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Your search keyword '"Maceski, Aleksandra Maleska"' showing total 21 results
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21 results on '"Maceski, Aleksandra Maleska"'

1. MultiSCRIPT-Cycle 1—a pragmatic trial embedded within the Swiss Multiple Sclerosis Cohort (SMSC) on neurofilament light chain monitoring to inform personalized treatment decisions in multiple sclerosis: a study protocol for a randomized clinical trial

Author

Janiaud, Perrine, Zecca, Chiara, Salmen, Anke, Benkert, Pascal, Schädelin, Sabine, Orleth, Annette, Demuth, Lilian, Maceski, Aleksandra Maleska, Granziera, Cristina, Oechtering, Johanna, Leppert, David, Derfuss, Tobias, Achtnichts, Lutz, Findling, Oliver, Roth, Patrick, Lalive, Patrice, Uginet, Marjolaine, Müller, Stefanie, Pot, Caroline, Hoepner, Robert, Disanto, Giulio, Gobbi, Claudio, Rooshenas, Leila, Schwenkglenks, Matthias, Lambiris, Mark J., Kappos, Ludwig, Kuhle, Jens, Yaldizli, Özgür, and Hemkens, Lars G.

Published
2024
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4. Neuroprotective associations of apolipoproteins A-I and A-II with neurofilament levels in early multiple sclerosis

Author

McComb, Mason, Krikheli, Maggie, Uher, Tomas, Browne, Richard W., Srpova, Barbora, Oechtering, Johanna, Maceski, Aleksandra Maleska, Tyblova, Michaela, Jakimovski, Dejan, Ramasamy, Deepa P., Bergsland, Niels, Krasensky, Jan, Noskova, Libuse, Fialova, Lenka, Weinstock-Guttman, Bianca, Havrdova, Eva Kubala, Vaneckova, Manuela, Zivadinov, Robert, Horakova, Dana, Kuhle, Jens, and Ramanathan, Murali

Published
2020
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6. Use of dried blood spots for monitoring inflammatory and nutritional biomarkers in the elderly.

Author

Vialaret, Jérôme, Vignon, Margaux, Hirtz, Christophe, Badiou, Stéphanie, Baptista, Gregory, Fichter, Laura, Dupuy, Anne-Marie, Maceski, Aleksandra Maleska, Fayolle, Martin, Brousse, Mehdi, Cristol, Jean-Paul, Jeandel, Claude, and Lehmann, Sylvain

Subjects
BLOOD proteins, OLDER people, TRANSFERRIN, NUTRITIONAL status, BIOMARKERS, MASS spectrometry, C-reactive protein
Abstract

Blood microsampling, particularly dried blood spots (DBSs), is an attractive minimally-invasive approach that is well suited for home sampling and predictive medicine associated with longitudinal follow-up of the elderly. However, in vitro diagnostic quantification of biomarkers from DBS poses a major challenge. Clinical mass spectrometry can reliably quantify blood proteins in various research projects. Our goal here was to use mass spectrometry of DBS in a real-world clinical setting and compared it to the standard immunoassay method. We also sought to correlate DBS mass spectrometry measurements with clinical indices. A clinical trial of diagnostic equivalence was conducted to compare conventional venous samples quantified by immunoassay and DBSs quantified by mass spectrometry in an elderly population. We assayed three protein biomarkers of nutritional and inflammatory status: prealbumin (transthyretin), C-reactive protein, and transferrin. The analysis of DBSs showed satisfactory variability and low detection limits. Statistical analysis confirmed that the two methods give comparable results at clinical levels of accuracy. In conclusion, we demonstrated, in a real-life setting, that DBSs can be used to measure prealbumin, CRP and transferrin, which are commonly used markers of nutritional status and inflammation in the elderly. However, there was no correlation with patient frailty for these proteins. Early detection and regular monitoring of nutritional and inflammatory problems using DBS appear to be clinically feasible. This could help resolve major public health challenges in the elderly for whom frailty leads to serious risks of health complications. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Use of dried blood spots for monitoring inflammatory and nutritional biomarkers in the elderly

Author

Vialaret, Jérôme, primary, Vignon, Margaux, additional, Hirtz, Christophe, additional, Badiou, Stéphanie, additional, Baptista, Gregory, additional, Fichter, Laura, additional, Dupuy, Anne-Marie, additional, Maceski, Aleksandra Maleska, additional, Fayolle, Martin, additional, Brousse, Mehdi, additional, Cristol, Jean-Paul, additional, Jeandel, Claude, additional, and Lehmann, Sylvain, additional

Published
2023
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8. Diagnostic delay of multiple sclerosis: prevalence, determinants and consequences

Author

Uher, Tomas, primary, Adzima, Adrian, additional, Srpova, Barbora, additional, Noskova, Libuse, additional, Maréchal, Bénédicte, additional, Maceski, Aleksandra Maleska, additional, Krasensky, Jan, additional, Stastna, Dominika, additional, Andelova, Michaela, additional, Novotna, Klara, additional, Vodehnalova, Karolina, additional, Motyl, Jiri, additional, Friedova, Lucie, additional, Lindner, Jiri, additional, Ravano, Veronica, additional, Burgetova, Andrea, additional, Dusek, Petr, additional, Fialova, Lenka, additional, Havrdova, Eva Kubala, additional, Horakova, Dana, additional, Kober, Tobias, additional, Kuhle, Jens, additional, and Vaneckova, Manuela, additional

Published
2023
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9. Optical coherence tomography versus other biomarkers: Associations with physical and cognitive disability in multiple sclerosis

Author

Cerdá-Fuertes, Nuria, primary, Stoessel, Marc, additional, Mickeliunas, Gintaras, additional, Pless, Silvan, additional, Cagol, Alessandro, additional, Barakovic, Muhamed, additional, Maceski, Aleksandra Maleska, additional, Álvarez González, Cesar, additional, D’ Souza, Marcus, additional, Schaedlin, Sabine, additional, Benkert, Pascal, additional, Calabrese, Pasquale, additional, Gugleta, Konstantin, additional, Derfuss, Tobias, additional, Sprenger, Till, additional, Granziera, Cristina, additional, Naegelin, Yvonne, additional, Kappos, Ludwig, additional, Kuhle, Jens, additional, and Papadopoulou, Athina, additional

Published
2023
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10. Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

Author

Fortea, Juan, Carmona-Iragui, María, Benejam, Bessy, Fernández, Susana, Videla, Laura, Barroeta, Isabel, Alcolea, Daniel, Pegueroles, Jordi, Muñoz, Laia, Belbin, Olivia, de Leon, Mony J, Maceski, Aleksandra Maleska, Hirtz, Christophe, Clarimón, Jordi, Videla, Sebastián, Delaby, Constance, Lehmann, Sylvain, Blesa, Rafael, and Lleó, Alberto

Published
2018
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11. Serum tau protein elevation in migraine: a cross-sectional case- control study

Author

Overeem, Lucas Hendrik, primary, Raffaelli, Bianca, additional, Fleischmann, Robert, additional, Süße, Marie, additional, Vogelgesang, Antje, additional, Maceski, Aleksandra Maleska, additional, Papadopoulou, Athina, additional, Ruprecht, Klemens, additional, Su, Wendy, additional, Koch, Mirja, additional, Siebert, Anke, additional, Arkuszewski, Michal, additional, Tenenbaum, Nadia, additional, Kuhle, Jens, additional, and Reuter, Uwe, additional

Published
2023
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12. Serum Glial Fibrillary Acidic Protein compared with Neurofilament Light Chain as Biomarker for Multiple Sclerosis Disease Progression (P5-3.016)

Author

Meier, Stephanie, primary, Benkert, Pascal, additional, Maceski, Aleksandra Maleska, additional, Schaedelin, Sabine, additional, Oechtering, Johanna, additional, Melie-Garcia, Lester, additional, Cagol, Alessandro, additional, Barakovic, Muhamed, additional, Galbusera, Riccardo, additional, Achtnichts, Lutz, additional, Lalive, Patrice H., additional, Bridel, Claire, additional, Müller, Stefanie, additional, Pot, Caroline, additional, Salmen, Anke, additional, Disanto, Giulio, additional, Zecca, Chiara, additional, Abdelhak, Ahmed, additional, Barro, Christian, additional, Thebault, Simon, additional, D’Souza, Marcus, additional, Derfuss, Tobias, additional, Orleth, Annette, additional, Khalil, Michael, additional, Yaldizli, Özguer, additional, Hermesdorf, Marco, additional, Wiendl, Heinz, additional, Piehl, Fredrik, additional, Fischer, Urs, additional, Kappos, Ludwig, additional, Gobbi, Claudio, additional, Granziera, Cristina, additional, Leppert, David, additional, Willemse, Eline A.J., additional, and Kuhle, Jens, additional

Published
2023
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13. New Perspectives of Multiplex Mass Spectrometry Blood Protein Quantification on Microsamples in Biological Monitoring of Elderly Patients

Author

Vialaret, Jérôme, primary, Vignon, Margaux, additional, Badiou, Stéphanie, additional, Baptista, Gregory, additional, Fichter, Laura, additional, Dupuy, Anne-Marie, additional, Maceski, Aleksandra Maleska, additional, Fayolle, Martin, additional, Brousse, Mehdi, additional, Cristol, Jean-Paul, additional, Jeandel, Claude, additional, Hirtz, Christophe, additional, and Lehmann, Sylvain, additional

Published
2023
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14. High serum neurofilament light chain levels correlate with brain atrophy and physical disability in multiple sclerosis

Author

Buchmann, Arabella, primary, Pirpamer, Lukas, additional, Pinter, Daniela, additional, Voortman, Margarete, additional, Helmlinger, Birgit, additional, Pichler, Alexander, additional, Maceski, Aleksandra Maleska, additional, Benkert, Pascal, additional, Bachmaier, Gerhard, additional, Ropele, Stefan, additional, Reindl, Markus, additional, Leppert, David, additional, Kuhle, Jens, additional, Enzinger, Christian, additional, and Khalil, Michael, additional

Published
2023
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15. GnRH replacement rescues cognition in Down syndrome

Author

Manfredi-Lozano, Maria, primary, Leysen, Valerie, additional, Adamo, Michela, additional, Paiva, Isabel, additional, Rovera, Renaud, additional, Pignat, Jean-Michel, additional, Timzoura, Fatima Ezzahra, additional, Candlish, Michael, additional, Eddarkaoui, Sabiha, additional, Malone, Samuel A., additional, Silva, Mauro S. B., additional, Trova, Sara, additional, Imbernon, Monica, additional, Decoster, Laurine, additional, Cotellessa, Ludovica, additional, Tena-Sempere, Manuel, additional, Claret, Marc, additional, Paoloni-Giacobino, Ariane, additional, Plassard, Damien, additional, Paccou, Emmanuelle, additional, Vionnet, Nathalie, additional, Acierno, James, additional, Maceski, Aleksandra Maleska, additional, Lutti, Antoine, additional, Pfrieger, Frank, additional, Rasika, S., additional, Santoni, Federico, additional, Boehm, Ulrich, additional, Ciofi, Philippe, additional, Buée, Luc, additional, Haddjeri, Nasser, additional, Boutillier, Anne-Laurence, additional, Kuhle, Jens, additional, Messina, Andrea, additional, Draganski, Bogdan, additional, Giacobini, Paolo, additional, Pitteloud, Nelly, additional, and Prevot, Vincent, additional

Published
2022
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17. Serum neurofilament light chain captures and predicts confirmed progression independent of relapses (PIRA) in multiple sclerosis

Author

Lorscheider, Johannes, Benkert, Pascal, Yaldizli, Özgür, Disanto, Giulio, Oechtering, Johanna, Wuerfel, Jens, Chan, Andrew, Achtnichts, Lutz, Findling, Oliver, Derfuss, Tobias, Kropshofer, Harald, Orleth, Annette, Barnicol, Bettina Fischer, Aeschbacher, Stefanie, Maceski, Aleksandra Maleska, Rey, Dimitri, Zadic, Sabrina, Müller, Christian, Waubant, Emmanuelle, Oksenberg, Jorge, Wellmann, Sven, Wiendl, Heinz, Kappos, Ludwig, Salmen, Anke, Hoepner, Robert, Lalive, Patrice, Pasquier, Renaud A Du, Pot, Caroline, Maggi, Pietro, Zecca, Chiara, Naegelin, Yvonne, Müller, Stefanie, Hrusovsky, Kevin, Berger, Klaus, Conen, David, Barakovic, Muhamed, Sinnecker, Tim, Gobbi, Claudio, Granziera, Cristina, Leppert, David, and Kuhle, Jens

Published
2020
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18. Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019

Author

Sutter, Raoul, primary, Hert, Lisa, additional, De Marchis, Gian Marco, additional, Twerenbold, Raphael, additional, Kappos, Ludwig, additional, Naegelin, Yvonne, additional, Kuster, Gabriela M., additional, Benkert, Pascal, additional, Jost, Jasmine, additional, Maceski, Aleksandra Maleska, additional, Rüegg, Stephan, additional, Siegemund, Martin, additional, Leppert, David, additional, Tschudin‐Sutter, Sarah, additional, and Kuhle, Jens, additional

Published
2021
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20. Serum Neurofilament Light Chain and Glial Fibrillary Acid Protein in Patients With Multiple Sclerosis (P5.2-006)

Author

ayrignac, xavier, primary, Maceski, Aleksandra Maleska, additional, Carra-Dalliere, Clarisse, additional, Charif, Mahmoud, additional, Catteau, Cyndi, additional, Ginestet, Nelly, additional, Prin, Pauline, additional, Corti, Lucas, additional, Pinna, Frédéric, additional, Lehmann, Sylvain, additional, and Labauge, Pierre, additional

Published
2019
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21. Optical coherence tomography versus other biomarkers: Associations with physical and cognitive disability in multiple sclerosis.

Author

Cerdá-Fuertes N, Stoessel M, Mickeliunas G, Pless S, Cagol A, Barakovic M, Maceski AM, Álvarez González C, D' Souza M, Schaedlin S, Benkert P, Calabrese P, Gugleta K, Derfuss T, Sprenger T, Granziera C, Naegelin Y, Kappos L, Kuhle J, and Papadopoulou A

Abstract

Background: Optical coherence tomography (OCT) is a biomarker of neuroaxonal loss in multiple sclerosis (MS)., Objective: The objective was to assess the relative role of OCT, next to magnetic resonance imaging (MRI) and serum markers of disability in MS., Methods: A total of 100 patients and 52 controls underwent OCT to determine peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell-inner plexiform layers (GCIPL). Serum neurofilament light chain (sNfL), total lesion volume (TLV), and brain parenchymal fraction (BPF) were also assessed. The associations of OCT with disability were examined in linear regression models with correction for age, vision, and education., Results: In patients, pRNFL was associated with the Symbol Digit Modalities Test (SDMT; p = 0.030). In the multivariate analysis including sNfL and MRI measures, pRNFL (β = 0.19, p = 0.044) and TLV (β = -0.24, p = 0.023) were the only markers associated with the SDMT. pRNFL ( p < 0.001) and GCIPL ( p < 0.001) showed associations with the Expanded Disability Status Scale (EDSS). In the multivariate analysis, GCIPL showed the strongest association with the EDSS (β = -0.32, p < 0.001) followed by sNfL (β = 0.18, p = 0.024)., Conclusion: The associations of OCT measures with cognitive and physical disability were independent of serum and brain MRI markers of neuroaxonal loss. OCT can be an important tool for stratification in MS, while longitudinal studies using combinations of biomarkers are warranted.

Published
2023
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