182 results on '"Macarri G"'
Search Results
2. T03.02.8 DUODENOSCOPE-RELATED INFECTIONS: AN ITALIAN PICK IN 2019
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Fugazza, A., primary, Anderloni, A., additional, Lamonaca, L., additional, Craviotto, V., additional, Spadaccini, M., additional, Maselli, R., additional, Carrara, S., additional, Di Leo, M., additional, Galtieri, P.A., additional, Pellegatta, G., additional, Ferrara, E.C., additional, Alvisi, C., additional, Aragona, G., additional, Ayoubi, M., additional, Bassi, M., additional, Benedetti, A., additional, Beretta, P., additional, Berni Canani, M., additional, Calcara, C., additional, Cambareri, A., additional, Camellini, L., additional, Canfora, M.L., additional, Cantù, P., additional, Cengia, G., additional, Cereatti, F., additional, Costamagna, G., additional, Cugia, L., additional, De Angelis, C., additional, De Bellis, M., additional, De Grazia, F., additional, Del Vecchio Blanco, G., additional, Di Giulio, E., additional, Diamantis, G., additional, Dinelli, M., additional, Fabbri, C., additional, Feliciangeli, G., additional, Gabrielli, A., additional, Gambitta, P., additional, Gullotta, R., additional, Lauri, A., additional, Leoni, P., additional, Luigiano, C., additional, Macarri, G., additional, Manes, G., additional, Manfredi, G., additional, Manno, M., additional, Mantovani, N., additional, Mariani, A., additional, Masci, E., additional, Missale, G., additional, Mosca, P., additional, Mussetto, A., additional, Mutignani, M., additional, Occhipinti, P., additional, Paganelli, M., additional, Radaelli, F., additional, Salerno, R., additional, Traina, M., additional, Tringali, A., additional, and Venezia, G., additional
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- 2020
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3. OC.01.3 EUS-GUIDED TISSUE ACQUISITION IN CHRONIC PANCREATITIS: DIFFERENTIAL DIAGNOSIS BETWEEN PANCREATIC CANCER AND PSEUDOTUMORAL MASSES USING EUS-FINE NEEDLE ASPIRATION OR CORE BIOPSY
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Grassia, R., primary, Imperatore, N., additional, Capone, P., additional, Cereatti, F., additional, Forti, E., additional, Antonini, F., additional, Tanzi, G.P., additional, Martinotti, M., additional, Buffoli, F., additional, Mutignani, M., additional, Macarri, G., additional, Manes, G., additional, Vecchi, M., additional, and De Nucci, G., additional
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- 2020
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4. EUS-GUIDED TISSUE ACQUISITION IN CHRONIC PANCREATITIS: DIFFERENTIAL DIAGNOSIS BETWEEN PANCREATIC CANCER AND PSEUDOTUMORAL MASSES USING EUS-FINE NEEDLE ASPIRATION OR CORE BIOPSY
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Grassia, R, additional, Imperatore, N, additional, Capone, P, additional, Cereatti, F, additional, Forti, E, additional, Antonini, F, additional, Conti, CB, additional, Tanzi, GP, additional, Martinotti, M, additional, Buffoli, F, additional, Mutignani, M, additional, Macarri, G, additional, Manes, G, additional, Vecchi, M, additional, and DeNucci, G, additional
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- 2020
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5. DUODENOSCOPE-RELATED INFECTIONS: AN ITALIAN PICK IN 2019
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Fugazza, A, additional, Lamonaca, L, additional, Alvisi, C, additional, Aragona, G, additional, Ayoubi, M, additional, Bassi, M, additional, Benedetti, A, additional, Beretta, P, additional, Canani, MB, additional, Calcara, C, additional, Cambareri, A, additional, Camellini, L, additional, Canfora, ML, additional, Cantù, P, additional, Cengia, G, additional, Cereatti, F, additional, Costamagna, G, additional, Cugia, L, additional, Angelis, CD, additional, Grazia, FD, additional, Blanco, GDV, additional, Giulio, ED, additional, Diamantis, G, additional, Dinelli, M, additional, Fabbri, C, additional, Feliciangeli, G, additional, Gabbrielli, A, additional, Gambitta, P, additional, Luigiano, C, additional, Macarri, G, additional, Manes, G, additional, Manfredi, G, additional, Manno, M, additional, Mantovani, N, additional, Mariani, A, additional, Masci, E, additional, Missale, G, additional, Mosca, P, additional, Mussetto, A, additional, Mutignani, M, additional, Occhipinti, P, additional, Paganelli, M, additional, Parodi, MC, additional, Radaelli, F, additional, Salerno, R, additional, Traina, M, additional, Tringali, A, additional, Venezia, G, additional, Anderloni, A, additional, and Repici, A, additional
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- 2020
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6. Effect of cyanidin 3- O-β-glucopyranoside on hepatic stellate cell proliferation and collagen synthesis induced by oxidative stress
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Bendia, E., Benedetti, A., Baroni, G.S., Candelaresi, C., Macarri, G., Trozzi, L., and Di Sario, A.
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- 2005
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7. The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen α1(I), TIMP-1 and MMP-2
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Di Sario, A., Bendia, E., Macarri, G., Candelaresi, C., Taffetani, S., Marzioni, M., Omenetti, A., Minicis, S. De, Trozzi, L., and Benedetti, A.
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- 2004
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8. HIGH DIAGNOSTIC ADEQUACY AND ACCURACY OF THE NEW 20G PROCORE NEEDLE FOR EUS-GUIDED TISSUE ACQUISITION: RESULTS OF A LARGE MULTICENTRE RETROSPECTIVE STUDY
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Fabbri, C, additional, Fornelli, A, additional, Fuccio, L, additional, Giovanelli, S, additional, Tarantino, I, additional, Antonini, F, additional, Liotta, R, additional, Frazzoni, L, additional, Gusella, P, additional, La Marca, M, additional, Barresi, L, additional, Macarri, G, additional, Traina, M, additional, De Biase, D, additional, Fiorino, S, additional, Jovine, E, additional, Larghi, A, additional, and Cennamo, V, additional
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- 2019
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9. P.03.15 APPLICABILITY OF A CHECKLIST FOR THE DIAGNOSIS AND TREATMENT OF SEVERE EXOCRINE PANCREATIC INSUFFICIENCY (EPI). PRELIMINARY RESULTS OF AN EPI ITALIAN REGISTRY (EPITALY)
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Pezzilli, R., primary, Capurso, G., additional, Carroccio, A., additional, Costamagna, G., additional, Di Leo, A., additional, Falconi, M., additional, Frulloni, L., additional, Macarri, G., additional, Salacone, P., additional, and Zerbi, A., additional
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- 2019
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10. P.05.1 PANCREATIC CANCER AND PSEUDOTUMORAL MASSES IN CHRONIC PANCREATITIS: DIAGNOSTIC ACCURACY OF ENDOSCOPIC ULTRASOUND AND FINE NEEDLE BIOPSY (EUS-FNB)
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Grassia, R., primary, Imperatore, N., additional, Capone, P., additional, Cereatti, F., additional, Forti, E., additional, Antonini, F., additional, Tanzi, G.P., additional, Martinotti, M., additional, Buffoli, F., additional, Mutignani, M., additional, Macarri, G., additional, Manes, G., additional, Vecchi, M., additional, and De Nucci, G., additional
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- 2019
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11. C09/09 HEPATIC STELLATE CELLS ACTIVATION AND LIVER FIBROSIS ARE INDUCED BY NECROINFLAMMATORY INJURY AND NOT RELATED TO VIRAL LOAD AND GENOTYPE IN CHRONIC HEPATITIS C.
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Baroni, G. Svegliati, Manzin, A., Pastorelli, A., Benedetti, A., Solforosi, L., D' Ambrosio, L., Saccomanno, S., Brunelli, E., Macarri, G., Jezequel, A. M., Clementi, M., and Orlandi, F.
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- 1997
12. C01/007 DYNAMICS OF HCV REPLICATION DURING PRIMARY INFECTION AND SELECTION OF VIRAL QUASISPECIES
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Manzin, A., Solforosi, L., Petrelli, E., Macarri, G., and Clementi, M.
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- 1996
13. Primary biliary cirrhosis: modalities of injury and death in biliary epithelium
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Marucci, L., Ugili, L., Macarri, G., Feliciangeli, G., Bendia, E., Jezequel, A.M., Orlandi, F., and Benedetti, A.
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- 2001
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14. Enteral nutrition by percutaneous endoscopic gastrostomy
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Brunelli, E., Contucci, S., Macarri, G., Curto, R., and Orland, F.
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- 1993
15. Confirmatory factor analysis of the Patient Assessment of Constipation-Symptoms (PAC-SYM) among patients with chronic constipation
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Neri L, Conway PM, Basilisco G, Altomare DF, Annese V, Badiali D, Bassotti G, Battaglia E, Bazzocchi G, Bellini M, Bendia E, Benini L, Biscaglia G, Biviano I, Bocchini R, Bonfrate L, Bonventre S, Bossa F, Brandimarte G, Cannizzaro R, Cicala M, Cipolletta L, Clara V, Cogliandro R, Comandini G, Corazziari E, Crotta S, CUOMO, ROSARIO, D'Alba L, De Giorgi F, Del Piano M, Di Fonzo M, Di Mario Francesco, Di Stefano M, D'Onofrio V, Efthymakis K, Fiore P, Fortuna M, Fries W, Gaetani E, Galeazzi F, Gasbarrini A, Geccherle' A, Giangregorio F, Girardi L, Grassini M, Groppo M, Guarnieri G, Iovino P, Lo Cascio M, Lolli R, Luzza F, Macarri G, Marino M, Miraglia S, Monastra S, Neri MC, Neri M, Noris RA, Orselli S, Passaretti S, Paviotti A, Pazzi P, Pilotto A, Portincasa P, Ranaldo N, Ravelli P, Rogai F, Sablich R, Savarino V, Spinzi G, Stanghellini V, Tammaro L, Torresan F, Usai Satta P, Valle C., Neri, L, Conway, Pm, Basilisco, G, Stanghellini, V, Neri, L., Conway, P., Basilisco, G., Bonventre, S, Altomare, Df, Annese, V, Badiali, D, Bassotti, G, Battaglia, E, Bazzocchi, G, Bellini, M, Bendia, E, Benini, L, Biscaglia, G, Biviano, I, Bocchini, R, Bonfrate, L, Bossa, F, Brandimarte, G, Cannizzaro, R, Cicala, M, Cipolletta, L, Clara, V, Cogliandro, R, Comandini, G, Corazziari, E, Crotta, S, Cuomo, Rosario, D'Alba, L, De Giorgi, F, Del Piano, M, Di Fonzo, M, Di Mario, Francesco, Di Stefano, M, D'Onofrio, V, Efthymakis, K, Fiore, P, Fortuna, M, Fries, W, Gaetani, E, Galeazzi, F, Gasbarrini, A, Geccherle', A, Giangregorio, F, Girardi, L, Grassini, M, Groppo, M, Guarnieri, G, Iovino, P, Lo Cascio, M, Lolli, R, Luzza, F, Macarri, G, Marino, M, Miraglia, S, Monastra, S, Neri, Mc, Neri, M, Noris, Ra, Orselli, S, Passaretti, S, Paviotti, A, Pazzi, P, Pilotto, A, Portincasa, P, Ranaldo, N, Ravelli, P, Rogai, F, Sablich, R, Savarino, V, Spinzi, G, Tammaro, L, Torresan, F, Usai Satta, P, and Valle, C.
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Adult ,Male ,medicine.medical_specialty ,Abdominal pain ,Constipation ,Constipation severity ,Chronic constipation ,Chronic non-organic constipation ,Quality of life ,Chronic Disease ,Female ,Humans ,Middle Aged ,Patient Care ,Quality of Life ,Reproducibility of Results ,Surveys and Questionnaires ,Factor Analysis, Statistical ,Public Health, Environmental and Occupational Health ,Medicine (all) ,Reproducibility of Result ,Internal medicine ,medicine ,Criterion validity ,Surveys and Questionnaire ,Settore MED/12 - Gastroenterologia ,business.industry ,Minimal clinically important difference ,Environmental and Occupational Health ,Settore MED/09 - MEDICINA INTERNA ,Statistical ,medicine.disease ,Confirmatory factor analysis ,Settore MED/18 - Chirurgia Generale ,Physical therapy ,Functional constipation ,Public Health ,medicine.symptom ,business ,Factor Analysis ,Human - Abstract
Background and aim: PAC-SYM is widely adopted to asses constipation severity. However, it has been validated in a small sample, few items have been included based on expert opinion and not on empirical grounds, and its factor structure has never been replicated. We aimed at evaluating the psychometric properties of PAC-SYM in patients with chronic constipation. Methods: We enrolled 2,203 outpatients with chronic constipation in two waves. We used wave I sample to test the psychometric properties of the PAC-SYM and wave II sample to cross-validate its factor structure, to assess criterion validity, responsiveness to clinical change, and its minimal clinically important difference. Results: Only a minority of patients reported any rectal tearing (38 %). Deletion of such item leads to a 11-item version (M:PAC-SYM). The remaining items in the rectal domain were moderately correlated with the stool domain. Exploratory factor analysis and confirmatory factor analysis revealed a bifactor structure with two subscales (stool and abdominal symptoms) and a general severity factor. The M:PAC-SYM demonstrated excellent reliability, moderate correlation with SF-12 and treatment satisfaction (r = 0.28–0.45), discrimination across Rome III criteria for functional constipation and abdominal pain, and responsiveness to clinical change (β = −0.49; ω 2 = 0.25). M:PAC-SYM minimal clinically important difference was 0.24. Conclusion: Our analysis shows that the rectal domain may not represent a relevant cluster of symptoms for patients with chronic constipation. We developed a modified version of the PAC-SYM which might better represent symptom severity of most patients seeking care in gastroenterology referral centers
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- 2014
16. EUS ELASTOGRAPHY STRAIN RATIO IN THE DIFFERENTIAL DIAGNOSIS OF GASTROINTESTINAL SUBEPITHELIAL LESIONS: PRELIMINARY RESULTS OF A MULTICENTER STUDY
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Antonini, F, additional, Fusaroli, P, additional, Frazzoni, L, additional, Belfiori, V, additional, Auriemma, F, additional, Rahal, D, additional, Serrani, M, additional, Lisotti, A, additional, Giorgini, S, additional, Fuccio, L, additional, Repici, A, additional, Macarri, G, additional, and Carrara, S, additional
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- 2018
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17. P.08.20 EUS ELASTOGRAPHY STRAIN RATIO IN THE DIFFERENTIAL DIAGNOSIS OF GASTROINTESTINAL SUBEPITHELIAL LESIONS: PRELIMINARY RESULTS OF A MULTICENTER STUDY
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Antonini, F., primary, Fusaroli, P., additional, Frazzoni, L., additional, Belfiori, V., additional, Auriemma, F., additional, Rahal, D., additional, Serrani, M., additional, Lisotti, A., additional, Giorgini, S., additional, Fuccio, L., additional, Repici, A., additional, Macarri, G., additional, and Carrara, S., additional
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- 2018
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18. P.04.9 ENDOSCOPIC ULTRASOUND FEATURES OF PARADUODENAL PANCREATITIS MIMICKING MALIGNANCY
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Antonini, F., primary, Manfredi, G., additional, Pezzilli, R., additional, Macarri, G., additional, and Buscarini, E., additional
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- 2018
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19. P.03.12 ENDOSUTURING IN COLONIC DEHISCENCES: A SAFE OPTION WITH LESS COMPLICATIONS
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De Minicis, S., primary, Belfiori, V., additional, Antonini, F., additional, Piergallini, S., additional, Marraccini, B., additional, Rossetti, P., additional, Traini, S., additional, Calcina, S., additional, and Macarri, G., additional
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- 2018
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20. Comparison of Two Dosing Regimens of Gabexate in The Prophylaxis of Post-Ercp Pancreatitis
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Masci E, Cavallini G, Mariani A, Frulloni L, Curioni S, Tittobello A, Uomo G, Costamagna G, Zambelli S, Macarri G, Innocenti P, Dragonetti C, Gabexate in Digestive Endoscopy Italian Group, TESTONI , PIER ALBERTO, Masci, E, Cavallini, G, Mariani, A, Frulloni, L, Testoni, PIER ALBERTO, Curioni, S, Tittobello, A, Uomo, G, Costamagna, G, Zambelli, S, Macarri, G, Innocenti, P, Dragonetti, C, and Gabexate in Digestive Endoscopy Italian, Group
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Male ,Pancreatic disease ,medicine.medical_treatment ,chemistry.chemical_compound ,Endoscopic Retrograde ,Reference Values ,Gabexate ,80 and over ,Prospective Studies ,Infusions, Intravenous ,Prospective cohort study ,Saline ,Pain Measurement ,Aged, 80 and over ,Cholangiopancreatography, Endoscopic Retrograde ,Gastroenterology ,Middle Aged ,Cholangiopancreatography ,Treatment Outcome ,Italy ,Anesthesia ,Acute Disease ,Chemoprophylaxis ,Acute pancreatitis ,Female ,Drug ,Intravenous ,Adult ,Infusions ,medicine.medical_specialty ,Adolescent ,Biliary Tract Diseases ,Placebo ,Risk Assessment ,Drug Administration Schedule ,Dose-Response Relationship ,Double-Blind Method ,medicine ,Humans ,Aged ,Dose-Response Relationship, Drug ,Hepatology ,business.industry ,Pancreatic Diseases ,medicine.disease ,Surgery ,Pancreatitis ,chemistry ,Follow-Up Studies ,business - Abstract
Objectives A continuous 13-h infusion of gabexate starting 30–90 min before endoscopic cholangiopancreatography (ERCP) can reduce postprocedural pancreatitis, the onset of which is generally observed within the first 6 h after ERCP. This study was designed to verify whether a 6.5-h infusion of gabexate was as effective as a 13-h infusion, at the same concentration, for reducing the incidence of post-ERCP pancreatitis (primary endpoint) and pancreatic hyperenzymemia and pain (secondary endpoints). Methods A total of 434 patients (201 male and 233 female; mean age 63.9 yr, range 18–96 yr) scheduled for ERCP were prospectively recruited in 25 Italian centers. Patients were randomized double-blind to two treatment groups. All subjects enrolled were first treated with a 500-mg continuous intravenous infusion of gabexate, starting 30 min before the endoscopic maneuvers and continuing up to 6.5 h after it. Over the next 6.5 h, 214 patients (group I) continued the infusion of gabexate (for a total of 1 g over 13 h) and 220 patients (group II) were given placebo (saline solution). Results The overall incidence of acute pancreatitis was 1.8% (eight patients), which included 1.4% in group I (three of 214 patients) and 2.2% in group II (five of 220 patients). Serum amylase and lipase values over time, peak levels of the two enzymes, pancreatic pain, and need for analgesics did not significantly differ in the two groups. Conclusions These results suggest that a 6.5-h infusion of gabexate (for a total of 500 mg) is not less effective than a 13 h infusion, with evident savings.
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- 2003
21. Italian consensus guidelines for chronic pancreatitis
- Author
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Frulloni, L, Falconi, M, Gabbrielli, A, Gaia, E, Graziani, R, Pezzilli, R, Uomo, G, Andriulli, A, Balzano, G, Benini, L, Calculli, L, Campra, D, Capurso, G, Cavestro, Gm, De Angelis, C, Ghezzo, L, Manfredi, R, Malesci, A, Mariani, A, Mutignani, M, Ventrucci, M, Zamboni, G, Amodio, A, Vantini, I, Bassi, C, Delle Fave, G, Capurso, Iv, Magarini, F, Albarello, L, Alfieri, S, Anti, M, Arcidiacono, P, Baiocchi, L, Berretti, D, Boraschi, P, Buscarini, E, Carroccio, A, Celebrano, Mr, Casadei, R, Chilovi, F, Conigliaro, R, Dall'Oglio, L, De Boni, M, De Pretis, G, Di Priolo, S, Di Sebastiano PL, Doglietto, Gb, Filauro, M, Frieri, G, Fuini, A, Loriga, P, Macarri, G, Manes, G, Massucco, P, Milani, S, Pasquali, Claudio, Pederzoli, P, Pietrangeli, M, Rocca, R, Russello, D, Siquini, W, Traina, M, Veneroni, L, Zilli, M, Italian Association for the Study of the Pancreas, Frulloni L, Falconi M, Gabbrielli A, Gaia E, Graziani R, Pezzilli R, Uomo G, Andriulli A, Balzano G, Benini L, Calculli L, Campra D, Capurso G, Cavestro GM, De Angelis C, Ghezzo L, Manfredi R, Malesci A, Mariani A, Mutignani M, Ventrucci M, Zamboni G, Amodio A, Vantini I, Italian Association for the Study of the Pancreas (AISP), Bassi C, Delle Fave G, Capurso IV, Magarini F, Albarello L, Alfieri S, Anti M, Arcidiacono P, Baiocchi L, Berretti D, Boraschi P, Buscarini E, Carroccio A, Celebrano MR, Casadei R, Chilovi F, Conigliaro R, Dall'Oglio L, De Boni M, De Pretis G, Di Priolo S, Di Sebastiano PL, Doglietto GB, Filauro M, Frieri G, Fuini A, Loriga P, Macarri G, Manes G, Massucco P, Milani S, Pasquali C, Pederzoli P, Pietrangeli M, Rocca R, Russello D, Siquini W, Traina M, Veneroni L, Zilli M, Zamboni G., Frulloni, L, Falconi, M, Gabbrielli, A, Gaia, E, Graziani, R, Pezzilli, R, Uomo, G, Andriulli, A, Balzano, G, Benini, L, Calculli, L, Campra, D, Capurso, G, Cavestro, Gm, De Angelis, C, Ghezzo, L, Manfredi, R, Malesci, A, Mariani, A, Mutignani, M, Ventrucci, M, Zamboni, G, Amodio, A, Vantini, I, Italian Association for the Study of the Pancreas, (AISP), Bassi, C, Delle Fave, G, Capurso, Iv, Magarini, F, Albarello, L, Alfieri, S, Anti, M, Arcidiacono, P, Baiocchi, L, Berretti, D, Boraschi, P, Carroccio, A, Celebrano, Mr, Casadei, R, Chilovi, F, Conigliaro, R, Dall'Oglio, L, De Boni, M, De Pretis, G, Di Priolo, S, Di Sebastiano, Pl, Doglietto, Gb, Filauro, M, Frieri, G, Fuini, A, Macarri, G, Manes, G, Massucco, P, Milani, S, Pasquali, C, Pederzoli, P, Pietrangeli, M, Rocca, R, Russello, D, Siquini, W, Traina, M, Veneroni, L, Zilli, M, and Zamboni, G.
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medicine.medical_specialty ,complications ,pancreatic supplements ,diagnostic imaging ,pancreatitis ,MEDLINE ,cholangiopancreatography ,chronic ,endoscopic retrograde ,pain ,quality of life ,radiography ,sphincterotomy ,steatorrhea ,surgery ,therapy ,ultrasonography ,Appropriate use ,guidelines ,chronica pancreatitis ,Pancreatitis, Chronic ,Pancreatitis, chronic ,Complications ,Surgery ,Medical imaging ,Medicine ,Humans ,Pancreatic stones ,Intensive care medicine ,Surgical treatment ,Hepatology ,medicine.diagnostic_test ,business.industry ,Pancreatitis ,Radiography ,Therapy ,Ultrasonography ,Cholangiopancreatography ,Sphincterotomy ,Diagnostic imaging ,Pain ,Quality of life ,Steatorrhea ,Pancreatic supplements ,Gastroenterology ,medicine.disease ,Endoscopy ,Pancreatic pain ,Italy ,CHRONIC PANCREATITIS ,Radiology ,business - Abstract
This paper gives practical guidelines for diagnosis and treatment of chronic pancreatitis. Statements have been elaborated by working teams of experts, by searching for and analysing the literature, and submitted to a consensus process by using a Delphi modified procedure. The statements report recommendations on clinical and nutritional approach, assessment of pancreatic function, treatment of exocrine pancreatic failure and of secondary diabetes, treatment of pain and prevention of painful relapses. Moreover, the role of endoscopy in approaching pancreatic pain, pancreatic stones, duct narrowing and dilation, and complications was considered. Recommendations for most appropriate use of various imaging techniques and of ultrasound endoscopy are reported. Finally, a group of recommendations are addressed to the surgical treatment, with definition of right indications, timing, most appropriate procedures and techniques in different clinical conditions and targets, and clinical and functional outcomes following surgery. © 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. Keywords: Pancreatitis, chronic; Complications; Surgery; Radiography; Therapy; Ultrasonography; Cholangiopancreatography
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- 2010
22. Surgical management of acute pancreatitis in Italy: lessons from a prospective multicentre study
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De Rai, Paolo, Zerbi, Alessandro, Castoldi, Laura, Bassi, Claudio, Frulloni, Luca, Uomo, Generoso, Gabbrielli, Armando, Pezzilli, Raffaele, Cavallini, Giorgio, Di Carlo, Valerio, Agugiaro, S., Turri, L., Bartoli, A., Barberini, F., Cavazzoni, G., Bartolo, F., Della Papa, D., Bassi, N., Massani, M., Benedetti, A., Macarri, G., Piergallini, L., Briani, G., Bartolasi, L., Bugnano, L., Buonanno, G. M., Esposito, C., Cordovana, A., Cavina, E., Seccia, M., Lippolis, P., Musco, B., Barletta, M., Chilovi, E., De Guelfi, A., Chirletti, P., Caronna, R., Scozzafava, S., Cardi, M., Cirino, E., Buffone, A., Colangelo, E., Caracino, V., Cortese, F., Casentini, A., Costamagna, G., Trincali, A., Curzio, M., Clivio, S., Segato, S., D'Alessandro, A., Ambrosiani, V., D'Ambrosio, B., Chiodo, C., Dicillo, M., Reale, L., Grandolfo, A., Fabbrucci, P., Bruscino, A., Mugnaini, P., Ferrarese, S., Ugenti, I., Forte, G. B., Rocco, P., Franzè, A., Bertelè, A., Sereni, G., Friedman, Daniele, Mariani, L., Morelli, F., Gai, V., Antro, C., Garcea, D., Gardini, A., Lucci, E., Giulianotti, P. C., Sbrana, F., Balestracci, T., Giulini, S. M., Pellizzari, A., Ronconi, M., Cimaschi, S., Grassini, M., Lacignola, S., Calandro, L., Mazzitelli, L., Costarella, S. M., Egidio, A., Mello Teggia, P., Stefano, E., Cassini, P., Modica, G., Lupo, F., Giraci, G., Mosca, F., Del Chiaro, M., Mosella, G., Benassai, G., Nanni, M., D'Aristotile, A., Negro, P., Pirazzoli, A., Rabitti, P. G., Romano, C., Gerardi, G., Troianello, B., Russello, D., Di Stefano, A., Avelli, S., Salval, N., Bellini, N., Scalon, P., Staudacher, C., Parolini, D., Strazzabosco, M., Signorelli, S., Tedeschi, U., Testoni, P. A., Masci, E., Mariani, A., Torelli, E., Garcea, M. R., Lombardi, V., Lecconi, L., Valeri, L., Presenti, L., Alessio, F., Ventrucci, M., Virzi, S., Cipolla, A., De Rai, P, Zerbi, A, Castoldi, L, Bassi, C, Frulloni, L, Uomo, G, Gabbrielli, A, Pezzilli, R, Cavallini, G, Di Carlo, V, Proinf, Aisp, and Testoni, PIER ALBERTO
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Male ,Time Factors ,Pancreatitis, Alcoholic ,medicine.medical_treatment ,Acute pancreatitis ,Surgery ,Aged ,Biliary Tract Diseases ,Chi-Square Distribution ,Cholangiopancreatography, Endoscopic Retrograde ,Cholecystectomy, Laparoscopic ,Female ,Guideline Adherence ,Humans ,Italy ,Pancreatitis ,Pancreatitis, Acute Necrotizing ,Practice Guidelines as Topic ,Prospective Studies ,Risk Assessment ,Risk Factors ,Severity of Illness Index ,Treatment Outcome ,Cholecystectomy ,Jejunostomy ,Pancreatectomy ,Practice Patterns, Physicians' ,Hepatology ,Gastroenterology ,Physician's Practice Patterns ,Practice Patterns ,surgery ,Endoscopic Retrograde ,Medicine ,Cholangiopancreatography ,Laparoscopic ,Acute Necrotizing ,Alcoholic ,Prospective cohort study ,health care economics and organizations ,acute pancreatitis ,Corrigendum ,Risk assessment ,medicine.medical_specialty ,education ,Severity of illness ,Intensive care medicine ,Physicians' ,business.industry ,General surgery ,Original Articles ,medicine.disease ,business - Abstract
OBJECTIVE: This study aimed to evaluate the surgical treatment of acute pancreatitis in Italy and to assess compliance with international guidelines. METHODS: A series of 1173 patients in 56 hospitals were prospectively enrolled and their data analysed. RESULTS: Twenty-nine patients with severe pancreatitis underwent surgical intervention. Necrosectomy was performed in 26 patients, associated with postoperative lavage in 70% of cases. A feeding jejunostomy was added in 37% of cases. Mortality was 21%. Of the patients with mild pancreatitis, 714 patients with a biliary aetiology were evaluated. Prophylactic treatment of relapses was carried out in 212 patients (36%) by cholecystectomy and in 161 using a laparoscopic approach. Preoperative endoscopic retrograde cholangiopancreatography was associated with cholecystectomy in 83 patients (39%). Forty-seven patients (22%) were treated at a second admission, with a median delay of 31 days from the onset of pancreatitis. Eighteen patients with severe pancreatitis underwent cholecystectomy 37.9 days after the first admission. There were no deaths. DISCUSSION: The results indicate poor compliance with published guidelines. In severe pancreatitis, early surgical intervention is frequently performed and enteral feeding is seldom used. Only a small number of patients with mild biliary pancreatitis undergo definitive treatment (i.e. cholecystectomy) within 4 weeks of the onset of pancreatitis.
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- 2010
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23. OC.05.3: Endoscopic Ultrasound-Guided Tissue Sampling with a New 20G Biopsy Needle for the Characterization of Gastrointestinal Subepithelial Lesions: Results of a Preliminary Multicenter Study
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Antonini, F., primary, Delconte, G., additional, Fuccio, L., additional, De Nucci, G., additional, Fabbri, C., additional, Armellini, E., additional, Frazzoni, L., additional, Fornelli, A., additional, Mandelli, E., additional, Magarotto, A., additional, Occhipinti, P., additional, Masci, E., additional, Manes, G., additional, and Macarri, G., additional
- Published
- 2017
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24. P.06.25: EUS-Guided 25 GAUGE-Needle Core Biopsy as a Salvage Strategy for the Diagnosis of Small Subepithelial Tumors of the Upper Gastrointestinal Tract
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Antonini, F., primary, Fuccio, L., additional, Angelelli, L., additional, Belfiori, V., additional, De Minicis, S., additional, Lo Cascio, M., additional, Marraccini, B., additional, Piergallini, S., additional, Rossetti, P., additional, Traini, S., additional, Calcina, S., additional, Andrenacci, E., additional, and Macarri, G., additional
- Published
- 2017
- Full Text
- View/download PDF
25. Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation-predominant irritable bowel syndrome and functional constipation
- Author
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Neri, L., Iovino, P., Altomare, D. F., Annese, V., Badiali, D., Basilisco, G., Bassotti, G., Battaglia, E., Bazzocchi, G., Bellini, M., Bendia, E., Benini, L., Biscaglia, G., Biviano, I., Bocchini, R., Bonventre, S., Bossa, F., Brandimarte, G., Cannizzaro, R., Cicala, M., Cipolletta, L., Clara, V., Cogliandro, R., Comandini, G., Corazziari, E., Crotta, S., Cuomo, R., D'Alba, L., De Giorgi, F., Del Piano, M., Di Fonzo, M., Di Mario, F., Di Stefano, M., D'Onofrio, V., Efthymakis, K., Fiore, P., Fortuna, M., Fries, W., Gaetani, Eleonora, Galeazzi, F., Gasbarrini, Antonio, Geccherle, A., Giangregorio, F., Girardi, L., Grassini, M., Groppo, M., Guarnieri, G., Lo Cascio, M., Lolli, R., Luzza, F., Macarri, G., Marino, M., Miraglia, S., Monastra, S., Neri, M. C., Neri, M., Noris, R. A., Orselli, S., Passaretti, S., Paviotti, A., Pazzi, P., Pilotto, A., Portincasa, P., Ranaldo, N., Ravelli, P., Rogai, F., Sablich, R., Savarino, V., Spinzi, G., Stanghellini, V., Tammaro, L., Torresan, F., Usai Satta, P., Valle C., Claudio, Gaetani E. (ORCID:0000-0002-7808-1491), Gasbarrini A. (ORCID:0000-0002-7278-4823), Neri, L., Iovino, P., Altomare, D. F., Annese, V., Badiali, D., Basilisco, G., Bassotti, G., Battaglia, E., Bazzocchi, G., Bellini, M., Bendia, E., Benini, L., Biscaglia, G., Biviano, I., Bocchini, R., Bonventre, S., Bossa, F., Brandimarte, G., Cannizzaro, R., Cicala, M., Cipolletta, L., Clara, V., Cogliandro, R., Comandini, G., Corazziari, E., Crotta, S., Cuomo, R., D'Alba, L., De Giorgi, F., Del Piano, M., Di Fonzo, M., Di Mario, F., Di Stefano, M., D'Onofrio, V., Efthymakis, K., Fiore, P., Fortuna, M., Fries, W., Gaetani, Eleonora, Galeazzi, F., Gasbarrini, Antonio, Geccherle, A., Giangregorio, F., Girardi, L., Grassini, M., Groppo, M., Guarnieri, G., Lo Cascio, M., Lolli, R., Luzza, F., Macarri, G., Marino, M., Miraglia, S., Monastra, S., Neri, M. C., Neri, M., Noris, R. A., Orselli, S., Passaretti, S., Paviotti, A., Pazzi, P., Pilotto, A., Portincasa, P., Ranaldo, N., Ravelli, P., Rogai, F., Sablich, R., Savarino, V., Spinzi, G., Stanghellini, V., Tammaro, L., Torresan, F., Usai Satta, P., Valle C., Claudio, Gaetani E. (ORCID:0000-0002-7808-1491), and Gasbarrini A. (ORCID:0000-0002-7278-4823)
- Abstract
Background: The management of bloating is unclear and its relationship with patients' well-being and treatment satisfaction independent of other abdominal symptoms is uncharacterized. We evaluated the association of bloating with patient-reported outcomes. Methods: Thirty-nine centers for functional gastrointestinal disorders joined the laxative inadequate relief survey. We enrolled 2203 consecutive outpatients with functional constipation (FC) or constipation-predominant irritable bowel syndrome (IBS-C) in two cross-sectional waves. Both wave 1 and 2 included the SF-12, the patient assessment of constipation-symptoms (PAC-SYM), and the treatment satisfaction questionnaire for medication (TSQM-2). Wave 2 only included a global rating of change (GRC) scale to assess patients' assessment of efficacy concerning treatment switches occurred in the 3 months prior to the interview. Bloating in the abdomen was defined on the basis of PAC-SYM item 3. Key Results: The average age was 50.1 years (SD, 16.7) and 82.1% of patients were women. The prevalence of bloating was 91.6% (n = 1970). Bloating was associated with SF-12 Physical Composite Score (p < 0.01), SF-12 Mental Composite Score (p < 0.01), GRC (p < 0.01), Satisfaction with treatment effectiveness (p < 0.01), convenience of administration (p < 0.01), and side effects (p < 0.01) after adjustment for possible confounders. Conclusions & Inferences: Our data suggest that patients regard bloating as a key element in assessing clinical changes and treatments' efficacy as this symptom exerts a strong influence on patient-reported outcomes independent of possible confounders and other symptoms of constipation. Our data provide the rationale to investigate the efficacy and tolerability of new treatments specifically addressing this important, yet disregarded, patients' complain.
- Published
- 2016
26. RISK FACTORS FOR POST-ERCP IN HIGH- AND LOW-VOLUME CENTERS AND AMONG EXPERT AND NON-EXPERT OPERATORS: A PRIOSPECTIVE MULTICENTER STUDY
- Author
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TESTONI , PIER ALBERTO, MARIANI A, GIUSSANI A, VAILATI C, MASCI E, MACARRI G, GHEZZO L, FAMILIARI L, GIARDULLO N, MUTIGNANI M, LOMBARDI G, TALAMINI G, SPADACCINI A, BRIGLIA R, PIAZZI L., Testoni, PIER ALBERTO, Mariani, A, Giussani, A, Vailati, C, Masci, E, Macarri, G, Ghezzo, L, Familiari, L, Giardullo, N, Mutignani, M, Lombardi, G, Talamini, G, Spadaccini, A, Briglia, R, and Piazzi, L.
- Abstract
OBJECTIVES: Prospective studies have identified a number of patient- and procedure-related independent risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, with different conclusions, so various questions are still open. The endoscopist's expertise, case volume, and case mix can all significantly influence the outcome of ERCP procedures, but have been investigated little to date. METHODS: We identified patient- and procedure-related risk factors for post-ERCP pancreatitis and the impact of the endoscopist's experience and the center's case volume, using univariate and multivariate analysis, in a multicenter, prospective study involving low- and high-volume centers, over a 6-month period. RESULTS: A total of 3,635 ERCP procedures were included; 2,838 (78%) ERCPs were performed in the 11 high-volume centers (median 257 each) and 797 in the 10 low-volume centers (median 45 each). Overall, 3,331 ERCPs were carried out by expert operators and 304 by less-skilled operators. There were significantly more grade 3 difficulty procedures in high-volume centers than in low-volume ones (P10 attempts to cannulate the Vater's papilla, pancreatic duct cannulation, contrast injection of the pancreatic ductal system, pre-cut technique, and pancreatic sphincterotomy, among procedure-related risk factors. Multivariate analysis also showed that a history of post-ERCP pancreatitis, biliary pain, >10 attempts to cannulate the Vater's papilla, main pancreatic duct cannulation, and pre-cut technique were significantly associated with the complication. CONCLUSIONS: A history of pancreatitis among patient-related factors, and multiple attempts at cannulation among procedure-related factors, were associated with the highest rates of post-ERCP pancreatitis. Pre-cut sphincterotomy, although identified as another significant risk factor, appeared safer when done early (fewer than 10 attempts at cannulating), compared with repeated multiple cannulation. The risk of post-ERCP pancreatitis was not associated with the case volume of either the single endoscopist or the center; however, high-volume centers treated a larger proportion of patients at high risk of pancreatitis and did a significantly greater number of difficult procedures
- Published
- 2010
27. V.01.7 ENDOSCOPIC ULTRASOUND-GUIDED SINGLE-INCISION WITH NEEDLE KNIFE AND DEEP TISSUE BIOPSY FOR THE DIAGNOSIS OF A GASTRIC SUBEPITHELIAL TUMOR
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Antonini, F., primary, Belfiori, V., additional, Santinelli, A., additional, De Minicis, S., additional, Lo Cascio, M., additional, Marraccini, B., additional, Piergallini, S., additional, Rossetti, P., additional, Andrenacci, E., additional, and Macarri, G., additional
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- 2016
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28. P.03.9 IS ENDOSCOPIC ULTRASONOGRAPHY USEFUL IN SUBJECTS HAVING ASYMPTOMATIC CHRONIC PANCREATIC HYPERENZYMEMIA?
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Antonini, F., primary, Valerio, B., additional, Pagano, N., additional, De Minicis, S., additional, Lo Cascio, M., additional, Marraccini, B., additional, Piergallini, S., additional, Rossetti, P., additional, Andrenacci, E., additional, Macarri, G., additional, and Pezzilli, R., additional
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- 2016
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29. OC.08.7 BILIARY STENT DOES NOT INFLUENCE THE ADEQUACY AND ACCURACY OF EUS-GUIDED TISSUE ACQUISITION WITH FENESTRATED NEEDLES OF PANCREATIC MASSES CAUSING OBSTRUCTIVE JAUNDICE
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Antonini, F., primary, Fuccio, L., additional, Fabbri, C., additional, Frazzoni, L., additional, Belfiori, V., additional, De Minicis, S., additional, Lo Cascio, M., additional, Marraccini, B., additional, Piergallini, S., additional, Andrenacci, E., additional, and Macarri, G., additional
- Published
- 2016
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30. P.18.10 SAFETY AND EFFICACY OF UNDILUITED N-BUTYL-2 CYANOACRYLATE INJECTION AS ENDOSCOPIC RESCUE THERAPY FOR REFRACTORY ACUTE NONVARICEAL UPPER GASTROINTESTINAL BLEEDING
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Antonini, F., primary, Rossetti, P., additional, Manta, R., additional, Piergallini, S., additional, Sica, M., additional, Belfiori, V., additional, De Minicis, S., additional, Lo Cascio, M., additional, Marraccini, B., additional, Andrenacci, E., additional, Mutignani, M., additional, and Macarri, G., additional
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- 2016
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31. V.01.13 ENDOSCOPIC LIGATION AND RESECTION OF A LARGE SYMPTOMATIC SUBEPITHELIAL TUMOR OF THE DUODENUM
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Antonini, F., primary, Belfiori, V., additional, De Minicis, S., additional, Lo Cascio, M., additional, Marraccini, B., additional, Piergallini, S., additional, Rossetti, P., additional, Andrenacci, E., additional, and Macarri, G., additional
- Published
- 2016
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32. V.02.13 METASTATIC MELANOMA OF THE GALLBLADDER DIAGNOSED BY ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE BIOPSY
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Antonini, F., primary, Acito, L., additional, Sisti, S., additional, Angelelli, L., additional, Belfiori, V., additional, De Minicis, S., additional, Lo Cascio, M., additional, Marraccini, B., additional, Piergallini, S., additional, Rossetti, P., additional, Andrenacci, E., additional, and Macarri, G., additional
- Published
- 2016
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33. Hepatic stellate cell activation and liver fibrosis are associated with necroinflammatory injury and Th1-like response in chronic hepatitis C
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Baroni GS, Pastorelli A, Manzin A, Benedetti A, Marucci L, Solfarosi L, Di Sario A, Brunelli E, Orlandi F, Macarri G., CLEMENTI , MASSIMO, Baroni, G, Pastorelli, A, Manzin, A, Benedetti, A, Marucci, L, Solfarosi, L, Di Sario, A, Brunelli, E, Orlandi, F, Clementi, Massimo, and Macarri, G.
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- 1999
34. Surgical management of acute pancreatitis in Italy: lessons from a prospective multicentre study
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DE RAI, P, Zerbi, A, Castoldi, L, Bassi, C, Frulloni, L, Uomo, G, Gabbrielli, A, Pezzilli, R, Cavallini, G, DI CARLO, V, PROINF AISP PROGETTO INFORMATIZZATO PANCREATITE ACUTA, ASSOCIAZIONE ITALIANA PER LO STUDIO DEL PANCREAS COMPUTERIZED PROJECT ON ACUTE PANCREATITIS, COLLABORATORS AGUGIARO S, ITALIAN ASSOCIATION FOR THE STUDY OF THE PANCREAS STUDY G. R. O. U. P., Turri, L, Bartoli, A, Barberini, F, Cavazzoni, G, Bartolo, F, Papa, Dd, Bassi, Nicolo', Massani, M, Benedetti, A, Macarri, G, Piergallini, L, Briani, G, Bartolasi, L, Bugnano, L, Buonanno, Gm, Esposito, C, Cordovana, A, Cavina, E, Seccia, M, Lippolis, P, Musco, B, Barletta, M, Chilovi, E, DE GUELFI, A, Chirletti, P, Caronna, R, Scozzafava, S, Cardi, M, Cirino, E, Buffone, A, Colangelo, E, Caracino, V, Cortese, F, Casentini, A, Costamagna, G, Trincali, A, Curzio, M, Clivio, S, Segato, S, D'Alessandro, A, Ambrosiani, V, D'Ambrosio, B, Chiodo, C, Dicillo, M, Reale, L, Grandolfo, A, Fabbrucci, P, Bruscino, A, Mugnaini, P, Ferrarese, S, Ugenti, I, Forte, Gb, Rocco, P, Franzãˆ, A, Bertelãˆ, A, Sereni, G, Friedman, D, Mariani, L, Morelli, F, Gai, V, Antro, C, Garcea, D, Gardini, A, Lucci, E, Giulianotti, Pc, Sbrana, F, Balestracci, T, Giulini, Sm, Pellizzari, A, Ronconi, M, Cimaschi, S, Grassini, M, Lacignola, S, Calandro, L, Mazzitelli, L, Costarella, Sm, Egidio, A, Teggia, Pm, Stefano, E, Cassini, P, Modica, G, Lupo, F, Giraci, G, Mosca, F, DEL CHIARO, M, Mosella, G, Benassai, G, Nanni, M, D'Aristotile, A, Negro, P, Pirazzoli, A, Rabitti, Pg, Romano, C, Gerardi, G, Troianello, B, Russello, D, DI STEFANO, A, Avelli, S, Salval, N, Bellini, N, Scalon, P, Staudacher, C, Parolini, D, Strazzabosco, M, Signorelli, S, Tedeschi, U, Testoni, Pa, Masci, E, Mariani, A, Torelli, E, Garcea, Mr, Lombardi, V, Lecconi, L, Valeri, L, Presenti, L, Alessio, F, Ventrucci, M, Virzi, S, and Cipolla, A.
- Published
- 2010
35. Risk factor post-ERCP pancreatitis in high- and low-volume centers and among expert and non-expert operators. A prospective multicentre study
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Testoni, Pa, Mariani, A, Giussani, A, Vailati, C, Masci, E, Macarri, G, Ghezzo, L, Familiari, L, Giardullo, N, Mutignani, M, Lombardi, G, Talamini, Giorgio, Spadaccini, A, Briglia, R, and Piazzi, L.
- Subjects
post-ERCP pancreatitis ,Endoscopic retrograde pancreatography ,pancreatitis - Published
- 2010
36. Risk factors for post-ERCP pancreatitis in high- and low-volume centers and among expert and non-expert operators: a prospective multicenter study
- Author
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Testoni, Pa, Mariani, A, Giussani, A, Vailati, C, Masci, E, Macarri, G, Ghezzo, L, Familiari, L, Giardullo, N, Mutignani, M, Lombardi, G, Talamini, G, Spadaccini, A, Briglia, R, Piazzi, L, Gabbrielli, A, Casadei, A, Terruzzi, V, Golia, M, Tampieri, I, Borruto, A, Tombesi, G, and Polese, Lino
- Subjects
Adult ,Male ,medicine.medical_specialty ,Iohexol ,MEDLINE ,pancreatitis ,Contrast Media ,medicine ,Humans ,risk factors ,Prospective Studies ,Risk factor ,Prospective cohort study ,Diagnosis-Related Groups ,Aged ,Cholangiopancreatography, Endoscopic Retrograde ,Chi-Square Distribution ,ercp ,Hepatology ,business.industry ,General surgery ,ERCP ,Pancreatitis ,Gastroenterology ,Middle Aged ,medicine.disease ,digestive system diseases ,Low volume ,surgical procedures, operative ,Logistic Models ,Multicenter study ,Italy ,Emergency medicine ,Female ,Clinical Competence ,Post ercp pancreatitis ,business ,Chi-squared distribution - Abstract
Prospective studies have identified a number of patient- and procedure-related independent risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, with different conclusions, so various questions are still open. The endoscopist's expertise, case volume, and case mix can all significantly influence the outcome of ERCP procedures, but have been investigated little to date.We identified patient- and procedure-related risk factors for post-ERCP pancreatitis and the impact of the endoscopist's experience and the center's case volume, using univariate and multivariate analysis, in a multicenter, prospective study involving low- and high-volume centers, over a 6-month period.A total of 3,635 ERCP procedures were included; 2,838 (78%) ERCPs were performed in the 11 high-volume centers (median 257 each) and 797 in the 10 low-volume centers (median 45 each). Overall, 3,331 ERCPs were carried out by expert operators and 304 by less-skilled operators. There were significantly more grade 3 difficulty procedures in high-volume centers than in low-volume ones (P0.0001). Post-ERCP pancreatitis occurred in 137 patients (3.8%); the rates did not differ between high- and low-volume centers (3.9% vs. 3.1%) and expert and non-expert operators (3.8% vs. 5.5%). However, in high-volume centers, there were 25% more patients with patient- and procedure-related risk factors, and the pancreatitis rate was one-third higher among non-expert operators. Univariate analysis found a significant association with pancreatitis for history of acute pancreatitis, either non-ERCP- or ERCP-related and recurrent, young age, absence of bile duct stones, and biliary pain among patient-related risk factors, and10 attempts to cannulate the Vater's papilla, pancreatic duct cannulation, contrast injection of the pancreatic ductal system, pre-cut technique, and pancreatic sphincterotomy, among procedure-related risk factors. Multivariate analysis also showed that a history of post-ERCP pancreatitis, biliary pain,10 attempts to cannulate the Vater's papilla, main pancreatic duct cannulation, and pre-cut technique were significantly associated with the complication.A history of pancreatitis among patient-related factors, and multiple attempts at cannulation among procedure-related factors, were associated with the highest rates of post-ERCP pancreatitis. Pre-cut sphincterotomy, although identified as another significant risk factor, appeared safer when done early (fewer than 10 attempts at cannulating), compared with repeated multiple cannulation. The risk of post-ERCP pancreatitis was not associated with the case volume of either the single endoscopist or the center; however, high-volume centers treated a larger proportion of patients at high risk of pancreatitis and did a significantly greater number of difficult procedures.
- Published
- 2010
37. Evolution of the Hypervariable Region 1 (HVR-1) of Hepatitis C Virus in Primary Infection
- Author
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MANZIN A., SOLFOROSI L., PETRELLI E., MACARRI G., TOSONE G., PIAZZA M., CLEMENTI , MASSIMO, Manzin, A., Solforosi, L., Petrelli, E., Macarri, G., Tosone, G., Piazza, M., and Clementi, Massimo
- Published
- 1998
38. Diagnostic assessment and outcome of acute pancreatitis in Italy: results of a prospective multicentre study. ProInf-AISP: Progetto informatizzato pancreatite acuta, Associazione Italiana Studio Pancreas, phase II
- Author
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Uomo, G, Pezzilli, R., Gabbrielli, A., Castoldi, L., Zerbi, A., Frulloni, L., De Rai, P., Cavallini, G., Di Carlo, V., Agugiaro, S., Turri, L., Bartoli, A., Barberini, F., Cavazoni, G., Bartolo, F., Della Papa, D., Bassi, C., Bassi, N., Massani, M., Benedetti, A., Macarri, G., Piergallini, L., Briani, G., Bartolasi, L., Brugnano, L., Buonanno, G. M., Esposito, C., Cardovana, A., Cavina, E., Seccia, M., Lipollis, P., Musco, B., Barletta, M., Chilovi, E., De Guelmi, A., Chirletti, P., Caronna, R., Scozzafava, S., Cardi, M., Cirrino, E., Buffone, A., Colangelo, E., Caracino, V., Cortese, F., Cosentini, A., Costamagna, G., Tringali, A., Curzio, M., Clivio, S., Segato, S., D'Alessandro, A., Ambrosini, V., D'Amborsio, B., Chiodo, C., Dicillo, M., Reale, L., Grandolfo, A., Fabbrucci, P., Bruscino, A., Mugnaini, P., Ferrarese, S., Ugenti, I., Forte, G. B., Rocco, P., Franzè, A., Bertelè, A., Sereni, G., Friedman, Daniele, Mariani, L. M., Murelli, Federica, Gai, V., Antro, C., Garcea, D., Gardini, A., Lucci, E., Giulianotti, P. C., Sbrana, F., Balestracci, T., Giulini, S. M., Pellizzari, A., Ronconi, M., Cimaschi, S., Grassini, M., Lacitignola, S., Caliandro, L., Mazzitelli, R., Costarella, S. M., Egidio, A., Mello Teggia, P., Stefano, E., Cassini, P., Modica, G., Lupo, F., Giraci, G., Mosca, F., Del Chiaro, M., Mosella, G., Benassai, G., Nanni, M., D'Aristotile, A., Negro, P., Pirazzoli, A., Rabitti, P. G., Romano, C., Gerardi, G., Troianello, B., Russello, D., Di Stefano, A., Avelli, S., Salvai, M., Bellini, N., Scalon, P., Staudacher, C., Parolini, D., Strazzabosco, M., Signorelli, S., Tedeschi, U., Testoni, P. A., Masci, E., Mariani, A., Torelli, E., Garcea, M. R., Lombardi, V., Cecconi, L., Valeri, A., Presenti, L., Alessio, F., Ventrucci, M., Virzì, S., and Cipolla, A.
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Adult ,Male ,Pancreatic necrosis ,Severity of Illness Index ,Body Mass Index ,Acute Pancreatitis ,Clinical outcome ,Computed tomography ,Diagnosis ,Pancreatitis ,Prognosis ,Ultrasonography ,Aged ,Aged, 80 and over ,Cholangiopancreatography, Endoscopic Retrograde ,Creatinine ,Female ,Humans ,Italy ,Middle Aged ,Prospective Studies ,Treatment Outcome ,Hepatology ,Gastroenterology ,Endoscopic Retrograde ,80 and over ,treatment ,Medicine (all) ,Cholangiopancreatography ,acute pancreatitis ,diagnosis - Abstract
Up till now, only one study providing practically complete information on acute pancreatitis in Italy has been published. The aim of this prospective study was to evaluate the clinical characteristics, in terms of diagnostic assessment and outcome, of a large series of patients affected by acute pancreatitis in Italy.The study involved 56 Italian centres, homogeneously distributed throughout the entire national territory. Each participating centre was furnished with an ad hoc software including 530 items along with subsequent collection, tabulation and quality control of the data.One thousand five hundred and forty case report forms of patients affected by acute pancreatitis were collected but 367 of them (24%) were subsequently eliminated from the final analysis. Therefore, 1173 patients (581 females and 592 males) were recruited. Mean age of patients was 62.0+/-18.2 years (95% confidence interval, 60.9-63.0). On the basis of Atlanta classification, 1006 patients (85.8%) were defined as mild and 167 (14.2%) as severe pancreatitis. Biliary forms represented the most frequent aetiological category (813 cases, 69.3%) while alcoholic forms only 6.6% (77 cases); the remaining aetiologies accounted for 7.1% (83 cases) while 200 cases (17.1%) remained without a definite aetiological factor. Complete recovery was achieved in 1016 patients (86.6%) whereas morphological sequelae were found in 121 patients (10.3%) and mortality in 36 patients (3.1%; 0.4% in mild and 19.2% in severe acute pancreatitis). Ultrasonography was largely utilised as a first line diagnostic tool in all patients, with valuable visualisation of the pancreas in 85% of patients. Computer tomography scan was also widely used, with 66.7% of exams in mild and 33.3% in severe pancreatitis. Patients affected by biliary pancreatitis presented more severe (p=0.004) and necrotizing forms (p=0.021). Mortality was significantly related (p0.001) with the extension of pancreatic necrosis and with an age of over 70 years. Body mass index presented significantly greater values in severe than in mild forms (p0.001).Association of creatinine serum level over 2mg/dl with an abnormal chest X-ray showed a high significant correlation with a more severe outcome in terms of morphological sequelae and mortality (p=0.0001). Acute pancreatitis in Italy more commonly presents biliary aetiology and favourable outcome with low rate of complications and mortality. From a cost-effectiveness standpoint, diagnostic approach to this disease needs to be better standardised.
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- 2007
39. A prospective multicentre survey on the treatment of acute pancreatitis in Italy
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Pezzilli, R, Uomo, G., Gabbrielli, A., Zerbi, A., Frulloni, L., De Rai, P., Castoldi, L., Cavallini, G., Di Carlo, V., Agugiaro, S., Turri, L., Bartoli, A., Barberini, F., Cavazoni, G., Bartolo, F., Della Papa, D., Bassi, C., Bassi, N., Massani, M., Benedetti, A., Macarri, G., Piergallini, L., Briani, G., Bartolasi, L., Brugnano, L., Buonanno, G. M., Esposito, C., Cardovana, A., Cavina, E., Seccia, M., Lipollis, P., Musco, B., Barletta, M., Chilovi, E., De Guelmi, A., Chirletti, Piero, Caronna, Roberto, Scozzafava, S., Cardi, Maurizio, Cirino, E., Buffone, A., Colangelo, E., Caracino, V., Cortese, F., Cosentini, A., Costamagna, G., Tringali, A., Curzio, M., Clivio, S., Segato, S., D'Alessandro, A., Ambrosini, V., D'Amborsio, B., Chiodo, C., Dicillo, M., Reale, L., Grandolfo, A., Fabbrucci, P., Bruscino, A., Mugnaini, P., Ferrarese, S., Ugenti, I., Forte, G. B., Rocco, P., Franzè, A., Bertelè, A., Sereni, G., Friedman, D., Mariani, L. M., Murelli, F., Gai, V., Antro, C., Garcea, D., Gardini, A., Lucci, E., Giulianotti, P. C., Sbrana, F., Balestracci, T., Giulini, S. M., Pellizzari, A., Ronconi, M., Cimaschi, S., Grassini, M., Lacitignola, S., Caliandro, L., Mazzitelli, R., Costarella, S. M., Egidio, A., Mello Teggia, P., Stefano, E., Cassini, P., Modica, G., Lupo, F., Giraci, G., Mosca, F., Del Chiaro, M., Mosella, G., Benassai, G., Nanni, M., D'Aristotile, A., Negro, P., Pirazzoli, A., Rabitti, P. G., Romano, C., Gerardi, G., Troianello, B., Russello, D., Di Stefano, A., Avelli, S., Salvai, M., Bellini, N., Scalon, P., Staudacher, C., Parolini, D., Strazzabosco, M., Signorelli, S., Tedeschi, U., Testoni, P. A., Masci, E., Mariani, A., Torelli, E., Garcea, M. R., Lombardi, V., Cecconi, L., Valeri, A., Presenti, L., Alessio, F., Ventrucci, M., Virzi, S., and Cipolla, A.
- Subjects
Adult ,Male ,medicine.medical_specialty ,ERCP ,Pancreatitis ,Pancreatitis acute necrotising ,Aged ,Aged, 80 and over ,Analgesics ,Anti-Bacterial Agents ,Digestive System Surgical Procedures ,Female ,Histamine Antagonists ,Humans ,Italy ,Middle Aged ,Prospective Studies ,Severity of Illness Index ,Treatment Outcome ,Medicine (all) ,Hepatology ,Gastroenterology ,Therapeutic approach ,Internal medicine ,Severity of illness ,80 and over ,Medicine ,Prospective cohort study ,business.industry ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Acute pancreatitis ,Tramadol ,business ,Pancreas ,medicine.drug - Abstract
The Italian Association for the Study of the Pancreas released a diagnostic and therapeutic algorithm for acute pancreatitis in 1999.This study focused on the analysis of the therapeutic approach for the treatment of acute pancreatitis in Italy.One thousand, one hundred and seventy-three patients were recruited: 1006 patients (85.8%) had mild acute pancreatitis (MAP) and 167 (14.2%) had the severe acute pancreatitis (SAP); 161 patients showed pancreatic necrosis at computed tomography; 121 patients (10.3%) had sequelae and 36 (3.1%) died.Non-steroidal anti-inflammatory drugs and tramadol were used more frequently in patients with the MAP whereas opioids and the association schedules were used more frequently in patients with the SAP (P0.001). Gabexate mesilate was utilised in 831 out of 1173 patients (70.8%); in particular, gabexate mesilate was used in 70.6% patients with MAP and in 73.1% of those with SAP (P=0.521). The duration of the drug administration was significantly shorter in those having MAP than in those having the SAP (P0.001). The antibiotics most frequently used for the prophylaxis against infection from pancreatic necrosis (43.1%) were carbapenems. Only a small number of patients received enteral nutrition (4.7%). Endoscopic retrograde cholangiopancreatography was carried out in 344 of the 1173 patients (29.3%). Surgery was performed in 48 with SAP (19 had elective biliary surgery and 29 had pancreatic surgery).The results of this survey indicate a lack of compliance with the guidelines which regard the indications mainly for interventional endoscopy and surgery.
- Published
- 2007
40. Biliary insulin like growth factor-1 (IGF1) is a sensitive marker for the diagnosis of extrahepatic cholangiocarcinoma
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Alvaro, Domenico, Macarri, G., Mancino, M., Marzioni, M., Bragazzi, MARIA CONSIGLIA, Onori, Paolo, GINANNI CORRADINI, Stefano, Invernizzi, P., Franchitto, Antonio, Gaudio, Eugenio, and Benedetti, A.
- Published
- 2007
41. A Hitherto Undescribed Component of the Perisinusoidal Space in Normal Human Liver: the Mast Cell1
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Jezequel, A. M., primary, Macarri, G., additional, Brunelli, E., additional, and Orlandi, F., additional
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42. A simplified clinical risk score predicts the need for early endoscopy in non-variceal upper gastrointestinal bleeding
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Tammaro, Leonardo, primary, Buda, Andrea, additional, Di Paolo, Maria Carla, additional, Zullo, Angelo, additional, Hassan, Cesare, additional, Riccio, Elisabetta, additional, Vassallo, Roberto, additional, Caserta, Luigi, additional, Anderloni, Andrea, additional, Natali, Alessandro, additional, Pallotta, L., additional, Vitale, M.A., additional, Parodi, M.C., additional, Balzano, A., additional, Sturniolo, G.C., additional, Lamboglia, F., additional, D’Angelo, A., additional, Testai, F.V., additional, Frosini, G., additional, Marini, M., additional, D’Amico, G., additional, Montalbano, L.M., additional, Sinagra, E., additional, Macarri, G., additional, Antonini, F., additional, Occhigrossi, G., additional, Caliendo, S., additional, Campaioli, M., additional, Peccianti, C., additional, Spotti, D., additional, Colucci, A., additional, Marin, R., additional, Cervellin, E., additional, Conio, M., additional, De Matthaeis, M., additional, Biagini, M., additional, Scarpulla, G., additional, Camilleri, S., additional, Lauri, A., additional, De Fanis, C., additional, Craxì, A., additional, Peralta, S., additional, Kohn, A., additional, Tesi, A., additional, Azzurro, M., additional, Ferronato, A., additional, Conigliaro, R., additional, Manno, M., additional, Manta, R., additional, Adamo, S., additional, Brunelli, E., additional, Ridolfi, F., additional, De Boni, M., additional, De Bona, M., additional, Guglielmi, F.W., additional, Mazzuoli, S., additional, Occhipinti, P., additional, Ventrucci, M., additional, Pozzato, P., additional, Milani, S., additional, Virgilio, C., additional, Costa, G., additional, and Di Bella, S., additional
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- 2014
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43. COMPARISON OF TWO DOSING REGIMENS OF GABEXATE IN THE PROPHYLAXIS OF POST-ERCP PANCREATITIS
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Masci, E, Cavallini, G, Mariani, A, Frulloni, L, Testoni, Pa, Curioni, S, Tittobello, A, Uomo, G, Costamagna, G, Zambelli, S, Macarri, G, Innocenti, P, Dragonetti, C, Angelini, Gp, Bonardi, L, Ayoubi, M, Caputi, O, Casetti, T, Tampieri, I, Cestari, R, Salerni, B, DE GRAZIA, F, DE PRETIS, G, Zilli, M, Zoratti, L, DEL PIANO, M, Occhipinti, P, D'Imperio, N, Billi, P, Pezzilli, R, Casadei, A, Familiari, Luigi, Benedetti, A, Giardini, M, Forte, Gb, Rocco, P, Leo, P, Ficano, L, Sciume', C, Loriga, P, Bergamini, S, Muscas, A, Mosca, S, Nicosia, F, Caldini, F, Norberto, L, D'Amico, D, Perri, V, Gabrielli, A, Pugliese, V, Russo, A, Bonanno, G, Viceconte, G, and Piglionica, D.
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- 2003
44. Long term outcome of acute pancreatitis in Italy: Results of a multicentre study
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Castoldi, L, De Rai, P, Zerbi, A, Frulloni, L, Uomo, G, Gabbrielli, A, Bassi, C, Pezzilli, R, Agugiaro, S, Turri, L, Bartoli, A, Barberini, F, Cavazzoni, G, Bartolo, F, Papa, D, Bassi, N, Massani, M, Benedetti, A, Macarri, G, Piergallini, L, Briani, G, Bartolasi, L, Bugnano, L, Buonanno, G, Esposito, C, Cordovana, A, Cavina, E, Seccia, M, Musco, B, Barletta, M, Chilovi, E, De Guelfi, A, Chirletti, P, Caronna, R, Scozzafava, S, Cardi, M, Cirino, E, Buffone, A, Colangelo, E, Caracino, V, Cortese, F, Casentini, A, Costamagna, G, Trincali, A, Curzio, M, Clivio, S, Segato, S, D'Alessandro, A, Ambrosiani, V, D'Ambrosio, B, Chiodo, C, Dicillo, M, Reale, L, Grandolfo, A, Fabbrucci, P, Bruscino, A, Mugnaini, P, Ferrarese, S, Ugenti, I, Forte, G, Rocco, P, Franzè, A, Bertelè, A, Sereni, G, Friedman, D, Mariani, L, Morelli, F, Gai, V, Antro, C, Garcea, D, Gardini, A, Lucci, E, Giulianotti, P, Sbrana, F, Balestracci, T, Giulini, S, Pellizzari, A, Ronconi, M, Cimaschi, S, Grassini, M, Lacignola, S, Martina, C, Mazzitelli, L, Costarella, S, Reggio, E, Mello Teggia P., N, Stefano, E, Cassini, P, Modica, G, Lupo, F, Giraci, G, Mosca, F, Del Chiaro, M, Mosella, G, Benassai, G, Nanni, M, D'Aristotile, A, Negro, P, Pirazzoli, A, Rabitti, P, Romano, C, Gerardi, G, Troianello, B, Ruscello, D, Di Stefano, A, Avelli, S, Salval, N, Bellini, N, Scalon, P, Staudacher, C, Parolini, D, Strazzabosco, M, Signorelli, S, Tedeschi, U, Testoni, P, Masci, E, Mariani, A, Torelli, E, Garcea, M, Lombardi, V, Lecconi, L, Valeri, L, Presenti, L, Alessio, F, Ventrucci, M, Virzi, S, Cipolla, A, FERRARESE, SAMUELE, Mello Teggia P. , n, Cipolla, A., STRAZZABOSCO, MARIO, Castoldi, L, De Rai, P, Zerbi, A, Frulloni, L, Uomo, G, Gabbrielli, A, Bassi, C, Pezzilli, R, Agugiaro, S, Turri, L, Bartoli, A, Barberini, F, Cavazzoni, G, Bartolo, F, Papa, D, Bassi, N, Massani, M, Benedetti, A, Macarri, G, Piergallini, L, Briani, G, Bartolasi, L, Bugnano, L, Buonanno, G, Esposito, C, Cordovana, A, Cavina, E, Seccia, M, Musco, B, Barletta, M, Chilovi, E, De Guelfi, A, Chirletti, P, Caronna, R, Scozzafava, S, Cardi, M, Cirino, E, Buffone, A, Colangelo, E, Caracino, V, Cortese, F, Casentini, A, Costamagna, G, Trincali, A, Curzio, M, Clivio, S, Segato, S, D'Alessandro, A, Ambrosiani, V, D'Ambrosio, B, Chiodo, C, Dicillo, M, Reale, L, Grandolfo, A, Fabbrucci, P, Bruscino, A, Mugnaini, P, Ferrarese, S, Ugenti, I, Forte, G, Rocco, P, Franzè, A, Bertelè, A, Sereni, G, Friedman, D, Mariani, L, Morelli, F, Gai, V, Antro, C, Garcea, D, Gardini, A, Lucci, E, Giulianotti, P, Sbrana, F, Balestracci, T, Giulini, S, Pellizzari, A, Ronconi, M, Cimaschi, S, Grassini, M, Lacignola, S, Martina, C, Mazzitelli, L, Costarella, S, Reggio, E, Mello Teggia P., N, Stefano, E, Cassini, P, Modica, G, Lupo, F, Giraci, G, Mosca, F, Del Chiaro, M, Mosella, G, Benassai, G, Nanni, M, D'Aristotile, A, Negro, P, Pirazzoli, A, Rabitti, P, Romano, C, Gerardi, G, Troianello, B, Ruscello, D, Di Stefano, A, Avelli, S, Salval, N, Bellini, N, Scalon, P, Staudacher, C, Parolini, D, Strazzabosco, M, Signorelli, S, Tedeschi, U, Testoni, P, Masci, E, Mariani, A, Torelli, E, Garcea, M, Lombardi, V, Lecconi, L, Valeri, L, Presenti, L, Alessio, F, Ventrucci, M, Virzi, S, Cipolla, A, FERRARESE, SAMUELE, Mello Teggia P. , n, Cipolla, A., and STRAZZABOSCO, MARIO
- Abstract
Background: In Italy, no long-term studies regarding the natural history of acute pancreatitis have been carried out. Aim: To report the results of a follow-up on a large series of patients hospitalised for pancreatitis. Methods: Data of 631 patients admitted to 35 Italian hospitals were retrospectively evaluated 51.7 ± 8.4 months after discharge. Results: The average recovery time after mild or severe pancreatitis was 28.2 and 53.4 days respectively. Fourteen sequelae were not resolved and 9 cases required late surgical intervention. Eighty patients (12.7%) had a second hospital admission. Of the patients with mild biliary pancreatitis, 67.9% underwent a cholecystectomy. The overall incidence of relapse was 12.7%. Mortality was 9.8% and no death was related to pancreatitis. Three patients died from carcinoma of the pancreas. Conclusion: Reported recovery time after an attack of pancreatitis was longer than expected in the mild forms. The treatment of sequelae was delayed beyond one year after discharge. The incidence of relapse of biliary pancreatitis in patients not undergoing a cholecystectomy was low, due to endoscopic treatment. Mortality from pancreatic-related causes is low, but there is an association with malignant pancreatic or ampullary tumours not diagnosed during the acute phase of the illness. © 2013 Editrice Gastroenterologica Italiana S.r.l
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- 2013
45. Observer agreement in endoscopic assessment of ulcerative colitis
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Orlandi F, Brunelli E, Feliciangeli G, Svegliati-Baroni G, Antonio Di Sario, Benedetti A, Guidarelli C, and Macarri G
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Male ,Observer Variation ,Humans ,Reproducibility of Results ,Colitis, Ulcerative ,Female ,Colonoscopy ,Sensitivity and Specificity - Abstract
Colonoscopy is the investigation of choice to evaluate ulcerative colitis, but the reliability of the assessment of endoscopic signs is not clear.The aim of this study was to evaluate interobserver agreement for the identification of endoscopic lesions typical of ulcerative colitis, and the influence of training.Four experienced observers and 11 endoscopists under training assessed 49 still images selected from endoscopic video recordings.The agreement rate between experienced observers was excellent or good (k0.39) for recognition of 10 out of 14 signs or patterns (loss of vascular pattern, erythema, oedema, granular mucosa, blood, pseudopolyp, erosion, ulcer, normal pattern, severe activity), and was poor for pus, stricture, mild activity, moderate activity. The rates between endoscopists under training were excellent or good for 6 items (loss of vascular pattern, erythema, oedema, pseudopolyp, normal pattern, severe activity).Trained observers can reproducibly record most endoscopic signs of ulcerative colitis. A reliable overall scoring of severity should be based on a simple three-grading scale, i.e. normal pattern, moderate activity, severe activity. Acceptable agreement rates can be obtained by endoscopists under training on some well-defined endoscopic appearances.
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- 1998
46. P.16.1 DIAGNOSTIC VALUE OF EUS IN THE SELECTION OF PATIENTS WITH GASTRIC CANCER ELIGIBLE FOR A NEOADJUVANT CHEMOTHERAPY
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Antonini, F., primary, Siquini, W., additional, Piergallini, S., additional, Belfiori, V., additional, Marraccini, B., additional, Lo Cascio, M., additional, Manfredi, C., additional, and Macarri, G., additional
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- 2013
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47. A survey of adverse events in 11,241 patients with chronic viral hepatitis treated with alfa interferon
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Fattovich, G., Giustina, G., Favarato, S., Ruol, A., Macarri, G., Orlandi, E., Iaquinto, G., Ambrosone, L., Francavilla, A., Pastore, G., Santantonio, M. T., Romagno, D., Bolondi, L., Sofia, S., Marchesini, A., Pisi, E., Mazzella, G., Roda, E., Attaro, L., Chiodo, E., Mori, E., Verucchi, G., Lanzini, A., Salmi, A., Calvi, B., Bozzetti, E., Radaeli, E., Bernasconi, M., Pilleri, G., Bacca, D., Romano, G., Mastrapasqua, G., Cozzolongo, R., Cacopardo, B., Nunnari, A., Blasi, A., Sala, L. O., Minoli, G., Sangiovanni, A., Spinzi, G. C., Colombo, A., Camassa, M., Riva, D., Maggi, G., Boccia, S., Gualandi, G., Nucci, A., Pacini, F., Marino, N., Mazzotta, E., La Mura, A., Pompei, A. G., Casinelli, K., Petrosillo, N., Giacchino, R., Timitilli, A., Spiga, E., Corsetti, M., Menicagli, V., Tucci, A., Bissoli, E., Raimondo, G., Rodino, G., Bellobuono, A., Ideo, G., Colombo, M., Pacchetti, S., Rumi, M. R., Battezzati, P. M., Bruno, S., Podda, M., Zuin, M., Fargion, S., Fiorelli, G., Gellmann, E., Vandelli, C., Ventura, E., Manenti, F., Villa, E., Caporaso, N., Coltorti, M., Morisco, E., Del Vecchio-Blanco, C., di Santolo, S. S., Di Nunzio, S., Ruggiero, G., Zampino, R., Ascione, A., De Luca, M., Galeota-Lanza, A., Aprea, L., Sagnelli, E., Felaco, E. M., Piccinino, E., Ballare, M., Monteverde, A., Tappero, G., Sanna, G., Alberti, A., Bonetti, P., Casarin, C., Diodati, G., Tremolada, E., Naccarato, R., Chiaramonte, M., Floreani, M. R., Almasio, P., Craxi, A., Loiacono, O., Pagliaro, L., Fiaccadori, E., Giuberti, T., Belloni, G., Bernardini, E., Buscarini, L., Sbolli, G., Giudici-Cipriani, A., Marenco, G., Mazzaro, C., Massari, M., Fornaciari, G., Plancher, A., Gasbarrini, G., Grieco, A., Luchetti, R., Rapaccini, G. L., Bombardieri, G., Di Virgilio, D., Bruno, G., Ricci, G. L., Hassan, G., Mari, T., Scalisi, I., Colloredo, G., Frunzio, A., Tabone, M., Costa, C., Rosina, E., Saracco, G., Verme, G., Frezza, M., Urban, E., Capra, E., Casaril, M., Corrocher, R., and Benetti, G. P.
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Hepatitis, Viral, Human ,Alpha interferon ,Poison control ,Chronic viral hepatitis ,Interferon alfa ,Side effects ,Gastroenterology ,Autoimmune Diseases ,Internal medicine ,Medicine ,Humans ,Adverse effect ,Child ,Aged ,Retrospective Studies ,Hepatitis ,Hepatology ,business.industry ,Thyroid disease ,Mental Disorders ,Infant, Newborn ,Infant ,Middle Aged ,medicine.disease ,Recombinant Proteins ,Surgery ,Bone marrow suppression ,Child, Preschool ,Chronic Disease ,Interferon Type I ,Female ,business ,Viral hepatitis ,medicine.drug - Abstract
Aims: The aim of this study was to assess the incidence of fatal, life-threatening side effects and the de novo appearance of non-hepatic morbidity during interferon alfa therapy for chronic viral hepatitis. The relationship of these adverse events to actual total dose and duration of interferon was also evaluated. Methods: We conducted a retrospective study at 73 Italian centers of 11 241 consecutive patients with chronic vital hepatitis who underwent interferon alfa treatment. Results: Five patients died during interferon therapy due to liver failure ( n =4) or complications arising from sepsis. Life-threatening side effects were observed in eight patients: two cases where depression developed and led to a suicide attempt and six patients with bone marrow suppression (granulocytes 3 or platelets 3 ). These symptoms and signs completely disappeared after interferon withdrawal. During interferon treatment, 131 patients developed the following de novo non-hepatic disorders: symptomatic thyroid disease ( n =71), impotence ( n =5), systemic autoimmune disease ( n =5), immune-mediated dermatologic disease ( n =14), diabetes mellitus ( n =10), cardiovascular disease ( n =7), psychosis n =10), seizures ( n =4), peripheral neuropathy ( n =3) and hemolytic anemia ( n =2). Most of these complications are reversible or can be ameliorated. Fatal or life-threatening side effects were not related to actual total dose or duration of interferon alfa, while the majority of patients with de novo non-hepatic morbidity received medium/high doses ( > 200 million units) of interferon alfa or were treated for periods longer than 16 weeks (68% and 80%, respectively). Conclusions: Treatment with interferon alfa may have fatal or life-threatening side effects, their incidence in this study being low (0.04% and 0.07%, respectively) and perhaps no different than in untreated patients with chronic viral hepatitis. Moreover de novo non-hepatic morbidity occurred in 1.2% of patients, and the dose and duration of interferon therapy seem important in determining the frequency of this complication. The development of clinically-overt thyroid disease was most common.
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- 1996
48. P.16.19 PREVALENCE AND PREDICTIVE FACTORS OF PARIETAL CELL ANTIBODY POSITIVITY IN INFLAMMATORY BOWEL DISEASE: PRELIMINARY RESULTS OF A PROSPECTIVE, CASE-CONTROL STUDY
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Antonini, F., primary, Ercoli, F., additional, Piergallini, S., additional, Belfiori, V., additional, Marraccini, B., additional, Lo Cascio, M., additional, Manfredi, C., additional, and Macarri, G., additional
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- 2012
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49. Diagnostic value of the fibrosis of the terminal hepatic venule in fatty liver and chronic hepatitis due to ethanol or other aetiology
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BRUNELLI, E., primary, MACARRI, G., additional, JEZEQULE, A. M., additional, and ORLANDI, F., additional
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- 2008
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50. Biliary insulin like growth factor-1 (IGF1) is a sensitive marker for the diagnosis of extrahepatic cholangiocarcinoma
- Author
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Mancino, M.G., primary, Macarri, G., additional, Marzioni, M., additional, Benedetti, A., additional, Bragazzi, M.C., additional, Invernizzi, P., additional, Attili, A.F., additional, and Alvaro, D., additional
- Published
- 2007
- Full Text
- View/download PDF
Catalog
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