Search

BackgroundCognitive behavioral therapy （CBT） is a widely used and empirically supported psychotherapy method. In recent years， the localization of CBT related to culture has received increasing attention from Chinese scholars. However， there is still a lack of systematic research on the localization of CBT using idioms as materials.ObjectiveTo explore whether idioms reflect the mutual influence between the two core therapeutic elements of CBT （cognition and emotion） and to use them as CBT treatment tools among college students， so as to provide references for the localization of CBT.MethodsUsing the Xinhua Idiom Dictionary （second edition） published by the Commercial Press， a three-round manual screening method was used to select idioms that reflected the mutual influence between cognition and emotion in CBT. Based on the selected idioms， a survey questionnaire titled "survey on idiom understanding level" was developed. From August to October， 2022， stratified sampling was conducted among college students from different majors and universities， and 815 valid questionnaires were obtained through the Questionnaire Star platform. By analyzing the understanding of each idiom among college students， idioms that could be used as CBT treatment tools were identified.ResultsIn the Xinhua Idiom Dictionary （second edition）， there were 13 idioms that reflected the influence of cognition on emotion and 5 idioms that reflected the influence of emotion on cognition. 12 idioms could be used as CBT treatment tools， including 8 idioms that reflected the influence of cognition on emotion and 4 idioms that reflected the influence of emotion on cognition.ConclusionThere may be idioms that reflect the mutual influence between the two core therapeutic elements of CBT （cognition and emotion） and these idioms can be attempted as a therapeutic tool for CBT among college students.

The neutron tube is the core component of the controllable neutron source logging instrument. Its working stability, temperature resistance, neutron yield and other indicators have an important impact on the working performance of instrument. At present, with the requirement of deep logging, the neutron tube used in logging is supposed to improve neutron yield, temperature resistance, operating life and working stability. In this paper, the structure, materials and manufacturing process of drive-in target neutron tube are designed and optimized to reduce power consumption and improve operating time. The temperature resistance, operating life, and neutron yield of sample tube have tested to estimate the performance of ENT2465 with an outer diameter of 25 millimeters. Place the sample tube in the oil tank of the neutron testing platform and connect the cable. Record the temperature, cumulative working time, neutron yield, target voltage, target current and anode current during the work of the sample tube. The results show that under the target voltage of 80 kV and target current less than 60 μA, the accumulated operating life of the sample tube exceeds 1 000 hours, including 23 hours of continuous operation at 175℃ and more than 500 hours of accumulated operation, and 36 hours of continuous operation at room temperature. The neutron yield only decreases by 5.3 % after 1 000 hours under the same target voltage and current.

Objective: To prepare antimicrobial peptides (AMPs) as a new alternative to antibiotics from walnut glutenin. Methods: AMPs were prepared by solid-state fermentation using Bacillus subtilis synchronized with alkaline protease treatment, separated, purified, and screened by successive ultrafiltration, gel filtration chromatography, liquid chromatography-tandem mass spectrometry (LC-MS/MS) and molecular docking. The stability of AMPs was studied by using Escherichia coli and Staphylococcus aureus as indicator strains. Results: fractions WGP-IIIA and WGP-IIIC, obtained after gel filtration chromatography, had strong antibacterial activity. By LC-MS/MS combined with virtual screening, 6 peptides were identified from the 2 fractions, and 3 peptides were obtained by molecular docking, namely LAEAYNIPDTIARRL from WGP-IIIA and SHSVIYVIR and APQLLYIVK from WGP-IIIC. The results of molecular docking showed that the antibacterial activity of WGP-IIIC was stronger. The AMPs were stable to high temperature, ultraviolet light, varying pH and different proteases. Conclusion: Walnut AMPs have application value in the field of food preservation.

Maintaining long-term stability of patient's condition is crucial in the treatment for bipolar disorder， while accurately assessing the patient's disease status is important and challenging in maintaining treatment. Excessive status expectation is common in patients with bipolar depression， which would warp the patient's perception of his or her own disease status and， thus， ultimately interfere with clinical decisions. Heightened vigilance should be given to such phenomenon. This paper explores the phenomenon and potential mechanisms of excessive status expectation in patients with bipolar disorder， providing ideas for related diagnosis， treatment and research. ［Funded by Jiangsu Provincial Science and Technology Project （number， BE2015609）］

The aim of the study was to investigate the diagnostic value of imaging necrosis (Imnecrosis) in grading, predict the genotype and prognosis of gliomas, and further assess tumor necrosis by dynamic contrast-enhanced MR perfusion imaging (DCE-MRI).

The ever-growing demand for miniaturized optical systems presents a significant challenge in revolutionizing their core element – the varifocal lens. Recent advancements in ultra-thin, tunable metasurface optics have introduced new approaches to achieving zoom imaging. However, current varifocal metalens have faced challenges such as low focusing efficiency, limited tunability, and complicated designs. Here, we employ the high-contrast transmit arrays (HCTA) structures to design and fabricate a polarization-independent, single-layer flexible metalens that operates at a wavelength of 940 nm. Using a uniform stretching system, we characterized its optical performance to achieve over 60 % focusing efficiency within a 0 %–25 % stretch range, while the focal length changes align with theoretical predictions. Furthermore, our research also successfully demonstrated the capacity of a metalens with a numerical aperture (NA) of 0.5 to efficiently adjust imaging magnification within a 2× range, achieving imaging results that approach the diffraction limit. This research offers promising prospects for the practical use of compact and miniaturized optoelectronic devices in fields like photography, mixed reality, microscopy, and biomedical imaging.

High beam quality, large-area output, and small footprint are significant pursuing goals for vertical-cavity surface-emitting lasers (VCSELs), which impose strict requirements on tight light confinements with minimized radiation losses. To achieve this, bound states in the continuum (BICs) have been demonstrated as an effective way of trapping light. Here, we combine BICs and photonic bandgaps to realize a quasi-BIC single-mode photonic crystal (PhC) laser on a colloidal quantum dots (CQDs)/silicon oxide (SiO2) hybrid integrated platform. The PhC cavity is a defect-free hexagonal heterostructure with three regions, and the thin CQDs film is embedded within the SiO2 nanopillar planar array as both an optical gain material and a backbone for the PhC. The mode gaps between different regions provide the lateral confinement while the quasi-BICs near the Γ-point generate the small-divergence vertical radiation coupling, resulting in a well-defined emission concentrating within ±1.85° of the normal surface direction and an optical pumping energy density threshold of 216.75 μJ/cm2. Our results demonstrate the design flexibility and versatility of the quasi-BIC laser even with a low contrast of a refractive index between the PhC slab and the substrate, which has potential applications in cavity quantum electrodynamics, nonlinear optics, and integrated photonics.

Objective To investigate the relationship between the expression of CXC chemokine ligand 8 (CXCL8) and miR-150 in the skin lesions of patients with psoriasis vulgaris and the severity of the disease. Methods The skin lesions of 80 patients with psoriasis vulgaris who were treated in Nanyang first people's Hospital from January 2020 to May 2021 were selected as the research objects. The normal tissues around the skin lesion were chosen as a control. The Psoriasis Area and Severity Index (PASI) was used to classify patients with psoriasis, the immunohistochemical method was used to detect the expression of CXCL8 protein, the real time fluorescence quantitative PCR method was used to detect the expression of miR-150, Western blot was used to detect the expression of CXCL8 protein, and the correlation between the expression levels of CXCL8 protein, miR-150 and the severity of the disease was further analyzed. Results The level of CXCL8 mRNA in the skin lesion of patients with psoriasis vulgaris was higher than that in normal tissues (P＜0.05) and the level of miR-150 was lower than that in normal tissues(P＜0.05). The expression of CXCL8 protein in the skin lesions of patients was 68.75%, which was significantly higher than 37.50% in normal tissues (P＜0.05); the expression of CXCL8 protein in the skin lesions of patients was significantly higher than that in normal tissues (P＜0.05); the level of miR-150 gradually decreased with the aggravation of the disease (P＜0.05), and the level of CXCL8 protein gradually increased with the aggravation of the disease (P＜0.05); Pearson results showed that there was a negative correlation between miR-150 level in patients with psoriasis vulgaris and CXCL8 protein level and PASI score (r=-0.467, -0.475, P＜0.05), and there was a positive correlation between CXCL8 protein level and PASI score (r=0.424, P＜0.05). Conclusions The expression of miR-150 decreased and CXCL8 increased in patients with psoriasis vulgaris, both of them were related to the severity of the disease.

Glioblastoma (GBM) is a malignant brain tumor. The purpose of this study is to estimate the potential effects and underlying mechanisms of a ubiquitin-specific protease 8 (USP8) small-molecule inhibitor on the phenotypic characteristics of GBM cells. The growth, migration, invasion, and stemness of GBM LN229 and T98G cells were evaluated by conducting cell proliferation, colony formation, wound healing, transwell, Ki-67 staining, spheroid formation, and ionizing radiation assays, and the results collectively showed the suppressive effects of USP8 inhibition on GBM cells. Furthermore, transcriptomic profiling of GBM cells treated with the USP8 inhibitor deubiquitinase (DUB)-IN-1 revealed significantly altered mRNA expression induced by pharmacological USP8 inhibition, from which we confirmed downregulated Aurora kinase A (AURKA) protein levels using immunoblotting assays. Our findings indicated that the proliferation, invasion, and stemness of LN229 and T98G cells were markedly suppressed by USP8 inhibition. Pharmacological USP8 suppression elicits multiple tumor-inhibitory effects, likely through dysregulating various mRNA expression events, including that of the key cell cycle regulator and oncogenic protein AURKA. Therefore, our observations corroborate the GBM-supportive roles of USP8 and suggest pharmacological USP8 inhibition is a viable therapeutic approach to target GBM. The purpose of this study was to investigate the effect and mechanism of action of the USP8 inhibitor DUB-IN-1 on GBM.

Objective To explore the method of measuring root volume with cone-beam computed tomography (CBCT) three-dimensional reconstruction technology, and to study root length and root volume of upper and lower central incisors in patients with skeletal Class Ⅲ malocclusion treated by surgical orthodontic treatment. Methods Twenty patients with skeletal Class Ⅲ malocclusion undergoing surgical orthodontic treatment were selected. CBCT data at three time points, before decompensation treatment (T0), after decompensation treatment (before orthognathic surgery, T1), and the end of post-operative orthodontic treatment (T2) were collected. Three-dimensional reconstruction technology was used to measure the root length and root volume of the upper and lower central incisors (including total root volume, cervical root and apical root), calculate the percentage of reduction volume, and measure the distance of tooth movement after orthodontic treatment. Data were statistically analyzed by SPSS 20.0 software. Least significant difference (LSD) method was used for pair comparison between the groups subject to normal distribution, and non-parametric test was used for comparison between the groups not subject to normal distribution. The differences of root length and root volume of upper and lower incisors were compared, and the characteristics of root absorption were analyzed. Results Root length and root volume of the upper and lower central incisors were reduced during the surgical orthodontic treatment (P < 0.05) in cases. Both the root volume of cervical root and apical root were significantly reduced (P < 0.05), the reduction of apical root was more significant. The percentage of root volume reduction of the upper central incisor was (30.51±23.23)%, and lower central incisor (23.24±11.96)%. Compared with the upper central incisor, the root volume reduction amount and percentage of the lower central incisor were smaller, and apical root volume reduction of the upper central incisor was greater than that of the lower central incisor, which was statistically significant (P < 0.05). During pre-surgical orthodontic treatment, maxillary central incisor palatal moving was in a controlled tipping manner, and the mandibular central incisor tipped labially. Conclusion In patients with skeletal Class Ⅲ malocclusion, root length and total root volume of upper and lower central incisors decreased during surgical orthodontic treatment. Root volume measurement indicated that the cervical root also had root resorption. The difference in root resorption of the upper and lower central incisors might be related to the distance and direction of teeth movement. CBCT three-dimensional reconstruction will compensate for the limitation of root length measurement in evaluating root resorption.

Full-space metasurfaces demonstrate powerful abilities in manipulating electromagnetic (EM) waves, but most of them are usually single band. Here, a multiband bidirectional digital coding metasurface is proposed for multiple tasks, which can achieve completely different functions in up to six frequency bands when the EM waves are incident from the front and back of the metasurface. As a proof-of-concept, we design and fabricate a dual-band full-space metasurface with integrated functions of reflection, transmission, holographic imaging, and vortex-beam forming, and a six-band full-space metasurface with completely independent holographic imaging functions at different frequency bands. Simulated and measured results are in good agreements with the theoretical predictions, verifying the good performance of the proposed multitask bidirectional digital coding metasurface.

Ultrasensitive trace-detection of toxic and carcinogenic polycyclic aromatic hydrocarbons (PAHs) can ceaselessly propel the environmental surveillance in aqueous ecosystems. Due to the intrinsic nonadsorptive feature of PAHs, the promising technique of surface-enhanced Raman scattering (SERS) spectroscopy has been restricted to diverse functional ligands-based surface modifications of nano-substrates. However, it is not suitable for practical ultralow liquid analysis. Herein, we propose an extraordinary strategy to boost liquid-near infrared (NIR)-SERS activity of plasmonic Au/Ag nano-urchins (NUs) by introducing extra 808 nm laser-triggered an additional strong electromagnetic enhancement into routine 785 nm laser-Raman system. The synergistic double laser-excited NIR-SERS of colloidal Au/Ag NUs enables the Raman signals of crystal violet to be significantly enhanced, approaching a maximum of ∼34-fold increase than that of traditional bare 785 nm laser-excitation. More importantly, the improved liquid-NIR-SERS enables the in-situ detection limit of pyrene molecules in lake water to be achieved at ∼10−9 M, which is already better than many previous SERS results based on the complicated functionalized nano-substrates. The established double laser-boosted NIR-SERS can also be easily extended to the simultaneous trace-detection of three PAHs-contaminated mixtures, supporting well distinguishable capability. Undoubtedly, the present work opens a new versatile and innovative avenue for ultrasensitive NIR-SERS monitoring of nonadsorptive toxic pollutants in wastewater.

Objective: Established a group of models used to quickly distinguish anti-counterfeit cigarette packaging paper. Methods: The model based on the same color oil on packaging paper from 3 different brands: Yunyan, Yuxi, and Hongtashan. The Fourier Transform infrared spectroscopy （FTIR） spectrum were collected from 116 samples totally by Attenuated Total Reflection （ATR） accessary. 56 spectrum were used to build the models and 20 samples of each brand were used to verification. Spectrum were second derivative processed and spectral ranges were selected as 3 200~2 700, 1 800~1 580, and 801~720 cm-1. Results: Using Mahalanobis distance discriminant method to establish 4 models （3 brands and 1 multiple）, all of the accuracy of models reached to 100%. Conclusion: This is the first time to use the same color oil FTIR spectrum to distinguish real and fake cigarette packaging paper which were highly improve selection efficiency for large number of samples.

Recent studies indicate that host immune responses are dysregulated with either myeloid cell compartment or lymphocyte composition being disturbed in COVID-19. This study aimed to assess the impact of SARS-CoV-2 viral infection on the composition of circulating immune cells in severe COVID-19 patients. In this retrospective single-center cohort, 71 out of 87 COVID-19 patients admitted to the intense care unit for oxygen treatment were included in this study. Demographics, clinical features, comorbidities, and laboratory findings were collected on admission. Out of the 71 patients, 5 died from COVID-19. Compared with survived patients, deceased patients showed higher blood cell counts of neutrophils and monocytes but lower cell counts of lymphocytes. Intriguingly, the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and basophil-to-lymphocyte ratio (BLR) were markedly higher in deceased patients compared to survived patients. Furthermore, the lymphocyte counts were negatively correlated with D-dimer levels, while the ratios between myeloid cells and lymphocyte (NLR, MLR, and BLR) were positively correlated with D-dimer levels. Our findings revealed that the ratios between myeloid cells and lymphocytes were highly correlated with coagulation status and patient mortality in severe COVID-19.

Tibetan monks have a special way of life and food habits, however, little is known about their dyslipidemia. This study aimed to investigate the prevalence of dyslipidemia and risk factors of this population. A cross-sectional study of dyslipidemia was conducted in 876 Tibetan monks and 912 local residents in the same area. All subjects underwent interviews and physical examinations. The total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) of the subjects were analyzed. Compared to local residents, the overall prevalence of dyslipidemia in monks was 29.5%, which was significantly lower (p

BACKGROUND By measuring the nitrogen content in plant fruits, the growth status of plants can be grasped and important information for improving the yield of high-quality fruits can be provided. At present, the traditional Kjeldahl method is used to determine nitrogen in plant fruits. The main steps are digestion, distillation and titration. The digestion time of traditional method is 90 minutes, and the titration and distillation time is 10-20 minutes. The determination process is complicated and produces errors, which is not suitable for the analysis of large amounts of plant fruits. OBJECTIVES To shorten the analysis and determination time of total nitrogen in plant fruit samples, improve work efficiency, avoid artificial errors, and solve the problems of sample splashing and white smoke escaping during digestion. METHODS A graphite digestion instrument was used for digestion. Concentrated sulfuric acid and a catalyst were added, the reflux plug was capped, and an automatic nitrogen determination instrument was used for analysis. RESULTS The sample did not splash and the white smoke did not escape. The digestion time was 50 minutes and the distillation time was 3 minutes. The reagent consumption was reduced by 2mL. The relative error and relative standard deviation were less than 5%. CONCLUSIONS The established method meets the needs of the laboratory to quickly and accurately detect total nitrogen in large amounts of plant samples. It has been applied in the detailed survey project of the China geological survey bidding project and the detailed investigation of the soil pollution status of agricultural land in Hebei Province.

Aiming to slove the PI controller′s problem that it is difficult to achieve the fast and accuracy performances of Vienna rectifier， this paper proposed a novel composited nonlinear control strategy with sliding mode controller(SMC) and Quasi proportional resonant(QPR) controller, which can enhance the accuracy performance and the sinusoidal degree of the three-phase currents. In addition, the rapidity and robust performance of DC voltage have also been improved when starting up the rectifier or the load is disturbed. Finally, the MATLAB/Simulink model and experimental platform based on Vienna-type rectifier were built, the results show that the composited control strategy not only has the adventages of the sliding mode control strategy, but also has better robust and dynamic performance. Meanwhile the speed and accuracy of the system have also been greatly improved.

Based on the problem of corrosion acceleration possibly existing in aluminum alloy sheets under the influence of both loading and brine solution, the corrosion behavior of 5A06 aluminum alloy sheets with the thickness of 1.8mm by the two-point bending method in 3.5% NaCl aqueous solution at 50℃ was discussed.It is found that stress actually can promote the speed of corrosion in these aluminum alloy sheets.Crack morphologies, metallurgical structures and elemental compositions in different corrosion periods of these samples were analyzed.The results show:firstly, large stress will cause severe corrosion, which proves that stress can accelerate the corrosion; secondly, the solid solution strengthening phase in aluminum alloy can cause the anode areas preferentially dissolve, resulting in the formation of corrosion pits.Furthermore, stress can result in tearing of oxide film on the aluminum alloy surface, and facilitate corrosion crack propagation.

A new type of environmental-friendly flexible nanofibers of aluminum doped zinc oxide (AZO) coated carbon (AZO@C) was successfully prepared by using polyvinyl alcohol (PVA) as raw materials. The as-spun PVA nanofibers were prepared via electrospinning and its water resistance was greatly improved after heat-treatment. Then, the PVA nanofibers with a layer of zinc aluminum hydroxide on the surface were synthesized by hydrothermal method. Thereafter, new AZO@C composite nanofibers was produced after sintering at 500℃ to the carbonization of PVA nanofibers and the dehydration of zinc aluminum hydroxide to form AZO nanoparticles. The structure and properties of the samples were characterized by Fourier-transform infrared spectrometer (FT-IR), thermal gravimetric analyzer (TGA) and scanning electron microscope (SEM). The average diameter of the AZO@C nanofibers is (320±45)nm. The photocatalytic property of the resultant composite fibers is demonstrated by degrading methyl orange under solar light.