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18 results on '"Macedo, Ana S."'

13. Contributors

Author

Agrawal, Kapil, Ajazuddin, Alavian, Seyed Ehsan, Aldhaher, Abdullah, Alexander, Amit, Amaral, Mariana Neves, Ashammakhi, Nureddin, Babu, M. Arockia, Badwaik, Hemant, Baghel, Madhuri, Barve, Kalyani, Bhatt, Lokesh Kumar, Bhatt, Shvetank, Bhoi, Anita, Chauhan, Nagendra Singh, Chaurasiya, Narayan D., Choudhary, Rajesh, Devis, Sindy, Doseff, Andrea I., Dudekula, Jamal Basa, Dwivedi, Shradha Devi, Elnour, Ahmed A.M., Eluz, Ezgi Kayan, Fonseca, Magda, Fonte, Pedro, Gaspar, M. Manuela, Gidwani, Bina, Goyal, Sameer, Grenha, Ana, Guerrero, Simón, Jain, Atul, Jain, Vishal, Jha, Shikha, Joshi, Megha, Joshi, Veenu, Kaur, Jagpreet, Kaushik, Vichitra, Kaushik, Atul, Kenwat, Rameshroo, Keshavkant, S., Klagges, Carolina, Kumar, M. Sathish, Macedo, Ana S., Mangrulkar, Shubhada, Manoharlal, Raman, Moreno, Mabel, Naik, Gaurav Gopal, Nakhate, Kartik, Otero, Carolina, Özer, Asuman Yekta, Paliwal, Shivani Rai, Paliwal, Rishi, Pandey, Ravindra, Parihar, Niraj, Pinho, Jacinta O., Pontes, Jorge F., Pradhan, Kusum, Pradhan, Madhulika, Rao, US Mahadeva, Reis, Catarina Pinto, Sahu, Alakh N., Saiprasad, G.V.S., Sanchez-Ruderisch, Hugo, Sarkar, Biresh Kumar, Shah, Kamal, Shahabipour, Fahimeh, Sharma, Teenu, Shilpi, Satish, Shukla, Shiv Shankar, Singh, Deependra, Singh, Manju Rawat, Solar, Paula, Sulakhiya, Kunjbihari, Tekwani, Babu L., Tiwari, Akhilesh, Tiwari, Sakshi, Vaiphei, Klaudi K., Velásquez, Luis, Vyas, Amber, Yadav, Krishna, and Yadav, Pooja

Published
2023
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17. Nanoemulsions for delivery of flavonoids: formulation and in vitro release of rutin as model drug.

Author

Macedo, Ana S., Quelhas, Sara, Silva, Amélia M., and Souto, Eliana B.

Subjects
FLAVONOIDS, RUTIN, MICROSCOPY, LIGHT scattering, DRUG solubility
Abstract

The aim of the present study is to design and characterize a rutin-loaded nanoemulsion (RT-NE) and determine the release profile of the drug in vitro. RT-NE was prepared by a high pressure homogenization technique. The obtained droplets were analyzed by optical microscopy and were shown to be of spherical shape. By dynamic light scattering, characterization of RT-NE showed an average diameter of 127 nm, polydispersity index of 0.168 and zeta potential values near neutrality (−3.49 mV). Encapsulation efficiency was of ∼82% (82.3 ± 1.62%). Drug release was characterized by an initial burst which decreased over the time, showing a sustained release profile. After 24 h, rutin released from NE reached nearly 65%. The developed system proved to be stable and suitable to encapsulating poorly water-soluble drugs. [ABSTRACT FROM AUTHOR]

Published
2014
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18. Development of gel-core solid lipid nanoparticles as drug delivery systems for hydrophilic molecules

Author

Ana Sofia Macedo, Eliana B. Souto, Tatiana Andreani, Tatiana N. Pashirova, Lucia Ya. Zakharova, Pashirova, Tatiana N, Andreani, Tatiana, Macedo, Ana S, Souto, Eliana B, and Zakharova, Lucia Ya

Subjects
Chemistry, Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), Bioengineering, Core (manufacturing), 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, drug delivery systems, solid lipid nanoparticles, Chemical engineering, bovine serum albumin, Solid lipid nanoparticle, Drug delivery, Molecule, methylene blue, 0210 nano-technology, hydrogels, hydrophilic biomolecules, Biotechnology, rhodamine B
Abstract

Background: We report the development and characterization of gelcore solid lipid nanoparticles (SLN) for the encapsulation of hydrophilic proteins, taking bovine serum albumin (BSA) as model compound. Methods: SLN were produced by multiple emulsion (w/o/w) method, while hydrogels were produced by dissolving Carbopol 971 in purified water under high-speed stirring. Physicochemical characterization followed the pH determination, fluorescence and scanning electron microscopy analyses, and the quantification of the drugs by spectrophotometric measurements (for the determination of encapsulation efficiency and release profile). Results: The stability of SLN was found to be dependent on the type of nanoparticle core. Gel-core SLN were more stable than aqueous-core SLN, both during production and during shelf life. It has been shown that an increase in the core volume is possible for gel-core SLN during their preparation. The hydrodynamic diameter of gelcore SLN formulated in the absence and presence of Bovine serum albumin was ca. 200 nm. To determine the encapsulation efficiency (EE) and in vitro release profile, two model compounds, i.e. hydrophilic dye (Methylene blue) and fluorescent probe (Rhodamine B) have been used. It has been shown that EE depends on the type of nanoparticles. EE of the Rhodamine B-loaded SLN was recorded between 80-90%, for both gel-core and aqueous-core SLN. The release of Rhodamine D from gel-core SLN was slower than that from aqueous-core SLN. The release profile was shown to be dependent on the swelling of the core of SLN. Conclusion: The optimized SLN formulation proposed in this study (with the internal gel phase composed of 0.2% Carbopol 971) was found to be more stable over time, depicting lower polydispersity index and slower release, than the aqueouscore SLN. Refereed/Peer-reviewed

Published
2016

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