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23 results on '"MacLachlan, N.J."'

6. Induction of type I diabetes by interferon-alpha in transgenic mice

Author

Stewart, T.A., Hultgren, B., Huang, X., Pitts-Meek, S., Hully, J., and MacLachlan, N.J.

Subjects
Physiological aspects, Diabetes mellitus -- Physiological aspects, Interferon alpha -- Physiological aspects, Diabetes -- Physiological aspects
Abstract

Type I diabetes is caused by the progressive loss of pancreatic Β cells and is associated with several autoimmune phenomena (1). Although particular alleles closely linked to the major histocompatibility [...], Type I diabetes is an autoimmune disease involving an interaction between an epigenetic event (possibly a viral infection), the pancreatic Β cells, and the immune system in a genetically susceptible host. The possibility that the type I interferons could mediate this interaction was tested with transgenic mice in which the insulin-producing cells expressed an interferon-[Alpha]. These mice developed a hypoinsulinemic diabetes associated with a mixed inflammation centered on the islets. The inflammation and the diabetes were prevented with a neutralizing antibody to the interferon-[Alpha]. Thus, the expression of interferon-a by the cells could be causal in the development of type I diabetes, which suggests a therapeutic approach to this disease.

Published
1993

10. Bluetongue

Author

MACLACHLAN, N.J., primary, MAYO, C.E., additional, DANIELS, P.W., additional, SAVINI, G., additional, ZIENTARA, S., additional, and GIBBS, E.P.J., additional

Published
2015
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