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3. Linfoma folicular: evaluación de índices pronósticos, variables clínicas y metabólicas al diagnóstico como predictores de progresión de enfermedad antes de los 2 años de iniciada la inmunoquimioterapia (POD24).

Author

Penalba, R., Fiad, L., Otero, V., Korin, J, Pavlovsky, Miguel Arturo, Mahuad, C., Arizo, A., Pavlovsky, Astrid, Courreges, V., Rodriguez, A., Trucco, J., Pereyra, P., Gilli, V., Gomez, M.S., Macchiavello, E., Masachessi, N., Marquez, M., Arriola, J., Cristaldo, N., Kalmus, E., Villarreal, P., Alfonso, G., Gonzalez Mercado, F., Vallejo, R., Enrrique, M., Melillo, L., Fernandez, D., Cugliari, María Silvana, Zerga, Marta, Sackmann, Federico, Penalba, R., Fiad, L., Otero, V., Korin, J, Pavlovsky, Miguel Arturo, Mahuad, C., Arizo, A., Pavlovsky, Astrid, Courreges, V., Rodriguez, A., Trucco, J., Pereyra, P., Gilli, V., Gomez, M.S., Macchiavello, E., Masachessi, N., Marquez, M., Arriola, J., Cristaldo, N., Kalmus, E., Villarreal, P., Alfonso, G., Gonzalez Mercado, F., Vallejo, R., Enrrique, M., Melillo, L., Fernandez, D., Cugliari, María Silvana, Zerga, Marta, and Sackmann, Federico

Abstract

Follicular lymphoma is an indolent lymphoma with potential relapses in the course of its evolution. In the last few years, new therapeutic strategies have improved patient ́s survival. However, a high risk subgroup progresses early with a shorter overall survival. Our primary objective is to report the inci-dence of POD24 and its impact on OS and, as a sec-ondary objective, to evaluate the association of the FLIPI 1, FLIPI 2 and PRIMA PI scores and the clin-ical-metabolic variables with the risk of a POD24 event. Three hundred and thirty-two patients were included, 46 patients (13.8%) with a POD24 event. Factors independently associated with greater prob-ability of a POD24 event were: presence of B symp-toms (OR 2.09) and elevated LDH (OR 1.27). In this study we report a significant difference in OS between POD24 vs NO POD24 (at 60 months, 63 vs 95% with p <0.001) reinforcing the POD24 impact as a negative prognostic factor. Despite being a retrospective study and the limited number of patients, we report local data not available to date. New clinical and/or biological markers will be necessary to identify the subgroup with POD24 risk, which could benefit from an adapted therapy., El linfoma folicular es un linfoma indolente con re-caídas potenciales en el curso de su evolución. En los últimos años nuevas estrategias terapéuticas han mejorado la sobrevida de los pacientes. Sin embargo, un subgrupo de alto riesgo progresa en forma temprana con una menor sobrevida global (SG). Nuestro objetivo primario es reportar la incidencia de POD24 y su impacto en SG y, como objetivo secundario, evaluar la asociación de los índices FLIPI 1, FLIPI 2 y PRIMA PI y las variables clíni-co-metabólicas con el riesgo de evento POD24. Se incluyeron 332 pacientes, 46 pacientes (13,8%) con evento POD24. Los factores asociados en forma in-dependiente a POD24 fueron: presencia de síntomas B (OR 2.09) y LDH elevada (OR 1.27). En este estu-dio reportamos diferencia significativa en SG entre POD24 vs NO POD24 (a 60 meses, 63 vs 95% con p <0.001) reforzando el impacto de POD24 como factor pronóstico negativo. A pesar de tratarse de un estudio retrospectivo y de número limitado de pacientes, reportamos datos locales no disponibles a la fecha. Serán necesarios nuevos marcadores clínicos y/o biológicos que permitan identificar el subgrupo con riesgo POD24 y que podría beneficiarse de una terapia adaptada.

Published
2022

9. The European Crowdfunding Service Providers Regulation and the Future of Marketplace Lending and Investing in Europe: the ‘Crowdfunding Nature’ Dilemma

Author

Macchiavello, E.

Subjects
Banking regulation, investment services, payment services, peer-to-peer lending, crowdfunding, FinTech, MiFID II, Prospectus, regulatory arbitrage, European Crowdfunding Services Regulation, ICOs, Brexit, bulletin board, secondary markets, prudential requirements, disclosure, know-your-customer, secondary markets, crowdfunding, Banking regulation, Prospectus, investment services, payment services, prudential requirements, FinTech, ICOs, MiFID II, bulletin board, European Crowdfunding Services Regulation, Brexit, disclosure, know-your-customer, peer-to-peer lending, regulatory arbitrage
Published
2021

16. Fintech and Alternative Finance in the CMU. The Regulation of Marketplace Investing

Author

Ferrarini, G., Macchiavello, E., Busch, D., Avgouleas, E., Busch, D., Avgouleas, E., and Ferrarini, G.

Subjects
crowdfunding, fintech, functional approach, Onderneming en Financieel Recht, Financial Markets and Supervision (Regulatory), Oxford EU Financial Regulation Series
Abstract

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Published
2018

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