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408 results on '"MacLean, Margaret R."'

7. The Role of Sex in the Pathophysiology of Pulmonary Hypertension

Author

Docherty, Craig K., Harvey, Katie Yates, Mair, Kirsty M., Griffin, Sinead, Denver, Nina, MacLean, Margaret R., COHEN, IRUN R., Series Editor, LAJTHA, ABEL, Series Editor, LAMBRIS, JOHN D., Series Editor, PAOLETTI, RODOLFO, Series Editor, REZAEI, NIMA, Series Editor, Kerkhof, Peter L. M., editor, and Miller, Virginia M., editor

Published
2018
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10. Serotonin and Pulmonary Hypertension; Sex and Drugs and ROCK and Rho

Author

MacLean, Margaret R, Fanburg, Barry, Hill, Nicolas, Lazarus, Howard M., Pack, Thomas F., Palacios, Michelle, Penumatsa, Krishna C., and Wring, Stephen A.

Subjects
Serotonin Plasma Membrane Transport Proteins, Serotonin, Hypertension, Pulmonary, Myocytes, Smooth Muscle, Endothelial Cells, Humans, Pulmonary Artery, QP, Cell Proliferation
Abstract

Serotonin is often referred to as a "happy hormone" as it maintains good mood, well-being, and happiness. It is involved in communication between nerve cells and plays a role in sleeping and digestion. However, too much serotonin can have pathogenic effects and serotonin synthesis is elevated in pulmonary artery endothelial cells from patients with pulmonary arterial hypertension (PAH). PAH is characterized by elevated pulmonary pressures, right ventricular failure, inflammation, and pulmonary vascular remodeling; serotonin has been shown to be associated with these pathologies. The rate-limiting enzyme in the synthesis of serotonin in the periphery of the body is tryptophan hydroxylase 1 (TPH1). TPH1 expression and serotonin synthesis are elevated in pulmonary artery endothelial cells in patients with PAH. The serotonin synthesized in the pulmonary arterial endothelium can act on the adjacent pulmonary arterial smooth muscle cells (PASMCs), adventitial macrophages, and fibroblasts, in a paracrine fashion. In humans, serotonin enters PASMCs cells via the serotonin transporter (SERT) and it can cooperate with the 5-HT1B receptor on the plasma membrane; this activates both contractile and proliferative signaling pathways. The "serotonin hypothesis of pulmonary hypertension" arose when serotonin was associated with PAH induced by diet pills such as fenfluramine, aminorex, and chlorphentermine; these act as indirect serotonergic agonists causing the release of serotonin from platelets and cells through the SERT. Here the role of serotonin in PAH is reviewed. Targeting serotonin synthesis or signaling is a promising novel alternative approach which may lead to novel therapies for PAH. © 2022 American Physiological Society. Compr Physiol 12: 1-16, 2022.

Published
2022

11. Urotensin receptor in GtoPdb v.2023.1

Author

Davenport, Anthony P., primary, Douglas, Stephen A., primary, Fournier, Alain, primary, Giaid, Adel, primary, Krum, Henry, primary, Lambert, David G., primary, Leprince, Jérôme, primary, MacLean, Margaret R., primary, Ohlstein, Eliot H., primary, Thomas, Walter G., primary, Tostivint, Hervé, primary, Vaudry, David, primary, Vaudry, Hubert, primary, and Webb, David J., primary

Published
2023
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13. A pilot study to examine association of BMI with functional class and six minute walk distance in idiopathic and heritable PAH : possible association with estrogen metabolism

Author

MacLean, Margaret R., Pandya, Divya, Swietlik, Emilia M., Denver, Nina, Mair, Kirsty, Morrell, Nicholas W., and Gräf, Stefan

Subjects
RA773
Abstract

The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1‐pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for heritable pulmonary arterial/idiopathic PAH suggests increased BMI is a predictor of worse functional class and shorter 6MWD; increased body‐weight in mice and man may be associated with increased estrogen metabolism.

Published
2022

21. Urotensin receptor in GtoPdb v.2021.3

Author

Davenport, Anthony P., primary, Douglas, Stephen A., primary, Fournier, Alain, primary, Giaid, Adel, primary, Krum, Henry, primary, Lambert, David G., primary, Leprince, Jérôme, primary, MacLean, Margaret R., primary, Ohlstein, Eliot H., primary, Thomas, Walter G., primary, Tostivint, Hervé, primary, Vaudry, David, primary, Vaudry, Hubert, primary, and Webb, David J., primary

Published
2021
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28. A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism.

Author

MacLean, Margaret R., Pandya, Divya, Swietlik, Emilia M., Denver, Nina, Mair, Kirsty, Morrell, Nicholas W., and Gräf, Stefan

Subjects
*ESTROGEN, *BODY mass index, *PILOT projects, *METABOLISM
Abstract

The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1‐pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for heritable pulmonary arterial/idiopathic PAH suggests increased BMI is a predictor of worse functional class and shorter 6MWD; increased body‐weight in mice and man may be associated with increased estrogen metabolism. [ABSTRACT FROM AUTHOR]

Published
2022
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29. ENHANCING INTERACTIONS BETWEEN MASR AND ETBR AS A NEW VASOPROTECTIVE STRATEGY

Author

Kuriakose, Jithin, primary, Montezano, Augusto C, additional, Hood, Katie Y, additional, Alves-Lopes, Rheure, additional, Sin, Angie Yy, additional, Passaglia, Patricia, additional, Finaly, Jane E, additional, Basheer, Sehrish, additional, Yusuf, Hiba, additional, Hepburn, Ross, additional, Santos, Robson A, additional, Maclean, Margaret R, additional, Baillie, George S, additional, and Touyz, Rhian M, additional

Published
2021
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31. Insights from the Menstrual Cycle in Pulmonary Arterial Hypertension

Author

Baird, Grayson L., primary, Walsh, Thomas, additional, Aliotta, Jason, additional, Allahua, Melissa, additional, Andrew, Ruth, additional, Bourjeily, Ghada, additional, Brodsky, Alexander S., additional, Denver, Nina, additional, Dooner, Mark, additional, Harrington, Elizabeth O., additional, Klinger, James R., additional, MacLean, Margaret R., additional, Mullin, Christopher J., additional, Pereira, Mandy, additional, Poppas, Athena, additional, Whittenhall, Mary, additional, and Ventetuolo, Corey E., additional

Published
2021
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32. sj-pdf-1-pul-10.1177_2045894020922810 - Supplemental material for Apoptosis signal-regulating kinase 1 inhibition in in vivo and in vitro models of pulmonary hypertension

Author

Wilson, Kathryn S., Buist, Hanna, Suveizdyte, Kornelija, Liles, John T., Budas, Grant R., Hughes, Colin, MacLean, Margaret R., Johnson, Martin, Church, Alistair C., Peacock, Andrew J., and Welsh, David J.

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, education, Cardiology, humanities
Abstract

Supplemental material, sj-pdf-1-pul-10.1177_2045894020922810 for Apoptosis signal-regulating kinase 1 inhibition in in vivo and in vitro models of pulmonary hypertension by Kathryn S. Wilson, Hanna Buist, Kornelija Suveizdyte, John T. Liles, Grant R. Budas, Colin Hughes, Margaret R. MacLean, Martin Johnson, Alistair C. Church, Andrew J. Peacock and David J. Welsh in Pulmonary Circulation

Published
2020
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33. Notch3 signaling and vascular remodeling in pulmonary arterial hypertension

Author

Morris, Hannah, Neves, Karla B., Montezano, Augusto C., Maclean, Margaret R., and Touyz, Rhian

Subjects
cardiovascular system
Abstract

Notch signalling is critically involved in vascular morphogenesis and function. Four Notch isoforms (Notch1–4) regulating diverse cellular processes have been identified. Of these, Notch3 is expressed almost exclusively in vascular smooth muscle cells (VSMCs), where it is critically involved in vascular development and differentiation. Under pathological conditions, Notch3 regulates VSMC switching between the contractile and synthetic phenotypes. Abnormal Notch3 signalling plays an important role in vascular remodelling, a hallmark of several cardiovascular diseases, including pulmonary arterial hypertension (PAH). Because of the importance of Notch3 in VSMC (de)differentiation, Notch3 has been implicated in the pathophysiology of pulmonary vascular remodelling in PAH. Here we review the current literature on the role of Notch in VSMC function with a focus on Notch3 signalling in pulmonary artery VSMCs, and discuss potential implications in pulmonary artery remodelling in PAH.

Published
2019

36. Imatinib Attenuates Hypoxia-induced Pulmonary Arterial Hypertension Pathology via Reduction in 5-Hydroxytryptamine through Inhibition of Tryptophan Hydroxylase 1 Expression

Author

Ciuclan, Loredana, Hussey, Martin J., Burton, Victoria, Good, Robert, Duggan, Nicholas, Beach, Sarah, Jones, Peter, Fox, Roy, Clay, Ieuan, Bonneau, Olivier, Konstantinova, Irena, Pearce, Andrew, Rowlands, David J., Jarai, Gabor, Westwick, John, MacLean, Margaret R., and Thomas, Matthew

Published
2013
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48. Fulvestrant for the Treatment of Pulmonary Arterial Hypertension

Author

Kawut, Steven M., primary, Pinder, Diane, additional, Al-Naamani, Nadine, additional, McCormick, Amber, additional, Palevsky, Harold I., additional, Fritz, Jason, additional, Smith, K. Akaya, additional, Mazurek, Jeremy A., additional, Doyle, Margaret F., additional, MacLean, Margaret R., additional, DeMichele, Angela, additional, and Mankoff, David A., additional

Published
2019
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50. Pulmonary hypertension, anorexigens and 5-HT: pharmacological synergism in action?

Author

MacLean, Margaret R.

Subjects
Pulmonary hypertension -- Research, Weight reducing preparations -- Physiological aspects, Vasoconstrictors -- Physiological aspects, Serotonin -- Physiological aspects, Neurotransmitter receptors -- Physiological aspects, Biological sciences, Chemistry, Pharmaceuticals and cosmetics industries
Abstract

In pulmonary hypertension (PHT), pulmonary vascular resistance is elevated as a result of increased pulmonary vascular tone and pulmonary vascular remodelling. Certain diet pills, such as the fenfluramines, have been associated with the development of PHT. This class of drugs act as indirect 5-HT receptor agonists and can inhibit 5-HT reuptake and cause the release of 5-HT from platelets. Many pulmonary vasoconstrictors, including 5-HT, activate both G(sub i)- and G(sub q)-linked receptors. Increasing evidence suggests that G(sub q) activation might amplify G(sub i)-linked intracellular pathways to 'uncover' or potentiate vasoconstrictor responses - a phenomenon known as pharmacological synergism, which occurs in the pulmonary circulation. In this review the evidence that 5-HT plays a role in PHT and that pharmacological synergism might contribute to its pathology is discussed.

Published
1999

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