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2. Curation and expansion of the Human Phenotype Ontology for systemic autoinflammatory diseases improves phenotype-driven disease-matching.

Author

Maassen, W., Legger, G., Kul Cinar, O., Daele, P. van, Gattorno, M., Bader-Meunier, B., Wouters, C., Briggs, T., Johansson, L., Velde, J. van der, Swertz, M., Omoyinmi, E., Hoppenreijs, E.P., Belot, A., Eleftheriou, D., Caorsi, R., Aeschlimann, F., Boursier, G., Brogan, P., Haimel, M., Gijn, M. van, Maassen, W., Legger, G., Kul Cinar, O., Daele, P. van, Gattorno, M., Bader-Meunier, B., Wouters, C., Briggs, T., Johansson, L., Velde, J. van der, Swertz, M., Omoyinmi, E., Hoppenreijs, E.P., Belot, A., Eleftheriou, D., Caorsi, R., Aeschlimann, F., Boursier, G., Brogan, P., Haimel, M., and Gijn, M. van

Abstract

Item does not contain fulltext, INTRODUCTION: Accurate and standardized phenotypic descriptions are essential in diagnosing rare diseases and discovering new diseases, and the Human Phenotype Ontology (HPO) system was developed to provide a rich collection of hierarchical phenotypic descriptions. However, although the HPO terms for inborn errors of immunity have been improved and curated, it has not been investigated whether this curation improves the diagnosis of systemic autoinflammatory disease (SAID) patients. Here, we aimed to study if improved HPO annotation for SAIDs enhanced SAID identification and to demonstrate the potential of phenotype-driven genome diagnostics using curated HPO terms for SAIDs. METHODS: We collected HPO terms from 98 genetically confirmed SAID patients across eight different European SAID expertise centers and used the LIRICAL (Likelihood Ratio Interpretation of Clinical Abnormalities) computational algorithm to estimate the effect of HPO curation on the prioritization of the correct SAID for each patient. RESULTS: Our results show that the percentage of correct diagnoses increased from 66% to 86% and that the number of diagnoses with the highest ranking increased from 38 to 45. In a further pilot study, curation also improved HPO-based whole-exome sequencing (WES) analysis, diagnosing 10/12 patients before and 12/12 after curation. In addition, the average number of candidate diseases that needed to be interpreted decreased from 35 to 2. DISCUSSION: This study demonstrates that curation of HPO terms can increase identification of the correct diagnosis, emphasizing the high potential of HPO-based genome diagnostics for SAIDs.

Published
2023

6. Supraklavikuläre Lymphknotenbiopsie, Mediastinoskopie

Author

Maaßen, W., Buchborn, E., editor, Austgen, M., editor, Beckenkamp, H.-W., editor, Brandt, H.-J., editor, Dold, U., editor, Dürschmied, H., editor, Dundalek, E., editor, Felix, R., editor, Georgi, P., editor, Herold, H.-J., editor, Hilgard, P., editor, Jacob, W., editor, Klein, H. O., editor, Konietzko, N., editor, Loddenkemper, R., editor, Maaßen, W., editor, Matsui, E., editor, Matthiessen, W., editor, Meents, H., editor, Müller, K.-M., editor, Ostertag, H., editor, Schlimmer, P., editor, Schmähl, D., editor, Schober, R., editor, Wegener, O. H., editor, Wolfart, W., editor, Zeller, W. J., editor, and Trendelenburg, Friedrich, editor

Published
1985
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7. Die chirurgische Behandlung der thorakalen Tuberkulose

Author

Maassen, W., Schwiegk, H., editor, Bartmann, K., editor, Bube, F. W., editor, Dundalek, E., editor, Jentgens, Heinrich, editor, Jungbluth, H., editor, Lock, W., editor, Maaßen, W., editor, Popp, L., editor, Reimers, D., editor, Schwabe, K. H., editor, Simon, K., editor, and Wandelt-Freerksen, E., editor

Published
1981
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8. Compliance with antimalarial chemoprophylaxis in German soldiers: a 6-year survey

Author

Hagen Rm, Holtherm Hu, Erkens K, Vorderwülbecke F, Hagen Frickmann, Maassen W, Norbert Georg Schwarz, Fischer M, and Morwinsky T

Subjects
Adult, Male, Microbiology (medical), Health Knowledge, Attitudes, Practice, Pediatrics, medicine.medical_specialty, Adolescent, Health knowledge, Chemoprevention, Compliance (psychology), German, Antimalarials, Young Adult, Protective Clothing, Surveys and Questionnaires, Environmental health, parasitic diseases, medicine, Animals, Humans, Patient compliance, Mosquito Nets, business.industry, Germany, West, Insect Bites and Stings, General Medicine, medicine.disease, language.human_language, Malaria, Military Personnel, Infectious Diseases, Chemoprophylaxis, language, Patient Compliance, Female, business
Abstract

Since 1992, German soldiers have been deployed in areas where malaria is endemic. Antimalarial chemoprophylaxis (CP) is directed according to the assessed risk and is provided free of charge. Compliance is crucial if its effect is to be reliable. This study analysed compliance with directed CP in German soldiers as well as its determinants.Between 2003 and 2009, standardized questionnaire-based interviews were performed with 2,149 out of approximately 100,000 German soldiers who were deployed during this period in areas where malaria is endemic. The questionnaires dealt with information that the soldiers had received about malaria prior to their missions, with their adherence to mosquito-protective and antimalarial chemoprophylactic procedures, and their estimations of their individual level of exposure.About 1,308 out of 2,149 interviewed soldiers had been ordered to take CP, allowing for an assessment of the outcome parameter "CP-compliance". About 76.9 % out of 1,308 soldiers to whom regular CP was directed took it regularly. The exposure variables "age", "satisfaction with malaria counselling", "perceived threat due to insects or mosquitoes" and "use of insect repellents" were positively associated with compliance with directed antimalarial CP.The study confirms the findings of the French and US armies that even free-of-charge access to antimalarial medication will not lead to 100 % acceptance. The compliance problem is aggravated by the generally low age of deployed soldiers. Adequate counselling is crucial to increase adherence to antimalarial CP.

Published
2013
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13. Onkologie

Author

Kohl, F. V., Rüdiger, H. W., von Wichert, P., Niederle, N., Nakhosteen, J. A., Maaßen, W., Seeber, S., Schmidt, C. G., Liesenfeld, A., Havemann, K., Gropp, C., Gassel, W. D., Trauth, H., Becker, E., Thomas, C., Drings, P., Mahnke, H. G., Nagel, G., Fischer, M., Mitrou, P. S., Georgii, A., Weißenfels, A., Queisser, M., Konrad, R. M., Westerhausen, M., Wellens, W., Dudeck, J., Luster, W., Ostendorf, P., Keppler, K., Kleine-Hakenkamp, B., Wernet, P., Pflüger, K. H., Gramse, M., Ho, A. D., Gless, A. H., Hunstein, W., Pfreundschuh, M., Manegold, C., Herrmann, R., Fritze, D., Krempien, B., Munz, D., Hör, G., Aiginger, P., Schwarz, H. P., Kolbe, H., Kuzmits, R., Kühböck, J., Mayr, W. R., Spona, J., Hacke, M., Alt, J., Schmoll, H. J., Stolte, H., Illiger, H. J., Schmidt, R. E., Hartlapp, J. H., Müllerleile, U., Bieber, K. D., Garbrecht, M., Hanrath, P., Lüthje, M., Andreesen, R., Oepke, G., Modolell, M., Runge, M., Löhr, G. W., Munder, P. G., and Miehlke, K., editor

Published
1981
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17. Verschiedenes

Author

Silló-Seidl, Georg, Winkhaus, I., Scholze, R., Steinbeck, H., Kaiser, R., Mickan, H., Rjosk, H. K., Eversmann, I., Zander, J., Broer, K. H., Winkhaus, I., Kaiser, R., Knabe, H., Schade, A., Hackelöer, B. -J., Nitschke, S., Daume, E., Sturm, G., Buchholz, R., Meyenburg, M., Krajnović, P., Smiljanić, N., Gašparac, B., Bernoth, E., Link, M., Weise, W., Donat, H., Kapitza, W., stauber, M., stadler, C., Hardt, W., Maaßen, W., Farkas, G., Silló-Seidl, G., Berendes, R., Winkhaus, I., Bolte, A., Propping, D., Tauber, P. F., Katzorke, Th., Lübke, F., Schmidt-Elmendorff, H., Steyer, M., Steuber, H. G., Broer, K. H., Kaiser, R., Krebs, D., Springer, N., Lehmann, F., Hackelöer, B. -J., Robinson, H. P., Baranyai, E., Váradi, I., Keller, E., Zubke, W., Göser, R., and Schindler, A. E.

Published
1979
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22. Korte Samenvattingen

Author

Schmidlin, O. P., primary, Drion, H., additional, Maassen, W. W. J., additional, Zeelenberg, J. H. G., additional, van Rooijen, J. P., additional, and Köster, H. K., additional

Published
1963
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46. Die transsternale und -perikardiale Verschlußoperation bei Hauptbronchusstumpffisteln und Pleuraempyem

Author

Maassen W

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Lung resections, medicine.medical_treatment, Fistula, Bronchopleural fistula, respiratory system, medicine.disease, respiratory tract diseases, Surgery, Pneumonectomy, Main Bronchus, medicine, Radiology, Lung resection, Cardiology and Cardiovascular Medicine, business, Surgical treatment
Abstract

The management of bronchopleural fistula after lung resection is discussed. The transsternal and transpericardial approach for surgical treatment of fistulas of the main bronchus after pneumonectomy is described. In 4 cases of 2000 lung resections occurred a bronchopleural fistula after right pneumonectomy. In all cases the fistula was closed definitive. In one case developed a fistula between the pleural space and the oesophagus after operation.

Published
1975
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47. Über die Verteilung der benignen und malignen Pleuratumoren im Krankengut einer lungenchirurgischen Klinik mit besonderer Berücksichtigung des malignen Pleuramesothelioms und seiner radikalen Behandlung einschließlich der Ergebnisse des Zwerchfellersatzes mit konservierter Dura mater

Author

Maassen W and Bamler Kj

Subjects
Pulmonary and Respiratory Medicine, Radical treatment, medicine.medical_specialty, biology, business.industry, Dura mater, Pleura tumors, biology.organism_classification, Surgery, medicine.anatomical_structure, Diaphragma, Medicine, Lung surgery, Cardiology and Cardiovascular Medicine, business
Published
1974
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48. Towards zero energy hospital buildings: a polyclinic building as case study.

Author

Dainese Enrico, Walker Shalika, Maassen Wim, and Zeiler Wim

Subjects
Environmental sciences, GE1-350
Abstract

The need for (nearly) Zero Energy Buildings (nZEBs) becomes increasingly important due to climate change and increasing energy prices. Considering that, on average the existing hospitals use 3.5 times more energy than the nZEB requirement, reaching zero energy a very challenging task. However, monitoring hospitals’ energy flows together with a holistic view on building functions and occupancy can contribute to achieving potential energy savings, which is lacking in the current hospital buildings. Therefore, in this study, the energy saving potentials of a polyclinic building of a hospital in the Netherlands was investigated through a holistic inspection of the building and its occupancy. The analysis is performed in order to investigate the building characteristics, energy supply and demand. It was found that the number of people present was considerably lower than the full capacity, with 30% average occupancy in the medical facilities and 70% for the administrative areas. The air supply of the current ventilation system was found to be constant irrespective of the number of people present in these rooms. Furthermore, a discrepancy of 30- 50% was found between designed and installed lighting systems. The analysis of the polyclinic showed possible energy-saving measures with controlled ventilation rates and lighting according to the occupancy.

Published
2019
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49. Evaluation Dutch preliminary nZEB requirements for hospital and university buildings

Author

Maassen Wim

Subjects
Environmental sciences, GE1-350
Abstract

The need for (nearly) Zero Energy Buildings (nZEBs) in the Netherlands becomes increasingly important due to climate change, increasing energy prices, scarcity of fossil fuels and increasing geopolitical conflicts. In line with the EU EPBD, from 2020 new buildings, including hospital and university buildings, have to fulfil more strict energy requirements. Besides that, also the energy requirements for existing buildings will become stricter to realize an energy neutral built environment in 2050. On request of the Dutch Universities (WO) and the Dutch Academic Medical Centre’s (UMC), the Netherlands Enterprise Agency (RVO) assigned Royal HaskoningDHV to study the effect of the preliminary nZEB requirements on the real estate of the sector [1]. The feasibility of the nZEB requirements has been assessed for several representative, recently designed or realized buildings. For the selected hospital and university buildings, the results show that the preliminary nZEB requirements are not yet fulfilled. The requirement that 50% of building related energy should be of a local renewable energy source seems not to be feasible for both hospital and university buildings. Based on the results and recommendations of the study, a letter to the Dutch minister of the Ministry of the Interior and Kingdom Relations was sent and included a strong request to incorporate these in the definitive nZEB requirements, which will be set at the end of 2018.

Published
2019
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