481 results on '"Machado-Neto, João Agostinho"'
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2. Tartrolon D induces immunogenic cell death in melanoma
3. Potency and efficacy of pharmacological PIP4K2 inhibitors in acute lymphoblastic leukemia
4. Cyclopenta[b]indoles as novel antimicrotubule agents with antileukemia activity
5. Comprehensive analysis of the HCK gene in myeloid neoplasms: Insights into biological functions, prognosis, and response to antineoplastic agents
6. Seriniquinones as Therapeutic Leads for Treatment of BRAF and NRAS Mutant Melanomas.
7. NT157 exhibits antineoplastic effects by targeting IRS and STAT3/5 signaling in multiple myeloma
8. Acute myeloid leukemia-derived bone marrow mesenchymal cells exhibit improved support for leukemic cell proliferation
9. Antineoplastic effects of pharmacological inhibitors of aurora kinases in CSF3RT618I-driven cells
10. Monoolein-based nanodispersions for cutaneous co-delivery of methylene blue and metformin: Thermal and structural characterization and effects on the cutaneous barrier, skin penetration and cytotoxicity
11. NSC305787, a pharmacological ezrin inhibitor, exhibits antineoplastic activity in pancreatic cancer cells
12. NT157 as an Anticancer Drug Candidate That Targets Kinase- and Phosphatase-Mediated Signaling
13. Bismuth(III) triflate: an economical and environmentally friendly catalyst for the Nazarov reaction
14. Phenformin increases early hematopoietic progenitors in the Jak2V617F murine model
15. Ezrin is highly expressed and a druggable target in chronic lymphocytic leukemia
16. AD80, a multikinase inhibitor, as a potential drug candidate for colorectal cancer therapy
17. STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells
18. NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells
19. The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy
20. Exploring redox vulnerabilities in JAK2V617F-positive cellular models
21. Comprehensive analysis of cytoskeleton regulatory genes identifies ezrin as a prognostic marker and molecular target in acute myeloid leukemia
22. AD80, a multikinase inhibitor, exhibits antineoplastic effects in acute leukemia cellular models targeting the PI3K/STMN1 axis
23. Proteolytic processing in autophagy
24. Contributors
25. DNA damaging agents and DNA repair: From carcinogenesis to cancer therapy
26. NT157, an IGF1R-IRS1/2 inhibitor, exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia
27. Two-Dimensional and Spheroid-Based Three-Dimensional Cell Culture Systems: Implications for Drug Discovery in Cancer.
28. Clinical and molecular profile of a Brazilian cohort of patients with classical BCR-ABL1-negative myeloproliferative neoplasms
29. ARHGAP6 transcript levels are associated with molecular risk and impact survival outcomes in acute myeloid leukemia
30. Acute myeloid leukemia-derived bone marrow mesenchymal cells exhibit improved support for leukemic cell proliferation
31. Reversine exerts cytotoxic effects through multiple cell death mechanisms in acute lymphoblastic leukemia
32. Stathmin 1 is highly expressed and associated with survival outcome in malignant adrenocortical tumours
33. Autophagy inhibition potentiates ruxolitinib-induced apoptosis in JAK2V617F cells
34. PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia
35. Hydrogen Sulfide Signaling in the Tumor Microenvironment: Implications in Cancer Progression and Therapy.
36. Data mining in acute myeloid leukemia: identification of disease biomarkers, prognostic factors, novel targets, and potential drugs
37. Hydrogen sulfide signaling in the tumor microenvironment: implications in cancer progression and therapy
38. Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis
39. The Multikinase Inhibitor AD80 Induces Mitotic Catastrophe and Autophagy in Pancreatic Cancer Cells
40. Paclitaxel induces Stathmin 1 phosphorylation, microtubule stability and apoptosis in acute lymphoblastic leukemia cells
41. NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells
42. Pharmacological Inhibition of PIP4K2 Potentiates Venetoclax-Induced Apoptosis in Acute Myeloid Leukemia.
43. Silencing of ARHGAP21, a Rho GTPase activating protein (RhoGAP), reduces the growth of prostate cancer xenografts in NOD/SCID mice
44. Exploring pradimicin-IRD antineoplastic mechanisms and related DNA repair pathways
45. Reversine triggers mitotic catastrophe and apoptosis in K562 cells
46. Reversine exhibits antineoplastic activity in JAK2V617F-positive myeloproliferative neoplasms
47. Perspectives for Targeting Ezrin in Cancer Development and Progression
48. Differential profile of PIP4K2A expression in hematological malignancies
49. Cellular and Molecular Effects of Eribulin in Preclinical Models of Hematologic Neoplasms
50. Ezrin Is a Potential Druggable Target in Chronic Lymphocytic Leukemia
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