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2. Heart transplantation and biomarkers : a review about their usefulness in clinical practice

Author

Martini, L., Mandoli, G.E., Pastore, M.C., Pagliaro, A., Bernazzali, S., Maccherini, M., Henein, Michael Y., Cameli, M., Martini, L., Mandoli, G.E., Pastore, M.C., Pagliaro, A., Bernazzali, S., Maccherini, M., Henein, Michael Y., and Cameli, M.

Abstract

Advanced heart failure (AdvHF) can only be treated definitively by heart transplantation (HTx), yet problems such right ventricle dysfunction (RVD), rejection, cardiac allograft vasculopathy (CAV), and primary graft dysfunction (PGD) are linked to a poor prognosis. As a result, numerous biomarkers have been investigated in an effort to identify and prevent certain diseases sooner. We looked at both established biomarkers, such as NT-proBNP, hs-troponins, and pro-inflammatory cytokines, and newer ones, such as extracellular vesicles (EVs), donor specific antibodies (DSA), gene expression profile (GEP), donor-derived cell free DNA (dd-cfDNA), microRNA (miRNA), and soluble suppression of tumorigenicity 2 (sST2). These biomarkers are typically linked to complications from HTX. We also highlight the relationships between each biomarker and one or more problems, as well as their applicability in routine clinical practice.

Published
2024
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6. Echocardiographic reference ranges for non-invasive myocardial work indices in heart transplant patients

Author

Landra, F, primary, Martini, L, additional, Tanzi, L, additional, Fusi, C, additional, Barilli, M, additional, Sciaccaluga, C, additional, Diviggiano, E, additional, Focardi, M, additional, D'ascenzi, F, additional, Bernazzali, S, additional, Maccherini, M, additional, Valente, S, additional, Cameli, M, additional, and Mandoli, G E, additional

Published
2023
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9. ADONHERS (Aged DONor HEart Rescue by Stress echo) protocol for heart donation from marginal donor hearts: monocentric retrospective study on recipients survival after 10-year follow-up

Author

Mandoli, G E, primary, Barilli, M, additional, Soviero, D, additional, Ghionzoli, N, additional, Maccherini, M, additional, Bernazzali, S, additional, Natali, B, additional, Cavigli, L, additional, D'Ascenzi, F, additional, Focardi, M, additional, Pastore, M C, additional, Valente, S, additional, and Cameli, M, additional

Published
2022
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19. Factors Influencing Access to Transplant, Waitlist Mortality, and Post-Transplant Survival in the Italian National Heart Transplant Database

Author

Frigerio, M, Varrenti, M, Santolamazza, C, Bernasconi, D, Costa, A, Oliveti, A, Puoti, F, Bottio, T, Gerosa, G, Russo, C, Giannattasio, C, Tursi, V, Livi, U, Maiello, C, Amarelli, C, Potena, L, Martin Suarez, S, Boffini, M, Pace Napoleone, C, Clemenza, F, Musumeci, F, Maccherini, M, Faggian, G, Pellegrini, C, Terzi, A, Tramontin, C, De Angelis, D, Milano, A, Valsecchi, M, Frigerio, M., Varrenti, M., Santolamazza, C., Bernasconi, D. P., Costa, A. Nanni, Oliveti, A., Puoti, F., Bottio, T., Gerosa, G., Russo, C. F., Giannattasio, C., Tursi, V., Livi, U., Maiello, C., Amarelli, C., Potena, L., Martin Suarez, S., Boffini, M., Pace Napoleone, C., Clemenza, F., Musumeci, F., Maccherini, M., Faggian, G., Pellegrini, C., Terzi, A., Tramontin, C., De Angelis, D., Milano, A. D., Valsecchi, M., Frigerio, M, Varrenti, M, Santolamazza, C, Bernasconi, D, Costa, A, Oliveti, A, Puoti, F, Bottio, T, Gerosa, G, Russo, C, Giannattasio, C, Tursi, V, Livi, U, Maiello, C, Amarelli, C, Potena, L, Martin Suarez, S, Boffini, M, Pace Napoleone, C, Clemenza, F, Musumeci, F, Maccherini, M, Faggian, G, Pellegrini, C, Terzi, A, Tramontin, C, De Angelis, D, Milano, A, Valsecchi, M, Frigerio, M., Varrenti, M., Santolamazza, C., Bernasconi, D. P., Costa, A. Nanni, Oliveti, A., Puoti, F., Bottio, T., Gerosa, G., Russo, C. F., Giannattasio, C., Tursi, V., Livi, U., Maiello, C., Amarelli, C., Potena, L., Martin Suarez, S., Boffini, M., Pace Napoleone, C., Clemenza, F., Musumeci, F., Maccherini, M., Faggian, G., Pellegrini, C., Terzi, A., Tramontin, C., De Angelis, D., Milano, A. D., and Valsecchi, M.

Published
2019

21. Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement

Author

Stricagnoli, M., primary, Sciaccaluga, C., additional, Mandoli, G. E., additional, Rizzo, L., additional, Sisti, N., additional, Aboumarie, H. S., additional, Benfari, G., additional, Maritan, L., additional, Tsioulpas, C., additional, Bernazzali, S., additional, Maccherini, M., additional, Natali, B. M., additional, Focardi, M., additional, D’Ascenzi, F., additional, Lisi, M., additional, Valente, S., additional, Mondillo, S., additional, and Cameli, M., additional

Published
2021
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22. Heart transplantation and antibody-mediated rejection: role of myocardial strain as an early marker of cardiac dysfunction in patients with anti-HLA antibody

Author

Sciaccaluga, C, primary, Natali, B.M, additional, Mandoli, G.E, additional, Sisti, N, additional, Righini, F.M, additional, Menci, D, additional, D'Errico, A, additional, Benfari, G, additional, D'Ascenzi, F, additional, Cavigli, L, additional, Focardi, M, additional, Valente, S, additional, Bernazzali, S, additional, Maccherini, M, additional, and Cameli, M, additional

Published
2021
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26. Premessa

Author

Pezzuto, L. and Maccherini, M.

Published
2021

39. Left atrial strain as a pre-operative prognostic marker for patients with severe primary mitral regurgitation

Author

Mandoli, G.E, primary, Pastore, M.C, additional, Benfari, G, additional, Maccherini, M, additional, Lisi, G, additional, Cameli, P, additional, Lisi, M, additional, Lisi, E, additional, Tsioulpas, C, additional, Carrucola, C, additional, Vigna, M, additional, Montesi, G, additional, Valente, S, additional, Mondillo, S, additional, and Cameli, M, additional

Published
2020
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47. Prefazione

Author

Maccherini, M

Published
2018

48. Optimizing the Safety Profile of Everolimus by Delayed Initiation in De Novo Heart Transplant Recipients: Results of the Prospective Randomized Study EVERHEART

Author

Potena, L., Pellegrini, C., Grigioni, F., Amarelli, C., Livi, U., Maccherini, M., Masciocco, G., Faggian, G., Lilla Della Monica, P., Gerosa, G., Marraudino, N., Corda, M., Boffini, M., De Santo, L. S., Tona, F., Poggio, D., Savini, C., Ambrogi, F., Bernazzali, S., D'Armini, A. M., Mattiucci, G., Rinaldi, M., Ribezzo, M., Porcu, M., Musumeci, F., Gambino, A., Maiello, C., Frigerio, M., Guzzi, G., Forni, A., and Capone, G.

Subjects
Male, medicine.medical_specialty, Pleural effusion, medicine.medical_treatment, 030204 cardiovascular system & hematology, 030230 surgery, Pericardial effusion, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Cumulative incidence, Everolimus, Prospective Studies, Prospective cohort study, Heart transplantation, Transplantation, business.industry, Original Clinical Science—General, medicine.disease, Surgery, Discontinuation, Heart Transplantation, Female, Immunosuppressive Agents, business, medicine.drug
Abstract

Background Although everolimus potentially improves long-term heart transplantation (HTx) outcomes, its early postoperative safety profile had raised concerns and needs optimization. Methods This 6-month, open-label, multicenter randomized trial was designed to compare the cumulative incidence of a primary composite safety endpoint comprising wound healing delays, pericardial effusion, pleural effusion needing drainage, and renal insufficiency events (estimated glomerular filtration rate ≤30/mL/min per 1.73 m2) in de novo HTx recipients receiving immediate everolimus (EVR-I) (≤144 hours post-HTx) or delayed everolimus (EVR-D) (4-6 weeks post-HTx with mycophenolate mofetil as a bridge) with reduced-dose cyclosporine A. Cumulative incidence of biopsy-proven rejection ≥ 2R, rejection with hemodynamic compromise, graft loss, or death was the secondary composite efficacy endpoint. Results Overall, 181 patients were randomized to the EVR-I (n = 89) or EVR-D (n = 92) arms. Incidence of primary safety endpoint was higher for EVR-I than EVR-D arm (44.9% vs 32.6%; P = 0.191), mainly driven by a higher rate of pericardial effusion (33.7% vs 19.6%; P = 0.04); wound healing delays, acute renal insufficiency events, and pleural effusion occurred at similar frequencies in the study arms. Efficacy failure was not significantly different in EVR-I arm versus EVR-D arm (37.1% vs 28.3%; P = 0.191). Three patients in the EVR-I arm and 1 in the EVR-D arm died. Incidence of clinically significant adverse events leading to discontinuation was higher in EVR-I arm versus EVR-D arm (P = 0.02). Conclusions Compared with immediate initiation, delayed everolimus initiation appeared to provide a clinically relevant early safety benefit in de novo HTx recipients, without compromising efficacy., The 6-month, open-label, multicenter randomized trial is designed to compare primary safety endpoints in de novo heart transplantation and delayed everolimus initiation seems to provide a clinically relevant early safety benefit compared to immediate initiation without compromising efficacy. Supplemental digital content is available in the text.

Published
2018

49. Factors Influencing Access to Transplant, Waitlist Mortality, and Post-Transplant Survival in the Italian National Heart Transplant Database

Author

Frigerio, M., primary, Varrenti, M., additional, Santolamazza, C., additional, Bernasconi, D.P., additional, Costa, A. Nanni, additional, Oliveti, A., additional, Puoti, F., additional, Bottio, T., additional, Gerosa, G., additional, Russo, C.F., additional, Giannattasio, C., additional, Tursi, V., additional, Livi, U., additional, Maiello, C., additional, Amarelli, C., additional, Potena, L., additional, Martin Suarez, S., additional, Boffini, M., additional, Pace Napoleone, C., additional, Clemenza, F., additional, Musumeci, F., additional, Maccherini, M., additional, Faggian, G., additional, Pellegrini, C., additional, Terzi, A., additional, Tramontin, C., additional, De Angelis, D., additional, Milano, A.D., additional, and Valsecchi, M., additional

Published
2019
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