1,505 results on '"Macaluso P"'
Search Results
2. GenSim2: Scaling Robot Data Generation with Multi-modal and Reasoning LLMs
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Hua, Pu, Liu, Minghuan, Macaluso, Annabella, Lin, Yunfeng, Zhang, Weinan, Xu, Huazhe, and Wang, Lirui
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Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Robotic simulation today remains challenging to scale up due to the human efforts required to create diverse simulation tasks and scenes. Simulation-trained policies also face scalability issues as many sim-to-real methods focus on a single task. To address these challenges, this work proposes GenSim2, a scalable framework that leverages coding LLMs with multi-modal and reasoning capabilities for complex and realistic simulation task creation, including long-horizon tasks with articulated objects. To automatically generate demonstration data for these tasks at scale, we propose planning and RL solvers that generalize within object categories. The pipeline can generate data for up to 100 articulated tasks with 200 objects and reduce the required human efforts. To utilize such data, we propose an effective multi-task language-conditioned policy architecture, dubbed proprioceptive point-cloud transformer (PPT), that learns from the generated demonstrations and exhibits strong sim-to-real zero-shot transfer. Combining the proposed pipeline and the policy architecture, we show a promising usage of GenSim2 that the generated data can be used for zero-shot transfer or co-train with real-world collected data, which enhances the policy performance by 20% compared with training exclusively on limited real data., Comment: CoRL 2024. Project website: https://gensim2.github.io/
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- 2024
3. Quantum Artificial Intelligence: A Brief Survey
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Klusch, Matthias, Lässig, Jörg, Müssig, Daniel, Macaluso, Antonio, and Wilhelm, Frank K.
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Quantum Physics ,Computer Science - Artificial Intelligence - Abstract
Quantum Artificial Intelligence (QAI) is the intersection of quantum computing and AI, a technological synergy with expected significant benefits for both. In this paper, we provide a brief overview of what has been achieved in QAI so far and point to some open questions for future research. In particular, we summarize some major key findings on the feasability and the potential of using quantum computing for solving computationally hard problems in various subfields of AI, and vice versa, the leveraging of AI methods for building and operating quantum computing devices., Comment: 21 pages, 5 figures
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- 2024
4. Quantum Annealing-Based Algorithm for Efficient Coalition Formation Among LEO Satellites
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Venkatesh, Supreeth Mysore, Macaluso, Antonio, Nuske, Marlon, Klusch, Matthias, and Dengel, Andreas
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Quantum Physics ,Computer Science - Computational Complexity ,Computer Science - Discrete Mathematics ,Computer Science - Multiagent Systems - Abstract
The increasing number of Low Earth Orbit (LEO) satellites, driven by lower manufacturing and launch costs, is proving invaluable for Earth observation missions and low-latency internet connectivity. However, as the number of satellites increases, the number of communication links to maintain also rises, making the management of this vast network increasingly challenging and highlighting the need for clustering satellites into efficient groups as a promising solution. This paper formulates the clustering of LEO satellites as a coalition structure generation (CSG) problem and leverages quantum annealing to solve it. We represent the satellite network as a graph and obtain the optimal partitions using a hybrid quantum-classical algorithm called GCS-Q. The algorithm follows a top-down approach by iteratively splitting the graph at each step using a quadratic unconstrained binary optimization (QUBO) formulation. To evaluate our approach, we utilize real-world three-line element set (TLE/3LE) data for Starlink satellites from Celestrak. Our experiments, conducted using the D-Wave Advantage annealer and the state-of-the-art solver Gurobi, demonstrate that the quantum annealer significantly outperforms classical methods in terms of runtime while maintaining the solution quality. The performance achieved with quantum annealers surpasses the capabilities of classical computers, highlighting the transformative potential of quantum computing in optimizing the management of large-scale satellite networks., Comment: 6 pages, 4 figures
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- 2024
5. Quantum Supervised Learning
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Macaluso, Antonio
- Subjects
Computer Science - Machine Learning ,Quantum Physics - Abstract
Recent advancements in quantum computing have positioned it as a prospective solution for tackling intricate computational challenges, with supervised learning emerging as a promising domain for its application. Despite this potential, the field of quantum machine learning is still in its early stages, and there persists a level of skepticism regarding a possible near-term quantum advantage. This paper aims to provide a classical perspective on current quantum algorithms for supervised learning, effectively bridging traditional machine learning principles with advancements in quantum machine learning. Specifically, this study charts a research trajectory that diverges from the predominant focus of quantum machine learning literature, originating from the prerequisites of classical methodologies and elucidating the potential impact of quantum approaches. Through this exploration, our objective is to deepen the understanding of the convergence between classical and quantum methods, thereby laying the groundwork for future advancements in both domains and fostering the involvement of classical practitioners in the field of quantum machine learning., Comment: 16 pages, 3 figures, 1 table
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- 2024
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6. A Benchmark Environment for Offline Reinforcement Learning in Racing Games
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Macaluso, Girolamo, Sestini, Alessandro, and Bagdanov, Andrew D.
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Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Offline Reinforcement Learning (ORL) is a promising approach to reduce the high sample complexity of traditional Reinforcement Learning (RL) by eliminating the need for continuous environmental interactions. ORL exploits a dataset of pre-collected transitions and thus expands the range of application of RL to tasks in which the excessive environment queries increase training time and decrease efficiency, such as in modern AAA games. This paper introduces OfflineMania a novel environment for ORL research. It is inspired by the iconic TrackMania series and developed using the Unity 3D game engine. The environment simulates a single-agent racing game in which the objective is to complete the track through optimal navigation. We provide a variety of datasets to assess ORL performance. These datasets, created from policies of varying ability and in different sizes, aim to offer a challenging testbed for algorithm development and evaluation. We further establish a set of baselines for a range of Online RL, ORL, and hybrid Offline to Online RL approaches using our environment., Comment: Accepted at IEEE Conference on Games
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- 2024
7. Variational Pseudo Marginal Methods for Jet Reconstruction in Particle Physics
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Yang, Hanming, Moretti, Antonio Khalil, Macaluso, Sebastian, Chlenski, Philippe, Naesseth, Christian A., and Pe'er, Itsik
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Computer Science - Machine Learning ,Statistics - Computation - Abstract
Reconstructing jets, which provide vital insights into the properties and histories of subatomic particles produced in high-energy collisions, is a main problem in data analyses in collider physics. This intricate task deals with estimating the latent structure of a jet (binary tree) and involves parameters such as particle energy, momentum, and types. While Bayesian methods offer a natural approach for handling uncertainty and leveraging prior knowledge, they face significant challenges due to the super-exponential growth of potential jet topologies as the number of observed particles increases. To address this, we introduce a Combinatorial Sequential Monte Carlo approach for inferring jet latent structures. As a second contribution, we leverage the resulting estimator to develop a variational inference algorithm for parameter learning. Building on this, we introduce a variational family using a pseudo-marginal framework for a fully Bayesian treatment of all variables, unifying the generative model with the inference process. We illustrate our method's effectiveness through experiments using data generated with a collider physics generative model, highlighting superior speed and accuracy across a range of tasks.
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- 2024
8. Quantum Information Processing with Molecular Nanomagnets: an introduction
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Chiesa, Alessandro, Macaluso, Emilio, and Carretta, Stefano
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Quantum Physics ,Condensed Matter - Materials Science - Abstract
Many problems intractable on classical devices could be solved by algorithms explicitly based on quantum mechanical laws, i.e. exploiting quantum information processing. As a result, increasing efforts from different fields are nowadays directed to the actual realization of quantum devices. Here we provide an introduction to Quantum Information Processing, focusing on a promising setup for its implementation, represented by molecular spin clusters known as Molecular Nanomagnets. We introduce the basic tools to understand and design quantum algorithms, always referring to their actual realization on a molecular spin architecture. We then examine the most important sources of noise in this class of systems and then one of their most peculiar features, i.e. the possibility to exploit many (more than two) available states to encode information and to self-correct it from errors via proper design of quantum error correction codes. Finally, we present some examples of quantum algorithms proposed and implemented on a molecular spin qudit hardware., Comment: After publication, added the sentence: "This is an original manuscript of an article published by Taylor & Francis in Contemporary Physics on 20th of August 2024, available online: https://doi.org/10.1080/00107514.2024.2381952."
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- 2024
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9. Qubit-efficient Variational Quantum Algorithms for Image Segmentation
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Venkatesh, Supreeth Mysore, Macaluso, Antonio, Nuske, Marlon, Klusch, Matthias, and Dengel, Andreas
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Computer Science - Computer Vision and Pattern Recognition ,Electrical Engineering and Systems Science - Image and Video Processing ,Quantum Physics - Abstract
Quantum computing is expected to transform a range of computational tasks beyond the reach of classical algorithms. In this work, we examine the application of variational quantum algorithms (VQAs) for unsupervised image segmentation to partition images into separate semantic regions. Specifically, we formulate the task as a graph cut optimization problem and employ two established qubit-efficient VQAs, which we refer to as Parametric Gate Encoding (PGE) and Ancilla Basis Encoding (ABE), to find the optimal segmentation mask. In addition, we propose Adaptive Cost Encoding (ACE), a new approach that leverages the same circuit architecture as ABE but adopts a problem-dependent cost function. We benchmark PGE, ABE and ACE on synthetically generated images, focusing on quality and trainability. ACE shows consistently faster convergence in training the parameterized quantum circuits in comparison to PGE and ABE. Furthermore, we provide a theoretical analysis of the scalability of these approaches against the Quantum Approximate Optimization Algorithm (QAOA), showing a significant cutback in the quantum resources, especially in the number of qubits that logarithmically depends on the number of pixels. The results validate the strengths of ACE, while concurrently highlighting its inherent limitations and challenges. This paves way for further research in quantum-enhanced computer vision., Comment: 7 pages, 4 figures, 2 tables
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- 2024
10. Toward Automated Programming for Robotic Assembly Using ChatGPT
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Macaluso, Annabella, Cote, Nicholas, and Chitta, Sachin
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Computer Science - Robotics - Abstract
Despite significant technological advancements, the process of programming robots for adaptive assembly remains labor-intensive, demanding expertise in multiple domains and often resulting in task-specific, inflexible code. This work explores the potential of Large Language Models (LLMs), like ChatGPT, to automate this process, leveraging their ability to understand natural language instructions, generalize examples to new tasks, and write code. In this paper, we suggest how these abilities can be harnessed and applied to real-world challenges in the manufacturing industry. We present a novel system that uses ChatGPT to automate the process of programming robots for adaptive assembly by decomposing complex tasks into simpler subtasks, generating robot control code, executing the code in a simulated workcell, and debugging syntax and control errors, such as collisions. We outline the architecture of this system and strategies for task decomposition and code generation. Finally, we demonstrate how our system can autonomously program robots for various assembly tasks in a real-world project.
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- 2024
11. Quantum Convolutional Neural Networks for the detection of Gamma-Ray Bursts in the AGILE space mission data
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Rizzo, A., Parmiggiani, N., Bulgarelli, A., Macaluso, A., Fioretti, V., Castaldini, L., Di Piano, A., Panebianco, G., Pittori, C., Tavani, M., Sartori, C., Burigana, C., Cardone, V., Farsian, F., Meneghetti, M., Murante, G., Scaramella, R., Schillirò, F., Testa, V., and Trombetti, T.
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Astrophysics - High Energy Astrophysical Phenomena ,Computer Science - Artificial Intelligence - Abstract
Quantum computing represents a cutting-edge frontier in artificial intelligence. It makes use of hybrid quantum-classical computation which tries to leverage quantum mechanic principles that allow us to use a different approach to deep learning classification problems. The work presented here falls within the context of the AGILE space mission, launched in 2007 by the Italian Space Agency. We implement different Quantum Convolutional Neural Networks (QCNN) that analyze data acquired by the instruments onboard AGILE to detect Gamma-Ray Bursts from sky maps or light curves. We use several frameworks such as TensorFlow-Quantum, Qiskit and PennyLane to simulate a quantum computer. We achieved an accuracy of 95.1% on sky maps with QCNNs, while the classical counterpart achieved 98.8% on the same data, using however hundreds of thousands more parameters., Comment: 4 pages, 2 figures, proceedings of the ADASS XXXIII (2023) conference, to appear in ASP Conference Serie
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- 2024
12. Deep Learning for AGILE Anticoincidence System's Background Prediction from Orbital and Attitude Parameters
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Parmiggiani, N., Bulgarelli, A., Macaluso, A., Ursi, A., Castaldini, L., Di Piano, A., Falco, R., Fioretti, V., Panebianco, G., Pittori, C., and Tavani, M.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
AGILE is an Italian Space Agency (ASI) space mission launched in 2007 to study X-ray and gamma-ray phenomena in the energy range from $\sim$20 keV to $\sim$10 GeV. The AGILE AntiCoincidence System (ACS) detects hard-X photons in the 50 - 200 keV energy range and continuously stores each panel's count rates in the telemetry. We developed a new Deep Learning (DL) model to predict the background of the AGILE ACS top panel using the satellite's orbital and attitude parameters. This model aims to learn how the orbital and spinning modulations of the satellite impact the background level of the ACS top panel. The DL model executes a regression problem, and is trained with a supervised learning technique on a dataset larger than twenty million orbital parameters' configurations. Using a test dataset, we evaluated the trained model by comparison of the predicted count rates with the real ones. The results show that the model can reconstruct the background count rates of the ACS top panel with an accuracy of 96.7\%, considering the orbital modulation and spinning of the satellite. Starting from these promising results, we are developing an anomaly detection method to detect Gamma-ray Bursts when the differences between predicted and real count rates exceed a predefined threshold., Comment: 4 pages, 2 figure, proceedings of the ADASS XXXIII (2023) conference, to appear in ASP Conference Serie
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- 2024
13. Sim2Real Manipulation on Unknown Objects with Tactile-based Reinforcement Learning
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Su, Entong, Jia, Chengzhe, Qin, Yuzhe, Zhou, Wenxuan, Macaluso, Annabella, Huang, Binghao, and Wang, Xiaolong
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Computer Science - Robotics - Abstract
Using tactile sensors for manipulation remains one of the most challenging problems in robotics. At the heart of these challenges is generalization: How can we train a tactile-based policy that can manipulate unseen and diverse objects? In this paper, we propose to perform Reinforcement Learning with only visual tactile sensing inputs on diverse objects in a physical simulator. By training with diverse objects in simulation, it enables the policy to generalize to unseen objects. However, leveraging simulation introduces the Sim2Real transfer problem. To mitigate this problem, we study different tactile representations and evaluate how each affects real-robot manipulation results after transfer. We conduct our experiments on diverse real-world objects and show significant improvements over baselines for the pivoting task. Our project page is available at https://tactilerl.github.io/.
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- 2024
14. Gender segregation: analysis across sectoral dominance in the UK labour market
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Leoncini, Riccardo, Macaluso, Mariele, and Polselli, Annalivia
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- 2024
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15. Small Dataset, Big Gains: Enhancing Reinforcement Learning by Offline Pre-Training with Model Based Augmentation
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Macaluso, Girolamo, Sestini, Alessandro, and Bagdanov, Andrew D.
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
Offline reinforcement learning leverages pre-collected datasets of transitions to train policies. It can serve as effective initialization for online algorithms, enhancing sample efficiency and speeding up convergence. However, when such datasets are limited in size and quality, offline pre-training can produce sub-optimal policies and lead to degraded online reinforcement learning performance. In this paper we propose a model-based data augmentation strategy to maximize the benefits of offline reinforcement learning pre-training and reduce the scale of data needed to be effective. Our approach leverages a world model of the environment trained on the offline dataset to augment states during offline pre-training. We evaluate our approach on a variety of MuJoCo robotic tasks and our results show it can jump-start online fine-tuning and substantially reduce - in some cases by an order of magnitude - the required number of environment interactions.
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- 2023
16. Successful rechallenge with azacytidine and venetoclax after sustained treatment-free remission in a relapsed acute myeloid leukemia patient: a case report
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Tamellini, E., Simio, C., Bernardelli, A., Ferrarini, I., Vatteroni, A., Moioli, A., Macaluso, V., Marchetti, E., and Tanasi, I.
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- 2024
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17. Comparative effectiveness research trial for antidepressant incomplete and non-responders with treatment resistant depression (ASCERTAIN-TRD) a randomized clinical trial
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Papakostas, George I., Trivedi, Madhukar H., Shelton, Richard C., Iosifescu, Dan V., Thase, Michael E., Jha, Manish K., Mathew, Sanjay J., DeBattista, Charles, Dokucu, Mehmet E., Brawman-Mintzer, Olga, Currier, Glenn W., McCall, William Vaughn, Modirrousta, Mandana, Macaluso, Matthew, Bystritsky, Alexander, Rodriguez, Fidel Vila, Nelson, Erik B., Yeung, Albert S., Feeney, Anna, MacGregor, Leslie C., Carmody, Thomas, and Fava, Maurizio
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- 2024
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18. Q(AI)2: Quantum Artificial Intelligence for the Automotive Industry
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Stollenwerk, Tobias, Bhattacharya, Somtapa, Cattelan, Michele, Ciani, Alessandro, Compostella, Gabriele, Headley, David, Klepsch, Johannes, Klusch, Matthias, Leder, Markus, Macaluso, Antonio, Michielsen, Kristel, Nabok, Dmytro, Papanikolaou, Anestis, Rausch, Alexander, Schumann, Marco, Skolik, Andrea, Yarkoni, Sheir, and Wilhelm, Frank K.
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- 2024
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19. Q-Seg: Quantum Annealing-Based Unsupervised Image Segmentation
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Venkatesh, Supreeth Mysore, Macaluso, Antonio, Nuske, Marlon, Klusch, Matthias, and Dengel, Andreas
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Computer Science - Computer Vision and Pattern Recognition ,Quantum Physics - Abstract
We present Q-Seg, a novel unsupervised image segmentation method based on quantum annealing, tailored for existing quantum hardware. We formulate the pixel-wise segmentation problem, which assimilates spectral and spatial information of the image, as a graph-cut optimization task. Our method efficiently leverages the interconnected qubit topology of the D-Wave Advantage device, offering superior scalability over existing quantum approaches and outperforming several tested state-of-the-art classical methods. Empirical evaluations on synthetic datasets have shown that Q-Seg has better runtime performance than the state-of-the-art classical optimizer Gurobi. The method has also been tested on earth observation image segmentation, a critical area with noisy and unreliable annotations. In the era of noisy intermediate-scale quantum, Q-Seg emerges as a reliable contender for real-world applications in comparison to advanced techniques like Segment Anything. Consequently, Q-Seg offers a promising solution using available quantum hardware, especially in situations constrained by limited labeled data and the need for efficient computational runtime., Comment: 12 pages, 9 figures, 1 table
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- 2023
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20. Nav-Q: Quantum Deep Reinforcement Learning for Collision-Free Navigation of Self-Driving Cars
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Sinha, Akash, Macaluso, Antonio, and Klusch, Matthias
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Quantum Physics ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
The task of collision-free navigation (CFN) of self-driving cars is an NP-hard problem usually tackled using Deep Reinforcement Learning (DRL). While DRL methods have proven to be effective, their implementation requires substantial computing resources and extended training periods to develop a robust agent. On the other hand, quantum reinforcement learning has recently demonstrated faster convergence and improved stability in simple, non-real-world environments. In this work, we propose Nav-Q, the first quantum-supported DRL algorithm for CFN of self-driving cars, that leverages quantum computation for improving the training performance without the requirement for onboard quantum hardware. Nav-Q is based on the actor-critic approach, where the critic is implemented using a hybrid quantum-classical algorithm suitable for near-term quantum devices. We assess the performance of Nav-Q using the CARLA driving simulator, a de facto standard benchmark for evaluating state-of-the-art DRL methods. Our empirical evaluations showcase that Nav-Q surpasses its classical counterpart in terms of training stability and, in certain instances, with respect to the convergence rate. Furthermore, we assess Nav-Q in relation to effective dimension, unveiling that the incorporation of a quantum component results in a model with greater descriptive power compared to classical baselines. Finally, we evaluate the performance of Nav-Q using noisy quantum simulation, observing that the quantum noise deteriorates the training performances but enhances the exploratory tendencies of the agent during training., Comment: 28 pages, 12 figures, 4 tables
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- 2023
21. Large-area polycrystalline $\alpha$-MoO3 thin films for IR photonics
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Larciprete, Maria Cristina, Ceneda, Daniele, Yang, Chiyu, Dereshgi, Sina Abedini, Lupo, Federico Vittorio, Casaletto, Maria Pia, Macaluso, Roberto, Antezza, Mauro, Zhang, Zhuomin M., Centini, Marco, and Aydin, Koray
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Physics - Optics ,Condensed Matter - Materials Science - Abstract
In recent years, excitation of surface phonon polaritons (SPhPs) in van der Waals materials received wide attention from the nanophotonics community. Alpha-phase Molybdenum trioxide ($\alpha$-MoO3), a naturally occurring biaxial hyperbolic crystal, emerged as a promising polaritonic material due to its ability to support SPhPs for three orthogonal directions at different wavelength bands (range 10-20 $\mu$m). Here, we report on the fabrication and IR characterization of large-area (over 1 cm$^2$ size) $\alpha$-MoO3 polycrystalline films deposited on fused silica substrates by pulsed laser deposition. Single alpha-phase MoO3 films exhibiting a polarization-dependent reflection peak at 1006 cm$^{-1}$ with a resonance Q-factor as high as 53 were achieved. Reflection can be tuned via changing incident polarization with a dynamic range of $\Delta$R=0.3 at 45 deg. incidence angle. We also report a polarization-independent almost perfect absorption condition (R<0.01) at 972 cm$^{-1}$ which is preserved for a broad angle of incidence. The development of a low-cost polaritonic platform with high-Q resonances in the mid-infrared (mid-IR) range is crucial for a wide number of functionalities including sensors, filters, thermal emitters, and label-free biochemical sensing devices. In this framework our findings appear extremely promising for the further development of lithography-free, scalable films, for efficient and large-scale devices operating in the free space, using far-field detection setups., Comment: 17 pages, 12 figures
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- 2023
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22. QAL-BP: An Augmented Lagrangian Quantum Approach for Bin Packing
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Cellini, Lorenzo, Macaluso, Antonio, and Lombardi, Michele
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Quantum Physics ,Computer Science - Artificial Intelligence ,Mathematics - Optimization and Control - Abstract
The bin packing is a well-known NP-Hard problem in the domain of artificial intelligence, posing significant challenges in finding efficient solutions. Conversely, recent advancements in quantum technologies have shown promising potential for achieving substantial computational speedup, particularly in certain problem classes, such as combinatorial optimization. In this study, we introduce QAL-BP, a novel Quadratic Unconstrained Binary Optimization (QUBO) formulation designed specifically for bin packing and suitable for quantum computation. QAL-BP utilizes the Augmented Lagrangian method to incorporate the bin packing constraints into the objective function while also facilitating an analytical estimation of heuristic, but empirically robust, penalty multipliers. This approach leads to a more versatile and generalizable model that eliminates the need for empirically calculating instance-dependent Lagrangian coefficients, a requirement commonly encountered in alternative QUBO formulations for similar problems. To assess the effectiveness of our proposed approach, we conduct experiments on a set of bin packing instances using a real Quantum Annealing device. Additionally, we compare the results with those obtained from two different classical solvers, namely simulated annealing and Gurobi. The experimental findings not only confirm the correctness of the proposed formulation but also demonstrate the potential of quantum computation in effectively solving the bin packing problem, particularly as more reliable quantum technology becomes available., Comment: 18 pages, 8 figures, 1 table
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- 2023
23. Active infrared tuning of metal–insulator-metal resonances by VO2 thin film
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Emilija Petronijevic, Maria Cristina Larciprete, Marco Centini, Lucilla Pronti, Vincenzo Aglieri, Luca Razzari, Andrea Toma, Roberto Macaluso, Roberto Li Voti, and Concita Sibilia
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Plasmonics ,Phase change materials ,Metamaterials ,VO2 ,Medicine ,Science - Abstract
Abstract VO2 is a promising phase change material offering a large contrast of electric, thermal, and optical properties when transitioning from semiconductor to metallic phase. Here we show that a hybrid metamaterial obtained by proper combination of a VO2 layer and a nanodisk gold array provides a tunable plasmonic gap resonance in the infrared range. Specifically, we have designed and fabricated a metal–insulator-metal gap resonance by inserting sub-wavelength VO2 film between a flat gold layer and a gold nanodisk resonator array. The resonance of the hybrid metamaterial is centered in the useful 3–5 μm range when VO2 is in its semiconductor state. The experimental study highlights a monotonical spectral tuning of the resonance when increasing temperature up to 50 °C above the room temperature, providing a continuous resonance shift of almost 1 μm in the mid-infrared range. Wavelength range and intensity tunability can be further optimized by modifying the thicknesses of the layers and metamaterial parameters.
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- 2024
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24. An efficient quantum algorithm for ensemble classification using bagging
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Antonio Macaluso, Luca Clissa, Stefano Lodi, and Claudio Sartori
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quantum computing ,quantum computing techniques ,quantum information ,Telecommunication ,TK5101-6720 - Abstract
Abstract Ensemble methods aggregate predictions from multiple models, typically demonstrating improved accuracy and reduced variance compared to individual classifiers. However, they often come with significant memory usage and computational time requirements. A novel quantum algorithm that leverages quantum superposition, entanglement, and interference to construct an ensemble of classification models using bagging as an aggregation strategy is introduced. Through the generation of numerous quantum trajectories in superposition, the authors achieve B transformations of the training set with only logB operations, allowing an exponential enlargement of the ensemble size while linearly increasing the depth of the corresponding circuit. Moreover, when assessing the algorithm's overall cost, the authors demonstrate that the training of a single weak classifier contributes additively to the overall time complexity, as opposed to the multiplicative impact commonly observed in classical ensemble methods. To illustrate the efficacy of the authors’ approach, experiments on reduced real‐world datasets utilising the IBM qiskit environment to demonstrate the functionality and performance of the proposed algorithm are introduced.
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- 2024
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25. GNFactor: Multi-Task Real Robot Learning with Generalizable Neural Feature Fields
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Ze, Yanjie, Yan, Ge, Wu, Yueh-Hua, Macaluso, Annabella, Ge, Yuying, Ye, Jianglong, Hansen, Nicklas, Li, Li Erran, and Wang, Xiaolong
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Computer Science - Robotics ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
It is a long-standing problem in robotics to develop agents capable of executing diverse manipulation tasks from visual observations in unstructured real-world environments. To achieve this goal, the robot needs to have a comprehensive understanding of the 3D structure and semantics of the scene. In this work, we present $\textbf{GNFactor}$, a visual behavior cloning agent for multi-task robotic manipulation with $\textbf{G}$eneralizable $\textbf{N}$eural feature $\textbf{F}$ields. GNFactor jointly optimizes a generalizable neural field (GNF) as a reconstruction module and a Perceiver Transformer as a decision-making module, leveraging a shared deep 3D voxel representation. To incorporate semantics in 3D, the reconstruction module utilizes a vision-language foundation model ($\textit{e.g.}$, Stable Diffusion) to distill rich semantic information into the deep 3D voxel. We evaluate GNFactor on 3 real robot tasks and perform detailed ablations on 10 RLBench tasks with a limited number of demonstrations. We observe a substantial improvement of GNFactor over current state-of-the-art methods in seen and unseen tasks, demonstrating the strong generalization ability of GNFactor. Our project website is https://yanjieze.com/GNFactor/ ., Comment: CoRL 2023 Oral. Website: https://yanjieze.com/GNFactor/
- Published
- 2023
26. Fluorescent Neuronal Cells v2: Multi-Task, Multi-Format Annotations for Deep Learning in Microscopy
- Author
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Clissa, Luca, Macaluso, Antonio, Morelli, Roberto, Occhinegro, Alessandra, Piscitiello, Emiliana, Taddei, Ludovico, Luppi, Marco, Amici, Roberto, Cerri, Matteo, Hitrec, Timna, Rinaldi, Lorenzo, and Zoccoli, Antonio
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning ,Physics - Applied Physics - Abstract
Fluorescent Neuronal Cells v2 is a collection of fluorescence microscopy images and the corresponding ground-truth annotations, designed to foster innovative research in the domains of Life Sciences and Deep Learning. This dataset encompasses three image collections in which rodent neuronal cells' nuclei and cytoplasm are stained with diverse markers to highlight their anatomical or functional characteristics. Alongside the images, we provide ground-truth annotations for several learning tasks, including semantic segmentation, object detection, and counting. The contribution is two-fold. First, given the variety of annotations and their accessible formats, we envision our work facilitating methodological advancements in computer vision approaches for segmentation, detection, feature learning, unsupervised and self-supervised learning, transfer learning, and related areas. Second, by enabling extensive exploration and benchmarking, we hope Fluorescent Neuronal Cells v2 will catalyze breakthroughs in fluorescence microscopy analysis and promote cutting-edge discoveries in life sciences. The data are available at: https://amsacta.unibo.it/id/eprint/7347, Comment: 11 pages; 5 figures; 2 tables
- Published
- 2023
27. WHO-IS: Wireless Hetnet Optimization using Impact Selection
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Sandholm, Thomas, Macaluso, Irene, and Mukherjee, Sayandev
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Computer Science - Networking and Internet Architecture - Abstract
We propose a method to first identify users who have the most negative impact on the overall network performance, and then offload them to an orthogonal channel. The feasibility of such an approach is verified using real-world traces, network simulations, and a lab experiment that employs multi-homed wireless stations. In our experiment, as offload target, we employ LiFi IR transceivers, and as the primary network we consider a typical Enterprise Wi-Fi setup. We found that a limited number of users can impact the overall experience of the Wi-Fi network negatively, hence motivating targeted offloading. In our simulations and experiments we saw that the proposed solution can improve the collision probability with 82% and achieve a 61 percentage point air utilization improvement compared to random offloading, respectively.
- Published
- 2023
28. Composite PCL Scaffold With 70% β-TCP as Suitable Structure for Bone Replacement
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Benedetta Ghezzi, Biagio Matera, Matteo Meglioli, Francesca Rossi, Donatella Duraccio, Maria Giulia Faga, Andrea Zappettini, Guido Maria Macaluso, and Simone Lumetti
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Bone regeneration ,Tissue engineering ,3D printing ,PCL ,β-TCP ,Solvent-free ,Dentistry ,RK1-715 - Abstract
ABSTRACT: Objectives: The purpose of this work was to optimise printable polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) biomaterials with high percentages of β-TCP endowed with balanced mechanical characteristics to resemble human cancellous bone, presumably improving osteogenesis. Methods: PCL/β-TCP scaffolds were obtained from customised filaments for fused deposition modelling (FDM) 3D printing with increasing amounts of β-TCP. Samples mechanical features, surface topography and wettability were evaluated as well as cytocompatibility assays, cell adhesion and differentiation. Results: The parameters of the newly fabricated materila were optimal for PCL/β-TCP scaffold fabrication. Composite surfaces showed higher hydrophilicity compared with the controls, and their surface roughness sharply was higher, possibly due to the presence of β-TCP. The Young's modulus of the composites was significantly higher than that of pristine PCL, indicating that the intrinsic strength of β-TCP is beneficial for enhancing the elastic modulus of the composite biomaterials. All novel composite biomaterials supported greater cellular growth and stronger osteoblastic differentiation compared with the PCL control. Conclusions: This project highlights the possibility to fabricat, through an FDM solvent-free approach, PCL/β-TCP scaffolds of up to 70 % concentrations of β-TCP. overcoming the current lmit of 60 % stated in the literature. The combination of 3D printing and customised biomaterials allowed production of highly personalised scaffolds with optimal mechanical and biological features resembling the natural structure and the composition of bone. This underlines the promise of such structures for innovative approaches for bone and periodontal regeneration.
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- 2024
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29. Active infrared tuning of metal–insulator-metal resonances by VO2 thin film
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Petronijevic, Emilija, Larciprete, Maria Cristina, Centini, Marco, Pronti, Lucilla, Aglieri, Vincenzo, Razzari, Luca, Toma, Andrea, Macaluso, Roberto, Voti, Roberto Li, and Sibilia, Concita
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- 2024
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30. Polarized Raman mapping and phase-transition by CW excitation for fast purely optical characterization of VO2 thin films
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Mussi, V., Bovino, F. A., Falsini, R., Daloiso, D., Lupo, F. V., Kunjumon, R., Voti, R. Li, Cesca, T., Macaluso, R., Sibilia, C., and Mattei, G.
- Published
- 2024
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31. Safety & efficacy of a robotic hip exoskeleton on outpatient stroke rehabilitation
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Macaluso, Rebecca, Giffhorn, Matt, Prokup, Sara, Cleland, Brice, Lee, Jusuk, Lim, Bokman, Lee, Minhyung, Lee, Hwang-Jae, Madhavan, Sangeetha, and Jayaraman, Arun
- Published
- 2024
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- View/download PDF
32. TSG-6+ cancer-associated fibroblasts modulate myeloid cell responses and impair anti-tumor response to immune checkpoint therapy in pancreatic cancer
- Author
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Anandhan, Swetha, Herbrich, Shelley, Goswami, Sangeeta, Guan, Baoxiang, Chen, Yulong, Macaluso, Marc Daniel, Jindal, Sonali, Natarajan, Seanu Meena, Andrewes, Samuel W., Xiong, Liangwen, Nagarajan, Ashwat, Basu, Sreyashi, Tang, Derek Ng, Liu, Jielin, Min, Jimin, Maitra, Anirban, and Sharma, Padmanee
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- 2024
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33. Detecting the symptoms of Parkinson’s disease with non-standard video
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Mifsud, Joseph, Embry, Kyle R., Macaluso, Rebecca, Lonini, Luca, Cotton, R. James, Simuni, Tanya, and Jayaraman, Arun
- Published
- 2024
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34. The influence of the precuneus on the medial temporal cortex determines the subjective quality of memory during the retrieval of naturalistic episodes
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Foudil, Samy-Adrien and Macaluso, Emiliano
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- 2024
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35. QAL-BP: an augmented Lagrangian quantum approach for bin packing
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Cellini, Lorenzo, Macaluso, Antonio, and Lombardi, Michele
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- 2024
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36. Fluorescent Neuronal Cells v2: multi-task, multi-format annotations for deep learning in microscopy
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Clissa, Luca, Macaluso, Antonio, Morelli, Roberto, Occhinegro, Alessandra, Piscitiello, Emiliana, Taddei, Ludovico, Luppi, Marco, Amici, Roberto, Cerri, Matteo, Hitrec, Timna, Rinaldi, Lorenzo, and Zoccoli, Antonio
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- 2024
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37. QuACS: Variational Quantum Algorithm for Coalition Structure Generation in Induced Subgraph Games
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Venkatesh, Supreeth Mysore, Macaluso, Antonio, and Klusch, Matthias
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Quantum Physics ,Computer Science - Computer Science and Game Theory - Abstract
Coalition Structure Generation (CSG) is an NP-Hard problem in which agents are partitioned into mutually exclusive groups to maximize their social welfare. In this work, we propose QuACS, a novel hybrid quantum classical algorithm for Coalition Structure Generation in Induced Subgraph Games (ISGs). Starting from a coalition structure where all the agents belong to a single coalition, QuACS recursively identifies the optimal partition into two disjoint subsets. This problem is reformulated as a QUBO and then solved using QAOA. Given an $n$-agent ISG, we show that the proposed algorithm outperforms existing approximate classical solvers with a runtime of $\mathcal{O}(n^2)$ and an expected approximation ratio of $92\%$. Furthermore, it requires a significantly lower number of qubits and allows experiments on medium-sized problems compared to existing quantum solutions. To show the effectiveness of QuACS we perform experiments on standard benchmark datasets using quantum simulation., Comment: 7 pages, 2 figures, 1 table
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- 2023
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38. MAQA: A Quantum Framework for Supervised Learning
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Macaluso, Antonio, Klusch, Matthias, Lodi, Stefano, and Sartori, Claudio
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Quantum Physics ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Quantum Machine Learning has the potential to improve traditional machine learning methods and overcome some of the main limitations imposed by the classical computing paradigm. However, the practical advantages of using quantum resources to solve pattern recognition tasks are still to be demonstrated. This work proposes a universal, efficient framework that can reproduce the output of a plethora of classical supervised machine learning algorithms exploiting quantum computation's advantages. The proposed framework is named Multiple Aggregator Quantum Algorithm (MAQA) due to its capability to combine multiple and diverse functions to solve typical supervised learning problems. In its general formulation, MAQA can be potentially adopted as the quantum counterpart of all those models falling into the scheme of aggregation of multiple functions, such as ensemble algorithms and neural networks. From a computational point of view, the proposed framework allows generating an exponentially large number of different transformations of the input at the cost of increasing the depth of the corresponding quantum circuit linearly. Thus, MAQA produces a model with substantial descriptive power to broaden the horizon of possible applications of quantum machine learning with a computational advantage over classical methods. As a second meaningful addition, we discuss the adoption of the proposed framework as hybrid quantum-classical and fault-tolerant quantum algorithm., Comment: 1 Figure
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- 2023
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39. Quantum Splines for Non-Linear Approximations
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Macaluso, Antonio, Clissa, Luca, Lodi, Stefano, and Sartori, Claudio
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Quantum Physics ,Computer Science - Machine Learning - Abstract
Quantum Computing offers a new paradigm for efficient computing and many AI applications could benefit from its potential boost in performance. However, the main limitation is the constraint to linear operations that hampers the representation of complex relationships in data. In this work, we propose an efficient implementation of quantum splines for non-linear approximation. In particular, we first discuss possible parametrisations, and select the most convenient for exploiting the HHL algorithm to obtain the estimates of spline coefficients. Then, we investigate QSpline performance as an evaluation routine for some of the most popular activation functions adopted in ML. Finally, a detailed comparison with classical alternatives to the HHL is also presented., Comment: 6 pages, 3 figures, 2 tables
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- 2023
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40. Gender Segregation: Analysis across Sectoral-Dominance in the UK Labour Market
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Leoncini, Riccardo, Macaluso, Mariele, and Polselli, Annalivia
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Economics - General Economics - Abstract
This paper aims to evaluate how changing patterns of sectoral gender segregation play a role in accounting for women's employment contracts and wages in the UK between 2005 and 2020. We then study wage differentials in gender-specific dominated sectors. We found that the propensity of women to be distributed differently across sectors is a major factor contributing to explaining the differences in wages and contract opportunities. Hence, the disproportion of women in female-dominated sectors implies contractual features and lower wages typical of that sector, on average, for all workers. This difference is primarily explained by "persistent discriminatory constraints", while human capital-related characteristics play a minor role. However, wage differentials would shrink if workers had the same potential and residual wages as men in male-dominated sectors. Moreover, this does not happen at the top of the wage distribution, where wage differentials among women working in female-dominated sectors are always more pronounced than those of men., Comment: 22 pages, 6 tables and 5 figures in text
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- 2023
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41. Enabling Non-Linear Quantum Operations through Variational Quantum Splines
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Inajetovic, Matteo Antonio, Orazi, Filippo, Macaluso, Antonio, Lodi, Stefano, and Sartori, Claudio
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Quantum Physics ,Computer Science - Machine Learning - Abstract
The postulates of quantum mechanics impose only unitary transformations on quantum states, which is a severe limitation for quantum machine learning algorithms. Quantum Splines (QSplines) have recently been proposed to approximate quantum activation functions to introduce non-linearity in quantum algorithms. However, QSplines make use of the HHL as a subroutine and require a fault-tolerant quantum computer to be correctly implemented. This work proposes the Generalised Hybrid Quantum Splines (GHQSplines), a novel method for approximating non-linear quantum activation functions using hybrid quantum-classical computation. The GHQSplines overcome the highly demanding requirements of the original QSplines in terms of quantum hardware and can be implemented using near-term quantum computers. Furthermore, the proposed method relies on a flexible problem representation for non-linear approximation and it is suitable to be embedded in existing quantum neural network architectures. In addition, we provide a practical implementation of the GHQSplines using Pennylane and show that our model outperforms the original QSplines in terms of quality of fitting.
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- 2023
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42. Polarized Raman mapping and phase-transition by CW excitation for fast purely optical characterization of VO2 thin films
- Author
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V. Mussi, F. A. Bovino, R. Falsini, D. Daloiso, F. V. Lupo, R. Kunjumon, R. Li Voti, T. Cesca, R. Macaluso, C. Sibilia, and G. Mattei
- Subjects
VO2 thin films ,Phase transition ,Polarized Raman ,Continuous wave excitation ,Medicine ,Science - Abstract
Abstract Vanadium dioxide has attracted much interest due to the drastic change of the electrical and optical properties it exhibits during the transition from the semiconductor state to the metallic state, which takes place at a critical temperature of about 68 °C. Much study has been especially devoted to developing advanced fabrication methodologies to improve the performance of VO2 thin films for phase-change applications in optical devices. Films structural and morphological characterisation is normally performed with expensive and time consuming equipment, as x-ray diffractometers, electron microscopes and atomic force microscopes. Here we propose a purely optical approach which combines Polarized Raman Mapping and Phase-Transition by Continuous Wave Optical Excitation (PTCWE) to acquire through two simple measurements structural, morphological and thermal behaviour information on polycrystalline VO2 thin films. The combination of the two techniques allows to reconstruct a complete picture of the properties of the films in a fast and effective manner, and also to unveil an interesting stepped appearance of the hysteresis cycles probably induced by the progressive stabilization of rutile metallic domains embedded in the semiconducting monoclinic matrix.
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- 2024
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43. Safety & efficacy of a robotic hip exoskeleton on outpatient stroke rehabilitation
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Rebecca Macaluso, Matt Giffhorn, Sara Prokup, Brice Cleland, Jusuk Lee, Bokman Lim, Minhyung Lee, Hwang-Jae Lee, Sangeetha Madhavan, and Arun Jayaraman
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Stroke rehabilitation ,Exoskeleton ,Gait training ,Outpatient ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Objective The objective of this study was to analyze the safety and efficacy of using a robotic hip exoskeleton designed by Samsung Electronics Co., Ltd., Korea, called the Gait Enhancing and Motivating System-Hip (GEMS-H), in assistance mode only with the poststroke population in an outpatient-rehabilitation setting. Methods Forty-one participants with an average age of 60 and average stroke latency of 6.5 years completed this prospective, single arm, interventional, longitudinal study during the COVID-19 pandemic. Significant modifications to the traditional outpatient clinical environment were made to adhere to organizational physical distancing policies as well as guidelines from the Centers for Disease Control. All participants received gait training with the GEMS-H in assistance mode for 18 training sessions over the course of 6–8 weeks. Performance-based and self-reported clinical outcomes were assessed at four time points: baseline, midpoint (after 9 training sessions), post (after 18 training sessions), and 1-month follow up. Daily step count was also collected throughout the duration of the study using an ankle-worn actigraphy device. Additionally, corticomotor excitability was measured at baseline and post for 4 bilateral lower limb muscles using transcranial magnetic stimulation. Results By the end of the training program, the primary outcome, walking speed, improved by 0.13 m/s (p
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- 2024
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44. TSG-6+ cancer-associated fibroblasts modulate myeloid cell responses and impair anti-tumor response to immune checkpoint therapy in pancreatic cancer
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Swetha Anandhan, Shelley Herbrich, Sangeeta Goswami, Baoxiang Guan, Yulong Chen, Marc Daniel Macaluso, Sonali Jindal, Seanu Meena Natarajan, Samuel W. Andrewes, Liangwen Xiong, Ashwat Nagarajan, Sreyashi Basu, Derek Ng Tang, Jielin Liu, Jimin Min, Anirban Maitra, and Padmanee Sharma
- Subjects
Science - Abstract
Abstract Resistance to immune checkpoint therapy (ICT) presents a growing clinical challenge. The tumor microenvironment (TME) and its components, namely tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs), play a pivotal role in ICT resistance; however, the underlying mechanisms remain under investigation. In this study, we identify expression of TNF-Stimulated Factor 6 (TSG-6) in ICT-resistant pancreatic tumors, compared to ICT-sensitive melanoma tumors, both in mouse and human. TSG-6 is expressed by CAFs within the TME, where suppressive macrophages expressing Arg1, Mafb, and Mrc1, along with TSG-6 ligand Cd44, predominate. Furthermore, TSG-6 expressing CAFs co-localize with the CD44 expressing macrophages in the TME. TSG-6 inhibition in combination with ICT improves therapy response and survival in pancreatic tumor-bearing mice by reducing macrophages expressing immunosuppressive phenotypes and increasing CD8 T cells. Overall, our findings propose TSG-6 as a therapeutic target to enhance ICT response in non-responsive tumors.
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- 2024
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45. mTORC2-NDRG1-CDC42 axis couples fasting to mitochondrial fission.
- Author
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Mattar, Pamela, Toledo, Miriam, Bains, Henrietta, Kalyani, Manu, Aoun, Marie, Sharma, Mridul, McIntire, Laura, Gunther-Cummins, Leslie, Macaluso, Frank, Aguilan, Jennifer, Sidoli, Simone, Bourdenx, Mathieu, Singh, Rajat, and Martinez-Lopez, Nuria
- Subjects
Mechanistic Target of Rapamycin Complex 2 ,TOR Serine-Threonine Kinases ,Mitochondrial Dynamics ,Carrier Proteins ,Phosphorylation ,Fasting - Abstract
Fasting triggers diverse physiological adaptations including increases in circulating fatty acids and mitochondrial respiration to facilitate organismal survival. The mechanisms driving mitochondrial adaptations and respiratory sufficiency during fasting remain incompletely understood. Here we show that fasting or lipid availability stimulates mTORC2 activity. Activation of mTORC2 and phosphorylation of its downstream target NDRG1 at serine 336 sustains mitochondrial fission and respiratory sufficiency. Time-lapse imaging shows that NDRG1, but not the phosphorylation-deficient NDRG1Ser336Ala mutant, engages with mitochondria to facilitate fission in control cells, as well as in those lacking DRP1. Using proteomics, a small interfering RNA screen, and epistasis experiments, we show that mTORC2-phosphorylated NDRG1 cooperates with small GTPase CDC42 and effectors and regulators of CDC42 to orchestrate fission. Accordingly, RictorKO, NDRG1Ser336Ala mutants and Cdc42-deficient cells each display mitochondrial phenotypes reminiscent of fission failure. During nutrient surplus, mTOR complexes perform anabolic functions; however, paradoxical reactivation of mTORC2 during fasting unexpectedly drives mitochondrial fission and respiration.
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- 2023
46. Alzheimer’s-Associated Upregulation of Mitochondria-Associated ER Membranes After Traumatic Brain Injury
- Author
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Agrawal, Rishi R, Larrea, Delfina, Xu, Yimeng, Shi, Lingyan, Zirpoli, Hylde, Cummins, Leslie G, Emmanuele, Valentina, Song, Donghui, Yun, Taekyung D, Macaluso, Frank P, Min, Wei, Kernie, Steven G, Deckelbaum, Richard J, and Area-Gomez, Estela
- Subjects
Biochemistry and Cell Biology ,Biological Sciences ,Neurodegenerative ,Neurosciences ,Alzheimer's Disease ,Traumatic Head and Spine Injury ,Dementia ,Physical Injury - Accidents and Adverse Effects ,Aging ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Brain Disorders ,Traumatic Brain Injury (TBI) ,Acquired Cognitive Impairment ,Aetiology ,2.1 Biological and endogenous factors ,1.1 Normal biological development and functioning ,Underpinning research ,Neurological ,Mice ,Animals ,Alzheimer Disease ,Mitochondria ,Up-Regulation ,Endoplasmic Reticulum ,Amyloid beta-Protein Precursor ,Brain Injuries ,Traumatic ,Lipids ,Brain injury ,Neurodegeneration ,Alzheimer's ,Contact sites ,Alzheimer’s ,Pharmacology and Pharmaceutical Sciences ,Neurology & Neurosurgery ,Biochemistry and cell biology - Abstract
Traumatic brain injury (TBI) can lead to neurodegenerative diseases such as Alzheimer's disease (AD) through mechanisms that remain incompletely characterized. Similar to AD, TBI models present with cellular metabolic alterations and modulated cleavage of amyloid precursor protein (APP). Specifically, AD and TBI tissues display increases in amyloid-β as well as its precursor, the APP C-terminal fragment of 99 a.a. (C99). Our recent data in cell models of AD indicate that C99, due to its affinity for cholesterol, induces the formation of transient lipid raft domains in the ER known as mitochondria-associated endoplasmic reticulum (ER) membranes ("MAM" domains). The formation of these domains recruits and activates specific lipid metabolic enzymes that regulate cellular cholesterol trafficking and sphingolipid turnover. Increased C99 levels in AD cell models promote MAM formation and significantly modulate cellular lipid homeostasis. Here, these phenotypes were recapitulated in the controlled cortical impact (CCI) model of TBI in adult mice. Specifically, the injured cortex and hippocampus displayed significant increases in C99 and MAM activity, as measured by phospholipid synthesis, sphingomyelinase activity and cholesterol turnover. In addition, our cell type-specific lipidomics analyses revealed significant changes in microglial lipid composition that are consistent with the observed alterations in MAM-resident enzymes. Altogether, we propose that alterations in the regulation of MAM and relevant lipid metabolic pathways could contribute to the epidemiological connection between TBI and AD.
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- 2023
47. Cultural Intelligence in the Diverse Classroom
- Author
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Macaluso, Ann M.
- Abstract
It cannot be denied that our world has become increasingly interconnected. Improvements in transportation together with advances in technology have provided opportunities for individuals to explore the world beyond geographic and economic boundaries. Add in a global pandemic that forced individuals to interact via the Internet and you see the further erosion of boundaries and a recognition that life today can be essentially flat. A flattened world has fewer borders and allows for a fluid flow of people, goods, and services across national boundaries. To be successful in this flattened world, individuals must be culturally competent. Cultural competence is the ability to fluidly interact with individuals from other cultures and diverse backgrounds (Villagran & Hawamdeh, 2020). The purpose of this study was to identify if immigrant students lived multicultural experiences provided them with the competencies necessary for successful participation in an interconnected world. Participants were high school students in a large, diverse suburban public high school in the Northeast United States. Surveys were administered in-class via pencil and paper to students in general education and bilingual Social Studies classes. This non-experimental study utilized Earley and Ang's (2003) Cultural Intelligence Scale (CQS) to assess student's global competencies. The results of the study revealed that a student's immigrant generational status is related to their level of cultural intelligence. These results suggest that immigrant students, compared to their nonimmigrant peers, may already have the globally desired skills, values, knowledge, and attitudes necessary to be highly successful leaders of tomorrow.
- Published
- 2022
48. Preliminary Results of a New Deep Learning Method to Detect and Localize GRBs in the AGILE/GRID Sky Maps
- Author
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Parmiggiani, N., Bulgarelli, A., Macaluso, A., Fioretti, V., Di Piano, A., Baroncelli, L., Addis, A., Landoni, M., Pittori, C., Verrecchia, F., Lucarelli, F., Giuliani, A., Longo, F., Beneventano, D., and Tavani, M.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
AGILE is an ASI space mission launched in 2007 to study X-ray and gamma-ray phenomena in the energy range from $\sim20$ keV to $\sim10$ GeV. The AGILE Team developed a real-time analysis pipeline for the fast detection of transient sources, and the follow-up of external science alerts received through networks such as the General Coordinates Network. We developed a new Deep Learning method for detecting and localizing Gamma-Ray Bursts (GRB) in the AGILE/GRID sky maps. We trained the model using sky maps with GRBs simulated in a radius of 20 degrees from the center of the map, which is larger than 99.5 \% of the error region present in the GRBWeb catalog. We also plan to apply this method to search for counterparts of gravitational wave events, which typically have a wider localization error region. The method comprises two Deep Learning models implemented with two Convolutional Neural Networks. The first model detects and filters sky maps containing a GRB, while the second model localizes its position. We trained and tested the models using simulated data. The detection model achieves an accuracy of 95.7 \%, and the localization model has a mean error lower than 0.8 degrees. We configured a Docker container with all the required software for data simulation and deployed it using the Amazon Web Service to calculate the p-value distribution under different conditions. With the p-value distribution, we can calculate the statistical significance of a detection., Comment: 4 pages, 1 figure, proceedings of the ADASS XXXII (2022) conference, to appear in ASP Conference Serie
- Published
- 2023
49. Preliminary Results of a Deep Learning Anomaly Detection Method to Identify Gamma-Ray Bursts in the AGILE Anticoincidence System
- Author
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Parmiggiani, N., Bulgarelli, A., Ursi, A., Tavani, M., Macaluso, A., Di Piano, A., Fioretti, V., Baroncelli, L., Addis, A., and Pittori, C.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
AGILE is a space mission launched in 2007 to study X-ray and gamma-ray astronomy. The AGILE team developed real-time analysis pipelines to detect transient phenomena such as Gamma-Ray Bursts (GRBs) and to react to external science alerts received by other facilities. The AGILE anti-coincidence system (ACS) comprises five panels (four lateral and one on the top) that surround the AGILE detectors to reject background charged particles. It can also detect hard X-ray photons in the energy range 50 - 200 KeV. The acquisition of the ACS data produces a time series for each panel. These time series can be merged in a single multivariate time series (MTS). We present in this work a new Deep Learning model for GRBs detection in the MTSs, generated by the ACS, using an anomaly detection technique. The model is implemented with a Deep Convolutional Neural Network autoencoder architecture. We trained the model with an unsupervised learning algorithm using a dataset of MTSs randomly extracted from the AGILE ACS data. The reconstruction error of the autoencoder is used as the anomaly score to classify the MTS. If the anomaly score is higher than a predefined threshold, the MTS is flagged as a GRB. The trained model is evaluated using a list of MTSs containing GRBs. The tests confirmed the model's ability to detect transient events, providing a new promising technique to identify GRBs in the ACS data that can be implemented in the AGILE real-time analysis pipeline., Comment: 4 pages, 1 figure, proceedings of the ADASS XXXI (2021) conference, to appear in ASP Conference Serie
- Published
- 2023
50. GCS-Q: Quantum Graph Coalition Structure Generation
- Author
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Venkatesh, Supreeth Mysore, Macaluso, Antonio, and Klusch, Matthias
- Subjects
Quantum Physics ,Computer Science - Artificial Intelligence ,Computer Science - Multiagent Systems - Abstract
The problem of generating an optimal coalition structure for a given coalition game of rational agents is to find a partition that maximizes their social welfare and is known to be NP-hard. This paper proposes GCS-Q, a novel quantum-supported solution for Induced Subgraph Games (ISGs) in coalition structure generation. GCS-Q starts by considering the grand coalition as initial coalition structure and proceeds by iteratively splitting the coalitions into two nonempty subsets to obtain a coalition structure with a higher coalition value. In particular, given an $n$-agent ISG, the GCS-Q solves the optimal split problem $\mathcal{O} (n)$ times using a quantum annealing device, exploring $\mathcal{O}(2^n)$ partitions at each step. We show that GCS-Q outperforms the currently best classical solvers with its runtime in the order of $n^2$ and an expected worst-case approximation ratio of $93\%$ on standard benchmark datasets., Comment: 6 pages, 3 figures
- Published
- 2022
- Full Text
- View/download PDF
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