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Your search keyword '"Macchia P.E."' showing total 12 results
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12 results on '"Macchia P.E."'

5. Flavor test in patients with chronic kidney disease

Author

Nettore, I.C., primary, Salomone, E., additional, Lonardo, M.S., additional, Palatucci, G., additional, Maione, L., additional, Franchini, F., additional, Di Lauro, T., additional, Di Martino, R., additional, Aurino, L., additional, Rubino, R., additional, Colao, A., additional, Guida, B., additional, and Macchia, P.E., additional

Published
2020
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6. Selenium supplementation modulates apoptotic processes in thyroid follicular cells

Author

Nettore I.C., De Nisco E., Desiderio S., Passaro C., Maione L., Negri M., Albano L., Pivonello R., Pivonello C., Portella G., Ungaro P., Colao A., and Macchia P.E.

Subjects
endocrine system, Selenium, Hashimoto's thyroiditis, Apoptosis, Autoimmunity
Abstract

Selenium (Se) is an essential micronutrient modulating several physiopathological processes in the human body. The aim of the study is to characterize the molecular effects determined by Se-supplementation in thyroid follicular cells, using as model the well-differentiated rat thyroid follicular cell line FRTL5. Experiments have been performed to evaluate the effects of Se on cell growth, mortality and proliferation and on modulation of pro- and antiapoptotic pathways. The results indicate that Se-supplementation improves FRTL5 growth rate. Furthermore, Se reduces the proportion of cell death and modulates both proapoptotic (p53 and Bim) and antiapoptotic (NF-kB and Bcl2) mRNA levels. In addition, incubation with high doses of Na-Se might prevent the ER-stress apoptosis induced by tunicamycin, as assessed by membrane integrity maintenance, reduction in caspase 3/7 activities, and reduction in Casp-3 and PARP cleavage. Taken together, these results provide molecular evidences indicating the role of Se supplementation on cell death and apoptosis modulation in thyroid follicular cells. These observations may be useful to understand the effects of this micronutrient on the physiopathology of the thyroid gland.

Published
2017

9. Thyroid function and effect of aging in combined hetero/homozygous mice deficient in thyroid hormone receptors alpha and beta genes

Author

Weiss, R.E., Chassande, Olivier, Koo, E.K., Macchia, P.E., Cua, K., Samarut, Jacques, Refetoff, S., ProdInra, Migration, Unité mixte de recherche biologie moléculaire de la cellule, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-École normale supérieure - Lyon (ENS Lyon), and École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2002

11. Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH

Author

Acampora, D., primary, Mazan, S., additional, Tuorto, F., additional, Avantaggiato, V., additional, Tremblay, J.J., additional, Lazzaro, D., additional, di Carlo, A., additional, Mariano, A., additional, Macchia, P.E., additional, Corte, G., additional, Macchia, V., additional, Drouin, J., additional, Brulet, P., additional, and Simeone, A., additional

Published
1998
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