, Anastasios, Christopoulos, Panagiotis, Zacharopoulou, Natalia, Kyrli, Vasiliki, Mavrogianni, Despoina, Zikopoulos, Athanasios, Drakaki, Eirini, Karampitsakos, Theodoros, Topis, Spyridon, Machairiotis, Nikolaos, Gerede, Angeliki, Skentou, Chara, Drakakis, Peter, and Domali, Ekaterini

Subjects
MISCARRIAGE, GENETIC polymorphisms, POLYMERASE chain reaction, POLYMORPHISM (Zoology), INFLAMMATION, RECURRENT miscarriage
Abstract

The purpose of this prospective case–control study is to investigate the correlation of the miR-143 gene rs353292 polymorphism in Caucasian women with recurrent pregnancy loss (RPL) compared to a matched control group with at least one live birth and without pregnancy losses. In total, 110 women with recurrent pregnancy losses and 95 control women were recruited. Peripheral blood was collected from all women, and the isolation of DNA was performed with Monarch Genomic DNA Purification. Polymerase chain reaction was applied to amplify the DNA sequence of the miR-143 gene promoter, carrying the polymorphism rs353292. The incidence of genotype CC in the RPL group was statistically significantly higher than in control group (p < 0.0001). Allele C (CT + CC) in the control group was found in 47.36%, and in the RPL group was found in 68.17% (p = 0.006). SNP rs353292 T>C was associated with increased risk of recurrent pregnancy loss. The calculated odds ratio for CT + CC vs. TT and for CC vs. TT were significant higher (p = 0.0028 and p < 0.0001, respectively). The study results suggest that the rs353292 polymorphism is associated with a statistically significant increase in RPL prevalence. The present study provides additional evidence in favor of a shared pathophysiological mechanism that contributes to both RPLs, potentially through inflammatory processes and epithelial–mesenchymal transition dysregulation. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Investigating the Imperative Role of microRNAs Expression in Human Embryo Implantation: A Narrative Review Based on Recent Evidence.

Author

Potiris, Anastasios, Stavros, Sofoklis, Zouganeli, Ioanna, Machairiotis, Nikolaos, Drakaki, Eirini, Zikopoulos, Athanasios, Anagnostaki, Ismini, Zachariou, Athanasios, Gerede, Angeliki, Domali, Ekaterini, and Drakakis, Peter

Subjects
HUMAN embryo transfer, EMBRYO implantation, GENE expression, NON-coding RNA, MICRORNA, ANIMAL reproduction
Abstract

Background/Objectives: Embryo implantation is a highly complex process that requires the precise regulation of numerous molecules to be orchestrated successfully. Micro RNAs (miRNAs) are small non-coding RNAs that regulate gene expression and play a crucial role in the regulation of embryo implantation. This article aims to summarize the key findings of the literature regarding the role of miRNAs in human embryo implantation, emphasizing their involvement in critical stages such as decidualization, endometrial receptivity and trophoblast adhesion. Methods: This review includes primary research articles from the past decade. The studies utilize a range of experimental methodologies, including gene expression analysis and in vitro studies. Results: MicroRNAs, like miR-320a, miR-149, and miR30d secreted by preimplantation embryos and blastocysts significantly influence endometrial receptivity by promoting essential cellular processes, such as cell migration and trophoblast cell attachment, while others—miR17-5p, miR-193-3p, miR-372, and miR-542-3p—secreted from the endometrium regulate the decidualization phase. During the apposition and adhesion phases, miRNAs play a complex role by promoting, for example, miR-23b-3p, and inhibiting—as do miR-29c and miR-519d-3p—important biological pathways of these stages. During invasion, miR-26a-5p and miR-125-5p modulate important genes. Conclusions: This review underscores the critical impact of miRNAs in the regulation of embryo implantation and early pregnancy. The ability of miRNAs to modulate gene expression at various stages of reproduction presents promising therapeutic avenues for improving assisted reproductive technologies outcomes and addressing infertility. Further research into miRNA-based diagnostic tools and therapeutic strategies is essential to enhance our understanding of their role in reproductive health and to exploit their potential for clinical applications. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Decoding Apelin: Its Role in Metabolic Programming, Fetal Growth, and Gestational Complications.

Author

Loukas, Nikolaos, Vrachnis, Dionysios, Antonakopoulos, Nikolaos, Stavros, Sofoklis, Machairiotis, Nikolaos, Fotiou, Alexandros, Christodoulaki, Chryssi, Lolos, Markos, Maroudias, Georgios, Potiris, Anastasios, Drakakis, Petros, and Vrachnis, Nikolaos

Subjects
GLUCOSE metabolism, RISK factors of preeclampsia, ADIPOKINES, SMALL for gestational age, FETAL growth retardation, OXIDATIVE stress, GENE expression, GROWTH factors, FETAL development, PREGNANCY complications, INFLAMMATION, PATHOLOGIC neovascularization, DISEASE risk factors
Abstract

Placental insufficiency and gestational diabetes, which are both serious pregnancy complications, are linked to altered fetal growth, whether restricted or excessive, and result in metabolic dysfunction, hypoxic/oxidative injury, and adverse perinatal outcomes. Although much research has been carried out in this field, the underlying pathogenetic mechanisms have not as yet been fully elucidated. Particularly because of the role it plays in cardiovascular performance, glucose metabolism, inflammation, and oxidative stress, the adipokine apelin was recently shown to be a potential regulator of fetal growth and metabolic programming. This review investigated the numerous biological actions of apelin in utero and aimed to shed more light on its role in fetal growth and metabolic programming. The expression of the apelinergic system in a number of tissues indicates its involvement in many physiological mechanisms, including angiogenesis, cell proliferation, energy metabolism, inflammation, and oxidative stress. Moreover, it appears that apelin has a major function in disorders such as diabetes mellitus, fetal growth abnormalities, fetal hypoxia, and preeclampsia. We herein describe in detail the regulatory effects exerted by the adipokine apelin on fetal growth and metabolic programming while stressing the necessity for additional research into the therapeutic potential of apelin and its mechanisms of action in pregnancy-related disorders. [ABSTRACT FROM AUTHOR]

Published
2024
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7. A Narrative Review on the Clinical Utility of Electrical Impedance Spectroscopy for Diagnosing High-Grade Cervical Intraepithelial Neoplasia

Author

Panagakis, Georgios P, primary, Machairiotis, Nikolaos, additional, Tsiriva, Maria, additional, Theofanakis, Charalampos, additional, Tsetsa, Paraskevi, additional, Pantelis, Athanasios G, additional, Thomakos, Nikolaos, additional, Rodolakis, Alexandros, additional, and Haidopoulos, Dimitrios, additional

Published
2024
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9. The Impact of Adenomyosis on Pregnancy.

Author

Tsikouras, Panagiotis, Kritsotaki, Nektaria, Nikolettos, Konstantinos, Kotanidou, Sonia, Oikonomou, Efthymios, Bothou, Anastasia, Andreou, Sotiris, Nalmpanti, Theopi, Chalkia, Kyriaki, Spanakis, Vlasios, Tsikouras, Nikolaos, Chalil, Melda, Machairiotis, Nikolaos, Iatrakis, George, and Nikolettos, Nikolaos

Subjects
LOW birth weight, PREGNANCY complications, PREMATURE labor, ECTOPIC tissue, ENDOCRINE system, PLACENTA praevia, UTERINE hemorrhage
Abstract

Adenomyosis is characterized by ectopic proliferation of endometrial tissue within the myometrium. Histologically, this condition is marked by the presence of islands of benign endometrial glands surrounded by stromal cells. The myometrium appears thinner, and cross-sectional analysis often reveals signs of recent or chronic hemorrhage. The ectopic endometrial tissue may respond to ovarian hormonal stimulation, exhibiting proliferative or secretory changes during the menstrual cycle, potentially leading to bleeding, uterine swelling, and pain. Adenomyosis can appear as either a diffuse or focal condition. It is crucial to understand that adenomyosis involves the infiltration of the endometrium into the myometrium, rather than its displacement. The surgical management of adenomyosis is contingent upon its anatomical extent. The high incidence of the disease and the myths that develop around it increase the need to study its characteristics and its association with pregnancy and potential obstetric complications. These complications often require quick decisions, appropriate diagnosis, and proper counseling. Therefore, knowing the possible risks associated with adenomyosis is key to decision making. Pregnancy has a positive effect on adenomyosis and its painful symptoms. This improvement is not only due to the inhibition of ovulation, which inhibits the bleeding of adenomyotic tissue, but also to the metabolic, hormonal, immunological, and angiogenic changes associated with pregnancy. Adenomyosis affects pregnancy through disturbances of the endocrine system and the body's immune response at both local and systemic levels. It leads to bleeding from the adenomyotic tissue, molecular and functional abnormalities of the ectopic endometrium, abnormal placentation, and destruction of the adenomyotic tissue due to changes in the hormonal environment that characterizes pregnancy. Some of the obstetric complications that occur in women with adenomyosis in pregnancy include miscarriage, preterm delivery, placenta previa, low birth weight for gestational age, obstetric hemorrhage, and the need for cesarean section. These complications are an understudied field and remain unknown to the majority of obstetricians. These pathological conditions pose challenges to both the typical progression of pregnancy and the smooth conduct of labor in affected women. Further multicenter studies are imperative to validate the most suitable method for concluding labor following surgical intervention for adenomyosis. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Measurement of Calprotectin and PTH in the Amniotic Fluid of Early Second Trimester Pregnancies and Their Impact on Fetuses with Growth Disorders: Are Their Levels Related to Oxidative Stress?

Author

Maroudias, George, primary, Vrachnis, Dionysios, additional, Fotiou, Alexandros, additional, Loukas, Nikolaos, additional, Mantzou, Aimilia, additional, Pergialiotis, Vasileiοs, additional, Valsamakis, George, additional, Machairiotis, Nikolaos, additional, Stavros, Sofoklis, additional, Panagopoulos, Periklis, additional, Vakas, Panagiotis, additional, Kanaka-Gantenbein, Christina, additional, Drakakis, Petros, additional, and Vrachnis, Nikolaos, additional

Published
2024
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12. Second Trimester Amniotic Fluid Angiotensinogen Levels Linked to Increased Fetal Birth Weight and Shorter Gestational Age in Term Pregnancies

Author

Vrachnis, Dionysios, primary, Fotiou, Alexandros, additional, Mantzou, Aimilia, additional, Pergialiotis, Vasilios, additional, Antsaklis, Panagiotis, additional, Valsamakis, George, additional, Stavros, Sofoklis, additional, Machairiotis, Nikolaos, additional, Iavazzo, Christos, additional, Kanaka-Gantenbein, Christina, additional, Mastorakos, George, additional, Drakakis, Petros, additional, Vrachnis, Nikolaos, additional, and Antonakopoulos, Nikolaos, additional

Published
2024
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13. Investigating the Association of Assisted Reproduction Techniques and Adverse Perinatal Outcomes

Author

Potiris, Anastasios, primary, Perros, Paraskevas, additional, Drakaki, Eirini, additional, Mavrogianni, Despoina, additional, Machairiotis, Nikolaos, additional, Sfakianakis, Antonios, additional, Karampitsakos, Theodoros, additional, Vrachnis, Dionysios, additional, Antonakopoulos, Nikolaos, additional, Panagopoulos, Periklis, additional, Drakakis, Peter, additional, and Stavros, Sofoklis, additional

Published
2024
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14. Thyroid disorders; an insidious cause leading to female infertility

Author

Potiris, Anastasios, primary, Machairiotis, Nikolaos, additional, Christidis, Ioannis, additional, Karampitsakos, Theodoros, additional, Variawa, Rita, additional, Drakaki, Eirini, additional, Mavrogianni, Despoina, additional, Panagopoulos, Periklis, additional, Domali, Ekaterini, additional, Drakakis, Peter, additional, and Stavros, Sofoklis, additional

Published
2024
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15. The Effectiveness of Metabolic Bariatric Surgery in Preventing Gynecologic Cancer - from Pathophysiology to Clinical Outcomes

Author

Machairiotis, Nikolaos, primary, Pantelis, Athanasios G., additional, Potiris, Anastasios, additional, Karampitsakos, Theodoros, additional, Drakakis, Petros, additional, Drakaki, Eirini, additional, Oikonomou, Panagoula, additional, Nikolaou, Christina, additional, Matthaios, Dimitrios, additional, Charalampidis, Charalampos, additional, Ioannidis, Aris, additional, Zarogoulidis, Paul, additional, and Sofoklis, Stavros, additional

Published
2024
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16. Simultaneous Resection for Colorectal and Liver Metastases, new equipment and personalized medicine

Author

Zarogoulidis, Paul, primary, Ioannidis, Aris, additional, Vagionas, Anastasios, additional, Perdikouri, Eleni Isidora, additional, Christakidis, Vagelis, additional, Anemoulis, Marios, additional, Kesisoglou, Isaak, additional, Matthaios, Dimitris, additional, Oikonomou, Panagoula, additional, Nikolaou, Christina, additional, Papalavrentios, Lavrentios, additional, Charalampidis, Charalampos, additional, Machairiotis, Nikolaos, additional, Papadopoulos, Vasilis, additional, and Sapalidis, Konstantinos, additional

Published
2024
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17. Ablation for Single Pulmonary Nodules, Primary or Metastatic. Εndobronchial Ablation Systems or Percutaneous

Author

Zarogoulidis, Paul, primary, Papadopoulos, Vasilis, additional, Perdikouri, Eleni-Isidora, additional, Vagionas, Anastasios, additional, Matthaios, Dimitris, additional, Ioannidis, Aris, additional, Hohemforst-Schmidt, Wolfgang, additional, Huang, Haidong, additional, Bai, Chong, additional, Panagoula, Oikonomou, additional, Nikolaou, Christina, additional, Charalampidis, Charalampos, additional, Kosmidis, Christoforos, additional, Sapalidis, Konstantinos, additional, Machairiotis, Nikolaos, additional, and Pataka, Athanasia, additional

Published
2024
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19. Association between COVID-19 Infection and Miscarriages, What We Really Know?

Author

Chrysanthopoulos, Ioannis, primary, Potiris, Anastasios, additional, Drakaki, Eirini, additional, Mavrogianni, Despoina, additional, Machairiotis, Nikolaos, additional, Zarogoulidis, Paul, additional, Karampitsakos, Theodoros, additional, Machairoudias, Pavlos, additional, Vrachnis, Dionysios, additional, Panagopoulos, Periklis, additional, Drakakis, Peter, additional, and Stavros, Sofoklis, additional

Published
2023
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20. Detection of GSTM1—null Genotype in Women Undergoing IVF Treatment

Author

Chrysanthopoulos, Ioannis, primary, Petsavas, Angelos, additional, Mavrogianni, Despoina, additional, Potiris, Anastasios, additional, Machairiotis, Nikolaos, additional, Drakaki, Eirini, additional, Vrachnis, Dionysios, additional, Machairoudias, Pavlos, additional, Karampitsakos, Theodoros, additional, Perros, Paraskevas, additional, Koratzanis, Christos, additional, Drakakis, Peter, additional, and Stavros, Sofoklis, additional

Published
2023
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22. Detection and Quantification of Acrylamide in Second Trimester Amniotic Fluid Using a Novel LC-MS/MS Technique to Determine Whether High Acrylamide Content during Pregnancy Is Associated with Fetal Growth

Author

Vrachnis, Nikolaos, primary, Loukas, Nikolaos, additional, Antonakopoulos, Nikolaos, additional, Maragou, Niki, additional, Kostakis, Marios, additional, Tsakni, Aliki, additional, Vrachnis, Dionysios, additional, Vougiouklaki, Despina, additional, Machairiotis, Nikolaos, additional, Chatzilazarou, Arhodoula, additional, Houhoula, Dimitra, additional, Sokou, Rozeta, additional, Stavros, Sofoklis, additional, Drakakis, Peter, additional, Mastorakos, George, additional, and Iliodromiti, Zoi, additional

Published
2023
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23. Association of GSTM1 Polymorphism and Redox Potential with Idiopathic Male Infertility

Author

Potiris, Anastasios, primary, Voitse, Anastasia, additional, Mavrogianni, Despoina, additional, Machairiotis, Nikolaos, additional, Drakaki, Eirini, additional, Papamentzelopoulou, Myrto, additional, Karampitsakos, Theodoros, additional, Zikopoulos, Athanasios, additional, Evgeni, Evangelini, additional, Drakakis, Peter, additional, and Stavros, Sofoklis, additional

Published
2023
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24. Rare calcifying fibrous pseudotumor of the peritoneum in an adult woman as a random finding during laparoscopic surgery.

Author

Topis, Spyridon, Samaras, Menelaos, Potiris, Anastasios, Machairiotis, Nikolaos, Drakakis, Peter, and Stavros, Sofoklis

Subjects
LAPAROSCOPIC surgery, PERITONEUM, CRYSTAL field theory, GYNECOLOGISTS, MUSCLE tumors
Abstract

Key Clinical Message: Calcifying fibrous pseudotumors (CFT) are rare benign lesions diagnosed by histological and immunohistochemical studies. Our case presents a rare detection of a CFT in the parietal peritoneum. These lesions can be falsely interpreted as myomas or adnexal masses and thus gynecologists should be aware of the existence of CFTs. [ABSTRACT FROM AUTHOR]

Published
2024
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25. ANRIL rs4977574 Gene Polymorphism in Women with Recurrent Pregnancy Loss

Author

Cherouveim, Panagiotis, primary, Mavrogianni, Despoina, additional, Drakaki, Eirini, additional, Potiris, Anastasios, additional, Zikopoulos, Athanasios, additional, Papamentzelopoulou, Myrto, additional, Kouvoutsaki, Konstantina, additional, Machairiotis, Nikolaos, additional, Karampitsakos, Theodoros, additional, Skentou, Chara, additional, Domali, Ekaterini, additional, Vrachnis, Nikolaos, additional, Drakakis, Peter, additional, and Stavros, Sofoklis, additional

Published
2023
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26. Epithelial Ovarian Cancer: A Five Year Review

Author

Arnaoutoglou, Christos, primary, Dampala, Kalliopi, additional, Anthoulakis, Christos, additional, Papanikolaou, Evangelos G., additional, Tentas, Ioannis, additional, Dragoutsos, Georgios, additional, Machairiotis, Nikolaos, additional, Zarogoulidis, Paul, additional, Ioannidis, Aristeidis, additional, Matthaios, Dimitris, additional, Perdikouri, Eleni I., additional, Giannakidis, Dimitrios, additional, Sardeli, Chrysanthi, additional, Petousis, Stamatios, additional, Oikonomou, Panagoula, additional, Nikolaou, Christina, additional, Charalampidis, Charalampos, additional, and Sapalidis, Konstantinos, additional

Published
2023
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27. Detection and Quantification of Neurotrophin-3 (NT-3) and Nerve Growth Factor (NGF) Levels in Early Second Trimester Amniotic Fluid: Investigation into a Possible Correlation with Abnormal Fetal Growth Velocity Patterns

Author

Machairiotis, Nikolaos, primary, Vrachnis, Dionysios, additional, Antonakopoulos, Nikolaos, additional, Loukas, Nikolaos, additional, Fotiou, Alexandros, additional, Pergialiotis, Vasilios, additional, Stavros, Sofoklis, additional, Mantzou, Aimilia, additional, Maroudias, Georgios, additional, Iavazzo, Christos, additional, Kanaka-Gantenbein, Christina, additional, Drakakis, Petros, additional, Troupis, Theodore, additional, Vlasis, Konstantinos, additional, and Vrachnis, Nikolaos, additional

Published
2023
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29. Inguinal Lymph Node Metastasis as Sole Manifestation of Ovarian / Fallopian Tube Cancer: a Review of the Literature

Author

Stavros, Sofoklis, primary, Potiris, Anastasios, additional, Machairiotis, Nikolaos, additional, Fotiou, Alexandros, additional, Zarogoulidis, Pavlos, additional, Drakaki, Eirini, additional, Karampitsakos, Theodoros, additional, Koratzanis, Christos, additional, Michalopoulos, Spyridon, additional, Vrachnis, Dionysios, additional, Oikonomou, Panagoula, additional, Christina, Nikolaou, additional, Charalampidis, Charalampos, additional, Petousis, Stamatios, additional, Ioannidis, Aris, additional, Matthaios, Dimitris, additional, Domali, Ekaterini, additional, and Drakakis, Peter, additional

Published
2023
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32. The Formidable yet Unresolved Interplay between Endometriosis and Obesity

Author

Pantelis, Athanasios, Machairiotis, Nikolaos, and Lapatsanis, Dimitris P.

Subjects
Article Subject
Abstract

Obesity and endometriosis are two very common entities, yet there is uncertainty on their exact relationship. Observational studies have repeatedly shown an inverse correlation between endometriosis and a low body mass index (BMI). However, obesity does not protect against endometriosis and on the contrary an increased BMI may lead to more severe forms of the disease. Besides, BMI is not accurate in all cases of obesity. Consequently, other anthropometric and phenomic traits have been studied, including body adiposity content, as well as the effect of BMI early in life on the manifestation of endometriosis in adulthood. Some studies have shown that the phenotypic inverse correlation between the two entities has a genetic background; however, others have indicated that certain polymorphisms are linked with endometriosis in females with increased BMI. The advent of metabolic bariatric surgery and pertinent research have led to the emergence of biomolecules that may be pivotal in understanding the pathophysiological interaction of the two entities, especially in the context of angiogenesis and inflammation. Future research should focus on three objectives: detection and interpretation of obesity-related biomarkers in experimental models with endometriosis; integration of endometriosis-related queries into bariatric registries; and multidisciplinary approach and collaboration among specialists.

Published
2021
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36. Perinatal management of enlarged bronchogenic cyst causing hydrops fetalis

Author

Arnaoutoglou, Christos, primary, Spyrakos, Spyros, additional, Kapetanaki, Anastasia, additional, Keivanidou, Anastasia, additional, Machairiotis, Nikolaos, additional, Zarogoulidis, Paul, additional, Tsakiridis, Kosmas, additional, Ioannidis, Aris, additional, Saroglou, Maria, additional, Tryfon, Stavros, additional, Tsigaras, Georgios, additional, and Papaioannou, Georgios Konstantinos, additional

Published
2021
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40. Genes’ Interactions: A Major Contributor to the Malignant Transformation of Endometriosis

Author

Sapalidis, Konstantinos, primary, Machairiotis, Nikolaos, additional, Zarogoulidis, Paul, additional, Vasilakaki, Sofia, additional, Sardeli, Chrysanthi, additional, Koimtzis, George, additional, Pavlidis, Efstathios, additional, Katsaounis, Athanasios, additional, Giannakidis, Dimitrios, additional, Michalopoulos, Nikolaos, additional, Mantalobas, Stylianos, additional, Alexandrou, Vyron, additional, Koulouris, Charilaos, additional, Amaniti, Aikaterini, additional, and Kesisoglou, Isaak, additional

Published
2019
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41. How do different histologic components of mixed endometrial carcinomas affect prognosis? Does it really matter?

Author

Thomakos, Nikolaos, Dimopoulou, Stefania, Sotiropoulou, Maria, Machairiotis, Nikolaos, Pandraklakis, Anastasios, Haidopoulos, Dimitrios, Liontos, Michalis, Bamias, Aristotelis, and Rodolakis, Alexandros

Subjects
ENDOMETRIAL cancer, UTERINE cancer, METASTASIS, SURVIVAL analysis (Biometry), OMENTUM, PROGNOSIS
Abstract

The aim of this study is to evaluate and compare outcomes of patients with mixed and pure endometrial carcinomas (MEC). We reviewed data of patients with MEC, endometroid (EC), serous (SC), and clear cell (CC) carcinomas between 2002 and 2015. Overall survival (OS) and disease-free (DF) survival rates were evaluated, according to the percentage of histologic components. Clinicopathological variables and treatment strategies were assessed. Furthermore, χ2 tests were used to compare proportions and Kaplan–Meier curves to compare recurrence and survival. Sample consisted of 302 cases with mean age 66.3 years. Early-stage disease was recorded in EC compared with CC and SC. Adnexal involvement was more frequent in MEC compared with EC (p=0.043). Extra uterine metastasis was more frequent in the SC compared to the EC group, while lymphovascular space involvement was more frequent in the MEC and CC compared to the SC (p=0.001). EC had less omentum involvement compared to CC (p=0.035) and SC (p<0.001). Furthermore, cervical involvement was more frequent in CC compared to EC (p=0.011). Recurrence (p=0.265) and OS (p=0.533) were found to be similar in MEC compared with CC, SC, and EC. Moreover, recurrence and OS were similar between EC-CC and EC-SC. There were no differences in recurrence and survival in MEC with a type II component larger than 10% or 20% (p>0.05). [ABSTRACT FROM AUTHOR]

Published
2021
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44. Postoperative pain management

Author

Kolettas, Alexandros, Lazaridis, George, Baka, Sofia, Mpoukovinas, Ioannis, Karavasilis, Vasilis, Kioumis, Ioannis, Pitsiou, Georgia, Papaiwannou, Antonis, Lampaki, Sofia, Karavergou, Anastasia, Pataka, Athanasia, Machairiotis, Nikolaos, Katsikogiannis, Nikolaos, Mpakas, Andreas, Tsakiridis, Kosmas, Fassiadis, Nikolaos, Zarogoulidis, Konstantinos, and Zarogoulidis, Paul

Subjects
Review Article
Abstract

Postoperative pain is a very important issue for several patients. Indifferent of the surgery type or method, pain management is very necessary. The relief from suffering leads to early mobilization, less hospital stay, reduced hospital costs, and increased patient satisfaction. An individual approach should be applied for pain control, rather than a fix dose or drugs. Additionally, medical, psychological, and physical condition, age, level of fear or anxiety, surgical procedure, personal preference, and response to agents given should be taken into account. The major goal in the management of postoperative pain is minimizing the dose of medications to lessen side effects while still providing adequate analgesia. Again a multidisciplinary team approach should be pursued planning and formulating a plan for pain relief, particularly in complicated patients, such as those who have medical comorbidities. These patients might appear increase for analgesia-related complications or side effects.

Published
2015

45. Unusual causes of pneumothorax

Author

Ouellette, Daniel R., Parrish, Scott, Browning, Robert F., Turner, J. Francis, Zarogoulidis, Konstantinos, Kougioumtzi, Ioanna, Dryllis, Georgios, Kioumis, Ioannis, Pitsiou, Georgia, Machairiotis, Nikolaos, Katsikogiannis, Nikolaos, Tsiouda, Theodora, Madesis, Athanasios, Karaiskos, Theodoros, and Zarogoulidis, Paul

Subjects
surgical procedures, operative, Review Article, respiratory system, respiratory tract diseases
Abstract

Pneumothorax is divided to primary and secondary. It is a situation that requires immediate treatment, otherwise it could have severe health consequences. Pneumothorax can be treated either by thoracic surgeons, or pulmonary physicians. In our current work, we will focus on unusual cases of pneumothorax. We will provide the etiology and treatment for each case, also a discussion will be made for each situation.

Published
2014

46. Transbronchial lung biopsy and pneumothorax

Author

Huang, Yong, Huang, Haidong, Li, Qiang, Browning, Robert F., Parrish, Scott, Turner, J. Francis, Zarogoulidis, Konstantinos, Kougioumtzi, Ioanna, Dryllis, Georgios, Kioumis, Ioannis, Pitsiou, Georgia, Papaiwannou, Antonis, Lampaki, Sofia, Machairiotis, Nikolaos, Katsikogiannis, Nikolaos, Madesis, Athanasios, Karaiskos, Theodoros, Li, Zhigang, and Zarogoulidis, Paul

Subjects
surgical procedures, operative, Review Article, respiratory tract diseases
Abstract

Mini-interventional procedures are used in the everyday clinical practice by pulmonary physicians and radiologists. Fine needle aspiration and biopsy forceps are the tools mostly used. During these procedures pneumothorax can occur and immediate treatment is necessary. In our current work, we will focus on minimal invasive techniques for biopsy and pneumothorax treatment.

Published
2014

47. Pneumothorax: observation

Author

Li, Zhigang, Huang, Haidong, Li, Qiang, Zarogoulidis, Konstantinos, Kougioumtzi, Ioanna, Dryllis, Georgios, Kioumis, Ioannis, Pitsiou, Georgia, Machairiotis, Nikolaos, Katsikogiannis, Nikolaos, Papaiwannou, Antonis, Madesis, Athanasios, Diplaris, Konstantinos, Karaiskos, Theodoros, Zaric, Bojan, Branislav, Perin, and Zarogoulidis, Paul

Subjects
surgical procedures, operative, Review Article, respiratory tract diseases
Abstract

Pneumothorax based on the cause, it can be divided into two large categories; primary and secondary. The staging of pneumothorax plays a crucial role for treatment. Currently both thoracic surgeons and pulmonary physicians can handle efficiently treatment. Pulmonary physicians with the minimally medical thoracoscopy while thoracic surgeons with a more extensive intervention. Experience defines the outcome in most situations and not the method. In our current work we will present data regarding the observation of pneumothorax from a panel of experts.

Published
2014

48. Tube thoracostomy; chest tube implantation and follow up

Author

Kuhajda, Ivan, Zarogoulidis, Konstantinos, Kougioumtzi, Ioanna, Huang, Haidong, Li, Qiang, Dryllis, Georgios, Kioumis, Ioannis, Pitsiou, Georgia, Machairiotis, Nikolaos, Katsikogiannis, Nikolaos, Papaiwannou, Antonis, Lampaki, Sofia, Zaric, Bojan, Branislav, Perin, Porpodis, Konstantinos, and Zarogoulidis, Paul

Subjects
fungi, food and beverages, Review Article
Abstract

Pneumothorax is an urgent medical situation that requires urgent treatment. We can divide this entity based on the etiology to primary and secondary. Chest tube implantation can be performed either in the upper chest wall or lower. Both thoracic surgeons and pulmonary physicians can place a chest tube with minimal invasive techniques. In our current work, we will demonstrate chest tube implantation to locations, methodology and tools.

Published
2014

49. Pneumothorax after transbronchial needle biopsy

Author

Boskovic, Tatjana, Stojanovic, Milos, Stanic, Jelena, Pena Karan, Slobodanka, Vujasinovic, Gordana, Dragisic, Dragan, Zarogoulidis, Konstantinos, Kougioumtzi, Ioanna, Dryllis, Georgios, Kioumis, Ioannis, Pitsiou, Georgia, Machairiotis, Nikolaos, Katsikogiannis, Nikolaos, Papaiwannou, Antonis, Madesis, Athanasios, Diplaris, Konstantinos, Karaiskos, Theodoros, Zaric, Bojan, Branislav, Perin, and Zarogoulidis, Paul

Subjects
surgical procedures, operative, Review Article
Abstract

Currently there several diagnostic techniques that re used by radiologists and pulmonary physicians for lung cancer diagnostics. In several cases pneumothorax (PNTX) is induced and immediate action is needed. Both radiologists and pulmonary physicians can insert a chest tube for symptom relief. However; only pulmonary physicians and thoracic surgeons can provide a permanent solution for the patient. The final solution would be for a patient to undergo surgery for a final solution. In our current work we will provide all those diagnostic cases where PNTX is induced and treatment from the point of view of expert radiologists and pulmonary physicians.

Published
2014

50. Laparoscopy induced pneumothorax

Author

Machairiotis, Nikolaos, Kougioumtzi, Ioanna, Dryllis, Georgios, Katsikogiannis, Nikolaos, Katsikogianni, Fotini, Courcoutsakis, Nikolaos, Kioumis, Ioannis, Pitsiou, Georgia, Zarogoulidis, Konstantinos, and Zarogoulidis, Paul

Subjects
Editorial
Published
2014

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