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11 results on '"Macedo, M. Fatima"'

1. Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin

Author

Melum, Espen, Jiang, Xiaojun, Baker, Kristi D., Macedo, M. Fatima, Fritsch, Jürgen, Dowds, C. Marie, Wang, Jing, Pharo, Anne, Kaser, Arthur, Tan, Corey, Pereira, Catia S., Kelly, Samuel L., Duan, Jingjing, Karlsen, Tom H., Exley, Mark A., Schütze, Stefan, Zajonc, Dirk M., Merrill, Alfred H., Schuchman, Edward H., Zeissig, Sebastian, and Blumberg, Richard S.

Published
2019
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6. Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients

Author

Pereira, Catia S., primary, Pérez-Cabezas, Begoña, additional, Ribeiro, Helena, additional, Maia, M. Luz, additional, Cardoso, M. Teresa, additional, Dias, Ana F., additional, Azevedo, Olga, additional, Ferreira, M. Fatima, additional, Garcia, Paula, additional, Rodrigues, Esmeralda, additional, Castro-Chaves, Paulo, additional, Martins, Esmeralda, additional, Aguiar, Patricio, additional, Pineda, Mercè, additional, Amraoui, Yasmina, additional, Fecarotta, Simona, additional, Leão-Teles, Elisa, additional, Deng, Shenglou, additional, Savage, Paul B., additional, and Macedo, M. Fatima, additional

Published
2019
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7. CD1-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity

Author

Pereira, Catia S. and Macedo, M. Fatima

Subjects
Article Subject, parasitic diseases, hemic and immune systems, chemical and pharmacologic phenomena, lipids (amino acids, peptides, and proteins), complex mixtures
Abstract

Lipid-specific T cells comprise a group of T cells that recognize lipids bound to the MHC class I-like CD1 molecules. There are four isoforms of CD1 that are expressed at the surface of antigen presenting cells and therefore capable of presenting lipid antigens: CD1a, CD1b, CD1c, and CD1d. Each one of these isoforms has distinct structural features and cellular localizations, which promotes binding to a broad range of different types of lipids. Lipid antigens originate from either self-tissues or foreign sources, such as bacteria, fungus, or plants and their recognition by CD1-restricted T cells has important implications in infection but also in cancer and autoimmunity. In this review, we describe the characteristics of CD1 molecules and CD1-restricted lipid-specific T cells, highlighting the innate-like and adaptive-like features of different CD1-restricted T cell subtypes.

Published
2016
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8. From Lysosomal Storage Diseases to NKT Cell Activation and Back.

Author

Pereira, Cátia S., Ribeiro, Helena, and Macedo, M. Fatima

Subjects
LYSOSOMAL storage diseases, LYSOSOMES, LIPIDS, PATHOLOGY, IMMUNE system
Abstract

Lysosomal storage diseases (LSDs) are inherited metabolic disorders characterized by the accumulation of different types of substrates in the lysosome. With a multisystemic involvement, LSDs often present a very broad clinical spectrum. In many LSDs, alterations of the immune system were described. Special emphasis was given to Natural Killer T (NKT) cells, a population of lipid-specific T cells that is activated by lipid antigens bound to CD1d (cluster of differentiation 1 d) molecules at the surface of antigen-presenting cells. These cells have important functions in cancer, infection, and autoimmunity and were altered in a variety of LSDs' mouse models. In some cases, the observed decrease was attributed to defects in either lipid antigen availability, trafficking, processing, or loading in CD1d. Here, we review the current knowledge about NKT cells in the context of LSDs, including the alterations detected, the proposed mechanisms to explain these defects, and the relevance of these findings for disease pathology. Furthermore, the effect of enzyme replacement therapy on NKT cells is also discussed. [ABSTRACT FROM AUTHOR]

Published
2017
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