Search

Your search keyword '"MacDonald, Lauren A."' showing total 140 results
Start Over Author "MacDonald, Lauren A."
140 results on '"MacDonald, Lauren A."'

1. Study protocol for Psilocybin in patients with fibromyalgia: brain biomarkers of action.

Author

Bornemann, Julia, Close, James, Ahmad, Kirran, Barba, Tommaso, Godfrey, Kate, Macdonald, Lauren, Erritzoe, David, Nutt, David, and Carhart-Harris, Robin

Subjects
EEG, chronic pain, fibromyalgia, psilocybin, psychedelic therapy
Abstract

BACKGROUND: Chronic pain is a leading cause of disability worldwide. Fibromyalgia is a particularly debilitating form of widespread chronic pain. Fibromyalgia remains poorly understood, and treatment options are limited or moderately effective at best. Here, we present a protocol for a mechanistic study investigating the effects of psychedelic-assisted-therapy in a fibromyalgia population. The principal focus of this trial is the central mechanism(s) of psilocybin-therapy i.e., in the brain and on associated mental schemata, primarily captured by electroencephalography (EEG) recordings of the acute psychedelic state, plus pre and post Magnetic Resonance Imaging (MRI). METHODS: Twenty participants with fibromyalgia will complete 8 study visits over 8 weeks. This will include two dosing sessions where participants will receive psilocybin at least once, with doses varying up to 25mg. Our primary outcomes are 1) Lempel-Ziv complexity (LZc) recorded acutely using EEG, and the 2) the (Brief Experiential Avoidance Questionnaire (BEAQ) measured at baseline and primary endpoint. Secondary outcomes will aim to capture broad aspects of the pain experience and related features through neuroimaging, self-report measures, behavioural paradigms, and qualitative interviews. Pain Symptomatology will be measured using the Brief Pain Inventory Interference Subscale (BPI-IS), physical and mental health-related function will be measured using the 36-Item Short Form Health Survey (SF-36). Further neurobiological investigations will include functional MRI (fMRI) and diffusion tensor imaging (changes from baseline to primary endpoint), and acute changes in pre- vs post-acute spontaneous brain activity - plus event-related potential functional plasticity markers, captured via EEG. DISCUSSION: The results of this study will provide valuable insight into the brain mechanisms involved in the action of psilocybin-therapy for fibromyalgia with potential implications for the therapeutic action of psychedelic-therapy more broadly. It will also deliver essential data to inform the design of a potential subsequent RCT.

Published
2024

8. Snakebite incidence and healthcare-seeking behaviors in Eastern Province, Rwanda: A cross-sectional study.

Author

Hakizimana, Dieudonne, MacDonald, Lauren E., Kampire, Happy Tahirih, Bonaventure, Mihigo, Tadesse, Mahlet, Murara, Elijah, Dusabe, Leila, Ishema, Leandre, and Schurer, Janna M.

Subjects
*COMMUNITY health workers, *HEALERS, *RESOURCE-limited settings, *MEDICAL personnel, *PUBLIC officers, *SNAKEBITES
Abstract

Background: Snakebite envenoming (SBE) is a potentially life-threatening event that can lead to severe physical, mental, and economic hardships, particularly in under-resourced regions like sub-Saharan Africa. In Rwanda, there have been no epidemiological assessments of SBE to guide the Ministry of Health in its efforts to reduce the burden. This study had two main objectives: first, to estimate the incidence of snakebites across districts, and second, to describe formal versus informal healthcare seeking behaviors among snakebite victims in Eastern Province, Rwanda in 2020. Methodology: This cross-sectional study utilized a cluster sampling approach, involving Community Health Workers (CHWs) who recorded snakebite cases across seven districts. The descriptive analysis considered sampling weights, and healthcare seeking behavior was assessed based on the type of care sought as the first point of treatment. Findings: The study surveyed 390,546 individuals across 763 villages and estimated a provincial annual incidence rate of 4.3 cases per 1,000 individuals. Incidence estimates ranged from 1.1 cases per 1,000 in Nyagatare to 9.1 cases per 1,000 individuals in Bugesera and Ngoma districts. Among the 2,545 cases recorded by CHWs, three resulted in deaths. Regarding healthcare-seeking behavior, 13% of snakebite victims (143 out of 1,098) initially consulted formal care providers (CHWs, health post/center, or hospital), while 87% sought informal care (family/friends, pharmacist, or traditional healer). Approximately half of the victims (583, 53.1%) reported severe symptoms. Unsafe practices included skin cutting/burning, tourniquet application, use of black stones, and venom extraction; only 24 cases (2.2%) received anti-venom. Conclusions: This large-scale community-based assessment highlights variations in snakebite incidence between districts and confirms frequent involvement of traditional healers in management. Improving access to anti-venom and community education on the risks of ineffective practices, along with timely use of formal healthcare, are crucial. Collaboration between healthcare providers, traditional healers, community leaders, and policymakers is essential to implement targeted interventions for enhancing snakebite prevention and management strategies. Author summary: Snakebites can be life-threatening, especially in places like sub-Saharan Africa. In Rwanda, there haven't been any studies to understand how many snakebites happen and where they happen. This study wanted to find out two main things: first, how many snakebites happened in different parts of the Eastern Province of Rwanda in 2020, and second, where people who got bitten by snakes went for help—to doctors or traditional healers. The study involved 390,546 people across 763 villages. It found that each year, about 4.3 out of 1,000 people in the province get bitten by snakes, but the numbers vary in different areas. Surprisingly, only 13% of the victims initially consulted formal healthcare providers like community health workers, health centers, or hospitals. In contrast, a larger group, 87%, sought informal care from family, friends, pharmacists, or traditional healers first. About half of the people bitten by snakes experienced severe symptoms. Unfortunately, many people used unsafe methods to treat snakebites, like cutting or burning the skin, tying a tight band around the bitten area, using black stones, or trying to suck out the venom. Only a very small number of cases, just 24 out of all 1,098 victims, received anti-venom. The study suggests we need to make sure anti-venom is easier to get and teach communities about the risks of unsafe practices and why it's important to get formal healthcare quickly. It's important for doctors, traditional healers, community leaders, and government officials to work together to make sure people get safe and appropriate treatment and learn how to prevent snakebites. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Disseminating information on acute public health events globally: experiences from the WHO’s Disease Outbreak News

Author

Lata, Harsh, primary, Saad Duque, Neil Jan, additional, Togami, Eri, additional, Miglietta, Alessandro, additional, Perkins, Devin, additional, Corpuz, Aura, additional, Kato, Masaya, additional, Babu, Amarnath, additional, Dorji, Tshewang, additional, Matsui, Tamano, additional, Almiron, Maria, additional, Cheng, Ka Yeung, additional, MacDonald, Lauren E, additional, Pukkila, Jukka Tapani, additional, Williams, George Sie, additional, Andraghetti, Roberta, additional, Dolea, Carmen, additional, Mahamud, Abdirahman, additional, Morgan, Oliver, additional, Olowokure, Babatunde, additional, Fall, Ibrahima Socé, additional, Awofisayo-Okuyelu, Adedoyin, additional, and Hamblion, Esther, additional

Published
2024
Full Text
View/download PDF

19. Additional Materials and Methods from Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Author

Tucker, Douglass W., primary, Getchell, Christopher R., primary, McCarthy, Eric T., primary, Ohman, Anders W., primary, Sasamoto, Naoko, primary, Xu, Shuyun, primary, Ko, Joo Yeon, primary, Gupta, Mamta, primary, Shafrir, Amy, primary, Medina, Jamie E., primary, Lee, Jonathan J., primary, MacDonald, Lauren A., primary, Malik, Ammara, primary, Hasselblatt, Kathleen T, primary, Li, Wenjing, primary, Zhang, Hong, primary, Kaplan, Samuel J., primary, Murphy, George F., primary, Hirsch, Michelle S., primary, Liu, Joyce F., primary, Matulonis, Ursula A., primary, Terry, Kathryn L., primary, Lian, Christine G., primary, and Dinulescu, Daniela M., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Figure 3 from Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Author

Tucker, Douglass W., primary, Getchell, Christopher R., primary, McCarthy, Eric T., primary, Ohman, Anders W., primary, Sasamoto, Naoko, primary, Xu, Shuyun, primary, Ko, Joo Yeon, primary, Gupta, Mamta, primary, Shafrir, Amy, primary, Medina, Jamie E., primary, Lee, Jonathan J., primary, MacDonald, Lauren A., primary, Malik, Ammara, primary, Hasselblatt, Kathleen T, primary, Li, Wenjing, primary, Zhang, Hong, primary, Kaplan, Samuel J., primary, Murphy, George F., primary, Hirsch, Michelle S., primary, Liu, Joyce F., primary, Matulonis, Ursula A., primary, Terry, Kathryn L., primary, Lian, Christine G., primary, and Dinulescu, Daniela M., primary

Published
2023
Full Text
View/download PDF

21. Supplementary Figure 4 from Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Author

Tucker, Douglass W., primary, Getchell, Christopher R., primary, McCarthy, Eric T., primary, Ohman, Anders W., primary, Sasamoto, Naoko, primary, Xu, Shuyun, primary, Ko, Joo Yeon, primary, Gupta, Mamta, primary, Shafrir, Amy, primary, Medina, Jamie E., primary, Lee, Jonathan J., primary, MacDonald, Lauren A., primary, Malik, Ammara, primary, Hasselblatt, Kathleen T, primary, Li, Wenjing, primary, Zhang, Hong, primary, Kaplan, Samuel J., primary, Murphy, George F., primary, Hirsch, Michelle S., primary, Liu, Joyce F., primary, Matulonis, Ursula A., primary, Terry, Kathryn L., primary, Lian, Christine G., primary, and Dinulescu, Daniela M., primary

Published
2023
Full Text
View/download PDF

22. Supplementary Figure 1 from Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Author

Tucker, Douglass W., primary, Getchell, Christopher R., primary, McCarthy, Eric T., primary, Ohman, Anders W., primary, Sasamoto, Naoko, primary, Xu, Shuyun, primary, Ko, Joo Yeon, primary, Gupta, Mamta, primary, Shafrir, Amy, primary, Medina, Jamie E., primary, Lee, Jonathan J., primary, MacDonald, Lauren A., primary, Malik, Ammara, primary, Hasselblatt, Kathleen T, primary, Li, Wenjing, primary, Zhang, Hong, primary, Kaplan, Samuel J., primary, Murphy, George F., primary, Hirsch, Michelle S., primary, Liu, Joyce F., primary, Matulonis, Ursula A., primary, Terry, Kathryn L., primary, Lian, Christine G., primary, and Dinulescu, Daniela M., primary

Published
2023
Full Text
View/download PDF

23. Supplementary Figure 2 from Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Author

Tucker, Douglass W., primary, Getchell, Christopher R., primary, McCarthy, Eric T., primary, Ohman, Anders W., primary, Sasamoto, Naoko, primary, Xu, Shuyun, primary, Ko, Joo Yeon, primary, Gupta, Mamta, primary, Shafrir, Amy, primary, Medina, Jamie E., primary, Lee, Jonathan J., primary, MacDonald, Lauren A., primary, Malik, Ammara, primary, Hasselblatt, Kathleen T, primary, Li, Wenjing, primary, Zhang, Hong, primary, Kaplan, Samuel J., primary, Murphy, George F., primary, Hirsch, Michelle S., primary, Liu, Joyce F., primary, Matulonis, Ursula A., primary, Terry, Kathryn L., primary, Lian, Christine G., primary, and Dinulescu, Daniela M., primary

Published
2023
Full Text
View/download PDF

24. Supplementary Table 1 from Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Author

Tucker, Douglass W., primary, Getchell, Christopher R., primary, McCarthy, Eric T., primary, Ohman, Anders W., primary, Sasamoto, Naoko, primary, Xu, Shuyun, primary, Ko, Joo Yeon, primary, Gupta, Mamta, primary, Shafrir, Amy, primary, Medina, Jamie E., primary, Lee, Jonathan J., primary, MacDonald, Lauren A., primary, Malik, Ammara, primary, Hasselblatt, Kathleen T, primary, Li, Wenjing, primary, Zhang, Hong, primary, Kaplan, Samuel J., primary, Murphy, George F., primary, Hirsch, Michelle S., primary, Liu, Joyce F., primary, Matulonis, Ursula A., primary, Terry, Kathryn L., primary, Lian, Christine G., primary, and Dinulescu, Daniela M., primary

Published
2023
Full Text
View/download PDF

25. Supplementary Table 2 from Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Author

Tucker, Douglass W., primary, Getchell, Christopher R., primary, McCarthy, Eric T., primary, Ohman, Anders W., primary, Sasamoto, Naoko, primary, Xu, Shuyun, primary, Ko, Joo Yeon, primary, Gupta, Mamta, primary, Shafrir, Amy, primary, Medina, Jamie E., primary, Lee, Jonathan J., primary, MacDonald, Lauren A., primary, Malik, Ammara, primary, Hasselblatt, Kathleen T, primary, Li, Wenjing, primary, Zhang, Hong, primary, Kaplan, Samuel J., primary, Murphy, George F., primary, Hirsch, Michelle S., primary, Liu, Joyce F., primary, Matulonis, Ursula A., primary, Terry, Kathryn L., primary, Lian, Christine G., primary, and Dinulescu, Daniela M., primary

Published
2023
Full Text
View/download PDF

26. Data from Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Author

Tucker, Douglass W., primary, Getchell, Christopher R., primary, McCarthy, Eric T., primary, Ohman, Anders W., primary, Sasamoto, Naoko, primary, Xu, Shuyun, primary, Ko, Joo Yeon, primary, Gupta, Mamta, primary, Shafrir, Amy, primary, Medina, Jamie E., primary, Lee, Jonathan J., primary, MacDonald, Lauren A., primary, Malik, Ammara, primary, Hasselblatt, Kathleen T, primary, Li, Wenjing, primary, Zhang, Hong, primary, Kaplan, Samuel J., primary, Murphy, George F., primary, Hirsch, Michelle S., primary, Liu, Joyce F., primary, Matulonis, Ursula A., primary, Terry, Kathryn L., primary, Lian, Christine G., primary, and Dinulescu, Daniela M., primary

Published
2023
Full Text
View/download PDF

27. Supplementary Figure 5 from Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Author

Tucker, Douglass W., primary, Getchell, Christopher R., primary, McCarthy, Eric T., primary, Ohman, Anders W., primary, Sasamoto, Naoko, primary, Xu, Shuyun, primary, Ko, Joo Yeon, primary, Gupta, Mamta, primary, Shafrir, Amy, primary, Medina, Jamie E., primary, Lee, Jonathan J., primary, MacDonald, Lauren A., primary, Malik, Ammara, primary, Hasselblatt, Kathleen T, primary, Li, Wenjing, primary, Zhang, Hong, primary, Kaplan, Samuel J., primary, Murphy, George F., primary, Hirsch, Michelle S., primary, Liu, Joyce F., primary, Matulonis, Ursula A., primary, Terry, Kathryn L., primary, Lian, Christine G., primary, and Dinulescu, Daniela M., primary

Published
2023
Full Text
View/download PDF

32. Paleolimnological evaluation of metal(loid) enrichment from oil sands and gold mining operations in northwestern Canada

Author

Kay, Mitchell L., primary, Jasiak, Izabela, additional, Klemt, Wynona H., additional, Wiklund, Johan A., additional, Faber, Jelle A., additional, MacDonald, Lauren A., additional, Telford, James V.K., additional, Savage, Cory A.M., additional, Cooke, Colin A., additional, Wolfe, Brent B., additional, and Hall, Roland I., additional

Published
2023
Full Text
View/download PDF

33. The World Health Organization’s public health intelligence activities during the COVID-19 pandemic response, December 2019 to December 2021

Author

Togami, Eri, primary, Griffith, Bridget, additional, Mahran, Mostafa, additional, Nezu, Ingrid H, additional, Mirembe, Bernadette B, additional, Kaasik-Aaslav, Kaja, additional, Alexandrova-Ezerska, Lidia, additional, Babu, Amarnath, additional, Sedai, Tika Ram, additional, Kato, Masaya, additional, Abbas, Heidi, additional, Sadek, Mahmoud, additional, Nabeth, Pierre, additional, MacDonald, Lauren E., additional, Hernández-García, Lucía, additional, Pires, Jeffrey, additional, Ildefonso, Stefany, additional, Stephen, Mary, additional, Lee, Theresa Min-Hyung, additional, Impouma, Benido, additional, Matsui, Tamano, additional, Moon, Sangjun, additional, Phenxay, Manilay, additional, Biaukula, Viema, additional, Ochirpurev, Ariuntuya, additional, Schnitzler, Johannes, additional, Fontaine, Julie, additional, Djordjevic, Irena, additional, Brindle, Hannah, additional, Kolmer, Jessica, additional, McMenamin, Martina, additional, Peron, Emilie, additional, Kassamali, Zyleen, additional, Greene-Cramer, Blanche, additional, Hamblion, Esther, additional, Abdelmalik, Philip, additional, Pavlin, Boris I, additional, Mahamud, Abdi Rahman, additional, and Morgan, Oliver, additional

Published
2022
Full Text
View/download PDF

34. sj-docx-1-sci-10.1177_00368504231181452 - Supplemental material for Ecosystem responses of shallow thermokarst lakes to climate-driven hydrological change: Insights from long-term monitoring of periphytic diatom community composition at Old Crow Flats (Yukon, Canada)

Author

Mohammed, Wathiq J, MacDonald, Lauren A, Thomas, Kathryn E, McDonald, Ian, Turner, Kevin W, Wolfe, Brent B, and Hall, Roland I

Subjects
FOS: Biological sciences, 69999 Biological Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-1-sci-10.1177_00368504231181452 for Ecosystem responses of shallow thermokarst lakes to climate-driven hydrological change: Insights from long-term monitoring of periphytic diatom community composition at Old Crow Flats (Yukon, Canada) by Wathiq J Mohammed, Lauren A MacDonald, Kathryn E Thomas, Ian McDonald, Kevin W Turner, Brent B Wolfe and Roland I Hall in Science Progress

Published
2023
Full Text
View/download PDF

35. Appendix 1

Author

Kreisler, Rachael E, MacDonald, Lauren J, Mensing, Rachel N, Hoffmann, Emma R, Keary, Carissa G, Padilla, Kayla N, and Norris, Jeffrey W

Subjects
70706 Veterinary Medicine, FOS: Veterinary sciences
Abstract

‘Kitten mitten’ pilot survey

Published
2023
Full Text
View/download PDF

39. Appendix 2

Author

Dalrymple, Aimee M, MacDonald, Lauren J, and Kreisler, Rachael E

Subjects
70706 Veterinary Medicine, FOS: Veterinary sciences, otorhinolaryngologic diseases, sense organs, health care economics and organizations
Abstract

Estimated cost per cat, in ascending order, for various reported ear–tip hemostasis methods.

Published
2022
Full Text
View/download PDF

40. Appendix 1

Author

Dalrymple, Aimee M, MacDonald, Lauren J, and Kreisler, Rachael E

Subjects
70706 Veterinary Medicine, FOS: Veterinary sciences, otorhinolaryngologic diseases, sense organs
Abstract

Survey questionnaire regarding ear-tipping practices for identification of cats sterilized via trap–neuter–return programs.

Published
2022
Full Text
View/download PDF

42. A Bayesian mixing model framework for quantifying temporal variation in source of sediment to lakes across broad hydrological gradients of floodplains

Author

Kay, Mitchell L., primary, Swanson, Heidi K., additional, Burbank, Jacob, additional, Owca, Tanner J., additional, MacDonald, Lauren A., additional, Savage, Cory A. M., additional, Remmer, Casey R., additional, Neary, Laura K., additional, Wiklund, Johan A., additional, Wolfe, Brent B., additional, and Hall, Roland I., additional

Published
2021
Full Text
View/download PDF

44. A Bayesian mixing model framework for quantifying temporal and spatial variation in source of sediment to lakes across hydrological gradients of floodplains

Author

Kay, Mitchell, primary, Swanson, Heidi, additional, Burbank, Jacob, additional, Owca, Tanner, additional, MacDonald, Lauren, additional, Savage, Cory, additional, Remmer, Casey, additional, Neary, Laura, additional, Wiklund, Johan, additional, Wolfe, Brent, additional, and Hall, Roland, additional

Published
2021
Full Text
View/download PDF

45. Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8+ T cells compared with women with BRCA wild‑type disease during the early disease course

Author

Lee, Jung‑Min, primary, Botesteanu, Dana‑Adriana, additional, Tomita, Yusuke, additional, Yuno, Akira, additional, Lee, Min‑Jung, additional, Kohn, Elise, additional, Annunziata, Christina, additional, Matulonis, Ursula, additional, MacDonald, Lauren, additional, Nair, Jayakumar, additional, Macneil, Kimberley, additional, and Trepel, Jane, additional

Published
2019
Full Text
View/download PDF

47. Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Author

Tucker, Douglass W., primary, Getchell, Christopher R., additional, McCarthy, Eric T., additional, Ohman, Anders W., additional, Sasamoto, Naoko, additional, Xu, Shuyun, additional, Ko, Joo Yeon, additional, Gupta, Mamta, additional, Shafrir, Amy, additional, Medina, Jamie E., additional, Lee, Jonathan J., additional, MacDonald, Lauren A., additional, Malik, Ammara, additional, Hasselblatt, Kathleen T, additional, Li, Wenjing, additional, Zhang, Hong, additional, Kaplan, Samuel J., additional, Murphy, George F., additional, Hirsch, Michelle S., additional, Liu, Joyce F., additional, Matulonis, Ursula A., additional, Terry, Kathryn L., additional, Lian, Christine G., additional, and Dinulescu, Daniela M., additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results