692 results on '"Macchiarulo, Antonio"'
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2. Optimization of potent, broad-spectrum, and specific anti-influenza compounds targeting RNA polymerase PA-PB1 heterodimerization
3. Atypical enantioseparation of a non-ionic form of allantoin with Cinchona alkaloid-based zwitterionic chiral stationary phases
4. Natural cellulosic biofunctional textiles from onion (Allium cepa L.) skin extracts: A sustainable strategy for skin protection
5. Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum antiviral activity
6. THU-316 Farnesoid X receptor agonist INT-787 exhibits high intestinal localization
7. Development of 3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-sulfate sodium salt (INT-767): Process optimization, synthesis and characterization of metabolites
8. Positive allosteric modulation of indoleamine 2,3- dioxygenase 1 restrains neuroinflammation
9. Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism
10. Optimized one-pot derivatization and enantioseparation of cysteine: Application to the study of a dietary supplement
11. Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selective modulators (SAhRMs) versus rapidly metabolized ligands (RMAhRLs)
12. Computational studies in enantioselective liquid chromatography: Forty years of evolution in docking- and molecular dynamics-based simulations
13. Laboratory-Scale Semipreparative Enantioresolution of Phenylethanolic-Azole Heme Oxygenase-1 Inhibitors
14. 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
15. Aryl hydrocarbon receptor control of a disease tolerance defence pathway
16. Epacadostat stabilizes the apoform of IDO1 and signals a protumorigenic pathway in human ovarian cancer cells.
17. The hope and hype of ellagic acid and urolithins as ligands of SARS-CoV-2 Nsp5 and inhibitors of viral replication
18. Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification
19. Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors
20. Fragment-based approach to identify IDO1 inhibitor building blocks
21. A back-door insight into the modulation of Src kinase activity by the polyamine spermidine
22. Combining Solid‐State NMR with Structural and Biophysical Techniques to Design Challenging Protein‐Drug Conjugates
23. Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7
24. Data from Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy
25. Supplementary Figures S1-9, Tables S1 and 2 from Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy
26. Stabilization of the Dimeric State of SARS-CoV-2 Main Protease by GC376 and Nirmatrelvir
27. Turning a Tumor Microenvironment Pitfall into Opportunity: Discovery of Benzamidoxime as PD-L1 Ligand with pH-Dependent Potency
28. 4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP)
29. Estimating the hydrophobicity extent of molecular fragments using reversed‐phase liquid chromatography
30. Environmentally Sustainable Achiral and Chiral Chromatographic Analysis of Amino Acids in Food Supplements
31. Scaffold hopping approach on the route to selective tankyrase inhibitors
32. Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy
33. The Combination of Molnupiravir with Nirmatrelvir or GC376 Has a Synergic Role in the Inhibition of SARS-CoV-2 Replication In Vitro
34. The Systems Biology of Transporters - Targeting the Regulatory System for Transporters (FXR/RXR)
35. Critical Assessment of a Structure-Based Screening Campaign for IDO1 Inhibitors: Tips and Pitfalls
36. Exploring the effect of PARP-1 flexibility in docking studies
37. Modulation of the Kynurine Pathway of Tryptophan Metabolism in Search for Neuroprotective Agents. Focus on Kynurenine-3-Hydroxylase
38. A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells
39. Distinct roles of immunoreceptor tyrosine‐based motifs in immunosuppressive indoleamine 2,3‐dioxygenase 1
40. Chiral mobile phase in ligand-exchange chromatography of amino acids: Exploring the copper(II) salt anion effect with a computational approach
41. Fitting the complexity of GPCRs modulation into simple hypotheses of ligand design
42. Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists
43. Biological Evaluation of New Thienopyridinium and Thienopyrimidinium Derivatives as Human Choline Kinase Inhibitors
44. PROTACs bearing piperazine-containing linkers: what effect on their protonation state?
45. Development of 3α,7α-Dihydroxy-6α-ethyl-24-nor-5b-Cholan-23-Sulfate Sodium Salt (INT-767): Process Optimization, Synthesis and Characterization of Metabolites
46. Extending SAR of bile acids as FXR ligands: Discovery of 23- N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine
47. Indoleamine 2,3‐dioxygenase 1 (IDO1): an up‐to‐date overview of an eclectic immunoregulatory enzyme.
48. Computational studies for the elucidation of the enantiomer elution order of amino acids in chiral ligand-exchange chromatography
49. One Key and Multiple Locks: Substrate Binding in Structures of Tryptophan Dioxygenases and Hydroxylases
50. Quantum mechanics/molecular mechanics (QM/MM) modeling of the irreversible transamination of l-kynurenine to kynurenic acid: The round dance of kynurenine aminotransferase II
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