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6 results on '"Maćkowska-Maślak, Natalia"'

3. Pre-clinical evaluation of the hypomethylating agent decitabine for the treatment of t-cell lymphoblastic lymphoma

Author

Provez, Lien, Putteman, Tom, Landfors, Mattias, Roels, Juliette, Reunes, Lindy, T’Sas, Sara, Van Loocke, Wouter, Lintermans, Béatrice, De Coninck, Stien, Thenoz, Morgan, Sleeckx, Wouter, Maćkowska-Maślak, Natalia, Taghon, Tom, Mansour, Marc R., Farah, Nadine, Norga, Koen, Vandenberghe, Peter, Kotecha, Rishi S., Goossens, Steven, Degerman, Sofie, De Smedt, Renate, Van Vlierberghe, Pieter, Provez, Lien, Putteman, Tom, Landfors, Mattias, Roels, Juliette, Reunes, Lindy, T’Sas, Sara, Van Loocke, Wouter, Lintermans, Béatrice, De Coninck, Stien, Thenoz, Morgan, Sleeckx, Wouter, Maćkowska-Maślak, Natalia, Taghon, Tom, Mansour, Marc R., Farah, Nadine, Norga, Koen, Vandenberghe, Peter, Kotecha, Rishi S., Goossens, Steven, Degerman, Sofie, De Smedt, Renate, and Van Vlierberghe, Pieter

Abstract

T-cell lymphoblastic lymphoma (T-LBL) is a rare and aggressive lymphatic cancer, often diagnosed at a young age. Patients are treated with intensive chemotherapy, potentially followed by a hematopoietic stem cell transplantation. Although prognosis of T-LBL has improved with intensified treatment protocols, they are associated with side effects and 10–20% of patients still die from relapsed or refractory disease. Given this, the search toward less toxic anti-lymphoma therapies is ongoing. Here, we targeted the recently described DNA hypermethylated profile in T-LBL with the DNA hypomethylating agent decitabine. We evaluated the anti-lymphoma properties and downstream effects of decitabine, using patient derived xenograft (PDX) models. Decitabine treatment resulted in prolonged lymphoma-free survival in all T-LBL PDX models, which was associated with downregulation of the oncogenic MYC pathway. However, some PDX models showed more benefit of decitabine treatment compared to others. In more sensitive models, differentially methylated CpG regions resulted in more differentially expressed genes in open chromatin regions. This resulted in stronger downregulation of cell cycle genes and upregulation of immune response activating transcripts. Finally, we suggest a gene signature for high decitabine sensitivity in T-LBL. Altogether, we here delivered pre-clinical proof of the potential use of decitabine as a new therapeutic agent in T-LBL.

Published
2023
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4. Pre-Clinical Evaluation of the Hypomethylating Agent Decitabine for the Treatment of T-Cell Lymphoblastic Lymphoma

Author

Provez, Lien, primary, Putteman, Tom, additional, Landfors, Mattias, additional, Roels, Juliette, additional, Reunes, Lindy, additional, T’Sas, Sara, additional, Van Loocke, Wouter, additional, Lintermans, Béatrice, additional, De Coninck, Stien, additional, Thenoz, Morgan, additional, Sleeckx, Wouter, additional, Maćkowska-Maślak, Natalia, additional, Taghon, Tom, additional, Mansour, Marc R., additional, Farah, Nadine, additional, Norga, Koen, additional, Vandenberghe, Peter, additional, Kotecha, Rishi S., additional, Goossens, Steven, additional, Degerman, Sofie, additional, De Smedt, Renate, additional, and Van Vlierberghe, Pieter, additional

Published
2023
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5. Small RNA-Seq Reveals Similar miRNA Transcriptome in Children and Young Adults with T-ALL and Indicates miR-143-3p as Novel Candidate Tumor Suppressor in This Leukemia

Author

Dawidowska, Małgorzata, primary, Maćkowska-Maślak, Natalia, additional, Drobna-Śledzińska, Monika, additional, Kosmalska, Maria, additional, Jaksik, Roman, additional, Szymczak, Donata, additional, Jarmuż-Szymczak, Małgorzata, additional, Sadowska-Klasa, Alicja, additional, Wojtaszewska, Marzena, additional, Sędek, Łukasz, additional, Wróbel, Tomasz, additional, Zaucha, Jan Maciej, additional, Szczepański, Tomasz, additional, Lewandowski, Krzysztof, additional, Giebel, Sebastian, additional, and Witt, Michał, additional

Published
2022
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6. Multiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 in pediatric T‐ALL: Focus on miR‐363‐3p and promoter methylation

Author

Drobna‐Śledzińska, Monika, primary, Maćkowska‐Maślak, Natalia, additional, Jaksik, Roman, additional, Kosmalska, Maria, additional, Szarzyńska, Bronisława, additional, Lejman, Monika, additional, Sędek, Łukasz, additional, Szczepański, Tomasz, additional, Taghon, Tom, additional, Van Vlierberghe, Pieter, additional, Witt, Michał, additional, and Dawidowska, Małgorzata, additional

Published
2022
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